ICE1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)8.04569927
2pore complex assembly (GO:0046931)6.61941968
3mitotic chromosome condensation (GO:0007076)5.08692791
4DNA unwinding involved in DNA replication (GO:0006268)4.84413820
5locomotory exploration behavior (GO:0035641)4.42337119
6regulation of short-term neuronal synaptic plasticity (GO:0048172)4.31059766
7synaptic vesicle maturation (GO:0016188)4.16415423
8negative regulation of DNA repair (GO:0045738)4.12865477
9layer formation in cerebral cortex (GO:0021819)4.03115399
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.99257728
11DNA duplex unwinding (GO:0032508)3.97490548
12sister chromatid segregation (GO:0000819)3.94686725
13mitotic nuclear envelope disassembly (GO:0007077)3.94486284
14establishment of nucleus localization (GO:0040023)3.90959439
15membrane disassembly (GO:0030397)3.86748722
16nuclear envelope disassembly (GO:0051081)3.86748722
17protein localization to chromosome, centromeric region (GO:0071459)3.85681478
18DNA geometric change (GO:0032392)3.80276849
19pre-miRNA processing (GO:0031054)3.74990905
20protein localization to kinetochore (GO:0034501)3.74003373
21mitotic sister chromatid segregation (GO:0000070)3.70593410
22regulation of clathrin-mediated endocytosis (GO:2000369)3.70137674
23regulation of centriole replication (GO:0046599)3.68122686
24positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.64797641
25cytoplasmic mRNA processing body assembly (GO:0033962)3.61251511
26synaptic vesicle docking involved in exocytosis (GO:0016081)3.57180205
27cellular protein complex localization (GO:0034629)3.55413358
28regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.46851041
29regulation of histone H3-K9 methylation (GO:0051570)3.45699100
30regulation of translational fidelity (GO:0006450)3.44771246
31protein export from nucleus (GO:0006611)3.39906836
32DNA topological change (GO:0006265)3.35122816
33regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.33512786
34heterochromatin organization (GO:0070828)3.33064208
35protein complex localization (GO:0031503)3.31760327
36sister chromatid cohesion (GO:0007062)3.30776392
37vocalization behavior (GO:0071625)3.24767512
38DNA conformation change (GO:0071103)3.24248063
39regulation of mitotic spindle organization (GO:0060236)3.22740059
40paraxial mesoderm development (GO:0048339)3.22422603
41positive regulation of chromosome segregation (GO:0051984)3.22049246
42ribosome assembly (GO:0042255)3.21260717
43mRNA stabilization (GO:0048255)3.20261438
44RNA stabilization (GO:0043489)3.20261438
45sodium ion export (GO:0071436)3.19731769
46regulation of glutamate receptor signaling pathway (GO:1900449)3.17547324
47dendritic spine morphogenesis (GO:0060997)3.13905328
48mitotic metaphase plate congression (GO:0007080)3.13716849
49embryonic process involved in female pregnancy (GO:0060136)3.13488564
50cerebellar Purkinje cell differentiation (GO:0021702)3.13329856
51nuclear envelope organization (GO:0006998)3.13106455
52DNA replication initiation (GO:0006270)3.11350025
53spliceosomal tri-snRNP complex assembly (GO:0000244)3.08826820
54regulation of histone H3-K27 methylation (GO:0061085)3.08636725
55regulation of ARF protein signal transduction (GO:0032012)3.07852551
56DNA synthesis involved in DNA repair (GO:0000731)3.07390825
57cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.06066364
58synaptic vesicle exocytosis (GO:0016079)3.04943558
59monoubiquitinated protein deubiquitination (GO:0035520)3.04806988
60exploration behavior (GO:0035640)3.04689066
61non-recombinational repair (GO:0000726)3.03354196
62double-strand break repair via nonhomologous end joining (GO:0006303)3.03354196
63dendrite morphogenesis (GO:0048813)3.02267562
64regulation of centrosome duplication (GO:0010824)3.01951564
65regulation of synapse structural plasticity (GO:0051823)3.01118623
66regulation of centrosome cycle (GO:0046605)2.99924094
67glutamate secretion (GO:0014047)2.99215721
68ionotropic glutamate receptor signaling pathway (GO:0035235)2.98858070
69nucleus organization (GO:0006997)2.98405385
70regulation of spindle organization (GO:0090224)2.98158138
71cell migration in hindbrain (GO:0021535)2.97533220
72positive regulation of cell cycle checkpoint (GO:1901978)2.96857272
73DNA strand elongation involved in DNA replication (GO:0006271)2.96048330
74dosage compensation (GO:0007549)2.95239410
75cell communication by electrical coupling (GO:0010644)2.92803491
76chromosome condensation (GO:0030261)2.92753458
77nucleus localization (GO:0051647)2.89689459
78regulation of synaptic vesicle exocytosis (GO:2000300)2.87845872
79DNA strand elongation (GO:0022616)2.86776652
80positive regulation of synapse maturation (GO:0090129)2.86554699
81mRNA transport (GO:0051028)2.85851049
82regulation of long-term neuronal synaptic plasticity (GO:0048169)2.85559624
83neuromuscular process controlling balance (GO:0050885)2.84238234
84proline transport (GO:0015824)2.83868069
85regulation of DNA endoreduplication (GO:0032875)2.83451413
86activation of protein kinase A activity (GO:0034199)2.78997532
87protein localization to synapse (GO:0035418)2.78916610
88positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.77133349
89positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.77133349
90positive regulation of mitotic sister chromatid separation (GO:1901970)2.77133349
91stress granule assembly (GO:0034063)2.76944167
92cytoskeletal anchoring at plasma membrane (GO:0007016)2.75791371
93negative regulation of histone methylation (GO:0031061)2.74989327
94regulation of neuronal synaptic plasticity (GO:0048168)2.74080489
95metaphase plate congression (GO:0051310)2.73741733
96vesicle transport along microtubule (GO:0047496)2.73221452
97plasma membrane repair (GO:0001778)2.72663317
98regulation of chromosome segregation (GO:0051983)2.72535036
99regulation of dendritic spine morphogenesis (GO:0061001)2.72034345
100regulation of DNA damage checkpoint (GO:2000001)2.71752840
101morphogenesis of an epithelial sheet (GO:0002011)2.70355357
102DNA packaging (GO:0006323)2.68247693
103regulation of histone methylation (GO:0031060)2.67957925
104axonal fasciculation (GO:0007413)2.67090858
105cellular potassium ion homeostasis (GO:0030007)2.66290508
106nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.66232053
107histone H3-K4 trimethylation (GO:0080182)2.66174483
108mitotic cytokinesis (GO:0000281)2.64855142
109regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.64097553
110glutamate receptor signaling pathway (GO:0007215)2.62559438
111establishment of chromosome localization (GO:0051303)2.60271001
112hippo signaling (GO:0035329)2.60263367
113neurotransmitter secretion (GO:0007269)2.60060867
114histone H3-K4 methylation (GO:0051568)2.60018357
115peptidyl-threonine phosphorylation (GO:0018107)2.58222925
116positive regulation of SMAD protein import into nucleus (GO:0060391)2.57450966
117synaptic transmission, glutamatergic (GO:0035249)2.57069247
118membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.56820786
119negative regulation of histone modification (GO:0031057)2.56183240
120protein localization to chromosome (GO:0034502)2.55819918
121regulation of synaptic vesicle transport (GO:1902803)2.55462157
122long-term memory (GO:0007616)2.55138455
123regulation of mitotic metaphase/anaphase transition (GO:0030071)2.55114893
124regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.55114893
125prepulse inhibition (GO:0060134)2.54031782
126regulation of sister chromatid segregation (GO:0033045)2.53053259
127regulation of mitotic sister chromatid separation (GO:0010965)2.53053259
128regulation of mitotic sister chromatid segregation (GO:0033047)2.53053259
129RNA transport (GO:0050658)2.52793871
130establishment of RNA localization (GO:0051236)2.52793871
131nucleic acid transport (GO:0050657)2.52793871
132protein localization to microtubule (GO:0035372)2.52703187
133negative regulation of chromosome segregation (GO:0051985)2.51720333
134regulation of chromatin binding (GO:0035561)2.51634778
135spindle checkpoint (GO:0031577)2.51555532
136organelle transport along microtubule (GO:0072384)2.51388221
137neuron recognition (GO:0008038)2.50440857
138regulation of histone H3-K4 methylation (GO:0051569)2.49773648
139formation of translation preinitiation complex (GO:0001731)2.49337994
140chromatin assembly (GO:0031497)2.49195865
141DNA replication checkpoint (GO:0000076)2.48781566
142regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.48444975
143V(D)J recombination (GO:0033151)2.48381023
144NLS-bearing protein import into nucleus (GO:0006607)2.47898813
145glucocorticoid receptor signaling pathway (GO:0042921)2.46323866
146clathrin coat assembly (GO:0048268)2.45530205
147corticosteroid receptor signaling pathway (GO:0031958)2.44329304
148central nervous system projection neuron axonogenesis (GO:0021952)2.42982325
149synaptic vesicle endocytosis (GO:0048488)2.42971782
150peptidyl-lysine dimethylation (GO:0018027)2.42542602
151histone lysine methylation (GO:0034968)2.41200715
152G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.40662790
153gamma-aminobutyric acid transport (GO:0015812)2.39567887
154mitotic sister chromatid cohesion (GO:0007064)2.37507916
155nerve growth factor signaling pathway (GO:0038180)2.37197453
156peptidyl-threonine modification (GO:0018210)2.35852260
157innervation (GO:0060384)2.35770698
158histone H3-K36 demethylation (GO:0070544)2.32425108
159histone H2A monoubiquitination (GO:0035518)2.32279817
160neuronal action potential propagation (GO:0019227)2.30518677
161regulation of excitatory postsynaptic membrane potential (GO:0060079)2.29524347
162positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.29433004
163regulation of NFAT protein import into nucleus (GO:0051532)2.28958214
164insulin-like growth factor receptor signaling pathway (GO:0048009)2.27746912
165positive regulation of dendritic spine morphogenesis (GO:0061003)2.26708660
166membrane depolarization during action potential (GO:0086010)2.26231691
167neuron cell-cell adhesion (GO:0007158)2.26167754
168negative regulation of hormone metabolic process (GO:0032351)2.25444147
169negative regulation of hormone biosynthetic process (GO:0032353)2.25444147
170regulation of RNA export from nucleus (GO:0046831)2.24981669
171peptidyl-lysine trimethylation (GO:0018023)2.24431399
172regulation of postsynaptic membrane potential (GO:0060078)2.23904000
173neuron-neuron synaptic transmission (GO:0007270)2.23740127
174regulation of ARF GTPase activity (GO:0032312)2.23197518
175cardiac myofibril assembly (GO:0055003)2.23086685
176nuclear pore complex assembly (GO:0051292)2.21628566
177regulation of Rap GTPase activity (GO:0032317)2.21042375
178positive regulation of fibroblast migration (GO:0010763)2.20785579
179regulation of nucleobase-containing compound transport (GO:0032239)2.18355335
180regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.18155002
181negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.17500725
182regulation of sister chromatid cohesion (GO:0007063)2.17214197
183G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.16348053
184regulation of synaptic plasticity (GO:0048167)2.15857665
185positive regulation of Rap GTPase activity (GO:0032854)2.15737901
186dendritic spine organization (GO:0097061)2.15710822

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.38146276
2E2F4_17652178_ChIP-ChIP_JURKAT_Human3.82673980
3AR_21909140_ChIP-Seq_LNCAP_Human2.92134913
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.78238890
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.77243270
6EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.76787509
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.65550189
8E2F1_21310950_ChIP-Seq_MCF-7_Human2.55416245
9RARB_27405468_Chip-Seq_BRAIN_Mouse2.41434940
10TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.29417956
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.27338970
12DROSHA_22980978_ChIP-Seq_HELA_Human2.22823138
13SMAD_19615063_ChIP-ChIP_OVARY_Human2.11057521
14PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.10846746
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.09767110
16RBPJ_22232070_ChIP-Seq_NCS_Mouse2.04142473
17E2F7_22180533_ChIP-Seq_HELA_Human10.6872712
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.98757573
19WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.97754657
20DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.94516346
21YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.93399369
22ZFP281_27345836_Chip-Seq_ESCs_Mouse1.88503644
23JARID2_20064375_ChIP-Seq_MESCs_Mouse1.87978035
24MYC_19079543_ChIP-ChIP_MESCs_Mouse1.87763755
25SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.86953305
26KDM2B_26808549_Chip-Seq_K562_Human1.86542664
27MYCN_18555785_ChIP-Seq_MESCs_Mouse1.85081145
28ZNF263_19887448_ChIP-Seq_K562_Human1.84655243
29SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.83755085
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.81004440
31GBX2_23144817_ChIP-Seq_PC3_Human1.79975991
32EZH2_18974828_ChIP-Seq_MESCs_Mouse1.79531244
33RNF2_18974828_ChIP-Seq_MESCs_Mouse1.79531244
34CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.79412891
35SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.77331199
36MYC_19030024_ChIP-ChIP_MESCs_Mouse1.74107492
37FOXM1_23109430_ChIP-Seq_U2OS_Human1.73107037
38ZFX_18555785_ChIP-Seq_MESCs_Mouse1.72977466
39ZFP281_18757296_ChIP-ChIP_E14_Mouse1.72002112
40KDM2B_26808549_Chip-Seq_SUP-B15_Human1.69611607
41CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.69405331
42BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.69324891
43KDM2B_26808549_Chip-Seq_DND41_Human1.68143631
44SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.67698372
45REST_21632747_ChIP-Seq_MESCs_Mouse1.66255895
46AR_21572438_ChIP-Seq_LNCaP_Human1.61596398
47TP53_16413492_ChIP-PET_HCT116_Human1.59660193
48RNF2_27304074_Chip-Seq_ESCs_Mouse1.57930754
49SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.57843995
50KDM2B_26808549_Chip-Seq_JURKAT_Human1.57568092
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.57308735
52MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.56051634
53NELFA_20434984_ChIP-Seq_ESCs_Mouse1.52581585
54MTF2_20144788_ChIP-Seq_MESCs_Mouse1.50916499
55CLOCK_20551151_ChIP-Seq_293T_Human1.49573277
56NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.49454229
57STAT6_21828071_ChIP-Seq_BEAS2B_Human1.48323559
58HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.47894495
59AR_19668381_ChIP-Seq_PC3_Human1.47310170
60WT1_25993318_ChIP-Seq_PODOCYTE_Human1.46212429
61CHD1_26751641_Chip-Seq_LNCaP_Human1.44830336
62CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.44505285
63EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.42726220
64EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.41816560
65ZNF217_24962896_ChIP-Seq_MCF-7_Human1.41811091
66KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.41484346
67KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.41246437
68FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.41114444
69WT1_19549856_ChIP-ChIP_CCG9911_Human1.40193494
70TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.37262201
71KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.37071698
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.37067486
73EZH2_27304074_Chip-Seq_ESCs_Mouse1.36210122
74PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36021426
75EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.35972704
76SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.35775603
77ESR1_20079471_ChIP-ChIP_T-47D_Human1.35018687
78TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33795504
79CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.32296241
80JARID2_20075857_ChIP-Seq_MESCs_Mouse1.31618629
81KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.31028238
82EGR1_19374776_ChIP-ChIP_THP-1_Human1.30877807
83SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.30521109
84MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.29111624
85SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.28366778
86MYC_22102868_ChIP-Seq_BL_Human1.27904067
87ISL1_27105846_Chip-Seq_CPCs_Mouse1.27762290
88SOX2_21211035_ChIP-Seq_LN229_Gbm1.27692469
89GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27541453
90REST_18959480_ChIP-ChIP_MESCs_Mouse1.27089174
91YAP1_20516196_ChIP-Seq_MESCs_Mouse1.26825931
92KLF4_18555785_ChIP-Seq_MESCs_Mouse1.26402867
93TFEB_21752829_ChIP-Seq_HELA_Human1.24892276
94MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.24234323
95STAT3_23295773_ChIP-Seq_U87_Human1.24008281
96GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.23935204
97HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.23462730
98TCF7_22412390_ChIP-Seq_EML_Mouse1.22410391
99SMAD4_21799915_ChIP-Seq_A2780_Human1.22149233
100DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.22106452
101AHR_22903824_ChIP-Seq_MCF-7_Human1.20744261
102SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.19950226
103CTNNB1_20460455_ChIP-Seq_HCT116_Human1.19831449
104PADI4_21655091_ChIP-ChIP_MCF-7_Human1.19582239
105EZH2_27294783_Chip-Seq_ESCs_Mouse1.18493709
106IKZF1_21737484_ChIP-ChIP_HCT116_Human1.17585769
107RING1B_27294783_Chip-Seq_NPCs_Mouse1.17148498
108CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15267389
109ARNT_22903824_ChIP-Seq_MCF-7_Human1.15065842
110NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.14575845
111ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.14518191
112SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.13013380
113SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.12668971
114SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.12668971
115ZNF274_21170338_ChIP-Seq_K562_Hela1.11671990
116SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.11396147
117ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.09716278
118P300_27058665_Chip-Seq_ZR-75-30cells_Human1.09302953
119FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.08942220
120SUZ12_27294783_Chip-Seq_ESCs_Mouse1.08108363
121POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07614335
122TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07614335
123AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07447163
124FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.07401595
125CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07270102
126KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06528049
127EP300_21415370_ChIP-Seq_HL-1_Mouse1.06454102
128GATA1_22025678_ChIP-Seq_K562_Human1.06200520
129TP63_19390658_ChIP-ChIP_HaCaT_Human1.04402940
130RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.03823085
131SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03749230
132RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.03352047
133CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03253698
134ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.03082559
135SALL4_18804426_ChIP-ChIP_XEN_Mouse1.03032805
136TBX3_20139965_ChIP-Seq_ESCs_Mouse1.02459224
137VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.02451285
138TCF4_23295773_ChIP-Seq_U87_Human1.02178360
139PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.01788072
140PKCTHETA_26484144_Chip-Seq_BREAST_Human1.01772000
141RING1B_27294783_Chip-Seq_ESCs_Mouse1.01217999
142TBX3_20139965_ChIP-Seq_MESCs_Mouse1.00993943
143MYB_21317192_ChIP-Seq_ERMYB_Mouse0.98432862
144KDM5A_27292631_Chip-Seq_BREAST_Human0.98201343
145SMAD3_21741376_ChIP-Seq_HESCs_Human0.97871281
146E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97850038
147EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.97575157
148TCF4_18268006_ChIP-ChIP_LS174T_Human0.97100378
149NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.95778447
150BRD4_25478319_ChIP-Seq_HGPS_Human0.94774378
151P53_22127205_ChIP-Seq_FIBROBLAST_Human0.94700848
152NANOG_21062744_ChIP-ChIP_HESCs_Human0.94291861
153SOX17_20123909_ChIP-Seq_XEN_Mouse0.94108921
154NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94041911
155ERG_21242973_ChIP-ChIP_JURKAT_Human0.93775810
156ESR1_15608294_ChIP-ChIP_MCF-7_Human0.91609052
157FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.91590265
158MYC_18358816_ChIP-ChIP_MESCs_Mouse0.91292187
159XRN2_22483619_ChIP-Seq_HELA_Human0.91204561
160ELK1_19687146_ChIP-ChIP_HELA_Human0.89422520
161TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88139572
162ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.87632755
163TTF2_22483619_ChIP-Seq_HELA_Human0.87444247
164DCP1A_22483619_ChIP-Seq_HELA_Human0.86726600
165SOX9_24532713_ChIP-Seq_HFSC_Mouse0.84849712
166UBF1/2_26484160_Chip-Seq_HMECs_Human0.82452881
167KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.81515321
168KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.81515321
169KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.81515321
170CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.80734766
171TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.80195890
172ERG_20887958_ChIP-Seq_HPC-7_Mouse0.80129920
173STAT3_1855785_ChIP-Seq_MESCs_Mouse0.79327715
174DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.77412900
175STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.73774942
176BRD4_27068464_Chip-Seq_AML-cells_Mouse0.73696522

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.34120436
2MP0004859_abnormal_synaptic_plasticity5.27896375
3MP0000569_abnormal_digit_pigmentation3.37006358
4MP0010094_abnormal_chromosome_stability3.25428326
5MP0003111_abnormal_nucleus_morphology3.04445845
6MP0002009_preneoplasia2.97122494
7MP0003635_abnormal_synaptic_transmissio2.89862038
8MP0003787_abnormal_imprinting2.86466685
9MP0003693_abnormal_embryo_hatching2.85521157
10MP0004957_abnormal_blastocyst_morpholog2.81296309
11MP0003077_abnormal_cell_cycle2.80045733
12MP0004270_analgesia2.66011215
13MP0002396_abnormal_hematopoietic_system2.62790694
14MP0002877_abnormal_melanocyte_morpholog2.56511813
15MP0000751_myopathy2.32789980
16MP0005423_abnormal_somatic_nervous2.30651079
17MP0002063_abnormal_learning/memory/cond2.25701607
18MP0010307_abnormal_tumor_latency2.21451692
19MP0003941_abnormal_skin_development2.09809020
20MP0009046_muscle_twitch2.01758163
21MP0003880_abnormal_central_pattern1.99599665
22MP0009780_abnormal_chondrocyte_physiolo1.92635972
23MP0008007_abnormal_cellular_replicative1.92185842
24MP0003705_abnormal_hypodermis_morpholog1.91675116
25MP0004808_abnormal_hematopoietic_stem1.87633374
26MP0008932_abnormal_embryonic_tissue1.86636666
27MP0009745_abnormal_behavioral_response1.85268176
28MP0008058_abnormal_DNA_repair1.75617237
29MP0003121_genomic_imprinting1.75592342
30MP0002064_seizures1.70369106
31MP0000778_abnormal_nervous_system1.69024855
32MP0009672_abnormal_birth_weight1.66023276
33MP0004145_abnormal_muscle_electrophysio1.65131035
34MP0005076_abnormal_cell_differentiation1.64867728
35MP0004233_abnormal_muscle_weight1.60166394
36MP0002572_abnormal_emotion/affect_behav1.59909940
37MP0003566_abnormal_cell_adhesion1.58288657
38MP0002734_abnormal_mechanical_nocicepti1.56092999
39MP0001486_abnormal_startle_reflex1.54496586
40MP0003123_paternal_imprinting1.50310711
41MP0002080_prenatal_lethality1.48149400
42MP0005187_abnormal_penis_morphology1.47593602
43MP0008961_abnormal_basal_metabolism1.44917558
44MP0002184_abnormal_innervation1.42301406
45MP0004811_abnormal_neuron_physiology1.40140033
46MP0001661_extended_life_span1.39310194
47MP0001299_abnormal_eye_distance/1.37976607
48MP0004885_abnormal_endolymph1.36980330
49MP0002697_abnormal_eye_size1.36691767
50MP0005409_darkened_coat_color1.34866466
51MP0004510_myositis1.34569783
52MP0008569_lethality_at_weaning1.33527817
53MP0005623_abnormal_meninges_morphology1.33010900
54MP0003122_maternal_imprinting1.32420871
55MP0002653_abnormal_ependyma_morphology1.31995748
56MP0001915_intracranial_hemorrhage1.31027369
57MP0000733_abnormal_muscle_development1.28607435
58MP0003861_abnormal_nervous_system1.26313281
59MP0010678_abnormal_skin_adnexa1.26169982
60MP0002152_abnormal_brain_morphology1.24209036
61MP0010234_abnormal_vibrissa_follicle1.23980101
62MP0000955_abnormal_spinal_cord1.23571806
63MP0009697_abnormal_copulation1.23120380
64MP0002084_abnormal_developmental_patter1.23070336
65MP0005621_abnormal_cell_physiology1.23036573
66MP0003890_abnormal_embryonic-extraembry1.22337232
67MP0004858_abnormal_nervous_system1.20963273
68MP0002272_abnormal_nervous_system1.19220225
69MP0002909_abnormal_adrenal_gland1.17915114
70MP0001968_abnormal_touch/_nociception1.17800735
71MP0004084_abnormal_cardiac_muscle1.17041160
72MP0003950_abnormal_plasma_membrane1.15940607
73MP0004924_abnormal_behavior1.15660643
74MP0005386_behavior/neurological_phenoty1.15660643
75MP0003283_abnormal_digestive_organ1.14503579
76MP0004087_abnormal_muscle_fiber1.12916118
77MP0003385_abnormal_body_wall1.12286493
78MP0005248_abnormal_Harderian_gland1.12034792
79MP0003119_abnormal_digestive_system1.11843199
80MP0002067_abnormal_sensory_capabilities1.11722050
81MP0008877_abnormal_DNA_methylation1.10744486
82MP0002882_abnormal_neuron_morphology1.09569239
83MP0004215_abnormal_myocardial_fiber1.08911687
84MP0003453_abnormal_keratinocyte_physiol1.08888192
85MP0003646_muscle_fatigue1.08216559
86MP0003045_fibrosis1.05357713
87MP0010352_gastrointestinal_tract_polyps1.05266923
88MP0004185_abnormal_adipocyte_glucose1.05116090
89MP0000003_abnormal_adipose_tissue1.04186351
90MP0003221_abnormal_cardiomyocyte_apopto1.03417347
91MP0002557_abnormal_social/conspecific_i1.02962564
92MP0003763_abnormal_thymus_physiology1.02009178
93MP0003935_abnormal_craniofacial_develop1.01496978
94MP0003115_abnormal_respiratory_system1.00588833
95MP0002092_abnormal_eye_morphology1.00401372
96MP0002166_altered_tumor_susceptibility0.99817706
97MP0001440_abnormal_grooming_behavior0.99642034
98MP0002822_catalepsy0.97992808
99MP0003656_abnormal_erythrocyte_physiolo0.97804270
100MP0000383_abnormal_hair_follicle0.97760303
101MP0003137_abnormal_impulse_conducting0.97625645
102MP0001849_ear_inflammation0.96387816
103MP0000428_abnormal_craniofacial_morphol0.96215170
104MP0000313_abnormal_cell_death0.95733097
105MP0002066_abnormal_motor_capabilities/c0.94996274
106MP0003943_abnormal_hepatobiliary_system0.94866618
107MP0000537_abnormal_urethra_morphology0.94556701
108MP0005384_cellular_phenotype0.94157039
109MP0002085_abnormal_embryonic_tissue0.94120075
110MP0002060_abnormal_skin_morphology0.93715945
111MP0004484_altered_response_of0.93661210
112MP0000432_abnormal_head_morphology0.93163544
113MP0004085_abnormal_heartbeat0.92620825
114MP0000747_muscle_weakness0.90846531
115MP0002089_abnormal_postnatal_growth/wei0.90588685
116MP0003091_abnormal_cell_migration0.89210061
117MP0002733_abnormal_thermal_nociception0.88737053
118MP0010630_abnormal_cardiac_muscle0.88677081
119MP0001730_embryonic_growth_arrest0.87766446
120MP0003632_abnormal_nervous_system0.87313914
121MP0005380_embryogenesis_phenotype0.86887494
122MP0001672_abnormal_embryogenesis/_devel0.86887494
123MP0004272_abnormal_basement_membrane0.86755897
124MP0002925_abnormal_cardiovascular_devel0.86733299
125MP0002269_muscular_atrophy0.86408032
126MP0001970_abnormal_pain_threshold0.86179599
127MP0002006_tumorigenesis0.86003224
128MP0005666_abnormal_adipose_tissue0.85176990
129MP0003984_embryonic_growth_retardation0.84455810
130MP0002106_abnormal_muscle_physiology0.84239107
131MP0002088_abnormal_embryonic_growth/wei0.82848152
132MP0000534_abnormal_ureter_morphology0.82621578
133MP0004197_abnormal_fetal_growth/weight/0.81734213
134MP0003937_abnormal_limbs/digits/tail_de0.81663683
135MP0003755_abnormal_palate_morphology0.81306404
136MP0004130_abnormal_muscle_cell0.80902777
137MP0001286_abnormal_eye_development0.80862838
138MP0009703_decreased_birth_body0.80557431
139MP0005375_adipose_tissue_phenotype0.80402938
140MP0002735_abnormal_chemical_nociception0.80057767
141MP0001501_abnormal_sleep_pattern0.79654683
142MP0000579_abnormal_nail_morphology0.79533003
143MP0008770_decreased_survivor_rate0.78430359
144MP0005451_abnormal_body_composition0.77502867
145MP0005257_abnormal_intraocular_pressure0.77190034
146MP0001697_abnormal_embryo_size0.77167860
147MP0002086_abnormal_extraembryonic_tissu0.77045750
148MP0002796_impaired_skin_barrier0.77033851
149MP0008438_abnormal_cutaneous_collagen0.76593270
150MP0000759_abnormal_skeletal_muscle0.76193836
151MP0000377_abnormal_hair_follicle0.75606093
152MP0000350_abnormal_cell_proliferation0.75478140
153MP0003786_premature_aging0.74371369
154MP0003718_maternal_effect0.74218694
155MP0001348_abnormal_lacrimal_gland0.73427247
156MP0002019_abnormal_tumor_incidence0.70602586
157MP0002114_abnormal_axial_skeleton0.67330963
158MP0003300_gastrointestinal_ulcer0.67294636
159MP0000627_abnormal_mammary_gland0.66480436
160MP0002111_abnormal_tail_morphology0.65793287
161MP0000703_abnormal_thymus_morphology0.65390843
162MP0003567_abnormal_fetal_cardiomyocyte0.64090369
163MP0006138_congestive_heart_failure0.63650859
164MP0001340_abnormal_eyelid_morphology0.63404839

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)3.32229506
2Chromosomal breakage induced by crosslinking agents (HP:0003221)3.24826958
3Focal seizures (HP:0007359)2.97701218
4Deep philtrum (HP:0002002)2.91392167
5Genetic anticipation (HP:0003743)2.88046664
6Focal motor seizures (HP:0011153)2.82574930
7Urinary bladder sphincter dysfunction (HP:0002839)2.67393589
8Asymmetry of the thorax (HP:0001555)2.64599182
9Nephroblastoma (Wilms tumor) (HP:0002667)2.63480667
10Myokymia (HP:0002411)2.62178080
11Hyperacusis (HP:0010780)2.55364905
12Astrocytoma (HP:0009592)2.54686251
13Abnormality of the astrocytes (HP:0100707)2.54686251
14Spinal cord lesions (HP:0100561)2.52738083
15Syringomyelia (HP:0003396)2.52738083
16Papillary thyroid carcinoma (HP:0002895)2.51541418
17Shallow orbits (HP:0000586)2.50965846
18Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.49609006
19Short 4th metacarpal (HP:0010044)2.49609006
20Dysmetric saccades (HP:0000641)2.48025035
21Acute myeloid leukemia (HP:0004808)2.46511781
22Embryonal renal neoplasm (HP:0011794)2.46489526
23Deviation of the thumb (HP:0009603)2.44784389
24Macroorchidism (HP:0000053)2.41303512
25Pointed chin (HP:0000307)2.39601305
26Action tremor (HP:0002345)2.39113275
27Insidious onset (HP:0003587)2.37774405
28Termporal pattern (HP:0011008)2.37774405
29Relative macrocephaly (HP:0004482)2.35943337
30Wrist flexion contracture (HP:0001239)2.35785506
31Visual hallucinations (HP:0002367)2.34384122
32Cerebral aneurysm (HP:0004944)2.29842131
33Osteolytic defects of the hand bones (HP:0009699)2.29049337
34Osteolytic defects of the phalanges of the hand (HP:0009771)2.29049337
35Abnormality of the lower motor neuron (HP:0002366)2.26095544
36Impaired vibration sensation in the lower limbs (HP:0002166)2.25102950
37Proximal placement of thumb (HP:0009623)2.23669426
38Abnormality of the calcaneus (HP:0008364)2.21474146
39Abnormality of the fingertips (HP:0001211)2.20158304
40Atonic seizures (HP:0010819)2.19520331
41Progressive cerebellar ataxia (HP:0002073)2.18830440
42Heterotopia (HP:0002282)2.17238988
43Missing ribs (HP:0000921)2.14714774
44Urinary urgency (HP:0000012)2.12686593
45Progressive external ophthalmoplegia (HP:0000590)2.12220881
46Selective tooth agenesis (HP:0001592)2.10820715
47Ulnar bowing (HP:0003031)2.09940601
48Narrow palate (HP:0000189)2.06098454
49Rhabdomyosarcoma (HP:0002859)2.05241824
50Ependymoma (HP:0002888)2.04372644
51Prominent nose (HP:0000448)2.03529834
52Abnormality of chromosome stability (HP:0003220)2.02277697
53Insomnia (HP:0100785)2.02248799
54Sparse lateral eyebrow (HP:0005338)2.02126545
55Overlapping toe (HP:0001845)2.02101838
56Elfin facies (HP:0004428)2.01159968
57Cafe-au-lait spot (HP:0000957)2.00686794
58Hemiplegia (HP:0002301)2.00244925
59Enlarged penis (HP:0000040)1.99481051
60Cubitus valgus (HP:0002967)1.98812805
61Dislocated radial head (HP:0003083)1.98612146
62Abnormality of the labia minora (HP:0012880)1.98495326
63Abnormality of the distal phalanx of the thumb (HP:0009617)1.97400863
64Trigonocephaly (HP:0000243)1.96927056
65Subaortic stenosis (HP:0001682)1.96830649
66Abnormality of the left ventricular outflow tract (HP:0011103)1.96830649
67Lower limb amyotrophy (HP:0007210)1.95939459
68Obsessive-compulsive behavior (HP:0000722)1.93508637
69Medulloblastoma (HP:0002885)1.93500694
70Broad-based gait (HP:0002136)1.92627355
71Cortical dysplasia (HP:0002539)1.92581537
72Subacute progressive viral hepatitis (HP:0006572)1.91991885
73Impaired smooth pursuit (HP:0007772)1.91704098
74Abnormality of the 4th metacarpal (HP:0010012)1.91516458
75High anterior hairline (HP:0009890)1.90928826
76Broad metatarsal (HP:0001783)1.90580450
77Renovascular hypertension (HP:0100817)1.90409190
78Excessive salivation (HP:0003781)1.90138865
79Drooling (HP:0002307)1.90138865
80Febrile seizures (HP:0002373)1.89744946
81Annular pancreas (HP:0001734)1.89733826
82Vertebral arch anomaly (HP:0008438)1.89541409
83Ankle clonus (HP:0011448)1.89482576
84Aqueductal stenosis (HP:0002410)1.87594154
85Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.87420028
86Difficulty running (HP:0009046)1.87024927
87Renal duplication (HP:0000075)1.86419777
88Ankyloglossia (HP:0010296)1.85944535
89Skull defect (HP:0001362)1.85811713
90Short chin (HP:0000331)1.85491667
91Cystic hygroma (HP:0000476)1.85006345
92Calcaneovalgus deformity (HP:0001848)1.84409852
93Glioma (HP:0009733)1.84283231
94Neoplasm of the oral cavity (HP:0100649)1.83273132
95Progressive muscle weakness (HP:0003323)1.83244096
96Epileptic encephalopathy (HP:0200134)1.82198415
97Neonatal hypoglycemia (HP:0001998)1.81971613
98Broad thumb (HP:0011304)1.81861093
99Sacral dimple (HP:0000960)1.81670169
100Thyroid carcinoma (HP:0002890)1.81103764
101Dysdiadochokinesis (HP:0002075)1.80806390
102Truncal obesity (HP:0001956)1.80272998
103Low anterior hairline (HP:0000294)1.80031578
104Volvulus (HP:0002580)1.79608085
105Inappropriate behavior (HP:0000719)1.79346082
106Overriding aorta (HP:0002623)1.79097761
107Overgrowth (HP:0001548)1.78466945
108Flat cornea (HP:0007720)1.78366831
109Transitional cell carcinoma of the bladder (HP:0006740)1.76461349
110Persistence of primary teeth (HP:0006335)1.74469419
111Abnormality of the radial head (HP:0003995)1.73826128
112Abnormal social behavior (HP:0012433)1.71718029
113Impaired social interactions (HP:0000735)1.71718029
114Cutis marmorata (HP:0000965)1.71496007
115Abnormality of ocular smooth pursuit (HP:0000617)1.70436314
116Bundle branch block (HP:0011710)1.69747479
117Gaze-evoked nystagmus (HP:0000640)1.69684763
118Abnormal foot bone ossification (HP:0010675)1.69494528
119Postural instability (HP:0002172)1.68553263
120Abnormality of chromosome segregation (HP:0002916)1.67761950
121Long eyelashes (HP:0000527)1.67290431
122Bowel diverticulosis (HP:0005222)1.66635729
123Absence seizures (HP:0002121)1.66096489
124Limited elbow extension (HP:0001377)1.66036867
125Papilledema (HP:0001085)1.65815738
126Hepatoblastoma (HP:0002884)1.65488731
127Neoplasm of the small intestine (HP:0100833)1.65131572
128Hypospadias (HP:0000047)1.65081685
129Mitral valve prolapse (HP:0001634)1.65010039
130Sandal gap (HP:0001852)1.64851623
131Wide nose (HP:0000445)1.64238040
132Bladder neoplasm (HP:0009725)1.64071646
133Bladder carcinoma (HP:0002862)1.64071646
134Poor eye contact (HP:0000817)1.63466028
135Facial hemangioma (HP:0000329)1.63358172
136Ankle contracture (HP:0006466)1.63264577
137Leiomyosarcoma (HP:0100243)1.63259307
138Uterine leiomyosarcoma (HP:0002891)1.63259307
139Distal lower limb amyotrophy (HP:0008944)1.63208535
140Flat acetabular roof (HP:0003180)1.62758566
141Urethral obstruction (HP:0000796)1.62616244
142Truncal ataxia (HP:0002078)1.62435086
143Neoplasm of the heart (HP:0100544)1.62052512
144Abnormality of oral frenula (HP:0000190)1.62002281
145Increased nuchal translucency (HP:0010880)1.61048161
146Dysmetria (HP:0001310)1.60699955
147Abnormality of the corticospinal tract (HP:0002492)1.59453449
148Aplasia/Hypoplasia of the sternum (HP:0006714)1.59213523
149Ectopic kidney (HP:0000086)1.58563129
150Mutism (HP:0002300)1.57725685
151Radioulnar synostosis (HP:0002974)1.57642387
152Smooth philtrum (HP:0000319)1.57299172
153Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.56234267
154Viral hepatitis (HP:0006562)1.56192705
155Advanced eruption of teeth (HP:0006288)1.56104259
156Renal cell carcinoma (HP:0005584)1.56066094
157Capillary hemangiomas (HP:0005306)1.55896479
158Arnold-Chiari malformation (HP:0002308)1.55388127
159Genu recurvatum (HP:0002816)1.55261270
160Myelodysplasia (HP:0002863)1.54671542
161Submucous cleft hard palate (HP:0000176)1.54617319
162Sudden death (HP:0001699)1.54410537
163Obstructive sleep apnea (HP:0002870)1.53566864
164Absent frontal sinuses (HP:0002688)1.52931597
165Gastrointestinal carcinoma (HP:0002672)1.52853077
166Malignant gastrointestinal tract tumors (HP:0006749)1.52853077

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.51569354
2LATS13.08498970
3LATS23.03551167
4MARK12.54314778
5MAP3K42.54175452
6NTRK32.50503120
7CDK122.30839178
8KSR22.29164493
9PAK62.27925379
10PRKD32.18647340
11PBK2.16151305
12TSSK62.12779950
13EPHA42.05744573
14TAOK12.01236595
15TYRO31.99682491
16MST1R1.95103384
17TRIB31.93151328
18KSR11.83912400
19SMG11.81566699
20SRPK11.78728533
21STK381.78523193
22SIK21.73136955
23DMPK1.67969786
24RPS6KB21.65752738
25PKN21.64819900
26CAMK1G1.63992254
27NTRK21.63695256
28MAP3K61.60222331
29MKNK11.58061584
30MET1.57940547
31RIPK11.51608161
32EEF2K1.51591537
33CDK61.49388601
34DAPK21.47281492
35ALK1.44971922
36PDGFRA1.43867960
37MINK11.42808958
38BRSK21.41497941
39MKNK21.38990099
40CDC71.32759898
41RET1.25399410
42MAP2K41.23502498
43EIF2AK31.16701368
44BUB11.16662182
45CAMKK11.13676166
46TTN1.13598879
47CAMK1D1.13441655
48RAF11.13174406
49CDK41.12298269
50PNCK1.12007007
51PDK21.11436644
52MARK21.09410617
53EIF2AK11.07642125
54FGFR41.06757130
55TRPM71.05993928
56MAP2K71.05056712
57NEK61.04551295
58MAPK131.04063947
59PASK1.03794616
60ICK1.03056750
61ATR1.03013738
62STK111.02448525
63PRKCH1.00346412
64PDGFRB0.95876218
65ERBB40.95237782
66ATM0.93729814
67AURKB0.91879007
68PAK30.90398096
69MAP3K100.89439339
70NLK0.88593156
71AKT30.87802219
72CDK70.86517095
73CDK50.84710584
74MAP3K130.84394819
75BMX0.82753967
76MAP3K70.82733781
77SGK30.82690301
78MTOR0.81013323
79NTRK10.80347991
80IRAK30.78112674
81PLK10.78021086
82WEE10.77203305
83SCYL20.76638974
84YES10.75548835
85DDR20.74939117
86PHKG20.74604143
87PHKG10.74604143
88NEK90.73188962
89STK30.70373366
90MAPK100.70346752
91CDC42BPA0.68379280
92STK38L0.68180513
93CSNK1G20.67534036
94CLK10.67477494
95MAP3K140.66980274
96NEK10.65686639
97RPS6KB10.65653002
98NEK20.65060198
99PAK20.63534274
100FGFR20.63318601
101PRKD20.62138114
102TAF10.61973306
103SGK10.61739879
104SGK20.59942650
105BRD40.57691167
106PLK40.56803254
107MAPK110.55641952
108RPS6KA30.55384475
109PLK30.54603226
110FGFR10.54388896
111MAP3K80.53863219
112PTK20.53357092
113PRKAA10.52892535
114CSNK1D0.52677220
115SIK10.52520028
116WNK10.51887506
117CHEK10.51022300
118PRPF4B0.50410296
119DAPK10.49473652
120PIM10.48892223
121MAPK140.48671446
122PRKDC0.47950776
123CDK80.47809363
124CDK150.47802391
125GSK3B0.47531091
126CSNK1E0.46222696
127CDK90.46219208
128BRSK10.46152919
129MELK0.45437298
130STK240.45153376
131RIPK40.45143112
132MAP3K20.45073549
133MAPK80.45062664
134CDK20.45012812
135MOS0.44736047
136PDK10.44722400
137CHEK20.43683339
138STK40.43080919
139CAMK10.43020533
140CDK180.42737180
141FLT30.42631141
142EIF2AK20.42439588
143FGFR30.42275866
144PLK20.42198462
145CSNK1A1L0.41253724
146TTK0.41131938
147CAMK40.40609546
148PRKD10.40337944
149DYRK1A0.40266657
150FES0.39900740
151CDK10.39257140

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041102.59397658
2DNA replication_Homo sapiens_hsa030302.48484689
3Non-homologous end-joining_Homo sapiens_hsa034502.39339576
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.21371960
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.08625588
6RNA transport_Homo sapiens_hsa030132.05611351
7Thyroid cancer_Homo sapiens_hsa052162.04028109
8Long-term potentiation_Homo sapiens_hsa047202.01735585
9Nicotine addiction_Homo sapiens_hsa050331.94584854
10Mismatch repair_Homo sapiens_hsa034301.78105701
11Circadian entrainment_Homo sapiens_hsa047131.72881925
12Olfactory transduction_Homo sapiens_hsa047401.72672572
13Glutamatergic synapse_Homo sapiens_hsa047241.71172186
14Small cell lung cancer_Homo sapiens_hsa052221.60719589
15Spliceosome_Homo sapiens_hsa030401.55157202
16Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.53169919
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.51826624
18GABAergic synapse_Homo sapiens_hsa047271.51372890
19Prostate cancer_Homo sapiens_hsa052151.51331714
20GnRH signaling pathway_Homo sapiens_hsa049121.50771024
21Glioma_Homo sapiens_hsa052141.50626169
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.50313682
23mTOR signaling pathway_Homo sapiens_hsa041501.49440863
24Dopaminergic synapse_Homo sapiens_hsa047281.49404354
25Morphine addiction_Homo sapiens_hsa050321.48949542
26Oxytocin signaling pathway_Homo sapiens_hsa049211.48110728
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.44925465
28Cholinergic synapse_Homo sapiens_hsa047251.44384102
29Type II diabetes mellitus_Homo sapiens_hsa049301.43978530
30Amphetamine addiction_Homo sapiens_hsa050311.43021538
31Dorso-ventral axis formation_Homo sapiens_hsa043201.42070928
32Synaptic vesicle cycle_Homo sapiens_hsa047211.39092500
33Endometrial cancer_Homo sapiens_hsa052131.39052513
34Estrogen signaling pathway_Homo sapiens_hsa049151.34253714
35Acute myeloid leukemia_Homo sapiens_hsa052211.32351238
36Long-term depression_Homo sapiens_hsa047301.32096357
37Salivary secretion_Homo sapiens_hsa049701.31651998
38Dilated cardiomyopathy_Homo sapiens_hsa054141.31345360
39ErbB signaling pathway_Homo sapiens_hsa040121.31317853
40Thyroid hormone signaling pathway_Homo sapiens_hsa049191.31169277
41Colorectal cancer_Homo sapiens_hsa052101.28379456
42Insulin secretion_Homo sapiens_hsa049111.27705541
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.26388330
44Gastric acid secretion_Homo sapiens_hsa049711.26290535
45Viral carcinogenesis_Homo sapiens_hsa052031.24420209
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.21891493
47Gap junction_Homo sapiens_hsa045401.21769656
48Nucleotide excision repair_Homo sapiens_hsa034201.21532050
49Non-small cell lung cancer_Homo sapiens_hsa052231.21072806
50Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.20903412
51Phosphatidylinositol signaling system_Homo sapiens_hsa040701.20783050
52Renal cell carcinoma_Homo sapiens_hsa052111.20089751
53Oocyte meiosis_Homo sapiens_hsa041141.17462654
54One carbon pool by folate_Homo sapiens_hsa006701.17229878
55cAMP signaling pathway_Homo sapiens_hsa040241.15431901
56Axon guidance_Homo sapiens_hsa043601.15013936
57Renin secretion_Homo sapiens_hsa049241.14719738
58Chronic myeloid leukemia_Homo sapiens_hsa052201.12697845
59Neurotrophin signaling pathway_Homo sapiens_hsa047221.11215859
60VEGF signaling pathway_Homo sapiens_hsa043701.10791531
61Choline metabolism in cancer_Homo sapiens_hsa052311.10149517
62cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09937330
63Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.08480137
64Phospholipase D signaling pathway_Homo sapiens_hsa040721.07739395
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.07739095
66Pancreatic cancer_Homo sapiens_hsa052121.05717307
67MAPK signaling pathway_Homo sapiens_hsa040101.02985812
68Cocaine addiction_Homo sapiens_hsa050301.02752136
69Longevity regulating pathway - mammal_Homo sapiens_hsa042111.00921583
70Hepatitis B_Homo sapiens_hsa051610.99600189
71MicroRNAs in cancer_Homo sapiens_hsa052060.99208150
72Melanogenesis_Homo sapiens_hsa049160.98682507
73Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.97806019
74Calcium signaling pathway_Homo sapiens_hsa040200.97516159
75Adherens junction_Homo sapiens_hsa045200.97369845
76Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.96943783
77Bladder cancer_Homo sapiens_hsa052190.96086808
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.93597891
79Proteoglycans in cancer_Homo sapiens_hsa052050.92334426
80Selenocompound metabolism_Homo sapiens_hsa004500.90227839
81Lysine degradation_Homo sapiens_hsa003100.89860746
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.89488601
83Taste transduction_Homo sapiens_hsa047420.88375537
84Focal adhesion_Homo sapiens_hsa045100.87661765
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87387081
86Rap1 signaling pathway_Homo sapiens_hsa040150.86288763
87Hippo signaling pathway_Homo sapiens_hsa043900.85381421
88Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.85293679
89HTLV-I infection_Homo sapiens_hsa051660.84627274
90Wnt signaling pathway_Homo sapiens_hsa043100.84100280
91Base excision repair_Homo sapiens_hsa034100.83910686
92Fanconi anemia pathway_Homo sapiens_hsa034600.83439519
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.83073670
94Pathways in cancer_Homo sapiens_hsa052000.81913732
95p53 signaling pathway_Homo sapiens_hsa041150.80950230
96Prolactin signaling pathway_Homo sapiens_hsa049170.80939619
97Serotonergic synapse_Homo sapiens_hsa047260.80519946
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.80110364
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.79643236
100Melanoma_Homo sapiens_hsa052180.78969029
101Insulin signaling pathway_Homo sapiens_hsa049100.78716908
102Viral myocarditis_Homo sapiens_hsa054160.78579276
103Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76663467
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76492125
105Circadian rhythm_Homo sapiens_hsa047100.76231905
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.75733832
107B cell receptor signaling pathway_Homo sapiens_hsa046620.75021230
108Vitamin B6 metabolism_Homo sapiens_hsa007500.74797427
109mRNA surveillance pathway_Homo sapiens_hsa030150.73337722
110Ras signaling pathway_Homo sapiens_hsa040140.73219096
111Biosynthesis of amino acids_Homo sapiens_hsa012300.72675367
112Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72252810
113Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.71117449
114AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70736572
115FoxO signaling pathway_Homo sapiens_hsa040680.70450545
116Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69757139
117RNA degradation_Homo sapiens_hsa030180.69589759
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69395425
119Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69348445
120Platelet activation_Homo sapiens_hsa046110.69174047
121Basal cell carcinoma_Homo sapiens_hsa052170.68453326
122Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67982322
123Inositol phosphate metabolism_Homo sapiens_hsa005620.67092739
124Glucagon signaling pathway_Homo sapiens_hsa049220.66826354
125Measles_Homo sapiens_hsa051620.66712791
126Tight junction_Homo sapiens_hsa045300.66124584
127Hedgehog signaling pathway_Homo sapiens_hsa043400.65670789
128Alcoholism_Homo sapiens_hsa050340.63969472
129Basal transcription factors_Homo sapiens_hsa030220.63524069
130ECM-receptor interaction_Homo sapiens_hsa045120.63205464
131Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.63091022
132TGF-beta signaling pathway_Homo sapiens_hsa043500.62867450
133AMPK signaling pathway_Homo sapiens_hsa041520.62636701
134Notch signaling pathway_Homo sapiens_hsa043300.62407680
135Insulin resistance_Homo sapiens_hsa049310.62004980
136Sphingolipid signaling pathway_Homo sapiens_hsa040710.61522057
137HIF-1 signaling pathway_Homo sapiens_hsa040660.61438553
138Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60461668
139Chemokine signaling pathway_Homo sapiens_hsa040620.60277408
140T cell receptor signaling pathway_Homo sapiens_hsa046600.58911949
141Hepatitis C_Homo sapiens_hsa051600.58561056
142Systemic lupus erythematosus_Homo sapiens_hsa053220.57163080
143Amoebiasis_Homo sapiens_hsa051460.57015824
144Herpes simplex infection_Homo sapiens_hsa051680.56222579
145Homologous recombination_Homo sapiens_hsa034400.54553231
146Apoptosis_Homo sapiens_hsa042100.53818236
147Epstein-Barr virus infection_Homo sapiens_hsa051690.52889948

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