ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of response to food (GO:0032096)	6.38036659
2	negative regulation of appetite (GO:0032099)	6.38036659
3	behavioral response to nicotine (GO:0035095)	6.26188841
4	negative regulation of heart rate (GO:0010459)	5.27217032
5	snRNA transcription (GO:0009301)	4.88211920
6	signal peptide processing (GO:0006465)	4.75944013
7	interkinetic nuclear migration (GO:0022027)	4.73037606
8	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.52712991
9	protein polyglutamylation (GO:0018095)	4.42591845
10	regulation of pigment cell differentiation (GO:0050932)	4.39495873
11	cellular ketone body metabolic process (GO:0046950)	4.19327965
12	nucleotide transmembrane transport (GO:1901679)	4.11453763
13	translational termination (GO:0006415)	4.08425504
14	GMP metabolic process (GO:0046037)	3.93922246
15	G-protein coupled receptor internalization (GO:0002031)	3.89949554
16	epithelial cilium movement (GO:0003351)	3.80451731
17	viral transcription (GO:0019083)	3.79289368
18	positive regulation of developmental pigmentation (GO:0048087)	3.76406506
19	protein neddylation (GO:0045116)	3.75882074
20	ketone body metabolic process (GO:1902224)	3.68810846
21	regulation of response to food (GO:0032095)	3.60575106
22	regulation of appetite (GO:0032098)	3.46176052
23	regulation of cilium movement (GO:0003352)	3.44689229
24	tryptophan catabolic process (GO:0006569)	3.37167771
25	indole-containing compound catabolic process (GO:0042436)	3.37167771
26	indolalkylamine catabolic process (GO:0046218)	3.37167771
27	microtubule severing (GO:0051013)	3.36848503
28	positive regulation of DNA repair (GO:0045739)	3.34671008
29	sleep (GO:0030431)	3.30531040
30	translational elongation (GO:0006414)	3.25558424
31	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.19893505
32	cotranslational protein targeting to membrane (GO:0006613)	3.15477081
33	negative regulation of peptidyl-threonine phosphorylation (GO:0010801)	3.13359273
34	kynurenine metabolic process (GO:0070189)	3.12989465
35	protein targeting to ER (GO:0045047)	3.09668191
36	indolalkylamine metabolic process (GO:0006586)	3.08097115
37	DNA deamination (GO:0045006)	3.07891975
38	cellular protein complex disassembly (GO:0043624)	3.07095352
39	cilium movement (GO:0003341)	3.06482071
40	cytokine biosynthetic process (GO:0042089)	3.03157013
41	regulation of translational termination (GO:0006449)	3.01770466
42	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.01602613
43	negative regulation of neurotransmitter transport (GO:0051589)	3.01121167
44	regulation of memory T cell differentiation (GO:0043380)	2.99434154
45	amine catabolic process (GO:0009310)	2.97797262
46	cellular biogenic amine catabolic process (GO:0042402)	2.97797262
47	head development (GO:0060322)	2.97227501
48	mature B cell differentiation involved in immune response (GO:0002313)	2.97057317
49	ribosomal small subunit assembly (GO:0000028)	2.94951028
50	regulation of female gonad development (GO:2000194)	2.93907010
51	ribosomal large subunit biogenesis (GO:0042273)	2.91755418
52	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.91649266
53	viral life cycle (GO:0019058)	2.89537686
54	poly(A)+ mRNA export from nucleus (GO:0016973)	2.88848725
55	protein localization to endoplasmic reticulum (GO:0070972)	2.88297615
56	protein prenylation (GO:0018342)	2.87587047
57	prenylation (GO:0097354)	2.87587047
58	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.86325741
59	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.85406058
60	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.85406058
61	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.83617682
62	ATP synthesis coupled proton transport (GO:0015986)	2.83617682
63	definitive hemopoiesis (GO:0060216)	2.82471836
64	aromatic amino acid family catabolic process (GO:0009074)	2.80505756
65	mature B cell differentiation (GO:0002335)	2.79182586
66	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.78331690
67	parturition (GO:0007567)	2.77922631
68	negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)	2.72568867
69	regulation of MHC class II biosynthetic process (GO:0045346)	2.71935378
70	base-excision repair, AP site formation (GO:0006285)	2.68902756
71	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	2.68544851
72	negative regulation of T-helper cell differentiation (GO:0045623)	2.68544851
73	regulation of RIG-I signaling pathway (GO:0039535)	2.65993826
74	anterograde synaptic vesicle transport (GO:0048490)	2.65689177
75	polyol catabolic process (GO:0046174)	2.63864474
76	axoneme assembly (GO:0035082)	2.63548195
77	negative regulation of neurotransmitter secretion (GO:0046929)	2.61138345
78	positive regulation of activated T cell proliferation (GO:0042104)	2.60378121
79	negative regulation of response to nutrient levels (GO:0032108)	2.59812417
80	negative regulation of response to extracellular stimulus (GO:0032105)	2.59812417
81	translational initiation (GO:0006413)	2.59169138
82	rhodopsin mediated signaling pathway (GO:0016056)	2.58994547
83	regulation of sensory perception (GO:0051931)	2.58347113
84	regulation of sensory perception of pain (GO:0051930)	2.58347113
85	protein complex disassembly (GO:0043241)	2.56888854
86	macromolecular complex disassembly (GO:0032984)	2.56393002
87	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.54690784
88	gland morphogenesis (GO:0022612)	2.53878886
89	organelle membrane fusion (GO:0090174)	2.52891844
90	reciprocal meiotic recombination (GO:0007131)	2.52216929
91	reciprocal DNA recombination (GO:0035825)	2.52216929
92	platelet dense granule organization (GO:0060155)	2.52130970
93	negative regulation by host of viral transcription (GO:0043922)	2.51153274
94	parental behavior (GO:0060746)	2.50508796
95	ribonucleoprotein complex disassembly (GO:0032988)	2.49897336
96	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	2.49675884
97	intra-S DNA damage checkpoint (GO:0031573)	2.48260812
98	regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)	2.47984750
99	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.47169271
100	negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)	2.46105151

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IGF1R_20145208_ChIP-Seq_DFB_Human	2.80197516
2	FUS_26573619_Chip-Seq_HEK293_Human	2.80045192
3	GBX2_23144817_ChIP-Seq_PC3_Human	2.69744317
4	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.68791348
5	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.61350423
6	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.60819175
7	TAF15_26573619_Chip-Seq_HEK293_Human	2.56568103
8	EZH2_22144423_ChIP-Seq_EOC_Human	2.50616837
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.39151881
10	VDR_22108803_ChIP-Seq_LS180_Human	2.31469477
11	EWS_26573619_Chip-Seq_HEK293_Human	2.24269382
12	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.23988663
13	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.22802783
14	ZNF274_21170338_ChIP-Seq_K562_Hela	2.16688063
15	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.15872570
16	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.10098251
17	ELK1_19687146_ChIP-ChIP_HELA_Human	2.08058108
18	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.06374083
19	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.97696748
20	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.96111431
21	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.88923461
22	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.85714577
23	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.84087277
24	IRF1_19129219_ChIP-ChIP_H3396_Human	1.81707231
25	ER_23166858_ChIP-Seq_MCF-7_Human	1.74721044
26	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.73662862
27	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.71773348
28	P300_19829295_ChIP-Seq_ESCs_Human	1.71438745
29	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.69837843
30	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.60416780
31	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.60416780
32	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.56403597
33	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.55669424
34	NANOG_19829295_ChIP-Seq_ESCs_Human	1.55625532
35	SOX2_19829295_ChIP-Seq_ESCs_Human	1.55625532
36	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.54841680
37	MYC_18940864_ChIP-ChIP_HL60_Human	1.53765198
38	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.52407806
39	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.51460351
40	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.49141782
41	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.47626790
42	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.46143852
43	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.42286295
44	VDR_23849224_ChIP-Seq_CD4+_Human	1.40439935
45	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.38667794
46	TP53_22573176_ChIP-Seq_HFKS_Human	1.36929288
47	AR_25329375_ChIP-Seq_VCAP_Human	1.34738901
48	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.34615684
49	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.34279616
50	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.33494038
51	SMAD4_21799915_ChIP-Seq_A2780_Human	1.31747264
52	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.29932511
53	RNF2_27304074_Chip-Seq_NSC_Mouse	1.27988000
54	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.27111083
55	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.26895861
56	STAT3_23295773_ChIP-Seq_U87_Human	1.25933891
57	BCAT_22108803_ChIP-Seq_LS180_Human	1.25619971
58	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.23379819
59	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.22820960
60	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.22403216
61	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.20180510
62	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.19664515
63	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.19651955
64	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.19518700
65	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.19034704
66	NCOR_22424771_ChIP-Seq_293T_Human	1.18199051
67	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.17247219
68	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.17089169
69	TCF4_23295773_ChIP-Seq_U87_Human	1.16964939
70	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.16299756
71	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.12276730
72	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.10485312
73	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.08565258
74	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.06510907
75	TCF4_22108803_ChIP-Seq_LS180_Human	1.06419994
76	HOXB7_26014856_ChIP-Seq_BT474_Human	1.06066701
77	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.05008082
78	P53_22387025_ChIP-Seq_ESCs_Mouse	1.04967093
79	REST_21632747_ChIP-Seq_MESCs_Mouse	1.02461257
80	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01201867
81	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.00353989
82	TBL1_22424771_ChIP-Seq_293T_Human	0.98512302
83	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.98444615
84	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.97462740
85	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.95404470
86	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.95373004
87	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.95343609
88	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.95065449
89	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.94736539
90	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.94345336
91	GATA1_22025678_ChIP-Seq_K562_Human	0.94016868
92	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.93658613
93	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.93575661
94	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.93049000
95	AR_20517297_ChIP-Seq_VCAP_Human	0.91649577
96	TAF2_19829295_ChIP-Seq_ESCs_Human	0.91128165
97	ERG_20517297_ChIP-Seq_VCAP_Human	0.90385540
98	RUNX2_22187159_ChIP-Seq_PCA_Human	0.89361046
99	CBP_21632823_ChIP-Seq_H3396_Human	0.89102975
100	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.88274687

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002160_abnormal_reproductive_system	4.42879572
2	MP0004147_increased_porphyrin_level	3.87262072
3	MP0001188_hyperpigmentation	3.32672320
4	MP0009379_abnormal_foot_pigmentation	3.14320856
5	MP0003136_yellow_coat_color	2.98821395
6	MP0010386_abnormal_urinary_bladder	2.69988148
7	MP0003123_paternal_imprinting	2.68421062
8	MP0003787_abnormal_imprinting	2.57288014
9	MP0005389_reproductive_system_phenotype	2.51450829
10	MP0004885_abnormal_endolymph	2.41807595
11	MP0005075_abnormal_melanosome_morpholog	2.40128256
12	MP0000569_abnormal_digit_pigmentation	2.38928389
13	MP0003718_maternal_effect	2.29674368
14	MP0006276_abnormal_autonomic_nervous	2.26933115
15	MP0005464_abnormal_platelet_physiology	2.19645036
16	MP0005174_abnormal_tail_pigmentation	2.10038217
17	MP0008877_abnormal_DNA_methylation	2.05897594
18	MP0001485_abnormal_pinna_reflex	2.05423521
19	MP0003878_abnormal_ear_physiology	1.99033825
20	MP0005377_hearing/vestibular/ear_phenot	1.99033825
21	MP0003011_delayed_dark_adaptation	1.95253632
22	MP0002638_abnormal_pupillary_reflex	1.94083376
23	MP0006292_abnormal_olfactory_placode	1.89962450
24	MP0001664_abnormal_digestion	1.86337775
25	MP0005410_abnormal_fertilization	1.81494196
26	MP0002837_dystrophic_cardiac_calcinosis	1.77571180
27	MP0006072_abnormal_retinal_apoptosis	1.77362831
28	MP0004130_abnormal_muscle_cell	1.75224766
29	MP0002938_white_spotting	1.71184134
30	MP0008872_abnormal_physiological_respon	1.68643836
31	MP0002736_abnormal_nociception_after	1.66215792
32	MP0005551_abnormal_eye_electrophysiolog	1.65717674
33	MP0008004_abnormal_stomach_pH	1.63772910
34	MP0001873_stomach_inflammation	1.58533686
35	MP0002876_abnormal_thyroid_physiology	1.55069171
36	MP0000230_abnormal_systemic_arterial	1.53817603
37	MP0004134_abnormal_chest_morphology	1.53655646
38	MP0002095_abnormal_skin_pigmentation	1.51938145
39	MP0002272_abnormal_nervous_system	1.44741999
40	MP0002234_abnormal_pharynx_morphology	1.43055434
41	MP0004381_abnormal_hair_follicle	1.42869447
42	MP0005084_abnormal_gallbladder_morpholo	1.38518350
43	MP0000372_irregular_coat_pigmentation	1.38303079
44	MP0005253_abnormal_eye_physiology	1.38195056
45	MP0003950_abnormal_plasma_membrane	1.32702292
46	MP0002909_abnormal_adrenal_gland	1.29623748
47	MP0003890_abnormal_embryonic-extraembry	1.25081556
48	MP0001501_abnormal_sleep_pattern	1.22885471
49	MP0003119_abnormal_digestive_system	1.22366601
50	MP0001968_abnormal_touch/_nociception	1.20465432
51	MP0005645_abnormal_hypothalamus_physiol	1.17487514
52	MP0003880_abnormal_central_pattern	1.15141515
53	MP0010329_abnormal_lipoprotein_level	1.14765962
54	MP0000465_gastrointestinal_hemorrhage	1.10722971
55	MP0005670_abnormal_white_adipose	1.09740747
56	MP0003186_abnormal_redox_activity	1.05735105
57	MP0001970_abnormal_pain_threshold	1.05418881
58	MP0005448_abnormal_energy_balance	1.04832060
59	MP0003806_abnormal_nucleotide_metabolis	1.04545269
60	MP0002693_abnormal_pancreas_physiology	1.02616591
61	MP0002928_abnormal_bile_duct	1.00854341
62	MP0005310_abnormal_salivary_gland	0.96185153
63	MP0004145_abnormal_muscle_electrophysio	0.93934614
64	MP0001293_anophthalmia	0.93659736
65	MP0009046_muscle_twitch	0.92762585
66	MP0009745_abnormal_behavioral_response	0.90945227
67	MP0006036_abnormal_mitochondrial_physio	0.90809169
68	MP0005167_abnormal_blood-brain_barrier	0.90804191
69	MP0001905_abnormal_dopamine_level	0.90220144
70	MP0002557_abnormal_social/conspecific_i	0.88787851
71	MP0002396_abnormal_hematopoietic_system	0.87187003
72	MP0004133_heterotaxia	0.86628982
73	MP0002210_abnormal_sex_determination	0.85221756
74	MP0000631_abnormal_neuroendocrine_gland	0.84148137
75	MP0003121_genomic_imprinting	0.82757026
76	MP0004043_abnormal_pH_regulation	0.81452043
77	MP0004742_abnormal_vestibular_system	0.80697485
78	MP0005535_abnormal_body_temperature	0.80231899
79	MP0003724_increased_susceptibility_to	0.78305911
80	MP0001529_abnormal_vocalization	0.77184452
81	MP0005085_abnormal_gallbladder_physiolo	0.77001420
82	MP0004142_abnormal_muscle_tone	0.76895223
83	MP0003698_abnormal_male_reproductive	0.76670102
84	MP0000538_abnormal_urinary_bladder	0.76188679
85	MP0001879_abnormal_lymphatic_vessel	0.75927737
86	MP0001919_abnormal_reproductive_system	0.75194190
87	MP0001663_abnormal_digestive_system	0.73969864
88	MP0008775_abnormal_heart_ventricle	0.73230892
89	MP0003195_calcinosis	0.72384208
90	MP0002067_abnormal_sensory_capabilities	0.71820347
91	MP0001764_abnormal_homeostasis	0.71279169
92	MP0001756_abnormal_urination	0.68323082
93	MP0004215_abnormal_myocardial_fiber	0.67323923
94	MP0005646_abnormal_pituitary_gland	0.67234588
95	MP0005266_abnormal_metabolism	0.67163100
96	MP0002733_abnormal_thermal_nociception	0.66914164
97	MP0004924_abnormal_behavior	0.66213830
98	MP0005386_behavior/neurological_phenoty	0.66213830
99	MP0005332_abnormal_amino_acid	0.65609982
100	MP0003879_abnormal_hair_cell	0.65341903

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Lipid accumulation in hepatocytes (HP:0006561)	4.38332381
2	Increased hepatocellular lipid droplets (HP:0006565)	3.94425614
3	Pancreatic fibrosis (HP:0100732)	3.86775801
4	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.75434539
5	Aplasia/Hypoplasia of the tibia (HP:0005772)	3.72305935
6	Abnormal ciliary motility (HP:0012262)	3.70865938
7	Congenital, generalized hypertrichosis (HP:0004540)	3.63024318
8	Abnormal respiratory motile cilium morphology (HP:0005938)	3.57103138
9	Abnormal respiratory epithelium morphology (HP:0012253)	3.57103138
10	Renal Fanconi syndrome (HP:0001994)	3.55099530
11	Pancreatic cysts (HP:0001737)	3.50694787
12	True hermaphroditism (HP:0010459)	3.38034732
13	Decreased central vision (HP:0007663)	3.24676514
14	Congenital stationary night blindness (HP:0007642)	3.15729262
15	Agitation (HP:0000713)	3.04392521
16	Abnormal rod and cone electroretinograms (HP:0008323)	2.99857583
17	Hyperglycinemia (HP:0002154)	2.99480520
18	Absent/shortened dynein arms (HP:0200106)	2.94119237
19	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.94119237
20	Short tibia (HP:0005736)	2.92374896
21	Prolonged bleeding time (HP:0003010)	2.88936369
22	Medial flaring of the eyebrow (HP:0010747)	2.86845998
23	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.81358867
24	Papilledema (HP:0001085)	2.79448515
25	Abnormal respiratory motile cilium physiology (HP:0012261)	2.73825501
26	Metaphyseal dysplasia (HP:0100255)	2.70177322
27	Molar tooth sign on MRI (HP:0002419)	2.68891971
28	Abnormality of midbrain morphology (HP:0002418)	2.68891971
29	Congenital primary aphakia (HP:0007707)	2.66520849
30	Exertional dyspnea (HP:0002875)	2.65829207
31	Respiratory difficulties (HP:0002880)	2.65158786
32	Increased CSF lactate (HP:0002490)	2.64045592
33	Gait imbalance (HP:0002141)	2.63163516
34	Acute lymphatic leukemia (HP:0006721)	2.63012484
35	Nephrogenic diabetes insipidus (HP:0009806)	2.59476313
36	Attenuation of retinal blood vessels (HP:0007843)	2.48404804
37	Mitochondrial inheritance (HP:0001427)	2.41469278
38	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.41209967
39	Arthropathy (HP:0003040)	2.35667735
40	Thyroid-stimulating hormone excess (HP:0002925)	2.34629693
41	Cerebral palsy (HP:0100021)	2.33006521
42	Congenital hepatic fibrosis (HP:0002612)	2.29619675
43	Abnormality of the renal cortex (HP:0011035)	2.28093293
44	Asplenia (HP:0001746)	2.27921758
45	Metabolic alkalosis (HP:0200114)	2.24496688
46	Anencephaly (HP:0002323)	2.22264452
47	Chronic sinusitis (HP:0011109)	2.22005941
48	Dyschromatopsia (HP:0007641)	2.21741286
49	Rhinitis (HP:0012384)	2.21374351
50	Progressive microcephaly (HP:0000253)	2.16150388
51	Increased muscle lipid content (HP:0009058)	2.15093180
52	Abnormality of renal resorption (HP:0011038)	2.09775562
53	Renal cortical cysts (HP:0000803)	2.09065628
54	Cystic liver disease (HP:0006706)	2.08726374
55	Genital tract atresia (HP:0001827)	2.08563568
56	Abnormality of the labia minora (HP:0012880)	2.05560234
57	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.04467316
58	Abnormality of alanine metabolism (HP:0010916)	2.04467316
59	Hyperalaninemia (HP:0003348)	2.04467316
60	Genetic anticipation (HP:0003743)	2.04046835
61	Increased intramyocellular lipid droplets (HP:0012240)	2.01996067
62	Abnormality of the pubic bones (HP:0003172)	2.01132902
63	Abnormality of the renal medulla (HP:0100957)	1.99713890
64	Protruding tongue (HP:0010808)	1.97869269
65	Nephronophthisis (HP:0000090)	1.97644631
66	Large for gestational age (HP:0001520)	1.96551651
67	Hypoplasia of the pons (HP:0012110)	1.92205081
68	Short hallux (HP:0010109)	1.92110408
69	Vaginal atresia (HP:0000148)	1.91717037
70	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.89223186
71	Hyperphosphaturia (HP:0003109)	1.89059529
72	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.88740137
73	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.88614576
74	Neonatal respiratory distress (HP:0002643)	1.88605862
75	Menstrual irregularities (HP:0000858)	1.88324563
76	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.86456980
77	Acute encephalopathy (HP:0006846)	1.86179046
78	Abnormal pupillary function (HP:0007686)	1.85561129
79	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.85482080
80	Acute necrotizing encephalopathy (HP:0006965)	1.84023842
81	Hypoplastic ischia (HP:0003175)	1.82574883
82	Abnormality of the pons (HP:0007361)	1.81176592
83	Glycosuria (HP:0003076)	1.79792541
84	Abnormality of urine glucose concentration (HP:0011016)	1.79792541
85	Aplasia/Hypoplasia of the hallux (HP:0008362)	1.78540802
86	Abnormal platelet volume (HP:0011876)	1.77450370
87	Furrowed tongue (HP:0000221)	1.77375175
88	Aplasia/Hypoplasia of the patella (HP:0006498)	1.76043091
89	Sclerocornea (HP:0000647)	1.74554120
90	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.74153974
91	Febrile seizures (HP:0002373)	1.72954777
92	Left ventricular hypertrophy (HP:0001712)	1.72855987
93	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.72361152
94	Pendular nystagmus (HP:0012043)	1.72063572
95	Decreased circulating renin level (HP:0003351)	1.71738810
96	Increased mean platelet volume (HP:0011877)	1.71635010
97	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	1.70498046
98	Mesomelia (HP:0003027)	1.70007368
99	Male pseudohermaphroditism (HP:0000037)	1.69782571
100	Gaze-evoked nystagmus (HP:0000640)	1.69622156

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	7.90744546
2	FRK	5.18811045
3	CAMKK2	4.44152495
4	ACVR1B	3.01392975
5	TAF1	2.57811261
6	TNIK	2.34119156
7	ADRBK2	2.27130339
8	BMPR1B	2.26306848
9	ZAK	2.04553939
10	TAOK3	1.84277324
11	NUAK1	1.76981962
12	TLK1	1.66653730
13	EPHA4	1.57878061
14	ADRBK1	1.45853475
15	TRIM28	1.45403094
16	PASK	1.42957689
17	AKT3	1.37277544
18	CAMKK1	1.32987963
19	CDC7	1.21925307
20	VRK1	1.20583123
21	TXK	1.20189272
22	BRSK2	1.19070972
23	SRPK1	1.18277892
24	MST4	1.17861514
25	VRK2	1.15474409
26	WNK3	1.13454691
27	TGFBR1	1.11996740
28	DYRK3	1.11873927
29	TEC	1.08206605
30	IRAK3	0.99587514
31	MKNK1	0.94577518
32	CAMK1	0.92831661
33	PINK1	0.89023584
34	BRAF	0.88604623
35	STK3	0.87292903
36	STK24	0.87265717
37	GRK1	0.83623637
38	GRK7	0.81853864
39	PNCK	0.75161925
40	BMPR2	0.73721440
41	CASK	0.72200056
42	MAP3K6	0.69412512
43	BTK	0.69017245
44	STK16	0.66463497
45	PDK2	0.66350220
46	IKBKB	0.66139226
47	EIF2AK1	0.64175471
48	RPS6KA4	0.64104863
49	PBK	0.62658350
50	PRKCQ	0.62418969
51	FLT3	0.61337461
52	EIF2AK3	0.60389401
53	CDK19	0.60292840
54	GRK5	0.59893175
55	STK39	0.58718413
56	WNK4	0.57962220
57	ARAF	0.57385502
58	OXSR1	0.57104107
59	MAP2K6	0.56882966
60	MINK1	0.56624768
61	MYLK	0.56290997
62	MKNK2	0.54055387
63	PAK3	0.53606492
64	PTK2B	0.53579662
65	ERBB3	0.52133069
66	ILK	0.51956395
67	MATK	0.51763517
68	MAP3K13	0.48591420
69	NEK2	0.48380161
70	INSRR	0.48283511
71	PLK2	0.46649746
72	CCNB1	0.44489775
73	DMPK	0.44103072
74	RPS6KA5	0.43531865
75	PLK3	0.42817914
76	IRAK1	0.41992270
77	SGK2	0.39127731
78	CAMK1G	0.38801566
79	CSNK1A1	0.37984711
80	PRKCG	0.35626401
81	SYK	0.35407262
82	MAPK4	0.35225043
83	FES	0.35175583
84	PRKCE	0.35091261
85	NME1	0.33890506
86	CSNK1G3	0.33590889
87	PRKG1	0.32469231
88	DAPK2	0.31500839
89	RPS6KA6	0.30641390
90	CAMK2A	0.30481117
91	RIPK4	0.30313170
92	HCK	0.30203659
93	STK4	0.30194550
94	ITK	0.29341107
95	CSNK1G2	0.29211647
96	AURKA	0.28672986
97	CDK3	0.28609208
98	CAMK4	0.28409828
99	CSF1R	0.28305613
100	PRKACA	0.28156938

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	3.47589660
2	Butanoate metabolism_Homo sapiens_hsa00650	3.34382831
3	Ribosome_Homo sapiens_hsa03010	3.34041025
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.14536945
5	Linoleic acid metabolism_Homo sapiens_hsa00591	2.97565280
6	Phototransduction_Homo sapiens_hsa04744	2.17197618
7	Tryptophan metabolism_Homo sapiens_hsa00380	2.17186903
8	Selenocompound metabolism_Homo sapiens_hsa00450	2.16769233
9	Oxidative phosphorylation_Homo sapiens_hsa00190	2.14415633
10	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.06913550
11	Protein export_Homo sapiens_hsa03060	1.99762294
12	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.91769607
13	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.89241296
14	Sulfur metabolism_Homo sapiens_hsa00920	1.84166334
15	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.83098302
16	Homologous recombination_Homo sapiens_hsa03440	1.81044065
17	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.81009029
18	Parkinsons disease_Homo sapiens_hsa05012	1.71318653
19	Fat digestion and absorption_Homo sapiens_hsa04975	1.67790933
20	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.64727861
21	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.56068523
22	One carbon pool by folate_Homo sapiens_hsa00670	1.53795330
23	Nitrogen metabolism_Homo sapiens_hsa00910	1.52728395
24	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.48310357
25	Glycerolipid metabolism_Homo sapiens_hsa00561	1.45453832
26	Basal transcription factors_Homo sapiens_hsa03022	1.43469941
27	Sulfur relay system_Homo sapiens_hsa04122	1.34652630
28	Huntingtons disease_Homo sapiens_hsa05016	1.32724093
29	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.28647644
30	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.28184573
31	Sphingolipid metabolism_Homo sapiens_hsa00600	1.26833940
32	Ether lipid metabolism_Homo sapiens_hsa00565	1.23590773
33	Serotonergic synapse_Homo sapiens_hsa04726	1.23391809
34	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.22993312
35	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.20254648
36	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.12470780
37	Fatty acid degradation_Homo sapiens_hsa00071	1.09141234
38	Peroxisome_Homo sapiens_hsa04146	1.08460140
39	Retinol metabolism_Homo sapiens_hsa00830	1.05152477
40	Propanoate metabolism_Homo sapiens_hsa00640	1.04438415
41	Olfactory transduction_Homo sapiens_hsa04740	1.00995276
42	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.99945905
43	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.96732591
44	Alzheimers disease_Homo sapiens_hsa05010	0.96682981
45	ABC transporters_Homo sapiens_hsa02010	0.95894790
46	Cardiac muscle contraction_Homo sapiens_hsa04260	0.94485795
47	Glutathione metabolism_Homo sapiens_hsa00480	0.92921346
48	RNA polymerase_Homo sapiens_hsa03020	0.92843914
49	Nicotine addiction_Homo sapiens_hsa05033	0.91953017
50	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.91045575
51	Insulin secretion_Homo sapiens_hsa04911	0.90933661
52	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.90912771
53	Pyrimidine metabolism_Homo sapiens_hsa00240	0.90242757
54	Chemical carcinogenesis_Homo sapiens_hsa05204	0.89203241
55	Salivary secretion_Homo sapiens_hsa04970	0.86583700
56	Morphine addiction_Homo sapiens_hsa05032	0.86087389
57	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.84508631
58	Steroid biosynthesis_Homo sapiens_hsa00100	0.84166471
59	Purine metabolism_Homo sapiens_hsa00230	0.82113835
60	Alcoholism_Homo sapiens_hsa05034	0.81550718
61	Glutamatergic synapse_Homo sapiens_hsa04724	0.80723489
62	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.78784161
63	Long-term depression_Homo sapiens_hsa04730	0.77420451
64	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.77285749
65	Histidine metabolism_Homo sapiens_hsa00340	0.75794108
66	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.74982320
67	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.74770971
68	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.74560480
69	Fatty acid metabolism_Homo sapiens_hsa01212	0.74342890
70	Metabolic pathways_Homo sapiens_hsa01100	0.64606180
71	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.64454035
72	Platelet activation_Homo sapiens_hsa04611	0.63890671
73	Taste transduction_Homo sapiens_hsa04742	0.63869088
74	Pyruvate metabolism_Homo sapiens_hsa00620	0.63208330
75	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.62698749
76	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.61182393
77	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.60745038
78	Pancreatic secretion_Homo sapiens_hsa04972	0.59407212
79	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.59183141
80	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.58166189
81	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.57261144
82	Nucleotide excision repair_Homo sapiens_hsa03420	0.56129694
83	Base excision repair_Homo sapiens_hsa03410	0.52849548
84	Circadian entrainment_Homo sapiens_hsa04713	0.52428882
85	beta-Alanine metabolism_Homo sapiens_hsa00410	0.51392010
86	Type I diabetes mellitus_Homo sapiens_hsa04940	0.51305301
87	Cholinergic synapse_Homo sapiens_hsa04725	0.49925078
88	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.49884179
89	RNA degradation_Homo sapiens_hsa03018	0.49493313
90	GABAergic synapse_Homo sapiens_hsa04727	0.49054946
91	Calcium signaling pathway_Homo sapiens_hsa04020	0.48688296
92	Amphetamine addiction_Homo sapiens_hsa05031	0.46494464
93	Proteasome_Homo sapiens_hsa03050	0.46083387
94	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.37333964
95	RNA transport_Homo sapiens_hsa03013	0.36812975
96	Regulation of autophagy_Homo sapiens_hsa04140	0.36528472
97	Circadian rhythm_Homo sapiens_hsa04710	0.36020336
98	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.34218106
99	Mineral absorption_Homo sapiens_hsa04978	0.31844700
100	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.31581300

ICE2P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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