ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.92315070
2	response to pheromone (GO:0019236)	4.48674034
3	water-soluble vitamin biosynthetic process (GO:0042364)	4.11750027
4	protein-cofactor linkage (GO:0018065)	4.11055661
5	maturation of 5.8S rRNA (GO:0000460)	4.03204371
6	DNA deamination (GO:0045006)	4.01451376
7	adaptation of signaling pathway (GO:0023058)	3.90429040
8	platelet dense granule organization (GO:0060155)	3.88116103
9	negative regulation of protein oligomerization (GO:0032460)	3.85852341
10	fucose catabolic process (GO:0019317)	3.84619972
11	L-fucose metabolic process (GO:0042354)	3.84619972
12	L-fucose catabolic process (GO:0042355)	3.84619972
13	negative regulation of telomere maintenance (GO:0032205)	3.79204324
14	protein import into peroxisome matrix (GO:0016558)	3.78772324
15	nucleotide transmembrane transport (GO:1901679)	3.62194137
16	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.53136523
17	epithelial cilium movement (GO:0003351)	3.47915678
18	regulation of cilium movement (GO:0003352)	3.38021175
19	indolalkylamine metabolic process (GO:0006586)	3.35249471
20	behavioral response to ethanol (GO:0048149)	3.30401270
21	pyrimidine nucleobase catabolic process (GO:0006208)	3.27639649
22	axoneme assembly (GO:0035082)	3.22019795
23	regulation of hexokinase activity (GO:1903299)	3.21050379
24	regulation of glucokinase activity (GO:0033131)	3.21050379
25	kidney morphogenesis (GO:0060993)	3.20472184
26	gamma-aminobutyric acid transport (GO:0015812)	3.19780280
27	retinal cone cell development (GO:0046549)	3.18029517
28	indole-containing compound catabolic process (GO:0042436)	3.15516836
29	indolalkylamine catabolic process (GO:0046218)	3.15516836
30	tryptophan catabolic process (GO:0006569)	3.15516836
31	sulfation (GO:0051923)	3.11731450
32	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.09530149
33	detection of light stimulus involved in visual perception (GO:0050908)	3.06793279
34	detection of light stimulus involved in sensory perception (GO:0050962)	3.06793279
35	cornea development in camera-type eye (GO:0061303)	3.06201723
36	nonmotile primary cilium assembly (GO:0035058)	3.03189427
37	protein polyglutamylation (GO:0018095)	3.01520836
38	piRNA metabolic process (GO:0034587)	3.01006657
39	rRNA catabolic process (GO:0016075)	2.98911475
40	glycerophospholipid catabolic process (GO:0046475)	2.98598843
41	respiratory chain complex IV assembly (GO:0008535)	2.92818141
42	nucleobase catabolic process (GO:0046113)	2.91593848
43	tryptophan metabolic process (GO:0006568)	2.87199835
44	neural tube formation (GO:0001841)	2.86817595
45	protein localization to cilium (GO:0061512)	2.86217301
46	cellular ketone body metabolic process (GO:0046950)	2.86072611
47	negative regulation of mast cell activation (GO:0033004)	2.81340418
48	transmission of nerve impulse (GO:0019226)	2.81077992
49	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.78975703
50	protein localization to peroxisome (GO:0072662)	2.76549390
51	protein targeting to peroxisome (GO:0006625)	2.76549390
52	establishment of protein localization to peroxisome (GO:0072663)	2.76549390
53	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.76146656
54	limb bud formation (GO:0060174)	2.75186927
55	cilium morphogenesis (GO:0060271)	2.74904161
56	DNA double-strand break processing (GO:0000729)	2.74099246
57	rhodopsin mediated signaling pathway (GO:0016056)	2.73228597
58	cilium movement (GO:0003341)	2.72656802
59	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.71405866
60	kynurenine metabolic process (GO:0070189)	2.69196768
61	synaptic transmission, cholinergic (GO:0007271)	2.69150011
62	neuronal action potential (GO:0019228)	2.67485204
63	presynaptic membrane assembly (GO:0097105)	2.67136165
64	amine catabolic process (GO:0009310)	2.67035807
65	cellular biogenic amine catabolic process (GO:0042402)	2.67035807
66	cilium or flagellum-dependent cell motility (GO:0001539)	2.65581769
67	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.64793513
68	intraciliary transport (GO:0042073)	2.64682594
69	photoreceptor cell maintenance (GO:0045494)	2.64648344
70	protein K11-linked deubiquitination (GO:0035871)	2.61546047
71	photoreceptor cell development (GO:0042461)	2.61522338
72	protein complex biogenesis (GO:0070271)	2.60916563
73	regulation of telomere maintenance (GO:0032204)	2.60481825
74	dopamine transport (GO:0015872)	2.59463613
75	intracellular protein transmembrane import (GO:0044743)	2.59167741
76	cytochrome complex assembly (GO:0017004)	2.58329403
77	reflex (GO:0060004)	2.58184425
78	indole-containing compound metabolic process (GO:0042430)	2.57304082
79	cilium organization (GO:0044782)	2.57269513
80	preassembly of GPI anchor in ER membrane (GO:0016254)	2.55978826
81	ketone body metabolic process (GO:1902224)	2.55104448
82	ubiquinone biosynthetic process (GO:0006744)	2.53414217
83	cilium assembly (GO:0042384)	2.52080912
84	DNA methylation involved in gamete generation (GO:0043046)	2.51947922
85	somite development (GO:0061053)	2.50740338
86	regulation of neurotransmitter uptake (GO:0051580)	2.50066971
87	L-methionine salvage (GO:0071267)	2.45045655
88	L-methionine biosynthetic process (GO:0071265)	2.45045655
89	amino acid salvage (GO:0043102)	2.45045655
90	exogenous drug catabolic process (GO:0042738)	2.44364755
91	inositol phosphate catabolic process (GO:0071545)	2.44257558
92	drug catabolic process (GO:0042737)	2.43670724
93	presynaptic membrane organization (GO:0097090)	2.41374742
94	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.39268092
95	neuronal action potential propagation (GO:0019227)	2.39191156
96	S-adenosylmethionine metabolic process (GO:0046500)	2.37814578
97	proline transport (GO:0015824)	2.37546708
98	recombinational repair (GO:0000725)	2.36573786
99	regulation of action potential (GO:0098900)	2.36215414
100	inner ear receptor stereocilium organization (GO:0060122)	2.34992629

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.94002424
2	VDR_22108803_ChIP-Seq_LS180_Human	3.24671630
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.11505429
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.02094357
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.65052069
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.61933551
7	EZH2_22144423_ChIP-Seq_EOC_Human	2.49496654
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.47588007
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.33094387
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.29803638
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.22889686
12	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.14003201
13	P300_19829295_ChIP-Seq_ESCs_Human	2.04717258
14	EWS_26573619_Chip-Seq_HEK293_Human	2.02822060
15	TAF15_26573619_Chip-Seq_HEK293_Human	2.00827967
16	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.98131663
17	FUS_26573619_Chip-Seq_HEK293_Human	1.89938299
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.80360901
19	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.80245058
20	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.74820975
21	ER_23166858_ChIP-Seq_MCF-7_Human	1.70309839
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.69530789
23	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.67501905
24	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.67436049
25	BCAT_22108803_ChIP-Seq_LS180_Human	1.65007421
26	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.64141910
27	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.60171639
28	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.57030879
29	REST_21632747_ChIP-Seq_MESCs_Mouse	1.56778603
30	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.55250902
31	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.53021450
32	AR_25329375_ChIP-Seq_VCAP_Human	1.52468342
33	STAT3_23295773_ChIP-Seq_U87_Human	1.51553318
34	CBP_20019798_ChIP-Seq_JUKART_Human	1.51344874
35	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.51344874
36	SMAD4_21799915_ChIP-Seq_A2780_Human	1.50842175
37	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.49195171
38	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.48856312
39	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.48134995
40	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.46525352
41	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.45752466
42	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.45634727
43	IRF1_19129219_ChIP-ChIP_H3396_Human	1.44767580
44	TP53_22573176_ChIP-Seq_HFKS_Human	1.43172430
45	TCF4_23295773_ChIP-Seq_U87_Human	1.42843295
46	SOX2_19829295_ChIP-Seq_ESCs_Human	1.39891428
47	NANOG_19829295_ChIP-Seq_ESCs_Human	1.39891428
48	RNF2_27304074_Chip-Seq_NSC_Mouse	1.38163243
49	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.35957708
50	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.34507788
51	TCF4_22108803_ChIP-Seq_LS180_Human	1.34330133
52	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.33938744
53	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.33914362
54	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.31456042
55	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.30629363
56	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.30629363
57	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.29972922
58	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.29068864
59	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.28607211
60	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.28434822
61	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.26992150
62	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.26865884
63	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.26161638
64	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.24674936
65	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.23551464
66	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.22211745
67	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.21738131
68	RUNX2_22187159_ChIP-Seq_PCA_Human	1.20694326
69	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.19904590
70	NCOR_22424771_ChIP-Seq_293T_Human	1.18312046
71	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.18152221
72	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.18010003
73	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.18010003
74	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.16657722
75	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.14256384
76	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.13175291
77	AR_20517297_ChIP-Seq_VCAP_Human	1.12798598
78	MYC_18940864_ChIP-ChIP_HL60_Human	1.10573626
79	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.10414268
80	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.10316263
81	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.09911997
82	P53_22387025_ChIP-Seq_ESCs_Mouse	1.09502286
83	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.09370887
84	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.09127840
85	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.07516719
86	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.07324642
87	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.07084402
88	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.06439899
89	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.06110241
90	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.02560252
91	HOXB7_26014856_ChIP-Seq_BT474_Human	1.00536819
92	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.99970618
93	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.99452972
94	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.97874214
95	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.97216084
96	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.97125424
97	AR_21572438_ChIP-Seq_LNCaP_Human	0.96327870
98	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.96079569
99	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.95886789
100	JUN_21703547_ChIP-Seq_K562_Human	0.95823714

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	3.10969561
2	MP0002254_reproductive_system_inflammat	3.07344549
3	MP0002837_dystrophic_cardiac_calcinosis	3.03996249
4	MP0002876_abnormal_thyroid_physiology	2.74608263
5	MP0008877_abnormal_DNA_methylation	2.68180634
6	MP0003880_abnormal_central_pattern	2.60991721
7	MP0003195_calcinosis	2.30590350
8	MP0005551_abnormal_eye_electrophysiolog	2.30310205
9	MP0005645_abnormal_hypothalamus_physiol	2.23098889
10	MP0009046_muscle_twitch	2.10156556
11	MP0002102_abnormal_ear_morphology	2.09187636
12	MP0006276_abnormal_autonomic_nervous	2.01446453
13	MP0005646_abnormal_pituitary_gland	1.98886728
14	MP0001968_abnormal_touch/_nociception	1.98361009
15	MP0006072_abnormal_retinal_apoptosis	1.95957379
16	MP0001984_abnormal_olfaction	1.95137217
17	MP0006292_abnormal_olfactory_placode	1.89193056
18	MP0003787_abnormal_imprinting	1.87217808
19	MP0009745_abnormal_behavioral_response	1.80213722
20	MP0001501_abnormal_sleep_pattern	1.79357798
21	MP0000631_abnormal_neuroendocrine_gland	1.73979491
22	MP0005253_abnormal_eye_physiology	1.73197411
23	MP0003646_muscle_fatigue	1.72810048
24	MP0002736_abnormal_nociception_after	1.71341658
25	MP0004133_heterotaxia	1.68584718
26	MP0002272_abnormal_nervous_system	1.64074476
27	MP0003011_delayed_dark_adaptation	1.63757034
28	MP0008872_abnormal_physiological_respon	1.62329491
29	MP0002653_abnormal_ependyma_morphology	1.57899258
30	MP0004885_abnormal_endolymph	1.56350453
31	MP0000427_abnormal_hair_cycle	1.55748628
32	MP0001986_abnormal_taste_sensitivity	1.55386744
33	MP0006082_CNS_inflammation	1.50968980
34	MP0002638_abnormal_pupillary_reflex	1.50947004
35	MP0004142_abnormal_muscle_tone	1.49154728
36	MP0003136_yellow_coat_color	1.45383132
37	MP0000372_irregular_coat_pigmentation	1.44638142
38	MP0005084_abnormal_gallbladder_morpholo	1.42424332
39	MP0002909_abnormal_adrenal_gland	1.39675800
40	MP0002938_white_spotting	1.37868326
41	MP0008789_abnormal_olfactory_epithelium	1.36670144
42	MP0001529_abnormal_vocalization	1.32489486
43	MP0001486_abnormal_startle_reflex	1.32446786
44	MP0004043_abnormal_pH_regulation	1.32123443
45	MP0002064_seizures	1.31603157
46	MP0002751_abnormal_autonomic_nervous	1.27245687
47	MP0002557_abnormal_social/conspecific_i	1.27011542
48	MP0002572_abnormal_emotion/affect_behav	1.25333727
49	MP0002163_abnormal_gland_morphology	1.23379703
50	MP0005379_endocrine/exocrine_gland_phen	1.22809829
51	MP0002234_abnormal_pharynx_morphology	1.22512217
52	MP0003283_abnormal_digestive_organ	1.18725739
53	MP0002277_abnormal_respiratory_mucosa	1.17915368
54	MP0005174_abnormal_tail_pigmentation	1.15121429
55	MP0002735_abnormal_chemical_nociception	1.13275939
56	MP0008875_abnormal_xenobiotic_pharmacok	1.12711213
57	MP0000778_abnormal_nervous_system	1.11309653
58	MP0001970_abnormal_pain_threshold	1.09112622
59	MP0001485_abnormal_pinna_reflex	1.09048107
60	MP0003122_maternal_imprinting	1.08696371
61	MP0003635_abnormal_synaptic_transmissio	1.08228112
62	MP0002733_abnormal_thermal_nociception	1.07979778
63	MP0008058_abnormal_DNA_repair	1.05298544
64	MP0002693_abnormal_pancreas_physiology	1.05032031
65	MP0002067_abnormal_sensory_capabilities	1.02457321
66	MP0003121_genomic_imprinting	1.02451815
67	MP0000230_abnormal_systemic_arterial	1.01038480
68	MP0002063_abnormal_learning/memory/cond	0.99728696
69	MP0005195_abnormal_posterior_eye	0.97187919
70	MP0004742_abnormal_vestibular_system	0.96877162
71	MP0002095_abnormal_skin_pigmentation	0.96391763
72	MP0001905_abnormal_dopamine_level	0.96180761
73	MP0003718_maternal_effect	0.95300632
74	MP0004147_increased_porphyrin_level	0.94851994
75	MP0005389_reproductive_system_phenotype	0.94609146
76	MP0002160_abnormal_reproductive_system	0.94545816
77	MP0005410_abnormal_fertilization	0.93448906
78	MP0005394_taste/olfaction_phenotype	0.92950513
79	MP0005499_abnormal_olfactory_system	0.92950513
80	MP0002928_abnormal_bile_duct	0.92797649
81	MP0010386_abnormal_urinary_bladder	0.91566797
82	MP0002184_abnormal_innervation	0.90796452
83	MP0002229_neurodegeneration	0.90408622
84	MP0000015_abnormal_ear_pigmentation	0.89477095
85	MP0001944_abnormal_pancreas_morphology	0.88783682
86	MP0002752_abnormal_somatic_nervous	0.87951047
87	MP0002734_abnormal_mechanical_nocicepti	0.86871925
88	MP0001873_stomach_inflammation	0.86770212
89	MP0000383_abnormal_hair_follicle	0.86292454
90	MP0004215_abnormal_myocardial_fiber	0.85367383
91	MP0003698_abnormal_male_reproductive	0.84896555
92	MP0005423_abnormal_somatic_nervous	0.82672345
93	MP0005075_abnormal_melanosome_morpholog	0.82607445
94	MP0005386_behavior/neurological_phenoty	0.79310053
95	MP0004924_abnormal_behavior	0.79310053
96	MP0000026_abnormal_inner_ear	0.77629189
97	MP0005167_abnormal_blood-brain_barrier	0.77251658
98	MP0008995_early_reproductive_senescence	0.76322696
99	MP0004085_abnormal_heartbeat	0.75993891
100	MP0005171_absent_coat_pigmentation	0.75639144

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.29058521
2	True hermaphroditism (HP:0010459)	3.95601947
3	Pancreatic fibrosis (HP:0100732)	3.87881715
4	Nephronophthisis (HP:0000090)	3.61970584
5	Abnormality of midbrain morphology (HP:0002418)	3.50965349
6	Molar tooth sign on MRI (HP:0002419)	3.50965349
7	Congenital stationary night blindness (HP:0007642)	3.50201621
8	Abnormality of the renal cortex (HP:0011035)	3.43842214
9	Medial flaring of the eyebrow (HP:0010747)	3.25283823
10	Abnormality of the renal medulla (HP:0100957)	3.19220825
11	Type II lissencephaly (HP:0007260)	3.08962407
12	Abnormal drinking behavior (HP:0030082)	3.01455194
13	Polydipsia (HP:0001959)	3.01455194
14	Tubular atrophy (HP:0000092)	2.96642236
15	Pendular nystagmus (HP:0012043)	2.87053675
16	Hyperventilation (HP:0002883)	2.83499341
17	Renal cortical cysts (HP:0000803)	2.80544647
18	Gait imbalance (HP:0002141)	2.71546812
19	Congenital primary aphakia (HP:0007707)	2.65130385
20	Cystic liver disease (HP:0006706)	2.63208679
21	Methylmalonic acidemia (HP:0002912)	2.62767390
22	Focal motor seizures (HP:0011153)	2.57972834
23	Abolished electroretinogram (ERG) (HP:0000550)	2.56937153
24	Abnormal rod and cone electroretinograms (HP:0008323)	2.55050195
25	Attenuation of retinal blood vessels (HP:0007843)	2.51058517
26	Chronic hepatic failure (HP:0100626)	2.47244678
27	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.47230972
28	Nephrogenic diabetes insipidus (HP:0009806)	2.42283866
29	Asplenia (HP:0001746)	2.41676645
30	Intestinal atresia (HP:0011100)	2.41465105
31	Cerebellar dysplasia (HP:0007033)	2.36966691
32	Brushfield spots (HP:0001088)	2.36742583
33	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.36675520
34	Hypothermia (HP:0002045)	2.36284644
35	Stomach cancer (HP:0012126)	2.36029985
36	Sclerocornea (HP:0000647)	2.35314573
37	Optic nerve hypoplasia (HP:0000609)	2.29868294
38	Polyuria (HP:0000103)	2.29366036
39	Absent speech (HP:0001344)	2.28928845
40	Keratoconus (HP:0000563)	2.28840199
41	Increased corneal curvature (HP:0100692)	2.28840199
42	Methylmalonic aciduria (HP:0012120)	2.28116790
43	Large for gestational age (HP:0001520)	2.27124494
44	Genital tract atresia (HP:0001827)	2.25278731
45	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.19035253
46	Vaginal atresia (HP:0000148)	2.18149730
47	Progressive inability to walk (HP:0002505)	2.17960929
48	Furrowed tongue (HP:0000221)	2.17496530
49	Increased CSF lactate (HP:0002490)	2.16677784
50	Lissencephaly (HP:0001339)	2.16257900
51	Inability to walk (HP:0002540)	2.16119796
52	Progressive cerebellar ataxia (HP:0002073)	2.15582053
53	Hypomagnesemia (HP:0002917)	2.14496758
54	Gaze-evoked nystagmus (HP:0000640)	2.12941861
55	Abnormality of the labia minora (HP:0012880)	2.12173138
56	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.11939051
57	Hemiparesis (HP:0001269)	2.11038665
58	Febrile seizures (HP:0002373)	2.10366502
59	Bile duct proliferation (HP:0001408)	2.09145914
60	Abnormal biliary tract physiology (HP:0012439)	2.09145914
61	Decreased central vision (HP:0007663)	2.08151928
62	Mitochondrial inheritance (HP:0001427)	2.07107100
63	Anencephaly (HP:0002323)	2.05454844
64	Acute necrotizing encephalopathy (HP:0006965)	2.04121147
65	Broad-based gait (HP:0002136)	2.03265521
66	Congenital hepatic fibrosis (HP:0002612)	2.02861579
67	Fair hair (HP:0002286)	2.01884218
68	Progressive macrocephaly (HP:0004481)	2.01535928
69	Thyroid-stimulating hormone excess (HP:0002925)	2.00129158
70	Severe muscular hypotonia (HP:0006829)	2.00088812
71	Postaxial foot polydactyly (HP:0001830)	1.99743155
72	Focal seizures (HP:0007359)	1.96034348
73	Male pseudohermaphroditism (HP:0000037)	1.91415961
74	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.91122287
75	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.90839241
76	Chorioretinal atrophy (HP:0000533)	1.89939800
77	Tubulointerstitial nephritis (HP:0001970)	1.89128698
78	Lipid accumulation in hepatocytes (HP:0006561)	1.87906325
79	Polyphagia (HP:0002591)	1.87736917
80	Abnormality of macular pigmentation (HP:0008002)	1.87493788
81	Hyperglycinemia (HP:0002154)	1.87165033
82	Decreased circulating renin level (HP:0003351)	1.87053782
83	Pachygyria (HP:0001302)	1.86394078
84	Abnormality of the pons (HP:0007361)	1.84832129
85	Hypoplasia of the pons (HP:0012110)	1.83899251
86	Postaxial hand polydactyly (HP:0001162)	1.83679269
87	Abnormal urine output (HP:0012590)	1.80239592
88	Bony spicule pigmentary retinopathy (HP:0007737)	1.78538502
89	Acute encephalopathy (HP:0006846)	1.77656180
90	Abnormal respiratory epithelium morphology (HP:0012253)	1.77503569
91	Abnormal respiratory motile cilium morphology (HP:0005938)	1.77503569
92	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.76111463
93	Absent/shortened dynein arms (HP:0200106)	1.76111463
94	Specific learning disability (HP:0001328)	1.74742671
95	Increased hepatocellular lipid droplets (HP:0006565)	1.74732397
96	Oligodactyly (hands) (HP:0001180)	1.74509020
97	Abnormality of alanine metabolism (HP:0010916)	1.73121508
98	Hyperalaninemia (HP:0003348)	1.73121508
99	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.73121508
100	Abnormality of vitamin B metabolism (HP:0004340)	1.72236508

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.44757972
2	MAP4K2	3.66306653
3	ADRBK2	3.03409844
4	WNK3	3.02091731
5	BMPR1B	2.94840415
6	CASK	2.78733222
7	ZAK	2.26099444
8	PINK1	2.21714967
9	GRK1	2.18219226
10	WNK4	1.95969493
11	MAP3K4	1.94782198
12	MAPK13	1.94184403
13	NUAK1	1.89695706
14	PASK	1.79952432
15	TAOK3	1.63696845
16	MUSK	1.58972863
17	STK39	1.56652211
18	TLK1	1.52486502
19	OXSR1	1.47501771
20	MARK1	1.44622979
21	MST4	1.42079587
22	PAK3	1.39022979
23	INSRR	1.36587349
24	MAP2K7	1.35824530
25	STK38L	1.28073600
26	PLK2	1.26915728
27	FGFR2	1.21582278
28	TNIK	1.20496276
29	DAPK2	1.18010175
30	ACVR1B	1.17199265
31	DYRK2	1.14951732
32	TRIM28	1.10245288
33	CSNK1G2	1.07733312
34	MKNK2	1.07541874
35	CSNK1G3	1.06434801
36	CSNK1G1	1.06293841
37	TXK	1.05847352
38	PHKG1	1.05290530
39	PHKG2	1.05290530
40	CAMKK2	1.04378225
41	PRKCG	1.04042407
42	EIF2AK3	1.02319260
43	ADRBK1	0.98697362
44	MAP3K12	0.96869686
45	PRKCE	0.96267316
46	ERBB3	0.94185707
47	BCKDK	0.92246214
48	BCR	0.90256761
49	CSNK1A1L	0.89189737
50	NTRK3	0.87190908
51	BRSK2	0.84449335
52	PNCK	0.80310113
53	NTRK2	0.74332198
54	PLK3	0.74136315
55	CAMKK1	0.73513844
56	PTK2B	0.73036870
57	ITK	0.70052241
58	AKT3	0.69075082
59	PKN1	0.68938976
60	VRK1	0.65761111
61	IRAK1	0.62269133
62	MKNK1	0.60826402
63	PRKCQ	0.58284800
64	PRKAA2	0.58223096
65	CSNK1A1	0.56648804
66	PRKCI	0.56542306
67	EPHA3	0.56246274
68	EPHA4	0.54606756
69	CAMK2A	0.50499204
70	PRKACA	0.50330844
71	DYRK3	0.49698911
72	MAP2K4	0.49168753
73	PLK4	0.48832358
74	IKBKB	0.47144166
75	PRKCZ	0.46904205
76	TIE1	0.44933678
77	MAPKAPK3	0.43955019
78	NME1	0.43800340
79	PRKAA1	0.43165199
80	GRK7	0.42838753
81	MAPK15	0.42346052
82	CDK19	0.42171701
83	FER	0.41925340
84	TEC	0.41676323
85	MAP2K6	0.38584292
86	CSNK1D	0.38197071
87	TNK2	0.37942698
88	PLK1	0.35843905
89	CAMK1	0.34302714
90	GRK5	0.34104667
91	TSSK6	0.33430632
92	PRKCA	0.33307835
93	CHUK	0.31984322
94	PRKD3	0.31662416
95	STK11	0.31557122
96	RPS6KA5	0.31522712
97	DYRK1A	0.31504767
98	MAPKAPK5	0.31211419
99	NLK	0.30772870
100	PRKCH	0.30172766

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.90148411
2	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.55153496
3	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.41553844
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.34851279
5	Butanoate metabolism_Homo sapiens_hsa00650	2.34444131
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.34092604
7	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.28701142
8	Nicotine addiction_Homo sapiens_hsa05033	2.28457770
9	Oxidative phosphorylation_Homo sapiens_hsa00190	2.25863203
10	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.20298391
11	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.10857423
12	Protein export_Homo sapiens_hsa03060	2.03585386
13	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.01064716
14	Linoleic acid metabolism_Homo sapiens_hsa00591	2.00443624
15	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.88905277
16	Nitrogen metabolism_Homo sapiens_hsa00910	1.83147989
17	Selenocompound metabolism_Homo sapiens_hsa00450	1.73611566
18	Parkinsons disease_Homo sapiens_hsa05012	1.63613929
19	Fanconi anemia pathway_Homo sapiens_hsa03460	1.58742628
20	Caffeine metabolism_Homo sapiens_hsa00232	1.57883006
21	Tryptophan metabolism_Homo sapiens_hsa00380	1.56272588
22	Peroxisome_Homo sapiens_hsa04146	1.54934537
23	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.54536423
24	Ether lipid metabolism_Homo sapiens_hsa00565	1.52766997
25	Basal transcription factors_Homo sapiens_hsa03022	1.51695605
26	Propanoate metabolism_Homo sapiens_hsa00640	1.45687108
27	RNA polymerase_Homo sapiens_hsa03020	1.43365453
28	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.43069772
29	Morphine addiction_Homo sapiens_hsa05032	1.40109919
30	Regulation of autophagy_Homo sapiens_hsa04140	1.35914020
31	One carbon pool by folate_Homo sapiens_hsa00670	1.32825086
32	Taste transduction_Homo sapiens_hsa04742	1.32179038
33	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.30513401
34	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.23412278
35	GABAergic synapse_Homo sapiens_hsa04727	1.22897153
36	Insulin secretion_Homo sapiens_hsa04911	1.22244865
37	Collecting duct acid secretion_Homo sapiens_hsa04966	1.21511003
38	Homologous recombination_Homo sapiens_hsa03440	1.20748420
39	RNA degradation_Homo sapiens_hsa03018	1.19699801
40	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.12913556
41	Huntingtons disease_Homo sapiens_hsa05016	1.12560755
42	Chemical carcinogenesis_Homo sapiens_hsa05204	1.11540463
43	ABC transporters_Homo sapiens_hsa02010	1.10528838
44	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.10076713
45	Non-homologous end-joining_Homo sapiens_hsa03450	1.10004913
46	Olfactory transduction_Homo sapiens_hsa04740	1.07598722
47	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.06541076
48	Cardiac muscle contraction_Homo sapiens_hsa04260	1.06004526
49	Retinol metabolism_Homo sapiens_hsa00830	1.02683249
50	Alzheimers disease_Homo sapiens_hsa05010	0.99410642
51	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.97044443
52	Serotonergic synapse_Homo sapiens_hsa04726	0.93680483
53	Circadian entrainment_Homo sapiens_hsa04713	0.92481172
54	Circadian rhythm_Homo sapiens_hsa04710	0.88892694
55	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.88859450
56	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.88229377
57	Glycerolipid metabolism_Homo sapiens_hsa00561	0.87983556
58	Salivary secretion_Homo sapiens_hsa04970	0.87671035
59	Glutamatergic synapse_Homo sapiens_hsa04724	0.84248350
60	beta-Alanine metabolism_Homo sapiens_hsa00410	0.84044502
61	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.83127650
62	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.81799161
63	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.80259292
64	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.77811823
65	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.76667378
66	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.75032902
67	Purine metabolism_Homo sapiens_hsa00230	0.68773344
68	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.68313225
69	Metabolic pathways_Homo sapiens_hsa01100	0.68154065
70	Sulfur metabolism_Homo sapiens_hsa00920	0.67646692
71	Steroid biosynthesis_Homo sapiens_hsa00100	0.66086074
72	Fat digestion and absorption_Homo sapiens_hsa04975	0.63601185
73	Dopaminergic synapse_Homo sapiens_hsa04728	0.62014693
74	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.61430462
75	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.60877605
76	Type I diabetes mellitus_Homo sapiens_hsa04940	0.59368703
77	Primary immunodeficiency_Homo sapiens_hsa05340	0.59334688
78	Mineral absorption_Homo sapiens_hsa04978	0.59252625
79	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.59164883
80	Histidine metabolism_Homo sapiens_hsa00340	0.56311958
81	Calcium signaling pathway_Homo sapiens_hsa04020	0.55036261
82	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.54874309
83	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.52570059
84	Proteasome_Homo sapiens_hsa03050	0.52149505
85	Cocaine addiction_Homo sapiens_hsa05030	0.52067461
86	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.49443356
87	Fatty acid degradation_Homo sapiens_hsa00071	0.48874604
88	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.48086932
89	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.46821640
90	Pyrimidine metabolism_Homo sapiens_hsa00240	0.44791876
91	Arginine and proline metabolism_Homo sapiens_hsa00330	0.41803609
92	cAMP signaling pathway_Homo sapiens_hsa04024	0.40937529
93	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.38777311
94	Amphetamine addiction_Homo sapiens_hsa05031	0.38167165
95	Fatty acid metabolism_Homo sapiens_hsa01212	0.37230511
96	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.37026594
97	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.36205199
98	Sphingolipid metabolism_Homo sapiens_hsa00600	0.35480303
99	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.32124655
100	Asthma_Homo sapiens_hsa05310	0.31948513

IARS2P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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