IARS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of isoleucine-tRNA synthetase exist, a cytoplasmic form and a mitochondrial form. This gene encodes the mitochondrial isoleucine-tRNA synthetase which belongs to the class-I aminoacyl-tRNA synthetase family. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.56449654
2nuclear pore organization (GO:0006999)5.96263625
3Golgi transport vesicle coating (GO:0048200)5.88703018
4COPI coating of Golgi vesicle (GO:0048205)5.88703018
5lysine catabolic process (GO:0006554)5.74143737
6lysine metabolic process (GO:0006553)5.74143737
7DNA unwinding involved in DNA replication (GO:0006268)4.89984758
8valine metabolic process (GO:0006573)4.80511413
9fatty acid transmembrane transport (GO:1902001)4.76587940
10carnitine shuttle (GO:0006853)4.75910413
11pore complex assembly (GO:0046931)4.69735921
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.69666521
13L-phenylalanine catabolic process (GO:0006559)4.69666521
14alpha-linolenic acid metabolic process (GO:0036109)4.68780192
15fatty acid beta-oxidation (GO:0006635)4.60729102
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.59465523
17L-phenylalanine metabolic process (GO:0006558)4.59465523
182-oxoglutarate metabolic process (GO:0006103)4.55576684
19mitotic chromosome condensation (GO:0007076)4.54790833
20aspartate family amino acid catabolic process (GO:0009068)4.40660990
21acetyl-CoA metabolic process (GO:0006084)4.38817102
22fatty acid oxidation (GO:0019395)4.30698224
23cysteine metabolic process (GO:0006534)4.29436549
24lipid oxidation (GO:0034440)4.21287271
25regulation of sequestering of triglyceride (GO:0010889)4.19690800
26short-chain fatty acid metabolic process (GO:0046459)4.19344755
27tricarboxylic acid metabolic process (GO:0072350)4.18340665
28positive regulation of fatty acid beta-oxidation (GO:0032000)4.17085669
29proline biosynthetic process (GO:0006561)4.09277249
30low-density lipoprotein particle clearance (GO:0034383)4.09215252
31amino-acid betaine metabolic process (GO:0006577)4.08937617
32triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.03769426
33fatty acid catabolic process (GO:0009062)4.01777405
34tricarboxylic acid cycle (GO:0006099)4.01535423
35regulation of fatty acid oxidation (GO:0046320)3.92993533
36sulfur amino acid catabolic process (GO:0000098)3.92745963
37regulation of fatty acid beta-oxidation (GO:0031998)3.91766546
38formation of translation preinitiation complex (GO:0001731)3.90684022
39glyoxylate metabolic process (GO:0046487)3.87354481
40carnitine metabolic process (GO:0009437)3.87286409
41ethanol oxidation (GO:0006069)3.83191506
42fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.82317184
43positive regulation of fatty acid oxidation (GO:0046321)3.79942623
44regulation of triglyceride catabolic process (GO:0010896)3.75426671
45branched-chain amino acid catabolic process (GO:0009083)3.73716919
46branched-chain amino acid metabolic process (GO:0009081)3.73589742
47carnitine transmembrane transport (GO:1902603)3.72365774
48biotin metabolic process (GO:0006768)3.70774274
49aromatic amino acid family catabolic process (GO:0009074)3.70768175
50maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.70587542
51ribosome assembly (GO:0042255)3.70299524
52* regulation of translational fidelity (GO:0006450)3.70084042
53regulation of cholesterol homeostasis (GO:2000188)3.68909364
54phospholipid homeostasis (GO:0055091)3.68571752
55carnitine transport (GO:0015879)3.68091837
56amino-acid betaine transport (GO:0015838)3.68091837
57monocarboxylic acid catabolic process (GO:0072329)3.66254288
58desmosome organization (GO:0002934)3.66143791
59plasma lipoprotein particle clearance (GO:0034381)3.65053272
60homocysteine metabolic process (GO:0050667)3.63915744
61regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.63622300
62kynurenine metabolic process (GO:0070189)3.62190223
63fatty acid homeostasis (GO:0055089)3.57758518
64negative regulation of fatty acid biosynthetic process (GO:0045717)3.57607203
65cellular ketone body metabolic process (GO:0046950)3.55163842
66protein retention in ER lumen (GO:0006621)3.54721080
67regulation of mitotic spindle organization (GO:0060236)3.53827371
68protein complex localization (GO:0031503)3.53474247
69acyl-CoA biosynthetic process (GO:0071616)3.52819753
70thioester biosynthetic process (GO:0035384)3.52819753
71retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.51498217
72mitotic sister chromatid cohesion (GO:0007064)3.50600356
73oxaloacetate metabolic process (GO:0006107)3.49352020
74mitotic sister chromatid segregation (GO:0000070)3.49006715
75dicarboxylic acid biosynthetic process (GO:0043650)3.47665878
76nucleobase-containing small molecule interconversion (GO:0015949)3.45214738
77cellular protein complex localization (GO:0034629)3.44147007
78bile acid biosynthetic process (GO:0006699)3.42060982
79complement activation, alternative pathway (GO:0006957)3.41385501
80sister chromatid segregation (GO:0000819)3.40262996
81protein localization to chromosome, centromeric region (GO:0071459)3.37798070
82succinate metabolic process (GO:0006105)3.34735542
83COPII vesicle coating (GO:0048208)3.34119759
84mitotic nuclear envelope disassembly (GO:0007077)3.33647598
85DNA strand elongation involved in DNA replication (GO:0006271)3.32289844
86serine family amino acid catabolic process (GO:0009071)3.30535809
87alpha-amino acid catabolic process (GO:1901606)3.30354424
88triglyceride catabolic process (GO:0019433)3.29921869
89protein carboxylation (GO:0018214)3.29003920
90peptidyl-glutamic acid carboxylation (GO:0017187)3.29003920
91establishment of integrated proviral latency (GO:0075713)3.28271238
92urea cycle (GO:0000050)3.28246002
93urea metabolic process (GO:0019627)3.28246002
94triglyceride homeostasis (GO:0070328)3.27748989
95acylglycerol homeostasis (GO:0055090)3.27748989
96cellular modified amino acid catabolic process (GO:0042219)3.27208877
97regulation of protein activation cascade (GO:2000257)3.27048437
98positive regulation of lipid catabolic process (GO:0050996)3.27015427
99ketone body metabolic process (GO:1902224)3.26398929
100mitotic metaphase plate congression (GO:0007080)3.25785441
101ethanol metabolic process (GO:0006067)3.24869719
1024-hydroxyproline metabolic process (GO:0019471)3.23450080
103DNA strand elongation (GO:0022616)3.23007157
104regulation of RNA export from nucleus (GO:0046831)3.19269253
105cellular amino acid catabolic process (GO:0009063)3.18857913
106regulation of cholesterol metabolic process (GO:0090181)3.18368482
107quaternary ammonium group transport (GO:0015697)3.17302635
108acylglycerol catabolic process (GO:0046464)3.17143966
109neutral lipid catabolic process (GO:0046461)3.17143966
110regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.16623467
111carboxylic acid catabolic process (GO:0046395)3.15606806
112organic acid catabolic process (GO:0016054)3.15606806
113negative regulation of fibrinolysis (GO:0051918)3.15428391
114glycine metabolic process (GO:0006544)3.15226579
115regulation of complement activation (GO:0030449)3.14877115
116glutamate metabolic process (GO:0006536)3.14461172
117high-density lipoprotein particle remodeling (GO:0034375)3.13985478
118nuclear envelope disassembly (GO:0051081)3.13518621
119membrane disassembly (GO:0030397)3.13518621
120negative regulation of fatty acid metabolic process (GO:0045922)3.11603746
121regulation of cholesterol storage (GO:0010885)3.10656317
122acyl-CoA metabolic process (GO:0006637)3.10579683
123thioester metabolic process (GO:0035383)3.10579683
124NADH metabolic process (GO:0006734)3.09970854
125folic acid-containing compound biosynthetic process (GO:0009396)3.09103956
126fatty-acyl-CoA biosynthetic process (GO:0046949)3.08600601
127hemidesmosome assembly (GO:0031581)3.05849813
128positive regulation of triglyceride metabolic process (GO:0090208)3.05306723
129intracellular lipid transport (GO:0032365)3.02036213
130serine family amino acid metabolic process (GO:0009069)3.00816781
131protein localization to kinetochore (GO:0034501)2.99818363
132nitrogen cycle metabolic process (GO:0071941)2.99107565
133bile acid metabolic process (GO:0008206)2.98168326
134vesicle coating (GO:0006901)2.98133465
135reverse cholesterol transport (GO:0043691)2.96898574
136tyrosine metabolic process (GO:0006570)2.96236261
137epoxygenase P450 pathway (GO:0019373)2.93673840
138DNA duplex unwinding (GO:0032508)2.90480760
139DNA replication initiation (GO:0006270)2.89325398
140regulation of translational termination (GO:0006449)2.89114015
141chromosome condensation (GO:0030261)2.86608315
142bundle of His cell to Purkinje myocyte communication (GO:0086069)2.85399610
143telomere maintenance via semi-conservative replication (GO:0032201)2.82132336
144regulation of sister chromatid cohesion (GO:0007063)2.81228556
145regulation of nucleobase-containing compound transport (GO:0032239)2.80884553
146protein export from nucleus (GO:0006611)2.80265591
147regulation of spindle organization (GO:0090224)2.79230702
148pentose-phosphate shunt (GO:0006098)2.78890055
149spliceosomal tri-snRNP complex assembly (GO:0000244)2.77559865
150nuclear envelope organization (GO:0006998)2.76203974
151DNA geometric change (GO:0032392)2.73466269
152metaphase plate congression (GO:0051310)2.72947549
153proline metabolic process (GO:0006560)2.70921452
154folic acid metabolic process (GO:0046655)2.70793412
155IMP metabolic process (GO:0046040)2.68455195
156paraxial mesoderm development (GO:0048339)2.68229826
157* tRNA aminoacylation for protein translation (GO:0006418)2.68101457
158NADPH regeneration (GO:0006740)2.67299865
159protein maturation by protein folding (GO:0022417)2.66732755
160protein hydroxylation (GO:0018126)2.62232170
161L-serine metabolic process (GO:0006563)2.58025285
162positive regulation of chromosome segregation (GO:0051984)2.56611740
163* tRNA aminoacylation (GO:0043039)2.56182076
164* amino acid activation (GO:0043038)2.56182076
165double-strand break repair via nonhomologous end joining (GO:0006303)2.55593241
166non-recombinational repair (GO:0000726)2.55593241
167DNA topological change (GO:0006265)2.54921004
168peptidyl-proline hydroxylation (GO:0019511)2.53781135
169protein localization to microtubule (GO:0035372)2.52539000
170IMP biosynthetic process (GO:0006188)2.51344217
171DNA conformation change (GO:0071103)2.50768515
172glutamine family amino acid biosynthetic process (GO:0009084)2.48648784
173establishment of chromosome localization (GO:0051303)2.47872761
174DNA packaging (GO:0006323)2.43489246
175heterochromatin organization (GO:0070828)2.42836441
176epithelial cell-cell adhesion (GO:0090136)2.41849239
177regulation of mammary gland epithelial cell proliferation (GO:0033599)2.41604203
178maternal placenta development (GO:0001893)2.40943466
179cell-substrate junction assembly (GO:0007044)2.40491885
180glycolytic process (GO:0006096)2.39894640
181cell adhesion mediated by integrin (GO:0033627)2.39107426
182tetrahydrofolate metabolic process (GO:0046653)2.38083428
183regulation of chromosome segregation (GO:0051983)2.36735983
184adherens junction assembly (GO:0034333)2.36222910
185glutamine metabolic process (GO:0006541)2.35684715
186glucose catabolic process (GO:0006007)2.35501602
187positive regulation of cell cycle checkpoint (GO:1901978)2.35278979
188negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.34886633
189positive regulation of nuclease activity (GO:0032075)2.33473736
190cell-substrate adherens junction assembly (GO:0007045)2.32987720
191focal adhesion assembly (GO:0048041)2.32987720
192activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.31049426
193telomere maintenance via recombination (GO:0000722)2.28986026
194mitotic recombination (GO:0006312)2.28971435

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.25173681
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.17719622
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.06970467
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.71781274
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.20366042
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.80235609
7TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.74575305
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.54407816
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.33192723
10CLOCK_20551151_ChIP-Seq_293T_Human3.20942683
11TP63_17297297_ChIP-ChIP_HaCaT_Human3.06044189
12FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.98864992
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.78739904
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.78497192
15EGR1_23403033_ChIP-Seq_LIVER_Mouse2.76236586
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.70041864
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.54898770
18ZNF263_19887448_ChIP-Seq_K562_Human2.52005393
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.39750519
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.36796390
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.32998292
22GATA1_22025678_ChIP-Seq_K562_Human2.31580314
23* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.25141057
24CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.23128870
25* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.22440768
26* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.14360630
27MYC_18358816_ChIP-ChIP_MESCs_Mouse2.14278002
28PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.11967432
29MYCN_18555785_ChIP-Seq_MESCs_Mouse1.95622249
30XRN2_22483619_ChIP-Seq_HELA_Human1.79908954
31E2F1_21310950_ChIP-Seq_MCF-7_Human1.79495494
32HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.77484934
33RARG_19884340_ChIP-ChIP_MEFs_Mouse1.76032776
34DCP1A_22483619_ChIP-Seq_HELA_Human1.72895509
35CREB1_15753290_ChIP-ChIP_HEK293T_Human1.72732681
36STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.70230080
37FOXO3_23340844_ChIP-Seq_DLD1_Human1.67165573
38KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.66769458
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64798315
40DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.63470001
41* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.62582028
42CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.61353473
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55901638
44SOX2_27498859_Chip-Seq_STOMACH_Mouse1.54282555
45STAT3_1855785_ChIP-Seq_MESCs_Mouse1.53883564
46ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.53426887
47CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.53377889
48KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.52715645
49TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.52222950
50THAP11_20581084_ChIP-Seq_MESCs_Mouse1.51857383
51FOXA2_19822575_ChIP-Seq_HepG2_Human1.48430988
52TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.48015621
53HIF1A_21447827_ChIP-Seq_MCF-7_Human1.47236556
54PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.43108381
55TBX20_22328084_ChIP-Seq_HEART_Mouse1.42646742
56TBX20_22080862_ChIP-Seq_HEART_Mouse1.42646742
57HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.39924670
58CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.37896831
59JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.36468657
60ATF3_27146783_Chip-Seq_COLON_Human1.35969493
61ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.35390644
62PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.34517130
63CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.34246975
64CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.33848538
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33091577
66TFEB_21752829_ChIP-Seq_HELA_Human1.32966623
67YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32651616
68TTF2_22483619_ChIP-Seq_HELA_Human1.31782167
69AR_21909140_ChIP-Seq_LNCAP_Human1.30105603
70ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.29955275
71EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.29888628
72ESR2_21235772_ChIP-Seq_MCF-7_Human1.29519315
73NANOG_18555785_ChIP-Seq_MESCs_Mouse1.29449100
74ESR1_15608294_ChIP-ChIP_MCF-7_Human1.29285291
75ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.29017758
76* GATA6_25053715_ChIP-Seq_YYC3_Human1.28166739
77SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.27386232
78RACK7_27058665_Chip-Seq_MCF-7_Human1.27288465
79SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.26815072
80CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.26570032
81ESR1_20079471_ChIP-ChIP_T-47D_Human1.25630314
82PPAR_26484153_Chip-Seq_NCI-H1993_Human1.23568213
83* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.21139973
84STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.20598556
85SOX17_20123909_ChIP-Seq_XEN_Mouse1.19835486
86* KDM5A_27292631_Chip-Seq_BREAST_Human1.18523627
87KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18442128
88* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.17753256
89ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.17368851
90EGR1_19374776_ChIP-ChIP_THP-1_Human1.16098782
91* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.15356902
92GABP_19822575_ChIP-Seq_HepG2_Human1.14451815
93* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14170480
94MYC_22102868_ChIP-Seq_BL_Human1.14045891
95MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.12793239
96GATA4_25053715_ChIP-Seq_YYC3_Human1.11997797
97KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.11743464
98HNF4A_19822575_ChIP-Seq_HepG2_Human1.10982193
99PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09751040
100ESR1_21235772_ChIP-Seq_MCF-7_Human1.09649778
101ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08691785
102* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.07821346
103FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.07681876
104NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.07611720
105TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.07160051
106ETS1_20019798_ChIP-Seq_JURKAT_Human1.07057385
107NANOG_21062744_ChIP-ChIP_HESCs_Human1.06576236
108TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05913784
109SALL4_18804426_ChIP-ChIP_XEN_Mouse1.03973503
110* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.03765815
111GATA1_19941826_ChIP-Seq_K562_Human1.02808865
112POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.02751837
113FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.02706132
114NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.02662695
115RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01763703
116* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01343284
117FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.99514162
118ELK3_25401928_ChIP-Seq_HUVEC_Human0.99117826
119GATA4_21415370_ChIP-Seq_HL-1_Mouse0.98793336
120TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97927500
121KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.97023541
122SOX9_24532713_ChIP-Seq_HFSC_Mouse0.96557265
123TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.96060806
124* CHD1_26751641_Chip-Seq_LNCaP_Human0.96049093
125TBX5_21415370_ChIP-Seq_HL-1_Mouse0.95916273
126E2F7_22180533_ChIP-Seq_HELA_Human0.95839247
127ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.95623391
128UBF1/2_26484160_Chip-Seq_HMECs_Human0.94510801
129BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94005500
130KDM2B_26808549_Chip-Seq_DND41_Human0.93656547
131AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.93595539
132KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.90231917
133* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.88681170
134NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.88347512
135* TCF7_22412390_ChIP-Seq_EML_Mouse0.87320001
136NCOR1_26117541_ChIP-Seq_K562_Human0.86988010
137EP300_21415370_ChIP-Seq_HL-1_Mouse0.86827371
138TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.86073943
139CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.84509211
140LXR_22292898_ChIP-Seq_THP-1_Human0.83058149
141GATA3_24758297_ChIP-Seq_MCF-7_Human0.82942415
142RUNX1_27514584_Chip-Seq_MCF-7_Human0.82577642
143GATA2_19941826_ChIP-Seq_K562_Human0.82195444
144P63_26484246_Chip-Seq_KERATINOCYTES_Human0.81008204
145CDX2_20551321_ChIP-Seq_CACO-2_Human0.80300523
146TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.78969321
147SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.78545040
148SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.78545040
149* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.77238704
150MYB_21317192_ChIP-Seq_ERMYB_Mouse0.76336021
151TRIM28_21343339_ChIP-Seq_HEK293_Human0.76328049
152VDR_21846776_ChIP-Seq_THP-1_Human0.75982064
153GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.75014304
154* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.73571640
155KLF4_18555785_ChIP-Seq_MESCs_Mouse0.73234625
156TCF3_18692474_ChIP-Seq_MEFs_Mouse0.72518280
157THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.71327898

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.77597593
2MP0002139_abnormal_hepatobiliary_system4.59507993
3MP0005085_abnormal_gallbladder_physiolo3.65302881
4MP0005365_abnormal_bile_salt3.44846462
5MP0003806_abnormal_nucleotide_metabolis3.36730202
6MP0003705_abnormal_hypodermis_morpholog3.20736999
7MP0002837_dystrophic_cardiac_calcinosis2.68166920
8MP0004130_abnormal_muscle_cell2.66126402
9MP0003941_abnormal_skin_development2.64122502
10MP0004957_abnormal_blastocyst_morpholog2.61668062
11MP0005670_abnormal_white_adipose2.61315331
12MP0003111_abnormal_nucleus_morphology2.55719529
13MP0003252_abnormal_bile_duct2.53775671
14MP0010094_abnormal_chromosome_stability2.52913369
15MP0010329_abnormal_lipoprotein_level2.52743077
16MP0008875_abnormal_xenobiotic_pharmacok2.48591910
17MP0005666_abnormal_adipose_tissue2.46696395
18MP0003693_abnormal_embryo_hatching2.43643267
19MP0009840_abnormal_foam_cell2.33040276
20MP0004185_abnormal_adipocyte_glucose2.29535382
21MP0004084_abnormal_cardiac_muscle2.12561112
22MP0005083_abnormal_biliary_tract2.09815372
23MP0003077_abnormal_cell_cycle2.08106766
24MP0003191_abnormal_cellular_cholesterol2.01410721
25MP0005332_abnormal_amino_acid1.99819844
26MP0010234_abnormal_vibrissa_follicle1.94764192
27MP0001730_embryonic_growth_arrest1.92255454
28MP0002009_preneoplasia1.92122365
29MP0008932_abnormal_embryonic_tissue1.91504897
30MP0005330_cardiomyopathy1.85650224
31MP0001666_abnormal_nutrient_absorption1.79854387
32MP0000609_abnormal_liver_physiology1.75010337
33MP0005375_adipose_tissue_phenotype1.73609249
34MP0002118_abnormal_lipid_homeostasis1.73607334
35MP0005076_abnormal_cell_differentiation1.69999245
36MP0003195_calcinosis1.69104576
37MP0010352_gastrointestinal_tract_polyps1.67780522
38MP0008057_abnormal_DNA_replication1.65958877
39MP0004036_abnormal_muscle_relaxation1.61989062
40MP0003566_abnormal_cell_adhesion1.56593524
41MP0004087_abnormal_muscle_fiber1.55247131
42MP0003300_gastrointestinal_ulcer1.55057251
43MP0000350_abnormal_cell_proliferation1.54086020
44MP0009697_abnormal_copulation1.51818208
45MP0002971_abnormal_brown_adipose1.48882492
46MP0005380_embryogenesis_phenotype1.46424134
47MP0001672_abnormal_embryogenesis/_devel1.46424134
48MP0008007_abnormal_cellular_replicative1.44635640
49MP0004215_abnormal_myocardial_fiber1.43647034
50MP0005319_abnormal_enzyme/_coenzyme1.43186428
51MP0010630_abnormal_cardiac_muscle1.43178018
52MP0003984_embryonic_growth_retardation1.42468463
53MP0002269_muscular_atrophy1.41342735
54MP0001849_ear_inflammation1.40371945
55MP0000751_myopathy1.38361770
56MP0008438_abnormal_cutaneous_collagen1.37934844
57MP0002088_abnormal_embryonic_growth/wei1.36228583
58MP0004782_abnormal_surfactant_physiolog1.34032270
59MP0002080_prenatal_lethality1.32814139
60MP0009643_abnormal_urine_homeostasis1.32020738
61MP0009672_abnormal_birth_weight1.31148620
62MP0000747_muscle_weakness1.31092576
63MP0001697_abnormal_embryo_size1.29807432
64MP0000749_muscle_degeneration1.29204024
65MP0000579_abnormal_nail_morphology1.28608664
66MP0002877_abnormal_melanocyte_morpholog1.28003696
67MP0005257_abnormal_intraocular_pressure1.27150746
68MP0006036_abnormal_mitochondrial_physio1.26727649
69MP0000003_abnormal_adipose_tissue1.24835101
70MP0002086_abnormal_extraembryonic_tissu1.24822462
71MP0002796_impaired_skin_barrier1.24010081
72MP0008775_abnormal_heart_ventricle1.23284385
73MP0003646_muscle_fatigue1.21609503
74MP0003221_abnormal_cardiomyocyte_apopto1.21457642
75MP0000762_abnormal_tongue_morphology1.21427782
76MP0003315_abnormal_perineum_morphology1.19602949
77MP0005058_abnormal_lysosome_morphology1.18605605
78MP0006138_congestive_heart_failure1.16139574
79MP0005584_abnormal_enzyme/coenzyme_acti1.15997177
80MP0001544_abnormal_cardiovascular_syste1.15853807
81MP0005385_cardiovascular_system_phenoty1.15853807
82MP0002084_abnormal_developmental_patter1.15733003
83MP0006054_spinal_hemorrhage1.14836611
84MP0000627_abnormal_mammary_gland1.14693320
85MP0010307_abnormal_tumor_latency1.14532463
86MP0001216_abnormal_epidermal_layer1.09979579
87MP0008058_abnormal_DNA_repair1.05801714
88MP0005275_abnormal_skin_tensile1.05801271
89MP0001881_abnormal_mammary_gland1.05175231
90MP0002085_abnormal_embryonic_tissue1.03751085
91MP0004272_abnormal_basement_membrane1.02236893
92MP0000733_abnormal_muscle_development1.02066586
93MP0000598_abnormal_liver_morphology1.00234481
94MP0002697_abnormal_eye_size0.97081883
95MP0002972_abnormal_cardiac_muscle0.96956581
96MP0003950_abnormal_plasma_membrane0.96660310
97MP0000377_abnormal_hair_follicle0.96374851
98MP0004043_abnormal_pH_regulation0.95329611
99MP0004197_abnormal_fetal_growth/weight/0.95301255
100MP0010030_abnormal_orbit_morphology0.94707850
101MP0010368_abnormal_lymphatic_system0.94431631
102MP0003567_abnormal_fetal_cardiomyocyte0.93776201
103MP0002098_abnormal_vibrissa_morphology0.93634045
104MP0005334_abnormal_fat_pad0.93491695
105MP0005621_abnormal_cell_physiology0.92654949
106MP0000467_abnormal_esophagus_morphology0.92653595
107MP0001915_intracranial_hemorrhage0.92507872
108MP0004019_abnormal_vitamin_homeostasis0.92415819
109MP0002060_abnormal_skin_morphology0.92315855
110MP0005409_darkened_coat_color0.91346328
111MP0000358_abnormal_cell_content/0.89492904
112MP0001661_extended_life_span0.88951468
113MP0008260_abnormal_autophagy0.88554359
114MP0000750_abnormal_muscle_regeneration0.88260317
115MP0003186_abnormal_redox_activity0.88135765
116MP0005266_abnormal_metabolism0.87196000
117MP0002078_abnormal_glucose_homeostasis0.87025623
118MP0000013_abnormal_adipose_tissue0.86862453
119MP0004233_abnormal_muscle_weight0.85893393
120MP0005620_abnormal_muscle_contractility0.85686964
121MP0002896_abnormal_bone_mineralization0.85508093
122MP0002396_abnormal_hematopoietic_system0.84127939
123MP0003868_abnormal_feces_composition0.84028016
124MP0001346_abnormal_lacrimal_gland0.82832343
125MP0005384_cellular_phenotype0.82434145
126MP0003091_abnormal_cell_migration0.81532572
127MP0002106_abnormal_muscle_physiology0.81120594
128MP0001727_abnormal_embryo_implantation0.81118303
129MP0000678_abnormal_parathyroid_gland0.81085009
130MP0005501_abnormal_skin_physiology0.80703967
131MP0003786_premature_aging0.79308269
132MP0002970_abnormal_white_adipose0.79258823
133MP0002006_tumorigenesis0.79257055
134MP0002254_reproductive_system_inflammat0.79060020
135MP0000759_abnormal_skeletal_muscle0.78124873
136MP0009053_abnormal_anal_canal0.77591740
137MP0003828_pulmonary_edema0.77348849
138MP0004264_abnormal_extraembryonic_tissu0.77215740
139MP0005623_abnormal_meninges_morphology0.77106423
140MP0000313_abnormal_cell_death0.75519891
141MP0003453_abnormal_keratinocyte_physiol0.75413161
142MP0002166_altered_tumor_susceptibility0.75262874
143MP0003656_abnormal_erythrocyte_physiolo0.75102174
144MP0000604_amyloidosis0.74342548
145MP0009115_abnormal_fat_cell0.73758779
146MP0009780_abnormal_chondrocyte_physiolo0.70548380
147MP0009763_increased_sensitivity_to0.69442674
148MP0006035_abnormal_mitochondrial_morpho0.68683547
149MP0005408_hypopigmentation0.68619232
150MP0003329_amyloid_beta_deposits0.68221942
151MP0003279_aneurysm0.66148158
152MP0004484_altered_response_of0.65148361
153MP0010678_abnormal_skin_adnexa0.64960507
154MP0005023_abnormal_wound_healing0.64419741
155MP0008961_abnormal_basal_metabolism0.64226087
156MP0000537_abnormal_urethra_morphology0.63700889
157MP0002332_abnormal_exercise_endurance0.62640375
158MP0005451_abnormal_body_composition0.62454817

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)4.94069690
2Myoglobinuria (HP:0002913)4.30278552
3Xanthomatosis (HP:0000991)4.21776403
4Intrahepatic cholestasis (HP:0001406)4.20602564
5Deep venous thrombosis (HP:0002625)4.16379380
6Hyperammonemia (HP:0001987)4.05196439
7Ketosis (HP:0001946)4.00867186
8Hyperglycinuria (HP:0003108)3.87957676
9Ketoacidosis (HP:0001993)3.81695061
10Abnormality of fatty-acid metabolism (HP:0004359)3.68049411
11Abnormality of glycine metabolism (HP:0010895)3.62574171
12Abnormality of serine family amino acid metabolism (HP:0010894)3.62574171
13Abnormality of aromatic amino acid family metabolism (HP:0004338)3.57329667
14Abnormality of monocarboxylic acid metabolism (HP:0010996)3.49722343
15Right ventricular cardiomyopathy (HP:0011663)3.40516848
16Exercise-induced muscle cramps (HP:0003710)3.29506729
17Rhabdomyolysis (HP:0003201)3.21211793
18Hypoalphalipoproteinemia (HP:0003233)3.21055157
19Abnormality of dicarboxylic acid metabolism (HP:0010995)3.20248122
20Dicarboxylic aciduria (HP:0003215)3.20248122
21Hyporeflexia of lower limbs (HP:0002600)3.19564699
22Premature rupture of membranes (HP:0001788)3.11710260
23Abnormality of glycolysis (HP:0004366)3.03674416
24Hypobetalipoproteinemia (HP:0003563)3.02134513
25Hypolipoproteinemia (HP:0010981)3.00321791
26Epidermoid cyst (HP:0200040)3.00158054
27Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.96778092
28Hyperlipoproteinemia (HP:0010980)2.93380294
29Hyperglycinemia (HP:0002154)2.89384146
30Abnormality of glutamine family amino acid metabolism (HP:0010902)2.89376431
31Increased connective tissue (HP:0009025)2.88694192
32Complement deficiency (HP:0004431)2.84727717
33Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.82518704
34Spastic diplegia (HP:0001264)2.81443420
35Ankyloglossia (HP:0010296)2.80272014
36Abnormality of sulfur amino acid metabolism (HP:0004339)2.76719406
37Protrusio acetabuli (HP:0003179)2.71295134
38Abnormality of aspartate family amino acid metabolism (HP:0010899)2.70885314
39Flat acetabular roof (HP:0003180)2.70144356
40Asymmetry of the thorax (HP:0001555)2.65504384
41Hyperacusis (HP:0010780)2.65463878
42Hyperinsulinemic hypoglycemia (HP:0000825)2.65347792
43Skin nodule (HP:0200036)2.63889676
44Increased serum pyruvate (HP:0003542)2.63799246
45Sudden death (HP:0001699)2.62162498
46Osteolytic defects of the phalanges of the hand (HP:0009771)2.60697686
47Osteolytic defects of the hand bones (HP:0009699)2.60697686
48Abnormality of the distal phalanges of the toes (HP:0010182)2.59875091
49Ventricular tachycardia (HP:0004756)2.59022022
50Exercise-induced myalgia (HP:0003738)2.55011463
51Difficulty running (HP:0009046)2.54436646
52Termporal pattern (HP:0011008)2.53894325
53Insidious onset (HP:0003587)2.53894325
54Vertebral compression fractures (HP:0002953)2.50710867
55Abnormality of the common coagulation pathway (HP:0010990)2.47657742
56Deviation of the thumb (HP:0009603)2.45048755
57Hypercholesterolemia (HP:0003124)2.44095194
58Progressive muscle weakness (HP:0003323)2.43946850
59Abnormality of oral frenula (HP:0000190)2.41538395
60Short nail (HP:0001799)2.39057143
61Abnormality of the intrinsic pathway (HP:0010989)2.38612935
62Abnormality of methionine metabolism (HP:0010901)2.38430481
63Conjunctival hamartoma (HP:0100780)2.36263216
64Chromsome breakage (HP:0040012)2.34247485
65Metabolic acidosis (HP:0001942)2.33984224
66Hypoglycemic seizures (HP:0002173)2.33517579
67Chromosomal breakage induced by crosslinking agents (HP:0003221)2.30529975
68Generalized aminoaciduria (HP:0002909)2.27594924
69Cholecystitis (HP:0001082)2.27255466
70Abnormal gallbladder physiology (HP:0012438)2.27255466
71Trismus (HP:0000211)2.26520013
72Increased nuchal translucency (HP:0010880)2.26255248
73Proximal placement of thumb (HP:0009623)2.24998769
74Asymmetric septal hypertrophy (HP:0001670)2.24442418
75Selective tooth agenesis (HP:0001592)2.22402261
76Prolonged partial thromboplastin time (HP:0003645)2.22043345
77Myocardial infarction (HP:0001658)2.21280607
78Abnormality of the umbilical cord (HP:0010881)2.19234260
79Cholelithiasis (HP:0001081)2.19003453
80Abnormality of purine metabolism (HP:0004352)2.17828393
81Insomnia (HP:0100785)2.17600277
82Muscle fiber splitting (HP:0003555)2.16376436
83Proximal tubulopathy (HP:0000114)2.14661630
84Abnormality of the Achilles tendon (HP:0005109)2.14282158
85Global brain atrophy (HP:0002283)2.14033830
86Centrally nucleated skeletal muscle fibers (HP:0003687)2.13879194
87Abnormality of serum amino acid levels (HP:0003112)2.13441624
88Abnormality of proline metabolism (HP:0010907)2.11879229
89Hydroxyprolinuria (HP:0003080)2.11879229
90Septate vagina (HP:0001153)2.10798258
91Breech presentation (HP:0001623)2.10481837
92Advanced eruption of teeth (HP:0006288)2.10416133
93Increased muscle lipid content (HP:0009058)2.09229257
94Lipoatrophy (HP:0100578)2.09217631
95Deep philtrum (HP:0002002)2.07934311
96Esophageal varix (HP:0002040)2.06910747
97Hepatocellular carcinoma (HP:0001402)2.06325987
98Lymphangioma (HP:0100764)2.06061471
99Abnormal gallbladder morphology (HP:0012437)2.05155682
100Distal lower limb amyotrophy (HP:0008944)2.04300096
101Ragged-red muscle fibers (HP:0003200)2.04233792
102Multiple enchondromatosis (HP:0005701)2.03966986
103Acanthosis nigricans (HP:0000956)2.03867494
104Late onset (HP:0003584)2.03452497
105Abnormality of complement system (HP:0005339)2.02573996
106Nausea (HP:0002018)2.01382879
107Palpitations (HP:0001962)2.01119494
108Abnormal cartilage morphology (HP:0002763)2.00136537
109Microvesicular hepatic steatosis (HP:0001414)1.99285730
110Progressive external ophthalmoplegia (HP:0000590)1.98961785
111Overlapping toe (HP:0001845)1.98137325
112Orthostatic hypotension (HP:0001278)1.98004148
113Dilated cardiomyopathy (HP:0001644)1.97177217
114Increased mean platelet volume (HP:0011877)1.97123297
115Cerebral edema (HP:0002181)1.96621542
116Hypertriglyceridemia (HP:0002155)1.96488746
117Muscle stiffness (HP:0003552)1.94909209
118Fat malabsorption (HP:0002630)1.94103765
119Lethargy (HP:0001254)1.93936305
120Abnormalities of placenta or umbilical cord (HP:0001194)1.93596038
121Abnormality of nucleobase metabolism (HP:0010932)1.93451732
122Gout (HP:0001997)1.92932903
123Resting tremor (HP:0002322)1.92519653
124Sparse lateral eyebrow (HP:0005338)1.90916438
125Natal tooth (HP:0000695)1.89883136
126Hamartoma of the eye (HP:0010568)1.89188114
127Abnormality of the calcaneus (HP:0008364)1.87719483
128Reticulocytosis (HP:0001923)1.86426944
129Pterygium (HP:0001059)1.86394118
130Missing ribs (HP:0000921)1.85022927
131Hyperglycemia (HP:0003074)1.84914545
132Abnormality of the acetabulum (HP:0003170)1.84830316
133Pili torti (HP:0003777)1.84298210
134Hyperbilirubinemia (HP:0002904)1.83711234
135Abnormal foot bone ossification (HP:0010675)1.83574800
136Cerebral aneurysm (HP:0004944)1.83549930
137Abnormality of carpal bone ossification (HP:0006257)1.82470255
138Dysmetric saccades (HP:0000641)1.82121010
139Achilles tendon contracture (HP:0001771)1.81945586
140Microglossia (HP:0000171)1.81595544
141Neonatal onset (HP:0003623)1.81531863
142Ulnar bowing (HP:0003031)1.80299722
143Vomiting (HP:0002013)1.80175515
144Distal lower limb muscle weakness (HP:0009053)1.78357155
145Entropion (HP:0000621)1.74854945
146Hyperuricemia (HP:0002149)1.74485230
147Increased purine levels (HP:0004368)1.74485230
148Abnormality of nail color (HP:0100643)1.73554206
149Abnormal umbilical cord blood vessels (HP:0011403)1.72929975
150Single umbilical artery (HP:0001195)1.72929975
151Abnormality of the fetal cardiovascular system (HP:0010948)1.72929975
152Limb-girdle muscle atrophy (HP:0003797)1.72776384
153Relative macrocephaly (HP:0004482)1.72176261
154Joint hemorrhage (HP:0005261)1.71336590
155Spinal rigidity (HP:0003306)1.69868585
156Aneurysm (HP:0002617)1.69641714
157Broad metatarsal (HP:0001783)1.69595274
158Back pain (HP:0003418)1.69122610
159Hepatic necrosis (HP:0002605)1.68809321
160Abnormal platelet volume (HP:0011876)1.68735428
161Elbow flexion contracture (HP:0002987)1.68597180
162Increased variability in muscle fiber diameter (HP:0003557)1.68163231
163Neonatal death (HP:0003811)1.67341880
164Unilateral renal agenesis (HP:0000122)1.64946684
165Spinal cord compression (HP:0002176)1.64265001
166Abnormality of pain sensation (HP:0010832)1.63625224
167Impaired pain sensation (HP:0007328)1.63625224
168Atrophic scars (HP:0001075)1.63092197
169Onycholysis (HP:0001806)1.62598912
170Pseudobulbar signs (HP:0002200)1.62189255
171Hypokinesia (HP:0002375)1.61864903
172Cervical subluxation (HP:0003308)1.61138463
173Abnormality of the salivary glands (HP:0010286)1.60880490
174Renal duplication (HP:0000075)1.60403661
175Arterial tortuosity (HP:0005116)1.60196795
176Abnormal tarsal ossification (HP:0008369)1.58830806
177Abnormality of the tricuspid valve (HP:0001702)1.57942812
178Abnormal delivery (HP:0001787)1.57856910
179Overriding aorta (HP:0002623)1.57174473
180Wormian bones (HP:0002645)1.56752483
181Ridged nail (HP:0001807)1.56273313
182Fragile skin (HP:0001030)1.54214890
183Ankle contracture (HP:0006466)1.53704808
184Abnormal ossification of hand bones (HP:0005921)1.53662527
185Abnormal hair laboratory examination (HP:0003328)1.51690569

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.79615347
2PKN24.59952582
3BCKDK3.58164545
4TTN3.37243105
5EIF2AK12.70334121
6PBK2.67670472
7SIK12.51911864
8SMG12.25927737
9PDK42.20006849
10PDK32.20006849
11EEF2K2.18993682
12FLT32.15403062
13SRPK12.06310887
14BUB12.05353706
15NME22.03554305
16TSSK62.02524056
17FGFR41.99227046
18LMTK21.92573555
19PTK61.90690640
20LATS21.90594166
21CAMK1D1.87421380
22RIPK11.83118920
23MET1.70535082
24IRAK31.69869918
25ERN11.69652997
26MST1R1.57742161
27SCYL21.55326082
28CDC71.54060634
29CDK121.53673244
30DMPK1.53483148
31PDGFRA1.51008330
32EPHB11.49646982
33LRRK21.41423740
34FGFR21.37012227
35WEE11.34034750
36CDK61.30020474
37MAP3K101.29669085
38NEK11.29438113
39CDK71.20467299
40MAP3K71.20269169
41EIF2AK31.19394421
42RPS6KB21.18703702
43ERBB41.17719834
44OBSCN1.12696738
45MAP2K31.12490379
46CAMK1G1.11508067
47INSRR1.08360734
48NEK91.06889636
49LATS11.06512417
50CDK41.04890173
51MAP3K21.04640692
52PDK21.02047260
53TESK11.01078394
54BMX0.98118250
55TIE10.94818522
56FGFR30.94555219
57AURKB0.94285742
58RET0.92389234
59MTOR0.89724174
60BRSK10.85326276
61BRD40.84991874
62CHEK20.84492780
63FRK0.84192495
64PRKAA20.83671459
65PLK10.82991660
66CHEK10.82718547
67FER0.82144964
68BRSK20.80148393
69NEK20.79410158
70PRPF4B0.79232895
71MAPK110.78017018
72KSR20.77910703
73PHKG10.75459458
74PHKG20.75459458
75STK100.75290812
76JAK20.74908755
77TGFBR20.74658876
78MAP3K90.74160672
79PAK20.74075877
80MAP3K80.73702043
81WNK40.73338699
82ILK0.72404486
83ARAF0.71536309
84MAP2K10.71246498
85TGFBR10.69775560
86PLK30.68372374
87FGFR10.68345215
88JAK10.68146508
89NEK60.68131254
90TYK20.68083832
91TRPM70.66882106
92CCNB10.65034350
93CDK90.64983333
94PDK10.64657482
95RPS6KA40.64270389
96PIK3CA0.63834263
97PAK40.63290264
98PDPK10.63286231
99ATR0.62911068
100KDR0.61246764
101PRKD10.59552579
102PIK3CG0.58764692
103ALK0.57503058
104PTK20.56864422
105ICK0.56725395
106BRAF0.56068367
107GSK3A0.54799755
108LIMK10.54164231
109PRKD30.53953270
110STK30.53770413
111MAP3K30.53481374
112PDGFRB0.53377501
113PAK30.52330442
114MAP3K140.52271601
115MAP3K120.52097356
116KSR10.51751608
117MYLK0.51395867
118AURKA0.51379219
119EPHA20.50676843
120MKNK10.49784330
121EIF2AK20.49782281
122RAF10.49555137
123CLK10.48859281
124GRK60.48345087
125CDK10.48172497
126ERBB30.48007639
127PRKAA10.47117875
128MAP2K20.46986138
129CDK80.46896421
130MAP3K130.46487396
131ATM0.45920477
132BCR0.44833232
133AKT20.43409837
134CDK20.42287426
135NTRK10.41871328
136MELK0.41791145
137PNCK0.41697881
138MAPKAPK30.40564620
139PRKCH0.40067164
140STK390.38974331
141CSNK1E0.37143979
142STK40.36955236
143TTK0.35615368
144PRKACG0.33472222
145EGFR0.32750127
146JAK30.30891501
147TAOK30.30783997
148INSR0.30162714
149MST40.29163128
150CSK0.29156830

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid degradation_Homo sapiens_hsa000713.44737581
2Nitrogen metabolism_Homo sapiens_hsa009103.34271953
3Propanoate metabolism_Homo sapiens_hsa006403.34186151
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.31991980
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.28031764
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.06970099
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.85678275
8* Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.83169790
9DNA replication_Homo sapiens_hsa030302.79973885
10Fatty acid metabolism_Homo sapiens_hsa012122.74435254
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.67928423
12Primary bile acid biosynthesis_Homo sapiens_hsa001202.57992800
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.43777033
14Arginine biosynthesis_Homo sapiens_hsa002202.38482255
15PPAR signaling pathway_Homo sapiens_hsa033202.28641158
16Tryptophan metabolism_Homo sapiens_hsa003802.23395093
17Carbon metabolism_Homo sapiens_hsa012002.22783932
18Butanoate metabolism_Homo sapiens_hsa006502.20623158
19Pyruvate metabolism_Homo sapiens_hsa006202.19249613
20Mismatch repair_Homo sapiens_hsa034302.13024383
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.01464472
22Cell cycle_Homo sapiens_hsa041101.83609708
23Non-homologous end-joining_Homo sapiens_hsa034501.72190258
24beta-Alanine metabolism_Homo sapiens_hsa004101.70995442
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.69643119
26Vitamin B6 metabolism_Homo sapiens_hsa007501.67984836
27RNA transport_Homo sapiens_hsa030131.66367110
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.61577092
29Nucleotide excision repair_Homo sapiens_hsa034201.60899832
30Peroxisome_Homo sapiens_hsa041461.59200995
31Fatty acid elongation_Homo sapiens_hsa000621.56510454
32Biosynthesis of amino acids_Homo sapiens_hsa012301.54880429
33Fatty acid biosynthesis_Homo sapiens_hsa000611.52957370
34Caffeine metabolism_Homo sapiens_hsa002321.51597067
35Complement and coagulation cascades_Homo sapiens_hsa046101.49014490
36Starch and sucrose metabolism_Homo sapiens_hsa005001.48222121
37Selenocompound metabolism_Homo sapiens_hsa004501.45724650
38Pentose and glucuronate interconversions_Homo sapiens_hsa000401.45461838
39Spliceosome_Homo sapiens_hsa030401.41788305
40Lysine degradation_Homo sapiens_hsa003101.41586268
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.40442471
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.36017515
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.31219355
44Bile secretion_Homo sapiens_hsa049761.30493246
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.27056238
46Base excision repair_Homo sapiens_hsa034101.26172528
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.24465862
48Fat digestion and absorption_Homo sapiens_hsa049751.23328468
49Sulfur metabolism_Homo sapiens_hsa009201.22682277
50Histidine metabolism_Homo sapiens_hsa003401.20245201
51N-Glycan biosynthesis_Homo sapiens_hsa005101.18110965
52Phenylalanine metabolism_Homo sapiens_hsa003601.17876888
53Tyrosine metabolism_Homo sapiens_hsa003501.16500959
54Chronic myeloid leukemia_Homo sapiens_hsa052201.15218551
55mRNA surveillance pathway_Homo sapiens_hsa030151.12907585
56Chemical carcinogenesis_Homo sapiens_hsa052041.09959870
57Other glycan degradation_Homo sapiens_hsa005111.08322921
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.05950215
59Glycerolipid metabolism_Homo sapiens_hsa005611.00986087
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00279321
61Cysteine and methionine metabolism_Homo sapiens_hsa002701.00042681
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.98782376
63ABC transporters_Homo sapiens_hsa020100.98656144
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.97723477
65Cyanoamino acid metabolism_Homo sapiens_hsa004600.97580180
66Pancreatic cancer_Homo sapiens_hsa052120.95693013
67Insulin resistance_Homo sapiens_hsa049310.92351587
68Proteasome_Homo sapiens_hsa030500.91770179
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.90768908
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89762578
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.88774973
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.83661035
73One carbon pool by folate_Homo sapiens_hsa006700.81507796
74Arginine and proline metabolism_Homo sapiens_hsa003300.78170166
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.77681932
76Non-small cell lung cancer_Homo sapiens_hsa052230.76547507
77AMPK signaling pathway_Homo sapiens_hsa041520.76487753
78Pyrimidine metabolism_Homo sapiens_hsa002400.74648845
79Endometrial cancer_Homo sapiens_hsa052130.74415400
80Staphylococcus aureus infection_Homo sapiens_hsa051500.72057162
81Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69570924
82MicroRNAs in cancer_Homo sapiens_hsa052060.68652216
83Retinol metabolism_Homo sapiens_hsa008300.68122798
84Pentose phosphate pathway_Homo sapiens_hsa000300.65302723
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65247204
86Glucagon signaling pathway_Homo sapiens_hsa049220.65113333
87Oocyte meiosis_Homo sapiens_hsa041140.64712459
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63221244
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.61208122
90Prostate cancer_Homo sapiens_hsa052150.61045494
91Vibrio cholerae infection_Homo sapiens_hsa051100.60495378
92Renal cell carcinoma_Homo sapiens_hsa052110.59864478
93Folate biosynthesis_Homo sapiens_hsa007900.59482941
94Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.59433864
95p53 signaling pathway_Homo sapiens_hsa041150.59237393
96Insulin signaling pathway_Homo sapiens_hsa049100.58264504
97Galactose metabolism_Homo sapiens_hsa000520.58186145
98Prion diseases_Homo sapiens_hsa050200.58050791
99Hippo signaling pathway_Homo sapiens_hsa043900.55825841
100Glutathione metabolism_Homo sapiens_hsa004800.54229316
101Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53817702
102Sulfur relay system_Homo sapiens_hsa041220.52731096
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51324319
104Maturity onset diabetes of the young_Homo sapiens_hsa049500.51147065
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49179015
106Viral carcinogenesis_Homo sapiens_hsa052030.48456489
107Colorectal cancer_Homo sapiens_hsa052100.44456990
108Glycosaminoglycan degradation_Homo sapiens_hsa005310.44427475
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41784639
110Glioma_Homo sapiens_hsa052140.41464848
111Fructose and mannose metabolism_Homo sapiens_hsa000510.40801839
112Vitamin digestion and absorption_Homo sapiens_hsa049770.39253872
113Sphingolipid metabolism_Homo sapiens_hsa006000.37463324
114Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.37028892
115Fanconi anemia pathway_Homo sapiens_hsa034600.36453629
116Dilated cardiomyopathy_Homo sapiens_hsa054140.35431294
117Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.35102332
118Metabolic pathways_Homo sapiens_hsa011000.32083105
119Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.31979393
120Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.29958651
121Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28857362
122ECM-receptor interaction_Homo sapiens_hsa045120.28222467
123mTOR signaling pathway_Homo sapiens_hsa041500.26221570
124Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.25451284
125Focal adhesion_Homo sapiens_hsa045100.24960357
126Adherens junction_Homo sapiens_hsa045200.24790290
127Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.19552122
128Steroid biosynthesis_Homo sapiens_hsa001000.19241773
129Proteoglycans in cancer_Homo sapiens_hsa052050.18636176
130HIF-1 signaling pathway_Homo sapiens_hsa040660.15302314
131Tight junction_Homo sapiens_hsa045300.15236773
132Carbohydrate digestion and absorption_Homo sapiens_hsa049730.14224793
133Viral myocarditis_Homo sapiens_hsa054160.14118043
134Small cell lung cancer_Homo sapiens_hsa052220.12428124
135Amoebiasis_Homo sapiens_hsa051460.12321389
136Cardiac muscle contraction_Homo sapiens_hsa042600.10776273
137alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.09365637
138Thyroid cancer_Homo sapiens_hsa052160.08700758
139Protein digestion and absorption_Homo sapiens_hsa049740.08522444
140Bladder cancer_Homo sapiens_hsa052190.08345019
141Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.07277592
142Renin-angiotensin system_Homo sapiens_hsa046140.07101454
143Longevity regulating pathway - mammal_Homo sapiens_hsa042110.05246899

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