ICK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. This gene encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. The protein localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. Alternative splicing has been observed at this locus and two variants, encoding the same isoform, have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)8.35729493
2central nervous system myelination (GO:0022010)8.35729493
3ensheathment of neurons (GO:0007272)6.26862809
4axon ensheathment (GO:0008366)6.26862809
5myelination (GO:0042552)6.22515460
6eye photoreceptor cell differentiation (GO:0001754)5.87263503
7photoreceptor cell differentiation (GO:0046530)5.87263503
8fatty acid elongation (GO:0030497)5.69375840
9presynaptic membrane assembly (GO:0097105)4.84353168
10negative regulation of neurotransmitter secretion (GO:0046929)4.71560367
11oligodendrocyte differentiation (GO:0048709)4.62584615
12glycerophospholipid catabolic process (GO:0046475)4.58309305
13presynaptic membrane organization (GO:0097090)4.40973788
14myelination in peripheral nervous system (GO:0022011)4.24179299
15peripheral nervous system axon ensheathment (GO:0032292)4.24179299
16asymmetric protein localization (GO:0008105)4.08970252
17virion attachment to host cell (GO:0019062)4.07779946
18adhesion of symbiont to host cell (GO:0044650)4.07779946
19long-chain fatty acid biosynthetic process (GO:0042759)3.93525588
20lateral sprouting from an epithelium (GO:0060601)3.91441881
21astrocyte development (GO:0014002)3.91428508
22apical protein localization (GO:0045176)3.87178304
23myelin maintenance (GO:0043217)3.79904049
24cholesterol biosynthetic process (GO:0006695)3.77606653
25cerebral cortex radially oriented cell migration (GO:0021799)3.75914378
26limb bud formation (GO:0060174)3.71506812
27negative regulation of axon guidance (GO:1902668)3.70619165
28peptidyl-tyrosine autophosphorylation (GO:0038083)3.69688861
29neuron cell-cell adhesion (GO:0007158)3.68411254
30negative regulation of neurotransmitter transport (GO:0051589)3.65270971
31negative regulation of axon extension (GO:0030517)3.51626525
32negative regulation of axonogenesis (GO:0050771)3.48448463
33negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.41791662
34glucocorticoid biosynthetic process (GO:0006704)3.41430253
35positive regulation of oligodendrocyte differentiation (GO:0048714)3.29737134
36response to hepatocyte growth factor (GO:0035728)3.27750998
37cellular response to hepatocyte growth factor stimulus (GO:0035729)3.27750998
38regulation of somitogenesis (GO:0014807)3.22803722
39negative regulation of myoblast differentiation (GO:0045662)3.19079064
40establishment of mitochondrion localization (GO:0051654)3.18248643
41regulation of collateral sprouting (GO:0048670)3.17548516
42substantia nigra development (GO:0021762)3.17265298
43adhesion of symbiont to host (GO:0044406)3.17088997
44sterol biosynthetic process (GO:0016126)3.16848079
45negative regulation of protein localization to cell surface (GO:2000009)3.12970135
46regulation of axon guidance (GO:1902667)3.08753819
47cytoplasmic mRNA processing body assembly (GO:0033962)3.08598626
48transmission of nerve impulse (GO:0019226)3.07265375
49creatine metabolic process (GO:0006600)3.05581275
50cellular response to epinephrine stimulus (GO:0071872)3.00406773
51estrogen biosynthetic process (GO:0006703)2.99994708
52startle response (GO:0001964)2.99989620
53regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.96716694
54dendrite morphogenesis (GO:0048813)2.96579197
55calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.95260703
56membrane assembly (GO:0071709)2.95088194
57response to redox state (GO:0051775)2.94858248
58response to follicle-stimulating hormone (GO:0032354)2.94720730
59positive regulation of action potential (GO:0045760)2.94357760
60negative regulation of axon extension involved in axon guidance (GO:0048843)2.91954909
61cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.88142005
62axonal fasciculation (GO:0007413)2.86818495
63enteric nervous system development (GO:0048484)2.86600593
64isoprenoid biosynthetic process (GO:0008299)2.85130726
65response to epinephrine (GO:0071871)2.84668659
66long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.82612953
67neuronal ion channel clustering (GO:0045161)2.79886747
68magnesium ion transport (GO:0015693)2.77559236
69cerebellar granule cell differentiation (GO:0021707)2.76093860
70glial cell differentiation (GO:0010001)2.73701050
71organ growth (GO:0035265)2.73657780
72Leydig cell differentiation (GO:0033327)2.73555835
73cellular response to monoamine stimulus (GO:0071868)2.71799761
74cellular response to catecholamine stimulus (GO:0071870)2.71799761
75phosphatidylinositol 3-kinase signaling (GO:0014065)2.71465468
76positive regulation of pseudopodium assembly (GO:0031274)2.70449013
77establishment of nucleus localization (GO:0040023)2.70229156
78semaphorin-plexin signaling pathway (GO:0071526)2.70028631
79iron ion import (GO:0097286)2.69526973
80peripheral nervous system development (GO:0007422)2.69291351
81ganglion development (GO:0061548)2.68608520
82mating behavior (GO:0007617)2.68578759
83somite development (GO:0061053)2.68058940
84postsynaptic membrane organization (GO:0001941)2.66986201
85L-amino acid import (GO:0043092)2.65523182
86glomerular filtration (GO:0003094)2.64537788
87pyrimidine nucleobase catabolic process (GO:0006208)2.64410658
88protein palmitoylation (GO:0018345)2.63889097
89negative regulation of JUN kinase activity (GO:0043508)2.62911526
90suckling behavior (GO:0001967)2.60774324
91nucleotide transmembrane transport (GO:1901679)2.57659711
92nucleobase catabolic process (GO:0046113)2.57655203
93adult walking behavior (GO:0007628)2.55980475
94response to monoamine (GO:0071867)2.55848409
95response to catecholamine (GO:0071869)2.55848409
96regulation of axon extension involved in axon guidance (GO:0048841)2.53306552
97protein localization to synapse (GO:0035418)2.52343493
98androgen biosynthetic process (GO:0006702)2.52246016
99neuron recognition (GO:0008038)2.51914968
100bone trabecula formation (GO:0060346)2.50056529
101positive regulation of neurological system process (GO:0031646)2.48902990
102negative regulation of astrocyte differentiation (GO:0048712)2.47639966
103axon development (GO:0061564)2.47260468
104cell migration in hindbrain (GO:0021535)2.45799517
105neuromuscular junction development (GO:0007528)2.45380250
106fatty-acyl-CoA biosynthetic process (GO:0046949)2.43993950
107embryonic retina morphogenesis in camera-type eye (GO:0060059)2.42922579
108glial cell development (GO:0021782)2.42328659
109positive regulation of actin filament depolymerization (GO:0030836)2.42135814
110prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.42091605
111nerve growth factor signaling pathway (GO:0038180)2.41721962
112dendritic spine morphogenesis (GO:0060997)2.41038750
113vesicle transport along microtubule (GO:0047496)2.40490772
114glucocorticoid metabolic process (GO:0008211)2.40265259
115activated T cell proliferation (GO:0050798)2.40238993
116establishment of planar polarity (GO:0001736)2.40222304
117establishment of tissue polarity (GO:0007164)2.40222304
118insulin-like growth factor receptor signaling pathway (GO:0048009)2.40073947
119regulation of oligodendrocyte differentiation (GO:0048713)2.39215118
120neuron remodeling (GO:0016322)2.38535851
121regulation of myelination (GO:0031641)2.38206410
122cyclic nucleotide catabolic process (GO:0009214)2.38043968
123negative regulation of cytosolic calcium ion concentration (GO:0051481)2.34650810
124synapse assembly (GO:0007416)2.34292942
125hippo signaling (GO:0035329)2.33861718
126desmosome organization (GO:0002934)2.33316328
127axon extension (GO:0048675)2.32320907
128retinal ganglion cell axon guidance (GO:0031290)2.31393791
129epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.30916695
130macroautophagy (GO:0016236)2.29080166
131intestinal epithelial cell development (GO:0060576)2.27751205
132regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.26965135
133regulation of clathrin-mediated endocytosis (GO:2000369)2.23352229
134positive regulation of dendritic spine morphogenesis (GO:0061003)2.23206999
135neuron projection extension involved in neuron projection guidance (GO:1902284)2.22468310
136axon extension involved in axon guidance (GO:0048846)2.22468310
137vocalization behavior (GO:0071625)2.21690893
138import into cell (GO:0098657)2.21348030
139cilium or flagellum-dependent cell motility (GO:0001539)2.21124736
140cellular response to antibiotic (GO:0071236)2.20453649
141cerebral cortex cell migration (GO:0021795)2.19766420
142chondrocyte development (GO:0002063)2.19747584
143NLS-bearing protein import into nucleus (GO:0006607)2.19075693
144substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.18797872
145substrate-independent telencephalic tangential migration (GO:0021826)2.18797872
146negative regulation of keratinocyte proliferation (GO:0010839)2.18662563
147negative regulation of glycogen biosynthetic process (GO:0045719)2.14246001
148branching involved in prostate gland morphogenesis (GO:0060442)2.13497903
149axonemal dynein complex assembly (GO:0070286)2.13223756
150paraxial mesoderm development (GO:0048339)2.12226197
151layer formation in cerebral cortex (GO:0021819)2.12103267
152myoblast fusion (GO:0007520)2.11566544
153endocardial cushion development (GO:0003197)2.11512342
154regulation of growth hormone secretion (GO:0060123)2.10186684
155auditory receptor cell differentiation (GO:0042491)2.10160027
156neuron projection extension (GO:1990138)2.08708862
157homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.08031216
158ectodermal placode formation (GO:0060788)2.07730412
159neurotransmitter-gated ion channel clustering (GO:0072578)2.05778799
160artery development (GO:0060840)2.05701214
161embryonic camera-type eye morphogenesis (GO:0048596)2.04644246
162endoplasmic reticulum organization (GO:0007029)2.04027145
163regulation of neuron migration (GO:2001222)2.03579393
164receptor recycling (GO:0001881)2.03272783
165lens morphogenesis in camera-type eye (GO:0002089)2.02962838
166chondrocyte proliferation (GO:0035988)2.02862572
167organelle transport along microtubule (GO:0072384)2.01819852
168hair cell differentiation (GO:0035315)2.00205876
169regulation of keratinocyte proliferation (GO:0010837)1.99951974
170cilium movement (GO:0003341)1.99903114
171spinal cord development (GO:0021510)1.99588661
172positive regulation of male gonad development (GO:2000020)1.98154066
173notochord development (GO:0030903)1.97655158
174regulation of synapse assembly (GO:0051963)1.97436748
175ovulation cycle (GO:0042698)1.97295932
176nephron tubule formation (GO:0072079)1.96651450
177nucleus localization (GO:0051647)1.96264070
178positive regulation of synapse assembly (GO:0051965)1.95951689
179appendage development (GO:0048736)1.94601791
180limb development (GO:0060173)1.94601791
181neurofilament cytoskeleton organization (GO:0060052)1.94422173

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.38193635
2RBPJ_22232070_ChIP-Seq_NCS_Mouse3.11759234
3EZH2_22144423_ChIP-Seq_EOC_Human2.56951283
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.55755098
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.49335539
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.38858234
7SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.34029241
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.31656697
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.31656697
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.30924516
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.27460370
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.25236467
13TAF15_26573619_Chip-Seq_HEK293_Human2.23969054
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.20739576
15CDX2_19796622_ChIP-Seq_MESCs_Mouse2.12490761
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.09773284
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.08249718
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.00568337
19MTF2_20144788_ChIP-Seq_MESCs_Mouse1.97938485
20JARID2_20075857_ChIP-Seq_MESCs_Mouse1.93229280
21WT1_19549856_ChIP-ChIP_CCG9911_Human1.92774455
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.92066047
23CBX2_27304074_Chip-Seq_ESCs_Mouse1.90880556
24RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.90694022
25PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.90459613
26RNF2_27304074_Chip-Seq_ESCs_Mouse1.87524262
27DROSHA_22980978_ChIP-Seq_HELA_Human1.84151791
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.82313665
29AR_21572438_ChIP-Seq_LNCaP_Human1.80743858
30* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.79050407
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.76857890
32OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.76206583
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.75611618
34IGF1R_20145208_ChIP-Seq_DFB_Human1.75239731
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.70414728
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.69038705
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.63657070
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61971089
39SMAD3_21741376_ChIP-Seq_EPCs_Human1.61159858
40FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.55746535
41TRIM28_21343339_ChIP-Seq_HEK293_Human1.55708287
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55470572
43FOXM1_26456572_ChIP-Seq_MCF-7_Human1.53189665
44ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.51598863
45ER_23166858_ChIP-Seq_MCF-7_Human1.50907080
46EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.49936783
47HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.48194561
48VDR_22108803_ChIP-Seq_LS180_Human1.47348629
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44562232
50AR_25329375_ChIP-Seq_VCAP_Human1.42744394
51EWS_26573619_Chip-Seq_HEK293_Human1.39311821
52NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.38379142
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35824225
54TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.35806510
55ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33941907
56AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33409869
57CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.30517457
58TP53_18474530_ChIP-ChIP_U2OS_Human1.30351587
59BMI1_23680149_ChIP-Seq_NPCS_Mouse1.30193001
60EP300_21415370_ChIP-Seq_HL-1_Mouse1.27246551
61YAP1_20516196_ChIP-Seq_MESCs_Mouse1.26114841
62P53_22127205_ChIP-Seq_FIBROBLAST_Human1.26004217
63* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25804084
64* HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.24664464
65TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23178698
66P300_19829295_ChIP-Seq_ESCs_Human1.22770201
67TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22382340
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21704115
69POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21704115
70BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.21499076
71ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21196723
72WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20749286
73* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.20255570
74RNF2_27304074_Chip-Seq_NSC_Mouse1.19239209
75AHR_22903824_ChIP-Seq_MCF-7_Human1.19235987
76SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.19173162
77TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.17777786
78FUS_26573619_Chip-Seq_HEK293_Human1.17110205
79SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.16904154
80* RING1B_27294783_Chip-Seq_NPCs_Mouse1.16869072
81TCF4_18268006_ChIP-ChIP_LS174T_Human1.16602576
82CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.16365458
83RING1B_27294783_Chip-Seq_ESCs_Mouse1.15815033
84TBX3_20139965_ChIP-Seq_MESCs_Mouse1.15753050
85TBX3_20139965_ChIP-Seq_ESCs_Mouse1.15732656
86GATA1_26923725_Chip-Seq_HPCs_Mouse1.15602324
87RXR_22108803_ChIP-Seq_LS180_Human1.15501952
88STAT3_23295773_ChIP-Seq_U87_Human1.15318594
89NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14916081
90AR_21909140_ChIP-Seq_LNCAP_Human1.14210320
91* CJUN_26792858_Chip-Seq_BT549_Human1.13943951
92TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11118690
93TAL1_26923725_Chip-Seq_HPCs_Mouse1.11090932
94NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10723983
95FOXO3_23340844_ChIP-Seq_DLD1_Human1.10578872
96* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.09603163
97FOXA2_19822575_ChIP-Seq_HepG2_Human1.09533454
98ISL1_27105846_Chip-Seq_CPCs_Mouse1.09310249
99SMAD4_21799915_ChIP-Seq_A2780_Human1.08625008
100ARNT_22903824_ChIP-Seq_MCF-7_Human1.07344904
101UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06080572
102ZNF274_21170338_ChIP-Seq_K562_Hela1.05683232
103MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05214250
104LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04499572
105TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.04172315
106CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.03613357
107TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03569138
108NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.03458862
109TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03382404
110KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03111213
111PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.03065690
112WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.02328008
113RUNX2_22187159_ChIP-Seq_PCA_Human1.01820590
114KDM2B_26808549_Chip-Seq_REH_Human1.00846283
115AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.99879725
116SMAD3_21741376_ChIP-Seq_HESCs_Human0.99483639
117CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99300405
118TCF4_23295773_ChIP-Seq_U87_Human0.99088761
119ESR1_20079471_ChIP-ChIP_T-47D_Human0.98423466
120SOX2_21211035_ChIP-Seq_LN229_Gbm0.98061277
121CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96786322
122NANOG_18555785_Chip-Seq_ESCs_Mouse0.96571289
123* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.96489493
124* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.96489493
125LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96048572
126CMYC_18555785_Chip-Seq_ESCs_Mouse0.95890290
127REST_21632747_ChIP-Seq_MESCs_Mouse0.95301902
128MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94086855
129SOX9_26525672_Chip-Seq_HEART_Mouse0.93968595
130EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93949372
131TP53_16413492_ChIP-PET_HCT116_Human0.93826825
132* PRDM14_20953172_ChIP-Seq_ESCs_Human0.93496814
133ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93263024

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination4.57296415
2MP0000462_abnormal_digestive_system3.10453658
3MP0003880_abnormal_central_pattern2.91191977
4MP0005171_absent_coat_pigmentation2.79014537
5MP0000778_abnormal_nervous_system2.78389678
6MP0009780_abnormal_chondrocyte_physiolo2.75907753
7MP0004270_analgesia2.57015685
8MP0004885_abnormal_endolymph2.30886991
9MP0004742_abnormal_vestibular_system2.28762637
10MP0003950_abnormal_plasma_membrane2.27410614
11MP0003690_abnormal_glial_cell2.19944189
12MP0001486_abnormal_startle_reflex2.17391348
13MP0005257_abnormal_intraocular_pressure2.12494415
14MP0000537_abnormal_urethra_morphology2.11320549
15MP0004134_abnormal_chest_morphology2.10773060
16MP0005551_abnormal_eye_electrophysiolog2.10667206
17MP0000566_synostosis2.09885901
18MP0003136_yellow_coat_color2.09415085
19MP0003890_abnormal_embryonic-extraembry2.07612393
20MP0003937_abnormal_limbs/digits/tail_de1.99305537
21MP0009384_cardiac_valve_regurgitation1.93639103
22MP0003634_abnormal_glial_cell1.92398233
23MP0001485_abnormal_pinna_reflex1.89400243
24MP0005409_darkened_coat_color1.86048682
25MP0001905_abnormal_dopamine_level1.77642630
26MP0003329_amyloid_beta_deposits1.74028559
27MP0003385_abnormal_body_wall1.70323576
28MP0002938_white_spotting1.68203660
29MP0002272_abnormal_nervous_system1.66769110
30MP0009250_abnormal_appendicular_skeleto1.64485627
31MP0003123_paternal_imprinting1.63170653
32MP0003938_abnormal_ear_development1.60530615
33MP0005248_abnormal_Harderian_gland1.56463624
34MP0008438_abnormal_cutaneous_collagen1.54499972
35MP0002752_abnormal_somatic_nervous1.53169164
36MP0004859_abnormal_synaptic_plasticity1.50884491
37MP0001529_abnormal_vocalization1.50799786
38MP0002882_abnormal_neuron_morphology1.50551241
39MP0005085_abnormal_gallbladder_physiolo1.48296945
40MP0002734_abnormal_mechanical_nocicepti1.46884219
41MP0005423_abnormal_somatic_nervous1.44650548
42MP0003941_abnormal_skin_development1.43936005
43MP0008789_abnormal_olfactory_epithelium1.43272146
44MP0003632_abnormal_nervous_system1.43071956
45MP0001299_abnormal_eye_distance/1.40101155
46MP0002229_neurodegeneration1.39710077
47MP0002009_preneoplasia1.37391140
48MP0005503_abnormal_tendon_morphology1.36369051
49MP0005195_abnormal_posterior_eye1.34792791
50MP0004272_abnormal_basement_membrane1.33947625
51MP0002909_abnormal_adrenal_gland1.31080768
52MP0003121_genomic_imprinting1.30777747
53MP0000955_abnormal_spinal_cord1.30463142
54MP0000639_abnormal_adrenal_gland1.30361552
55MP0001661_extended_life_span1.29795061
56MP0000647_abnormal_sebaceous_gland1.29683186
57MP0000026_abnormal_inner_ear1.29208763
58MP0003315_abnormal_perineum_morphology1.27478553
59MP0010678_abnormal_skin_adnexa1.27381931
60MP0000762_abnormal_tongue_morphology1.26201814
61MP0001984_abnormal_olfaction1.24298791
62MP0001963_abnormal_hearing_physiology1.22872381
63MP0000383_abnormal_hair_follicle1.22216321
64MP0003122_maternal_imprinting1.22170710
65MP0002064_seizures1.21636610
66MP0008875_abnormal_xenobiotic_pharmacok1.20556161
67MP0003935_abnormal_craniofacial_develop1.20234247
68MP0005187_abnormal_penis_morphology1.19926175
69MP0002160_abnormal_reproductive_system1.18944525
70MP0005253_abnormal_eye_physiology1.18244383
71MP0000427_abnormal_hair_cycle1.17945815
72MP0002184_abnormal_innervation1.17647425
73MP0003252_abnormal_bile_duct1.16754613
74MP0005394_taste/olfaction_phenotype1.15835864
75MP0005499_abnormal_olfactory_system1.15835864
76MP0005623_abnormal_meninges_morphology1.15448609
77MP0004147_increased_porphyrin_level1.15420715
78MP0004142_abnormal_muscle_tone1.13763859
79MP0002697_abnormal_eye_size1.13075822
80MP0010234_abnormal_vibrissa_follicle1.12025632
81MP0002896_abnormal_bone_mineralization1.10378389
82MP0001346_abnormal_lacrimal_gland1.09621431
83MP0002638_abnormal_pupillary_reflex1.09195007
84MP0002152_abnormal_brain_morphology1.07972648
85MP0000467_abnormal_esophagus_morphology1.06827570
86MP0005451_abnormal_body_composition1.05884983
87MP0002876_abnormal_thyroid_physiology1.05205484
88MP0010386_abnormal_urinary_bladder1.04438475
89MP0003868_abnormal_feces_composition1.04360158
90MP0003755_abnormal_palate_morphology1.04268881
91MP0003861_abnormal_nervous_system1.03938954
92MP0003635_abnormal_synaptic_transmissio1.03873560
93MP0004133_heterotaxia1.03349188
94MP0001270_distended_abdomen1.02814196
95MP0004381_abnormal_hair_follicle1.02526832
96MP0009745_abnormal_behavioral_response1.02256625
97MP0010352_gastrointestinal_tract_polyps1.01301834
98MP0002282_abnormal_trachea_morphology1.01139068
99MP0000631_abnormal_neuroendocrine_gland1.00457549
100MP0000613_abnormal_salivary_gland0.99511573
101MP0002653_abnormal_ependyma_morphology0.98189969
102MP0003115_abnormal_respiratory_system0.97259656
103MP0000465_gastrointestinal_hemorrhage0.96616763
104MP0006072_abnormal_retinal_apoptosis0.95869291
105MP0002108_abnormal_muscle_morphology0.95760128
106MP0001286_abnormal_eye_development0.95755262
107MP0002102_abnormal_ear_morphology0.94102359
108MP0004924_abnormal_behavior0.93904543
109MP0005386_behavior/neurological_phenoty0.93904543
110MP0001666_abnormal_nutrient_absorption0.92839468
111MP0000049_abnormal_middle_ear0.92791531
112MP0002233_abnormal_nose_morphology0.91350752
113MP0004145_abnormal_muscle_electrophysio0.91132941
114MP0002067_abnormal_sensory_capabilities0.88816022
115MP0000534_abnormal_ureter_morphology0.88676274
116MP0001177_atelectasis0.88665768
117MP0002066_abnormal_motor_capabilities/c0.88020725
118MP0006276_abnormal_autonomic_nervous0.87335390
119MP0002557_abnormal_social/conspecific_i0.86640375
120MP0003705_abnormal_hypodermis_morpholog0.86054236
121MP0005646_abnormal_pituitary_gland0.84826844
122MP0003942_abnormal_urinary_system0.84824270
123MP0000569_abnormal_digit_pigmentation0.83277581
124MP0001664_abnormal_digestion0.82782951
125MP0000428_abnormal_craniofacial_morphol0.82273239
126MP0009703_decreased_birth_body0.81956308
127MP0002063_abnormal_learning/memory/cond0.81930416
128MP0010368_abnormal_lymphatic_system0.81767519
129MP0003787_abnormal_imprinting0.80692683
130MP0005408_hypopigmentation0.80583863
131MP0003943_abnormal_hepatobiliary_system0.80568783
132MP0002932_abnormal_joint_morphology0.79043768
133MP0009046_muscle_twitch0.78764366
134MP0000432_abnormal_head_morphology0.78566705
135MP0002295_abnormal_pulmonary_circulatio0.78313319
136MP0002822_catalepsy0.77759568
137MP0005391_vision/eye_phenotype0.77268219
138MP0002572_abnormal_emotion/affect_behav0.76391964
139MP0002116_abnormal_craniofacial_bone0.76293751
140MP0000733_abnormal_muscle_development0.76133977
141MP0002092_abnormal_eye_morphology0.75332042
142MP0001188_hyperpigmentation0.74781184
143MP0002249_abnormal_larynx_morphology0.74555437
144MP0005381_digestive/alimentary_phenotyp0.74453111
145MP0005197_abnormal_uvea_morphology0.74301159
146MP0003011_delayed_dark_adaptation0.74278219
147MP0002081_perinatal_lethality0.73024474
148MP0002177_abnormal_outer_ear0.72979152
149MP0005275_abnormal_skin_tensile0.72563565

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)5.16345188
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.16345188
3Sensory axonal neuropathy (HP:0003390)4.48131316
4Neurofibrillary tangles (HP:0002185)4.31323144
5Abnormality of the corticospinal tract (HP:0002492)3.93259184
6Peripheral hypomyelination (HP:0007182)3.59035238
7Alacrima (HP:0000522)3.39826329
8Termporal pattern (HP:0011008)3.31255241
9Insidious onset (HP:0003587)3.31255241
10Parakeratosis (HP:0001036)3.28825925
11Bell-shaped thorax (HP:0001591)3.05530873
12Premature skin wrinkling (HP:0100678)3.02992296
13Akinesia (HP:0002304)2.93634643
14Cerebral inclusion bodies (HP:0100314)2.88127081
15Myelomeningocele (HP:0002475)2.86126549
16Coronal craniosynostosis (HP:0004440)2.83635541
17Synostosis involving the elbow (HP:0003938)2.82352549
18Humeroradial synostosis (HP:0003041)2.82352549
19Decreased lacrimation (HP:0000633)2.78932373
20Megalencephaly (HP:0001355)2.75679034
21Stomach cancer (HP:0012126)2.70304166
22Papillary thyroid carcinoma (HP:0002895)2.67638763
23Infantile muscular hypotonia (HP:0008947)2.65508058
24Retinal dysplasia (HP:0007973)2.65283932
25Spastic gait (HP:0002064)2.61121678
26Hepatoblastoma (HP:0002884)2.57709251
27Abnormal auditory evoked potentials (HP:0006958)2.55964588
28Hypoplasia of the iris (HP:0007676)2.54953140
29Anteriorly placed anus (HP:0001545)2.51472967
30Abnormal umbilical cord blood vessels (HP:0011403)2.51064974
31Single umbilical artery (HP:0001195)2.51064974
32Abnormality of the fetal cardiovascular system (HP:0010948)2.51064974
33Onion bulb formation (HP:0003383)2.48040036
34Blue irides (HP:0000635)2.47206433
35Chin dimple (HP:0010751)2.46910772
36Partial agenesis of the corpus callosum (HP:0001338)2.46160715
37Thickened helices (HP:0000391)2.44049960
38Abnormality of the nasal septum (HP:0000419)2.43703434
39Congenital stationary night blindness (HP:0007642)2.42962689
40Hypoplastic pelvis (HP:0008839)2.41916632
41Abnormality of the middle phalanges of the toes (HP:0010183)2.34713225
42Arterial tortuosity (HP:0005116)2.34015910
43Cupped ear (HP:0000378)2.33315706
44Bowel incontinence (HP:0002607)2.30201134
45Hyperventilation (HP:0002883)2.29880401
46White forelock (HP:0002211)2.21681592
47Keratoconus (HP:0000563)2.21030778
48Increased corneal curvature (HP:0100692)2.21030778
49Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.20190733
50Short 4th metacarpal (HP:0010044)2.20190733
51Vascular tortuosity (HP:0004948)2.17541203
52Symphalangism affecting the phalanges of the hand (HP:0009773)2.16151204
53Relative macrocephaly (HP:0004482)2.15814096
54Supranuclear gaze palsy (HP:0000605)2.15502428
55Esophageal atresia (HP:0002032)2.13198686
56Morphological abnormality of the inner ear (HP:0011390)2.13050422
57Macroorchidism (HP:0000053)2.10657136
58Back pain (HP:0003418)2.09372717
59Split foot (HP:0001839)2.08554445
60Drooling (HP:0002307)2.08046906
61Overgrowth (HP:0001548)2.07806703
62High anterior hairline (HP:0009890)2.07508880
63Curly hair (HP:0002212)2.07187522
64Anophthalmia (HP:0000528)2.04409404
65Absent septum pellucidum (HP:0001331)2.02767868
66Abolished electroretinogram (ERG) (HP:0000550)2.01103310
67Abnormal large intestine physiology (HP:0012700)2.00646484
68Abnormality of the phalanges of the 2nd finger (HP:0009541)2.00448127
69Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.99992804
70Heterotopia (HP:0002282)1.98941617
71Cone-rod dystrophy (HP:0000548)1.97911764
72Patchy hypopigmentation of hair (HP:0011365)1.97370267
73Abnormal respiratory epithelium morphology (HP:0012253)1.94992239
74Abnormal respiratory motile cilium morphology (HP:0005938)1.94992239
75Epiphyseal dysplasia (HP:0002656)1.94690155
76Intention tremor (HP:0002080)1.94287114
77Aplasia/Hypoplasia of the clavicles (HP:0006710)1.92856447
78Broad metatarsal (HP:0001783)1.91525559
79Steppage gait (HP:0003376)1.91473796
80Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.89923682
81Large earlobe (HP:0009748)1.89287478
82Hypoplastic nipples (HP:0002557)1.89179404
83Meningocele (HP:0002435)1.87070131
84Dysmetria (HP:0001310)1.85674853
85Aplasia/Hypoplasia of the brainstem (HP:0007362)1.85213589
86Hypoplasia of the brainstem (HP:0002365)1.85213589
87Congenital sensorineural hearing impairment (HP:0008527)1.84622619
88Osteomalacia (HP:0002749)1.84143879
89Long nose (HP:0003189)1.83400804
90Aplasia involving bones of the upper limbs (HP:0009823)1.83380398
91Aplasia of the phalanges of the hand (HP:0009802)1.83380398
92Aplasia involving bones of the extremities (HP:0009825)1.83380398
93Bifid scrotum (HP:0000048)1.82800523
94Excessive salivation (HP:0003781)1.81176352
95Short tibia (HP:0005736)1.80725723
96Cerebral hypomyelination (HP:0006808)1.79772980
97Abnormality of the distal phalanx of the thumb (HP:0009617)1.79222897
98Neoplasm of the oral cavity (HP:0100649)1.79000871
99Short clavicles (HP:0000894)1.78374802
100Septo-optic dysplasia (HP:0100842)1.78316847
101Cutaneous finger syndactyly (HP:0010554)1.77051279
102Action tremor (HP:0002345)1.77005623
103Urinary urgency (HP:0000012)1.76771752
104Spastic paraparesis (HP:0002313)1.76062085
105Abnormality of the ischium (HP:0003174)1.73250628
106Midline defect of the nose (HP:0004122)1.72953626
107Abnormality of macular pigmentation (HP:0008002)1.72656580
108Vertebral clefting (HP:0008428)1.70881218
109Pheochromocytoma (HP:0002666)1.70804060
110Abnormality of the septum pellucidum (HP:0007375)1.70759479
111Small epiphyses (HP:0010585)1.70530699
112Slow saccadic eye movements (HP:0000514)1.70342933
113Renal dysplasia (HP:0000110)1.70105782
114Increased number of teeth (HP:0011069)1.69743956
115Decreased central vision (HP:0007663)1.69523794
116Ulnar claw (HP:0001178)1.69338131
117Premature rupture of membranes (HP:0001788)1.68934339
118Neonatal short-limb short stature (HP:0008921)1.68808167
119Omphalocele (HP:0001539)1.68329568
120Conjugated hyperbilirubinemia (HP:0002908)1.67962563
121Abnormality of the parathyroid morphology (HP:0011766)1.67893836
122Exotropia (HP:0000577)1.67670569
123Oligodactyly (hands) (HP:0001180)1.67424224
124Overriding aorta (HP:0002623)1.66786784
125Aortic dissection (HP:0002647)1.66767423
126Pulmonic stenosis (HP:0001642)1.66594821
127Gait imbalance (HP:0002141)1.66453778
128Limited hip movement (HP:0008800)1.66239205
129Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.65612919
130Vertebral arch anomaly (HP:0008438)1.65532143
131Bronchomalacia (HP:0002780)1.64949853
132Morphological abnormality of the middle ear (HP:0008609)1.64699772
133Flat acetabular roof (HP:0003180)1.64530181
134Neoplasm of the heart (HP:0100544)1.64236870
135Abnormality of the vitreous humor (HP:0004327)1.63249935
136Wide anterior fontanel (HP:0000260)1.63095059
137Open mouth (HP:0000194)1.61572728
138Abnormality of the 4th metacarpal (HP:0010012)1.60971228
139Shallow orbits (HP:0000586)1.58503731
140Abnormality of the axillary hair (HP:0100134)1.58437314
141Abnormality of secondary sexual hair (HP:0009888)1.58437314
142Genetic anticipation (HP:0003743)1.58346583
143Thyroid carcinoma (HP:0002890)1.58047056
144Absent speech (HP:0001344)1.56296381
145Abnormality of the phalanges of the hallux (HP:0010057)1.54978785
146Congenital primary aphakia (HP:0007707)1.54672664
147Absent eyebrow (HP:0002223)1.54229214
148Cubitus valgus (HP:0002967)1.53558827
149Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.53100190
150Aplasia/Hypoplasia of the tibia (HP:0005772)1.50794087
151Vaginal atresia (HP:0000148)1.50246002
152Accelerated skeletal maturation (HP:0005616)1.49323268
153Abnormal hand bone ossification (HP:0010660)1.49002808
154Genital tract atresia (HP:0001827)1.48272385
155Mitral stenosis (HP:0001718)1.48103662
156Cortical dysplasia (HP:0002539)1.46410603
157Enlarged penis (HP:0000040)1.45817051
158Thickened nuchal skin fold (HP:0000474)1.44633430
159Poor coordination (HP:0002370)1.43721102
160Hamartoma (HP:0010566)1.43425521
161Tibial bowing (HP:0002982)1.42773579
162Absent frontal sinuses (HP:0002688)1.42352714
163Abnormality of the proximal phalanges of the hand (HP:0009834)1.42214004
164Truncal obesity (HP:0001956)1.42056531
165Aortic aneurysm (HP:0004942)1.41442278
166Bilateral sensorineural hearing impairment (HP:0008619)1.40493411
167Cystic hygroma (HP:0000476)1.39817645
168Lissencephaly (HP:0001339)1.38337810
169Male infertility (HP:0003251)1.38026558
170Diastasis recti (HP:0001540)1.37466212
171* Adrenal hypoplasia (HP:0000835)1.37123641
172Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.37013678
173Short nail (HP:0001799)1.36998687
174Cutaneous syndactyly (HP:0012725)1.36677500
175Abnormality of carpal bone ossification (HP:0006257)1.36539762
176Lip pit (HP:0100267)1.34771852
177Rhizomelia (HP:0008905)1.34300648
178Chorioretinal atrophy (HP:0000533)1.33938690
179Germ cell neoplasia (HP:0100728)1.33744237

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.85667074
2OXSR13.75198723
3TNIK3.74159509
4CSNK1A1L2.78764139
5BCR2.75600729
6CSNK1G32.74088449
7EPHB12.39257890
8CSNK1G12.27025508
9FGFR22.23501012
10CASK2.20428528
11CSNK1G22.13550546
12WNK42.11133441
13PRKD32.08398037
14LIMK11.99498882
15BRSK21.99128356
16MARK11.98703694
17MET1.86871599
18CDK191.86711212
19PKN11.86113558
20PBK1.85643377
21LMTK21.83193871
22PDGFRA1.77445162
23STK38L1.75025979
24TYRO31.70126290
25LATS11.69802732
26PRPF4B1.63676800
27DYRK21.61969260
28ERBB31.61374849
29MAP3K41.61363812
30IRAK21.55797940
31UHMK11.55538199
32NEK91.53911205
33FRK1.50834375
34EPHB21.50420408
35NEK61.43402112
36SGK21.43134288
37WNK11.38407583
38ROCK21.35121997
39TRIM281.35084383
40BRD41.34262603
41NUAK11.32327663
42EPHA21.30615744
43FGR1.27021078
44CLK11.25382003
45PHKG21.23338714
46PHKG11.23338714
47TAF11.22674509
48FER1.22255772
49NTRK21.21525252
50ERBB41.21117612
51DDR21.19232760
52MAP2K71.14601114
53IRAK11.14221057
54CAMK1G1.12565495
55PAK31.12320978
56SGK31.10471726
57MAP3K21.08353523
58WEE11.08194899
59CAMK2B1.06861737
60MAPK131.05976379
61CAMK2D1.05558024
62MAP3K61.03188080
63PIK3CA0.99392907
64PAK60.94365512
65PTK20.93748694
66STK240.92534658
67EPHA40.91910224
68MST40.89276576
69MARK20.89171109
70STK380.88927903
71PDGFRB0.88700042
72MINK10.85467049
73PNCK0.85315980
74SGK4940.82004631
75SGK2230.82004631
76MST1R0.80964258
77PKN20.80711961
78PTK60.80529693
79MELK0.80031923
80PRKCQ0.78390451
81LATS20.74495632
82PINK10.73164506
83CDK50.72483243
84ERBB20.71926411
85CDK140.70362818
86CAMK2A0.69510124
87PRKCG0.69305384
88NTRK10.68855249
89FGFR30.67899936
90DYRK1B0.67148133
91ROCK10.66316086
92MAPK150.65611154
93CAMK2G0.65383595
94MAP2K40.63268762
95FYN0.61871587
96CAMK1D0.61866068
97BMPR1B0.61584048
98EEF2K0.61198780
99DMPK0.58588002
100CAMKK20.57933562
101MAPKAPK50.57896653
102CDK150.57843475
103MTOR0.57480843
104BRSK10.56961291
105NTRK30.56874191
106CDK180.56737168
107MUSK0.55884232
108MKNK10.55638116
109PRKCH0.55622000
110CSNK1D0.55339140
111TIE10.54912237
112NEK20.54513454
113PRKG10.54292241
114SRPK10.52048998
115PRKCE0.51325020
116SIK10.50397315
117WNK30.50302517
118PRKD10.48815553
119CDK11A0.48391431
120CDK30.46409882
121DYRK1A0.44023626
122PRKD20.43772388
123ADRBK10.43345117
124PLK20.43279748
125CSNK1E0.43031569
126FES0.42985729
127MAPK70.42929942
128GRK10.42725012
129PRKAA10.39965332
130KSR10.39147350
131GSK3A0.38869123
132EPHA30.38283998
133TESK20.37852331
134CSK0.36564043
135CSNK1A10.36389013
136STK30.34189508
137INSR0.34145532
138PRKCZ0.32672148
139INSRR0.30735691
140PAK20.29586251
141FGFR10.28966021
142STK110.26607198
143RET0.26541261
144SRC0.26322110
145YES10.25321487
146PRKACA0.23710689
147AKT30.22917957

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.55303562
2Steroid biosynthesis_Homo sapiens_hsa001003.91525522
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.64067108
4Fatty acid elongation_Homo sapiens_hsa000623.11521678
5Axon guidance_Homo sapiens_hsa043602.95694847
6Phototransduction_Homo sapiens_hsa047442.81017104
7Ether lipid metabolism_Homo sapiens_hsa005652.80475244
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.21866344
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.15884274
10Sulfur metabolism_Homo sapiens_hsa009201.99180630
11Basal cell carcinoma_Homo sapiens_hsa052171.91230679
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.88265587
13Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.85656638
14Sphingolipid metabolism_Homo sapiens_hsa006001.65658728
15Renal cell carcinoma_Homo sapiens_hsa052111.64095413
16Hedgehog signaling pathway_Homo sapiens_hsa043401.58925310
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.57028671
18Circadian rhythm_Homo sapiens_hsa047101.53006532
19Adherens junction_Homo sapiens_hsa045201.47794667
20Dorso-ventral axis formation_Homo sapiens_hsa043201.41784775
21Tight junction_Homo sapiens_hsa045301.36958961
22Vitamin B6 metabolism_Homo sapiens_hsa007501.36601149
23ECM-receptor interaction_Homo sapiens_hsa045121.35689888
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.35070884
25Butanoate metabolism_Homo sapiens_hsa006501.32897087
26Glutamatergic synapse_Homo sapiens_hsa047241.26321651
27Bile secretion_Homo sapiens_hsa049761.23887327
28Pentose and glucuronate interconversions_Homo sapiens_hsa000401.20063322
29ErbB signaling pathway_Homo sapiens_hsa040121.19530547
30Protein export_Homo sapiens_hsa030601.13851902
31Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.09983638
32Aldosterone synthesis and secretion_Homo sapiens_hsa049251.08509130
33Hippo signaling pathway_Homo sapiens_hsa043901.08086734
34Lysine degradation_Homo sapiens_hsa003101.05187798
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.05081369
36Serotonergic synapse_Homo sapiens_hsa047261.04499760
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.04405278
38Retinol metabolism_Homo sapiens_hsa008301.02102289
39Phospholipase D signaling pathway_Homo sapiens_hsa040721.00865755
40Endometrial cancer_Homo sapiens_hsa052130.98462590
41Wnt signaling pathway_Homo sapiens_hsa043100.98375826
42Caffeine metabolism_Homo sapiens_hsa002320.98140140
43Linoleic acid metabolism_Homo sapiens_hsa005910.97487371
44Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96920564
45ABC transporters_Homo sapiens_hsa020100.96814596
46Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.96342162
47Ras signaling pathway_Homo sapiens_hsa040140.94962602
48Arginine and proline metabolism_Homo sapiens_hsa003300.93140899
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92851423
50Fatty acid metabolism_Homo sapiens_hsa012120.90514270
51Nicotine addiction_Homo sapiens_hsa050330.88624753
52Choline metabolism in cancer_Homo sapiens_hsa052310.88207697
53Ovarian steroidogenesis_Homo sapiens_hsa049130.86299824
54Fatty acid biosynthesis_Homo sapiens_hsa000610.86273032
55AMPK signaling pathway_Homo sapiens_hsa041520.85832298
56Starch and sucrose metabolism_Homo sapiens_hsa005000.84960434
57Gap junction_Homo sapiens_hsa045400.84313543
58GABAergic synapse_Homo sapiens_hsa047270.83813530
59Chemical carcinogenesis_Homo sapiens_hsa052040.82398062
60Amphetamine addiction_Homo sapiens_hsa050310.82118052
61Histidine metabolism_Homo sapiens_hsa003400.77979358
62Thyroid hormone synthesis_Homo sapiens_hsa049180.77575787
63Prostate cancer_Homo sapiens_hsa052150.77357055
64Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77341840
65Focal adhesion_Homo sapiens_hsa045100.77311197
66Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.76850548
67Protein digestion and absorption_Homo sapiens_hsa049740.76215953
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75172622
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.75020551
70Regulation of actin cytoskeleton_Homo sapiens_hsa048100.74935722
71Cholinergic synapse_Homo sapiens_hsa047250.73435624
72Morphine addiction_Homo sapiens_hsa050320.73388269
73PI3K-Akt signaling pathway_Homo sapiens_hsa041510.72318008
74Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.71241712
75Circadian entrainment_Homo sapiens_hsa047130.70273804
76Dilated cardiomyopathy_Homo sapiens_hsa054140.70240232
77Cardiac muscle contraction_Homo sapiens_hsa042600.69558197
78Pancreatic secretion_Homo sapiens_hsa049720.69533974
79Thyroid cancer_Homo sapiens_hsa052160.69474481
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.67898115
81Melanoma_Homo sapiens_hsa052180.66706063
82Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65727099
83Complement and coagulation cascades_Homo sapiens_hsa046100.65601496
84Selenocompound metabolism_Homo sapiens_hsa004500.65243094
85beta-Alanine metabolism_Homo sapiens_hsa004100.64540085
86Vibrio cholerae infection_Homo sapiens_hsa051100.63897160
87Salivary secretion_Homo sapiens_hsa049700.62550623
88Cyanoamino acid metabolism_Homo sapiens_hsa004600.62381563
89Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.62337496
90Taste transduction_Homo sapiens_hsa047420.61870665
91Fat digestion and absorption_Homo sapiens_hsa049750.61562890
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.61081749
93PPAR signaling pathway_Homo sapiens_hsa033200.60934884
94Long-term depression_Homo sapiens_hsa047300.60555111
95FoxO signaling pathway_Homo sapiens_hsa040680.59866928
96TGF-beta signaling pathway_Homo sapiens_hsa043500.59862846
97cAMP signaling pathway_Homo sapiens_hsa040240.59787432
98Oxidative phosphorylation_Homo sapiens_hsa001900.59618316
99Insulin secretion_Homo sapiens_hsa049110.59272523
100Tyrosine metabolism_Homo sapiens_hsa003500.59062593
101Alzheimers disease_Homo sapiens_hsa050100.58993746
102Propanoate metabolism_Homo sapiens_hsa006400.58009653
103Estrogen signaling pathway_Homo sapiens_hsa049150.57730752
104Long-term potentiation_Homo sapiens_hsa047200.56621962
105Peroxisome_Homo sapiens_hsa041460.56554308
106Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56313956
107Cocaine addiction_Homo sapiens_hsa050300.55509046
108Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54934682
109Olfactory transduction_Homo sapiens_hsa047400.54140729
110Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52796432
111Notch signaling pathway_Homo sapiens_hsa043300.52282150
112Mineral absorption_Homo sapiens_hsa049780.52237447
113Endocytosis_Homo sapiens_hsa041440.51174969
114MicroRNAs in cancer_Homo sapiens_hsa052060.51161735
115Pathways in cancer_Homo sapiens_hsa052000.50182014
116Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46377927
117Arachidonic acid metabolism_Homo sapiens_hsa005900.46358929
118Malaria_Homo sapiens_hsa051440.46286847
119Glutathione metabolism_Homo sapiens_hsa004800.46231169
120Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46050356
121Dopaminergic synapse_Homo sapiens_hsa047280.45339881
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44224017
123Alcoholism_Homo sapiens_hsa050340.43721347
124Rap1 signaling pathway_Homo sapiens_hsa040150.42675673
125Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42058792
126Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.41358859
127Vitamin digestion and absorption_Homo sapiens_hsa049770.40766933
128Colorectal cancer_Homo sapiens_hsa052100.40434006
129Melanogenesis_Homo sapiens_hsa049160.40375241
130Proteoglycans in cancer_Homo sapiens_hsa052050.40247653
131MAPK signaling pathway_Homo sapiens_hsa040100.38955960
132Primary bile acid biosynthesis_Homo sapiens_hsa001200.37942666
133GnRH signaling pathway_Homo sapiens_hsa049120.37765770
134Glioma_Homo sapiens_hsa052140.37212182
135Glycerophospholipid metabolism_Homo sapiens_hsa005640.37114278
136SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37093219

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »