IBSP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tooth mineralization (GO:0034505)8.94666805
2collagen fibril organization (GO:0030199)8.23768287
3endochondral ossification (GO:0001958)7.80296681
4replacement ossification (GO:0036075)7.80296681
5* biomineral tissue development (GO:0031214)7.70434682
6response to vitamin D (GO:0033280)7.44659315
7keratan sulfate biosynthetic process (GO:0018146)7.23650919
8skin morphogenesis (GO:0043589)7.21998643
9bone trabecula formation (GO:0060346)7.19212860
10response to phenylpropanoid (GO:0080184)7.12530935
11chondrocyte development (GO:0002063)6.57584275
12cartilage development involved in endochondral bone morphogenesis (GO:0060351)6.46228527
13bone mineralization (GO:0030282)6.45153511
14keratan sulfate metabolic process (GO:0042339)6.42976192
15collagen catabolic process (GO:0030574)6.42850300
16osteoblast development (GO:0002076)6.41373720
17positive regulation of epidermal cell differentiation (GO:0045606)6.39873971
18collagen metabolic process (GO:0032963)6.23856637
19decidualization (GO:0046697)6.04350064
20multicellular organismal catabolic process (GO:0044243)5.92378182
21negative regulation of biomineral tissue development (GO:0070168)5.88753258
22multicellular organismal macromolecule metabolic process (GO:0044259)5.86960159
23thrombin receptor signaling pathway (GO:0070493)5.78875197
24cellular response to nutrient (GO:0031670)5.71787720
25multicellular organismal metabolic process (GO:0044236)5.53373828
26peptidyl-proline hydroxylation (GO:0019511)5.31803092
27keratan sulfate catabolic process (GO:0042340)5.26549433
28negative regulation of ossification (GO:0030279)5.25557350
29positive regulation of receptor internalization (GO:0002092)5.20508916
30regulation of bone remodeling (GO:0046850)5.05203061
31regulation of bone mineralization (GO:0030500)5.02715958
32regulation of biomineral tissue development (GO:0070167)5.02478749
33negative regulation of bone mineralization (GO:0030502)5.01729043
34regulation of extracellular matrix disassembly (GO:0010715)5.01321714
35chondrocyte proliferation (GO:0035988)4.91849091
36ossification (GO:0001503)4.78727681
37sequestering of extracellular ligand from receptor (GO:0035581)4.77876274
38sulfur compound catabolic process (GO:0044273)4.74174366
39mesenchymal-epithelial cell signaling (GO:0060638)4.73389568
40negative regulation of BMP signaling pathway (GO:0030514)4.65031049
41extracellular matrix disassembly (GO:0022617)4.62210941
42positive regulation of epidermis development (GO:0045684)4.48907899
43protein hydroxylation (GO:0018126)4.37913883
44phosphate ion transmembrane transport (GO:0035435)4.36264074
45glycosaminoglycan catabolic process (GO:0006027)4.31233947
46regulation of alkaline phosphatase activity (GO:0010692)4.30804340
47negative regulation of establishment of protein localization to plasma membrane (GO:0090005)4.25836719
48Golgi transport vesicle coating (GO:0048200)4.21651102
49COPI coating of Golgi vesicle (GO:0048205)4.21651102
50skeletal system development (GO:0001501)4.10444369
51bone development (GO:0060348)4.04545076
52positive regulation of inositol phosphate biosynthetic process (GO:0060732)4.03915367
53aminoglycan catabolic process (GO:0006026)3.98984624
54endodermal cell differentiation (GO:0035987)3.97996451
55* osteoblast differentiation (GO:0001649)3.94044775
56bone morphogenesis (GO:0060349)3.92450726
57import into cell (GO:0098657)3.91774870
58neuron projection extension involved in neuron projection guidance (GO:1902284)3.89942681
59axon extension involved in axon guidance (GO:0048846)3.89942681
60positive regulation of collagen biosynthetic process (GO:0032967)3.86373038
61embryonic viscerocranium morphogenesis (GO:0048703)3.85277470
62regulation of G0 to G1 transition (GO:0070316)3.79431763
63negative regulation of protein localization to plasma membrane (GO:1903077)3.76692990
64positive regulation of collagen metabolic process (GO:0010714)3.69651350
65cartilage development (GO:0051216)3.68326254
66phosphate ion transport (GO:0006817)3.64826863
67substrate-dependent cell migration (GO:0006929)3.54839240
68maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.53393640
69regulation of receptor internalization (GO:0002090)3.53025171
70* extracellular matrix organization (GO:0030198)3.50526529
71protein trimerization (GO:0070206)3.49229744
72positive regulation of osteoblast proliferation (GO:0033690)3.49221252
73* extracellular structure organization (GO:0043062)3.49148347
74response to testosterone (GO:0033574)3.46017635
75regulation of tissue remodeling (GO:0034103)3.41187771
76cellular response to amino acid stimulus (GO:0071230)3.38128208
77regulation of bone resorption (GO:0045124)3.37365118
78iron ion import (GO:0097286)3.35171470
79lymphangiogenesis (GO:0001946)3.34943513
80peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.34776463
81positive regulation of Rho protein signal transduction (GO:0035025)3.32352136
82virion attachment to host cell (GO:0019062)3.31250992
83adhesion of symbiont to host cell (GO:0044650)3.31250992
84extracellular matrix assembly (GO:0085029)3.30819279
85regulation of collagen biosynthetic process (GO:0032965)3.26243518
86protein retention in ER lumen (GO:0006621)3.25914296
87positive regulation of extracellular matrix organization (GO:1903055)3.25555626
88anterior/posterior axis specification, embryo (GO:0008595)3.24173083
89regulation of inositol phosphate biosynthetic process (GO:0010919)3.24021667
90regulation of BMP signaling pathway (GO:0030510)3.21009916
91glomerular filtration (GO:0003094)3.19680491
92planar cell polarity pathway involved in neural tube closure (GO:0090179)3.16894725
93positive regulation of cell-substrate adhesion (GO:0010811)3.16641624
94pathway-restricted SMAD protein phosphorylation (GO:0060389)3.15647488
95positive regulation of catenin import into nucleus (GO:0035413)3.09351346
96vascular endothelial growth factor signaling pathway (GO:0038084)3.08633061
97response to parathyroid hormone (GO:0071107)3.08158410
98tissue remodeling (GO:0048771)3.07654632
99glycosaminoglycan biosynthetic process (GO:0006024)3.06302616
100peptidyl-glutamic acid carboxylation (GO:0017187)3.04458252
101protein carboxylation (GO:0018214)3.04458252
102glomerular basement membrane development (GO:0032836)3.03553566
103aminoglycan biosynthetic process (GO:0006023)3.02171480
104vasculature development (GO:0001944)3.01874110
105dermatan sulfate biosynthetic process (GO:0030208)3.00425413
106negative regulation of canonical Wnt signaling pathway (GO:0090090)2.99083145
107regulation of collagen metabolic process (GO:0010712)2.99005527
108adhesion of symbiont to host (GO:0044406)2.98829047
109extracellular regulation of signal transduction (GO:1900115)2.95422292
110extracellular negative regulation of signal transduction (GO:1900116)2.95422292
111chondroitin sulfate biosynthetic process (GO:0030206)2.94969458
112cartilage condensation (GO:0001502)2.94320673
113cell aggregation (GO:0098743)2.94320673
114phagocytosis, recognition (GO:0006910)2.94179754
1154-hydroxyproline metabolic process (GO:0019471)2.93928572
116regulation of epidermal cell differentiation (GO:0045604)2.93249613
117vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.92364932
118craniofacial suture morphogenesis (GO:0097094)2.91396077
119regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.90286660
120COPII vesicle coating (GO:0048208)2.85872523
121hematopoietic stem cell differentiation (GO:0060218)2.84510774
122regulation of tight junction assembly (GO:2000810)2.83897531
123negative regulation of glycogen biosynthetic process (GO:0045719)2.81853777
124renal filtration (GO:0097205)2.81075472
125anion homeostasis (GO:0055081)2.80198874
126positive regulation of cardiac muscle cell differentiation (GO:2000727)2.79783688
127negative regulation of JNK cascade (GO:0046329)2.79461256
128positive regulation of multicellular organismal metabolic process (GO:0044253)2.78650619
129regulation of extracellular matrix organization (GO:1903053)2.77779382
130cell adhesion mediated by integrin (GO:0033627)2.77219438
131germ cell migration (GO:0008354)2.76832027
132positive regulation of receptor-mediated endocytosis (GO:0048260)2.75838623
133platelet dense granule organization (GO:0060155)2.72800637
134chondrocyte differentiation (GO:0002062)2.72292468
135negative regulation of embryonic development (GO:0045992)2.72075002
136dermatan sulfate metabolic process (GO:0030205)2.68912172
137positive regulation of stem cell differentiation (GO:2000738)2.68878940
138positive regulation of epithelial to mesenchymal transition (GO:0010718)2.67907241
139secondary heart field specification (GO:0003139)2.67440447
140heart field specification (GO:0003128)2.67440447
141C4-dicarboxylate transport (GO:0015740)2.66925945
142regulation of ossification (GO:0030278)2.65965873
143bone resorption (GO:0045453)2.64983273
144positive regulation of mesenchymal cell proliferation (GO:0002053)2.64290243
145face morphogenesis (GO:0060325)2.63712219
146negative regulation of chondrocyte differentiation (GO:0032331)2.63368012
147apoptotic cell clearance (GO:0043277)2.62607879
148response to zinc ion (GO:0010043)2.61576292
149regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.61475633
150positive regulation of cartilage development (GO:0061036)2.60581352
151embryonic skeletal joint morphogenesis (GO:0060272)2.59485827
152response to vitamin (GO:0033273)2.59095925
153cell migration involved in heart development (GO:0060973)2.55878739
154trabecula formation (GO:0060343)2.55868280
155cellular response to vitamin D (GO:0071305)13.5601252
156cellular response to vitamin (GO:0071295)11.2555555
157phosphate ion homeostasis (GO:0055062)10.9122771
158trivalent inorganic anion homeostasis (GO:0072506)10.9122771
159response to gravity (GO:0009629)10.8450104
160protein heterotrimerization (GO:0070208)10.0668815

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human7.08473658
2ZNF652_21678463_ChIP-ChIP_ZR75-1_Human4.33930998
3WT1_19549856_ChIP-ChIP_CCG9911_Human4.09983076
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.82177861
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.57376322
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.57318213
7RUNX2_24764292_ChIP-Seq_MC3T3_Mouse3.03215690
8CLOCK_20551151_ChIP-Seq_293T_Human2.69132815
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.44711475
10ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.43623419
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.35979678
12TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.29601559
13CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.27474243
14ESR1_21235772_ChIP-Seq_MCF-7_Human2.25345255
15RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.15420447
16VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.10079425
17CJUN_26792858_Chip-Seq_BT549_Human2.09112370
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.05003307
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.98680585
20CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.97780899
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.95538327
22EZH2_27294783_Chip-Seq_NPCs_Mouse1.92690102
23EED_16625203_ChIP-ChIP_MESCs_Mouse1.92087165
24KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.87380562
25KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.87380562
26KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.87380562
27WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.86751901
28NRF2_20460467_ChIP-Seq_MEFs_Mouse1.80121347
29NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.80121347
30EZH2_18974828_ChIP-Seq_MESCs_Mouse1.79621083
31RNF2_18974828_ChIP-Seq_MESCs_Mouse1.79621083
32SUZ12_27294783_Chip-Seq_NPCs_Mouse1.75223817
33HIF1A_21447827_ChIP-Seq_MCF-7_Human1.69164275
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.68569298
35SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.66330692
36SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.62072874
37NFE2_27457419_Chip-Seq_LIVER_Mouse1.57517982
38BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.56104920
39SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.55861814
40PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.54577372
41EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.53421104
42P300_27058665_Chip-Seq_ZR-75-30cells_Human1.53036342
43RBPJ_22232070_ChIP-Seq_NCS_Mouse1.52338357
44CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.48852862
45TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.48185561
46CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.47942862
47PCGF2_27294783_Chip-Seq_NPCs_Mouse1.47059392
48CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.47054445
49BRD4_25478319_ChIP-Seq_HGPS_Human1.45955358
50HNFA_21074721_ChIP-Seq_CACO-2_Human1.44089543
51EZH2_27304074_Chip-Seq_ESCs_Mouse1.43457845
52ETV1_20927104_ChIP-Seq_GIST48_Human1.43240728
53TP53_20018659_ChIP-ChIP_R1E_Mouse1.42302622
54NANOG_18555785_Chip-Seq_ESCs_Mouse1.41113383
55JARID2_20075857_ChIP-Seq_MESCs_Mouse1.40926183
56P53_22387025_ChIP-Seq_ESCs_Mouse1.40710065
57JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.40592932
58NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.40457334
59EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.38523082
60CBX2_22325352_ChIP-Seq_293T-Rex_Human1.35484340
61EP300_21415370_ChIP-Seq_HL-1_Mouse1.35141196
62GATA1_22025678_ChIP-Seq_K562_Human1.35134962
63PHF8_20622853_ChIP-Seq_HELA_Human1.34634411
64TP53_18474530_ChIP-ChIP_U2OS_Human1.33874636
65SMC1_22415368_ChIP-Seq_MEFs_Mouse1.32062630
66EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.31770296
67RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31624888
68PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.31499349
69NFYB_21822215_ChIP-Seq_K562_Human1.31178378
70TBL1_22424771_ChIP-Seq_293T_Human1.30826354
71E2F1_18555785_Chip-Seq_ESCs_Mouse1.30683785
72PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30677125
73ZFP57_27257070_Chip-Seq_ESCs_Mouse1.30315498
74RNF2_27304074_Chip-Seq_ESCs_Mouse1.28694315
75PU1_27457419_Chip-Seq_LIVER_Mouse1.27819341
76GATA6_21074721_ChIP-Seq_CACO-2_Human1.27499261
77FOXM1_26456572_ChIP-Seq_MCF-7_Human1.27466789
78GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.27063406
79FOXO3_23340844_ChIP-Seq_DLD1_Human1.26073774
80DROSHA_22980978_ChIP-Seq_HELA_Human1.25875483
81RBPJ_21746931_ChIP-Seq_IB4_Human1.25705826
82* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25610513
83FLI1_27457419_Chip-Seq_LIVER_Mouse1.24814799
84CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.24660755
85Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.22837097
86MTF2_20144788_ChIP-Seq_MESCs_Mouse1.22787636
87PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21537959
88PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21203503
89RUNX1_27457419_Chip-Seq_LIVER_Mouse1.20238636
90SUZ12_18555785_Chip-Seq_ESCs_Mouse1.19567040
91SMAD4_21799915_ChIP-Seq_A2780_Human1.19564354
92TBX20_22080862_ChIP-Seq_HEART_Mouse1.18907655
93TBX20_22328084_ChIP-Seq_HEART_Mouse1.18907655
94NFYA_21822215_ChIP-Seq_K562_Human1.18392267
95AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17827105
96TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.17169311
97* P300_19829295_ChIP-Seq_ESCs_Human1.16934270
98JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16233801
99JARID2_20064375_ChIP-Seq_MESCs_Mouse1.15025232
100CMYC_18555785_Chip-Seq_ESCs_Mouse1.14683199
101ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14495778
102SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.14272333
103KDM2B_26808549_Chip-Seq_K562_Human1.13400348
104SALL4_18804426_ChIP-ChIP_XEN_Mouse1.10920230
105STAT3_18555785_Chip-Seq_ESCs_Mouse1.10541120
106TP63_23658742_ChIP-Seq_EP156T_Human1.09815347
107SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09758549
108ZFP281_18757296_ChIP-ChIP_E14_Mouse1.09719139
109SOX2_20726797_ChIP-Seq_SW620_Human1.09705057
110UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.09528953
111SA1_22415368_ChIP-Seq_MEFs_Mouse1.08871096
112ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.07581897
113ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07503085
114PPAR_26484153_Chip-Seq_NCI-H1993_Human1.07042708
115GATA2_21666600_ChIP-Seq_HMVEC_Human1.06378188
116SOX2_18555785_Chip-Seq_ESCs_Mouse1.06300108
117SMC3_22415368_ChIP-Seq_MEFs_Mouse1.06208390
118PIAS1_25552417_ChIP-Seq_VCAP_Human1.05594510
119IRF8_27001747_Chip-Seq_BMDM_Mouse1.05429547
120STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.05244141
121NMYC_18555785_Chip-Seq_ESCs_Mouse1.05091141
122OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04590733
123SMAD_19615063_ChIP-ChIP_OVARY_Human1.04482273
124ERG_21242973_ChIP-ChIP_JURKAT_Human1.03158975
125TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.03098206
126CRX_20693478_ChIP-Seq_RETINA_Mouse1.02890481
127* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02881606
128RUNX_20019798_ChIP-Seq_JUKART_Human1.02812605
129TAL1_26923725_Chip-Seq_HPCs_Mouse1.02029173
130OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00999160
131SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.00801066
132ISL1_27105846_Chip-Seq_CPCs_Mouse0.98705489
133SUZ12_27294783_Chip-Seq_ESCs_Mouse0.97854934
134EZH2_27294783_Chip-Seq_ESCs_Mouse0.96710908
135TP53_22127205_ChIP-Seq_IMR90_Human0.96080907
136RING1B_27294783_Chip-Seq_NPCs_Mouse0.95960247
137ESR1_20079471_ChIP-ChIP_T-47D_Human0.95739889
138NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.95535479
139RING1B_27294783_Chip-Seq_ESCs_Mouse0.95326384
140SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95247469
141NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95117091
142TCF4_18268006_ChIP-ChIP_LS174T_Human0.93140359
143RXR_22108803_ChIP-Seq_LS180_Human0.91972294
144CDX2_19796622_ChIP-Seq_MESCs_Mouse0.91259657
145PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.90373955
146THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.87258492
147NR3C1_23031785_ChIP-Seq_PC12_Mouse0.83766255
148TP53_16413492_ChIP-PET_HCT116_Human0.82693896
149ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.79726243
150SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.79616747
151ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78688135
152SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.76452737
153WT1_25993318_ChIP-Seq_PODOCYTE_Human0.76276222
154TP53_23651856_ChIP-Seq_MEFs_Mouse0.76186304
155TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.76092886
156NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.75526894
157SOX2_21211035_ChIP-Seq_LN229_Gbm0.75474856

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001542_abnormal_bone_strength8.96312673
2MP0004185_abnormal_adipocyte_glucose7.29987503
3MP0008438_abnormal_cutaneous_collagen6.33545280
4MP0005503_abnormal_tendon_morphology4.89357572
5MP0005275_abnormal_skin_tensile4.04346884
6MP0005083_abnormal_biliary_tract3.98921900
7* MP0002896_abnormal_bone_mineralization3.35660544
8MP0006054_spinal_hemorrhage3.34928972
9* MP0002998_abnormal_bone_remodeling3.28577633
10MP0005666_abnormal_adipose_tissue3.09386020
11MP0003279_aneurysm2.83558486
12MP0005257_abnormal_intraocular_pressure2.63871682
13MP0009250_abnormal_appendicular_skeleto2.39475430
14* MP0002115_abnormal_skeleton_extremities2.38368536
15MP0004272_abnormal_basement_membrane2.19936137
16MP0010368_abnormal_lymphatic_system2.15056122
17MP0004134_abnormal_chest_morphology2.13168921
18MP0000163_abnormal_cartilage_morphology2.12282020
19MP0005375_adipose_tissue_phenotype2.07433537
20MP0009384_cardiac_valve_regurgitation1.99315627
21* MP0003795_abnormal_bone_structure1.97011751
22MP0002113_abnormal_skeleton_development1.96557193
23MP0005508_abnormal_skeleton_morphology1.95400455
24MP0003283_abnormal_digestive_organ1.86535834
25MP0002108_abnormal_muscle_morphology1.85354138
26MP0002295_abnormal_pulmonary_circulatio1.84955590
27MP0005084_abnormal_gallbladder_morpholo1.81982347
28MP0000751_myopathy1.80351872
29MP0004019_abnormal_vitamin_homeostasis1.66944128
30MP0003705_abnormal_hypodermis_morpholog1.66072845
31MP0000569_abnormal_digit_pigmentation1.64966434
32MP0000013_abnormal_adipose_tissue1.64373750
33MP0001958_emphysema1.60899811
34* MP0005390_skeleton_phenotype1.59819165
35* MP0001533_abnormal_skeleton_physiology1.56909616
36MP0001299_abnormal_eye_distance/1.50104137
37MP0003718_maternal_effect1.49513678
38MP0005023_abnormal_wound_healing1.47814884
39* MP0002109_abnormal_limb_morphology1.32889428
40MP0009780_abnormal_chondrocyte_physiolo1.31342026
41MP0002089_abnormal_postnatal_growth/wei1.30561363
42MP0002282_abnormal_trachea_morphology1.30275963
43MP0002060_abnormal_skin_morphology1.29029905
44MP0005365_abnormal_bile_salt1.25154446
45MP0003566_abnormal_cell_adhesion1.24489286
46MP0001664_abnormal_digestion1.23614132
47MP0005623_abnormal_meninges_morphology1.23250395
48MP0000462_abnormal_digestive_system1.18459176
49MP0001243_abnormal_dermal_layer1.17584578
50MP0002233_abnormal_nose_morphology1.17374481
51MP0003183_abnormal_peptide_metabolism1.16051758
52MP0002933_joint_inflammation1.15077613
53MP0001879_abnormal_lymphatic_vessel1.14408868
54MP0009115_abnormal_fat_cell1.11735745
55MP0005395_other_phenotype1.07647584
56MP0000604_amyloidosis1.04302027
57MP0002116_abnormal_craniofacial_bone1.03188223
58MP0000432_abnormal_head_morphology1.01259982
59MP0000762_abnormal_tongue_morphology1.01175992
60MP0005164_abnormal_response_to0.94020928
61MP0003935_abnormal_craniofacial_develop0.92837267
62MP0005085_abnormal_gallbladder_physiolo0.91301313
63MP0002419_abnormal_innate_immunity0.90404035
64MP0010030_abnormal_orbit_morphology0.88100090
65MP0001765_abnormal_ion_homeostasis0.87142821
66MP0001666_abnormal_nutrient_absorption0.83144848
67MP0003385_abnormal_body_wall0.82931210
68MP0010386_abnormal_urinary_bladder0.82415341
69MP0002932_abnormal_joint_morphology0.76960905
70MP0001915_intracranial_hemorrhage0.75472297
71MP0004510_myositis0.75178747
72MP0005448_abnormal_energy_balance0.74032199
73MP0001944_abnormal_pancreas_morphology0.73231002
74MP0001849_ear_inflammation0.71874862
75MP0000428_abnormal_craniofacial_morphol0.68333745
76MP0000003_abnormal_adipose_tissue0.68101481
77MP0003755_abnormal_palate_morphology0.67308454
78MP0009278_abnormal_bone_marrow0.65220871
79MP0002111_abnormal_tail_morphology0.63044293
80MP0000049_abnormal_middle_ear0.63011304
81MP0003646_muscle_fatigue0.57151106
82MP0002114_abnormal_axial_skeleton0.56708885
83MP0005636_abnormal_mineral_homeostasis0.56590827
84MP0003091_abnormal_cell_migration0.56504987
85MP0002909_abnormal_adrenal_gland0.56441952
86MP0000681_abnormal_thyroid_gland0.55887340
87MP0000767_abnormal_smooth_muscle0.55865007
88MP0003937_abnormal_limbs/digits/tail_de0.55091328
89MP0001270_distended_abdomen0.53557590
90MP0004858_abnormal_nervous_system0.50736652
91MP0005076_abnormal_cell_differentiation0.48682844
92MP0003868_abnormal_feces_composition0.48610315
93MP0000733_abnormal_muscle_development0.45695469
94MP0003959_abnormal_lean_body0.45174294
95MP0003300_gastrointestinal_ulcer0.45080428
96MP0002877_abnormal_melanocyte_morpholog0.44230326
97MP0000465_gastrointestinal_hemorrhage0.43861997
98MP0005248_abnormal_Harderian_gland0.43448605
99MP0005595_abnormal_vascular_smooth0.42865309
100MP0003942_abnormal_urinary_system0.42832843
101MP0010234_abnormal_vibrissa_follicle0.41968975
102MP0005621_abnormal_cell_physiology0.41245703
103MP0002163_abnormal_gland_morphology0.40900213
104MP0005165_increased_susceptibility_to0.40493811
105MP0004883_abnormal_blood_vessel0.40297439
106MP0000537_abnormal_urethra_morphology0.40170847
107MP0002128_abnormal_blood_circulation0.40039497
108MP0003195_calcinosis0.39082678
109MP0002249_abnormal_larynx_morphology0.38631830
110MP0002177_abnormal_outer_ear0.38343356
111MP0002168_other_aberrant_phenotype0.38243907
112MP0005369_muscle_phenotype0.38109876
113MP0002452_abnormal_antigen_presenting0.36576530
114MP0003115_abnormal_respiratory_system0.36514073
115MP0003122_maternal_imprinting0.36502340
116MP0004084_abnormal_cardiac_muscle0.36022766
117MP0001731_abnormal_postnatal_growth0.34447243
118MP0004859_abnormal_synaptic_plasticity0.33784398
119MP0001346_abnormal_lacrimal_gland0.33554813
120MP0000026_abnormal_inner_ear0.33549989
121MP0004036_abnormal_muscle_relaxation0.33461287
122MP0003941_abnormal_skin_development0.33125381
123MP0003172_abnormal_lysosome_physiology0.33040712
124MP0003045_fibrosis0.32108332
125MP0001614_abnormal_blood_vessel0.32097169
126MP0005187_abnormal_penis_morphology0.31833594
127MP0010352_gastrointestinal_tract_polyps0.31444966
128MP0000358_abnormal_cell_content/0.31084458
129MP0000343_altered_response_to0.31018755
130MP0004808_abnormal_hematopoietic_stem0.30705230
131MP0001177_atelectasis0.30244431
132MP0005464_abnormal_platelet_physiology0.30203801
133MP0000534_abnormal_ureter_morphology0.28642635
134MP0005451_abnormal_body_composition0.28061336
135MP0000566_synostosis0.28053514
136MP0005220_abnormal_exocrine_pancreas0.27831737
137MP0005193_abnormal_anterior_eye0.27823293
138MP0008775_abnormal_heart_ventricle0.27381307
139MP0005388_respiratory_system_phenotype0.26896453
140MP0002133_abnormal_respiratory_system0.26896453

Predicted human phenotypes

RankGene SetZ-score
1Metaphyseal cupping (HP:0003021)8.20932883
2Protrusio acetabuli (HP:0003179)7.38993306
3Small epiphyses (HP:0010585)6.81290721
4Premature rupture of membranes (HP:0001788)6.52119353
5Facial diplegia (HP:0001349)5.86204457
6Overgrowth (HP:0001548)5.44580965
7Neonatal short-limb short stature (HP:0008921)5.17097696
8Enlarged epiphyses (HP:0010580)5.13489888
9Cupped ribs (HP:0000887)5.09272264
10Biconcave vertebral bodies (HP:0004586)4.95710531
11Ulnar bowing (HP:0003031)4.79203293
12Choanal stenosis (HP:0000452)4.75598236
13Abnormality of dentin (HP:0010299)4.74332266
14Hypophosphatemic rickets (HP:0004912)4.46823554
15Mild short stature (HP:0003502)4.28242002
16Peritonitis (HP:0002586)4.28035363
17Wormian bones (HP:0002645)4.19849158
18Epiphyseal dysplasia (HP:0002656)4.09076743
19Flattened epiphyses (HP:0003071)4.05774657
20Femoral bowing (HP:0002980)4.04562560
21Osteoarthritis (HP:0002758)3.99641479
22Tibial bowing (HP:0002982)3.95600777
23Hypophosphatemia (HP:0002148)3.93242666
24Atrophic scars (HP:0001075)3.89943434
25Soft skin (HP:0000977)3.88224510
26Sudden death (HP:0001699)3.81114367
27Irregular vertebral endplates (HP:0003301)3.73608555
28Abnormality of the vertebral endplates (HP:0005106)3.71137535
29Hypoplastic ischia (HP:0003175)3.68443228
30Aortic dissection (HP:0002647)3.57027749
31Spondylolisthesis (HP:0003302)3.53673832
32Abnormality of the ischium (HP:0003174)3.48665878
33Radial bowing (HP:0002986)3.47989504
34Genu recurvatum (HP:0002816)3.46608143
35Platyspondyly (HP:0000926)3.44457917
36Coxa vara (HP:0002812)3.32816719
37Papilledema (HP:0001085)3.30785464
38Elevated alkaline phosphatase (HP:0003155)3.29804987
39Ankle contracture (HP:0006466)3.29059799
40Blue sclerae (HP:0000592)3.28595810
41Delayed epiphyseal ossification (HP:0002663)3.27836649
42Flared metaphyses (HP:0003015)3.26740096
43Genu varum (HP:0002970)3.19790547
44Broad metatarsal (HP:0001783)3.13159278
45Follicular hyperkeratosis (HP:0007502)3.11943878
46Bowed forearm bones (HP:0003956)3.09828407
47Bowing of the arm (HP:0006488)3.09828407
48Osteomalacia (HP:0002749)3.07127065
49Bladder diverticulum (HP:0000015)3.01551351
50Breech presentation (HP:0001623)2.99732157
51Abnormal tarsal ossification (HP:0008369)2.98931173
52Irregular epiphyses (HP:0010582)2.98084503
53Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.97819119
54Decreased skull ossification (HP:0004331)2.97524122
55Abnormality of alkaline phosphatase activity (HP:0004379)2.96514012
56Cervical subluxation (HP:0003308)2.95185198
57Vertebral clefting (HP:0008428)2.92609695
58Nonimmune hydrops fetalis (HP:0001790)2.92458773
59Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.91960374
60Metaphyseal dysplasia (HP:0100255)2.88345845
61Abnormal enzyme/coenzyme activity (HP:0012379)2.86795511
62Flared iliac wings (HP:0002869)2.82991019
63Rickets (HP:0002748)2.82434638
64Arthropathy (HP:0003040)2.81584311
65Constricted visual fields (HP:0001133)2.81159134
66Vertebral compression fractures (HP:0002953)2.80826414
67Abnormality of the frontal sinuses (HP:0002687)2.77800986
68Infantile muscular hypotonia (HP:0008947)2.72666421
69Spinal cord compression (HP:0002176)2.72040167
70Metaphyseal irregularity (HP:0003025)2.71060077
71Fragile skin (HP:0001030)2.67461398
72Limited elbow extension (HP:0001377)2.66550753
73Abnormality of Sharpey fibers (HP:0100685)2.62575678
74Abnormality of skull ossification (HP:0002703)2.62201196
75Broad ribs (HP:0000885)2.61520773
76Short middle phalanx of finger (HP:0005819)2.53996893
77Abnormality of the costochondral junction (HP:0000919)2.51449643
78Rhizomelia (HP:0008905)2.51081393
79Shallow orbits (HP:0000586)2.50218036
80Morphological abnormality of the middle ear (HP:0008609)2.48631055
81Abnormal vertebral ossification (HP:0100569)2.48181727
82Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.47806453
83Bell-shaped thorax (HP:0001591)2.45462403
84Mitral valve prolapse (HP:0001634)2.41735990
85Persistence of primary teeth (HP:0006335)2.41283776
86Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.39672089
87Craniofacial hyperostosis (HP:0004493)2.38448651
88Abnormal delivery (HP:0001787)2.38359917
89Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.36513692
90Abnormality of femoral epiphyses (HP:0006499)2.36513692
91Abnormality of the epiphysis of the femoral head (HP:0010574)2.35705729
92Abnormal foot bone ossification (HP:0010675)2.34888715
93Abnormality of the acetabulum (HP:0003170)2.34568276
94Waddling gait (HP:0002515)2.32080322
95Hyperextensible skin (HP:0000974)2.29857828
96Vitreoretinal degeneration (HP:0000655)2.27215748
97Abnormality of the femoral head (HP:0003368)2.19265307
98Wide anterior fontanel (HP:0000260)2.14094372
99Type 1 muscle fiber predominance (HP:0003803)2.13046894
100Slender build (HP:0001533)2.07691082
101Widely patent fontanelles and sutures (HP:0004492)2.06784155
102Progressive visual loss (HP:0000529)2.06709498
103Limited hip movement (HP:0008800)2.05451699
104Wide cranial sutures (HP:0010537)2.03745772
105Hip contracture (HP:0003273)2.03196692
106Osteolytic defects of the hand bones (HP:0009699)2.02295959
107Osteolytic defects of the phalanges of the hand (HP:0009771)2.02295959
108Stillbirth (HP:0003826)2.02114868
109Bowel diverticulosis (HP:0005222)2.01499430
110Absent frontal sinuses (HP:0002688)2.01060404
111Cranial hyperostosis (HP:0004437)2.01046368
112Arterial tortuosity (HP:0005116)2.00918898
113Abnormality of carpal bone ossification (HP:0006257)2.00721584
114Broad long bones (HP:0005622)1.98306755
115Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.97433215
116Abnormality of the peritoneum (HP:0002585)1.95214941
117Short ribs (HP:0000773)1.94386095
118Dilatation of the ascending aorta (HP:0005111)1.94348965
119Increased density of long bones (HP:0006392)1.93227823
120Deviation of the hallux (HP:0010051)1.91575901
121Joint laxity (HP:0001388)1.90842318
122Bone pain (HP:0002653)1.90053608
123Abnormality of calcium-phosphate metabolism (HP:0100530)1.89616183
124Hallux valgus (HP:0001822)1.89064035
125Ectopia lentis (HP:0001083)1.88226106
126Osteopenia (HP:0000938)1.87668319
127Hypercalcemia (HP:0003072)1.85797970
128Beaking of vertebral bodies (HP:0004568)1.85471161
129Flat capital femoral epiphysis (HP:0003370)1.85389959
130Abnormal cortical bone morphology (HP:0003103)1.79005389
131Vascular tortuosity (HP:0004948)1.77133175
132Abnormality of the middle phalanges of the hand (HP:0009833)1.71969857
133Spinal canal stenosis (HP:0003416)1.71002508
134Esotropia (HP:0000565)1.69922340
135Mixed hearing impairment (HP:0000410)1.61079083
136Broad phalanx (HP:0006009)1.54517255
137Abnormal urine phosphate concentration (HP:0012599)1.51205734
138Broad phalanges of the hand (HP:0009768)1.47596297
139Abnormal cartilage morphology (HP:0002763)1.46717246
140Abnormality of primary teeth (HP:0006481)1.46625981
141Aortic aneurysm (HP:0004942)1.43826613
142Carpal bone hypoplasia (HP:0001498)1.42319416
143Midface retrusion (HP:0011800)1.40148750
144Broad finger (HP:0001500)1.39511003
145Chondrocalcinosis (HP:0000934)1.35689106
146Delayed closure of the anterior fontanelle (HP:0001476)1.35171433
147Cardiovascular calcification (HP:0011915)1.33834470
148Increased intracranial pressure (HP:0002516)1.29630096
149Abnormality of intracranial pressure (HP:0012640)1.29630096
150Vascular calcification (HP:0004934)1.27775552
151Spontaneous hematomas (HP:0007420)1.14379771
152Syringomyelia (HP:0003396)1.11587820
153Spinal cord lesions (HP:0100561)1.11587820
154Short distal phalanx of finger (HP:0009882)1.11391432
155Atresia of the external auditory canal (HP:0000413)1.09008080
156Hypoplasia of the odontoid process (HP:0003311)1.08337587
157Prominent supraorbital ridges (HP:0000336)1.06880464
158J-shaped sella turcica (HP:0002680)1.05065764
159Abnormality of the intervertebral disk (HP:0005108)1.04364170

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA34.37613710
2SIK14.02523482
3PDGFRA3.56241707
4MST1R3.13897511
5NTRK22.95243129
6PKN22.79371252
7BLK2.68873017
8TRIB32.59599361
9MAP3K132.57334868
10TNIK2.55335803
11FGFR22.48091027
12PNCK2.47964762
13CCNB12.26291333
14NLK2.18623749
15DDR210.9408803
16FLT31.83968779
17MAP3K61.77090183
18TTN1.75578332
19RIPK11.64675421
20FRK1.61091538
21FGFR11.56726066
22MYLK1.54468732
23EPHB21.48748913
24MOS1.36560596
25NTRK11.35328403
26LATS11.34522286
27PDGFRB1.27293484
28ARAF1.24526096
29FER1.22850338
30KIT1.22657422
31MST41.16984942
32CSF1R1.14838651
33PLK21.14423824
34MET1.14165383
35SGK21.13137556
36LATS21.12280608
37STK241.10465214
38PIK3CA1.08742198
39ERN11.08452791
40MAP3K141.08275211
41PAK21.05800206
42ROCK10.99505619
43WNK10.98564236
44NTRK30.98399145
45TIE10.97104429
46TGFBR20.96817237
47FGFR30.95392627
48PDK20.94014060
49AKT30.93740173
50PTK60.92652670
51JAK10.92192375
52PRKG20.92018103
53BMX0.91491774
54MUSK0.89765757
55MAPK120.87609196
56MAPK70.84316324
57PAK30.82464999
58MAP3K90.81941060
59PAK40.81029940
60LRRK20.79287390
61TRPM70.76209324
62PIM20.75445665
63ERBB40.74813094
64RET0.73931340
65STK380.73027728
66STK30.72875842
67CDK80.72140317
68ADRBK10.70734906
69ZAP700.68840351
70CAMKK20.67384311
71CSK0.64392543
72DYRK1B0.63256557
73SGK2230.62183981
74SGK4940.62183981
75ROCK20.61757737
76PRKG10.59258304
77MAP3K40.59111016
78SIK30.57170835
79TEC0.56935034
80SCYL20.56263481
81CDK60.56080948
82CAMKK10.54799335
83NME20.53321642
84EEF2K0.52854162
85IGF1R0.52632312
86MAP3K20.51899867
87ABL20.51726678
88PTK20.50350974
89SGK30.50160962
90INSR0.49227934
91EPHA20.48228267
92PRKCE0.48161539
93DAPK30.47775906
94CASK0.46171252
95MAPK100.45665868
96EPHB10.44357951
97CSNK1G10.42888759
98ILK0.41889936
99ABL10.41887041
100PKN10.40558283
101FGFR40.40383158
102EIF2AK20.38871268
103PRKCQ0.38728681
104PRKCG0.38212372
105CDC42BPA0.37381043
106STK38L0.37027806
107NEK90.36983114
108MAP2K10.36257498
109PTK2B0.35112038
110GSK3A0.34204488
111PDPK10.33711886
112MAPKAPK50.33284764
113TESK10.32974299
114SRC0.32079948
115STK390.31822168
116PRKCH0.31494393
117TGFBR10.31156508
118FYN0.31121349
119PAK60.30815225
120SYK0.30798563
121DMPK0.30755261
122MTOR0.30379645
123PRKD10.30145861
124MAP3K100.29967682
125EIF2AK30.29471505
126PBK0.29348372
127TYRO30.28914503
128DAPK20.28862767
129MAPK30.28347573
130CAMK1D0.26399981
131PIK3CG0.26290853
132TBK10.25278813
133CAMK1G0.25148920
134GRK70.24179043
135JAK30.23423833
136MAPK140.22511536
137CSNK1A1L0.22340446
138STK100.21498182
139SGK10.21228199
140KSR10.20388303
141MAPK40.19898187
142ERBB30.19813341
143KSR20.19480920
144LMTK20.18429850
145HCK0.17837051
146TAF10.17558125
147TYK20.16696770
148EGFR0.14816524
149ERBB20.13764599
150ALK0.12690040
151RPS6KA40.12488815
152MAP3K30.11185861

Predicted pathways (KEGG)

RankGene SetZ-score
1* ECM-receptor interaction_Homo sapiens_hsa045126.44870385
2Protein digestion and absorption_Homo sapiens_hsa049745.41899178
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005324.63950873
4Folate biosynthesis_Homo sapiens_hsa007903.68769162
5* Focal adhesion_Homo sapiens_hsa045103.42690783
6Collecting duct acid secretion_Homo sapiens_hsa049662.66009781
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.37131770
8* PI3K-Akt signaling pathway_Homo sapiens_hsa041512.09654745
9Malaria_Homo sapiens_hsa051442.08228978
10Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.68310125
11Proteoglycans in cancer_Homo sapiens_hsa052051.65490998
12AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.62394628
13Amoebiasis_Homo sapiens_hsa051461.56183331
14Basal cell carcinoma_Homo sapiens_hsa052171.50274459
15Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.46421115
16Staphylococcus aureus infection_Homo sapiens_hsa051501.46149383
17Bladder cancer_Homo sapiens_hsa052191.45420468
18MicroRNAs in cancer_Homo sapiens_hsa052061.44479396
19Thyroid hormone synthesis_Homo sapiens_hsa049181.41351611
20Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.39678547
21Dilated cardiomyopathy_Homo sapiens_hsa054141.38278135
22Wnt signaling pathway_Homo sapiens_hsa043101.35872867
23TGF-beta signaling pathway_Homo sapiens_hsa043501.35730284
24Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.33922422
25Other glycan degradation_Homo sapiens_hsa005111.32009870
26Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.31865326
27Melanoma_Homo sapiens_hsa052181.30523475
28Prostate cancer_Homo sapiens_hsa052151.29659912
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.23367242
30Hippo signaling pathway_Homo sapiens_hsa043901.19965010
31Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.19064100
32Glioma_Homo sapiens_hsa052141.18887244
33Platelet activation_Homo sapiens_hsa046111.15101409
34Melanogenesis_Homo sapiens_hsa049161.10595913
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08588479
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.07793721
37Prolactin signaling pathway_Homo sapiens_hsa049171.05375870
38Toll-like receptor signaling pathway_Homo sapiens_hsa046201.03890067
39Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.03370006
40Pancreatic secretion_Homo sapiens_hsa049721.00273562
41Sulfur metabolism_Homo sapiens_hsa009200.99449100
42Estrogen signaling pathway_Homo sapiens_hsa049150.98517565
43Hedgehog signaling pathway_Homo sapiens_hsa043400.98343945
44cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97938368
45Adherens junction_Homo sapiens_hsa045200.97664322
46Dorso-ventral axis formation_Homo sapiens_hsa043200.95394244
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.95384359
48Thyroid cancer_Homo sapiens_hsa052160.94598934
49Protein export_Homo sapiens_hsa030600.93978122
50Gap junction_Homo sapiens_hsa045400.93886618
51Viral myocarditis_Homo sapiens_hsa054160.92051035
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.91464560
53Axon guidance_Homo sapiens_hsa043600.91461788
54Phagosome_Homo sapiens_hsa041450.91040438
55Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.90864788
56Central carbon metabolism in cancer_Homo sapiens_hsa052300.90211221
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83326388
58Vibrio cholerae infection_Homo sapiens_hsa051100.81514158
59Chronic myeloid leukemia_Homo sapiens_hsa052200.81145497
60Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80331327
61Tuberculosis_Homo sapiens_hsa051520.79883759
62Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78147475
63Hematopoietic cell lineage_Homo sapiens_hsa046400.76961682
64Cocaine addiction_Homo sapiens_hsa050300.75357834
65Chemokine signaling pathway_Homo sapiens_hsa040620.73278463
66Rap1 signaling pathway_Homo sapiens_hsa040150.73170618
67Insulin resistance_Homo sapiens_hsa049310.73126453
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70950029
69N-Glycan biosynthesis_Homo sapiens_hsa005100.70598749
70Asthma_Homo sapiens_hsa053100.69883871
71Olfactory transduction_Homo sapiens_hsa047400.67911837
72Arginine and proline metabolism_Homo sapiens_hsa003300.64565012
73Allograft rejection_Homo sapiens_hsa053300.64451972
74Aldosterone synthesis and secretion_Homo sapiens_hsa049250.63688296
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62205515
76Graft-versus-host disease_Homo sapiens_hsa053320.61690952
77Pathways in cancer_Homo sapiens_hsa052000.59865635
78Autoimmune thyroid disease_Homo sapiens_hsa053200.59650040
79Pancreatic cancer_Homo sapiens_hsa052120.59385864
80Leishmaniasis_Homo sapiens_hsa051400.59312592
81Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.57845054
82Leukocyte transendothelial migration_Homo sapiens_hsa046700.55936119
83Synaptic vesicle cycle_Homo sapiens_hsa047210.55622256
84Amphetamine addiction_Homo sapiens_hsa050310.54566580
85B cell receptor signaling pathway_Homo sapiens_hsa046620.53818850
86Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.53342931
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.52559182
88Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.48775527
89Toxoplasmosis_Homo sapiens_hsa051450.46429622
90Small cell lung cancer_Homo sapiens_hsa052220.46293185
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45991085
92Non-small cell lung cancer_Homo sapiens_hsa052230.45608924
93HTLV-I infection_Homo sapiens_hsa051660.45433624
94Renin secretion_Homo sapiens_hsa049240.45216899
95Circadian rhythm_Homo sapiens_hsa047100.44722321
96Cholinergic synapse_Homo sapiens_hsa047250.44338786
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.44086846
98Endocytosis_Homo sapiens_hsa041440.42455484
99Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.41723655
100Lysine degradation_Homo sapiens_hsa003100.41560500
101AMPK signaling pathway_Homo sapiens_hsa041520.41156973
102Renal cell carcinoma_Homo sapiens_hsa052110.40868608
103Ras signaling pathway_Homo sapiens_hsa040140.40587872
104Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.40540282
105Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40441220
106Sphingolipid metabolism_Homo sapiens_hsa006000.40122716
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38794107
108HIF-1 signaling pathway_Homo sapiens_hsa040660.38545234
109Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.38221291
110Pertussis_Homo sapiens_hsa051330.38220748
111mTOR signaling pathway_Homo sapiens_hsa041500.37975341
112Calcium signaling pathway_Homo sapiens_hsa040200.37893812
113Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36278417
114ErbB signaling pathway_Homo sapiens_hsa040120.36260157
115Type I diabetes mellitus_Homo sapiens_hsa049400.36153355
116Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36125297
117Hepatitis B_Homo sapiens_hsa051610.35398684
118Adipocytokine signaling pathway_Homo sapiens_hsa049200.35385149
119Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.34869473
120Complement and coagulation cascades_Homo sapiens_hsa046100.34780184
121TNF signaling pathway_Homo sapiens_hsa046680.34228830
122Glucagon signaling pathway_Homo sapiens_hsa049220.33701935
123Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32871886
124Ovarian steroidogenesis_Homo sapiens_hsa049130.32299001
125Renin-angiotensin system_Homo sapiens_hsa046140.32069558
126Oxytocin signaling pathway_Homo sapiens_hsa049210.31727205
127Salmonella infection_Homo sapiens_hsa051320.30514011
128NF-kappa B signaling pathway_Homo sapiens_hsa040640.30483051
129Insulin secretion_Homo sapiens_hsa049110.30159653
130Circadian entrainment_Homo sapiens_hsa047130.29738857
131Lysosome_Homo sapiens_hsa041420.29395004
132Starch and sucrose metabolism_Homo sapiens_hsa005000.29377811
133Rheumatoid arthritis_Homo sapiens_hsa053230.29227487
134GnRH signaling pathway_Homo sapiens_hsa049120.28837491
135Colorectal cancer_Homo sapiens_hsa052100.28683155
136Long-term depression_Homo sapiens_hsa047300.27644243
137Osteoclast differentiation_Homo sapiens_hsa043800.23802652
138Type II diabetes mellitus_Homo sapiens_hsa049300.23125814
139Bile secretion_Homo sapiens_hsa049760.22760117
140Choline metabolism in cancer_Homo sapiens_hsa052310.22673609
141VEGF signaling pathway_Homo sapiens_hsa043700.21452338
142Dopaminergic synapse_Homo sapiens_hsa047280.21263590
143cAMP signaling pathway_Homo sapiens_hsa040240.21258163
144Neurotrophin signaling pathway_Homo sapiens_hsa047220.21180322

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