ICMT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)5.46017158
2sodium ion export (GO:0071436)5.44336048
3cellular potassium ion homeostasis (GO:0030007)5.31250088
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.23883174
5rhodopsin mediated signaling pathway (GO:0016056)5.18207477
6regulation of rhodopsin mediated signaling pathway (GO:0022400)5.09373629
7DNA unwinding involved in DNA replication (GO:0006268)4.97732819
8synaptic vesicle maturation (GO:0016188)4.66127349
9nuclear pore complex assembly (GO:0051292)4.64744943
10retinal cone cell development (GO:0046549)4.59963220
11regulation of short-term neuronal synaptic plasticity (GO:0048172)4.47305095
12locomotory exploration behavior (GO:0035641)4.30803277
13cerebellar granule cell differentiation (GO:0021707)4.30332830
14mitotic chromosome condensation (GO:0007076)4.29544909
15COPI coating of Golgi vesicle (GO:0048205)4.20712529
16Golgi transport vesicle coating (GO:0048200)4.20712529
17cerebellar Purkinje cell differentiation (GO:0021702)4.13845025
18protein complex localization (GO:0031503)4.12953935
19nuclear pore organization (GO:0006999)4.12541719
20cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.12445788
21regulation of clathrin-mediated endocytosis (GO:2000369)4.11772269
22cellular protein complex localization (GO:0034629)4.06043162
23detection of light stimulus involved in visual perception (GO:0050908)4.01451408
24detection of light stimulus involved in sensory perception (GO:0050962)4.01451408
25paraxial mesoderm development (GO:0048339)3.92096685
26photoreceptor cell development (GO:0042461)3.87093617
27regulation of translational fidelity (GO:0006450)3.81860263
28positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.77601022
29protein retention in ER lumen (GO:0006621)3.75437182
30potassium ion import (GO:0010107)3.69794560
31gamma-aminobutyric acid transport (GO:0015812)3.67525218
32positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.64719122
33maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.64167453
34potassium ion homeostasis (GO:0055075)3.64128554
35proline biosynthetic process (GO:0006561)3.62503212
36glutamate secretion (GO:0014047)3.61180321
37eye photoreceptor cell development (GO:0042462)3.58909462
38phototransduction (GO:0007602)3.57818058
39planar cell polarity pathway involved in neural tube closure (GO:0090179)3.56511065
40cell communication by electrical coupling (GO:0010644)3.53202884
41neurotransmitter secretion (GO:0007269)3.52569650
42layer formation in cerebral cortex (GO:0021819)3.50564694
43neuronal action potential propagation (GO:0019227)3.49497321
44positive regulation of synapse maturation (GO:0090129)3.49242325
45detection of light stimulus (GO:0009583)3.48063494
46cellular sodium ion homeostasis (GO:0006883)3.47567792
47positive regulation of guanylate cyclase activity (GO:0031284)3.47063024
48regulation of synaptic vesicle exocytosis (GO:2000300)3.47004514
49establishment of integrated proviral latency (GO:0075713)3.46595297
50protein localization to chromosome, centromeric region (GO:0071459)3.44976221
51DNA strand elongation involved in DNA replication (GO:0006271)3.44619353
52regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.43579247
53synaptic vesicle exocytosis (GO:0016079)3.42444277
54G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.41907627
55DNA strand elongation (GO:0022616)3.41873113
56synaptic vesicle docking involved in exocytosis (GO:0016081)3.41375558
57retinal rod cell development (GO:0046548)3.39533540
58heterochromatin organization (GO:0070828)3.35576006
59cell differentiation in hindbrain (GO:0021533)3.33138111
60negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.31642295
61pore complex assembly (GO:0046931)3.31035674
62regulation of voltage-gated calcium channel activity (GO:1901385)3.30867133
63CDP-diacylglycerol biosynthetic process (GO:0016024)3.30642845
64positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.28623316
65regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.28483364
66phototransduction, visible light (GO:0007603)3.26699988
67adherens junction assembly (GO:0034333)3.24835170
68regulation of ARF protein signal transduction (GO:0032012)3.24465793
69detection of visible light (GO:0009584)3.21475319
70CDP-diacylglycerol metabolic process (GO:0046341)3.20960606
71photoreceptor cell maintenance (GO:0045494)3.20383715
72cytoskeletal anchoring at plasma membrane (GO:0007016)3.20248306
73mitotic sister chromatid segregation (GO:0000070)3.17401277
74regulation of guanylate cyclase activity (GO:0031282)3.16155119
75neuromuscular process controlling posture (GO:0050884)3.14690749
76regulation of mammary gland epithelial cell proliferation (GO:0033599)3.13669341
77nucleobase-containing small molecule interconversion (GO:0015949)3.12829281
78DNA replication initiation (GO:0006270)3.10636038
79protein localization to kinetochore (GO:0034501)3.10018034
80establishment of nucleus localization (GO:0040023)3.09866120
81focal adhesion assembly (GO:0048041)3.06784148
82cell-substrate adherens junction assembly (GO:0007045)3.06784148
83regulation of translational termination (GO:0006449)3.05637305
84establishment of apical/basal cell polarity (GO:0035089)3.04217215
85regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.01770317
86protein maturation by protein folding (GO:0022417)3.01635362
87mating behavior (GO:0007617)3.01550282
88vocalization behavior (GO:0071625)2.95989473
89regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.95150635
90regulation of synaptic vesicle transport (GO:1902803)2.94938668
91activation of protein kinase A activity (GO:0034199)2.94019804
92negative regulation of hormone metabolic process (GO:0032351)2.93980335
93negative regulation of hormone biosynthetic process (GO:0032353)2.93980335
94membrane repolarization (GO:0086009)2.93717944
95protein-chromophore linkage (GO:0018298)2.93414386
96neuromuscular process controlling balance (GO:0050885)2.92843497
97membrane depolarization during action potential (GO:0086010)2.92270238
98sister chromatid segregation (GO:0000819)2.89984778
99cell-substrate junction assembly (GO:0007044)2.89059046
100notochord development (GO:0030903)2.88252138
101glutamate receptor signaling pathway (GO:0007215)2.86827869
102neurotransmitter transport (GO:0006836)2.85405420
103cell communication involved in cardiac conduction (GO:0086065)2.85060713
104synaptic transmission, glutamatergic (GO:0035249)2.83296809
105ionotropic glutamate receptor signaling pathway (GO:0035235)2.80537277
106positive regulation of sodium ion transmembrane transport (GO:1902307)2.79894047
107membrane hyperpolarization (GO:0060081)2.79649193
108dicarboxylic acid biosynthetic process (GO:0043650)2.78190782
109formation of translation preinitiation complex (GO:0001731)2.76780923
110hemidesmosome assembly (GO:0031581)2.76559104
111macroautophagy (GO:0016236)2.74818342
112telomere maintenance via semi-conservative replication (GO:0032201)2.73338439
113protein localization to synapse (GO:0035418)2.72948513
114epithelial cell-cell adhesion (GO:0090136)2.72639525
115retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.72402581
116mitotic metaphase plate congression (GO:0007080)2.71505443
117skin morphogenesis (GO:0043589)2.70063174
118visual perception (GO:0007601)2.68911246
119endothelial cell morphogenesis (GO:0001886)2.68759934
120detection of external stimulus (GO:0009581)2.67496924
121basement membrane organization (GO:0071711)2.66660348
122chemosensory behavior (GO:0007635)2.66508864
123convergent extension (GO:0060026)2.65431293
124long-term memory (GO:0007616)2.64798478
125sensory perception of light stimulus (GO:0050953)2.64734974
126positive regulation of potassium ion transmembrane transport (GO:1901381)2.64430179
127regulation of mitotic spindle organization (GO:0060236)2.63619024
128neuron-neuron synaptic transmission (GO:0007270)2.63480913
129mitotic nuclear envelope disassembly (GO:0007077)2.63425254
130mitotic sister chromatid cohesion (GO:0007064)2.62383099
131peptidyl-arginine omega-N-methylation (GO:0035247)2.62344298
132chromosome condensation (GO:0030261)2.62312804
133glycine transport (GO:0015816)2.61853449
134desmosome organization (GO:0002934)2.61172984
135peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.60582487
136DNA duplex unwinding (GO:0032508)2.59497786
137C4-dicarboxylate transport (GO:0015740)2.59218355
138positive regulation of sodium ion transport (GO:0010765)2.59131685
139detection of abiotic stimulus (GO:0009582)2.58312246
140gamma-aminobutyric acid signaling pathway (GO:0007214)2.57864429
141regulation of cholesterol homeostasis (GO:2000188)2.57801973
142membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.55533488
143Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.54965505
144hippo signaling (GO:0035329)2.53924518
145protein localization to endosome (GO:0036010)2.52698304
146ribosome assembly (GO:0042255)2.51721775
147NADH metabolic process (GO:0006734)2.51695808
148mitotic nuclear envelope reassembly (GO:0007084)2.51290390
149nuclear envelope reassembly (GO:0031468)2.51290390
150membrane disassembly (GO:0030397)2.50400056
151nuclear envelope disassembly (GO:0051081)2.50400056
152histone arginine methylation (GO:0034969)2.49380049
153positive regulation of chromosome segregation (GO:0051984)2.49345267
154establishment of viral latency (GO:0019043)2.48771227
155plasma membrane repair (GO:0001778)2.48467028
156regulation of neurotransmitter levels (GO:0001505)2.47146814
157photoreceptor cell differentiation (GO:0046530)2.46533373
158eye photoreceptor cell differentiation (GO:0001754)2.46533373
159ventricular cardiac muscle cell development (GO:0055015)2.46496989
160regulation of excitatory postsynaptic membrane potential (GO:0060079)2.45218631
161synaptic vesicle endocytosis (GO:0048488)2.44894697
162dendrite morphogenesis (GO:0048813)2.44858639
163exploration behavior (GO:0035640)2.44258470
164long term synaptic depression (GO:0060292)2.43690567
165prepulse inhibition (GO:0060134)2.42360627
166regulation of establishment of planar polarity (GO:0090175)2.42320190
167DNA geometric change (GO:0032392)2.40473796
168regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.37459169
169regulation of spindle organization (GO:0090224)2.36349048
170protein localization to microtubule (GO:0035372)2.35736175
171positive regulation of DNA-dependent DNA replication (GO:2000105)2.35500438
172DNA replication checkpoint (GO:0000076)2.34702392
173nucleotide-sugar biosynthetic process (GO:0009226)2.34540240
174L-serine metabolic process (GO:0006563)2.34396645
175ribosomal small subunit biogenesis (GO:0042274)2.31753834
176gap junction assembly (GO:0016264)2.30925727
177protein hydroxylation (GO:0018126)2.30591157
178mitochondrial fusion (GO:0008053)2.30290159
179nuclear envelope organization (GO:0006998)2.29854560
180mRNA stabilization (GO:0048255)2.25694530
181RNA stabilization (GO:0043489)2.25694530
182muscle cell migration (GO:0014812)2.25340609
183pentose-phosphate shunt (GO:0006098)2.24974506
184proline metabolic process (GO:0006560)2.24805434
185G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.24756441
186regulation of early endosome to late endosome transport (GO:2000641)2.24054986
187spliceosomal tri-snRNP complex assembly (GO:0000244)2.23461571
188mitotic cytokinesis (GO:0000281)2.23160327
189regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.22421789
190folic acid metabolic process (GO:0046655)2.21155720
191regulation of sister chromatid cohesion (GO:0007063)2.21046412
192protein export from nucleus (GO:0006611)2.20878478
193regulation of cardioblast differentiation (GO:0051890)2.20638639
194activation of Rac GTPase activity (GO:0032863)2.20455683
195negative regulation of cell fate specification (GO:0009996)2.20276523
196IMP metabolic process (GO:0046040)2.20072800
197bone trabecula formation (GO:0060346)2.19833762
198positive regulation of SMAD protein import into nucleus (GO:0060391)2.19734934

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.35180511
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.71274297
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.22785574
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.13903748
5AR_21909140_ChIP-Seq_LNCAP_Human2.86546713
6EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.82386588
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.78807082
8DROSHA_22980978_ChIP-Seq_HELA_Human2.64870584
9EZH2_22144423_ChIP-Seq_EOC_Human2.53319489
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.43961798
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.38465257
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.30067047
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.28437601
14MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.26019176
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.24826395
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.17981706
17KDM2B_26808549_Chip-Seq_K562_Human2.13670658
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.12001727
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.11754967
20ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.08201311
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.05964089
22ZFX_18555785_ChIP-Seq_MESCs_Mouse2.02193804
23ZNF263_19887448_ChIP-Seq_K562_Human1.97816696
24NELFA_20434984_ChIP-Seq_ESCs_Mouse1.94895320
25MTF2_20144788_ChIP-Seq_MESCs_Mouse1.94714979
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.92405983
27IKZF1_21737484_ChIP-ChIP_HCT116_Human1.91455502
28POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.91133690
29* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.88966135
30* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.88966135
31* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.87646354
32XRN2_22483619_ChIP-Seq_HELA_Human1.87560348
33DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.85818826
34E2F4_17652178_ChIP-ChIP_JURKAT_Human1.81947946
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.81923021
36PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.81711205
37THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.79592173
38* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.76855314
39REST_21632747_ChIP-Seq_MESCs_Mouse1.75654513
40ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.74888225
41TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.72529116
42EZH2_27294783_Chip-Seq_ESCs_Mouse1.70688054
43* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.70047063
44SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.69210079
45GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.68390523
46REST_18959480_ChIP-ChIP_MESCs_Mouse1.68214652
47EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.66795177
48* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.65407201
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.64585739
50CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.64500879
51SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.64194991
52ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.63315334
53E2F1_21310950_ChIP-Seq_MCF-7_Human1.61491799
54MYCN_18555785_ChIP-Seq_MESCs_Mouse1.58961568
55ELK3_25401928_ChIP-Seq_HUVEC_Human1.57876295
56LXR_22292898_ChIP-Seq_THP-1_Human1.57517539
57JARID2_20075857_ChIP-Seq_MESCs_Mouse1.56216369
58ZFP281_18757296_ChIP-ChIP_E14_Mouse1.53869436
59NANOG_18555785_ChIP-Seq_MESCs_Mouse1.53743638
60* KDM2B_26808549_Chip-Seq_DND41_Human1.53344951
61TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.52313221
62TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.52224523
63RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.51901069
64SUZ12_27294783_Chip-Seq_ESCs_Mouse1.50393277
65TRIM28_21343339_ChIP-Seq_HEK293_Human1.50341858
66CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.50275674
67E2F1_18555785_ChIP-Seq_MESCs_Mouse1.49942059
68CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.49910039
69* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.49269529
70NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.48349280
71KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.47671114
72POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.46691147
73NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.43533043
74KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.41370615
75SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.41271292
76DNAJC2_21179169_ChIP-ChIP_NT2_Human1.40112673
77TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40036430
78DCP1A_22483619_ChIP-Seq_HELA_Human1.39815032
79RNF2_27304074_Chip-Seq_ESCs_Mouse1.39707497
80JARID2_20064375_ChIP-Seq_MESCs_Mouse1.39230583
81RXR_22158963_ChIP-Seq_LIVER_Mouse1.39066037
82* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.36941786
83SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.36783754
84SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.36314830
85WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.35976393
86* KDM2B_26808549_Chip-Seq_JURKAT_Human1.35298680
87CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.33913796
88ATF3_27146783_Chip-Seq_COLON_Human1.32540542
89HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.31845179
90SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.31446550
91SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.30536163
92STAT3_1855785_ChIP-Seq_MESCs_Mouse1.30483873
93EGR1_19374776_ChIP-ChIP_THP-1_Human1.30187032
94TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30104209
95TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.29585367
96MYC_22102868_ChIP-Seq_BL_Human1.28900451
97LXR_22158963_ChIP-Seq_LIVER_Mouse1.28600595
98ESR2_21235772_ChIP-Seq_MCF-7_Human1.28560218
99AR_19668381_ChIP-Seq_PC3_Human1.27251510
100SMC4_20622854_ChIP-Seq_HELA_Human1.26951706
101SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.26691037
102ZFP281_27345836_Chip-Seq_ESCs_Mouse1.26330429
103NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.26212707
104FOXA2_19822575_ChIP-Seq_HepG2_Human1.25771397
105PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.25499388
106JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.25101041
107NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.23903730
108TTF2_22483619_ChIP-Seq_HELA_Human1.23788088
109SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23695514
110CREB1_15753290_ChIP-ChIP_HEK293T_Human1.22005680
111CHD1_26751641_Chip-Seq_LNCaP_Human1.22000245
112* CREB1_26743006_Chip-Seq_LNCaP_Human1.21983754
113WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21498952
114TET1_21490601_ChIP-Seq_MESCs_Mouse1.20150302
115MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.17877711
116EP300_21415370_ChIP-Seq_HL-1_Mouse1.17490606
117ZNF274_21170338_ChIP-Seq_K562_Hela1.17252439
118RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.17116953
119ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.17026603
120KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.16668000
121PPARA_22158963_ChIP-Seq_LIVER_Mouse1.16259834
122CLOCK_20551151_ChIP-Seq_293T_Human1.16156059
123BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.14990301
124* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.14876124
125TCF3_18692474_ChIP-Seq_MEFs_Mouse1.14843810
126* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.13290950
127EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.12510562
128* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.12442581
129ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11115744
130* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.10970530
131* CTCF_27219007_Chip-Seq_Bcells_Human1.09921803
132ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09657771
133UBF1/2_26484160_Chip-Seq_HMECs_Human1.08809191
134P68_20966046_ChIP-Seq_HELA_Human1.08530827
135TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.08349857
136EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.07929573
137* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07367555
138* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.06442685
139ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.06272379
140PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06010998
141ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.04798663
142ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.04337788
143TBX20_22080862_ChIP-Seq_HEART_Mouse1.04130582
144TBX20_22328084_ChIP-Seq_HEART_Mouse1.04130582
145SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.03678682
146HIF1A_21447827_ChIP-Seq_MCF-7_Human1.03528199
147KLF4_19829295_ChIP-Seq_ESCs_Human1.03466401
148EED_16625203_ChIP-ChIP_MESCs_Mouse1.03391841
149* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.03046850
150ESR1_20079471_ChIP-ChIP_T-47D_Human1.02826987
151TET1_21451524_ChIP-Seq_MESCs_Mouse1.02441154
152TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.02310467
153PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.02215320
154SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.01606457
155NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.01444398
156NANOG_21062744_ChIP-ChIP_HESCs_Human1.01085342
157GATA1_19941826_ChIP-Seq_K562_Human1.00341175
158ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99905730
159* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.99838244
160* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.99328711
161SOX17_20123909_ChIP-Seq_XEN_Mouse0.99190381
162* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97928305
163* GABP_19822575_ChIP-Seq_HepG2_Human0.97776931
164TP53_22127205_ChIP-Seq_IMR90_Human0.97462874
165SMAD3_21741376_ChIP-Seq_HESCs_Human0.97352349
166YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97107274
167DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95635581
168SMAD4_21741376_ChIP-Seq_HESCs_Human0.95548939
169SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.93963153
170SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.93963153
171GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.93104622
172RING1B_27294783_Chip-Seq_ESCs_Mouse0.92880799
173RUNX1_27514584_Chip-Seq_MCF-7_Human0.92765187
174CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.92239668
175ZNF217_24962896_ChIP-Seq_MCF-7_Human0.91509524
176EZH2_27304074_Chip-Seq_ESCs_Mouse0.90815065
177OCT4_19829295_ChIP-Seq_ESCs_Human0.90276116
178MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.89860723
179* TP63_22573176_ChIP-Seq_HFKS_Human0.89646010
180RACK7_27058665_Chip-Seq_MCF-7_Human0.89358809
181RING1B_27294783_Chip-Seq_NPCs_Mouse0.89252803
182SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88140010
183NR3C1_23031785_ChIP-Seq_PC12_Mouse0.88062074
184SOX2_21211035_ChIP-Seq_LN229_Gbm0.87425217
185STAT6_21828071_ChIP-Seq_BEAS2B_Human0.87287066
186TCF7_22412390_ChIP-Seq_EML_Mouse0.85908727
187CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84652428

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog5.00531839
2MP0003011_delayed_dark_adaptation4.85430016
3MP0004859_abnormal_synaptic_plasticity4.03951382
4MP0008438_abnormal_cutaneous_collagen3.48447217
5MP0009046_muscle_twitch3.26413727
6MP0006072_abnormal_retinal_apoptosis3.17340169
7MP0005253_abnormal_eye_physiology3.09173377
8MP0004272_abnormal_basement_membrane2.87274772
9MP0010352_gastrointestinal_tract_polyps2.77098784
10MP0003941_abnormal_skin_development2.66280924
11MP0002877_abnormal_melanocyte_morpholog2.63088559
12MP0003635_abnormal_synaptic_transmissio2.62165497
13MP0003566_abnormal_cell_adhesion2.50546149
14MP0010030_abnormal_orbit_morphology2.50283128
15MP0003111_abnormal_nucleus_morphology2.42304415
16MP0004270_analgesia2.39143427
17MP0004957_abnormal_blastocyst_morpholog2.34025185
18MP0003693_abnormal_embryo_hatching2.32208082
19MP0004145_abnormal_muscle_electrophysio2.31447799
20MP0008569_lethality_at_weaning2.30553268
21MP0003705_abnormal_hypodermis_morpholog2.29001025
22MP0005257_abnormal_intraocular_pressure2.16611920
23MP0003329_amyloid_beta_deposits2.16116516
24MP0005423_abnormal_somatic_nervous2.11008511
25MP0002272_abnormal_nervous_system2.03109554
26MP0000537_abnormal_urethra_morphology1.99658517
27MP0001968_abnormal_touch/_nociception1.98885257
28MP0002229_neurodegeneration1.96690933
29MP0002090_abnormal_vision1.94120199
30MP0002064_seizures1.93341405
31MP0005195_abnormal_posterior_eye1.88338128
32MP0004885_abnormal_endolymph1.87285060
33MP0010094_abnormal_chromosome_stability1.86700750
34MP0008932_abnormal_embryonic_tissue1.85725331
35MP0004233_abnormal_muscle_weight1.81535598
36MP0002734_abnormal_mechanical_nocicepti1.80820747
37MP0001730_embryonic_growth_arrest1.76589162
38MP0003077_abnormal_cell_cycle1.72616925
39MP0009745_abnormal_behavioral_response1.71641532
40MP0004185_abnormal_adipocyte_glucose1.68200864
41MP0001849_ear_inflammation1.67902575
42MP0002063_abnormal_learning/memory/cond1.67604079
43MP0002067_abnormal_sensory_capabilities1.64346812
44MP0003950_abnormal_plasma_membrane1.62106101
45MP0002796_impaired_skin_barrier1.56570940
46MP0002909_abnormal_adrenal_gland1.54469329
47MP0009053_abnormal_anal_canal1.50890210
48MP0010234_abnormal_vibrissa_follicle1.50844530
49MP0009672_abnormal_birth_weight1.48294408
50MP0000751_myopathy1.48072442
51MP0001661_extended_life_span1.48047266
52MP0002060_abnormal_skin_morphology1.47895679
53MP0002736_abnormal_nociception_after1.46282842
54MP0005076_abnormal_cell_differentiation1.44917667
55MP0005275_abnormal_skin_tensile1.44279030
56MP0001324_abnormal_eye_pigmentation1.43873955
57MP0008961_abnormal_basal_metabolism1.40488162
58MP0005501_abnormal_skin_physiology1.39953958
59MP0005083_abnormal_biliary_tract1.39681326
60MP0002184_abnormal_innervation1.39062788
61MP0005360_urolithiasis1.38515722
62MP0003045_fibrosis1.37725059
63MP0001672_abnormal_embryogenesis/_devel1.37421887
64MP0005380_embryogenesis_phenotype1.37421887
65MP0000733_abnormal_muscle_development1.37305673
66MP0002653_abnormal_ependyma_morphology1.36707803
67* MP0000350_abnormal_cell_proliferation1.36644336
68MP0004858_abnormal_nervous_system1.35449670
69MP0002882_abnormal_neuron_morphology1.35130493
70MP0005391_vision/eye_phenotype1.34969949
71MP0002572_abnormal_emotion/affect_behav1.34788058
72MP0000762_abnormal_tongue_morphology1.32433318
73MP0001346_abnormal_lacrimal_gland1.30140504
74MP0001502_abnormal_circadian_rhythm1.29149693
75MP0003984_embryonic_growth_retardation1.28233404
76MP0001486_abnormal_startle_reflex1.27476265
77MP0001440_abnormal_grooming_behavior1.26489261
78MP0003632_abnormal_nervous_system1.26356465
79MP0005503_abnormal_tendon_morphology1.25846888
80MP0000013_abnormal_adipose_tissue1.25707138
81* MP0002085_abnormal_embryonic_tissue1.25675557
82MP0002084_abnormal_developmental_patter1.24864075
83MP0005187_abnormal_penis_morphology1.24492679
84MP0005451_abnormal_body_composition1.22893776
85MP0002697_abnormal_eye_size1.21615115
86MP0002139_abnormal_hepatobiliary_system1.21489510
87MP0002735_abnormal_chemical_nociception1.21471080
88MP0000747_muscle_weakness1.21339461
89MP0004036_abnormal_muscle_relaxation1.20905171
90* MP0002080_prenatal_lethality1.20687230
91MP0002088_abnormal_embryonic_growth/wei1.20065421
92MP0004084_abnormal_cardiac_muscle1.19798728
93MP0000428_abnormal_craniofacial_morphol1.18223675
94MP0000604_amyloidosis1.18063322
95MP0005623_abnormal_meninges_morphology1.17919607
96MP0000749_muscle_degeneration1.16388013
97MP0005409_darkened_coat_color1.15942548
98MP0009780_abnormal_chondrocyte_physiolo1.15688400
99MP0010368_abnormal_lymphatic_system1.15039349
100MP0008057_abnormal_DNA_replication1.14511277
101MP0003633_abnormal_nervous_system1.14176888
102MP0004215_abnormal_myocardial_fiber1.13521125
103MP0000759_abnormal_skeletal_muscle1.12926007
104MP0002733_abnormal_thermal_nociception1.11999958
105MP0003942_abnormal_urinary_system1.11077843
106MP0002752_abnormal_somatic_nervous1.09975656
107MP0000534_abnormal_ureter_morphology1.09411354
108MP0003937_abnormal_limbs/digits/tail_de1.09330461
109MP0004811_abnormal_neuron_physiology1.09228690
110* MP0001697_abnormal_embryo_size1.09022811
111MP0002086_abnormal_extraembryonic_tissu1.08799959
112MP0001501_abnormal_sleep_pattern1.07868091
113MP0003385_abnormal_body_wall1.07638007
114MP0000566_synostosis1.07094806
115MP0003283_abnormal_digestive_organ1.06727387
116MP0008007_abnormal_cellular_replicative1.06701348
117MP0003091_abnormal_cell_migration1.06153651
118MP0010307_abnormal_tumor_latency1.05165240
119MP0003631_nervous_system_phenotype1.04782847
120MP0005386_behavior/neurological_phenoty1.03798334
121MP0004924_abnormal_behavior1.03798334
122MP0001970_abnormal_pain_threshold1.03749797
123MP0003279_aneurysm1.03553996
124MP0003252_abnormal_bile_duct1.02910975
125MP0005330_cardiomyopathy1.02270394
126MP0002066_abnormal_motor_capabilities/c1.02175565
127MP0005023_abnormal_wound_healing1.01827257
128MP0004043_abnormal_pH_regulation1.00969333
129MP0000955_abnormal_spinal_cord1.00673071
130MP0010329_abnormal_lipoprotein_level0.99969906
131MP0001958_emphysema0.99197688
132MP0000467_abnormal_esophagus_morphology0.98966301
133MP0000750_abnormal_muscle_regeneration0.98822922
134MP0009384_cardiac_valve_regurgitation0.97500988
135MP0003634_abnormal_glial_cell0.96247416
136MP0003453_abnormal_keratinocyte_physiol0.95819759
137MP0003315_abnormal_perineum_morphology0.95785093
138MP0000579_abnormal_nail_morphology0.95335755
139MP0009840_abnormal_foam_cell0.94798643
140MP0001984_abnormal_olfaction0.92245785
141MP0002269_muscular_atrophy0.92201422
142MP0000432_abnormal_head_morphology0.91263477
143MP0003115_abnormal_respiratory_system0.90771388
144MP0004130_abnormal_muscle_cell0.90323855
145MP0002896_abnormal_bone_mineralization0.90173629
146MP0002092_abnormal_eye_morphology0.90081461
147MP0010630_abnormal_cardiac_muscle0.90062454
148MP0000462_abnormal_digestive_system0.89388981
149MP0005197_abnormal_uvea_morphology0.88147679
150MP0004197_abnormal_fetal_growth/weight/0.88057877
151MP0001299_abnormal_eye_distance/0.87719982
152MP0002254_reproductive_system_inflammat0.86739802
153MP0004087_abnormal_muscle_fiber0.86251865
154MP0005365_abnormal_bile_salt0.85769411
155MP0002089_abnormal_postnatal_growth/wei0.85281713
156MP0005508_abnormal_skeleton_morphology0.84616431
157MP0002111_abnormal_tail_morphology0.83419192
158MP0002638_abnormal_pupillary_reflex0.83357079
159MP0000678_abnormal_parathyroid_gland0.82947250
160MP0009250_abnormal_appendicular_skeleto0.82720486
161MP0000003_abnormal_adipose_tissue0.82562215
162MP0003690_abnormal_glial_cell0.81453335
163MP0004264_abnormal_extraembryonic_tissu0.81389177
164MP0001915_intracranial_hemorrhage0.81354409
165MP0003879_abnormal_hair_cell0.81072825
166MP0004147_increased_porphyrin_level0.80198094
167MP0005410_abnormal_fertilization0.79393339
168MP0003935_abnormal_craniofacial_develop0.78981514
169MP0008875_abnormal_xenobiotic_pharmacok0.78702530
170MP0005621_abnormal_cell_physiology0.78545943
171MP0001243_abnormal_dermal_layer0.77642825
172MP0002108_abnormal_muscle_morphology0.77315737
173MP0005375_adipose_tissue_phenotype0.77016226
174MP0004019_abnormal_vitamin_homeostasis0.76963030
175MP0002837_dystrophic_cardiac_calcinosis0.75332888
176MP0003646_muscle_fatigue0.75266069
177MP0002557_abnormal_social/conspecific_i0.75090088
178MP0004085_abnormal_heartbeat0.75065382
179* MP0002152_abnormal_brain_morphology0.72319310
180MP0000569_abnormal_digit_pigmentation0.71316247
181MP0003137_abnormal_impulse_conducting0.69013791
182MP0005167_abnormal_blood-brain_barrier0.68422437
183MP0003300_gastrointestinal_ulcer0.67142925
184MP0008874_decreased_physiological_sensi0.66706634
185MP0004742_abnormal_vestibular_system0.66258668
186MP0004142_abnormal_muscle_tone0.65353660

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)7.45823347
2Bony spicule pigmentary retinopathy (HP:0007737)6.07497032
3Central scotoma (HP:0000603)5.79367196
4Premature rupture of membranes (HP:0001788)4.91502161
5Abnormal rod and cone electroretinograms (HP:0008323)4.87688779
6Pigmentary retinal degeneration (HP:0001146)4.87676133
7Scotoma (HP:0000575)4.80779298
8Action tremor (HP:0002345)4.77982684
9Chorioretinal atrophy (HP:0000533)4.77123583
10Absent rod-and cone-mediated responses on ERG (HP:0007688)4.76860181
11Abnormality of macular pigmentation (HP:0008002)4.74532935
12Protrusio acetabuli (HP:0003179)4.22893512
13Dysmetric saccades (HP:0000641)4.19988022
14Dyschromatopsia (HP:0007641)4.16053569
15Abnormality of the lower motor neuron (HP:0002366)3.92290404
16Progressive cerebellar ataxia (HP:0002073)3.76195372
17Visual hallucinations (HP:0002367)3.70095550
18Abolished electroretinogram (ERG) (HP:0000550)3.69319059
19Pendular nystagmus (HP:0012043)3.61714622
20Dysdiadochokinesis (HP:0002075)3.44511477
21Posterior subcapsular cataract (HP:0007787)3.43868504
22Choroideremia (HP:0001139)3.20146788
23Decreased central vision (HP:0007663)3.14813423
24Ankle contracture (HP:0006466)3.13441070
25Ulnar bowing (HP:0003031)3.11880020
26Gaze-evoked nystagmus (HP:0000640)3.10479580
27Type II diabetes mellitus (HP:0005978)3.09827729
28Myokymia (HP:0002411)3.06406635
29Attenuation of retinal blood vessels (HP:0007843)3.01425867
30Spinal rigidity (HP:0003306)3.01232442
31Scanning speech (HP:0002168)2.97514036
32Macular degeneration (HP:0000608)2.96966929
33Hemiplegia (HP:0002301)2.94997875
34Type 1 muscle fiber predominance (HP:0003803)2.94717726
35Intention tremor (HP:0002080)2.90317460
36Impaired smooth pursuit (HP:0007772)2.82279898
37Focal seizures (HP:0007359)2.81434122
38Cone-rod dystrophy (HP:0000548)2.79762206
39Abnormality of ocular smooth pursuit (HP:0000617)2.79679451
40Hand muscle atrophy (HP:0009130)2.74045891
41Increased connective tissue (HP:0009025)2.72652254
42Selective tooth agenesis (HP:0001592)2.68774170
43Upper limb amyotrophy (HP:0009129)2.67912963
44Distal upper limb amyotrophy (HP:0007149)2.67912963
45Vertebral compression fractures (HP:0002953)2.66723951
46Truncal ataxia (HP:0002078)2.60882782
47Photophobia (HP:0000613)2.60652235
48Decreased electroretinogram (ERG) amplitude (HP:0000654)2.58358986
49Trismus (HP:0000211)2.56912693
50Progressive muscle weakness (HP:0003323)2.55361432
51Horizontal nystagmus (HP:0000666)2.55011482
52Distal lower limb amyotrophy (HP:0008944)2.52129466
53Short nail (HP:0001799)2.51575854
54Vitreoretinal degeneration (HP:0000655)2.51427180
55Subcapsular cataract (HP:0000523)2.50048431
56Osteolytic defects of the hand bones (HP:0009699)2.47229010
57Osteolytic defects of the phalanges of the hand (HP:0009771)2.47229010
58Keratoconus (HP:0000563)2.46180319
59Increased corneal curvature (HP:0100692)2.46180319
60Postural tremor (HP:0002174)2.46058437
61Atonic seizures (HP:0010819)2.43457402
62Status epilepticus (HP:0002133)2.42414217
63Ventricular fibrillation (HP:0001663)2.42163796
64Mildly elevated creatine phosphokinase (HP:0008180)2.39987050
65Focal motor seizures (HP:0011153)2.38454188
66Tetraplegia (HP:0002445)2.37648587
67Dysmetria (HP:0001310)2.36285890
68Retinal atrophy (HP:0001105)2.35387728
69Abnormality of the distal phalanges of the toes (HP:0010182)2.34565827
70Genetic anticipation (HP:0003743)2.33623598
71Bladder diverticulum (HP:0000015)2.31919875
72Fragile skin (HP:0001030)2.30609550
73Absence seizures (HP:0002121)2.28895824
74Depression (HP:0000716)2.28177531
75Supranuclear gaze palsy (HP:0000605)2.25357171
76Centrally nucleated skeletal muscle fibers (HP:0003687)2.24569089
77Abnormality of the umbilical cord (HP:0010881)2.23430025
78Coronal craniosynostosis (HP:0004440)2.22293335
79Increased variability in muscle fiber diameter (HP:0003557)2.21636465
80Abnormality of skeletal muscle fiber size (HP:0012084)2.20293850
81Nemaline bodies (HP:0003798)2.19931292
82Constricted visual fields (HP:0001133)2.18539543
83Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.18454909
84Distal lower limb muscle weakness (HP:0009053)2.16662091
85Febrile seizures (HP:0002373)2.15997060
86Epileptic encephalopathy (HP:0200134)2.15239207
87Bundle branch block (HP:0011710)2.12867979
88Back pain (HP:0003418)2.11305998
89Wormian bones (HP:0002645)2.09316150
90Atrophic scars (HP:0001075)2.09251985
91Impaired social interactions (HP:0000735)2.08899724
92Abnormal social behavior (HP:0012433)2.08899724
93Elbow flexion contracture (HP:0002987)2.05732736
94Muscle fiber inclusion bodies (HP:0100299)2.05622727
95Lower limb amyotrophy (HP:0007210)2.03609778
96Generalized amyotrophy (HP:0003700)2.02772925
97Abnormality of the Achilles tendon (HP:0005109)2.02474370
98Myopathic facies (HP:0002058)2.02390879
99Breech presentation (HP:0001623)2.02097039
100Achilles tendon contracture (HP:0001771)2.01687112
101Postural instability (HP:0002172)2.01636241
102Abnormality of dentin (HP:0010299)2.01437887
103Ankyloglossia (HP:0010296)1.99870146
104Annular pancreas (HP:0001734)1.99643931
105Overriding aorta (HP:0002623)1.99133103
106Abnormality of saccadic eye movements (HP:0000570)1.99010098
107Natal tooth (HP:0000695)1.97632970
108Insomnia (HP:0100785)1.96916235
109Abnormality of the calcaneus (HP:0008364)1.94638739
110Cervical subluxation (HP:0003308)1.93727385
111Disproportionate tall stature (HP:0001519)1.92896751
112Poor eye contact (HP:0000817)1.91407804
113Cerebral aneurysm (HP:0004944)1.91123356
114Retinitis pigmentosa (HP:0000510)1.90336762
115Vascular tortuosity (HP:0004948)1.89947828
116Renal duplication (HP:0000075)1.89763081
117Progressive visual loss (HP:0000529)1.89309703
118Deviation of the thumb (HP:0009603)1.88615750
119Right ventricular cardiomyopathy (HP:0011663)1.87723059
120Broad metatarsal (HP:0001783)1.86388231
121Advanced eruption of teeth (HP:0006288)1.86179131
122Spinal cord compression (HP:0002176)1.85954352
123Abnormality of the acetabulum (HP:0003170)1.83580258
124Arterial tortuosity (HP:0005116)1.83414177
125Blue sclerae (HP:0000592)1.82618560
126Abnormality of oral frenula (HP:0000190)1.82514182
127Turricephaly (HP:0000262)1.81906728
128Soft skin (HP:0000977)1.81363700
129Severe visual impairment (HP:0001141)1.81048511
130Abnormality of the distal phalanx of the thumb (HP:0009617)1.80831447
131Hemiparesis (HP:0001269)1.80056735
132Asymmetry of the thorax (HP:0001555)1.79751535
133Genu recurvatum (HP:0002816)1.79039824
134Pointed chin (HP:0000307)1.78529851
135Dialeptic seizures (HP:0011146)1.78467294
136Deep venous thrombosis (HP:0002625)1.77195515
137Pterygium (HP:0001059)1.77050253
138Generalized tonic-clonic seizures (HP:0002069)1.76444415
139Abnormality of the fetal cardiovascular system (HP:0010948)1.76164343
140Abnormal umbilical cord blood vessels (HP:0011403)1.76164343
141Single umbilical artery (HP:0001195)1.76164343
142Aortic aneurysm (HP:0004942)1.75949248
143Difficulty running (HP:0009046)1.75909145
144Exercise-induced myalgia (HP:0003738)1.75536807
145Macroorchidism (HP:0000053)1.75122017
146Shallow orbits (HP:0000586)1.75040842
147Arnold-Chiari malformation (HP:0002308)1.74245221
148Broad-based gait (HP:0002136)1.73063795
149Limb-girdle muscle atrophy (HP:0003797)1.72461779
150Termporal pattern (HP:0011008)1.71826645
151Insidious onset (HP:0003587)1.71826645
152Bowel diverticulosis (HP:0005222)1.71560763
153Neuronal loss in central nervous system (HP:0002529)1.71323524
154Proximal placement of thumb (HP:0009623)1.71288878
155Aortic dissection (HP:0002647)1.70737189
156Abnormality of the phalanges of the hallux (HP:0010057)1.70578205
157Reduced subcutaneous adipose tissue (HP:0003758)1.70447020
158Impaired vibration sensation in the lower limbs (HP:0002166)1.69728928
159Limb ataxia (HP:0002070)1.69383805
160Flat acetabular roof (HP:0003180)1.69375834
161Increased nuchal translucency (HP:0010880)1.69155299
162Calcaneovalgus deformity (HP:0001848)1.68033790
163Hyperacusis (HP:0010780)1.68000673
164Gait ataxia (HP:0002066)1.67527430
165Ragged-red muscle fibers (HP:0003200)1.67081264
166Abnormality of the corticospinal tract (HP:0002492)1.66711166
167Mitral regurgitation (HP:0001653)1.65248529
168Urinary bladder sphincter dysfunction (HP:0002839)1.63381776
169Limb-girdle muscle weakness (HP:0003325)1.63345136
170Spastic gait (HP:0002064)1.63024165
171Abnormality of carpal bone ossification (HP:0006257)1.63006038
172Mitral valve prolapse (HP:0001634)1.62950216
173Elfin facies (HP:0004428)1.62715936
174Facial cleft (HP:0002006)1.62395666
175Myotonia (HP:0002486)1.62088744
176Difficulty climbing stairs (HP:0003551)1.61900827
177Abnormal ossification of hand bones (HP:0005921)1.61720240
178Spastic diplegia (HP:0001264)1.61462952
179Cerebral inclusion bodies (HP:0100314)1.61331664
180Delayed cranial suture closure (HP:0000270)1.61153036
181Biconcave vertebral bodies (HP:0004586)1.60899752
182Microglossia (HP:0000171)1.60714974
183Abnormality of binocular vision (HP:0011514)1.60655808
184Diplopia (HP:0000651)1.60655808
185Slow progression (HP:0003677)1.60494232
186Bowed forearm bones (HP:0003956)1.60386219
187Bowing of the arm (HP:0006488)1.60386219
188Lower limb asymmetry (HP:0100559)1.59618576
189Hyperextensible skin (HP:0000974)1.59181789
190Nonimmune hydrops fetalis (HP:0001790)1.59133603
191Abnormal delivery (HP:0001787)1.58759457

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK13.68249548
2SMG13.11861765
3TRIB32.75008934
4EPHA22.71812861
5MAP3K92.70165548
6BUB12.44493986
7STK382.42557784
8TTK2.34741626
9PAK62.33652884
10CAMKK12.32014388
11CAMKK22.25822488
12PRKD32.24243362
13MST1R2.20378636
14CDC72.19961436
15PBK2.16348870
16WNK12.12692057
17GRK11.92159618
18KSR21.88904431
19NME21.84857475
20NTRK31.84446570
21PKN21.80944094
22MAP3K41.70987057
23ICK1.70671733
24CAMK1G1.67354252
25IRAK31.65279404
26PTK61.63993860
27MET1.60983237
28MINK11.58471511
29PINK11.57747841
30SCYL21.56880237
31NEK11.49713688
32RET1.49425059
33TSSK61.47882223
34MAP2K41.47329288
35DAPK21.46939542
36TESK11.44506075
37SRPK11.42676403
38EEF2K1.36238608
39PRKCH1.35133006
40NTRK11.31695328
41LIMK11.23331421
42CHEK21.23080669
43ALK1.22126669
44TYRO31.21174101
45CDK71.19559928
46PDK41.17787432
47PDK31.17787432
48EPHB11.17705551
49PRPF4B1.16493002
50ARAF1.15704743
51LMTK21.12901714
52RPS6KB21.12210585
53TTN1.11966232
54CAMK1D1.11891611
55SGK31.11882094
56ERBB41.10053714
57PAK21.08149499
58PNCK1.07051825
59PDGFRA1.06940390
60SIK11.06112696
61SGK2231.06027423
62SGK4941.06027423
63MAP3K101.02882400
64MAP3K81.02466107
65PTK21.01816127
66MYLK1.00447625
67MAP3K20.98647696
68SIK20.98008269
69NEK20.97730195
70STK110.97463487
71EIF2AK10.94974269
72NTRK20.94303616
73CDK80.94107204
74LATS20.93863617
75NEK90.93241742
76BMX0.92521459
77PHKG20.92520814
78PHKG10.92520814
79BRAF0.92121493
80AURKA0.90663080
81BRSK10.90027282
82TAOK10.89801317
83AURKB0.89799684
84DMPK0.88705106
85PDK10.86138393
86PLK10.86136129
87ERN10.84865256
88FGFR40.83024911
89MAP3K70.82725022
90AKT20.81666506
91CDK50.81653563
92CDK40.79343993
93VRK20.78411537
94WEE10.78368396
95CHEK10.78337000
96LATS10.77183242
97ILK0.77179343
98PDPK10.76865008
99FER0.76548619
100SGK20.75355920
101PRKCG0.75282336
102PRKAA10.74380242
103KSR10.74376941
104TESK20.74246174
105STK40.74197882
106PTK2B0.72627035
107CAMK10.72038909
108CAMK40.71087739
109EPHB20.70715409
110CDK60.69678649
111CDC42BPA0.67474420
112PAK30.66257030
113HIPK20.64334385
114CDK150.64258516
115WNK40.63040341
116MTOR0.62187758
117CDK140.59206887
118MARK10.58521135
119PRKD10.57577698
120DDR20.57509637
121RPS6KA30.57140651
122GRK50.56314692
123MELK0.56220699
124CDK180.55907149
125FGFR20.55837339
126MARK20.54894445
127PRKD20.53885719
128ATR0.53231636
129ROCK20.52607380
130ERBB20.52446246
131CDK11A0.52132631
132CAMK2D0.51537120
133MOS0.51482309
134CDK120.51290301
135TAF10.51258620
136PLK30.51198520
137PRKCZ0.51115595
138SGK10.49946083
139TAOK20.49806636
140STK30.49752110
141OXSR10.49557614
142MAP3K10.48860644
143PRKG20.48637959
144ABL20.48267220
145MAPK120.48046830
146PAK10.47893691
147PDK20.47868116
148OBSCN0.47039615
149MAP3K30.46574594
150BRSK20.45918962
151PDGFRB0.45695425
152CDK190.45221517
153FGFR10.44968497
154FYN0.44603336
155PAK40.44600279
156CDK10.43773063
157DYRK1B0.43095149
158SRC0.41066411
159CDK20.39839949
160STK240.39787666
161RPS6KA20.39396257
162MAPK110.36926450
163KDR0.36415541
164RAF10.36086875
165CLK10.34710529

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047445.72700708
2DNA replication_Homo sapiens_hsa030303.20446365
3Nitrogen metabolism_Homo sapiens_hsa009102.66600639
4Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.59977505
5Synaptic vesicle cycle_Homo sapiens_hsa047212.31960285
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.26895754
7Nicotine addiction_Homo sapiens_hsa050332.16104742
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.13272082
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.98193627
10Cell cycle_Homo sapiens_hsa041101.96419945
11Mismatch repair_Homo sapiens_hsa034301.96122978
12GABAergic synapse_Homo sapiens_hsa047271.94339900
13Glutamatergic synapse_Homo sapiens_hsa047241.92907477
14Long-term potentiation_Homo sapiens_hsa047201.84117635
15Circadian entrainment_Homo sapiens_hsa047131.80416305
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.79560990
17Pentose phosphate pathway_Homo sapiens_hsa000301.70199137
18Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.69244134
19Bladder cancer_Homo sapiens_hsa052191.61401241
20Thyroid cancer_Homo sapiens_hsa052161.60525841
21Base excision repair_Homo sapiens_hsa034101.60225098
22Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.58014067
23Salivary secretion_Homo sapiens_hsa049701.55073052
24Sulfur relay system_Homo sapiens_hsa041221.54765042
25Olfactory transduction_Homo sapiens_hsa047401.54371407
26Adherens junction_Homo sapiens_hsa045201.53868072
27Morphine addiction_Homo sapiens_hsa050321.50826605
28ECM-receptor interaction_Homo sapiens_hsa045121.49764344
29Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.48375455
30Aldosterone synthesis and secretion_Homo sapiens_hsa049251.45473265
31Bile secretion_Homo sapiens_hsa049761.45421518
32Arginine biosynthesis_Homo sapiens_hsa002201.44184871
33Vitamin B6 metabolism_Homo sapiens_hsa007501.43124310
34Gastric acid secretion_Homo sapiens_hsa049711.42144308
35Galactose metabolism_Homo sapiens_hsa000521.39081205
36Nucleotide excision repair_Homo sapiens_hsa034201.38796465
37RNA transport_Homo sapiens_hsa030131.37346590
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.34982723
39Long-term depression_Homo sapiens_hsa047301.34962633
40Insulin secretion_Homo sapiens_hsa049111.32967553
41Dopaminergic synapse_Homo sapiens_hsa047281.31660257
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.30997048
43Cholinergic synapse_Homo sapiens_hsa047251.30055851
44One carbon pool by folate_Homo sapiens_hsa006701.26046741
45Hippo signaling pathway_Homo sapiens_hsa043901.23628265
46Spliceosome_Homo sapiens_hsa030401.22213054
47Amphetamine addiction_Homo sapiens_hsa050311.19166369
48Small cell lung cancer_Homo sapiens_hsa052221.19038792
49Chronic myeloid leukemia_Homo sapiens_hsa052201.17942481
50Oxytocin signaling pathway_Homo sapiens_hsa049211.16462012
51Type II diabetes mellitus_Homo sapiens_hsa049301.16061542
52N-Glycan biosynthesis_Homo sapiens_hsa005101.15713725
53Pyrimidine metabolism_Homo sapiens_hsa002401.15305811
54Taste transduction_Homo sapiens_hsa047421.13791330
55MicroRNAs in cancer_Homo sapiens_hsa052061.10126716
56Cyanoamino acid metabolism_Homo sapiens_hsa004601.09858542
57mRNA surveillance pathway_Homo sapiens_hsa030151.09697788
58Carbohydrate digestion and absorption_Homo sapiens_hsa049731.08979101
59Folate biosynthesis_Homo sapiens_hsa007901.07180006
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.06047510
61Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.05976243
62Renin secretion_Homo sapiens_hsa049241.03122649
63Non-homologous end-joining_Homo sapiens_hsa034501.02900620
64Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.02705861
65Cysteine and methionine metabolism_Homo sapiens_hsa002701.01792179
66Basal cell carcinoma_Homo sapiens_hsa052171.01574432
67Thyroid hormone synthesis_Homo sapiens_hsa049181.01046255
68Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00407047
692-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.00113424
70Estrogen signaling pathway_Homo sapiens_hsa049150.99432676
71cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99401868
72Tight junction_Homo sapiens_hsa045300.98789495
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.95955918
74Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94718481
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94391992
76mTOR signaling pathway_Homo sapiens_hsa041500.94379224
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.94309238
78GnRH signaling pathway_Homo sapiens_hsa049120.93169899
79Arginine and proline metabolism_Homo sapiens_hsa003300.91518327
80Pancreatic secretion_Homo sapiens_hsa049720.90781459
81Dilated cardiomyopathy_Homo sapiens_hsa054140.88636695
82cAMP signaling pathway_Homo sapiens_hsa040240.87704351
83Circadian rhythm_Homo sapiens_hsa047100.85983175
84Inositol phosphate metabolism_Homo sapiens_hsa005620.83355283
85Gap junction_Homo sapiens_hsa045400.82562521
86Pancreatic cancer_Homo sapiens_hsa052120.82546067
87Glucagon signaling pathway_Homo sapiens_hsa049220.82019914
88Selenocompound metabolism_Homo sapiens_hsa004500.78585343
89Vibrio cholerae infection_Homo sapiens_hsa051100.78262031
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.78125319
91Endometrial cancer_Homo sapiens_hsa052130.77515915
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.77008672
93Protein digestion and absorption_Homo sapiens_hsa049740.76288466
94Calcium signaling pathway_Homo sapiens_hsa040200.75842608
95Prostate cancer_Homo sapiens_hsa052150.75214538
96TGF-beta signaling pathway_Homo sapiens_hsa043500.74579534
97Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.74443744
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73500956
99Glycerolipid metabolism_Homo sapiens_hsa005610.72960549
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.72844423
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72320663
102p53 signaling pathway_Homo sapiens_hsa041150.71227472
103Fatty acid biosynthesis_Homo sapiens_hsa000610.71034894
104Glioma_Homo sapiens_hsa052140.70008873
105Dorso-ventral axis formation_Homo sapiens_hsa043200.69820137
106Cocaine addiction_Homo sapiens_hsa050300.69132817
107Ribosome_Homo sapiens_hsa030100.69079161
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68697982
109Fatty acid elongation_Homo sapiens_hsa000620.68684291
110Phenylalanine metabolism_Homo sapiens_hsa003600.68296901
111ABC transporters_Homo sapiens_hsa020100.67450001
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67422260
113Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.67320352
114Melanoma_Homo sapiens_hsa052180.66718388
115Lysine degradation_Homo sapiens_hsa003100.66124789
116Prion diseases_Homo sapiens_hsa050200.65922590
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65800158
118Biosynthesis of amino acids_Homo sapiens_hsa012300.64272781
119Wnt signaling pathway_Homo sapiens_hsa043100.63716245
120Vascular smooth muscle contraction_Homo sapiens_hsa042700.62980979
121Renin-angiotensin system_Homo sapiens_hsa046140.62924344
122Sulfur metabolism_Homo sapiens_hsa009200.62789193
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61834768
124VEGF signaling pathway_Homo sapiens_hsa043700.61727802
125Hedgehog signaling pathway_Homo sapiens_hsa043400.61015923
126PPAR signaling pathway_Homo sapiens_hsa033200.58541806
127Glutathione metabolism_Homo sapiens_hsa004800.58008316
128Butanoate metabolism_Homo sapiens_hsa006500.57744793
129Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.57389262
130Serotonergic synapse_Homo sapiens_hsa047260.57118763
131Primary bile acid biosynthesis_Homo sapiens_hsa001200.56782865
132Insulin resistance_Homo sapiens_hsa049310.56307168
133Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55976018
134Fatty acid degradation_Homo sapiens_hsa000710.55832210
135Pathways in cancer_Homo sapiens_hsa052000.54794948
136AMPK signaling pathway_Homo sapiens_hsa041520.54536302
137Cardiac muscle contraction_Homo sapiens_hsa042600.54416020
138RNA polymerase_Homo sapiens_hsa030200.54273164
139Fatty acid metabolism_Homo sapiens_hsa012120.54178475
140Proteasome_Homo sapiens_hsa030500.54141021
141Adipocytokine signaling pathway_Homo sapiens_hsa049200.53440285
142Colorectal cancer_Homo sapiens_hsa052100.53231797
143Renal cell carcinoma_Homo sapiens_hsa052110.52626536
144Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51787243
145Pyruvate metabolism_Homo sapiens_hsa006200.51469066
146Glycerophospholipid metabolism_Homo sapiens_hsa005640.51220165
147Viral carcinogenesis_Homo sapiens_hsa052030.51108732
148Oocyte meiosis_Homo sapiens_hsa041140.50386468
149Carbon metabolism_Homo sapiens_hsa012000.49952574
150Other glycan degradation_Homo sapiens_hsa005110.49805437
151Purine metabolism_Homo sapiens_hsa002300.49398438
152Choline metabolism in cancer_Homo sapiens_hsa052310.49115666
153Proteoglycans in cancer_Homo sapiens_hsa052050.48387968
154Melanogenesis_Homo sapiens_hsa049160.47525825
155Homologous recombination_Homo sapiens_hsa034400.47254849
156Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.46583224
157Insulin signaling pathway_Homo sapiens_hsa049100.46362906
158Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46129384
159Sphingolipid metabolism_Homo sapiens_hsa006000.44734661
160Endocytosis_Homo sapiens_hsa041440.44191128
161Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44003020
162MAPK signaling pathway_Homo sapiens_hsa040100.41360754
163Mineral absorption_Homo sapiens_hsa049780.41060816
164Neurotrophin signaling pathway_Homo sapiens_hsa047220.40130016
165Fructose and mannose metabolism_Homo sapiens_hsa000510.39324559
166ErbB signaling pathway_Homo sapiens_hsa040120.38560761
167Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.37981269
168Non-small cell lung cancer_Homo sapiens_hsa052230.35514632
169Focal adhesion_Homo sapiens_hsa045100.35047915

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