ICAM3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)6.74424064
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.74424064
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.72415644
4positive regulation of gamma-delta T cell activation (GO:0046645)6.25768812
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.20661835
6antigen processing and presentation of endogenous antigen (GO:0019883)6.14514237
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.59305679
8regulation of B cell receptor signaling pathway (GO:0050855)5.34080754
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.28933749
10positive regulation by organism of defense response of other organism involved in symbiotic interact5.28933749
11modulation by symbiont of host immune response (GO:0052553)5.28933749
12positive regulation by symbiont of host defense response (GO:0052509)5.28933749
13modulation by symbiont of host defense response (GO:0052031)5.28933749
14modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.28933749
15positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.04344455
16detection of other organism (GO:0098543)4.99657119
17neutrophil activation involved in immune response (GO:0002283)4.98303889
18detection of bacterium (GO:0016045)4.95486094
19leukocyte aggregation (GO:0070486)4.92218979
20response to interleukin-15 (GO:0070672)4.59319784
21regulation of gamma-delta T cell activation (GO:0046643)4.55961752
22negative regulation of lymphocyte mediated immunity (GO:0002707)4.41485815
23regulation of gamma-delta T cell differentiation (GO:0045586)4.32816053
24cellular response to interleukin-15 (GO:0071350)4.32114569
25response to peptidoglycan (GO:0032494)4.23503398
26macrophage activation involved in immune response (GO:0002281)4.21875033
27immunoglobulin mediated immune response (GO:0016064)4.21309500
28cellular extravasation (GO:0045123)4.08227129
29neutrophil activation (GO:0042119)4.08003774
30detection of external biotic stimulus (GO:0098581)4.05069024
31respiratory burst (GO:0045730)4.03087037
32negative thymic T cell selection (GO:0045060)4.02954014
33negative T cell selection (GO:0043383)4.01833462
34negative regulation of leukocyte mediated immunity (GO:0002704)3.96489206
35B cell receptor signaling pathway (GO:0050853)3.91053754
36regulation of B cell differentiation (GO:0045577)3.87692984
37positive thymic T cell selection (GO:0045059)3.87618826
38positive regulation of B cell differentiation (GO:0045579)3.85895895
39negative regulation of interleukin-12 production (GO:0032695)3.84509167
40response to host immune response (GO:0052572)3.78008021
41response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.78008021
42negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.76809615
43negative regulation of T cell mediated immunity (GO:0002710)3.73207068
44leukocyte migration involved in inflammatory response (GO:0002523)3.72991681
45regulation of interferon-beta biosynthetic process (GO:0045357)3.71596822
46granulocyte activation (GO:0036230)3.65115780
47negative regulation of phagocytosis (GO:0050765)3.60019289
48myeloid cell activation involved in immune response (GO:0002275)3.55318956
49regulation of mast cell degranulation (GO:0043304)3.54508049
50detection of biotic stimulus (GO:0009595)3.54145550
51cellular response to type I interferon (GO:0071357)3.46725760
52type I interferon signaling pathway (GO:0060337)3.46725760
53response to host (GO:0075136)3.46475277
54response to host defenses (GO:0052200)3.46475277
55response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.46475277
56tolerance induction (GO:0002507)3.45384297
57antigen processing and presentation via MHC class Ib (GO:0002475)3.44475528
58response to type I interferon (GO:0034340)3.44377417
59regulation of T cell tolerance induction (GO:0002664)3.43299014
60T cell migration (GO:0072678)3.42818009
61B cell mediated immunity (GO:0019724)3.42572420
62detection of molecule of bacterial origin (GO:0032490)3.41838352
63regulation of alpha-beta T cell proliferation (GO:0046640)3.41702024
64leukocyte degranulation (GO:0043299)3.38661559
65positive T cell selection (GO:0043368)3.38256537
66regulation of T cell mediated cytotoxicity (GO:0001914)3.37979032
67positive regulation of T cell mediated cytotoxicity (GO:0001916)3.37899294
68microglial cell activation (GO:0001774)3.35249935
69neutrophil mediated immunity (GO:0002446)3.34382082
70positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.34200340
71regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.33453685
72regulation of natural killer cell mediated immunity (GO:0002715)3.33453685
73T cell selection (GO:0045058)3.29336949
74regulation of tolerance induction (GO:0002643)3.28776292
75negative regulation of erythrocyte differentiation (GO:0045647)3.27636702
76response to muramyl dipeptide (GO:0032495)3.26282340
77regulation of myeloid leukocyte mediated immunity (GO:0002886)3.24745215
78regulation of mast cell activation involved in immune response (GO:0033006)3.24462630
79thymic T cell selection (GO:0045061)3.23971753
80positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.18968958
81defense response to protozoan (GO:0042832)3.18402603
82interferon-gamma-mediated signaling pathway (GO:0060333)3.14728962
83negative regulation of innate immune response (GO:0045824)3.13862151
84production of molecular mediator involved in inflammatory response (GO:0002532)3.11965671
85regulation of regulatory T cell differentiation (GO:0045589)3.10996108
86positive regulation of mast cell activation (GO:0033005)3.10213040
87negative regulation of T-helper cell differentiation (GO:0045623)3.10203514
88negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.10203514
89regulation of leukocyte degranulation (GO:0043300)3.09964597
90regulation of mast cell activation (GO:0033003)3.08519275
91regulation of dendritic cell antigen processing and presentation (GO:0002604)3.07215433
92regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.07004496
93macrophage activation (GO:0042116)3.06907723
94germinal center formation (GO:0002467)3.03469769
95positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.01999469
96activated T cell proliferation (GO:0050798)2.97646983
97regulation of antigen processing and presentation (GO:0002577)2.96991943
98negative regulation of interleukin-6 production (GO:0032715)2.94396366
99antigen receptor-mediated signaling pathway (GO:0050851)2.94305032
100negative regulation of alpha-beta T cell activation (GO:0046636)2.91347825

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.60757676
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.67410698
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.01282784
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.75755007
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.67264521
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.43183644
7VDR_21846776_ChIP-Seq_THP-1_Human3.02601991
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.95692755
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.91192425
10RUNX_20019798_ChIP-Seq_JUKART_Human2.85367890
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.84318852
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.83318453
13* SPI1_23547873_ChIP-Seq_NB4_Human2.78656802
14RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.76386975
15MYB_26560356_Chip-Seq_TH2_Human2.68800866
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.67052804
17MYC_22102868_ChIP-Seq_BL_Human2.66913185
18VDR_24763502_ChIP-Seq_THP-1_Human2.66092004
19MAF_26560356_Chip-Seq_TH1_Human2.66054240
20UTX_26944678_Chip-Seq_JUKART_Human2.50922499
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.45499271
22SCL_19346495_ChIP-Seq_HPC-7_Human2.45266368
23E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.42072454
24MYB_21317192_ChIP-Seq_ERMYB_Mouse2.39383376
25SPI1_23127762_ChIP-Seq_K562_Human2.36283218
26STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.35210930
27STAT4_19710469_ChIP-ChIP_TH1__Mouse2.34107641
28RUNX1_22412390_ChIP-Seq_EML_Mouse2.31477976
29MYB_26560356_Chip-Seq_TH1_Human2.27634915
30FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.21984171
31MAF_26560356_Chip-Seq_TH2_Human2.09295786
32ELF1_17652178_ChIP-ChIP_JURKAT_Human2.04150952
33BRD4_27068464_Chip-Seq_AML-cells_Mouse2.03140845
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.99221102
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.99199323
36MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.99046222
37TCF7_22412390_ChIP-Seq_EML_Mouse1.95267841
38GATA3_27048872_Chip-Seq_THYMUS_Human1.87993206
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.85103585
40KDM2B_26808549_Chip-Seq_SUP-B15_Human1.83380513
41FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.80282471
42EGR1_19374776_ChIP-ChIP_THP-1_Human1.79732780
43LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.74543985
44KDM2B_26808549_Chip-Seq_DND41_Human1.71691682
45KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.70639413
46LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.68773472
47SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.67243329
48KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.59079906
49TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.48412576
50RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.47589598
51CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.46227255
52GATA2_22383799_ChIP-Seq_G1ME_Mouse1.45993056
53GATA1_19941827_ChIP-Seq_MEL_Mouse1.45746729
54GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.43318983
55GATA3_26560356_Chip-Seq_TH2_Human1.43011614
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.38697066
57ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.37730103
58ELK3_25401928_ChIP-Seq_HUVEC_Human1.37667044
59TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36288875
60PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35239120
61VDR_24787735_ChIP-Seq_THP-1_Human1.33758459
62BCL6_27268052_Chip-Seq_Bcells_Human1.33661383
63CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33155797
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.31517343
65LXR_22292898_ChIP-Seq_THP-1_Human1.29449760
66GATA1_22383799_ChIP-Seq_G1ME_Mouse1.29325318
67PU.1_20513432_ChIP-Seq_Bcells_Mouse1.27212979
68PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26159670
69THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.24900977
70TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.24094600
71Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.23409224
72SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21092693
73CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20088183
74BCOR_27268052_Chip-Seq_Bcells_Human1.19259082
75NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.18899688
76GATA1_19941826_ChIP-Seq_K562_Human1.17752121
77VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.16858840
78GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14531352
79CIITA_25753668_ChIP-Seq_RAJI_Human1.14409045
80PU_27001747_Chip-Seq_BMDM_Mouse1.13191266
81CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12267539
82PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12252078
83KDM2B_26808549_Chip-Seq_JURKAT_Human1.11741029
84IKZF1_21737484_ChIP-ChIP_HCT116_Human1.11170882
85GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09245534
86ELF1_20517297_ChIP-Seq_JURKAT_Human1.06748581
87RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.06006387
88SMAD_19615063_ChIP-ChIP_OVARY_Human1.05133318
89STAT6_21828071_ChIP-Seq_BEAS2B_Human1.03988538
90GATA1_22025678_ChIP-Seq_K562_Human1.03503768
91RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00578892
92SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00566070
93CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00256898
94SPI1_20517297_ChIP-Seq_HL60_Human0.97753580
95NCOR1_26117541_ChIP-Seq_K562_Human0.96893815
96STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.95285826
97SA1_27219007_Chip-Seq_ERYTHROID_Human0.93642551
98P68_20966046_ChIP-Seq_HELA_Human0.91956989
99P300_27268052_Chip-Seq_Bcells_Human0.88451675
100GATA2_21666600_ChIP-Seq_HMVEC_Human0.86959691

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.62970548
2MP0003436_decreased_susceptibility_to4.35239657
3MP0001835_abnormal_antigen_presentation3.96785979
4MP0003303_peritoneal_inflammation3.41103597
5MP0005671_abnormal_response_to3.41101157
6MP0001800_abnormal_humoral_immune3.17423612
7MP0002419_abnormal_innate_immunity3.09767445
8MP0005000_abnormal_immune_tolerance3.06061896
9MP0000685_abnormal_immune_system3.02138419
10MP0005025_abnormal_response_to3.01136786
11MP0001790_abnormal_immune_system2.96228262
12MP0005387_immune_system_phenotype2.96228262
13MP0003763_abnormal_thymus_physiology2.92916519
14MP0009785_altered_susceptibility_to2.81730755
15MP0002723_abnormal_immune_serum2.79129351
16MP0002420_abnormal_adaptive_immunity2.78259958
17MP0001819_abnormal_immune_cell2.75098309
18MP0002452_abnormal_antigen_presenting2.65261529
19MP0002148_abnormal_hypersensitivity_rea2.35876557
20MP0006082_CNS_inflammation2.35702592
21MP0002398_abnormal_bone_marrow2.27175796
22MP0005464_abnormal_platelet_physiology2.25327250
23MP0003300_gastrointestinal_ulcer2.20143519
24MP0002405_respiratory_system_inflammati2.18221284
25MP0002396_abnormal_hematopoietic_system2.15141145
26MP0000716_abnormal_immune_system2.13565792
27MP0003191_abnormal_cellular_cholesterol2.07768371
28MP0001533_abnormal_skeleton_physiology2.06299719
29MP0009333_abnormal_splenocyte_physiolog1.99538871
30MP0010155_abnormal_intestine_physiology1.95421387
31MP0002132_abnormal_respiratory_system1.92562527
32MP0000689_abnormal_spleen_morphology1.88000623
33MP0003866_abnormal_defecation1.87647136
34MP0002722_abnormal_immune_system1.86625117
35MP0000465_gastrointestinal_hemorrhage1.86290730
36MP0001845_abnormal_inflammatory_respons1.79627631
37MP0009278_abnormal_bone_marrow1.77558015
38MP0000703_abnormal_thymus_morphology1.77419412
39MP0002429_abnormal_blood_cell1.72462397
40MP0004947_skin_inflammation1.68671459
41MP0008260_abnormal_autophagy1.67763368
42MP0008469_abnormal_protein_level1.48095329
43MP0003828_pulmonary_edema1.46332251
44MP0004381_abnormal_hair_follicle1.45688034
45MP0003183_abnormal_peptide_metabolism1.44170432
46MP0003172_abnormal_lysosome_physiology1.43482981
47MP0002277_abnormal_respiratory_mucosa1.35836749
48MP0005397_hematopoietic_system_phenotyp1.33118718
49MP0001545_abnormal_hematopoietic_system1.33118718
50MP0009764_decreased_sensitivity_to1.32747822
51MP0005310_abnormal_salivary_gland1.30948455
52MP0002166_altered_tumor_susceptibility1.29986744
53MP0001851_eye_inflammation1.28434734
54MP0005075_abnormal_melanosome_morpholog1.26044094
55MP0001873_stomach_inflammation1.25502926
56MP0000858_altered_metastatic_potential1.22917030
57MP0005451_abnormal_body_composition1.12448003
58MP0003075_altered_response_to1.07576184
59MP0004883_abnormal_blood_vessel1.06175672
60MP0002998_abnormal_bone_remodeling1.00411075
61MP0003806_abnormal_nucleotide_metabolis0.99973296
62MP0000490_abnormal_crypts_of0.97343329
63MP0004808_abnormal_hematopoietic_stem0.95337342
64MP0002933_joint_inflammation0.92483777
65MP0005166_decreased_susceptibility_to0.92004319
66MP0002138_abnormal_hepatobiliary_system0.89261698
67MP0009763_increased_sensitivity_to0.88463213
68MP0001986_abnormal_taste_sensitivity0.87007704
69MP0005390_skeleton_phenotype0.85880994
70MP0001663_abnormal_digestive_system0.85487437
71MP0004510_myositis0.85129058
72MP0002006_tumorigenesis0.83690679
73MP0001853_heart_inflammation0.82138660
74MP0005164_abnormal_response_to0.81055949
75MP0003045_fibrosis0.75104678
76MP0003448_altered_tumor_morphology0.73932835
77MP0002019_abnormal_tumor_incidence0.71471193
78MP0009765_abnormal_xenobiotic_induced0.68842241
79MP0005058_abnormal_lysosome_morphology0.68541662
80MP0003690_abnormal_glial_cell0.67616297
81MP0003656_abnormal_erythrocyte_physiolo0.63739926
82MP0000015_abnormal_ear_pigmentation0.63006494
83MP0000343_altered_response_to0.62268119
84MP0008004_abnormal_stomach_pH0.61650037
85MP0003795_abnormal_bone_structure0.61167039
86MP0002009_preneoplasia0.60841342
87MP0008874_decreased_physiological_sensi0.59102345
88MP0002928_abnormal_bile_duct0.56333775
89MP0000249_abnormal_blood_vessel0.55669793
90MP0004130_abnormal_muscle_cell0.55352340
91MP0005319_abnormal_enzyme/_coenzyme0.54084477
92MP0000604_amyloidosis0.51573680
93MP0002693_abnormal_pancreas_physiology0.51266103
94MP0003252_abnormal_bile_duct0.48009850
95MP0005377_hearing/vestibular/ear_phenot0.47489790
96MP0003878_abnormal_ear_physiology0.47489790
97MP0000609_abnormal_liver_physiology0.44876384
98MP0008873_increased_physiological_sensi0.44637720
99MP0005381_digestive/alimentary_phenotyp0.43332715
100MP0005083_abnormal_biliary_tract0.43058567

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.72645859
2Myositis (HP:0100614)5.86471396
3Recurrent abscess formation (HP:0002722)5.83980295
4Recurrent bacterial skin infections (HP:0005406)5.61253623
5Elevated erythrocyte sedimentation rate (HP:0003565)5.27707341
6Orchitis (HP:0100796)5.23388698
7Stomatitis (HP:0010280)5.15596704
8Abnormality of macrophages (HP:0004311)5.14263391
9Optic neuritis (HP:0100653)4.86957608
10Retrobulbar optic neuritis (HP:0100654)4.86957608
11Recurrent gram-negative bacterial infections (HP:0005420)4.70882072
12Abnormal delayed hypersensitivity skin test (HP:0002963)4.70761738
13Recurrent fungal infections (HP:0002841)4.45997494
14Meningitis (HP:0001287)4.44406699
15Obstructive lung disease (HP:0006536)4.39635620
16Chronic obstructive pulmonary disease (HP:0006510)4.39635620
17Mediastinal lymphadenopathy (HP:0100721)4.37389399
18Gastrointestinal infarctions (HP:0005244)4.15978319
19Encephalitis (HP:0002383)3.99417455
20Increased IgE level (HP:0003212)3.97257592
21Hypochromic microcytic anemia (HP:0004840)3.90217809
22Recurrent skin infections (HP:0001581)3.87319408
23Vasculitis (HP:0002633)3.77530450
24Urticaria (HP:0001025)3.67446241
25Hypochromic anemia (HP:0001931)3.67232043
26Chronic mucocutaneous candidiasis (HP:0002728)3.66982067
27Recurrent cutaneous fungal infections (HP:0011370)3.66982067
28Keratoconjunctivitis sicca (HP:0001097)3.58439658
29Panhypogammaglobulinemia (HP:0003139)3.56154568
30Prolonged bleeding time (HP:0003010)3.51209316
31Cellulitis (HP:0100658)3.50652527
32Spontaneous hematomas (HP:0007420)3.47769878
33T lymphocytopenia (HP:0005403)3.43319894
34Abnormality of T cell number (HP:0011839)3.41449516
35Chest pain (HP:0100749)3.38115621
36Keratoconjunctivitis (HP:0001096)3.35788856
37Abnormality of T cells (HP:0002843)3.32899237
38Gingivitis (HP:0000230)3.23701300
39Recurrent viral infections (HP:0004429)3.15858401
40Increased IgM level (HP:0003496)3.15683911
41Granulocytopenia (HP:0001913)3.11718446
42Leukocytosis (HP:0001974)3.09357677
43Inflammation of the large intestine (HP:0002037)3.06073488
44Abnormality of T cell physiology (HP:0011840)3.05905958
45Pulmonary infiltrates (HP:0002113)3.04742550
46Pustule (HP:0200039)3.04452691
47Episodic fever (HP:0001954)3.00738353
48Gastrointestinal inflammation (HP:0004386)3.00490654
49Agammaglobulinemia (HP:0004432)2.97897687
50IgM deficiency (HP:0002850)2.90483305
51Lymphopenia (HP:0001888)2.88559349
52Hemoptysis (HP:0002105)2.88161178
53Epistaxis (HP:0000421)2.85215953
54Petechiae (HP:0000967)2.81578237
55Gingival bleeding (HP:0000225)2.81507062
56Abnormality of cells of the lymphoid lineage (HP:0012140)2.74933054
57Arterial thrombosis (HP:0004420)2.72919047
58Anorexia (HP:0002039)2.69773986
59Pulmonary embolism (HP:0002204)2.66200746
60Osteomyelitis (HP:0002754)2.61483506
61Microcytic anemia (HP:0001935)2.61230869
62Hypergammaglobulinemia (HP:0010702)2.58604775
63Eosinophilia (HP:0001880)2.57920131
64Sepsis (HP:0100806)2.56222853
65Autoimmune hemolytic anemia (HP:0001890)2.53708585
66Abnormality of the pleura (HP:0002103)2.43827650
67Colitis (HP:0002583)2.41770713
68Recurrent bronchitis (HP:0002837)2.41015002
69Peritonitis (HP:0002586)2.33972192
70Gastrointestinal stroma tumor (HP:0100723)2.33632241
71Severe combined immunodeficiency (HP:0004430)2.29456774
72Abnormality of eosinophils (HP:0001879)2.28864770
73Gangrene (HP:0100758)2.25448639
74Recurrent sinusitis (HP:0011108)2.24102883
75Abnormality of the heme biosynthetic pathway (HP:0010472)2.23743296
76Abnormality of the peritoneum (HP:0002585)2.20433853
77Skin ulcer (HP:0200042)2.17190490
78IgG deficiency (HP:0004315)2.17102483
79Amyloidosis (HP:0011034)2.16764789
80Acute hepatic failure (HP:0006554)2.13892734
81Hepatosplenomegaly (HP:0001433)2.12862787
82Chronic otitis media (HP:0000389)2.11663462
83Verrucae (HP:0200043)2.11290446
84Papilloma (HP:0012740)2.11290446
85Skin rash (HP:0000988)2.09788077
86Glomerulopathy (HP:0100820)2.09160551
87Autoimmune thrombocytopenia (HP:0001973)2.08276255
88Purpura (HP:0000979)2.07107079
89Abnormality of B cell number (HP:0010975)2.04899016
90Recurrent pneumonia (HP:0006532)2.03944714
91Increased serum ferritin (HP:0003281)2.01879731
92Recurrent lower respiratory tract infections (HP:0002783)1.98068809
93Keratitis (HP:0000491)1.97764895
94Abnormality of iron homeostasis (HP:0011031)1.97441252
95Viral hepatitis (HP:0006562)1.96996550
96Premature loss of primary teeth (HP:0006323)1.96500385
97Abnormality of the pericardium (HP:0001697)1.95992429
98Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.94563260
99Joint swelling (HP:0001386)1.93361630
100Vertigo (HP:0002321)1.92655303

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.49391279
2RIPK44.44954336
3IRAK43.06973484
4ERN12.99861734
5FES2.89161614
6MAP2K32.78709787
7BLK2.73225048
8GRK62.71996702
9TNK22.63867561
10TYK22.57977855
11CSK2.51930938
12TXK2.32346264
13PRPF4B2.21367422
14ZAP702.15518586
15BTK2.11305560
16SYK1.93130429
17JAK31.91502412
18TAOK31.84858035
19HCK1.83978478
20EPHB11.78445362
21MAP3K111.72827511
22IKBKE1.68502741
23TAOK11.58785541
24MAP3K141.57528503
25KIT1.56601543
26MAP3K31.55765851
27TBK11.54898746
28TESK21.50970782
29LYN1.47124032
30CSF1R1.42277005
31ITK1.42048292
32LCK1.40731676
33MAP3K131.39797372
34SIK31.33198911
35FGR1.31166750
36JAK11.28231673
37JAK21.28000400
38TEC1.16295165
39CDK191.15948083
40MAP3K11.15228979
41MARK31.12681809
42PRKD21.00871475
43IKBKB0.99115486
44KSR20.94095841
45STK100.93825426
46SMG10.93188333
47SIK20.92031848
48TAOK20.89703882
49PDK10.87441342
50TRIB30.85428531
51MATK0.84585629
52MARK20.83829019
53YES10.83708033
54PTK60.82381155
55KDR0.77503166
56BMPR20.77212389
57IRAK10.73557099
58LRRK20.72721246
59FYN0.70367297
60MAPK120.69529974
61MAP3K70.69130787
62PDPK10.63263322
63PIM10.61617893
64HIPK20.57943685
65MAP2K20.56938358
66IRAK20.56708787
67* PRKCQ0.56475215
68PTK2B0.53722081
69MAPK70.52288768
70DYRK1B0.50826779
71PIK3CG0.50125614
72STK110.48694059
73MAP3K60.47888752
74FGFR40.47509803
75NLK0.45910464
76RPS6KC10.45551148
77RPS6KL10.45551148
78CAMKK10.44208281
79MAP3K50.43344726
80MAP2K60.42298398
81PRKCH0.40103134
82RPS6KA60.39897033
83FGFR30.39811572
84MAPKAPK20.39155007
85RAF10.39003662
86CDK40.38141803
87MAP2K40.37316075
88SIK10.36745163
89STK380.36214392
90MAPK110.36175704
91RET0.35797012
92CDC42BPA0.33866571
93PRKG20.33483749
94EPHA30.33293964
95TGFBR20.32744886
96DAPK20.31692381
97PRKCD0.29853750
98BCKDK0.28816384
99SGK30.26039305
100ALK0.23602718

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.26952309
2Graft-versus-host disease_Homo sapiens_hsa053323.17853882
3Allograft rejection_Homo sapiens_hsa053303.11565607
4Leishmaniasis_Homo sapiens_hsa051403.05755195
5Autoimmune thyroid disease_Homo sapiens_hsa053202.95357846
6Osteoclast differentiation_Homo sapiens_hsa043802.81893569
7Staphylococcus aureus infection_Homo sapiens_hsa051502.71134766
8Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.64489473
9B cell receptor signaling pathway_Homo sapiens_hsa046622.42221835
10Type I diabetes mellitus_Homo sapiens_hsa049402.33482744
11Antigen processing and presentation_Homo sapiens_hsa046122.17830763
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.08365565
13Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.01683466
14Tuberculosis_Homo sapiens_hsa051521.99585525
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.97040876
16T cell receptor signaling pathway_Homo sapiens_hsa046601.93230419
17Hematopoietic cell lineage_Homo sapiens_hsa046401.92437785
18Viral myocarditis_Homo sapiens_hsa054161.92381416
19Measles_Homo sapiens_hsa051621.90069057
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.83135041
21Acute myeloid leukemia_Homo sapiens_hsa052211.81259931
22Asthma_Homo sapiens_hsa053101.77581183
23Malaria_Homo sapiens_hsa051441.76286420
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.75567581
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.74145199
26Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.63062406
27Herpes simplex infection_Homo sapiens_hsa051681.60679010
28Chemokine signaling pathway_Homo sapiens_hsa040621.58771487
29Toxoplasmosis_Homo sapiens_hsa051451.52110384
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.50424276
31Influenza A_Homo sapiens_hsa051641.48613778
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.38208858
33Legionellosis_Homo sapiens_hsa051341.27313421
34African trypanosomiasis_Homo sapiens_hsa051431.27005009
35Non-small cell lung cancer_Homo sapiens_hsa052231.19389195
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.19050525
37Phagosome_Homo sapiens_hsa041451.18725159
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.18522488
39Leukocyte transendothelial migration_Homo sapiens_hsa046701.17970866
40Platelet activation_Homo sapiens_hsa046111.16119731
41TNF signaling pathway_Homo sapiens_hsa046681.15613298
42Hepatitis B_Homo sapiens_hsa051611.09882096
43Rheumatoid arthritis_Homo sapiens_hsa053231.01462781
44Shigellosis_Homo sapiens_hsa051311.01255244
45Other glycan degradation_Homo sapiens_hsa005111.00438725
46Hepatitis C_Homo sapiens_hsa051600.96570137
47Apoptosis_Homo sapiens_hsa042100.93453335
48Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.92687469
49Pancreatic cancer_Homo sapiens_hsa052120.91436583
50Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.88440746
51Epstein-Barr virus infection_Homo sapiens_hsa051690.86187459
52* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86095308
53Chronic myeloid leukemia_Homo sapiens_hsa052200.85260986
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.84652613
55Pertussis_Homo sapiens_hsa051330.84247365
56VEGF signaling pathway_Homo sapiens_hsa043700.81083578
57Salmonella infection_Homo sapiens_hsa051320.79176807
58SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75805010
59Viral carcinogenesis_Homo sapiens_hsa052030.73427115
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70777790
61Endocytosis_Homo sapiens_hsa041440.69811186
62Prolactin signaling pathway_Homo sapiens_hsa049170.67410295
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67049320
64HTLV-I infection_Homo sapiens_hsa051660.66624989
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.62035795
66Regulation of autophagy_Homo sapiens_hsa041400.58458927
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58164409
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57292908
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.57152295
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.55650083
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52232489
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51417927
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.50894517
74Renal cell carcinoma_Homo sapiens_hsa052110.50236119
75Choline metabolism in cancer_Homo sapiens_hsa052310.50213620
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50125493
77FoxO signaling pathway_Homo sapiens_hsa040680.50113264
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.48779139
79Notch signaling pathway_Homo sapiens_hsa043300.48154007
80Colorectal cancer_Homo sapiens_hsa052100.48152974
81AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45690823
82Lysosome_Homo sapiens_hsa041420.44764729
83Endometrial cancer_Homo sapiens_hsa052130.42447905
84MAPK signaling pathway_Homo sapiens_hsa040100.40835527
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.40124261
86Inositol phosphate metabolism_Homo sapiens_hsa005620.39099108
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38866696
88Insulin resistance_Homo sapiens_hsa049310.37010939
89mTOR signaling pathway_Homo sapiens_hsa041500.36446754
90Systemic lupus erythematosus_Homo sapiens_hsa053220.35075935
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34746357
92HIF-1 signaling pathway_Homo sapiens_hsa040660.32588833
93GnRH signaling pathway_Homo sapiens_hsa049120.31543455
94Amoebiasis_Homo sapiens_hsa051460.31120775
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28868497
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.28097587
97Rap1 signaling pathway_Homo sapiens_hsa040150.27961029
98Glycosaminoglycan degradation_Homo sapiens_hsa005310.27461374
99Dorso-ventral axis formation_Homo sapiens_hsa043200.27244084
100Arachidonic acid metabolism_Homo sapiens_hsa005900.21353358

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