ICAM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Several transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.83081076
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.56167200
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.56167200
4positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.87893950
5antigen processing and presentation of endogenous antigen (GO:0019883)4.82650828
6positive regulation of gamma-delta T cell activation (GO:0046645)4.66860225
7positive regulation of vasculogenesis (GO:2001214)4.48774633
8morphogenesis of an endothelium (GO:0003159)4.44369341
9endothelial tube morphogenesis (GO:0061154)4.44369341
10neutrophil activation involved in immune response (GO:0002283)4.38305283
11definitive hemopoiesis (GO:0060216)4.38082320
12negative regulation of cell killing (GO:0031342)4.30782493
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.30782493
14blood vessel maturation (GO:0001955)4.27229935
15viral transcription (GO:0019083)4.20650491
16angiogenesis involved in wound healing (GO:0060055)4.20428079
17endothelium development (GO:0003158)4.16899891
18platelet dense granule organization (GO:0060155)4.04598115
19translational termination (GO:0006415)3.99505922
20DNA deamination (GO:0045006)3.95581268
21negative thymic T cell selection (GO:0045060)3.94314185
22negative T cell selection (GO:0043383)3.93005274
23regulation of B cell receptor signaling pathway (GO:0050855)3.92978826
24lymph vessel development (GO:0001945)3.92447564
25positive regulation of B cell differentiation (GO:0045579)3.89743415
26negative regulation of phagocytosis (GO:0050765)3.84812130
27regulation of gamma-delta T cell differentiation (GO:0045586)3.80888705
28regulation of regulatory T cell differentiation (GO:0045589)3.71541756
29positive regulation of granulocyte differentiation (GO:0030854)3.62059688
30response to interferon-beta (GO:0035456)3.60746835
31SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.60199819
32positive regulation of T cell mediated cytotoxicity (GO:0001916)3.59600994
33antigen processing and presentation via MHC class Ib (GO:0002475)3.59471125
34megakaryocyte development (GO:0035855)3.56563172
35antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.55340664
36Arp2/3 complex-mediated actin nucleation (GO:0034314)3.54697480
37ribosomal small subunit biogenesis (GO:0042274)3.53665294
38cotranslational protein targeting to membrane (GO:0006613)3.50272935
39protein targeting to ER (GO:0045047)3.48385980
40negative regulation of nitric oxide biosynthetic process (GO:0045019)3.46692063
41regulation of vasculogenesis (GO:2001212)3.45688687
42translational elongation (GO:0006414)3.44752973
43regulation of gamma-delta T cell activation (GO:0046643)3.41363747
44telomere maintenance via semi-conservative replication (GO:0032201)3.33320522
45regulation of T cell mediated cytotoxicity (GO:0001914)3.30813557
46protein localization to endoplasmic reticulum (GO:0070972)3.30094801
47establishment of protein localization to endoplasmic reticulum (GO:0072599)3.29707206
48response to interleukin-15 (GO:0070672)3.21075523
49regulation of T cell tolerance induction (GO:0002664)3.21009291
50leukocyte aggregation (GO:0070486)3.20544020
51thrombin receptor signaling pathway (GO:0070493)3.18107680
52cellular response to interleukin-15 (GO:0071350)3.16797744
53cellular response to zinc ion (GO:0071294)3.16654162
54neutrophil activation (GO:0042119)3.16626403
55regulation of dendritic cell antigen processing and presentation (GO:0002604)3.14754819
56tolerance induction (GO:0002507)3.13885288
57DNA strand elongation involved in DNA replication (GO:0006271)3.12018571
58regulation of alpha-beta T cell proliferation (GO:0046640)3.10618524
59negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.09788136
60nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.09696904
61viral life cycle (GO:0019058)3.08351544
62secretory granule organization (GO:0033363)3.06890758
63maturation of SSU-rRNA (GO:0030490)3.06682236
64negative regulation of erythrocyte differentiation (GO:0045647)3.06123081
65regulation of B cell differentiation (GO:0045577)3.03413679
66positive regulation of interleukin-8 secretion (GO:2000484)3.03139284
67mast cell activation (GO:0045576)3.02291071
68positive regulation of tolerance induction (GO:0002645)3.02036647
69thymic T cell selection (GO:0045061)3.01724775
70B cell receptor signaling pathway (GO:0050853)3.01464470
71positive regulation of lamellipodium assembly (GO:0010592)3.01389110
72detection of bacterium (GO:0016045)3.00438238
73DNA strand elongation (GO:0022616)2.99127361
74T cell homeostasis (GO:0043029)2.98380876
75regulation of antigen processing and presentation (GO:0002577)2.98069325
76detection of other organism (GO:0098543)2.97676055
77positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.97489575
78positive regulation of alpha-beta T cell proliferation (GO:0046641)2.94875252
79T cell selection (GO:0045058)2.94529215
80regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.93713970
81regulation of natural killer cell mediated immunity (GO:0002715)2.93377534
82regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.93377534
83positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.93346389
84regulation of tolerance induction (GO:0002643)2.92240840
85autophagic vacuole fusion (GO:0000046)2.90232308
86negative regulation of nitric-oxide synthase activity (GO:0051001)2.89060648
87cellular protein complex disassembly (GO:0043624)2.88452364
88response to type I interferon (GO:0034340)2.86757122
89positive regulation of isotype switching (GO:0045830)2.86164122
90positive T cell selection (GO:0043368)2.84459905
91telomere maintenance via recombination (GO:0000722)2.84186821
92type I interferon signaling pathway (GO:0060337)2.82300976
93cellular response to type I interferon (GO:0071357)2.82300976
94cellular extravasation (GO:0045123)2.81436403
95regulation of mast cell degranulation (GO:0043304)2.80920076
96regulation of isotype switching to IgG isotypes (GO:0048302)2.80753543
97negative regulation of T-helper cell differentiation (GO:0045623)2.80563138
98negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.80563138
99lymph node development (GO:0048535)2.80181067
100translational initiation (GO:0006413)2.78770992
101regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.78471741
102regulation of leukocyte mediated cytotoxicity (GO:0001910)2.77876733
103response to protozoan (GO:0001562)2.76166698
104negative regulation of lymphocyte mediated immunity (GO:0002707)2.75803799
105regulation of mast cell activation (GO:0033003)2.75104554
106modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.74676845
107positive regulation by organism of defense response of other organism involved in symbiotic interact2.74676845
108modulation by symbiont of host immune response (GO:0052553)2.74676845
109positive regulation by symbiont of host defense response (GO:0052509)2.74676845
110modulation by symbiont of host defense response (GO:0052031)2.74676845
111modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.74676845
112positive regulation of antigen processing and presentation (GO:0002579)2.74409918
113positive regulation of DNA recombination (GO:0045911)2.73022935
114positive regulation of mast cell activation (GO:0033005)2.72971936
115granulocyte activation (GO:0036230)2.72669358
116regulation of endothelial cell differentiation (GO:0045601)2.72132792
117response to interferon-alpha (GO:0035455)2.71984105
118leukocyte degranulation (GO:0043299)2.71534174
119positive regulation of T cell mediated immunity (GO:0002711)2.70544483
120positive regulation of cell killing (GO:0031343)2.69865958
121cellular response to interferon-beta (GO:0035458)2.68965885
122positive regulation of natural killer cell mediated immunity (GO:0002717)2.68633531
123negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.67708207
124Peyers patch development (GO:0048541)2.67113689
125mucosal-associated lymphoid tissue development (GO:0048537)2.67113689
126myeloid dendritic cell activation (GO:0001773)2.66725662
127positive regulation of B cell mediated immunity (GO:0002714)2.65826233
128positive regulation of immunoglobulin mediated immune response (GO:0002891)2.65826233
129negative regulation of interleukin-12 production (GO:0032695)2.65757034
130positive regulation of endothelial cell differentiation (GO:0045603)2.65619250
131immunoglobulin mediated immune response (GO:0016064)2.65568295
132antigen receptor-mediated signaling pathway (GO:0050851)2.65135723
133negative regulation of T cell apoptotic process (GO:0070233)2.64894627
134regulation of mast cell activation involved in immune response (GO:0033006)2.64642039
135cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.64457950
136defense response to protozoan (GO:0042832)2.63100089
137vascular endothelial growth factor signaling pathway (GO:0038084)2.61864063
138interferon-gamma production (GO:0032609)2.61404882
139germinal center formation (GO:0002467)2.60825935
140positive regulation of lamellipodium organization (GO:1902745)2.60420566
141regulation of erythrocyte differentiation (GO:0045646)2.58282284
142embryonic hemopoiesis (GO:0035162)2.57844439
143regulation of necroptotic process (GO:0060544)2.56242422
144protein complex disassembly (GO:0043241)2.51980876
145mitotic recombination (GO:0006312)2.51649353
146positive regulation of DNA biosynthetic process (GO:2000573)2.50272939
147positive thymic T cell selection (GO:0045059)2.50250647
148regulation of T cell receptor signaling pathway (GO:0050856)2.48462998
149nuclear-transcribed mRNA catabolic process (GO:0000956)2.47334621
150necroptotic process (GO:0070266)2.46959547
151mast cell degranulation (GO:0043303)2.46843012
152mast cell activation involved in immune response (GO:0002279)2.46843012
153surfactant homeostasis (GO:0043129)2.45822629
154sprouting angiogenesis (GO:0002040)2.45264813
155positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.42993462
156regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.42692525
157B cell mediated immunity (GO:0019724)2.41930449
158lymphocyte homeostasis (GO:0002260)2.41424786
159actin nucleation (GO:0045010)2.38407858
160regulation of apoptotic cell clearance (GO:2000425)2.37963601
161mRNA catabolic process (GO:0006402)2.36325049
162telomere maintenance via telomere lengthening (GO:0010833)2.35812569
163T cell migration (GO:0072678)2.34222091
164negative regulation of stress fiber assembly (GO:0051497)2.34103607
165DNA replication initiation (GO:0006270)2.32592438

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.41821478
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.55124145
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.47835399
4SCL_19346495_ChIP-Seq_HPC-7_Human3.41954680
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.21988654
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.12566554
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.99221173
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.98836024
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.92588027
10* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.84274474
11* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.70594240
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.63439322
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.56520033
14* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.46058108
15* MYC_22102868_ChIP-Seq_BL_Human2.43223010
16GATA1_22025678_ChIP-Seq_K562_Human2.42690508
17IRF8_21731497_ChIP-ChIP_J774_Mouse2.40908957
18VDR_21846776_ChIP-Seq_THP-1_Human2.40122389
19FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.39387926
20* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.37858934
21SPI1_23547873_ChIP-Seq_NB4_Human2.19725695
22EGR1_19374776_ChIP-ChIP_THP-1_Human2.17577025
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.16516478
24STAT4_19710469_ChIP-ChIP_TH1__Mouse2.08453590
25MAF_26560356_Chip-Seq_TH1_Human2.05716455
26MYC_18555785_ChIP-Seq_MESCs_Mouse2.03145058
27MYB_26560356_Chip-Seq_TH2_Human2.00758621
28NOTCH1_21737748_ChIP-Seq_TLL_Human1.94107336
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.89547905
30E2F4_17652178_ChIP-ChIP_JURKAT_Human1.88459744
31VDR_24763502_ChIP-Seq_THP-1_Human1.84511947
32* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.83400705
33MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.82063152
34MYB_26560356_Chip-Seq_TH1_Human1.81026520
35FOXM1_23109430_ChIP-Seq_U2OS_Human1.80315807
36* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.80152151
37* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.79729536
38SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.78834875
39* GATA1_19941826_ChIP-Seq_K562_Human1.78080875
40* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.77744999
41RUNX1_22412390_ChIP-Seq_EML_Mouse1.77008416
42ERG_20887958_ChIP-Seq_HPC-7_Mouse1.75147162
43FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.74324752
44* UTX_26944678_Chip-Seq_JUKART_Human1.74035784
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.72011625
46NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.71400265
47* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.70587730
48GATA3_26560356_Chip-Seq_TH2_Human1.68528954
49IRF8_27001747_Chip-Seq_BMDM_Mouse1.65780269
50* RUNX_20019798_ChIP-Seq_JUKART_Human1.65057576
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.64597712
52BRD4_27068464_Chip-Seq_AML-cells_Mouse1.62094745
53* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.61885738
54GATA1_22383799_ChIP-Seq_G1ME_Mouse1.60693298
55EST1_17652178_ChIP-ChIP_JURKAT_Human1.57786789
56STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.57615466
57GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.56830410
58* ELK3_25401928_ChIP-Seq_HUVEC_Human1.55122970
59NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.54856728
60GABP_17652178_ChIP-ChIP_JURKAT_Human1.54304318
61MYC_18358816_ChIP-ChIP_MESCs_Mouse1.53381314
62* GATA2_21666600_ChIP-Seq_HMVEC_Human1.51185511
63BCL6_27268052_Chip-Seq_Bcells_Human1.51057280
64TCF7_22412390_ChIP-Seq_EML_Mouse1.50944686
65FOXP3_21729870_ChIP-Seq_TREG_Human1.47939343
66GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.47221359
67* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.46009073
68CIITA_25753668_ChIP-Seq_RAJI_Human1.43322854
69SPI1_23127762_ChIP-Seq_K562_Human1.41514019
70* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.39460849
71* VDR_23849224_ChIP-Seq_CD4+_Human1.38041871
72PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.35704247
73KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.33958419
74JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.32750785
75* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.32419596
76MAF_26560356_Chip-Seq_TH2_Human1.31305417
77RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.29049429
78ELF1_20517297_ChIP-Seq_JURKAT_Human1.28050209
79XRN2_22483619_ChIP-Seq_HELA_Human1.27487683
80CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.26868933
81HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.24452070
82ETS1_20019798_ChIP-Seq_JURKAT_Human1.24096545
83MYC_19030024_ChIP-ChIP_MESCs_Mouse1.23151278
84SPI1_20517297_ChIP-Seq_HL60_Human1.22475009
85* GATA2_19941826_ChIP-Seq_K562_Human1.20998360
86* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.20875710
87* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20025499
88IKZF1_21737484_ChIP-ChIP_HCT116_Human1.19778065
89P300_27268052_Chip-Seq_Bcells_Human1.15934991
90MYC_19079543_ChIP-ChIP_MESCs_Mouse1.15489478
91FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.14052690
92NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.13956132
93* GATA1_19941827_ChIP-Seq_MEL_Mouse1.13255892
94BCOR_27268052_Chip-Seq_Bcells_Human1.12441687
95KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12396151
96STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.11714861
97SMAD_19615063_ChIP-ChIP_OVARY_Human1.09470456
98SRF_21415370_ChIP-Seq_HL-1_Mouse1.09149485
99VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.08707758
100CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.08103014
101* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07343748
102VDR_24787735_ChIP-Seq_THP-1_Human1.07104398
103Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.06072153
104GATA3_27048872_Chip-Seq_THYMUS_Human1.05042153
105* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04628096
106NELFA_20434984_ChIP-Seq_ESCs_Mouse1.04609464
107EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.04194168
108SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01811181
109PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01734651
110* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01325150
111ELK1_19687146_ChIP-ChIP_HELA_Human1.00907202
112E2F1_21310950_ChIP-Seq_MCF-7_Human1.00761583
113VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.00175724
114* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.99210251
115GABP_19822575_ChIP-Seq_HepG2_Human0.98478564
116TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97620918
117E2F1_18555785_ChIP-Seq_MESCs_Mouse0.97358161
118RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.96718594
119HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.94873897
120STAT6_21828071_ChIP-Seq_BEAS2B_Human0.94183616
121DCP1A_22483619_ChIP-Seq_HELA_Human0.93975292
122PU_27001747_Chip-Seq_BMDM_Mouse0.93433691
123CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92686490
124NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.91427127
125* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91170272
126TTF2_22483619_ChIP-Seq_HELA_Human0.90771641
127* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.90485830
128RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.90433455
129* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90383668
130CREB1_15753290_ChIP-ChIP_HEK293T_Human0.89752172
131* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89746362
132* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89007666
133STAT1_20625510_ChIP-Seq_HELA_Human0.88678012
134EGR1_23403033_ChIP-Seq_LIVER_Mouse0.85627071
135NCOR1_26117541_ChIP-Seq_K562_Human0.80887890

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system3.87969425
2MP0003724_increased_susceptibility_to3.86234291
3MP0001879_abnormal_lymphatic_vessel3.64719887
4MP0002396_abnormal_hematopoietic_system3.19342929
5MP0001835_abnormal_antigen_presentation2.86480130
6MP0006054_spinal_hemorrhage2.77997547
7MP0005671_abnormal_response_to2.54978280
8MP0009785_altered_susceptibility_to2.52816104
9MP0003763_abnormal_thymus_physiology2.50860736
10MP0000465_gastrointestinal_hemorrhage2.43604335
11MP0005167_abnormal_blood-brain_barrier2.41419776
12MP0000685_abnormal_immune_system2.38187931
13MP0002166_altered_tumor_susceptibility2.31058435
14MP0004808_abnormal_hematopoietic_stem2.24320826
15MP0001800_abnormal_humoral_immune2.16778469
16MP0001545_abnormal_hematopoietic_system2.15441981
17MP0005397_hematopoietic_system_phenotyp2.15441981
18MP0005025_abnormal_response_to2.12492552
19MP0005464_abnormal_platelet_physiology2.07168375
20* MP0002420_abnormal_adaptive_immunity2.03471149
21* MP0002398_abnormal_bone_marrow2.01955529
22MP0009333_abnormal_splenocyte_physiolog2.01716840
23* MP0001819_abnormal_immune_cell1.99650678
24MP0002452_abnormal_antigen_presenting1.98448883
25MP0005387_immune_system_phenotype1.98223283
26MP0001790_abnormal_immune_system1.98223283
27MP0003828_pulmonary_edema1.93926745
28MP0005000_abnormal_immune_tolerance1.93720077
29MP0002723_abnormal_immune_serum1.89372444
30MP0006082_CNS_inflammation1.87475641
31MP0002419_abnormal_innate_immunity1.86807008
32MP0003436_decreased_susceptibility_to1.84175433
33MP0002148_abnormal_hypersensitivity_rea1.83536525
34MP0000716_abnormal_immune_system1.77803795
35MP0001853_heart_inflammation1.76279606
36MP0004147_increased_porphyrin_level1.75250203
37MP0000689_abnormal_spleen_morphology1.73774876
38MP0003191_abnormal_cellular_cholesterol1.69846564
39MP0002722_abnormal_immune_system1.68671820
40MP0010155_abnormal_intestine_physiology1.67444552
41MP0002429_abnormal_blood_cell1.67008314
42MP0002405_respiratory_system_inflammati1.64520929
43MP0001873_stomach_inflammation1.60409147
44MP0005084_abnormal_gallbladder_morpholo1.56669785
45MP0009379_abnormal_foot_pigmentation1.54413795
46MP0002006_tumorigenesis1.53525324
47MP0003303_peritoneal_inflammation1.49514176
48MP0002138_abnormal_hepatobiliary_system1.44952825
49MP0000343_altered_response_to1.43572027
50MP0000490_abnormal_crypts_of1.43528538
51MP0002132_abnormal_respiratory_system1.42459567
52MP0005174_abnormal_tail_pigmentation1.40881485
53MP0009278_abnormal_bone_marrow1.40084738
54MP0000249_abnormal_blood_vessel1.37407996
55MP0000703_abnormal_thymus_morphology1.36962527
56MP0000767_abnormal_smooth_muscle1.36071508
57MP0003693_abnormal_embryo_hatching1.32811105
58MP0001845_abnormal_inflammatory_respons1.27035242
59MP0005075_abnormal_melanosome_morpholog1.20442696
60MP0008004_abnormal_stomach_pH1.20143656
61MP0001533_abnormal_skeleton_physiology1.19102959
62MP0003866_abnormal_defecation1.14694938
63MP0003806_abnormal_nucleotide_metabolis1.12701247
64MP0003943_abnormal_hepatobiliary_system1.11362386
65MP0004782_abnormal_surfactant_physiolog1.10145478
66MP0003077_abnormal_cell_cycle1.08032126
67MP0004272_abnormal_basement_membrane1.07903533
68MP0010094_abnormal_chromosome_stability1.06288265
69MP0008007_abnormal_cellular_replicative1.06155567
70MP0008469_abnormal_protein_level1.05485643
71MP0003279_aneurysm1.05238450
72MP0005409_darkened_coat_color1.03452110
73MP0003300_gastrointestinal_ulcer1.00606580
74MP0002019_abnormal_tumor_incidence0.99819602
75MP0005310_abnormal_salivary_gland0.99249785
76MP0004947_skin_inflammation0.98800852
77MP0004084_abnormal_cardiac_muscle0.97874403
78MP0002095_abnormal_skin_pigmentation0.95395684
79MP0008057_abnormal_DNA_replication0.94168402
80MP0001851_eye_inflammation0.93692154
81MP0003567_abnormal_fetal_cardiomyocyte0.91263433
82MP0001915_intracranial_hemorrhage0.89866658
83MP0000858_altered_metastatic_potential0.88741223
84MP0005165_increased_susceptibility_to0.88615490
85MP0005166_decreased_susceptibility_to0.87853145
86MP0009697_abnormal_copulation0.86219850
87MP0000015_abnormal_ear_pigmentation0.85992487
88MP0002933_joint_inflammation0.83794515
89MP0003638_abnormal_response/metabolism_0.81611392
90MP0004484_altered_response_of0.80061437
91MP0002128_abnormal_blood_circulation0.79418346
92MP0005023_abnormal_wound_healing0.78947124
93MP0003045_fibrosis0.78664750
94MP0004957_abnormal_blastocyst_morpholog0.77740522
95MP0003111_abnormal_nucleus_morphology0.76719342
96MP0003566_abnormal_cell_adhesion0.75262466
97MP0005058_abnormal_lysosome_morphology0.74703021
98MP0009764_decreased_sensitivity_to0.74582668
99MP0004510_myositis0.73881292
100MP0006036_abnormal_mitochondrial_physio0.73237647
101MP0003448_altered_tumor_morphology0.72333059
102MP0003075_altered_response_to0.72321963
103MP0004883_abnormal_blood_vessel0.72154348
104MP0009765_abnormal_xenobiotic_induced0.72042871
105MP0005385_cardiovascular_system_phenoty0.71847600
106MP0001544_abnormal_cardiovascular_syste0.71847600
107MP0001614_abnormal_blood_vessel0.71584644
108MP0002332_abnormal_exercise_endurance0.70501998
109MP0000230_abnormal_systemic_arterial0.69471081
110MP0001663_abnormal_digestive_system0.68549820
111MP0003186_abnormal_redox_activity0.68114833
112MP0005410_abnormal_fertilization0.67870936
113MP0005164_abnormal_response_to0.67862387
114MP0002998_abnormal_bone_remodeling0.67759254
115MP0009763_increased_sensitivity_to0.66972940
116MP0006138_congestive_heart_failure0.66086315
117MP0005390_skeleton_phenotype0.64904125
118MP0002925_abnormal_cardiovascular_devel0.64645538
119MP0008872_abnormal_physiological_respon0.62056270
120MP0002127_abnormal_cardiovascular_syste0.61967451
121MP0005595_abnormal_vascular_smooth0.58378406
122MP0008874_decreased_physiological_sensi0.56996513
123MP0008775_abnormal_heart_ventricle0.56808857
124MP0005535_abnormal_body_temperature0.56279585
125MP0005381_digestive/alimentary_phenotyp0.56047480
126MP0002277_abnormal_respiratory_mucosa0.55241581
127MP0005645_abnormal_hypothalamus_physiol0.53032660
128MP0002693_abnormal_pancreas_physiology0.52626423
129MP0008873_increased_physiological_sensi0.51935251

Predicted human phenotypes

RankGene SetZ-score
1Spontaneous hematomas (HP:0007420)5.14661802
2Abnormality of the nasal mucosa (HP:0000433)5.04023397
3Stomatitis (HP:0010280)4.53604675
4Elevated erythrocyte sedimentation rate (HP:0003565)4.53559878
5Thrombocytosis (HP:0001894)4.37810386
6IgM deficiency (HP:0002850)4.13594527
7Chronic otitis media (HP:0000389)3.89565931
8Prolonged bleeding time (HP:0003010)3.89106289
9Abnormal number of erythroid precursors (HP:0012131)3.87694933
10Petechiae (HP:0000967)3.86136023
11Abnormality of cells of the erythroid lineage (HP:0012130)3.81573605
12Reticulocytopenia (HP:0001896)3.75598705
13Recurrent bronchitis (HP:0002837)3.66001683
14Hematochezia (HP:0002573)3.65999873
15Menorrhagia (HP:0000132)3.62668124
16Polycythemia (HP:0001901)3.56732575
17Increased IgM level (HP:0003496)3.54472551
18Autoimmune hemolytic anemia (HP:0001890)3.49140424
19Recurrent abscess formation (HP:0002722)3.48688345
20Myositis (HP:0100614)3.43528390
21Aplastic anemia (HP:0001915)3.40082695
22Retrobulbar optic neuritis (HP:0100654)3.33185428
23Optic neuritis (HP:0100653)3.33185428
24Encephalitis (HP:0002383)3.29488348
25Nasal polyposis (HP:0100582)3.27350452
26Epistaxis (HP:0000421)3.27196064
27Recurrent viral infections (HP:0004429)3.15321295
28Microcytic anemia (HP:0001935)3.14778403
29Eczematoid dermatitis (HP:0000976)3.12608045
30Reduced antithrombin III activity (HP:0001976)3.05022471
31Abnormal delayed hypersensitivity skin test (HP:0002963)3.03822066
32Recurrent fungal infections (HP:0002841)2.92878011
33Abnormality of T cell physiology (HP:0011840)2.91961011
34Cellulitis (HP:0100658)2.91740168
35Nonimmune hydrops fetalis (HP:0001790)2.89000023
36Panhypogammaglobulinemia (HP:0003139)2.86735915
37Gingival bleeding (HP:0000225)2.86362017
38Abnormality of T cells (HP:0002843)2.86282705
39Agammaglobulinemia (HP:0004432)2.85713307
40Increased mean platelet volume (HP:0011877)2.80873100
41Gastrointestinal inflammation (HP:0004386)2.75089414
42Meningitis (HP:0001287)2.70898999
43Inflammation of the large intestine (HP:0002037)2.69902008
44IgG deficiency (HP:0004315)2.67702818
45Recurrent bacterial skin infections (HP:0005406)2.66522607
46Abnormal platelet function (HP:0011869)2.63488890
47Impaired platelet aggregation (HP:0003540)2.63488890
48T lymphocytopenia (HP:0005403)2.61843092
49Abnormality of T cell number (HP:0011839)2.61124637
50Interstitial pulmonary disease (HP:0006530)2.60730384
51Pustule (HP:0200039)2.59901411
52Hypertensive crisis (HP:0100735)2.55768391
53Colitis (HP:0002583)2.51705123
54B lymphocytopenia (HP:0010976)2.51682992
55Abnormality of B cell number (HP:0010975)2.51682992
56Type I transferrin isoform profile (HP:0003642)2.51519490
57Increased IgE level (HP:0003212)2.43526091
58Reduced subcutaneous adipose tissue (HP:0003758)2.41995147
59Hemoptysis (HP:0002105)2.41485649
60Lymphopenia (HP:0001888)2.40767224
6111 pairs of ribs (HP:0000878)2.40680237
62Keratoconjunctivitis (HP:0001096)2.40603001
63Hyperlipoproteinemia (HP:0010980)2.39429627
64Abnormality of cells of the lymphoid lineage (HP:0012140)2.38354182
65Hypergammaglobulinemia (HP:0010702)2.36145546
66Arterial thrombosis (HP:0004420)2.34919053
67Keratoconjunctivitis sicca (HP:0001097)2.34815999
68Recurrent cutaneous fungal infections (HP:0011370)2.32741848
69Chronic mucocutaneous candidiasis (HP:0002728)2.32741848
70Leukocytosis (HP:0001974)2.31867589
71Gastrointestinal infarctions (HP:0005244)2.31636099
72Conjunctival telangiectasia (HP:0000524)2.26483950
73Pallor (HP:0000980)2.26325750
74Recurrent skin infections (HP:0001581)2.26302867
75Cerebral hemorrhage (HP:0001342)2.24786986
76Hepatosplenomegaly (HP:0001433)2.23020907
77Episodic fever (HP:0001954)2.20666691
78Pulmonary embolism (HP:0002204)2.20152835
79Severe combined immunodeficiency (HP:0004430)2.20010321
80Abnormality of iron homeostasis (HP:0011031)2.19533690
81Joint swelling (HP:0001386)2.19491621
82Purpura (HP:0000979)2.19291976
83Urticaria (HP:0001025)2.18712721
84Thyroiditis (HP:0100646)2.18580509
85Vasculitis (HP:0002633)2.17771500
86Chest pain (HP:0100749)2.17639318
87Bronchitis (HP:0012387)2.17091413
88Systemic lupus erythematosus (HP:0002725)2.16385749
89Abnormality of the vasculature of the conjunctiva (HP:0008054)2.15413769
90Orchitis (HP:0100796)2.14585251
91Autoimmune thrombocytopenia (HP:0001973)2.14454497
92Gastrointestinal stroma tumor (HP:0100723)2.14236261
93Mucosal telangiectasiae (HP:0100579)2.13585534
94Granulocytopenia (HP:0001913)2.13466189
95Mediastinal lymphadenopathy (HP:0100721)2.13337684
96Vertigo (HP:0002321)2.13319786
97Abnormality of the pleura (HP:0002103)2.11995216
98Abnormality of transition element cation homeostasis (HP:0011030)2.09616099
99Abnormality of the prostate (HP:0008775)2.09157279
100Abnormality of eosinophils (HP:0001879)2.09054175
101Anorexia (HP:0002039)2.08726313
1023-Methylglutaconic aciduria (HP:0003535)2.08678421
103Lymphoma (HP:0002665)2.07590888
104Obstructive lung disease (HP:0006536)2.06424231
105Chronic obstructive pulmonary disease (HP:0006510)2.06424231
106Eosinophilia (HP:0001880)2.05384667
107Recurrent gram-negative bacterial infections (HP:0005420)2.05030210
108Chronic sinusitis (HP:0011109)2.04785380
109Abnormality of macrophages (HP:0004311)2.03846338
110Skin rash (HP:0000988)2.02744675
111Increased serum ferritin (HP:0003281)2.01089964
112Abnormal protein glycosylation (HP:0012346)2.00535684
113Abnormal glycosylation (HP:0012345)2.00535684
114Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.00535684
115Abnormal protein N-linked glycosylation (HP:0012347)2.00535684
116Abnormal platelet volume (HP:0011876)2.00365377
117Pulmonary infiltrates (HP:0002113)2.00022154
118Esophageal varix (HP:0002040)1.99362179
119Hypochromic anemia (HP:0001931)1.98032112
120Hypoplasia of the thymus (HP:0000778)1.97132709
121Verrucae (HP:0200043)1.92873407
122Papilloma (HP:0012740)1.92873407
123Combined immunodeficiency (HP:0005387)1.92418462
124Albinism (HP:0001022)1.92389936
125IgA deficiency (HP:0002720)1.91354287
126Abnormality of the heme biosynthetic pathway (HP:0010472)1.91060510
127Pancytopenia (HP:0001876)1.90119122
128Papilledema (HP:0001085)1.87964590
129Thrombophlebitis (HP:0004418)1.87536360
130Fatigue (HP:0012378)1.87436887
131Macrocytic anemia (HP:0001972)1.86476479

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE16.25272639
2KDR4.82293854
3MAP4K13.82314898
4TGFBR23.12670734
5TGFBR12.92868117
6RIPK42.62267813
7TEC2.46214917
8KIT2.24522148
9BTK2.02571128
10ERN11.97900325
11ZAP701.94664560
12TXK1.89735956
13NME21.79440825
14MAP2K31.73913556
15BLK1.68325623
16VRK21.60345841
17TBK11.59253071
18JAK31.52541114
19TNK21.51514793
20PIM21.48109750
21IRAK41.47435748
22STK101.46979592
23IKBKE1.41450022
24TYK21.37462687
25NUAK11.34553515
26LRRK21.33672918
27MYLK1.32942804
28BUB11.32090614
29FLT31.31228603
30WEE11.29523470
31FES1.26323880
32PKN21.24895383
33SYK1.19355321
34MAP3K121.19246852
35STK161.13427171
36CLK11.12277489
37ITK1.11438649
38INSRR1.09963389
39VRK11.06860053
40CDK81.05989269
41GRK11.05828655
42CSF1R1.03167169
43GRK51.02962004
44RIPK11.01525891
45MAP3K141.01137267
46ACVR1B1.00068087
47NLK0.99846160
48GRK60.96661585
49TAOK30.95308641
50LCK0.94950600
51PAK40.93265867
52CSK0.93065945
53FER0.92895040
54BRSK20.90606183
55EIF2AK30.89694459
56PRKCQ0.88815711
57RPS6KA40.88337373
58EEF2K0.86536169
59MAP3K110.86064763
60PIM10.85020919
61LYN0.84869717
62MAP3K130.84609490
63MATK0.82225787
64HCK0.77198369
65TLK10.76790573
66NEK20.76775847
67CDC70.75364996
68FGR0.75301099
69PIK3CG0.73081630
70RPS6KB20.72624758
71BMPR20.71176090
72IKBKB0.70841671
73PRKG20.70356913
74MAP4K20.67604046
75TNIK0.66457926
76CDK70.66174297
77ADRBK20.65286959
78BMX0.65194060
79SIK30.62849782
80MAP3K10.61988018
81TSSK60.61674687
82RPS6KA60.58776848
83BMPR1B0.58769412
84ILK0.58652155
85DYRK30.58257834
86MAPK40.57750581
87CDK40.57554481
88CAMKK20.56905861
89STK40.56154885
90FGFR40.55026098
91MAPK120.54959619
92CCNB10.54362590
93JAK10.54134853
94MAP3K100.53406610
95EIF2AK10.52959689
96EPHA30.52927245
97SCYL20.51204941
98DAPK10.50953815
99PTK60.50560722
100IRAK10.49146502
101TESK20.49109256
102RPS6KL10.47085493
103RPS6KC10.47085493
104MST40.46839970
105EPHB10.45790991
106SRPK10.44288326
107MAPKAPK30.43092125
108MAP2K20.43065767
109TRPM70.41798587
110EIF2AK20.40498150
111PDK10.40276321
112ADRBK10.39804000
113ATR0.38780802
114PASK0.38122985
115CAMK10.37991925
116TESK10.37517662
117FYN0.37460882
118MARK30.37135279
119MAP3K30.37131617
120MKNK10.36038370
121PTK2B0.35715512
122BCKDK0.35549392
123ZAK0.35466245
124MAP3K60.34576426
125JAK20.34547405
126MAP2K60.34246237
127MAP3K70.34103991
128MAPK110.33837228
129MAPK70.32661879
130PRKCD0.32543268
131MAP3K80.32332482
132HIPK20.31176020
133IGF1R0.30541081
134AURKB0.30126865
135DAPK20.29521982
136FRK0.29150642
137DAPK30.29000516
138PRKD10.28254935
139GRK70.27392945
140INSR0.25946344

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.86122695
2Ribosome_Homo sapiens_hsa030103.59720590
3Autoimmune thyroid disease_Homo sapiens_hsa053203.42189703
4Primary immunodeficiency_Homo sapiens_hsa053403.30911156
5Type I diabetes mellitus_Homo sapiens_hsa049402.67619354
6Mismatch repair_Homo sapiens_hsa034302.57840582
7Base excision repair_Homo sapiens_hsa034102.50870547
8Hematopoietic cell lineage_Homo sapiens_hsa046402.24871922
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.07819982
10Leishmaniasis_Homo sapiens_hsa051402.03432723
11Antigen processing and presentation_Homo sapiens_hsa046121.92255874
12Intestinal immune network for IgA production_Homo sapiens_hsa046721.82291899
13Measles_Homo sapiens_hsa051621.81037339
14Homologous recombination_Homo sapiens_hsa034401.80912178
15B cell receptor signaling pathway_Homo sapiens_hsa046621.72410583
16Other glycan degradation_Homo sapiens_hsa005111.70148955
17Rheumatoid arthritis_Homo sapiens_hsa053231.69992343
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.65926492
19Leukocyte transendothelial migration_Homo sapiens_hsa046701.64707861
20Spliceosome_Homo sapiens_hsa030401.64463455
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.59890363
22Staphylococcus aureus infection_Homo sapiens_hsa051501.57058073
23Herpes simplex infection_Homo sapiens_hsa051681.56696582
24Proteasome_Homo sapiens_hsa030501.50818823
25Caffeine metabolism_Homo sapiens_hsa002321.50419559
26* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.48119417
27Pyrimidine metabolism_Homo sapiens_hsa002401.47266886
28Platelet activation_Homo sapiens_hsa046111.47051029
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.44062909
30Malaria_Homo sapiens_hsa051441.43313115
31Nucleotide excision repair_Homo sapiens_hsa034201.43050911
32Pertussis_Homo sapiens_hsa051331.41681908
33Viral myocarditis_Homo sapiens_hsa054161.32677799
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.30835587
35RNA polymerase_Homo sapiens_hsa030201.26991332
36Non-homologous end-joining_Homo sapiens_hsa034501.25246922
37Shigellosis_Homo sapiens_hsa051311.24690173
38Osteoclast differentiation_Homo sapiens_hsa043801.24177214
39Legionellosis_Homo sapiens_hsa051341.23724099
40Jak-STAT signaling pathway_Homo sapiens_hsa046301.14153402
41Cell cycle_Homo sapiens_hsa041101.11523904
42Toxoplasmosis_Homo sapiens_hsa051451.08806566
43Protein export_Homo sapiens_hsa030601.08294521
44Arachidonic acid metabolism_Homo sapiens_hsa005901.08180875
45N-Glycan biosynthesis_Homo sapiens_hsa005101.05743790
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.02798121
47RNA degradation_Homo sapiens_hsa030181.01059896
48Glycosaminoglycan degradation_Homo sapiens_hsa005311.00202308
49Transcriptional misregulation in cancer_Homo sapiens_hsa052020.99888148
50Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.95749905
51Influenza A_Homo sapiens_hsa051640.95000676
52T cell receptor signaling pathway_Homo sapiens_hsa046600.94555073
53Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.94497179
54Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.94012768
55Small cell lung cancer_Homo sapiens_hsa052220.93652989
56Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.93323532
57Pentose phosphate pathway_Homo sapiens_hsa000300.89696550
58Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.88704241
59Purine metabolism_Homo sapiens_hsa002300.88690699
60Hepatitis B_Homo sapiens_hsa051610.87589103
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87148077
62Acute myeloid leukemia_Homo sapiens_hsa052210.87037390
63Toll-like receptor signaling pathway_Homo sapiens_hsa046200.86519540
64Apoptosis_Homo sapiens_hsa042100.85015548
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83853057
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.83513247
67HTLV-I infection_Homo sapiens_hsa051660.82994713
68Sulfur relay system_Homo sapiens_hsa041220.82144469
69Allograft rejection_Homo sapiens_hsa053300.82029535
70Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.81876690
71Fanconi anemia pathway_Homo sapiens_hsa034600.81438260
72Salmonella infection_Homo sapiens_hsa051320.81190206
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79587813
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.79274827
75Phagosome_Homo sapiens_hsa041450.79181375
76Epstein-Barr virus infection_Homo sapiens_hsa051690.77300891
77Thyroid cancer_Homo sapiens_hsa052160.76726221
78p53 signaling pathway_Homo sapiens_hsa041150.75570382
79Complement and coagulation cascades_Homo sapiens_hsa046100.74547480
80Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73432631
81Linoleic acid metabolism_Homo sapiens_hsa005910.72102699
82RNA transport_Homo sapiens_hsa030130.71902825
83TNF signaling pathway_Homo sapiens_hsa046680.67141789
84NOD-like receptor signaling pathway_Homo sapiens_hsa046210.66683277
85Chemokine signaling pathway_Homo sapiens_hsa040620.66635400
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66106744
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61549429
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61447947
89Viral carcinogenesis_Homo sapiens_hsa052030.61410851
90Systemic lupus erythematosus_Homo sapiens_hsa053220.56734998
91Chronic myeloid leukemia_Homo sapiens_hsa052200.56670914
92Notch signaling pathway_Homo sapiens_hsa043300.56191474
93Sulfur metabolism_Homo sapiens_hsa009200.55097201
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53233870
95Endocytosis_Homo sapiens_hsa041440.53000563
96Graft-versus-host disease_Homo sapiens_hsa053320.52570718
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.51639224
98Tuberculosis_Homo sapiens_hsa051520.51019865
99African trypanosomiasis_Homo sapiens_hsa051430.50616820
100Focal adhesion_Homo sapiens_hsa045100.50418051
101HIF-1 signaling pathway_Homo sapiens_hsa040660.48917101
102Hepatitis C_Homo sapiens_hsa051600.48173688
103Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45753887
104Regulation of autophagy_Homo sapiens_hsa041400.45579773
105Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45059150
106Asthma_Homo sapiens_hsa053100.44548009
107Galactose metabolism_Homo sapiens_hsa000520.44400153
108Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43546739
109Rap1 signaling pathway_Homo sapiens_hsa040150.43093268
110Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42459575
111* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41181552
112Pancreatic cancer_Homo sapiens_hsa052120.41140013
113PI3K-Akt signaling pathway_Homo sapiens_hsa041510.39816618
114Drug metabolism - other enzymes_Homo sapiens_hsa009830.39225017
115Phototransduction_Homo sapiens_hsa047440.38342137
116Parkinsons disease_Homo sapiens_hsa050120.36789704
117Pathways in cancer_Homo sapiens_hsa052000.36304112
118VEGF signaling pathway_Homo sapiens_hsa043700.34369988
119Vascular smooth muscle contraction_Homo sapiens_hsa042700.33876750
120Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.33386620
121Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33173382
122Glycerolipid metabolism_Homo sapiens_hsa005610.33043474
123Olfactory transduction_Homo sapiens_hsa047400.30232474
124Oxidative phosphorylation_Homo sapiens_hsa001900.28294489
125Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.28251795
126Lysosome_Homo sapiens_hsa041420.28001111
127Ras signaling pathway_Homo sapiens_hsa040140.25006152
128Sphingolipid signaling pathway_Homo sapiens_hsa040710.23210596
129Ether lipid metabolism_Homo sapiens_hsa005650.23089273
130Peroxisome_Homo sapiens_hsa041460.22547511
131Nitrogen metabolism_Homo sapiens_hsa009100.22241240
132Renin-angiotensin system_Homo sapiens_hsa046140.22031414
133Adipocytokine signaling pathway_Homo sapiens_hsa049200.20133823

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