ICE2P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H4-K12 acetylation (GO:0043983)8.61800956
2phosphorelay signal transduction system (GO:0000160)7.97314313
3regulation of short-term neuronal synaptic plasticity (GO:0048172)7.10311778
4flavonoid metabolic process (GO:0009812)5.93502173
5ionotropic glutamate receptor signaling pathway (GO:0035235)5.82485470
6heparin metabolic process (GO:0030202)5.68521116
7heparin biosynthetic process (GO:0030210)5.68521116
8piRNA metabolic process (GO:0034587)5.67718996
9neuronal action potential (GO:0019228)5.66055475
10myoblast fusion (GO:0007520)5.47420006
11neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)5.41271847
12serotonin metabolic process (GO:0042428)5.28374899
13endoderm formation (GO:0001706)5.27998535
14primary amino compound metabolic process (GO:1901160)5.13716421
15lymph node development (GO:0048535)4.92418774
16peripheral nervous system development (GO:0007422)4.90803162
17phenylpropanoid metabolic process (GO:0009698)4.89841486
18syncytium formation by plasma membrane fusion (GO:0000768)4.68468558
19negative regulation of calcium ion transport into cytosol (GO:0010523)4.62110275
20cellular response to ATP (GO:0071318)4.61034867
21negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)4.54477331
22positive regulation of heat generation (GO:0031652)4.44418041
23regulation of type B pancreatic cell apoptotic process (GO:2000674)4.39286826
24positive regulation of icosanoid secretion (GO:0032305)4.22924486
25behavioral response to nicotine (GO:0035095)4.21256880
26positive regulation of fatty acid transport (GO:2000193)4.20980478
27phenol-containing compound catabolic process (GO:0019336)4.19423284
28regulation of fever generation (GO:0031620)4.17775777
29regulation of female gonad development (GO:2000194)4.05697714
30replicative senescence (GO:0090399)4.04547623
31protein localization to synapse (GO:0035418)3.99402935
32negative regulation of sodium ion transport (GO:0010766)3.96148875
33regulation of cell maturation (GO:1903429)3.90711397
34regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.84946420
35syncytium formation (GO:0006949)3.81984527
36positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.79815197
37regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.79815197
38regulation of feeding behavior (GO:0060259)3.79639179
39positive regulation of gastrulation (GO:2000543)3.79612833
40synaptic transmission, glutamatergic (GO:0035249)3.76048633
41negative regulation of cytosolic calcium ion concentration (GO:0051481)3.75840868
42dopaminergic neuron differentiation (GO:0071542)3.69889373
43detection of mechanical stimulus involved in sensory perception (GO:0050974)3.69825066
44regulation of glutamate receptor signaling pathway (GO:1900449)3.66183711
45regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.58447944
46positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.58447944
47indole-containing compound metabolic process (GO:0042430)3.54270232
48appendage development (GO:0048736)3.54194061
49limb development (GO:0060173)3.54194061
50membrane depolarization during action potential (GO:0086010)3.51614185
51tachykinin receptor signaling pathway (GO:0007217)3.49190956
52alanine transport (GO:0032328)3.48019834
53glutamate receptor signaling pathway (GO:0007215)3.47184719
54regulation of heat generation (GO:0031650)3.43425615
55sulfation (GO:0051923)3.42439020
56primitive streak formation (GO:0090009)3.40761636
57cardiovascular system development (GO:0072358)3.36583042
58histone H4-K8 acetylation (GO:0043982)3.33482986
59histone H4-K5 acetylation (GO:0043981)3.33482986
60regulation of neuron projection regeneration (GO:0070570)3.30733578
61regulation of axon regeneration (GO:0048679)3.30733578
62hydrogen peroxide biosynthetic process (GO:0050665)3.27628232
63regulation of non-canonical Wnt signaling pathway (GO:2000050)3.25352860
64regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.20659813
65regulation of catecholamine metabolic process (GO:0042069)3.15245213
66regulation of dopamine metabolic process (GO:0042053)3.15245213
67regulation of establishment of cell polarity (GO:2000114)3.13013444
68regulation of icosanoid secretion (GO:0032303)3.12922859
69cytoplasmic mRNA processing body assembly (GO:0033962)3.10580364
70prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.09793128
71action potential (GO:0001508)3.09383675
72histone H4-K16 acetylation (GO:0043984)3.02908415
73positive regulation of prostaglandin secretion (GO:0032308)2.99685654
74transmission of nerve impulse (GO:0019226)2.92650171
75gene silencing by RNA (GO:0031047)2.91873002
76reactive oxygen species biosynthetic process (GO:1903409)2.91247030
77regulation of establishment or maintenance of cell polarity (GO:0032878)2.89856062
78calcium ion-dependent exocytosis (GO:0017156)2.89306047
79protein K48-linked deubiquitination (GO:0071108)2.87887216
80neuron cell-cell adhesion (GO:0007158)2.86897606
81pyrimidine dimer repair (GO:0006290)2.85284326
82behavioral response to ethanol (GO:0048149)2.82634176
83regulation of B cell receptor signaling pathway (GO:0050855)2.82405427
84positive regulation of axon extension (GO:0045773)2.82054713
85indole-containing compound catabolic process (GO:0042436)2.81218928
86indolalkylamine catabolic process (GO:0046218)2.81218928
87tryptophan catabolic process (GO:0006569)2.81218928
88positive regulation of mRNA catabolic process (GO:0061014)2.80961056
89cilium or flagellum-dependent cell motility (GO:0001539)2.79468411
90organelle disassembly (GO:1903008)2.78488974
91interferon-gamma secretion (GO:0072643)2.76211531
92locomotory exploration behavior (GO:0035641)2.75504007
93positive regulation of potassium ion transmembrane transport (GO:1901381)2.74806539
94branching involved in prostate gland morphogenesis (GO:0060442)2.74429393
95negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.73576227
96positive regulation of uterine smooth muscle contraction (GO:0070474)2.73520739
97endocardial cushion development (GO:0003197)2.72896579
98response to acidic pH (GO:0010447)2.72586265
99positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)2.71497155
100autophagic vacuole fusion (GO:0000046)2.69363701

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.76362222
2RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.30012724
3ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.96665374
4GBX2_23144817_ChIP-Seq_PC3_Human3.53342451
5VDR_22108803_ChIP-Seq_LS180_Human3.47139552
6ZFP57_27257070_Chip-Seq_ESCs_Mouse3.04086327
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.66958861
8EWS_26573619_Chip-Seq_HEK293_Human2.57625032
9PIAS1_25552417_ChIP-Seq_VCAP_Human2.43527382
10FUS_26573619_Chip-Seq_HEK293_Human2.32099265
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.30549243
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.21544654
13IGF1R_20145208_ChIP-Seq_DFB_Human2.05284201
14ZNF274_21170338_ChIP-Seq_K562_Hela1.94590314
15PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.87227087
16CTBP1_25329375_ChIP-Seq_LNCAP_Human1.84822726
17SMAD3_21741376_ChIP-Seq_EPCs_Human1.84610771
18SMAD4_21799915_ChIP-Seq_A2780_Human1.77778740
19SALL1_21062744_ChIP-ChIP_HESCs_Human1.74458228
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71902504
21P300_19829295_ChIP-Seq_ESCs_Human1.70614207
22TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.70074842
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.70070515
24NR3C1_21868756_ChIP-Seq_MCF10A_Human1.68384389
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.68102060
26STAT3_23295773_ChIP-Seq_U87_Human1.67163268
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.66703087
28POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.66450194
29TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66450194
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.66139402
31SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.66060990
32TAF15_26573619_Chip-Seq_HEK293_Human1.59309119
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.52408446
34ER_23166858_ChIP-Seq_MCF-7_Human1.52208900
35RBPJ_22232070_ChIP-Seq_NCS_Mouse1.50977764
36SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.49528833
37AR_21572438_ChIP-Seq_LNCaP_Human1.48938935
38SMAD4_21741376_ChIP-Seq_EPCs_Human1.43285000
39SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.42729146
40LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41169090
41PRDM14_20953172_ChIP-Seq_ESCs_Human1.41158253
42OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41129591
43REST_21632747_ChIP-Seq_MESCs_Mouse1.38756297
44EZH2_27304074_Chip-Seq_ESCs_Mouse1.38185805
45TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37839873
46TCF4_23295773_ChIP-Seq_U87_Human1.37015649
47RUNX2_22187159_ChIP-Seq_PCA_Human1.36690288
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.36331549
49FOXA1_25329375_ChIP-Seq_VCAP_Human1.34111864
50FOXA1_27270436_Chip-Seq_PROSTATE_Human1.34111864
51EED_16625203_ChIP-ChIP_MESCs_Mouse1.34047193
52EZH2_27294783_Chip-Seq_ESCs_Mouse1.33171867
53SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32962044
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.32085126
55YAP1_20516196_ChIP-Seq_MESCs_Mouse1.29824026
56HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.29148914
57DROSHA_22980978_ChIP-Seq_HELA_Human1.28325788
58TCF4_22108803_ChIP-Seq_LS180_Human1.26387437
59ETV2_25802403_ChIP-Seq_MESCs_Mouse1.24848832
60TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21803854
61IKZF1_21737484_ChIP-ChIP_HCT116_Human1.21608432
62AR_25329375_ChIP-Seq_VCAP_Human1.21046052
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20385915
64RNF2_27304074_Chip-Seq_NSC_Mouse1.19404489
65FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.18720599
66TAL1_26923725_Chip-Seq_HPCs_Mouse1.17960699
67SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.17321217
68PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16893819
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12979738
70OCT1_27270436_Chip-Seq_PROSTATE_Human1.12541017
71BCAT_22108803_ChIP-Seq_LS180_Human1.12069690
72FLI1_21867929_ChIP-Seq_TH2_Mouse1.11842472
73NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.11166443
74NANOG_18555785_Chip-Seq_ESCs_Mouse1.10879343
75RNF2_27304074_Chip-Seq_ESCs_Mouse1.10541532
76SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.10232517
77ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09766750
78STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.09510862
79REST_18959480_ChIP-ChIP_MESCs_Mouse1.08712552
80BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08070477
81SMAD3_21741376_ChIP-Seq_HESCs_Human1.06628853
82RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.03584445
83SUZ12_27294783_Chip-Seq_ESCs_Mouse1.02944723
84CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02204967
85GF1B_26923725_Chip-Seq_HPCs_Mouse1.00938008
86MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00562764
87FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00211180
88IRF1_19129219_ChIP-ChIP_H3396_Human0.99155360
89EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99145462
90TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97497457
91KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.96460736
92SMAD4_21741376_ChIP-Seq_HESCs_Human0.95948608
93IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.95871259
94JARID2_20064375_ChIP-Seq_MESCs_Mouse0.95610561
95MYC_18940864_ChIP-ChIP_HL60_Human0.95035567
96TBX3_20139965_ChIP-Seq_ESCs_Mouse0.94871660
97TBX3_20139965_ChIP-Seq_MESCs_Mouse0.93627055
98BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93564406
99NFE2_27457419_Chip-Seq_LIVER_Mouse0.93017707
100WDR5_24793694_ChIP-Seq_LNCAP_Human0.91313282

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001968_abnormal_touch/_nociception3.94065207
2MP0009046_muscle_twitch3.85697862
3MP0004270_analgesia3.64521248
4MP0003880_abnormal_central_pattern3.31774318
5MP0002277_abnormal_respiratory_mucosa3.20087386
6MP0005423_abnormal_somatic_nervous3.17655372
7MP0002822_catalepsy2.96449182
8MP0003890_abnormal_embryonic-extraembry2.76486609
9MP0009745_abnormal_behavioral_response2.70852958
10MP0002064_seizures2.65289632
11MP0001486_abnormal_startle_reflex2.55478615
12MP0002733_abnormal_thermal_nociception2.52987093
13MP0005646_abnormal_pituitary_gland2.49744594
14MP0002734_abnormal_mechanical_nocicepti2.33768036
15MP0003635_abnormal_synaptic_transmissio2.29534177
16MP0008877_abnormal_DNA_methylation2.26833086
17MP0002736_abnormal_nociception_after2.16862709
18MP0008961_abnormal_basal_metabolism2.09423377
19MP0002735_abnormal_chemical_nociception1.95523737
20MP0010352_gastrointestinal_tract_polyps1.89852219
21MP0004133_heterotaxia1.87641141
22MP0002089_abnormal_postnatal_growth/wei1.86878230
23MP0002751_abnormal_autonomic_nervous1.84573308
24MP0002138_abnormal_hepatobiliary_system1.79392245
25MP0003195_calcinosis1.77898557
26MP0008872_abnormal_physiological_respon1.73695750
27MP0000750_abnormal_muscle_regeneration1.73621795
28MP0001346_abnormal_lacrimal_gland1.70705182
29MP0002572_abnormal_emotion/affect_behav1.67701262
30MP0002272_abnormal_nervous_system1.66632812
31MP0001485_abnormal_pinna_reflex1.64853256
32MP0001970_abnormal_pain_threshold1.58983020
33MP0005248_abnormal_Harderian_gland1.56958751
34MP0010030_abnormal_orbit_morphology1.55943356
35MP0000751_myopathy1.54926856
36MP0002090_abnormal_vision1.53353885
37MP0003646_muscle_fatigue1.49727585
38MP0005386_behavior/neurological_phenoty1.48857282
39MP0004924_abnormal_behavior1.48857282
40MP0004145_abnormal_muscle_electrophysio1.48113009
41MP0004043_abnormal_pH_regulation1.47739771
42MP0003045_fibrosis1.45289538
43MP0003633_abnormal_nervous_system1.44131341
44MP0002067_abnormal_sensory_capabilities1.43565305
45MP0000427_abnormal_hair_cycle1.39485663
46MP0001986_abnormal_taste_sensitivity1.38304257
47MP0001879_abnormal_lymphatic_vessel1.33188438
48MP0003119_abnormal_digestive_system1.28252345
49MP0000749_muscle_degeneration1.26991567
50MP0005551_abnormal_eye_electrophysiolog1.25523108
51MP0002638_abnormal_pupillary_reflex1.24980168
52MP0003631_nervous_system_phenotype1.18741075
53MP0005671_abnormal_response_to1.11933034
54MP0002063_abnormal_learning/memory/cond1.11805469
55MP0002234_abnormal_pharynx_morphology1.07029852
56MP0002148_abnormal_hypersensitivity_rea1.06230209
57MP0004742_abnormal_vestibular_system1.04556365
58MP0004142_abnormal_muscle_tone1.02982905
59MP0005084_abnormal_gallbladder_morpholo1.01712993
60MP0002184_abnormal_innervation0.99849397
61MP0003385_abnormal_body_wall0.99283701
62MP0001293_anophthalmia0.96468647
63MP0001188_hyperpigmentation0.93760898
64MP0008775_abnormal_heart_ventricle0.92944079
65MP0002693_abnormal_pancreas_physiology0.92631974
66MP0001664_abnormal_digestion0.88792285
67MP0003718_maternal_effect0.87267138
68MP0004134_abnormal_chest_morphology0.83477062
69MP0005645_abnormal_hypothalamus_physiol0.82931763
70MP0003283_abnormal_digestive_organ0.81675598
71MP0003303_peritoneal_inflammation0.81482950
72MP0005332_abnormal_amino_acid0.80692102
73MP0000428_abnormal_craniofacial_morphol0.79228400
74MP0001501_abnormal_sleep_pattern0.79013907
75MP0003959_abnormal_lean_body0.78657411
76MP0001324_abnormal_eye_pigmentation0.78315524
77MP0006292_abnormal_olfactory_placode0.77825539
78MP0001440_abnormal_grooming_behavior0.73597267
79MP0002069_abnormal_eating/drinking_beha0.72428456
80MP0005171_absent_coat_pigmentation0.71978547
81MP0006276_abnormal_autonomic_nervous0.65170443
82MP0001663_abnormal_digestive_system0.65080966
83MP0000631_abnormal_neuroendocrine_gland0.64888297
84MP0000230_abnormal_systemic_arterial0.64720278
85MP0000613_abnormal_salivary_gland0.64469258
86MP0002837_dystrophic_cardiac_calcinosis0.64459347
87MP0005195_abnormal_posterior_eye0.63873677
88MP0002557_abnormal_social/conspecific_i0.63052454
89MP0002882_abnormal_neuron_morphology0.61755972
90MP0008875_abnormal_xenobiotic_pharmacok0.61725387
91MP0000778_abnormal_nervous_system0.60464514
92MP0005075_abnormal_melanosome_morpholog0.60160848
93MP0005448_abnormal_energy_balance0.59780874
94MP0000955_abnormal_spinal_cord0.59686151
95MP0010386_abnormal_urinary_bladder0.57947883
96MP0003698_abnormal_male_reproductive0.57859889
97MP0002066_abnormal_motor_capabilities/c0.57315224
98MP0003632_abnormal_nervous_system0.56697239
99MP0003011_delayed_dark_adaptation0.55491896
100MP0003137_abnormal_impulse_conducting0.54023535

Predicted human phenotypes

RankGene SetZ-score
1Slender build (HP:0001533)7.05708542
2Inability to walk (HP:0002540)4.52051962
3Prominent supraorbital ridges (HP:0000336)4.50954849
4Increased number of teeth (HP:0011069)4.50358017
5Type II lissencephaly (HP:0007260)4.48580524
6Anhidrosis (HP:0000970)4.38090676
7Progressive inability to walk (HP:0002505)3.80382662
8Stomach cancer (HP:0012126)3.73633998
9Hypoplastic ischia (HP:0003175)3.71838871
10Autoamputation (HP:0001218)3.69821014
11Midline defect of the nose (HP:0004122)3.66441233
12Focal motor seizures (HP:0011153)3.66264495
13Medial flaring of the eyebrow (HP:0010747)3.53640549
14Curly hair (HP:0002212)3.53304293
15Gaze-evoked nystagmus (HP:0000640)3.47540310
16Amblyopia (HP:0000646)3.31039499
17Hyperventilation (HP:0002883)3.21279930
18Ventricular fibrillation (HP:0001663)3.11169233
19Abnormality of the ischium (HP:0003174)3.10855663
20Thick nail (HP:0001805)3.09783657
21Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.07923648
22Mesangial abnormality (HP:0001966)3.04415891
23Osteomalacia (HP:0002749)2.98833778
24Nephrogenic diabetes insipidus (HP:0009806)2.97413939
25Anterior segment dysgenesis (HP:0007700)2.95985693
26Fair hair (HP:0002286)2.87191996
27Abnormality of secondary sexual hair (HP:0009888)2.84454900
28Abnormality of the axillary hair (HP:0100134)2.84454900
29Optic nerve hypoplasia (HP:0000609)2.80366265
30Gait imbalance (HP:0002141)2.79266877
31Relative macrocephaly (HP:0004482)2.76395214
32Congenital, generalized hypertrichosis (HP:0004540)2.74212941
33Pancreatic cysts (HP:0001737)2.73176392
34Cerebellar dysplasia (HP:0007033)2.70687342
35Abnormality of the sella turcica (HP:0002679)2.70052765
36Partial agenesis of the corpus callosum (HP:0001338)2.68614556
37Lissencephaly (HP:0001339)2.66074853
38Neoplasm of the adrenal cortex (HP:0100641)2.63594505
39Cystic hygroma (HP:0000476)2.62118374
40Neuroendocrine neoplasm (HP:0100634)2.61517063
41Alveolar cell carcinoma (HP:0006519)2.60458691
42Pheochromocytoma (HP:0002666)2.60335075
43Congenital primary aphakia (HP:0007707)2.58834347
44Tapered finger (HP:0001182)2.58781929
45True hermaphroditism (HP:0010459)2.53474920
46Broad metatarsal (HP:0001783)2.51893012
47Protruding tongue (HP:0010808)2.51127416
48Pancreatic fibrosis (HP:0100732)2.50172833
49Long nose (HP:0003189)2.50163124
50Clumsiness (HP:0002312)2.48286767
51Glossoptosis (HP:0000162)2.45755038
52Retinal dysplasia (HP:0007973)2.45177554
53Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.41278360
54Abnormality of alanine metabolism (HP:0010916)2.39564427
55Hyperalaninemia (HP:0003348)2.39564427
56Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.39564427
57Megalencephaly (HP:0001355)2.39560744
58Nephronophthisis (HP:0000090)2.39417094
59Furrowed tongue (HP:0000221)2.36104432
60Hydroxyprolinuria (HP:0003080)2.35523345
61Abnormality of proline metabolism (HP:0010907)2.35523345
62Tubular atrophy (HP:0000092)2.32780363
63Poor coordination (HP:0002370)2.30778034
64Brachycephaly (HP:0000248)2.29993300
65Neoplasm of the tracheobronchial system (HP:0100552)2.29672542
66Dynein arm defect of respiratory motile cilia (HP:0012255)2.29240794
67Absent/shortened dynein arms (HP:0200106)2.29240794
68Genetic anticipation (HP:0003743)2.24718734
69Epileptic encephalopathy (HP:0200134)2.21778178
70Sclerocornea (HP:0000647)2.21000453
71Meningioma (HP:0002858)2.18839689
72Generalized hypopigmentation of hair (HP:0011358)2.18237590
73Aplasia/Hypoplasia of the tibia (HP:0005772)2.17921779
74High anterior hairline (HP:0009890)2.17361043
75Overgrowth (HP:0001548)2.16420835
76Vaginal atresia (HP:0000148)2.15186496
77Hip contracture (HP:0003273)2.14016613
78Genital tract atresia (HP:0001827)2.13048964
79Self-mutilation (HP:0000742)2.12948504
80Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.11455428
81Neonatal respiratory distress (HP:0002643)2.10143040
82Irregular vertebral endplates (HP:0003301)2.07178219
83Autism (HP:0000717)2.06697854
84Intellectual disability, profound (HP:0002187)2.05626212
85Bone cyst (HP:0012062)2.03696718
86Deeply set eye (HP:0000490)2.02395931
87Episodic fever (HP:0001954)1.98051227
88Hamartoma of the eye (HP:0010568)1.95868906
89Poor eye contact (HP:0000817)1.93750185
90Chronic bronchitis (HP:0004469)1.90078140
91Abnormal auditory evoked potentials (HP:0006958)1.88884226
92Meningocele (HP:0002435)1.88503192
93Melanocytic nevus (HP:0000995)1.87610894
94Preaxial foot polydactyly (HP:0001841)1.85118667
95Absent hair (HP:0002298)1.84138095
96Focal seizures (HP:0007359)1.83841373
97Colon cancer (HP:0003003)1.83650102
98Generalized tonic-clonic seizures (HP:0002069)1.81400814
99Abnormal respiratory motile cilium physiology (HP:0012261)1.81345073
100Drooling (HP:0002307)1.80335407

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK246.24561099
2FRK4.44496776
3STK33.14022957
4PNCK3.10058864
5TAOK32.91510357
6ZAK2.83838004
7IRAK12.78694402
8MAPKAPK32.72537261
9ACVR1B2.18466899
10NUAK11.94253820
11ADRBK11.88300730
12BMPR1B1.86027099
13ADRBK21.85039198
14MAPK131.69858639
15SIK11.61734518
16CDK191.58970077
17MAP3K131.55518703
18MAP3K41.55114238
19MAP2K71.52441232
20CHUK1.51609843
21IRAK21.50070270
22PINK11.48498397
23EEF2K1.45722725
24FGFR21.38576375
25TXK1.33872638
26NTRK11.32180706
27VRK21.26925626
28TEC1.22796552
29CSNK1G11.22185212
30CCNB11.19690746
31CSNK1G21.14210783
32SGK21.13986631
33TAF11.11366465
34GRK11.10881017
35MAP4K21.07875115
36MATK1.07679921
37DYRK1A1.06010276
38PASK1.03531683
39MAPKAPK50.99915356
40TSSK60.99772563
41INSRR0.99564687
42PRKCG0.99442306
43TRPM70.97731169
44CDK30.92779407
45DYRK20.90389572
46MARK10.89742462
47TGFBR10.86400101
48IKBKB0.85650063
49WNK30.79899342
50CSNK1G30.78022610
51ERBB30.76090120
52VRK10.74756233
53MAP2K40.72845637
54PLK10.71855964
55DAPK10.70140857
56PTK2B0.69424618
57ERBB20.69271461
58CAMK2B0.68786561
59SGK2230.65654536
60SGK4940.65654536
61GRK50.64041980
62ITK0.62370666
63DYRK30.61467266
64IRAK40.60680428
65WNK40.55777028
66PRKCQ0.55535569
67PRKAA20.55309260
68CSF1R0.54519910
69MELK0.54102040
70STK110.53299966
71CAMK1G0.52454214
72SIK20.51087250
73PRKAA10.50525367
74TIE10.50013109
75PAK30.45352128
76CAMK2A0.45194542
77CHEK20.44676695
78PRKCE0.43743087
79PBK0.43630938
80RPS6KA60.42338829
81SGK30.41808097
82PHKG10.40964443
83PHKG20.40964443
84TYRO30.38936245
85EIF2AK20.38490640
86RPS6KA50.38488798
87CDC70.37542984
88PRKACG0.35681497
89OBSCN0.34882530
90CSNK1D0.33846254
91STK38L0.33821736
92NTRK20.29710405
93PLK30.29291705
94PKN10.29079023
95GRK60.28849442
96AKT20.28405259
97RPS6KA20.28157585
98PRKACA0.28095371
99CDK80.27988061
100EPHB20.27951571

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.42793164
2Long-term depression_Homo sapiens_hsa047303.21130824
3Asthma_Homo sapiens_hsa053103.11875194
4Glutamatergic synapse_Homo sapiens_hsa047242.49035475
5Circadian entrainment_Homo sapiens_hsa047132.48282858
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.43399331
7Dorso-ventral axis formation_Homo sapiens_hsa043202.27801525
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.21267134
9Amphetamine addiction_Homo sapiens_hsa050312.04735176
10Dopaminergic synapse_Homo sapiens_hsa047281.91369164
11Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.89693193
12Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.87429267
13Taste transduction_Homo sapiens_hsa047421.85550641
14Olfactory transduction_Homo sapiens_hsa047401.83649387
15Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.77147628
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.76158704
17Graft-versus-host disease_Homo sapiens_hsa053321.70578931
18Tryptophan metabolism_Homo sapiens_hsa003801.62732556
19Allograft rejection_Homo sapiens_hsa053301.59902989
20Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.58704981
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.55742195
22Autoimmune thyroid disease_Homo sapiens_hsa053201.53288512
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.48396371
24Type I diabetes mellitus_Homo sapiens_hsa049401.46712385
25Linoleic acid metabolism_Homo sapiens_hsa005911.43727499
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.39788532
27Chemical carcinogenesis_Homo sapiens_hsa052041.38359668
28Selenocompound metabolism_Homo sapiens_hsa004501.36440337
29Pentose and glucuronate interconversions_Homo sapiens_hsa000401.34694357
30Nitrogen metabolism_Homo sapiens_hsa009101.34491807
31Starch and sucrose metabolism_Homo sapiens_hsa005001.30025399
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.29041836
33Caffeine metabolism_Homo sapiens_hsa002321.28929264
34Oxytocin signaling pathway_Homo sapiens_hsa049211.27971238
35Salivary secretion_Homo sapiens_hsa049701.26479585
36Serotonergic synapse_Homo sapiens_hsa047261.26199474
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.18578548
38Sphingolipid metabolism_Homo sapiens_hsa006001.17073841
39Cholinergic synapse_Homo sapiens_hsa047251.16940553
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.16064716
41African trypanosomiasis_Homo sapiens_hsa051431.13073879
42Gastric acid secretion_Homo sapiens_hsa049711.10148075
43Calcium signaling pathway_Homo sapiens_hsa040201.08934334
44Carbohydrate digestion and absorption_Homo sapiens_hsa049731.08526886
45Retinol metabolism_Homo sapiens_hsa008301.08481149
46Morphine addiction_Homo sapiens_hsa050321.07398927
47Sphingolipid signaling pathway_Homo sapiens_hsa040711.07187009
48Renin secretion_Homo sapiens_hsa049241.07075430
49Cardiac muscle contraction_Homo sapiens_hsa042601.05770920
50Staphylococcus aureus infection_Homo sapiens_hsa051501.00308249
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.98319212
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.97414975
53Rheumatoid arthritis_Homo sapiens_hsa053230.95840120
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.93774644
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.93325082
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.91674314
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90573017
58Histidine metabolism_Homo sapiens_hsa003400.87717776
59RNA polymerase_Homo sapiens_hsa030200.86471360
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86151161
61Phenylalanine metabolism_Homo sapiens_hsa003600.84979797
62MAPK signaling pathway_Homo sapiens_hsa040100.83764190
63Ether lipid metabolism_Homo sapiens_hsa005650.82752844
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.78220010
65Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.73778970
66ABC transporters_Homo sapiens_hsa020100.73174228
67GABAergic synapse_Homo sapiens_hsa047270.69368036
68Fanconi anemia pathway_Homo sapiens_hsa034600.63235908
69Cocaine addiction_Homo sapiens_hsa050300.62738751
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59979274
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.57742968
72Vitamin B6 metabolism_Homo sapiens_hsa007500.56752615
73Rap1 signaling pathway_Homo sapiens_hsa040150.54819077
74Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52031406
75Insulin secretion_Homo sapiens_hsa049110.51466116
76Long-term potentiation_Homo sapiens_hsa047200.46906777
77Systemic lupus erythematosus_Homo sapiens_hsa053220.43667891
78Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.41619880
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.39844774
80Alzheimers disease_Homo sapiens_hsa050100.39721136
81Ras signaling pathway_Homo sapiens_hsa040140.39373823
82Phototransduction_Homo sapiens_hsa047440.38699040
83Viral myocarditis_Homo sapiens_hsa054160.37619002
84Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.37571632
85Butanoate metabolism_Homo sapiens_hsa006500.36622982
86cAMP signaling pathway_Homo sapiens_hsa040240.36206208
87Ovarian steroidogenesis_Homo sapiens_hsa049130.35934995
88Tyrosine metabolism_Homo sapiens_hsa003500.35869915
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32426370
90Melanoma_Homo sapiens_hsa052180.31385875
91Antigen processing and presentation_Homo sapiens_hsa046120.30681023
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.30516859
93Hippo signaling pathway_Homo sapiens_hsa043900.30207748
94T cell receptor signaling pathway_Homo sapiens_hsa046600.29504547
95Type II diabetes mellitus_Homo sapiens_hsa049300.29374761
96Sulfur metabolism_Homo sapiens_hsa009200.28332517
97Estrogen signaling pathway_Homo sapiens_hsa049150.27196843
98Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.26294824
99Pancreatic secretion_Homo sapiens_hsa049720.25059497
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.25026273

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