ICAM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of vitamin D biosynthetic process (GO:0060556)5.63438290
2positive regulation by organism of defense response of other organism involved in symbiotic interact5.50525445
3modulation by symbiont of host immune response (GO:0052553)5.50525445
4positive regulation by symbiont of host defense response (GO:0052509)5.50525445
5modulation by symbiont of host defense response (GO:0052031)5.50525445
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.50525445
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.50525445
8response to peptidoglycan (GO:0032494)4.71190511
9response to muramyl dipeptide (GO:0032495)4.64449666
10antigen processing and presentation of endogenous antigen (GO:0019883)4.60534036
11NIK/NF-kappaB signaling (GO:0038061)4.56349402
12regulation of cytokine secretion involved in immune response (GO:0002739)4.55506470
13regulation of vitamin metabolic process (GO:0030656)4.47083828
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.37827771
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.37827771
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.32043950
17positive regulation of interferon-alpha production (GO:0032727)4.29167030
18regulation of interferon-alpha production (GO:0032647)4.15303175
19neutrophil activation involved in immune response (GO:0002283)4.10663383
20regulation of interleukin-12 biosynthetic process (GO:0045075)4.06865433
21macrophage activation involved in immune response (GO:0002281)3.98900412
22positive regulation of gamma-delta T cell activation (GO:0046645)3.95917933
23regulation of mononuclear cell migration (GO:0071675)3.89125285
24regulation of dendritic cell antigen processing and presentation (GO:0002604)3.86071654
25lipopolysaccharide-mediated signaling pathway (GO:0031663)3.86016694
26immunoglobulin mediated immune response (GO:0016064)3.85701576
27positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.80563730
28type I interferon signaling pathway (GO:0060337)3.78119152
29cellular response to type I interferon (GO:0071357)3.78119152
30response to type I interferon (GO:0034340)3.78035295
31positive regulation of antigen processing and presentation (GO:0002579)3.77220338
32branching involved in labyrinthine layer morphogenesis (GO:0060670)3.73405452
33response to host immune response (GO:0052572)3.72519119
34response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.72519119
35positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.67909290
36myeloid dendritic cell differentiation (GO:0043011)3.66357228
37positive regulation of interleukin-12 production (GO:0032735)3.64832780
38regulation of membrane protein ectodomain proteolysis (GO:0051043)3.63603337
39response to protozoan (GO:0001562)3.62979141
40negative regulation of cytokine production involved in immune response (GO:0002719)3.60328500
41negative regulation of nitric oxide biosynthetic process (GO:0045019)3.60186932
42regulation of interferon-beta biosynthetic process (GO:0045357)3.56645419
43regulation of T-helper 1 cell differentiation (GO:0045625)3.56642686
44positive regulation of chemokine biosynthetic process (GO:0045080)3.52739530
45negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.51008101
46positive regulation of interferon-beta production (GO:0032728)3.41526059
47response to host defenses (GO:0052200)3.39158869
48response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.39158869
49response to host (GO:0075136)3.39158869
50microglial cell activation (GO:0001774)3.35735639
51regulation of immunoglobulin secretion (GO:0051023)3.35156408
52germinal center formation (GO:0002467)3.33800989
53activation of MAPKKK activity (GO:0000185)3.32198039
54positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.32175537
55myeloid dendritic cell activation (GO:0001773)3.30999034
56regulation of heat generation (GO:0031650)3.30487137
57natural killer cell mediated immunity (GO:0002228)3.29945322
58natural killer cell mediated cytotoxicity (GO:0042267)3.29945322
59* interferon-gamma-mediated signaling pathway (GO:0060333)3.28370759
60glycosphingolipid catabolic process (GO:0046479)3.25221871
61T-helper 1 type immune response (GO:0042088)3.25095512
62positive regulation of heat generation (GO:0031652)3.23328743
63regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.23086494
64regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.21039594
65oligosaccharide catabolic process (GO:0009313)3.20983192
66granulocyte activation (GO:0036230)3.17920537
67regulation of antigen processing and presentation (GO:0002577)3.17131163
68positive regulation of cellular amide metabolic process (GO:0034250)3.16375438
69regulation of T-helper 2 cell differentiation (GO:0045628)3.15319031
70positive regulation of humoral immune response (GO:0002922)3.14241499
71negative regulation of myeloid cell apoptotic process (GO:0033033)3.14169100
72positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.13631713
73response to interferon-alpha (GO:0035455)3.13358214
74detection of molecule of bacterial origin (GO:0032490)3.11494723
75regulation of interleukin-8 biosynthetic process (GO:0045414)3.10566630
76* cellular response to lipopolysaccharide (GO:0071222)3.10074029
77neutrophil activation (GO:0042119)3.08463536
78regulation of interleukin-12 production (GO:0032655)3.07623712
79positive regulation of acute inflammatory response (GO:0002675)3.07618242
80negative regulation of interleukin-12 production (GO:0032695)3.04235084
81regulation of fever generation (GO:0031620)3.02637958
82cellular response to virus (GO:0098586)3.00719064
83I-kappaB phosphorylation (GO:0007252)2.99242651
84* cellular response to molecule of bacterial origin (GO:0071219)2.99238729
85regulation of podosome assembly (GO:0071801)2.98993934
86positive regulation of interleukin-6 production (GO:0032755)2.98988999
87* regulation of nitric oxide biosynthetic process (GO:0045428)2.97302334
88B cell mediated immunity (GO:0019724)2.96828287
89JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.96411315
90cellular response to thyroid hormone stimulus (GO:0097067)2.94810181
91negative regulation of interleukin-17 production (GO:0032700)2.93969383
92dendritic cell differentiation (GO:0097028)2.92905028
93negative regulation of lipid storage (GO:0010888)2.92720684
94response to interferon-beta (GO:0035456)2.92037794
95macrophage activation (GO:0042116)2.91049361
96negative regulation of viral genome replication (GO:0045071)2.90010475
97positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.89887627
98negative regulation of production of molecular mediator of immune response (GO:0002701)2.89885894
99cellular response to interferon-beta (GO:0035458)2.89821561
100glycolipid catabolic process (GO:0019377)2.89420436
101regulation of NF-kappaB import into nucleus (GO:0042345)2.88527965
102modulation by symbiont of host cellular process (GO:0044068)2.87948855
103cytokine secretion (GO:0050663)2.87875061
104regulation of chemokine biosynthetic process (GO:0045073)2.87862304
105regulation of heterotypic cell-cell adhesion (GO:0034114)2.87278725
106regulation of type 2 immune response (GO:0002828)2.86569583
107negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.86340305
108regulation of T-helper cell differentiation (GO:0045622)2.85172896
109positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.84813536
110regulation of gamma-delta T cell activation (GO:0046643)2.84134239
111regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.82135065
112positive regulation of type 2 immune response (GO:0002830)2.82103187
113regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.81896178
114regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.79330843
115positive regulation of T-helper cell differentiation (GO:0045624)2.79306057
116regulation of integrin activation (GO:0033623)2.79283620
117myeloid cell activation involved in immune response (GO:0002275)2.79064793
118defense response to protozoan (GO:0042832)2.78671106
119positive regulation of macrophage cytokine production (GO:0060907)2.77038242
120regulation of cholesterol storage (GO:0010885)2.76728762
121respiratory burst (GO:0045730)2.76132213
122regulation of inflammatory response to antigenic stimulus (GO:0002861)2.75796709
123* cellular response to interferon-gamma (GO:0071346)2.75365963
124* positive regulation of nitric oxide biosynthetic process (GO:0045429)2.74784370
125positive regulation of NF-kappaB import into nucleus (GO:0042346)2.72047657
126wound healing, spreading of epidermal cells (GO:0035313)2.72024201
127regulation of chronic inflammatory response (GO:0002676)2.71829623
128negative regulation of growth of symbiont in host (GO:0044130)2.71775012
129negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.71775012
130modulation of growth of symbiont involved in interaction with host (GO:0044144)2.71775012
131regulation of growth of symbiont in host (GO:0044126)2.71775012
132positive regulation of toll-like receptor signaling pathway (GO:0034123)2.71160921
133positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.70925566
134positive regulation of natural killer cell differentiation (GO:0032825)2.70353401
135positive regulation of p38MAPK cascade (GO:1900745)2.70273533
136low-density lipoprotein particle clearance (GO:0034383)2.69788018
137positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.69785327
138leukocyte mediated cytotoxicity (GO:0001909)2.69731148
139cellular response to nicotine (GO:0071316)2.69488949
140positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.68263221
141regulation of interleukin-17 production (GO:0032660)2.68139388
142monocyte chemotaxis (GO:0002548)2.67341201
143regulation of type I interferon-mediated signaling pathway (GO:0060338)2.65435867
144positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.64638193
145hydrogen peroxide biosynthetic process (GO:0050665)2.64617156

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.16834844
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.82896543
3IRF8_21731497_ChIP-ChIP_J774_Mouse5.61272517
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.10711183
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.84495213
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.74256329
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.68931827
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.67726608
9TP63_17297297_ChIP-ChIP_HaCaT_Human3.56035172
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.51794486
11* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.49916064
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.45282002
13* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.13271511
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.13106309
15Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.97530067
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.91018422
17* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.73500638
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.71287494
19* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.65150158
20* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.40102953
21* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.16251904
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.06973661
23GATA1_22025678_ChIP-Seq_K562_Human2.02290123
24GATA2_21666600_ChIP-Seq_HMVEC_Human1.98083300
25BRD4_27068464_Chip-Seq_AML-cells_Mouse1.89818859
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.88100964
27RUNX_20019798_ChIP-Seq_JUKART_Human1.84008021
28STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.80031212
29MAF_26560356_Chip-Seq_TH1_Human1.73510388
30PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.69587098
31SCL_19346495_ChIP-Seq_HPC-7_Human1.66047854
32VDR_24763502_ChIP-Seq_THP-1_Human1.64035899
33MYB_26560356_Chip-Seq_TH2_Human1.64001783
34* SPI1_23547873_ChIP-Seq_NB4_Human1.60800684
35TRIM28_21343339_ChIP-Seq_HEK293_Human1.59448388
36VDR_24787735_ChIP-Seq_THP-1_Human1.56738068
37* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.51585287
38* SPI1_23127762_ChIP-Seq_K562_Human1.51059912
39ELK3_25401928_ChIP-Seq_HUVEC_Human1.50612809
40PU_27001747_Chip-Seq_BMDM_Mouse1.43012129
41MYB_26560356_Chip-Seq_TH1_Human1.42660368
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.41592353
43SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.41160875
44LXR_22292898_ChIP-Seq_THP-1_Human1.40223639
45TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39073211
46RUNX1_22412390_ChIP-Seq_EML_Mouse1.38674723
47VDR_21846776_ChIP-Seq_THP-1_Human1.37515416
48PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36282398
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.32857454
50ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.31965953
51CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31071232
52CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30131870
53RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.29482089
54TCF7_22412390_ChIP-Seq_EML_Mouse1.27222510
55NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.27009729
56FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.25347886
57SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.24331740
58SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.24331740
59KDM2B_26808549_Chip-Seq_SUP-B15_Human1.23460289
60ESR1_21235772_ChIP-Seq_MCF-7_Human1.21619791
61LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.19355948
62STAT6_21828071_ChIP-Seq_BEAS2B_Human1.18784257
63* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.17931491
64RARG_19884340_ChIP-ChIP_MEFs_Mouse1.17127153
65TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.16378823
66PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.15975245
67GATA3_27048872_Chip-Seq_THYMUS_Human1.14303504
68CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.10781627
69UTX_26944678_Chip-Seq_JUKART_Human1.08743199
70RXR_22158963_ChIP-Seq_LIVER_Mouse1.08671971
71ESR2_21235772_ChIP-Seq_MCF-7_Human1.06567004
72VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06337118
73FOXO3_23340844_ChIP-Seq_DLD1_Human1.05980942
74* GATA1_19941827_ChIP-Seq_MEL_Mouse1.03533101
75CLOCK_20551151_ChIP-Seq_293T_Human1.01096737
76KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.00732806
77KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.00732806
78KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.00732806
79SOX2_20726797_ChIP-Seq_SW620_Human0.99580230
80HIF1A_21447827_ChIP-Seq_MCF-7_Human0.99002109
81GATA2_22383799_ChIP-Seq_G1ME_Mouse0.98755227
82CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97650456
83GATA3_26560356_Chip-Seq_TH2_Human0.97110075
84* MYC_22102868_ChIP-Seq_BL_Human0.96576454
85MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.96427017
86CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95118741
87KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.93831584
88ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.93512596
89LXR_22158963_ChIP-Seq_LIVER_Mouse0.93131859
90JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93011711
91RACK7_27058665_Chip-Seq_MCF-7_Human0.92430077
92TFEB_21752829_ChIP-Seq_HELA_Human0.92213892
93PPARA_22158963_ChIP-Seq_LIVER_Mouse0.91704833
94STAT1_20625510_ChIP-Seq_HELA_Human0.90108493
95ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.89241297
96* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.87794630
97PPAR_26484153_Chip-Seq_NCI-H1993_Human0.87666602
98UBF1/2_26484160_Chip-Seq_HMECs_Human0.87094339
99KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.86976216
100KDM2B_26808549_Chip-Seq_DND41_Human0.86622295
101NFIB_24661679_ChIP-Seq_LUNG_Mouse0.86489046
102FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.86315260
103KDM2B_26808549_Chip-Seq_K562_Human0.85911309
104PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85866684
105SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.85670320
106* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.85570898
107JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85309907
108LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.85268357
109MAF_26560356_Chip-Seq_TH2_Human0.84330757
110GATA1_19941826_ChIP-Seq_K562_Human0.84308339
111PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84203095
112RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.82346081
113KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.82205180
114SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82043581
115CJUN_26792858_Chip-Seq_BT549_Human0.82031598
116TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.81042843
117* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.80742869
118GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.79997713
119CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.79243785
120P63_26484246_Chip-Seq_KERATINOCYTES_Human0.78800427

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.03895119
2MP0003724_increased_susceptibility_to3.39041850
3MP0003436_decreased_susceptibility_to3.38807427
4MP0003303_peritoneal_inflammation3.37147320
5* MP0009785_altered_susceptibility_to3.29402390
6MP0000685_abnormal_immune_system3.16965351
7MP0002254_reproductive_system_inflammat2.83416600
8MP0004510_myositis2.83290262
9* MP0002148_abnormal_hypersensitivity_rea2.83210715
10* MP0005000_abnormal_immune_tolerance2.72985326
11* MP0005387_immune_system_phenotype2.68620083
12* MP0001790_abnormal_immune_system2.68620083
13MP0002419_abnormal_innate_immunity2.65949127
14* MP0005025_abnormal_response_to2.60172364
15MP0006082_CNS_inflammation2.59371216
16MP0002139_abnormal_hepatobiliary_system2.53252770
17MP0005671_abnormal_response_to2.46835995
18MP0001800_abnormal_humoral_immune2.41035192
19MP0002452_abnormal_antigen_presenting2.39064776
20MP0005451_abnormal_body_composition2.33009172
21MP0002723_abnormal_immune_serum2.29972303
22MP0009278_abnormal_bone_marrow2.24599803
23MP0002138_abnormal_hepatobiliary_system2.16185484
24MP0004947_skin_inflammation2.14899559
25MP0001819_abnormal_immune_cell2.01617653
26MP0002420_abnormal_adaptive_immunity1.98618056
27MP0005167_abnormal_blood-brain_barrier1.96306362
28MP0002405_respiratory_system_inflammati1.93154880
29MP0001533_abnormal_skeleton_physiology1.90824859
30MP0004782_abnormal_surfactant_physiolog1.89600466
31MP0006054_spinal_hemorrhage1.88675562
32* MP0003448_altered_tumor_morphology1.82390821
33MP0001853_heart_inflammation1.82097988
34MP0003300_gastrointestinal_ulcer1.79391660
35MP0009764_decreased_sensitivity_to1.77905324
36MP0005397_hematopoietic_system_phenotyp1.77182676
37MP0001545_abnormal_hematopoietic_system1.77182676
38MP0005058_abnormal_lysosome_morphology1.75535120
39MP0005464_abnormal_platelet_physiology1.71226384
40* MP0010155_abnormal_intestine_physiology1.69809212
41MP0000343_altered_response_to1.69568771
42* MP0001845_abnormal_inflammatory_respons1.67982516
43MP0002006_tumorigenesis1.55972876
44MP0008469_abnormal_protein_level1.48958775
45MP0002166_altered_tumor_susceptibility1.48865500
46MP0003828_pulmonary_edema1.47672339
47* MP0000716_abnormal_immune_system1.46224427
48MP0005310_abnormal_salivary_gland1.44532601
49MP0001851_eye_inflammation1.43688986
50MP0003566_abnormal_cell_adhesion1.40613082
51MP0001958_emphysema1.38879393
52* MP0002398_abnormal_bone_marrow1.38272159
53MP0003075_altered_response_to1.37618480
54MP0001879_abnormal_lymphatic_vessel1.35333904
55MP0003172_abnormal_lysosome_physiology1.35178962
56MP0003195_calcinosis1.35149602
57MP0003690_abnormal_glial_cell1.34877881
58MP0003806_abnormal_nucleotide_metabolis1.33087980
59MP0000858_altered_metastatic_potential1.32814628
60MP0005076_abnormal_cell_differentiation1.30028085
61MP0009333_abnormal_splenocyte_physiolog1.28145590
62MP0003191_abnormal_cellular_cholesterol1.27694069
63MP0003656_abnormal_erythrocyte_physiolo1.21280296
64MP0002277_abnormal_respiratory_mucosa1.21275443
65MP0009840_abnormal_foam_cell1.21122212
66MP0001873_stomach_inflammation1.20475533
67MP0002998_abnormal_bone_remodeling1.19990988
68MP0010352_gastrointestinal_tract_polyps1.18774061
69MP0005164_abnormal_response_to1.18655841
70MP0000689_abnormal_spleen_morphology1.18033689
71* MP0002429_abnormal_blood_cell1.17420747
72MP0001542_abnormal_bone_strength1.17342240
73MP0010307_abnormal_tumor_latency1.11973695
74MP0002722_abnormal_immune_system1.11143092
75MP0000604_amyloidosis1.08655963
76* MP0003453_abnormal_keratinocyte_physiol1.08412658
77MP0000569_abnormal_digit_pigmentation1.07209053
78MP0005165_increased_susceptibility_to1.05484173
79MP0000767_abnormal_smooth_muscle1.05144805
80MP0003763_abnormal_thymus_physiology1.05031714
81* MP0003091_abnormal_cell_migration1.04502927
82MP0005166_decreased_susceptibility_to1.01487692
83MP0010368_abnormal_lymphatic_system0.97761608
84* MP0000249_abnormal_blood_vessel0.97037483
85MP0005390_skeleton_phenotype0.96751045
86MP0009763_increased_sensitivity_to0.94778732
87MP0004808_abnormal_hematopoietic_stem0.92287342
88MP0002877_abnormal_melanocyte_morpholog0.87352409
89MP0000920_abnormal_myelination0.86809335
90MP0003705_abnormal_hypodermis_morpholog0.85248126
91* MP0005023_abnormal_wound_healing0.84305928
92MP0004883_abnormal_blood_vessel0.84165532
93MP0003950_abnormal_plasma_membrane0.82024775
94MP0009765_abnormal_xenobiotic_induced0.81913401
95MP0003329_amyloid_beta_deposits0.79819364
96MP0001663_abnormal_digestive_system0.79625596
97MP0001348_abnormal_lacrimal_gland0.76974932
98MP0005083_abnormal_biliary_tract0.76443984
99MP0008874_decreased_physiological_sensi0.75832822
100MP0005647_abnormal_sex_gland0.75611224
101MP0002933_joint_inflammation0.75004757
102MP0000465_gastrointestinal_hemorrhage0.74534181
103MP0001501_abnormal_sleep_pattern0.73502255
104MP0002136_abnormal_kidney_physiology0.73186185
105MP0008004_abnormal_stomach_pH0.70274953
106MP0003795_abnormal_bone_structure0.69601742
107MP0000703_abnormal_thymus_morphology0.68498525
108MP0008260_abnormal_autophagy0.67548349
109MP0003183_abnormal_peptide_metabolism0.63740623
110MP0005257_abnormal_intraocular_pressure0.63721020
111MP0000371_diluted_coat_color0.62984068
112MP0003279_aneurysm0.62813213
113MP0005595_abnormal_vascular_smooth0.61998875
114MP0001346_abnormal_lacrimal_gland0.61707259
115MP0002133_abnormal_respiratory_system0.60959438
116MP0005388_respiratory_system_phenotype0.60959438
117MP0003646_muscle_fatigue0.59773645
118MP0000627_abnormal_mammary_gland0.59339097
119MP0000609_abnormal_liver_physiology0.59227015
120MP0000490_abnormal_crypts_of0.59013516
121MP0004858_abnormal_nervous_system0.58785402
122MP0002332_abnormal_exercise_endurance0.58591075
123MP0002295_abnormal_pulmonary_circulatio0.58182384
124MP0001881_abnormal_mammary_gland0.57997535
125MP0005535_abnormal_body_temperature0.55821786

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.87214786
2Recurrent abscess formation (HP:0002722)5.77507442
3Recurrent bacterial skin infections (HP:0005406)5.28969610
4Elevated erythrocyte sedimentation rate (HP:0003565)5.26125002
5Interstitial pulmonary disease (HP:0006530)4.87586857
6Myositis (HP:0100614)4.68060707
7Orchitis (HP:0100796)4.60527536
8Recurrent gram-negative bacterial infections (HP:0005420)4.54942572
9Abnormality of macrophages (HP:0004311)4.53828108
10Mediastinal lymphadenopathy (HP:0100721)4.44508408
11Hematochezia (HP:0002573)4.44128089
12Retrobulbar optic neuritis (HP:0100654)4.35177462
13Optic neuritis (HP:0100653)4.35177462
14Disinhibition (HP:0000734)4.17758148
15Stomatitis (HP:0010280)4.01978433
16Nuclear cataract (HP:0100018)3.73497709
17Autoimmune thrombocytopenia (HP:0001973)3.69527126
18Chronic otitis media (HP:0000389)3.65748636
19Recurrent fungal infections (HP:0002841)3.62326137
20Abnormality of the nasal mucosa (HP:0000433)3.60103305
21Vasculitis (HP:0002633)3.57087656
22Recurrent skin infections (HP:0001581)3.51243901
23Neurofibrillary tangles (HP:0002185)3.49105543
24Mutism (HP:0002300)3.47907917
25Thick nail (HP:0001805)3.35504176
26Pustule (HP:0200039)3.32087304
27Colitis (HP:0002583)3.31250863
28Gingivitis (HP:0000230)3.28620538
29Pulmonary infiltrates (HP:0002113)3.24456359
30Increased cerebral lipofuscin (HP:0011813)3.23243581
31Increased IgM level (HP:0003496)3.21424866
32Tetraparesis (HP:0002273)3.17194317
33Vacuolated lymphocytes (HP:0001922)3.12117765
34Recurrent viral infections (HP:0004429)3.12100200
35Systemic lupus erythematosus (HP:0002725)3.09113101
36Spontaneous hematomas (HP:0007420)3.01415624
37Increased neuronal autofluorescent lipopigment (HP:0002074)2.98183025
38Complement deficiency (HP:0004431)2.96298946
39Keratoconjunctivitis (HP:0001096)2.95314724
40Nasal polyposis (HP:0100582)2.91049363
41Arterial thrombosis (HP:0004420)2.89934935
42Apathy (HP:0000741)2.89895696
43Recurrent cutaneous fungal infections (HP:0011370)2.87952617
44Chronic mucocutaneous candidiasis (HP:0002728)2.87952617
45Esophageal varix (HP:0002040)2.85764389
46Increased serum ferritin (HP:0003281)2.79995087
47Basal ganglia calcification (HP:0002135)2.77979983
48Diminished motivation (HP:0000745)2.77604151
49Periodontitis (HP:0000704)2.76810092
50Hemoptysis (HP:0002105)2.73170348
51Keratoconjunctivitis sicca (HP:0001097)2.72546539
52Leukocytosis (HP:0001974)2.67316594
53Prostate neoplasm (HP:0100787)2.65973494
54Inflammation of the large intestine (HP:0002037)2.61374771
55Gangrene (HP:0100758)2.60596812
56Cellulitis (HP:0100658)2.59338776
57Purpura (HP:0000979)2.56720762
58Cerebral inclusion bodies (HP:0100314)2.55443601
59Amyloidosis (HP:0011034)2.54620865
60Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.52442256
61Polycythemia (HP:0001901)2.52200429
62Abnormality of complement system (HP:0005339)2.51617455
63Progressive neurologic deterioration (HP:0002344)2.50370782
64Hypergammaglobulinemia (HP:0010702)2.48685351
65Chronic obstructive pulmonary disease (HP:0006510)2.47374829
66Obstructive lung disease (HP:0006536)2.47374829
67Urticaria (HP:0001025)2.46103923
68Gastrointestinal infarctions (HP:0005244)2.45639459
69Parakeratosis (HP:0001036)2.44522259
70Gastrointestinal inflammation (HP:0004386)2.43180467
71Myocardial infarction (HP:0001658)2.41850329
72Neuronal loss in central nervous system (HP:0002529)2.39530426
73Osteomyelitis (HP:0002754)2.38068349
74Premature loss of primary teeth (HP:0006323)2.36833609
75Axonal loss (HP:0003447)2.36509726
76Porencephaly (HP:0002132)2.34996467
77Osteolytic defects of the hand bones (HP:0009699)2.33790158
78Osteolytic defects of the phalanges of the hand (HP:0009771)2.33790158
79Recurrent bronchitis (HP:0002837)2.33276848
80Abnormality of the vasculature of the conjunctiva (HP:0008054)2.31008358
81Inappropriate behavior (HP:0000719)2.24791601
82Gingival bleeding (HP:0000225)2.24451077
83Metaphyseal irregularity (HP:0003025)2.23689481
84Meningitis (HP:0001287)2.23552633
85Loss of speech (HP:0002371)2.16865200
86Emphysema (HP:0002097)2.16727473
87Abnormality of iron homeostasis (HP:0011031)2.13383327
88Eosinophilia (HP:0001880)2.12468689
89Nausea (HP:0002018)2.12009881
90Increased IgE level (HP:0003212)2.11251126
91Glomerulonephritis (HP:0000099)2.09920403
92Prolonged neonatal jaundice (HP:0006579)2.09273966
93Dysostosis multiplex (HP:0000943)2.09229332
94Vertebral compression fractures (HP:0002953)2.08887668
95Skin ulcer (HP:0200042)2.07755065
96Hepatosplenomegaly (HP:0001433)2.06719331
97Abnormality of the pleura (HP:0002103)2.02135325
98Upper motor neuron abnormality (HP:0002127)2.01837959
99Conjunctival telangiectasia (HP:0000524)2.01555782
100Autoimmune hemolytic anemia (HP:0001890)2.01266816
101Personality changes (HP:0000751)2.00652493
102Asymmetric septal hypertrophy (HP:0001670)1.99274435
103Anorexia (HP:0002039)1.98966897
104Agnosia (HP:0010524)1.97102423
105Petechiae (HP:0000967)1.95576369
106Urinary glycosaminoglycan excretion (HP:0003541)1.94476587
107Mucopolysacchariduria (HP:0008155)1.94476587
108Nephritis (HP:0000123)1.94066411
109Abnormality of liposaccharide metabolism (HP:0010968)1.93001693
110Abnormality of glycosphingolipid metabolism (HP:0004343)1.93001693
111Abnormality of glycolipid metabolism (HP:0010969)1.93001693
112Pulmonary embolism (HP:0002204)1.92778266
113Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.92591652
114Recurrent pneumonia (HP:0006532)1.92385906
115Polyneuropathy (HP:0001271)1.91030434
116Abnormal delayed hypersensitivity skin test (HP:0002963)1.90687506
117Thrombocytosis (HP:0001894)1.89805070
118Bone pain (HP:0002653)1.89572175
119Arthralgia (HP:0002829)1.89567710
120Acne (HP:0001061)1.89303090
121Joint swelling (HP:0001386)1.88934039
122Dementia (HP:0000726)1.88805567
123Gastrointestinal stroma tumor (HP:0100723)1.88740797
124Memory impairment (HP:0002354)1.88373846
125Abnormality of the pericardium (HP:0001697)1.87556609
126Stomach cancer (HP:0012126)1.87445222
127Malnutrition (HP:0004395)1.87102230
128Restrictive lung disease (HP:0002091)1.86408149
129Encephalitis (HP:0002383)1.85828836
130Epistaxis (HP:0000421)1.85802950
131Chronic sinusitis (HP:0011109)1.85518402
132Glomerulopathy (HP:0100820)1.84110625
133IgA deficiency (HP:0002720)1.83947262
134Abnormality of polysaccharide metabolism (HP:0011012)1.83452746
135Abnormality of glycosaminoglycan metabolism (HP:0004371)1.83452746
136Abnormality of mucopolysaccharide metabolism (HP:0011020)1.83452746
137Hydroxyprolinuria (HP:0003080)1.83231494
138Segmental peripheral demyelination/remyelination (HP:0003481)1.82464722
139Peripheral demyelination (HP:0011096)1.82260853

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K145.34618402
2TBK14.02279732
3TYK23.42372922
4IKBKE3.27166973
5IRAK33.16533979
6TAOK23.13905971
7DDR22.98700502
8IKBKB2.84846874
9JAK32.66950783
10TGFBR22.54532112
11RIPK42.50221256
12IRAK42.46091480
13MAP4K12.27652200
14PRPF4B2.23684403
15CHUK2.18070477
16JAK12.16775729
17TAOK12.08210248
18ERN12.00614018
19EPHB11.97802890
20KIT1.96011437
21BLK1.95309669
22PIM21.89718190
23MAP3K131.80340479
24TIE11.79956106
25TXK1.74025061
26FGFR41.60429121
27CDC42BPA1.58237568
28CSK1.56332347
29RIPK11.48159633
30ZAP701.43191905
31MAP3K31.37996938
32RPS6KA41.33551324
33KDR1.31198146
34STK101.30343828
35EPHA31.28170555
36MST41.24672187
37PIM11.21966059
38ADRBK21.17932852
39FGFR31.17813227
40TGFBR11.08951742
41JAK21.08519931
42HCK1.07966430
43IRAK21.07177091
44MATK1.04651753
45PTK61.03871055
46CSF1R1.01446131
47LATS20.98884557
48LCK0.97782225
49MAP2K30.97661781
50MARK30.96791371
51BTK0.95452059
52SYK0.94399550
53EIF2AK20.93483353
54BMX0.92101524
55FGR0.90496120
56NEK90.89409313
57LRRK20.89341205
58PDGFRA0.84549267
59TEC0.84545172
60TAOK30.82545549
61PBK0.77896891
62CDK120.77001273
63ARAF0.76047101
64MAP3K100.75965731
65TYRO30.75750212
66ITK0.75191825
67PAK40.74715239
68LYN0.74550980
69EGFR0.73678026
70EPHA20.73609711
71TESK10.64685459
72NLK0.64466037
73ABL10.64131900
74MAP3K110.62213160
75TESK20.60843886
76TTN0.60391325
77BMPR20.60343637
78ICK0.60319800
79SIK30.59138702
80FES0.58038654
81CDK60.57937409
82IRAK10.57857755
83ACVR1B0.57439654
84NME20.56716304
85HIPK20.54974419
86PDGFRB0.54828902
87MAP3K50.52696201
88MAPK40.52674017
89GSK3A0.52564317
90PRKCD0.52000674
91ABL20.51550252
92MAP2K60.49855329
93MAPKAPK20.49756212
94STK30.49115250
95STK40.45796877
96CLK10.42592371
97SIK20.41835641
98SIK10.41154390
99PKN10.40733842
100DAPK30.39372606
101PRKG20.37852113
102MAP3K10.37288032
103MOS0.36181016
104MAPK70.35571775
105DYRK30.35564504
106MST1R0.33605267
107PDPK10.30223283
108DYRK1B0.29249745
109RPS6KC10.28982061
110RPS6KL10.28982061
111STK240.28775620
112RPS6KA60.28770156
113DAPK20.28291363
114GRK70.28249658
115INSR0.27331534
116MAPK150.27306895
117TRIB30.26247943
118PRKCQ0.25719929
119NUAK10.25638768
120RPS6KA50.25564867
121TRPM70.25518023
122PDK10.25458324
123PTK2B0.24829306
124MAP2K20.24476546
125CAMK1D0.23735710
126IGF1R0.23313090
127MAP3K80.22311664
128GRK60.22175474
129RPS6KA20.20086396
130CAMKK20.18821423

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.27929958
2* NF-kappa B signaling pathway_Homo sapiens_hsa040642.92194796
3Toll-like receptor signaling pathway_Homo sapiens_hsa046202.73731680
4Graft-versus-host disease_Homo sapiens_hsa053322.70795031
5Allograft rejection_Homo sapiens_hsa053302.69633476
6NOD-like receptor signaling pathway_Homo sapiens_hsa046212.58324098
7Osteoclast differentiation_Homo sapiens_hsa043802.46579244
8Legionellosis_Homo sapiens_hsa051342.38714407
9RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.34209706
10* Malaria_Homo sapiens_hsa051442.32181383
11Pertussis_Homo sapiens_hsa051332.29776840
12* TNF signaling pathway_Homo sapiens_hsa046682.27317820
13Measles_Homo sapiens_hsa051622.21805259
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.16057560
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.11531081
16Toxoplasmosis_Homo sapiens_hsa051451.98024122
17* Staphylococcus aureus infection_Homo sapiens_hsa051501.88501401
18* Influenza A_Homo sapiens_hsa051641.88488329
19Tuberculosis_Homo sapiens_hsa051521.88460974
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.82474257
21Asthma_Homo sapiens_hsa053101.80147601
22B cell receptor signaling pathway_Homo sapiens_hsa046621.76821741
23Antigen processing and presentation_Homo sapiens_hsa046121.74645380
24Herpes simplex infection_Homo sapiens_hsa051681.67764589
25Apoptosis_Homo sapiens_hsa042101.67086176
26* Rheumatoid arthritis_Homo sapiens_hsa053231.62818839
27Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.54764673
28Type I diabetes mellitus_Homo sapiens_hsa049401.53559703
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.50834176
30* African trypanosomiasis_Homo sapiens_hsa051431.50202088
31Hematopoietic cell lineage_Homo sapiens_hsa046401.50074307
32Shigellosis_Homo sapiens_hsa051311.48042515
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.42957027
34Salmonella infection_Homo sapiens_hsa051321.38734656
35Hepatitis C_Homo sapiens_hsa051601.35433783
36Lysosome_Homo sapiens_hsa041421.31368712
37* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.30323828
38Primary immunodeficiency_Homo sapiens_hsa053401.26005458
39Phagosome_Homo sapiens_hsa041451.25536621
40Chemokine signaling pathway_Homo sapiens_hsa040621.25043721
41Hepatitis B_Homo sapiens_hsa051611.22180381
42Autoimmune thyroid disease_Homo sapiens_hsa053201.17304363
43* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.13920916
44Bladder cancer_Homo sapiens_hsa052191.13809107
45Small cell lung cancer_Homo sapiens_hsa052221.12677086
46Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.12542407
47Amoebiasis_Homo sapiens_hsa051461.12253274
48T cell receptor signaling pathway_Homo sapiens_hsa046601.07369760
49* Leukocyte transendothelial migration_Homo sapiens_hsa046701.04438178
50Glycosaminoglycan degradation_Homo sapiens_hsa005311.01984476
51Acute myeloid leukemia_Homo sapiens_hsa052210.96882918
52Chronic myeloid leukemia_Homo sapiens_hsa052200.91963511
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91948822
54Prolactin signaling pathway_Homo sapiens_hsa049170.86577356
55Adipocytokine signaling pathway_Homo sapiens_hsa049200.86323741
56* Viral myocarditis_Homo sapiens_hsa054160.85599343
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.85284363
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84684672
59Other glycan degradation_Homo sapiens_hsa005110.83156884
60Sphingolipid metabolism_Homo sapiens_hsa006000.81763738
61Pancreatic cancer_Homo sapiens_hsa052120.76206471
62* Epstein-Barr virus infection_Homo sapiens_hsa051690.72934702
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69703805
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68872718
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.67080903
66Complement and coagulation cascades_Homo sapiens_hsa046100.61524956
67Viral carcinogenesis_Homo sapiens_hsa052030.61504296
68Notch signaling pathway_Homo sapiens_hsa043300.61127004
69Platelet activation_Homo sapiens_hsa046110.60884098
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60191927
71Proteoglycans in cancer_Homo sapiens_hsa052050.59662432
72MicroRNAs in cancer_Homo sapiens_hsa052060.58594786
73HIF-1 signaling pathway_Homo sapiens_hsa040660.58055340
74* HTLV-I infection_Homo sapiens_hsa051660.55689275
75Caffeine metabolism_Homo sapiens_hsa002320.54968169
76Collecting duct acid secretion_Homo sapiens_hsa049660.52799774
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.52520545
78Adherens junction_Homo sapiens_hsa045200.52030687
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50864032
80VEGF signaling pathway_Homo sapiens_hsa043700.50739724
81Insulin resistance_Homo sapiens_hsa049310.50656573
82Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49600277
83Prion diseases_Homo sapiens_hsa050200.49404522
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.49316454
85Focal adhesion_Homo sapiens_hsa045100.48842182
86Sulfur metabolism_Homo sapiens_hsa009200.48450423
87Vibrio cholerae infection_Homo sapiens_hsa051100.46378942
88Galactose metabolism_Homo sapiens_hsa000520.45211258
89Systemic lupus erythematosus_Homo sapiens_hsa053220.44982162
90p53 signaling pathway_Homo sapiens_hsa041150.44837793
91Type II diabetes mellitus_Homo sapiens_hsa049300.44504181
92* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44217935
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.43321634
94ECM-receptor interaction_Homo sapiens_hsa045120.41095755
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38819865
96Dorso-ventral axis formation_Homo sapiens_hsa043200.37103820
97Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.36795675
98Prostate cancer_Homo sapiens_hsa052150.36775752
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33978218
100FoxO signaling pathway_Homo sapiens_hsa040680.33899632
101Renal cell carcinoma_Homo sapiens_hsa052110.33778601
102Fructose and mannose metabolism_Homo sapiens_hsa000510.31743600
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31197975
104Pathways in cancer_Homo sapiens_hsa052000.29949991
105MAPK signaling pathway_Homo sapiens_hsa040100.29911813
106Endocytosis_Homo sapiens_hsa041440.28974190
107PPAR signaling pathway_Homo sapiens_hsa033200.27838385
108PI3K-Akt signaling pathway_Homo sapiens_hsa041510.24030534
109Mineral absorption_Homo sapiens_hsa049780.23116753
110Rap1 signaling pathway_Homo sapiens_hsa040150.21799745
111mTOR signaling pathway_Homo sapiens_hsa041500.19136023
112TGF-beta signaling pathway_Homo sapiens_hsa043500.17304398
113Renin-angiotensin system_Homo sapiens_hsa046140.15291765
114Tryptophan metabolism_Homo sapiens_hsa003800.14357727
115Primary bile acid biosynthesis_Homo sapiens_hsa001200.12094410

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