ICA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with an arfaptin homology domain that is found both in the cytosol and as membrane-bound form on the Golgi complex and immature secretory granules. This protein is believed to be an autoantigen in insulin-dependent diabetes mellitus and primary Sjogren's syndrome. Several transcript variants encoding two different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)5.37066607
2COPI coating of Golgi vesicle (GO:0048205)5.37066607
3regulation of synaptic vesicle exocytosis (GO:2000300)4.55884427
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.49333740
5cellular ketone body metabolic process (GO:0046950)4.45489892
6synaptic vesicle docking involved in exocytosis (GO:0016081)4.35321804
7synaptic vesicle exocytosis (GO:0016079)4.33678150
8regulation of synaptic vesicle transport (GO:1902803)4.09290355
9protein polyglutamylation (GO:0018095)4.02699844
10protein maturation by protein folding (GO:0022417)4.00627509
11regulation of short-term neuronal synaptic plasticity (GO:0048172)4.00458725
12ketone body metabolic process (GO:1902224)3.84896993
13regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.77366310
14water-soluble vitamin biosynthetic process (GO:0042364)3.75256234
15glutamate secretion (GO:0014047)3.66570047
16detection of calcium ion (GO:0005513)3.63862771
17response to pheromone (GO:0019236)3.63749940
18sperm motility (GO:0030317)3.57685918
19respiratory chain complex IV assembly (GO:0008535)3.56641388
20insulin secretion (GO:0030073)3.52351025
21neuron cell-cell adhesion (GO:0007158)3.45806764
22calcium ion-dependent exocytosis (GO:0017156)3.44552365
23ER overload response (GO:0006983)3.41949408
24maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.37915742
25signal peptide processing (GO:0006465)3.35865614
26neuronal action potential propagation (GO:0019227)3.35529963
27energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.32319503
28ATP hydrolysis coupled proton transport (GO:0015991)3.32319503
29transferrin transport (GO:0033572)3.29053671
30retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.29012559
31synaptic transmission, glutamatergic (GO:0035249)3.21232272
32inositol phosphate catabolic process (GO:0071545)3.20888798
33acrosome reaction (GO:0007340)3.20252373
34cytochrome complex assembly (GO:0017004)3.19355522
35protein localization to cilium (GO:0061512)3.17851395
36axoneme assembly (GO:0035082)3.17430310
37protein complex biogenesis (GO:0070271)3.17028659
38regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.16962398
39neuron-neuron synaptic transmission (GO:0007270)3.13877276
40regulation of calcium ion-dependent exocytosis (GO:0017158)3.12784276
41neurotransmitter-gated ion channel clustering (GO:0072578)3.12609065
42neurotransmitter secretion (GO:0007269)3.10667867
43peptide hormone processing (GO:0016486)3.10170890
44vocalization behavior (GO:0071625)3.09933303
45regulation of glutamate receptor signaling pathway (GO:1900449)3.07689227
46regulation of insulin secretion (GO:0050796)3.06452405
47establishment of protein localization to Golgi (GO:0072600)3.06311185
48postsynaptic membrane organization (GO:0001941)3.05135311
49lactate metabolic process (GO:0006089)3.03609394
50positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.03451861
51trivalent inorganic cation transport (GO:0072512)3.02929769
52ferric iron transport (GO:0015682)3.02929769
53aggressive behavior (GO:0002118)3.02598205
54protein localization to synapse (GO:0035418)2.99737141
55negative regulation of dendrite morphogenesis (GO:0050774)2.99471108
56intra-Golgi vesicle-mediated transport (GO:0006891)2.99319904
57gamma-aminobutyric acid signaling pathway (GO:0007214)2.99011035
58behavioral response to nicotine (GO:0035095)2.98803183
59protein targeting to Golgi (GO:0000042)2.98143648
60synaptic vesicle maturation (GO:0016188)2.95735976
61protein retention in ER lumen (GO:0006621)2.95379429
62presynaptic membrane assembly (GO:0097105)2.95180585
63detection of light stimulus involved in sensory perception (GO:0050962)2.92932037
64detection of light stimulus involved in visual perception (GO:0050908)2.92932037
65endocrine pancreas development (GO:0031018)2.91959665
66regulation of glucokinase activity (GO:0033131)2.89347236
67regulation of hexokinase activity (GO:1903299)2.89347236
68L-fucose catabolic process (GO:0042355)2.89074093
69fucose catabolic process (GO:0019317)2.89074093
70L-fucose metabolic process (GO:0042354)2.89074093
71positive regulation of insulin secretion (GO:0032024)2.88315502
72piRNA metabolic process (GO:0034587)2.86988330
73mitochondrial respiratory chain complex assembly (GO:0033108)2.86778419
74exocrine pancreas development (GO:0031017)2.85627797
75regulation of exocytosis (GO:0017157)2.85148379
76synaptic vesicle transport (GO:0048489)2.84613786
77establishment of synaptic vesicle localization (GO:0097480)2.84613786
78startle response (GO:0001964)2.84529742
79positive regulation of neurotransmitter secretion (GO:0001956)2.84119647
80regulation of glucocorticoid secretion (GO:2000849)2.83921699
81regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.83299018
82seminiferous tubule development (GO:0072520)2.82635092
83positive regulation of synaptic transmission, GABAergic (GO:0032230)2.81471266
84regulation of vesicle fusion (GO:0031338)2.81337323
85negative regulation of cytosolic calcium ion concentration (GO:0051481)2.81249634
86positive regulation of exocytosis (GO:0045921)2.80223990
87DNA methylation involved in gamete generation (GO:0043046)2.79553765
88positive regulation of neurotransmitter transport (GO:0051590)2.79482494
89innervation (GO:0060384)2.79306287
90regulation of peptide hormone secretion (GO:0090276)2.79283953
91prostate gland growth (GO:0060736)2.79103284
92retrograde transport, vesicle recycling within Golgi (GO:0000301)2.78801384
93regulation of cilium movement (GO:0003352)2.77693393
94xenobiotic catabolic process (GO:0042178)2.77689107
95urinary tract smooth muscle contraction (GO:0014848)2.77365538
96regulation of peptide secretion (GO:0002791)2.75923444
97preassembly of GPI anchor in ER membrane (GO:0016254)2.75867532
98mannosylation (GO:0097502)2.75437589
99regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.74407059
100regulation of cAMP-dependent protein kinase activity (GO:2000479)2.73959878
101short-chain fatty acid metabolic process (GO:0046459)2.72999470
102inositol phosphate dephosphorylation (GO:0046855)2.72127013
103phosphorylated carbohydrate dephosphorylation (GO:0046838)2.72127013
104mitochondrial respiratory chain complex I assembly (GO:0032981)2.72072591
105NADH dehydrogenase complex assembly (GO:0010257)2.72072591
106mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.72072591
107melanosome transport (GO:0032402)2.71793161
108regulation of oxidative phosphorylation (GO:0002082)2.71768730
109long-term synaptic potentiation (GO:0060291)2.71419188
110DNA deamination (GO:0045006)2.71231224
111branched-chain amino acid catabolic process (GO:0009083)2.71014247
112rRNA methylation (GO:0031167)2.70851326
113activation of protein kinase A activity (GO:0034199)2.70837003
114positive regulation of glycolytic process (GO:0045821)2.70266163
115polyol catabolic process (GO:0046174)2.69858155
116intraciliary transport (GO:0042073)2.69427871
117single strand break repair (GO:0000012)2.69171915
118establishment of melanosome localization (GO:0032401)2.68656104
119regulation of neurotransmitter secretion (GO:0046928)2.68539933
120positive regulation of membrane potential (GO:0045838)2.67947951
121GDP-mannose metabolic process (GO:0019673)2.67931472
122protein localization to Golgi apparatus (GO:0034067)2.67604484
123membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.66891566
124rRNA modification (GO:0000154)2.65876549
125GPI anchor metabolic process (GO:0006505)2.65192176
126multicellular organism reproduction (GO:0032504)2.64089887
127primary amino compound metabolic process (GO:1901160)2.63763773
128positive regulation of prostaglandin secretion (GO:0032308)2.62816383
129L-alpha-amino acid transmembrane transport (GO:1902475)2.61878826
130indolalkylamine metabolic process (GO:0006586)2.60633055
131behavioral response to ethanol (GO:0048149)2.60005978
132serotonin metabolic process (GO:0042428)2.59923338
133spermatid development (GO:0007286)2.59875502
134peptide hormone secretion (GO:0030072)2.59193004
135striatum development (GO:0021756)2.58292930
136chaperone-mediated protein transport (GO:0072321)2.57873626
137presynaptic membrane organization (GO:0097090)2.57754481
138pigment granule transport (GO:0051904)2.57393162
139locomotory exploration behavior (GO:0035641)2.57313408
140positive regulation of vesicle fusion (GO:0031340)2.55795213
141righting reflex (GO:0060013)2.55353704
142establishment of pigment granule localization (GO:0051905)2.55053244
143cardiac conduction (GO:0061337)2.54214280
144regulation of neurotransmitter transport (GO:0051588)2.53632026
145phosphorelay signal transduction system (GO:0000160)2.53614348
146regulation of type B pancreatic cell apoptotic process (GO:2000674)2.53490893
147vesicle coating (GO:0006901)2.53445210
148regulation of hormone secretion (GO:0046883)2.53243102
149establishment of vesicle localization (GO:0051650)2.53030306
150cellular response to glucagon stimulus (GO:0071377)2.52341782
151signal release (GO:0023061)2.52211096
152platelet dense granule organization (GO:0060155)2.51485529
153glycerophospholipid catabolic process (GO:0046475)2.48688236
154phosphatidylethanolamine biosynthetic process (GO:0006646)2.47972155
155phosphatidylethanolamine metabolic process (GO:0046337)2.45381237
156organic cation transport (GO:0015695)2.43979142
157glutathione derivative biosynthetic process (GO:1901687)2.43238522
158glutathione derivative metabolic process (GO:1901685)2.43238522
159proline transport (GO:0015824)2.41220847
160calcium ion import (GO:0070509)2.39953769
161reflex (GO:0060004)2.39464792
162nitric oxide mediated signal transduction (GO:0007263)2.38692952
163purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.37905844
1643-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.37905844
165GPI anchor biosynthetic process (GO:0006506)2.37692272
166epithelial cilium movement (GO:0003351)2.36611750
167alanine transport (GO:0032328)2.36287974
168positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.35509731
169tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.35493362
170RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.35493362
171regulation of female receptivity (GO:0045924)2.34606910
172positive regulation of meiosis (GO:0045836)2.34041273
173regulation of heart rate by cardiac conduction (GO:0086091)2.32978742
174ubiquinone biosynthetic process (GO:0006744)2.32654523
175regulation of acrosome reaction (GO:0060046)2.32504246
176fusion of sperm to egg plasma membrane (GO:0007342)2.32484508
177regulation of action potential (GO:0098900)2.32150786
178indole-containing compound metabolic process (GO:0042430)2.31710727
179mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.30692084
180peroxisome fission (GO:0016559)2.30644863
181negative regulation of neurological system process (GO:0031645)2.30577785
182neuronal action potential (GO:0019228)2.29604820
183glandular epithelial cell differentiation (GO:0002067)2.28205545
184membrane depolarization during action potential (GO:0086010)2.27604377
185action potential (GO:0001508)2.27335489
186positive regulation of fatty acid transport (GO:2000193)2.26891736
187positive regulation of glomerulus development (GO:0090193)2.24519568

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.53251853
2GBX2_23144817_ChIP-Seq_PC3_Human4.32680539
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.22487216
4REST_21632747_ChIP-Seq_MESCs_Mouse2.68606286
5TAF15_26573619_Chip-Seq_HEK293_Human2.67466985
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.64070153
7CTBP2_25329375_ChIP-Seq_LNCAP_Human2.31959131
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.24938467
9* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.21274987
10IGF1R_20145208_ChIP-Seq_DFB_Human2.21253240
11REST_18959480_ChIP-ChIP_MESCs_Mouse2.14124881
12* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.12613467
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.11826236
14PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.10678452
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.97829879
16BMI1_23680149_ChIP-Seq_NPCS_Mouse1.91237982
17* ER_23166858_ChIP-Seq_MCF-7_Human1.91183980
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.86580002
19PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.86495664
20* SMAD4_21799915_ChIP-Seq_A2780_Human1.85777473
21CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.84709447
22* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.75213858
23RARB_27405468_Chip-Seq_BRAIN_Mouse1.73269459
24FUS_26573619_Chip-Seq_HEK293_Human1.72493538
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.71625747
26* P300_19829295_ChIP-Seq_ESCs_Human1.71312381
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70599257
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.69124971
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.67445760
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.63111073
31* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.61739936
32VDR_22108803_ChIP-Seq_LS180_Human1.59360269
33JARID2_20064375_ChIP-Seq_MESCs_Mouse1.54290736
34FOXA1_25329375_ChIP-Seq_VCAP_Human1.53592895
35FOXA1_27270436_Chip-Seq_PROSTATE_Human1.53592895
36FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.50600552
37RNF2_27304074_Chip-Seq_NSC_Mouse1.50581585
38SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.50562116
39* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.49173174
40JARID2_20075857_ChIP-Seq_MESCs_Mouse1.48075005
41* SOX2_19829295_ChIP-Seq_ESCs_Human1.47268556
42* NANOG_19829295_ChIP-Seq_ESCs_Human1.47268556
43* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.47091939
44BCAT_22108803_ChIP-Seq_LS180_Human1.44819136
45FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.43137783
46STAT3_23295773_ChIP-Seq_U87_Human1.42933813
47ZNF274_21170338_ChIP-Seq_K562_Hela1.42710641
48SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.42523911
49EZH2_27304074_Chip-Seq_ESCs_Mouse1.41611486
50* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.41175642
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.39960139
52TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39100209
53EZH2_27294783_Chip-Seq_ESCs_Mouse1.38856245
54* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.38205505
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.36939909
56E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.36764058
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.34719111
58AR_25329375_ChIP-Seq_VCAP_Human1.33585404
59PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32195506
60NANOG_18555785_Chip-Seq_ESCs_Mouse1.31268762
61SUZ12_27294783_Chip-Seq_ESCs_Mouse1.29045494
62TCF4_23295773_ChIP-Seq_U87_Human1.28939886
63KLF5_20875108_ChIP-Seq_MESCs_Mouse1.28063386
64MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27861330
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27689348
66AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25724833
67TCF4_22108803_ChIP-Seq_LS180_Human1.24903139
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24285729
69* GATA3_21878914_ChIP-Seq_MCF-7_Human1.24093764
70EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23390126
71* CDX2_22108803_ChIP-Seq_LS180_Human1.23165350
72IRF1_19129219_ChIP-ChIP_H3396_Human1.23077709
73HTT_18923047_ChIP-ChIP_STHdh_Human1.23066212
74NCOR_22424771_ChIP-Seq_293T_Human1.22653929
75SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.22086725
76NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21217763
77SOX2_21211035_ChIP-Seq_LN229_Gbm1.20953939
78SMAD3_21741376_ChIP-Seq_EPCs_Human1.20317337
79P53_22387025_ChIP-Seq_ESCs_Mouse1.20006719
80AR_20517297_ChIP-Seq_VCAP_Human1.19977687
81NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.19803436
82HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.18424825
83EGR1_23403033_ChIP-Seq_LIVER_Mouse1.16645498
84SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.16166605
85CDX2_19796622_ChIP-Seq_MESCs_Mouse1.15838754
86AHR_22903824_ChIP-Seq_MCF-7_Human1.15643406
87MYC_19829295_ChIP-Seq_ESCs_Human1.15511136
88ARNT_22903824_ChIP-Seq_MCF-7_Human1.15322435
89SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15195740
90STAT3_18555785_Chip-Seq_ESCs_Mouse1.15088594
91TP53_22573176_ChIP-Seq_HFKS_Human1.14040819
92ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13808195
93* DROSHA_22980978_ChIP-Seq_HELA_Human1.13638067
94KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.13628015
95RNF2_27304074_Chip-Seq_ESCs_Mouse1.13492215
96IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13487856
97ETV2_25802403_ChIP-Seq_MESCs_Mouse1.13476857
98SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13116410
99NFE2_27457419_Chip-Seq_LIVER_Mouse1.12704425
100HOXB7_26014856_ChIP-Seq_BT474_Human1.12690338
101CBX2_27304074_Chip-Seq_ESCs_Mouse1.12571510
102CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.12467408
103SMAD4_21741376_ChIP-Seq_EPCs_Human1.12413716
104ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12352769
105RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.12344153
106DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.11597269
107AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.11546778
108REST_19997604_ChIP-ChIP_NEURONS_Mouse1.11200821
109SRF_21415370_ChIP-Seq_HL-1_Mouse1.10777800
110SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.10225717
111RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.09961788
112TAL1_26923725_Chip-Seq_HPCs_Mouse1.09152967
113CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.08840672
114GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07931151
115EZH2_18974828_ChIP-Seq_MESCs_Mouse1.07143041
116RNF2_18974828_ChIP-Seq_MESCs_Mouse1.07143041
117KDM2B_26808549_Chip-Seq_REH_Human1.06941779
118SOX2_18555785_Chip-Seq_ESCs_Mouse1.06751108
119CBP_20019798_ChIP-Seq_JUKART_Human1.06725588
120IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06725588
121RUNX2_22187159_ChIP-Seq_PCA_Human1.05196931
122FLI1_21867929_ChIP-Seq_TH2_Mouse1.04907284
123EZH2_27294783_Chip-Seq_NPCs_Mouse1.04686784
124E2F1_18555785_Chip-Seq_ESCs_Mouse1.04248651
125PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03798308
126* JUN_21703547_ChIP-Seq_K562_Human1.03776760
127SALL1_21062744_ChIP-ChIP_HESCs_Human1.03687437
128CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03299863
129MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02682684
130CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02488317
131RBPJ_21746931_ChIP-Seq_IB4_Human1.02153047
132MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01589349
133PHF8_20622853_ChIP-Seq_HELA_Human1.01197461
134* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00380301
135UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00284211
136TAF2_19829295_ChIP-Seq_ESCs_Human1.00279354
137CMYC_18555785_Chip-Seq_ESCs_Mouse0.99483395
138GABP_17652178_ChIP-ChIP_JURKAT_Human0.99024534
139RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.98588248
140NANOG_20526341_ChIP-Seq_ESCs_Human0.98346369
141ERG_20517297_ChIP-Seq_VCAP_Human0.98222078
142SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98029026
143YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97702465
144* PRDM14_20953172_ChIP-Seq_ESCs_Human0.97605194
145EED_16625203_ChIP-ChIP_MESCs_Mouse0.97515687
146CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.97334681
147TDRD3_21172665_ChIP-Seq_MCF-7_Human0.97204981
148ETV1_20927104_ChIP-Seq_GIST48_Human0.97057488
149NMYC_18555785_Chip-Seq_ESCs_Mouse0.96473116
150MYC_18940864_ChIP-ChIP_HL60_Human0.96229879
151SMAD3_21741376_ChIP-Seq_ESCs_Human0.96137874
152EWS_26573619_Chip-Seq_HEK293_Human0.96064344
153* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95886188

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.47562593
2MP0010386_abnormal_urinary_bladder3.44860107
3MP0003880_abnormal_central_pattern3.29277364
4MP0004270_analgesia2.81053797
5MP0003635_abnormal_synaptic_transmissio2.75114796
6MP0005646_abnormal_pituitary_gland2.67880926
7MP0000013_abnormal_adipose_tissue2.67832333
8MP0005670_abnormal_white_adipose2.64748746
9MP0001968_abnormal_touch/_nociception2.49159558
10MP0003787_abnormal_imprinting2.44832584
11MP0003195_calcinosis2.43273345
12MP0002909_abnormal_adrenal_gland2.42743665
13MP0003183_abnormal_peptide_metabolism2.40007024
14MP0002837_dystrophic_cardiac_calcinosis2.36776652
15MP0009745_abnormal_behavioral_response2.35461877
16MP0002693_abnormal_pancreas_physiology2.28404486
17MP0002736_abnormal_nociception_after2.26778907
18MP0009780_abnormal_chondrocyte_physiolo2.26321428
19MP0002063_abnormal_learning/memory/cond2.22182819
20MP0002734_abnormal_mechanical_nocicepti2.21609388
21MP0003122_maternal_imprinting2.21366980
22MP0004043_abnormal_pH_regulation2.16337376
23MP0001188_hyperpigmentation2.12200022
24MP0005645_abnormal_hypothalamus_physiol2.10403661
25MP0002572_abnormal_emotion/affect_behav2.09218128
26MP0002638_abnormal_pupillary_reflex2.06069053
27MP0006276_abnormal_autonomic_nervous2.00537185
28MP0002064_seizures1.99936266
29MP0002735_abnormal_chemical_nociception1.98767900
30MP0009046_muscle_twitch1.96651354
31MP0001944_abnormal_pancreas_morphology1.95296605
32MP0002822_catalepsy1.93861012
33MP0008872_abnormal_physiological_respon1.93230422
34MP0002272_abnormal_nervous_system1.91525264
35MP0004147_increased_porphyrin_level1.88888653
36MP0002877_abnormal_melanocyte_morpholog1.87898065
37MP0008877_abnormal_DNA_methylation1.87044202
38MP0001986_abnormal_taste_sensitivity1.84673325
39MP0003718_maternal_effect1.82054756
40MP0003879_abnormal_hair_cell1.81340211
41MP0005379_endocrine/exocrine_gland_phen1.79005387
42MP0001501_abnormal_sleep_pattern1.76176491
43MP0001529_abnormal_vocalization1.73044533
44MP0002733_abnormal_thermal_nociception1.65421204
45MP0001984_abnormal_olfaction1.65105996
46MP0002067_abnormal_sensory_capabilities1.64489998
47MP0001970_abnormal_pain_threshold1.62937939
48MP0002876_abnormal_thyroid_physiology1.62758110
49MP0006072_abnormal_retinal_apoptosis1.60325512
50MP0000516_abnormal_urinary_system1.59140174
51MP0005367_renal/urinary_system_phenotyp1.59140174
52MP0002254_reproductive_system_inflammat1.56680672
53MP0005220_abnormal_exocrine_pancreas1.52632315
54MP0003011_delayed_dark_adaptation1.52525733
55MP0000678_abnormal_parathyroid_gland1.47301896
56MP0002557_abnormal_social/conspecific_i1.47098383
57MP0002184_abnormal_innervation1.46337546
58MP0001502_abnormal_circadian_rhythm1.44580270
59MP0008995_early_reproductive_senescence1.42132304
60MP0001486_abnormal_startle_reflex1.40165493
61MP0004885_abnormal_endolymph1.37804721
62MP0005636_abnormal_mineral_homeostasis1.37360770
63MP0006036_abnormal_mitochondrial_physio1.36910185
64MP0001664_abnormal_digestion1.32989476
65MP0004924_abnormal_behavior1.30098344
66MP0005386_behavior/neurological_phenoty1.30098344
67MP0002102_abnormal_ear_morphology1.29567806
68MP0000631_abnormal_neuroendocrine_gland1.27412087
69MP0005084_abnormal_gallbladder_morpholo1.25850406
70MP0002160_abnormal_reproductive_system1.25694390
71MP0003121_genomic_imprinting1.24262597
72MP0002138_abnormal_hepatobiliary_system1.23146696
73MP0006292_abnormal_olfactory_placode1.21580240
74MP0001440_abnormal_grooming_behavior1.20790533
75MP0001905_abnormal_dopamine_level1.20775565
76MP0004811_abnormal_neuron_physiology1.20519232
77MP0003283_abnormal_digestive_organ1.19374191
78MP0005332_abnormal_amino_acid1.17712935
79MP0003123_paternal_imprinting1.16806582
80* MP0002078_abnormal_glucose_homeostasis1.16325836
81MP0004264_abnormal_extraembryonic_tissu1.11510092
82MP0001765_abnormal_ion_homeostasis1.11504425
83MP0008569_lethality_at_weaning1.10916001
84MP0004019_abnormal_vitamin_homeostasis1.10773910
85MP0000569_abnormal_digit_pigmentation1.08370453
86MP0001929_abnormal_gametogenesis1.07167363
87MP0000955_abnormal_spinal_cord1.06889193
88MP0008775_abnormal_heart_ventricle1.06769914
89MP0001756_abnormal_urination1.01904011
90MP0000230_abnormal_systemic_arterial1.01006518
91MP0005389_reproductive_system_phenotype1.00931858
92MP0008875_abnormal_xenobiotic_pharmacok1.00693455
93MP0000015_abnormal_ear_pigmentation0.99797124
94MP0010329_abnormal_lipoprotein_level0.99791291
95MP0003953_abnormal_hormone_level0.99478309
96MP0005535_abnormal_body_temperature0.99230947
97MP0002163_abnormal_gland_morphology0.98889327
98MP0005410_abnormal_fertilization0.97755563
99MP0005365_abnormal_bile_salt0.96823864
100MP0005310_abnormal_salivary_gland0.92624201
101MP0005423_abnormal_somatic_nervous0.92263201
102MP0004145_abnormal_muscle_electrophysio0.91880683
103MP0005075_abnormal_melanosome_morpholog0.89295650
104MP0002066_abnormal_motor_capabilities/c0.88487179
105MP0004085_abnormal_heartbeat0.87487015
106MP0005551_abnormal_eye_electrophysiolog0.86729525
107MP0003646_muscle_fatigue0.86301714
108MP0008004_abnormal_stomach_pH0.86296536
109MP0002882_abnormal_neuron_morphology0.85947036
110MP0000383_abnormal_hair_follicle0.85383720
111MP0001764_abnormal_homeostasis0.85204027
112MP0004142_abnormal_muscle_tone0.82349836
113MP0002069_abnormal_eating/drinking_beha0.81111452
114MP0000613_abnormal_salivary_gland0.80693805
115MP0001919_abnormal_reproductive_system0.79818498
116MP0001666_abnormal_nutrient_absorption0.79383023
117MP0009697_abnormal_copulation0.79301183
118MP0003633_abnormal_nervous_system0.78261378
119MP0002139_abnormal_hepatobiliary_system0.78232431
120MP0000003_abnormal_adipose_tissue0.77180053
121MP0002277_abnormal_respiratory_mucosa0.76665843
122MP0000653_abnormal_sex_gland0.76591008
123MP0003868_abnormal_feces_composition0.76333654
124MP0002751_abnormal_autonomic_nervous0.76292980
125MP0003698_abnormal_male_reproductive0.75997413
126MP0000681_abnormal_thyroid_gland0.75160589
127MP0003172_abnormal_lysosome_physiology0.74269041
128MP0005448_abnormal_energy_balance0.73492908
129MP0002653_abnormal_ependyma_morphology0.72921854
130MP0002229_neurodegeneration0.72569750
131MP0004215_abnormal_myocardial_fiber0.72334796
132MP0001485_abnormal_pinna_reflex0.72183688
133MP0000372_irregular_coat_pigmentation0.71587593
134MP0003890_abnormal_embryonic-extraembry0.71191356
135MP0005253_abnormal_eye_physiology0.69930121
136MP0008961_abnormal_basal_metabolism0.68427623

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.20928907
2Visual hallucinations (HP:0002367)4.19584832
3Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.87198471
4Atonic seizures (HP:0010819)3.68764116
5Epileptic encephalopathy (HP:0200134)3.64321309
6Hypothermia (HP:0002045)3.51090248
7Febrile seizures (HP:0002373)3.40745111
8Hyperinsulinemic hypoglycemia (HP:0000825)3.32747214
9Symptomatic seizures (HP:0011145)3.25255109
10Congenital stationary night blindness (HP:0007642)3.23098435
11Medial flaring of the eyebrow (HP:0010747)3.19361250
12Hypoglycemic coma (HP:0001325)3.06952946
13Abnormal rod and cone electroretinograms (HP:0008323)3.02445018
14Abnormality of calcium-phosphate metabolism (HP:0100530)2.96354848
15Epileptiform EEG discharges (HP:0011182)2.95704465
16Gait imbalance (HP:0002141)2.93038941
17Hypoglycemic seizures (HP:0002173)2.90654159
18Ketosis (HP:0001946)2.88975094
19EEG with generalized epileptiform discharges (HP:0011198)2.83512538
20Decreased circulating renin level (HP:0003351)2.83475876
21Focal seizures (HP:0007359)2.82383910
22Agitation (HP:0000713)2.80325879
23Congenital primary aphakia (HP:0007707)2.79158192
24Absence seizures (HP:0002121)2.75187471
25Acute necrotizing encephalopathy (HP:0006965)2.73814482
26Hyperventilation (HP:0002883)2.73577768
27Abnormal mitochondria in muscle tissue (HP:0008316)2.72583518
28Pheochromocytoma (HP:0002666)2.70700616
29Insulin-resistant diabetes mellitus (HP:0000831)2.70621632
30Methylmalonic acidemia (HP:0002912)2.70612230
31Neuroendocrine neoplasm (HP:0100634)2.68774145
32Menstrual irregularities (HP:0000858)2.66589363
33Chronic bronchitis (HP:0004469)2.65676993
34Hypsarrhythmia (HP:0002521)2.65410891
35Attenuation of retinal blood vessels (HP:0007843)2.64807522
36Nephrogenic diabetes insipidus (HP:0009806)2.63747156
37Nephronophthisis (HP:0000090)2.60891931
38Myokymia (HP:0002411)2.59790518
39Abnormality of the renal cortex (HP:0011035)2.50993162
40Large for gestational age (HP:0001520)2.50983733
41Type II lissencephaly (HP:0007260)2.43841075
42Dialeptic seizures (HP:0011146)2.41877196
43Abnormality of vitamin B metabolism (HP:0004340)2.41374099
44Progressive cerebellar ataxia (HP:0002073)2.41361103
45Abnormality of macular pigmentation (HP:0008002)2.40867430
46Generalized tonic-clonic seizures (HP:0002069)2.36439601
47Abolished electroretinogram (ERG) (HP:0000550)2.36227133
48Methylmalonic aciduria (HP:0012120)2.36131354
49Cortical visual impairment (HP:0100704)2.35786017
50Hepatic necrosis (HP:0002605)2.34009513
51Pancreatic fibrosis (HP:0100732)2.31626010
52Progressive macrocephaly (HP:0004481)2.31487844
53Hypoplasia of the fovea (HP:0007750)2.30630519
54Aplasia/Hypoplasia of the fovea (HP:0008060)2.30630519
55Failure to thrive in infancy (HP:0001531)2.30222319
56Mitochondrial inheritance (HP:0001427)2.29446438
57Abnormality of the fovea (HP:0000493)2.29339095
58Abnormality of endocrine pancreas physiology (HP:0012093)2.27945183
59Abnormality of the pancreatic islet cells (HP:0006476)2.27945183
60Abnormality of the renal medulla (HP:0100957)2.26680082
61Hyperglycemia (HP:0003074)2.26505697
62Severe visual impairment (HP:0001141)2.24758843
63Poor suck (HP:0002033)2.24193386
64Anxiety (HP:0000739)2.19829175
65Ketoacidosis (HP:0001993)2.19646629
66Abnormal hair whorl (HP:0010721)2.18440461
67Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.18348312
68Absent/shortened dynein arms (HP:0200106)2.16594665
69Dynein arm defect of respiratory motile cilia (HP:0012255)2.16594665
70Renal cortical cysts (HP:0000803)2.16211146
71Protruding tongue (HP:0010808)2.16094337
72Gaze-evoked nystagmus (HP:0000640)2.15563629
73Molar tooth sign on MRI (HP:0002419)2.14775938
74Abnormality of midbrain morphology (HP:0002418)2.14775938
75Abnormality of urine glucose concentration (HP:0011016)2.11398827
76Glycosuria (HP:0003076)2.11398827
77Blue irides (HP:0000635)2.11225574
78Bony spicule pigmentary retinopathy (HP:0007737)2.11140363
79Oligomenorrhea (HP:0000876)2.09718340
80True hermaphroditism (HP:0010459)2.09231163
81Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.07058549
82Short 1st metacarpal (HP:0010034)2.07058549
83Syncope (HP:0001279)2.06325931
84Hypoplasia of the pons (HP:0012110)2.04679758
85Abnormal respiratory motile cilium physiology (HP:0012261)2.04356263
86Acute encephalopathy (HP:0006846)2.03665806
87Genital tract atresia (HP:0001827)2.02377589
88Absent eyebrow (HP:0002223)2.02162011
89Increased CSF lactate (HP:0002490)2.02146096
90Chronic hepatic failure (HP:0100626)2.01480215
91Lipid accumulation in hepatocytes (HP:0006561)2.01296706
92Poor coordination (HP:0002370)2.01241904
93Abnormal pancreas size (HP:0012094)2.01132117
94Vaginal atresia (HP:0000148)2.01122635
95Generalized hypopigmentation of hair (HP:0011358)2.00836765
96Retinal dysplasia (HP:0007973)1.99881018
97Limb dystonia (HP:0002451)1.99177484
98Growth hormone excess (HP:0000845)1.97802722
99Depression (HP:0000716)1.97347035
100Aplasia/hypoplasia of the uterus (HP:0008684)1.97132255
101Tachypnea (HP:0002789)1.96991675
102Type I transferrin isoform profile (HP:0003642)1.96136663
103Pancreatic cysts (HP:0001737)1.93661187
104Rhinitis (HP:0012384)1.93570958
105Papillary thyroid carcinoma (HP:0002895)1.92841383
106Abnormal respiratory epithelium morphology (HP:0012253)1.92763638
107Abnormal respiratory motile cilium morphology (HP:0005938)1.92763638
108Hyperphosphatemia (HP:0002905)1.92461142
109Increased hepatocellular lipid droplets (HP:0006565)1.91983340
110Congenital sensorineural hearing impairment (HP:0008527)1.91219513
111Hyperglycinuria (HP:0003108)1.90420497
112Decreased central vision (HP:0007663)1.90162924
113Abnormality of the 1st metacarpal (HP:0010009)1.89898022
114Infertility (HP:0000789)1.89804878
115Hepatocellular necrosis (HP:0001404)1.89166585
116Pendular nystagmus (HP:0012043)1.88535719
117Abnormal protein glycosylation (HP:0012346)1.88383615
118Abnormal glycosylation (HP:0012345)1.88383615
119Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.88383615
120Abnormal protein N-linked glycosylation (HP:0012347)1.88383615
121Tubulointerstitial nephritis (HP:0001970)1.87922162
122Impaired smooth pursuit (HP:0007772)1.87908942
123Hemiparesis (HP:0001269)1.86280077
124Abnormality of the vitamin B12 metabolism (HP:0004341)1.86177577
125Truncal ataxia (HP:0002078)1.85686399
126Spinal canal stenosis (HP:0003416)1.85050955
127Abnormality of dicarboxylic acid metabolism (HP:0010995)1.84998938
128Dicarboxylic aciduria (HP:0003215)1.84998938
129Late onset (HP:0003584)1.84883820
130Pancreatic islet-cell hyperplasia (HP:0004510)1.84559526
131Hypomagnesemia (HP:0002917)1.84005362
132Goiter (HP:0000853)1.83925708
133Muscular hypotonia of the trunk (HP:0008936)1.82988892
134Aplasia/Hypoplasia of the lens (HP:0008063)1.82603917
135Amblyopia (HP:0000646)1.81680448
136Abnormality of vitamin metabolism (HP:0100508)1.81657206
137Hypoplasia of the uterus (HP:0000013)1.80747708
138Unsteady gait (HP:0002317)1.80273896
139Abnormality of renin-angiotensin system (HP:0000847)1.80271975
140Abnormal ciliary motility (HP:0012262)1.79867769
141Cerebral edema (HP:0002181)1.79736609
1423-Methylglutaconic aciduria (HP:0003535)1.79491569
143Abnormality of glycine metabolism (HP:0010895)1.78952137
144Abnormality of serine family amino acid metabolism (HP:0010894)1.78952137
145Lethargy (HP:0001254)1.78706392
146Testicular neoplasm (HP:0010788)1.78529977
147Cystic liver disease (HP:0006706)1.76983225
148Tubular atrophy (HP:0000092)1.76610050
149Genetic anticipation (HP:0003743)1.76193953
150Polydipsia (HP:0001959)1.75950891
151Abnormal drinking behavior (HP:0030082)1.75950891
152Hyperglycinemia (HP:0002154)1.75379896
153Abnormality of aromatic amino acid family metabolism (HP:0004338)1.74292335
154Intestinal atresia (HP:0011100)1.73570131
155Decreased electroretinogram (ERG) amplitude (HP:0000654)1.73463996
156Renal Fanconi syndrome (HP:0001994)1.72170064

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.76850318
2CASK3.51964600
3MAP3K123.44523218
4MAP2K73.21501670
5MAP4K23.18940850
6AKT33.13375712
7GRK12.98754504
8INSRR2.88468543
9MAP3K42.84182127
10CAMKK22.34826419
11PINK12.24116250
12BRAF2.11694949
13MST42.08420638
14DAPK12.01044782
15NUAK11.87397209
16EPHA41.87123056
17ARAF1.86314773
18PRKD31.80828890
19PASK1.78689450
20STK391.78568650
21TAOK31.77982827
22OXSR11.75453763
23ZAK1.72958135
24WNK31.70427522
25CCNB11.67629547
26MINK11.67601542
27SIK31.66809791
28PLK41.63651323
29MAP3K91.59388779
30STK161.58444355
31MAP2K41.56617261
32MAPK151.55501645
33MAP3K21.49378516
34MAPK131.48786453
35BMPR21.48457023
36PLK21.46927643
37VRK21.44895368
38DAPK21.43616484
39NEK11.43086677
40PHKG21.42289963
41PHKG11.42289963
42BRSK21.40846518
43BMPR1B1.38426118
44CDK191.35016160
45TLK11.30376241
46PAK31.29191812
47NME11.25914882
48MARK11.23318552
49TIE11.21282217
50MUSK1.20637598
51CDK81.17212324
52CAMKK11.16636005
53SGK21.15950774
54NTRK11.14698586
55FRK1.13539853
56SCYL21.08552973
57KSR21.07584235
58TSSK61.07171859
59GRK51.06225566
60MAP3K11.04630438
61EIF2AK31.03508880
62TEC1.02735438
63BRSK11.02281141
64MAP3K61.01708967
65HIPK20.98792090
66CSNK1G20.98117111
67KSR10.94785765
68CSNK1G10.87119563
69PDK30.86458768
70PDK40.86458768
71CSNK1G30.85742442
72PIK3CA0.85214251
73TNIK0.83842229
74RIPK40.83547740
75ERBB30.82383057
76FGFR20.81593968
77CDK50.81135543
78DYRK20.80704990
79MAPKAPK30.80605783
80UHMK10.80084245
81SGK4940.80076641
82SGK2230.80076641
83CAMK2A0.78123688
84PRKCG0.75334665
85BCR0.72977343
86PRKCE0.72763766
87PIK3CG0.68777433
88PRKAA20.67873357
89CAMK1G0.66281825
90WNK40.66108126
91TXK0.64840497
92CSNK1A10.62087616
93VRK10.60865083
94CAMK2B0.60455866
95NTRK20.59945415
96RPS6KA20.59490739
97RET0.59368967
98PTK2B0.59358997
99TRIM280.59011920
100EIF2AK10.57640653
101CAMK10.56672837
102TAF10.55907010
103MYLK0.55823738
104KDR0.55708800
105RAF10.55442070
106RPS6KB10.55368401
107FES0.54960992
108DYRK1A0.52403094
109NLK0.51760343
110PRKACA0.50978208
111RPS6KA50.50454672
112PRKCA0.49899673
113BCKDK0.49712272
114CAMK2D0.49606407
115MAP2K10.49572658
116STK380.49362819
117CSNK1A1L0.49024202
118PRPF4B0.49005423
119ADRBK20.48628806
120ACVR1B0.48356684
121EPHA30.48356563
122CAMK1D0.44740002
123TNK20.44591367
124CDK30.43472325
125PLK30.43374964
126MAP2K60.43290708
127TRPM70.43155217
128ADRBK10.42240392
129NEK60.42207527
130CDC42BPA0.40701568
131PRKAA10.40214985
132PAK60.39749742
133FLT30.39029353
134PDK20.38664933
135STK38L0.37663204
136MAPKAPK50.37257387
137GRK70.36824780
138FER0.35528689
139PRKCI0.35247675
140SGK30.34860680
141STK30.34429344
142IGF1R0.34080478
143PRKG20.33844363
144CSNK1E0.32847375
145ITK0.31749239
146PRKCQ0.29889311
147IRAK10.28801787

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.95567834
2Protein export_Homo sapiens_hsa030603.71169303
3Synaptic vesicle cycle_Homo sapiens_hsa047213.33878298
4Insulin secretion_Homo sapiens_hsa049112.86005097
5Nicotine addiction_Homo sapiens_hsa050332.78887671
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.69412670
7Butanoate metabolism_Homo sapiens_hsa006502.64609055
8Vibrio cholerae infection_Homo sapiens_hsa051102.62983309
9Collecting duct acid secretion_Homo sapiens_hsa049662.62879299
10Amphetamine addiction_Homo sapiens_hsa050312.40298009
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.22778185
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.22382360
13Circadian entrainment_Homo sapiens_hsa047132.18527279
14Taste transduction_Homo sapiens_hsa047422.13623806
15GABAergic synapse_Homo sapiens_hsa047272.06111134
16Morphine addiction_Homo sapiens_hsa050322.02660299
17Olfactory transduction_Homo sapiens_hsa047402.01978838
18Long-term potentiation_Homo sapiens_hsa047202.01961175
19Selenocompound metabolism_Homo sapiens_hsa004501.93634012
20Dopaminergic synapse_Homo sapiens_hsa047281.87578205
21Cocaine addiction_Homo sapiens_hsa050301.85836326
22Oxidative phosphorylation_Homo sapiens_hsa001901.80827235
23Linoleic acid metabolism_Homo sapiens_hsa005911.71446579
24Propanoate metabolism_Homo sapiens_hsa006401.69180289
25Glutamatergic synapse_Homo sapiens_hsa047241.65902021
26Serotonergic synapse_Homo sapiens_hsa047261.64162947
27Tryptophan metabolism_Homo sapiens_hsa003801.63452108
28Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.61676819
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.60502926
30Pancreatic secretion_Homo sapiens_hsa049721.55471366
31Fatty acid elongation_Homo sapiens_hsa000621.52726289
32Peroxisome_Homo sapiens_hsa041461.52617781
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.52405599
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.52145699
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.49325307
36Cholinergic synapse_Homo sapiens_hsa047251.48168137
37SNARE interactions in vesicular transport_Homo sapiens_hsa041301.48089356
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.45669912
39Ether lipid metabolism_Homo sapiens_hsa005651.41629399
40Renin secretion_Homo sapiens_hsa049241.38978800
41Parkinsons disease_Homo sapiens_hsa050121.37954652
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33881396
43N-Glycan biosynthesis_Homo sapiens_hsa005101.32708103
44Type II diabetes mellitus_Homo sapiens_hsa049301.31784839
45Alzheimers disease_Homo sapiens_hsa050101.31762538
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.31407458
47Circadian rhythm_Homo sapiens_hsa047101.30976094
48Salivary secretion_Homo sapiens_hsa049701.25519965
49Caffeine metabolism_Homo sapiens_hsa002321.24710443
50Retinol metabolism_Homo sapiens_hsa008301.21889071
51Chemical carcinogenesis_Homo sapiens_hsa052041.21728674
52Long-term depression_Homo sapiens_hsa047301.19470529
53beta-Alanine metabolism_Homo sapiens_hsa004101.14855109
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.12839759
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.12116443
56Calcium signaling pathway_Homo sapiens_hsa040201.10492633
57Huntingtons disease_Homo sapiens_hsa050161.09910034
58Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.08810072
59Pentose and glucuronate interconversions_Homo sapiens_hsa000401.05526387
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.05262101
61RNA polymerase_Homo sapiens_hsa030201.04571294
62Nitrogen metabolism_Homo sapiens_hsa009101.04109921
63Folate biosynthesis_Homo sapiens_hsa007901.03782386
64Arachidonic acid metabolism_Homo sapiens_hsa005901.03363307
65Gastric acid secretion_Homo sapiens_hsa049711.02888830
66Mineral absorption_Homo sapiens_hsa049781.01186077
67Fatty acid degradation_Homo sapiens_hsa000710.99755735
68Sulfur metabolism_Homo sapiens_hsa009200.99166129
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.97397486
70Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.96291223
71Glucagon signaling pathway_Homo sapiens_hsa049220.95548772
72Oxytocin signaling pathway_Homo sapiens_hsa049210.95495097
73Fat digestion and absorption_Homo sapiens_hsa049750.94694382
74ABC transporters_Homo sapiens_hsa020100.94605638
75cAMP signaling pathway_Homo sapiens_hsa040240.94590995
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.92121827
77Regulation of autophagy_Homo sapiens_hsa041400.91934846
78Proteasome_Homo sapiens_hsa030500.91663522
79Fatty acid metabolism_Homo sapiens_hsa012120.91275580
80Glutathione metabolism_Homo sapiens_hsa004800.91217319
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.90501252
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89393717
83Histidine metabolism_Homo sapiens_hsa003400.89004801
84Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88750121
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.88497484
86GnRH signaling pathway_Homo sapiens_hsa049120.88133230
87Estrogen signaling pathway_Homo sapiens_hsa049150.87834068
88Cardiac muscle contraction_Homo sapiens_hsa042600.85814123
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84263468
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84054938
91Thyroid hormone synthesis_Homo sapiens_hsa049180.81783305
92Metabolic pathways_Homo sapiens_hsa011000.81017888
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79783175
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77084254
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.76178432
96Vitamin B6 metabolism_Homo sapiens_hsa007500.76038647
97Fatty acid biosynthesis_Homo sapiens_hsa000610.75746480
98Fanconi anemia pathway_Homo sapiens_hsa034600.75507599
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.72280430
100Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72071233
101* Type I diabetes mellitus_Homo sapiens_hsa049400.71948326
102Homologous recombination_Homo sapiens_hsa034400.71430370
103Oocyte meiosis_Homo sapiens_hsa041140.71099425
104Glycerolipid metabolism_Homo sapiens_hsa005610.70982155
105Alcoholism_Homo sapiens_hsa050340.70832347
106Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70233347
107Gap junction_Homo sapiens_hsa045400.70100996
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66427053
109Rheumatoid arthritis_Homo sapiens_hsa053230.65203691
110Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62712543
111Vitamin digestion and absorption_Homo sapiens_hsa049770.62677685
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62394838
113Other glycan degradation_Homo sapiens_hsa005110.59738217
114Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59201396
115One carbon pool by folate_Homo sapiens_hsa006700.56537497
116Arginine and proline metabolism_Homo sapiens_hsa003300.55144049
117Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54210040
118Cysteine and methionine metabolism_Homo sapiens_hsa002700.53553753
119Tyrosine metabolism_Homo sapiens_hsa003500.53456621
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53024367
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50753293
122Inositol phosphate metabolism_Homo sapiens_hsa005620.49573557
123Prolactin signaling pathway_Homo sapiens_hsa049170.49373598
124Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.48162635
125Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.47787224
126Renin-angiotensin system_Homo sapiens_hsa046140.47440042
127Phagosome_Homo sapiens_hsa041450.46658928
128Melanogenesis_Homo sapiens_hsa049160.44824720
129ErbB signaling pathway_Homo sapiens_hsa040120.43416115
130Purine metabolism_Homo sapiens_hsa002300.42554179
131Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39878269
132Glioma_Homo sapiens_hsa052140.39738507
133Insulin signaling pathway_Homo sapiens_hsa049100.39386135
134Ovarian steroidogenesis_Homo sapiens_hsa049130.38976888
135Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.38648669
136Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35106841
137Phototransduction_Homo sapiens_hsa047440.34594681
138Fructose and mannose metabolism_Homo sapiens_hsa000510.34581503
139Neurotrophin signaling pathway_Homo sapiens_hsa047220.33486275
140RNA degradation_Homo sapiens_hsa030180.33330223
141Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32493882
142Galactose metabolism_Homo sapiens_hsa000520.30526206
143Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.30453729
144MAPK signaling pathway_Homo sapiens_hsa040100.29443785
145Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28140876
146Glycosaminoglycan degradation_Homo sapiens_hsa005310.27193976
147Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26460249
148Basal transcription factors_Homo sapiens_hsa030220.25916209
149Sphingolipid metabolism_Homo sapiens_hsa006000.25888228
150Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.25658356
151Lysosome_Homo sapiens_hsa041420.24587976
152Ras signaling pathway_Homo sapiens_hsa040140.22983349
153Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.21051999
154Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.20590143
155Thyroid cancer_Homo sapiens_hsa052160.19830509

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