ICAM4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the Landsteiner-Wiener (LW) blood group antigen(s) that belongs to the immunoglobulin (Ig) superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. This ICAM protein contains 2 Ig-like C2-type domains and binds to the leukocyte adhesion LFA-1 protein. The molecular basis of the LW(A)/LW(B) blood group antigens is a single aa variation at position 100; Gln-100=LW(A) and Arg-100=LW(B). Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1heme biosynthetic process (GO:0006783)8.68554102
2porphyrin-containing compound biosynthetic process (GO:0006779)8.20175324
3tetrapyrrole biosynthetic process (GO:0033014)7.34416322
4heme metabolic process (GO:0042168)6.95853176
5porphyrin-containing compound metabolic process (GO:0006778)6.55573759
6erythrocyte maturation (GO:0043249)6.07622287
7ribosomal small subunit assembly (GO:0000028)5.58679715
8erythrocyte development (GO:0048821)5.33546918
9DNA deamination (GO:0045006)4.87956519
10DNA strand elongation involved in DNA replication (GO:0006271)4.78878033
11telomere maintenance via semi-conservative replication (GO:0032201)4.72791379
12DNA replication initiation (GO:0006270)4.59995368
13DNA strand elongation (GO:0022616)4.59995089
14viral transcription (GO:0019083)4.58473370
15translational termination (GO:0006415)4.40818050
16tetrapyrrole metabolic process (GO:0033013)4.36591314
17pigment biosynthetic process (GO:0046148)4.34973752
18deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.23107125
19proteasome assembly (GO:0043248)4.04771540
20translational elongation (GO:0006414)4.03978830
21telomere maintenance via recombination (GO:0000722)3.97171275
22one-carbon compound transport (GO:0019755)3.88734805
23regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.85596660
24DNA replication checkpoint (GO:0000076)3.83586692
25ribosomal small subunit biogenesis (GO:0042274)3.83275975
26SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.81221602
27erythrocyte differentiation (GO:0030218)3.79232777
28regulation of T-helper 1 cell differentiation (GO:0045625)3.74752046
29cotranslational protein targeting to membrane (GO:0006613)3.71889527
30protein targeting to ER (GO:0045047)3.70513892
31DNA unwinding involved in DNA replication (GO:0006268)3.70169440
32myeloid cell development (GO:0061515)3.69405478
33hemoglobin metabolic process (GO:0020027)3.69079999
34maturation of SSU-rRNA (GO:0030490)3.66838923
35immunoglobulin mediated immune response (GO:0016064)3.65250600
36pigment metabolic process (GO:0042440)3.64256603
37CENP-A containing nucleosome assembly (GO:0034080)3.60715021
38mitotic recombination (GO:0006312)3.60553911
39oxygen transport (GO:0015671)3.60192192
40embryonic hemopoiesis (GO:0035162)3.59659433
41negative regulation of erythrocyte differentiation (GO:0045647)3.57401529
42translational initiation (GO:0006413)3.56981916
43establishment of protein localization to endoplasmic reticulum (GO:0072599)3.54419474
44nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.52978077
45protein localization to endoplasmic reticulum (GO:0070972)3.50892597
46purine nucleotide salvage (GO:0032261)3.48725276
47cellular protein complex disassembly (GO:0043624)3.47925736
48viral life cycle (GO:0019058)3.40804743
49response to interferon-beta (GO:0035456)3.40724397
50positive regulation of megakaryocyte differentiation (GO:0045654)3.40357039
51telomere maintenance via telomere lengthening (GO:0010833)3.39538985
52response to protozoan (GO:0001562)3.35317240
53chromatin remodeling at centromere (GO:0031055)3.34372215
54granulocyte differentiation (GO:0030851)3.34222100
55gas transport (GO:0015669)3.33976820
56response to peptidoglycan (GO:0032494)3.33781467
57positive regulation of gamma-delta T cell activation (GO:0046645)3.28111817
58positive regulation of B cell differentiation (GO:0045579)3.27841047
59positive regulation of antigen processing and presentation (GO:0002579)3.26891618
60DNA replication-independent nucleosome assembly (GO:0006336)3.22729779
61DNA replication-independent nucleosome organization (GO:0034724)3.22729779
62purine-containing compound salvage (GO:0043101)3.22330765
63response to lead ion (GO:0010288)3.14783237
64kinetochore organization (GO:0051383)3.14251470
65protein complex disassembly (GO:0043241)3.10934871
66regulation of erythrocyte differentiation (GO:0045646)3.10385768
67DNA replication-dependent nucleosome organization (GO:0034723)3.07843635
68DNA replication-dependent nucleosome assembly (GO:0006335)3.07843635
69regulation of chronic inflammatory response (GO:0002676)3.07735320
70formation of translation preinitiation complex (GO:0001731)3.07480879
71cellular response to interferon-beta (GO:0035458)3.06878516
72nucleotide-excision repair, DNA gap filling (GO:0006297)3.06864855
73negative regulation of interleukin-12 production (GO:0032695)3.05374507
74ribosomal large subunit biogenesis (GO:0042273)3.04123003
75neutrophil activation involved in immune response (GO:0002283)3.04044859
76positive regulation of heat generation (GO:0031652)3.03545613
77response to insecticide (GO:0017085)3.03512361
78iron-sulfur cluster assembly (GO:0016226)3.02993890
79metallo-sulfur cluster assembly (GO:0031163)3.02993890
80protein localization to chromosome, centromeric region (GO:0071459)3.01935813
81kinetochore assembly (GO:0051382)3.01504954
82response to methylmercury (GO:0051597)2.99894066
83pseudouridine synthesis (GO:0001522)2.97446827
84positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.97316401
85definitive hemopoiesis (GO:0060216)2.96196328
86pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.96182527
87protein localization to kinetochore (GO:0034501)2.95373896
88ribonucleoprotein complex biogenesis (GO:0022613)2.94581820
89mitotic sister chromatid segregation (GO:0000070)2.94139872
90NAD biosynthetic process (GO:0009435)2.93048131
91macromolecular complex disassembly (GO:0032984)2.91464686
92attachment of spindle microtubules to kinetochore (GO:0008608)2.91418581
93defense response to protozoan (GO:0042832)2.91385476
94translation (GO:0006412)2.90541426
95regulation of B cell apoptotic process (GO:0002902)2.89689888
96IMP biosynthetic process (GO:0006188)2.88076167
97B cell mediated immunity (GO:0019724)2.87678418
98deoxyribonucleotide biosynthetic process (GO:0009263)2.87037499
99lipopolysaccharide-mediated signaling pathway (GO:0031663)2.86727145
100positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.86309674
101regulation of antigen processing and presentation (GO:0002577)2.86028425
102negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.85668031
103positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.85125171
104negative regulation of nitric oxide biosynthetic process (GO:0045019)2.82363012
105megakaryocyte development (GO:0035855)2.82175903
106positive regulation of chemokine biosynthetic process (GO:0045080)2.82036381
107positive regulation of natural killer cell differentiation (GO:0032825)2.82011621
108positive regulation of T-helper cell differentiation (GO:0045624)2.81743382
109folic acid-containing compound biosynthetic process (GO:0009396)2.81407827
110cellular response to exogenous dsRNA (GO:0071360)2.79958092
111regulation of chemokine biosynthetic process (GO:0045073)2.78449067
112regulation of dendritic cell antigen processing and presentation (GO:0002604)2.78314449
113positive regulation of erythrocyte differentiation (GO:0045648)2.78175881
114rRNA processing (GO:0006364)2.75490367
115positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.75430517
116nuclear-transcribed mRNA catabolic process (GO:0000956)2.75412395
117deoxyribose phosphate biosynthetic process (GO:0046385)2.75133924
1182-deoxyribonucleotide biosynthetic process (GO:0009265)2.75133924
119histone exchange (GO:0043486)2.72240937
120platelet formation (GO:0030220)2.71861659
121regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.71387083
122meiotic chromosome segregation (GO:0045132)2.71089194
123cellular response to thyroid hormone stimulus (GO:0097067)2.70357446
124positive regulation of prostaglandin secretion (GO:0032308)2.70131808
125rRNA metabolic process (GO:0016072)2.69126605
126RNA catabolic process (GO:0006401)2.64283953
127regulation of response to osmotic stress (GO:0047484)2.64195089
128positive regulation of defense response to virus by host (GO:0002230)2.64180767
129maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.63037607
130superoxide anion generation (GO:0042554)2.62443626
131regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.62376389
132anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.62180043
133cell cycle G1/S phase transition (GO:0044843)2.61951074
134G1/S transition of mitotic cell cycle (GO:0000082)2.61951074
135mRNA catabolic process (GO:0006402)2.61293460
136ribosome biogenesis (GO:0042254)2.60847065
137pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.60645260
138positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.60641104
139indole-containing compound catabolic process (GO:0042436)2.60639430
140indolalkylamine catabolic process (GO:0046218)2.60639430
141tryptophan catabolic process (GO:0006569)2.60639430
142telomere organization (GO:0032200)2.60112995
143negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.59961466
144folic acid metabolic process (GO:0046655)2.59841396
145telomere maintenance (GO:0000723)2.59270923
146nucleobase biosynthetic process (GO:0046112)2.59222174
147NIK/NF-kappaB signaling (GO:0038061)2.56641725
148regulation of vitamin D biosynthetic process (GO:0060556)2.56363710
149deoxyribonucleotide catabolic process (GO:0009264)2.56069200
150positive regulation of T-helper 1 type immune response (GO:0002827)2.56045644
151nucleotide salvage (GO:0043173)2.55814534
152mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.54896367
153mitochondrial respiratory chain complex I assembly (GO:0032981)2.54896367
154NADH dehydrogenase complex assembly (GO:0010257)2.54896367
155protein complex biogenesis (GO:0070271)2.53729004
156regulation of mast cell degranulation (GO:0043304)2.52500559
157Peyers patch development (GO:0048541)2.52332979
158mucosal-associated lymphoid tissue development (GO:0048537)2.52332979
159negative regulation of cytokine production involved in immune response (GO:0002719)2.51247965
160purine deoxyribonucleotide catabolic process (GO:0009155)2.51164185
161amine catabolic process (GO:0009310)2.50649147
162cellular biogenic amine catabolic process (GO:0042402)2.50649147
163positive regulation of granulocyte differentiation (GO:0030854)2.49678752
164positive regulation of NF-kappaB import into nucleus (GO:0042346)2.49022080
165mature B cell differentiation involved in immune response (GO:0002313)2.48672383
166positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.48574552
167regulation of T-helper cell differentiation (GO:0045622)2.47056408
168response to ATP (GO:0033198)2.45346122
169autophagic vacuole fusion (GO:0000046)2.44725746
170regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.44665395
171regulation of fever generation (GO:0031620)2.44577405
172type I interferon signaling pathway (GO:0060337)2.44185857
173cellular response to type I interferon (GO:0071357)2.44185857
174kynurenine metabolic process (GO:0070189)2.43419022
175response to type I interferon (GO:0034340)2.42675415
176germinal center formation (GO:0002467)2.42001563
177positive regulation of interleukin-1 beta secretion (GO:0050718)2.41952537
178tryptophan metabolic process (GO:0006568)2.41261148
179regulation of mast cell activation involved in immune response (GO:0033006)2.40801147
180regulation of mast cell activation (GO:0033003)2.40209721
181purinergic nucleotide receptor signaling pathway (GO:0035590)2.39650897
182deoxyribose phosphate catabolic process (GO:0046386)2.37200796
183regulation of interferon-alpha production (GO:0032647)2.36721793
184protoporphyrinogen IX metabolic process (GO:0046501)11.0575889
185protoporphyrinogen IX biosynthetic process (GO:0006782)10.5774095

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.79828332
2* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse5.12645762
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.46677240
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.39674395
5GATA1_22025678_ChIP-Seq_K562_Human3.31370573
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.24212606
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.20185997
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.74802845
9SCL_19346495_ChIP-Seq_HPC-7_Human2.71112764
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.65052337
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.63263020
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.50878876
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.50314994
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.49240246
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.46718486
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.39950961
17SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.35703437
18TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.34295517
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.30488080
20TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.27767640
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.24012695
22* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.17215958
23VDR_23849224_ChIP-Seq_CD4+_Human2.14849611
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.11866879
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.11089515
26* GATA1_19941827_ChIP-Seq_MEL_Mouse2.09059810
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.05004774
28* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.04070481
29* GATA1_22383799_ChIP-Seq_G1ME_Mouse2.00919004
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.98845883
31XRN2_22483619_ChIP-Seq_HELA_Human1.92278620
32THAP11_20581084_ChIP-Seq_MESCs_Mouse1.90835123
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.88660839
34GATA1_19941826_ChIP-Seq_K562_Human1.86832325
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.85974639
36FOXP3_21729870_ChIP-Seq_TREG_Human1.85055963
37STAT4_19710469_ChIP-ChIP_TH1__Mouse1.84284424
38FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.83467473
39HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.77605918
40E2F1_21310950_ChIP-Seq_MCF-7_Human1.75724621
41DCP1A_22483619_ChIP-Seq_HELA_Human1.74903809
42MYC_22102868_ChIP-Seq_BL_Human1.73818985
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.72810227
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.72192258
45E2F1_18555785_ChIP-Seq_MESCs_Mouse1.70530582
46* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.70315577
47KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.68496768
48* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.67502480
49GABP_19822575_ChIP-Seq_HepG2_Human1.65913973
50* NCOR1_26117541_ChIP-Seq_K562_Human1.64002909
51CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.63396771
52AR_21909140_ChIP-Seq_LNCAP_Human1.62748575
53SPI1_23127762_ChIP-Seq_K562_Human1.59593467
54BCL6_27268052_Chip-Seq_Bcells_Human1.57241505
55IRF8_27001747_Chip-Seq_BMDM_Mouse1.56947101
56VDR_21846776_ChIP-Seq_THP-1_Human1.55233783
57ELF1_20517297_ChIP-Seq_JURKAT_Human1.53214967
58RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.50553215
59SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.49890208
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.49560156
61FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49097830
62CIITA_25753668_ChIP-Seq_RAJI_Human1.47754876
63MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.47176766
64MYB_26560356_Chip-Seq_TH2_Human1.45080594
65RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.44655372
66TTF2_22483619_ChIP-Seq_HELA_Human1.42583579
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40114061
68SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.37824218
69PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36376962
70STAT1_20625510_ChIP-Seq_HELA_Human1.35381914
71VDR_24763502_ChIP-Seq_THP-1_Human1.34414457
72MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.33406801
73NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.32979060
74YY1_21170310_ChIP-Seq_MESCs_Mouse1.32970554
75* BCOR_27268052_Chip-Seq_Bcells_Human1.32558545
76NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.31360789
77MYCN_18555785_ChIP-Seq_MESCs_Mouse1.31126968
78MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.30003703
79* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29416329
80E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.27776042
81PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.27195012
82UTX_26944678_Chip-Seq_JUKART_Human1.26829078
83CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.26347790
84* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26183889
85ELK1_19687146_ChIP-ChIP_HELA_Human1.25144122
86* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.24137704
87KDM5A_27292631_Chip-Seq_BREAST_Human1.23148575
88PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.22322166
89SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22171365
90MYB_21317192_ChIP-Seq_ERMYB_Mouse1.22039144
91LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.20873121
92LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.20614163
93YY1_22570637_ChIP-Seq_MALME-3M_Human1.19828092
94SPI1_23547873_ChIP-Seq_NB4_Human1.16912543
95NANOG_18555785_ChIP-Seq_MESCs_Mouse1.16773532
96E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16764869
97FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16538436
98* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.16333107
99MYB_26560356_Chip-Seq_TH1_Human1.16080755
100P300_27268052_Chip-Seq_Bcells_Human1.15265311
101CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.13380230
102MAF_26560356_Chip-Seq_TH2_Human1.13190842
103POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.13184770
104ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.12932434
105ZNF274_21170338_ChIP-Seq_K562_Hela1.09177505
106GATA3_26560356_Chip-Seq_TH2_Human1.08951835
107CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.08576599
108RUNX1_22412390_ChIP-Seq_EML_Mouse1.07604337
109TFEB_21752829_ChIP-Seq_HELA_Human1.05880526
110YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05841195
111GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.05119840
112TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04697813
113VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.04621421
114HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.02937869
115STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.02071728
116NOTCH1_21737748_ChIP-Seq_TLL_Human1.01166788
117IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.01127697
118DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99981079
119* E2F1_20622854_ChIP-Seq_HELA_Human0.99849036
120EGR1_19374776_ChIP-ChIP_THP-1_Human0.99440340
121CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.99151633
122GATA2_19941826_ChIP-Seq_K562_Human0.99113127
123CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99060198
124CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.98349351
125STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.97834125
126BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96276740
127CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.94857395
128CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.94822201
129STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94515745
130GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.92914272
131KLF4_18555785_ChIP-Seq_MESCs_Mouse0.92524901
132IRF8_22096565_ChIP-ChIP_GC-B_Human0.92021052
133MAF_26560356_Chip-Seq_TH1_Human0.90542643
134ZNF263_19887448_ChIP-Seq_K562_Human0.88667529
135HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.88343246
136MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.87601457

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo8.52452645
2MP0004147_increased_porphyrin_level8.31764413
3MP0003303_peritoneal_inflammation4.18697152
4MP0003111_abnormal_nucleus_morphology3.74957772
5MP0003693_abnormal_embryo_hatching3.49123812
6MP0001545_abnormal_hematopoietic_system3.43117344
7MP0005397_hematopoietic_system_phenotyp3.43117344
8MP0002396_abnormal_hematopoietic_system3.39228542
9MP0010094_abnormal_chromosome_stability3.24714738
10MP0002148_abnormal_hypersensitivity_rea2.86574386
11MP0003077_abnormal_cell_cycle2.73509423
12MP0003436_decreased_susceptibility_to2.64606000
13MP0004957_abnormal_blastocyst_morpholog2.58660864
14MP0008057_abnormal_DNA_replication2.43084574
15MP0006082_CNS_inflammation2.23205370
16MP0008058_abnormal_DNA_repair2.12939208
17MP0006054_spinal_hemorrhage2.08567318
18MP0000490_abnormal_crypts_of2.05077909
19MP0002132_abnormal_respiratory_system2.04731332
20MP0005058_abnormal_lysosome_morphology1.97521220
21MP0006036_abnormal_mitochondrial_physio1.95684585
22MP0005464_abnormal_platelet_physiology1.93737821
23MP0002398_abnormal_bone_marrow1.80533695
24MP0001790_abnormal_immune_system1.78252161
25MP0005387_immune_system_phenotype1.78252161
26MP0002254_reproductive_system_inflammat1.78161266
27MP0004808_abnormal_hematopoietic_stem1.78014622
28MP0008007_abnormal_cellular_replicative1.69186932
29MP0003186_abnormal_redox_activity1.66655390
30MP0005636_abnormal_mineral_homeostasis1.64898723
31MP0005083_abnormal_biliary_tract1.61633043
32MP0000689_abnormal_spleen_morphology1.59310182
33MP0002722_abnormal_immune_system1.58187950
34MP0000685_abnormal_immune_system1.57549115
35MP0009333_abnormal_splenocyte_physiolog1.57007454
36MP0003806_abnormal_nucleotide_metabolis1.56103527
37MP0005167_abnormal_blood-brain_barrier1.55459477
38MP0003195_calcinosis1.48509068
39MP0000343_altered_response_to1.43215385
40MP0000465_gastrointestinal_hemorrhage1.39244764
41MP0002138_abnormal_hepatobiliary_system1.39062415
42* MP0002429_abnormal_blood_cell1.38238169
43MP0008004_abnormal_stomach_pH1.35911168
44MP0005671_abnormal_response_to1.34542060
45MP0008995_early_reproductive_senescence1.33513709
46MP0000313_abnormal_cell_death1.33494441
47MP0003075_altered_response_to1.33127692
48MP0001845_abnormal_inflammatory_respons1.29146398
49MP0008932_abnormal_embryonic_tissue1.25645813
50MP0001533_abnormal_skeleton_physiology1.25300389
51MP0005646_abnormal_pituitary_gland1.23058637
52MP0000350_abnormal_cell_proliferation1.22229744
53MP0002019_abnormal_tumor_incidence1.21550014
54MP0000372_irregular_coat_pigmentation1.21421454
55MP0005410_abnormal_fertilization1.20045183
56MP0005075_abnormal_melanosome_morpholog1.15373818
57MP0003786_premature_aging1.14792392
58MP0004510_myositis1.14588386
59MP0009379_abnormal_foot_pigmentation1.14284310
60MP0003724_increased_susceptibility_to1.10590910
61MP0005451_abnormal_body_composition1.10118009
62MP0005174_abnormal_tail_pigmentation1.09483580
63MP0000703_abnormal_thymus_morphology1.09070372
64MP0002095_abnormal_skin_pigmentation1.08540386
65MP0010307_abnormal_tumor_latency1.07523853
66MP0005084_abnormal_gallbladder_morpholo1.06098794
67MP0008775_abnormal_heart_ventricle1.04578948
68MP0005310_abnormal_salivary_gland1.03695612
69MP0003191_abnormal_cellular_cholesterol1.01441345
70MP0000716_abnormal_immune_system1.00786419
71MP0004947_skin_inflammation0.99889224
72MP0001835_abnormal_antigen_presentation0.99321085
73MP0003567_abnormal_fetal_cardiomyocyte0.97724218
74MP0001730_embryonic_growth_arrest0.96279048
75MP0001764_abnormal_homeostasis0.93288128
76MP0001663_abnormal_digestive_system0.92863092
77MP0002080_prenatal_lethality0.92709692
78MP0008872_abnormal_physiological_respon0.91827420
79MP0005025_abnormal_response_to0.91630060
80MP0005535_abnormal_body_temperature0.91269141
81MP0002837_dystrophic_cardiac_calcinosis0.91064590
82MP0003763_abnormal_thymus_physiology0.89325727
83MP0001853_heart_inflammation0.89060607
84MP0003300_gastrointestinal_ulcer0.88347890
85MP0002332_abnormal_exercise_endurance0.87911289
86MP0000358_abnormal_cell_content/0.87680423
87MP0005266_abnormal_metabolism0.87401099
88MP0003646_muscle_fatigue0.87296437
89MP0008260_abnormal_autophagy0.83837794
90MP0002420_abnormal_adaptive_immunity0.83576557
91MP0008770_decreased_survivor_rate0.82883439
92MP0001819_abnormal_immune_cell0.82479544
93MP0009931_abnormal_skin_appearance0.82398812
94MP0005166_decreased_susceptibility_to0.81545093
95MP0006035_abnormal_mitochondrial_morpho0.79710654
96MP0002405_respiratory_system_inflammati0.79665657
97MP0001501_abnormal_sleep_pattern0.79346966
98MP0008875_abnormal_xenobiotic_pharmacok0.76484167
99MP0009785_altered_susceptibility_to0.76231298
100MP0001800_abnormal_humoral_immune0.75942769
101MP0001986_abnormal_taste_sensitivity0.74882326
102MP0002723_abnormal_immune_serum0.74159773
103MP0004215_abnormal_myocardial_fiber0.73787902
104MP0008469_abnormal_protein_level0.73623105
105MP0001697_abnormal_embryo_size0.73265588
106MP0003866_abnormal_defecation0.72701030
107MP0000598_abnormal_liver_morphology0.72651362
108MP0009840_abnormal_foam_cell0.72168565
109MP0002452_abnormal_antigen_presenting0.71970322
110MP0000749_muscle_degeneration0.71164549
111MP0009764_decreased_sensitivity_to0.70912099
112MP0002166_altered_tumor_susceptibility0.70260558
113MP0005165_increased_susceptibility_to0.69155838
114MP0000604_amyloidosis0.69029858
115MP0008877_abnormal_DNA_methylation0.68910697
116MP0009278_abnormal_bone_marrow0.68609776
117MP0005647_abnormal_sex_gland0.68074828
118MP0001919_abnormal_reproductive_system0.67901837
119MP0003718_maternal_effect0.67526907
120MP0002086_abnormal_extraembryonic_tissu0.66355211
121MP0005000_abnormal_immune_tolerance0.65860322
122MP0006292_abnormal_olfactory_placode0.65081785
123MP0002102_abnormal_ear_morphology0.63780099
124MP0002139_abnormal_hepatobiliary_system0.63744755
125MP0005319_abnormal_enzyme/_coenzyme0.63685555
126MP0009763_increased_sensitivity_to0.63447258
127MP0010352_gastrointestinal_tract_polyps0.62233839
128MP0000015_abnormal_ear_pigmentation0.61638435
129MP0000609_abnormal_liver_physiology0.61250824
130MP0001529_abnormal_vocalization0.60440844
131MP0002419_abnormal_innate_immunity0.58643036
132MP0003172_abnormal_lysosome_physiology0.58572713
133MP0005384_cellular_phenotype0.58507307
134MP0005621_abnormal_cell_physiology0.58492238
135MP0009765_abnormal_xenobiotic_induced0.56778205
136MP0010155_abnormal_intestine_physiology0.55645525
137MP0001873_stomach_inflammation0.55453976
138MP0001672_abnormal_embryogenesis/_devel0.54797300
139MP0005380_embryogenesis_phenotype0.54797300
140MP0000858_altered_metastatic_potential0.52912776

Predicted human phenotypes

RankGene SetZ-score
1Poikilocytosis (HP:0004447)8.46452477
2Abnormal number of erythroid precursors (HP:0012131)7.30086988
3Abnormality of cells of the erythroid lineage (HP:0012130)6.95653401
4Acanthocytosis (HP:0001927)6.59793318
5Reticulocytosis (HP:0001923)6.05542757
6Petechiae (HP:0000967)5.23865646
7Abnormality of reticulocytes (HP:0004312)5.13227046
8Hyperbilirubinemia (HP:0002904)4.34524100
9Prolonged bleeding time (HP:0003010)4.26409078
10Birth length less than 3rd percentile (HP:0003561)4.23226050
11Hypochromic microcytic anemia (HP:0004840)4.22265137
12Diaphragmatic weakness (HP:0009113)4.19357376
13Paralysis (HP:0003470)4.00633171
14Stomatitis (HP:0010280)3.94779453
15Abnormality of liposaccharide metabolism (HP:0010968)3.89599126
16Abnormality of glycosphingolipid metabolism (HP:0004343)3.89599126
17Abnormality of glycolipid metabolism (HP:0010969)3.89599126
18Cholelithiasis (HP:0001081)3.87153828
19Pallor (HP:0000980)3.84316142
20Aplastic anemia (HP:0001915)3.83017900
21Increased serum ferritin (HP:0003281)3.57626665
22Reticulocytopenia (HP:0001896)3.49110226
23Macrocytic anemia (HP:0001972)3.47702769
24Abnormal gallbladder morphology (HP:0012437)3.38830905
25Microcytic anemia (HP:0001935)3.34488782
26Cutaneous photosensitivity (HP:0000992)3.32976550
27Polycythemia (HP:0001901)3.12927015
28Elevated erythrocyte sedimentation rate (HP:0003565)3.09441855
29Epistaxis (HP:0000421)3.05297725
30Abnormality of iron homeostasis (HP:0011031)3.04387011
31Hypochromic anemia (HP:0001931)3.02892793
32Insomnia (HP:0100785)2.92139727
33Abnormal hemoglobin (HP:0011902)2.90829674
34Purpura (HP:0000979)2.88941374
35Increased cerebral lipofuscin (HP:0011813)2.88207937
36Short middle phalanx of the 5th finger (HP:0004220)2.86553764
37Vacuolated lymphocytes (HP:0001922)2.86389984
38Myositis (HP:0100614)2.83819029
39Chronic obstructive pulmonary disease (HP:0006510)2.78493814
40Obstructive lung disease (HP:0006536)2.78493814
41Hypertensive crisis (HP:0100735)2.74246625
42Increased neuronal autofluorescent lipopigment (HP:0002074)2.73116090
43Abnormality of transition element cation homeostasis (HP:0011030)2.71275639
44Ileus (HP:0002595)2.67312748
45Acute necrotizing encephalopathy (HP:0006965)2.64999954
46Acute encephalopathy (HP:0006846)2.63872412
47Nausea (HP:0002018)2.63641378
48Autoimmune thrombocytopenia (HP:0001973)2.62639312
49Abnormal platelet function (HP:0011869)2.60803793
50Impaired platelet aggregation (HP:0003540)2.60803793
51Abnormal mitochondria in muscle tissue (HP:0008316)2.60600774
52Increased CSF lactate (HP:0002490)2.59510262
53Decreased activity of mitochondrial respiratory chain (HP:0008972)2.58157240
54Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.58157240
55Retrobulbar optic neuritis (HP:0100654)2.50116536
56Optic neuritis (HP:0100653)2.50116536
57Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.43402048
58Renal Fanconi syndrome (HP:0001994)2.39073062
59Abnormality of macrophages (HP:0004311)2.38597247
60Orchitis (HP:0100796)2.38483825
61Recurrent abscess formation (HP:0002722)2.36589056
62Hyperthyroidism (HP:0000836)2.35587333
63Oral leukoplakia (HP:0002745)2.34676153
64Lipid accumulation in hepatocytes (HP:0006561)2.34169986
65Increased IgM level (HP:0003496)2.31426768
66Thrombocytosis (HP:0001894)2.29943410
67Abnormal gallbladder physiology (HP:0012438)2.29163827
68Cholecystitis (HP:0001082)2.29163827
69Pustule (HP:0200039)2.28685095
70IgM deficiency (HP:0002850)2.28435681
71Abnormality of the gallbladder (HP:0005264)2.28140996
72Decreased electroretinogram (ERG) amplitude (HP:0000654)2.23766968
73Recurrent fungal infections (HP:0002841)2.23625198
74Recurrent bacterial skin infections (HP:0005406)2.21615385
75Type I transferrin isoform profile (HP:0003642)2.21367682
76Reduced antithrombin III activity (HP:0001976)2.21139906
77Progressive macrocephaly (HP:0004481)2.20191508
783-Methylglutaconic aciduria (HP:0003535)2.18556147
79Osteomalacia (HP:0002749)2.16982916
80Panhypogammaglobulinemia (HP:0003139)2.16182566
81Breast hypoplasia (HP:0003187)2.14358211
82Dysostosis multiplex (HP:0000943)2.11232917
83Myelodysplasia (HP:0002863)2.11050330
84Hepatosplenomegaly (HP:0001433)2.10677620
85Abnormal platelet volume (HP:0011876)2.10485522
86Autoimmune hemolytic anemia (HP:0001890)2.10156713
87Albinism (HP:0001022)2.09256241
88Mediastinal lymphadenopathy (HP:0100721)2.07658382
89Attenuation of retinal blood vessels (HP:0007843)2.06483160
90Increased hepatocellular lipid droplets (HP:0006565)2.05488442
91Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.04040367
92Chronic otitis media (HP:0000389)2.02880631
93Systemic lupus erythematosus (HP:0002725)2.02726072
94Hyponatremia (HP:0002902)2.02712565
95Hepatocellular necrosis (HP:0001404)2.02281904
96Abnormal spermatogenesis (HP:0008669)2.02066359
97Abnormality of the heme biosynthetic pathway (HP:0010472)13.5961960
98Recurrent viral infections (HP:0004429)1.99502154
99Lactic acidosis (HP:0003128)1.98532471
100Increased mean platelet volume (HP:0011877)1.97720696
101Dicarboxylic aciduria (HP:0003215)1.96739631
102Abnormality of dicarboxylic acid metabolism (HP:0010995)1.96739631
103Microretrognathia (HP:0000308)1.96143483
104Abnormal delayed hypersensitivity skin test (HP:0002963)1.95181840
105Pancytopenia (HP:0001876)1.94943424
106Abnormality of the prostate (HP:0008775)1.93265424
107Abnormality of dental color (HP:0011073)1.92961224
108Delusions (HP:0000746)1.92897342
109Increased serum lactate (HP:0002151)1.92455603
110Muscle fiber atrophy (HP:0100295)1.92326484
111Multiple enchondromatosis (HP:0005701)1.91731573
112Encephalitis (HP:0002383)1.90790573
113Type 2 muscle fiber atrophy (HP:0003554)1.90730694
114Hepatic necrosis (HP:0002605)1.89992963
115Aplasia/Hypoplasia of the sacrum (HP:0008517)1.89917187
116Mutism (HP:0002300)1.89745693
117Seborrheic dermatitis (HP:0001051)1.88798468
118Loss of speech (HP:0002371)1.87446260
119Respiratory failure (HP:0002878)1.86000190
120Cerebral hypomyelination (HP:0006808)1.85937548
121Keratoconjunctivitis (HP:0001096)1.85611713
122Episodic fever (HP:0001954)1.85041168
123Granulocytopenia (HP:0001913)1.84075047
124Anorexia (HP:0002039)1.83861084
125Cerebral palsy (HP:0100021)1.83826144
126Abnormality of T cell physiology (HP:0011840)1.82561622
127Progressive microcephaly (HP:0000253)1.80306340
128Basal cell carcinoma (HP:0002671)1.79928530
129Increased intramyocellular lipid droplets (HP:0012240)1.77384442
130Leukocytosis (HP:0001974)1.76466420
131Poor head control (HP:0002421)1.75834955
132Menorrhagia (HP:0000132)1.74117423
133Hypoplasia of the pons (HP:0012110)1.74063375
134Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.73619982
135Hepatocellular carcinoma (HP:0001402)1.72720086
136Urticaria (HP:0001025)1.71587702
137Nonimmune hydrops fetalis (HP:0001790)1.70991650
138Carpal bone hypoplasia (HP:0001498)1.68222041
139Azoospermia (HP:0000027)1.66470184
140Abnormality of sodium homeostasis (HP:0010931)1.66214216
141Chromsome breakage (HP:0040012)1.65908813
142Abnormality of chromosome stability (HP:0003220)1.64301915
143Microvesicular hepatic steatosis (HP:0001414)1.62642423
144Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.62174834
145Abnormal protein N-linked glycosylation (HP:0012347)1.62174834
146Abnormal protein glycosylation (HP:0012346)1.62174834
147Abnormal glycosylation (HP:0012345)1.62174834
148Bone marrow hypocellularity (HP:0005528)1.61726720
149Abnormality of the pons (HP:0007361)1.60317715
150Mitochondrial inheritance (HP:0001427)1.59258460
151Small intestinal stenosis (HP:0012848)1.57787857
152Duodenal stenosis (HP:0100867)1.57787857
153Exertional dyspnea (HP:0002875)1.56698320
154Rough bone trabeculation (HP:0100670)1.56003830
155Hypopigmented skin patches (HP:0001053)1.54830097
156Hypoplasia of the capital femoral epiphysis (HP:0003090)1.54388665
157Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.54340355
158Increased muscle lipid content (HP:0009058)1.54312225
159Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.53388430
16011 pairs of ribs (HP:0000878)1.52723595
161Progressive muscle weakness (HP:0003323)1.52348757
162Patellar aplasia (HP:0006443)1.52119036

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK14.69120771
2NME23.71755192
3WEE13.52969828
4CDC73.45749322
5BUB13.08284214
6STK162.65757659
7TLK12.61268171
8VRK12.55417774
9IRAK32.52803127
10MAP4K22.47910175
11ADRBK22.47302867
12TXK2.41780519
13DYRK32.36099254
14NEK22.32491300
15BRSK12.32238095
16BRSK22.26326930
17RIPK42.11876708
18ACVR1B2.00862539
19NUAK11.96541672
20MAP3K141.93465131
21CCNB11.91668691
22STK41.83920565
23GRK71.82405933
24SCYL21.79751228
25TESK21.78896096
26VRK21.71697860
27NEK11.69727427
28CDK191.64122390
29MUSK1.62519652
30BMPR21.55095785
31PIM21.54982430
32MAP2K31.49099353
33MAP4K11.48947962
34MAP3K111.40655235
35PIM11.40378133
36AURKB1.34890682
37STK101.33451240
38PLK11.32853089
39ZAK1.29252462
40MAPKAPK51.27882929
41TSSK61.23694729
42CDK71.23500988
43FES1.23077610
44SRPK11.22444429
45IRAK41.22058050
46ATR1.21550260
47EIF2AK31.15498094
48EEF2K1.14953417
49FRK1.11295854
50MAP3K31.10462994
51CDK81.10459603
52KDR1.10357089
53AURKA1.09375321
54CDK41.05824540
55KIT1.04372330
56RPS6KB21.04144788
57TNK21.03057905
58MAP3K81.01205741
59TTK1.00712453
60CHUK1.00088346
61MAPK110.98463031
62ERN10.96316482
63MKNK10.94137550
64SYK0.92682040
65CHEK20.91252716
66MAP3K60.91212857
67MST40.90016139
68PDK20.88901257
69TGFBR10.88428415
70IRAK10.88049113
71LRRK20.87069466
72IKBKB0.83162612
73RPS6KA50.81788463
74MAP3K100.81388597
75LCK0.80473357
76INSRR0.79778899
77DAPK10.78751075
78TBK10.77389661
79MAP2K60.77204422
80ABL20.74519991
81TNIK0.74030818
82ITK0.73353126
83TYK20.72969566
84BMX0.72786611
85TEC0.72371768
86JAK20.71623851
87MAP3K50.71609783
88LYN0.71390685
89ZAP700.70621546
90FLT30.70539102
91MKNK20.70076867
92PRKCQ0.69862996
93NME10.69481717
94TAOK30.69473676
95DAPK20.69307945
96GRK60.68910474
97BCKDK0.68540875
98CHEK10.68345764
99BTK0.67178502
100JAK30.66687379
101HCK0.66156583
102CSF1R0.65453318
103TAOK10.64166811
104EIF2AK20.63946938
105PLK40.60920561
106MAP2K20.60770430
107RPS6KA40.59526398
108BLK0.58841870
109PKN10.57830853
110PLK30.57152892
111MAP3K10.56516042
112ATM0.55310409
113CSNK2A10.54463648
114TGFBR20.53888959
115HIPK20.53386722
116CAMKK20.51196166
117IKBKE0.50468738
118CSNK2A20.50221091
119MATK0.49334086
120PASK0.49014835
121MAPK30.47616907
122DYRK20.47390499
123CSK0.47274696
124BMPR1B0.44316511
125MARK30.44158984
126PKN20.43821318
127CLK10.43791934
128MAPK130.42550086
129CDK20.42538114
130GRK10.42198874
131MAPKAPK30.41090467
132ADRBK10.39603301
133WNK40.38508749
134TAOK20.38249523
135PAK10.37389879
136CSNK1G30.36513472
137RAF10.35737198
138TIE10.35022800
139CDK60.34725373
140ILK0.34500649
141FGR0.33089180
142RPS6KA60.33048274
143BRAF0.32439502
144TRPM70.32042476
145MAPK40.30292985
146ABL10.29913426
147CDK10.29527785
148STK240.28737477

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.44041579
2Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008605.21706333
3Ribosome_Homo sapiens_hsa030104.24346626
4Mismatch repair_Homo sapiens_hsa034303.53251794
5Allograft rejection_Homo sapiens_hsa053302.88398976
6Base excision repair_Homo sapiens_hsa034102.83417769
7Homologous recombination_Homo sapiens_hsa034402.83048618
8Proteasome_Homo sapiens_hsa030502.73399693
9Nucleotide excision repair_Homo sapiens_hsa034202.63070032
10RNA polymerase_Homo sapiens_hsa030202.58582490
11Pyrimidine metabolism_Homo sapiens_hsa002402.55922829
12Graft-versus-host disease_Homo sapiens_hsa053322.48145815
13Rheumatoid arthritis_Homo sapiens_hsa053232.48130389
14Systemic lupus erythematosus_Homo sapiens_hsa053222.44692684
15Cell cycle_Homo sapiens_hsa041102.43804995
16Vitamin B6 metabolism_Homo sapiens_hsa007502.40633264
17Spliceosome_Homo sapiens_hsa030402.39718968
18Autoimmune thyroid disease_Homo sapiens_hsa053202.27528643
19Type I diabetes mellitus_Homo sapiens_hsa049402.23604365
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.19017586
21Staphylococcus aureus infection_Homo sapiens_hsa051502.13857763
22NOD-like receptor signaling pathway_Homo sapiens_hsa046212.10712282
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.08741600
24One carbon pool by folate_Homo sapiens_hsa006702.02166941
25RNA transport_Homo sapiens_hsa030132.00617407
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.92197288
27Sulfur relay system_Homo sapiens_hsa041221.84257795
28Fanconi anemia pathway_Homo sapiens_hsa034601.73510083
29Toll-like receptor signaling pathway_Homo sapiens_hsa046201.68329841
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.67108624
31Lysosome_Homo sapiens_hsa041421.56256917
32African trypanosomiasis_Homo sapiens_hsa051431.54977733
33Non-homologous end-joining_Homo sapiens_hsa034501.52751783
34Glycosaminoglycan degradation_Homo sapiens_hsa005311.46574279
35p53 signaling pathway_Homo sapiens_hsa041151.43352672
36Folate biosynthesis_Homo sapiens_hsa007901.42693286
37Osteoclast differentiation_Homo sapiens_hsa043801.39497719
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.38437608
39Hematopoietic cell lineage_Homo sapiens_hsa046401.38118695
40Purine metabolism_Homo sapiens_hsa002301.35251029
41TNF signaling pathway_Homo sapiens_hsa046681.33321705
42Collecting duct acid secretion_Homo sapiens_hsa049661.31773729
43Tuberculosis_Homo sapiens_hsa051521.31605329
44RNA degradation_Homo sapiens_hsa030181.30903711
45Basal transcription factors_Homo sapiens_hsa030221.19137197
46Pertussis_Homo sapiens_hsa051331.17926702
47Alcoholism_Homo sapiens_hsa050341.11792219
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.10768372
49Pentose phosphate pathway_Homo sapiens_hsa000301.06761489
50Parkinsons disease_Homo sapiens_hsa050121.04519543
51Herpes simplex infection_Homo sapiens_hsa051681.03410022
52Selenocompound metabolism_Homo sapiens_hsa004500.98488360
53Toxoplasmosis_Homo sapiens_hsa051450.95761654
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93544113
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.92730048
56SNARE interactions in vesicular transport_Homo sapiens_hsa041300.90136812
57Viral carcinogenesis_Homo sapiens_hsa052030.87319278
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.86101897
59Nitrogen metabolism_Homo sapiens_hsa009100.83935284
60Salmonella infection_Homo sapiens_hsa051320.82926595
61ABC transporters_Homo sapiens_hsa020100.81700203
62Epstein-Barr virus infection_Homo sapiens_hsa051690.78202276
63Huntingtons disease_Homo sapiens_hsa050160.77629952
64Viral myocarditis_Homo sapiens_hsa054160.77334047
65Protein export_Homo sapiens_hsa030600.77266997
66Peroxisome_Homo sapiens_hsa041460.76081784
67mRNA surveillance pathway_Homo sapiens_hsa030150.75546740
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.71731193
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71701279
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71700059
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69194213
72Oxidative phosphorylation_Homo sapiens_hsa001900.68336330
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67053007
74Malaria_Homo sapiens_hsa051440.66798950
75Glutathione metabolism_Homo sapiens_hsa004800.66675616
76Apoptosis_Homo sapiens_hsa042100.66585534
77Sulfur metabolism_Homo sapiens_hsa009200.66444763
78Antigen processing and presentation_Homo sapiens_hsa046120.65707302
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.65238695
80Tryptophan metabolism_Homo sapiens_hsa003800.64210097
81Fatty acid elongation_Homo sapiens_hsa000620.63276833
82Phagosome_Homo sapiens_hsa041450.62103366
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60622516
84N-Glycan biosynthesis_Homo sapiens_hsa005100.60583283
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59850163
86Measles_Homo sapiens_hsa051620.57907179
87Arachidonic acid metabolism_Homo sapiens_hsa005900.56659883
88Phototransduction_Homo sapiens_hsa047440.54646814
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54557084
90Biosynthesis of amino acids_Homo sapiens_hsa012300.52078274
91Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52057893
92Legionellosis_Homo sapiens_hsa051340.52019235
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51936092
94Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.51706051
95Small cell lung cancer_Homo sapiens_hsa052220.49853246
96Oocyte meiosis_Homo sapiens_hsa041140.49590328
97Cyanoamino acid metabolism_Homo sapiens_hsa004600.46115282
98Metabolic pathways_Homo sapiens_hsa011000.46009795
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.45344581
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44628298
101Hepatitis C_Homo sapiens_hsa051600.43929571
102RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.43166510
103Hepatitis B_Homo sapiens_hsa051610.41205232
104Platelet activation_Homo sapiens_hsa046110.40689218
105Chronic myeloid leukemia_Homo sapiens_hsa052200.40290844
106Ether lipid metabolism_Homo sapiens_hsa005650.39250886
107Sphingolipid metabolism_Homo sapiens_hsa006000.39171911
108Carbon metabolism_Homo sapiens_hsa012000.38566051
109Primary immunodeficiency_Homo sapiens_hsa053400.38372306
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.37869158
111Regulation of autophagy_Homo sapiens_hsa041400.37799550
112Maturity onset diabetes of the young_Homo sapiens_hsa049500.37473649
113Bladder cancer_Homo sapiens_hsa052190.36521094
114Alzheimers disease_Homo sapiens_hsa050100.36220051
115Linoleic acid metabolism_Homo sapiens_hsa005910.35551784
116Galactose metabolism_Homo sapiens_hsa000520.35339909
117Non-small cell lung cancer_Homo sapiens_hsa052230.33801411
118Other glycan degradation_Homo sapiens_hsa005110.29458885
119Influenza A_Homo sapiens_hsa051640.29376522
120HTLV-I infection_Homo sapiens_hsa051660.28934374
121Acute myeloid leukemia_Homo sapiens_hsa052210.28921475
122Leishmaniasis_Homo sapiens_hsa051400.27104253
123Thyroid cancer_Homo sapiens_hsa052160.25412294
124Fructose and mannose metabolism_Homo sapiens_hsa000510.25273983
125Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.23069577
126Caffeine metabolism_Homo sapiens_hsa002320.23059968
127NF-kappa B signaling pathway_Homo sapiens_hsa040640.22988581
128Jak-STAT signaling pathway_Homo sapiens_hsa046300.19487679
129Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.19435007
130Asthma_Homo sapiens_hsa053100.18307386
131Pyruvate metabolism_Homo sapiens_hsa006200.17697617
132Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.16156287
133Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.15977947
134B cell receptor signaling pathway_Homo sapiens_hsa046620.15460229
135Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.14941445
136Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.13944092
137Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.13447370
138Shigellosis_Homo sapiens_hsa051310.13106857
139Intestinal immune network for IgA production_Homo sapiens_hsa046720.08577561

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