ICOS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)7.86020713
2negative thymic T cell selection (GO:0045060)7.78437275
3positive regulation of gamma-delta T cell activation (GO:0046645)6.89666221
4response to interleukin-15 (GO:0070672)6.86206849
5cellular response to interleukin-15 (GO:0071350)6.82003743
6regulation of isotype switching to IgG isotypes (GO:0048302)6.70793299
7positive thymic T cell selection (GO:0045059)6.58446956
8thymic T cell selection (GO:0045061)6.56065585
9negative regulation of cell killing (GO:0031342)6.37584858
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.37584858
11positive regulation of interleukin-2 biosynthetic process (GO:0045086)6.34160855
12T cell selection (GO:0045058)6.14590644
13positive T cell selection (GO:0043368)6.02633617
14regulation of gamma-delta T cell differentiation (GO:0045586)6.01682750
15interferon-gamma production (GO:0032609)5.98224375
16regulation of gamma-delta T cell activation (GO:0046643)5.58716374
17leukocyte aggregation (GO:0070486)5.49917638
18regulation of T cell tolerance induction (GO:0002664)5.47999688
19antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.37614915
20antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.37614915
21positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.14799122
22T cell receptor signaling pathway (GO:0050852)5.13848508
23* tolerance induction (GO:0002507)5.13333699
24* lymphocyte costimulation (GO:0031294)5.11585772
25* T cell costimulation (GO:0031295)5.08237645
26T cell migration (GO:0072678)4.95487535
27regulation of interleukin-2 biosynthetic process (GO:0045076)4.91679446
28positive regulation of T cell differentiation in thymus (GO:0033089)4.84672589
29T-helper cell differentiation (GO:0042093)4.56790902
30CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)4.56790902
31antigen processing and presentation of endogenous antigen (GO:0019883)4.55717294
32positive regulation of tolerance induction (GO:0002645)4.44465327
33regulation of chronic inflammatory response (GO:0002676)4.40341814
34regulation of isotype switching (GO:0045191)4.36927404
35regulation of regulatory T cell differentiation (GO:0045589)4.36328733
36antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.35688842
37positive regulation of isotype switching (GO:0045830)4.27533643
38antigen receptor-mediated signaling pathway (GO:0050851)4.26853522
39regulation of alpha-beta T cell proliferation (GO:0046640)4.21455183
40positive regulation of interleukin-2 production (GO:0032743)4.15002153
41T cell differentiation involved in immune response (GO:0002292)4.13450456
42alpha-beta T cell differentiation involved in immune response (GO:0002293)4.13450456
43alpha-beta T cell activation involved in immune response (GO:0002287)4.13450456
44positive regulation of alpha-beta T cell proliferation (GO:0046641)4.09592740
45positive regulation of natural killer cell mediated immunity (GO:0002717)4.06769145
46positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.06769145
47regulation of B cell receptor signaling pathway (GO:0050855)4.02932018
48regulation of tolerance induction (GO:0002643)4.01861965
49regulation of immunoglobulin production (GO:0002637)4.01762798
50regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.00497442
51regulation of natural killer cell mediated immunity (GO:0002715)4.00497442
52positive regulation of uterine smooth muscle contraction (GO:0070474)3.99116822
53alpha-beta T cell differentiation (GO:0046632)3.93029637
54positive regulation of immunoglobulin production (GO:0002639)3.88631700
55alpha-beta T cell activation (GO:0046631)3.85639433
56negative regulation of T cell apoptotic process (GO:0070233)3.84514257
57negative regulation of T cell mediated immunity (GO:0002710)3.82737670
58regulation of T cell receptor signaling pathway (GO:0050856)3.80333956
59mucosal-associated lymphoid tissue development (GO:0048537)3.80310665
60Peyers patch development (GO:0048541)3.80310665
61regulation of immunoglobulin mediated immune response (GO:0002889)3.78454410
62regulation of leukocyte mediated cytotoxicity (GO:0001910)3.76029073
63positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.75101139
64positive regulation of immunoglobulin mediated immune response (GO:0002891)3.74480749
65positive regulation of B cell mediated immunity (GO:0002714)3.74480749
66antigen processing and presentation via MHC class Ib (GO:0002475)3.74028914
67regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.69959227
68JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.68277521
69positive regulation of DNA recombination (GO:0045911)3.67744069
70regulation of response to interferon-gamma (GO:0060330)3.67591893
71T cell differentiation (GO:0030217)3.67242468
72regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.66667281
73regulation of B cell mediated immunity (GO:0002712)3.64453754
74CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.61954288
75regulation of memory T cell differentiation (GO:0043380)3.60051726
76RNA destabilization (GO:0050779)3.56544546
77regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.56272310
78regulation of immunoglobulin secretion (GO:0051023)3.53954914
79regulation of cell killing (GO:0031341)3.52714107
80regulation of interleukin-12 biosynthetic process (GO:0045075)3.50044188
81negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.48772253
82regulation of T cell mediated cytotoxicity (GO:0001914)3.46422527
83NIK/NF-kappaB signaling (GO:0038061)3.45635040
84T cell activation involved in immune response (GO:0002286)3.45533368
85activated T cell proliferation (GO:0050798)3.44146466
86positive regulation of cell killing (GO:0031343)3.43291724
87CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.40263317
88tyrosine phosphorylation of STAT protein (GO:0007260)3.38618368
89B cell receptor signaling pathway (GO:0050853)3.36836933
90positive regulation of T cell mediated immunity (GO:0002711)3.36138438
91positive regulation of defense response to virus by host (GO:0002230)3.34925758
92regulation of interleukin-2 production (GO:0032663)3.34848818
93zinc ion homeostasis (GO:0055069)3.31938769
94mature B cell differentiation involved in immune response (GO:0002313)3.30565146
95positive regulation of alpha-beta T cell activation (GO:0046635)3.30562535
96T cell activation (GO:0042110)3.27720899
97tumor necrosis factor-mediated signaling pathway (GO:0033209)3.26378365
98natural killer cell activation (GO:0030101)3.25714818
99positive regulation of T cell differentiation (GO:0045582)3.25709442
100regulation of defense response to virus by virus (GO:0050690)3.24392729
101negative regulation of interleukin-12 production (GO:0032695)3.24294019
102lymph node development (GO:0048535)3.23068159
103regulation of alpha-beta T cell activation (GO:0046634)3.20427310
104positive regulation of granulocyte differentiation (GO:0030854)3.20300965
105myeloid dendritic cell differentiation (GO:0043011)3.18831692
106positive regulation of humoral immune response (GO:0002922)3.18789672
107regulation of lymphocyte mediated immunity (GO:0002706)3.18526987
108negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.16804081
109mast cell activation (GO:0045576)3.15607942
110leukocyte cell-cell adhesion (GO:0007159)3.15203049
111positive regulation of T cell mediated cytotoxicity (GO:0001916)3.13553481
112CD4-positive, alpha-beta T cell activation (GO:0035710)3.13436320
113positive regulation of lymphocyte mediated immunity (GO:0002708)3.12821379
114regulation of type I interferon-mediated signaling pathway (GO:0060338)3.12043283
115positive regulation of alpha-beta T cell differentiation (GO:0046638)3.11560981
116sequestering of actin monomers (GO:0042989)3.11412329
117negative regulation of lymphocyte mediated immunity (GO:0002707)3.10790515
118regulation of T cell mediated immunity (GO:0002709)3.10293525
119positive regulation of lymphocyte differentiation (GO:0045621)3.10274226
120regulation of T cell differentiation in thymus (GO:0033081)3.09918052
121positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.09645094
122cellular zinc ion homeostasis (GO:0006882)3.08292411
123negative regulation of innate immune response (GO:0045824)3.07896859
124regulation of alpha-beta T cell differentiation (GO:0046637)3.05233277
125protein K11-linked deubiquitination (GO:0035871)3.02563789
126negative regulation of leukocyte mediated immunity (GO:0002704)3.01862274
127positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.01271782
128mast cell activation involved in immune response (GO:0002279)2.99436013

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXP3_17237761_ChIP-ChIP_TREG_Mouse8.73294307
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human7.04705731
3* STAT3_20064451_ChIP-Seq_CD4+T_Mouse4.57623020
4* STAT4_19710469_ChIP-ChIP_TH1__Mouse4.01685550
5RUNX_20019798_ChIP-Seq_JUKART_Human3.99050241
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.90167475
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.78828513
8FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.55179228
9* MYB_26560356_Chip-Seq_TH2_Human3.52935946
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.50587234
11MYC_22102868_ChIP-Seq_BL_Human3.22521739
12BP1_19119308_ChIP-ChIP_Hs578T_Human3.22414485
13MAF_26560356_Chip-Seq_TH1_Human3.16203592
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.04645521
15MYB_26560356_Chip-Seq_TH1_Human2.94623042
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.88026415
17UTX_26944678_Chip-Seq_JUKART_Human2.67926782
18E2F7_22180533_ChIP-Seq_HELA_Human2.53622279
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.49047265
20IRF8_21731497_ChIP-ChIP_J774_Mouse2.30726874
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.28949006
22MAF_26560356_Chip-Seq_TH2_Human2.27499713
23NOTCH1_21737748_ChIP-Seq_TLL_Human2.21682828
24KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.13002251
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.12440200
26GATA3_27048872_Chip-Seq_THYMUS_Human2.11365714
27VDR_21846776_ChIP-Seq_THP-1_Human2.02462428
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.98180607
29NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.95952162
30RUNX1_22412390_ChIP-Seq_EML_Mouse1.95399905
31TCF7_22412390_ChIP-Seq_EML_Mouse1.94219428
32SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.92065062
33* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.80508586
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.80305338
35MYB_21317192_ChIP-Seq_ERMYB_Mouse1.79538951
36IRF8_27001747_Chip-Seq_BMDM_Mouse1.77004045
37KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.71755604
38SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.71024040
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.69602667
40SPI1_23547873_ChIP-Seq_NB4_Human1.67531652
41E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.65573930
42KDM2B_26808549_Chip-Seq_DND41_Human1.64668147
43ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.58155203
44VDR_24763502_ChIP-Seq_THP-1_Human1.58005059
45BRD4_27068464_Chip-Seq_AML-cells_Mouse1.47297303
46* FLI1_27457419_Chip-Seq_LIVER_Mouse1.46622329
47* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.42660580
48SCL_19346495_ChIP-Seq_HPC-7_Human1.40569568
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.33958072
50* PU_27001747_Chip-Seq_BMDM_Mouse1.31973215
51* GATA3_26560356_Chip-Seq_TH2_Human1.31557925
52MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.29112464
53KDM2B_26808549_Chip-Seq_SUP-B15_Human1.28550697
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25616172
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.22370911
56GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21790173
57SPI1_23127762_ChIP-Seq_K562_Human1.21421632
58CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.21365670
59KDM2B_26808549_Chip-Seq_JURKAT_Human1.20318419
60TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.18238997
61NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.17059961
62ELF1_17652178_ChIP-ChIP_JURKAT_Human1.13799514
63GATA3_26560356_Chip-Seq_TH1_Human1.12878768
64CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07033155
65* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.06991343
66ELK3_25401928_ChIP-Seq_HUVEC_Human1.02390519
67TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01333694
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01191261
69PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00335314
70NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97700788
71CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96873569
72IRF1_19129219_ChIP-ChIP_H3396_Human0.96077209
73* VDR_23849224_ChIP-Seq_CD4+_Human0.95826983
74CIITA_25753668_ChIP-Seq_RAJI_Human0.95398915
75EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.94585545
76GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93421585
77BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.91877447
78STAT1_20625510_ChIP-Seq_HELA_Human0.88918541
79GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.88830038
80CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88429967
81PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86072999
82SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.85536844
83EGR1_19032775_ChIP-ChIP_M12_Human0.85224552
84VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.84066329
85SMRT_27268052_Chip-Seq_Bcells_Human0.82757882
86RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82558556
87P300_27268052_Chip-Seq_Bcells_Human0.82436337
88RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.81517824
89EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.81424755
90LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.81127693
91PU.1_20513432_ChIP-Seq_Bcells_Mouse0.79592337
92FOXM1_23109430_ChIP-Seq_U2OS_Human0.78829075
93BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.78622577
94CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78418383
95THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.78293456
96GATA1_22383799_ChIP-Seq_G1ME_Mouse0.77753765
97VDR_24787735_ChIP-Seq_THP-1_Human0.76504968
98DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.76236434
99BCL6_27268052_Chip-Seq_Bcells_Human0.74877885
100* FOXP3_21729870_ChIP-Seq_TREG_Human0.74821913
101GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74291251
102FOXO3_23340844_ChIP-Seq_DLD1_Human0.73824648
103STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.73411772
104NCOR1_26117541_ChIP-Seq_K562_Human0.73001961
105SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.72558610
106ERG_20887958_ChIP-Seq_HPC-7_Mouse0.72498500
107ELF1_20517297_ChIP-Seq_JURKAT_Human0.71804594
108GATA1_19941827_ChIP-Seq_MEL_Mouse0.70623216
109FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.70126693
110RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.69846891
111BCOR_27268052_Chip-Seq_Bcells_Human0.69417744
112CTCF_21964334_ChIP-Seq_BJAB-B_Human0.68361293
113HOXB4_20404135_ChIP-ChIP_EML_Mouse0.68182080
114EST1_17652178_ChIP-ChIP_JURKAT_Human0.67371821
115* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.67006537
116ETS1_21867929_ChIP-Seq_TH2_Mouse0.66694726
117EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.66635677
118E2F4_17652178_ChIP-ChIP_JURKAT_Human0.66324284
119PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.64628050
120LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.64448600
121FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.64441552
122HIF1A_21447827_ChIP-Seq_MCF-7_Human0.62923999
123GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.61700497
124TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.61137199
125PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.60262165

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology5.42912261
2MP0005671_abnormal_response_to5.21009045
3MP0000685_abnormal_immune_system3.37051369
4MP0001800_abnormal_humoral_immune3.26170013
5MP0001835_abnormal_antigen_presentation3.24204915
6MP0001790_abnormal_immune_system3.24002137
7MP0005387_immune_system_phenotype3.24002137
8MP0003300_gastrointestinal_ulcer3.08331653
9* MP0005000_abnormal_immune_tolerance3.07720353
10MP0009333_abnormal_splenocyte_physiolog3.01575321
11MP0002166_altered_tumor_susceptibility3.00250521
12MP0002723_abnormal_immune_serum2.86768790
13MP0001873_stomach_inflammation2.85554470
14MP0009785_altered_susceptibility_to2.81654955
15MP0003724_increased_susceptibility_to2.77646025
16MP0002420_abnormal_adaptive_immunity2.73645544
17* MP0001819_abnormal_immune_cell2.66774873
18MP0002398_abnormal_bone_marrow2.63681509
19MP0006082_CNS_inflammation2.54216236
20MP0002933_joint_inflammation2.52323294
21MP0002405_respiratory_system_inflammati2.51699341
22MP0010155_abnormal_intestine_physiology2.49786901
23* MP0002452_abnormal_antigen_presenting2.47433056
24MP0002006_tumorigenesis2.47171532
25MP0003436_decreased_susceptibility_to2.45541806
26MP0003303_peritoneal_inflammation2.43318381
27MP0004510_myositis2.41663272
28MP0000703_abnormal_thymus_morphology2.40691396
29* MP0005025_abnormal_response_to2.36385272
30MP0003866_abnormal_defecation2.34469107
31* MP0000716_abnormal_immune_system2.30733225
32MP0004947_skin_inflammation2.19845985
33MP0000569_abnormal_digit_pigmentation2.17707120
34* MP0002722_abnormal_immune_system2.07894157
35MP0000689_abnormal_spleen_morphology1.98735016
36MP0001853_heart_inflammation1.93903044
37MP0002148_abnormal_hypersensitivity_rea1.83850958
38* MP0002429_abnormal_blood_cell1.83752831
39MP0001845_abnormal_inflammatory_respons1.78011893
40MP0002396_abnormal_hematopoietic_system1.75389858
41MP0005310_abnormal_salivary_gland1.72206925
42MP0002419_abnormal_innate_immunity1.71577390
43MP0005408_hypopigmentation1.64448315
44MP0001919_abnormal_reproductive_system1.60845338
45MP0000858_altered_metastatic_potential1.48130147
46MP0003448_altered_tumor_morphology1.36737843
47MP0000490_abnormal_crypts_of1.33904300
48MP0002009_preneoplasia1.29664476
49MP0000465_gastrointestinal_hemorrhage1.28061191
50MP0005464_abnormal_platelet_physiology1.26570250
51MP0001533_abnormal_skeleton_physiology1.26415717
52MP0000371_diluted_coat_color1.25940415
53MP0001851_eye_inflammation1.16551433
54MP0004808_abnormal_hematopoietic_stem1.16244668
55* MP0008469_abnormal_protein_level1.15183475
56MP0003045_fibrosis1.10471274
57MP0001348_abnormal_lacrimal_gland1.09676217
58MP0005174_abnormal_tail_pigmentation1.05285837
59MP0003172_abnormal_lysosome_physiology1.04126933
60MP0010352_gastrointestinal_tract_polyps1.03171309
61MP0000015_abnormal_ear_pigmentation1.03085795
62MP0002998_abnormal_bone_remodeling0.98689638
63MP0004381_abnormal_hair_follicle0.97583568
64MP0002138_abnormal_hepatobiliary_system0.94721634
65MP0001545_abnormal_hematopoietic_system0.94167580
66MP0005397_hematopoietic_system_phenotyp0.94167580
67MP0005076_abnormal_cell_differentiation0.92169892
68MP0002019_abnormal_tumor_incidence0.90981163
69MP0002254_reproductive_system_inflammat0.90168951
70MP0002163_abnormal_gland_morphology0.89905938
71MP0005023_abnormal_wound_healing0.86630912
72MP0008961_abnormal_basal_metabolism0.86044490
73MP0003828_pulmonary_edema0.85729940
74MP0003252_abnormal_bile_duct0.81225746
75MP0009763_increased_sensitivity_to0.77880504
76MP0001501_abnormal_sleep_pattern0.73136733
77MP0004130_abnormal_muscle_cell0.73051831
78MP0001243_abnormal_dermal_layer0.72153277
79MP0005389_reproductive_system_phenotype0.71006226
80MP0001881_abnormal_mammary_gland0.70162892
81MP0002876_abnormal_thyroid_physiology0.68986326
82MP0000604_amyloidosis0.68693857
83MP0001663_abnormal_digestive_system0.68571732
84MP0009765_abnormal_xenobiotic_induced0.67643662
85MP0008007_abnormal_cellular_replicative0.66912858
86MP0000249_abnormal_blood_vessel0.65405154
87MP0009764_decreased_sensitivity_to0.65296712
88MP0008057_abnormal_DNA_replication0.65006340
89MP0003795_abnormal_bone_structure0.64726655
90* MP0000477_abnormal_intestine_morphology0.63560671
91MP0003453_abnormal_keratinocyte_physiol0.61967886
92MP0000343_altered_response_to0.61752624
93MP0000609_abnormal_liver_physiology0.61501197
94MP0001986_abnormal_taste_sensitivity0.60255196
95MP0003787_abnormal_imprinting0.58405212
96MP0002102_abnormal_ear_morphology0.57696428
97MP0001216_abnormal_epidermal_layer0.57304359
98MP0005075_abnormal_melanosome_morpholog0.57168193
99MP0002132_abnormal_respiratory_system0.55899650
100MP0002075_abnormal_coat/hair_pigmentati0.55237509
101MP0008873_increased_physiological_sensi0.53083933
102MP0009840_abnormal_foam_cell0.53057571
103MP0002822_catalepsy0.51221611
104MP0005166_decreased_susceptibility_to0.51080403
105MP0005165_increased_susceptibility_to0.49853354
106MP0002653_abnormal_ependyma_morphology0.49262966
107MP0000367_abnormal_coat/_hair0.47711259
108MP0001765_abnormal_ion_homeostasis0.46916133
109MP0001849_ear_inflammation0.46825021
110MP0003091_abnormal_cell_migration0.46453874
111MP0002277_abnormal_respiratory_mucosa0.45948508
112MP0001502_abnormal_circadian_rhythm0.45422121
113MP0002136_abnormal_kidney_physiology0.45217220
114MP0003077_abnormal_cell_cycle0.45203416
115MP0001191_abnormal_skin_condition0.45101221
116MP0005390_skeleton_phenotype0.44921128
117MP0001119_abnormal_female_reproductive0.43703747
118MP0005379_endocrine/exocrine_gland_phen0.42790789
119MP0010234_abnormal_vibrissa_follicle0.41984266
120MP0000627_abnormal_mammary_gland0.41492994
121MP0008872_abnormal_physiological_respon0.40120543
122MP0009697_abnormal_copulation0.38791696
123MP0009278_abnormal_bone_marrow0.37566807
124MP0000598_abnormal_liver_morphology0.37315564
125MP0002877_abnormal_melanocyte_morpholog0.35813647
126* MP0002693_abnormal_pancreas_physiology0.35698511

Predicted human phenotypes

RankGene SetZ-score
1Optic neuritis (HP:0100653)7.13493368
2Retrobulbar optic neuritis (HP:0100654)7.13493368
3Myositis (HP:0100614)7.02187307
4T lymphocytopenia (HP:0005403)6.74429483
5Abnormality of T cell number (HP:0011839)6.56647593
6Orchitis (HP:0100796)6.32065079
7Severe combined immunodeficiency (HP:0004430)5.77824732
8Elevated erythrocyte sedimentation rate (HP:0003565)5.73431750
9Stomatitis (HP:0010280)5.42193880
10Combined immunodeficiency (HP:0005387)5.12437576
11Keratoconjunctivitis sicca (HP:0001097)4.83793032
12* Abnormality of T cells (HP:0002843)4.63707852
13Recurrent fungal infections (HP:0002841)4.46375973
14Pulmonary infiltrates (HP:0002113)4.44209116
15Hemoptysis (HP:0002105)4.39096701
16Keratoconjunctivitis (HP:0001096)4.38606889
17Eczematoid dermatitis (HP:0000976)4.22338205
18Increased IgM level (HP:0003496)4.11233334
19Chronic diarrhea (HP:0002028)4.08294956
20Arterial thrombosis (HP:0004420)4.08123812
21Panhypogammaglobulinemia (HP:0003139)3.90524813
22Recurrent cutaneous fungal infections (HP:0011370)3.84805899
23Chronic mucocutaneous candidiasis (HP:0002728)3.84805899
24Autoimmune hemolytic anemia (HP:0001890)3.83601206
25Gangrene (HP:0100758)3.76724437
26Nasal polyposis (HP:0100582)3.74945825
27* IgG deficiency (HP:0004315)3.73244203
28Abnormality of eosinophils (HP:0001879)3.70663182
29Joint swelling (HP:0001386)3.65082691
30Pulmonary embolism (HP:0002204)3.63408463
31Gastrointestinal infarctions (HP:0005244)3.62649654
32* Recurrent bronchitis (HP:0002837)3.55703632
33* Vasculitis (HP:0002633)3.50851834
34Chronic otitis media (HP:0000389)3.50332487
35Pustule (HP:0200039)3.47876774
36Encephalitis (HP:0002383)3.46269482
37Recurrent viral infections (HP:0004429)3.43994773
38Abnormality of the fingertips (HP:0001211)3.43810767
39Stomach cancer (HP:0012126)3.42963722
40Thyroiditis (HP:0100646)3.40135264
41Meningitis (HP:0001287)3.31638110
42Abnormal delayed hypersensitivity skin test (HP:0002963)3.30637526
43Leukocytosis (HP:0001974)3.21242678
44Abnormality of the nasal mucosa (HP:0000433)3.13335119
45Anorexia (HP:0002039)3.11195618
46Eosinophilia (HP:0001880)2.98515549
47Abnormality of the prostate (HP:0008775)2.97532563
48Obstructive lung disease (HP:0006536)2.91681907
49Chronic obstructive pulmonary disease (HP:0006510)2.91681907
50* IgM deficiency (HP:0002850)2.85161285
51Hypergammaglobulinemia (HP:0010702)2.84952790
52Ureteral stenosis (HP:0000071)2.82994799
53Increased density of long bones (HP:0006392)2.82297412
54Chest pain (HP:0100749)2.78423848
55* Abnormality of B cell number (HP:0010975)2.77247479
56* Abnormality of T cell physiology (HP:0011840)2.72808298
57Prostate neoplasm (HP:0100787)2.66789101
58Glomerulopathy (HP:0100820)2.66433577
59Polyneuropathy (HP:0001271)2.62657005
60Granulocytopenia (HP:0001913)2.61417205
61* Lymphopenia (HP:0001888)2.60416599
62Adactyly (HP:0009776)2.59515520
63Ureteral obstruction (HP:0006000)2.57331975
64Abnormality of the pleura (HP:0002103)2.57219367
65* Abnormality of cells of the lymphoid lineage (HP:0012140)2.54167339
66Increased IgE level (HP:0003212)2.51471427
67* B lymphocytopenia (HP:0010976)2.48858551
68Thrombophlebitis (HP:0004418)2.48179456
69* IgA deficiency (HP:0002720)2.47756201
70Mediastinal lymphadenopathy (HP:0100721)2.47636477
71Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.42218557
72Fibular aplasia (HP:0002990)2.41974819
73Abnormality of the pericardium (HP:0001697)2.41530574
74Keratitis (HP:0000491)2.40040796
75Spontaneous hematomas (HP:0007420)2.39763733
76Thrombocytosis (HP:0001894)2.36968804
77Abnormality of the endocardium (HP:0004306)2.36930010
78Oligodactyly (hands) (HP:0001180)2.34297624
79Inflammation of the large intestine (HP:0002037)2.29566045
80* Lymphoma (HP:0002665)2.28088018
81Basal cell carcinoma (HP:0002671)2.27215039
82Persistence of primary teeth (HP:0006335)2.27120577
83Hypoplasia of the thymus (HP:0000778)2.26457829
84Gastrointestinal inflammation (HP:0004386)2.25338151
85Recurrent skin infections (HP:0001581)2.21731945
86Enlarged epiphyses (HP:0010580)2.20258903
87Epistaxis (HP:0000421)2.16962876
88Radial bowing (HP:0002986)2.13989627
89Gingival bleeding (HP:0000225)2.11820180
90Albinism (HP:0001022)2.10722415
91Autoimmune thrombocytopenia (HP:0001973)2.10667352
92Cheilitis (HP:0100825)2.09056401
93Abnormality of the peritoneum (HP:0002585)2.04184950
94* Arthralgia (HP:0002829)2.03847944
95Amaurosis fugax (HP:0100576)1.98495498
96Thin bony cortex (HP:0002753)1.97646164
97Pulmonary fibrosis (HP:0002206)1.97568013
98Congenital stationary night blindness (HP:0007642)1.95472439
99Renal cortical cysts (HP:0000803)1.92080693
100Papilloma (HP:0012740)1.90856083
101Verrucae (HP:0200043)1.90856083
102Recurrent abscess formation (HP:0002722)1.90325451
103Aplasia/hypoplasia of the uterus (HP:0008684)1.89609907
104Interstitial pulmonary disease (HP:0006530)1.88997446
105Abnormality of male internal genitalia (HP:0000022)1.88145717
106Abnormality of the pons (HP:0007361)1.87946158
107Generalized hypopigmentation of hair (HP:0011358)1.86937644
108Abnormal platelet volume (HP:0011876)1.86921123
109Posterior subcapsular cataract (HP:0007787)1.85386994
110Ocular albinism (HP:0001107)1.84063062
111Recurrent bacterial skin infections (HP:0005406)1.83684272
112Synostosis involving the elbow (HP:0003938)1.83649523
113Humeroradial synostosis (HP:0003041)1.83649523
114* Bronchitis (HP:0012387)1.82690131
115Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.82569100
116Abnormality of alanine metabolism (HP:0010916)1.82569100
117Hyperalaninemia (HP:0003348)1.82569100
118Cerebral ischemia (HP:0002637)1.82378374
119Agammaglobulinemia (HP:0004432)1.81876068
120Neoplasm of the lung (HP:0100526)1.81493279
121Diplopia (HP:0000651)1.80616008
122Abnormality of binocular vision (HP:0011514)1.80616008
123Vertigo (HP:0002321)1.79599996
124Skin ulcer (HP:0200042)1.78757216
125Alveolar cell carcinoma (HP:0006519)1.78529725
126Petechiae (HP:0000967)1.78123085
127Abnormality of the costochondral junction (HP:0000919)1.77470412
128Hypoplasia of the pons (HP:0012110)1.76455531
129Abnormal spermatogenesis (HP:0008669)1.74519604
130Aplasia/Hypoplasia of the thymus (HP:0010515)1.74361221
131Reduced subcutaneous adipose tissue (HP:0003758)1.72729332
132Paresthesia (HP:0003401)1.69867778
133Chronic sinusitis (HP:0011109)1.68547214

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK8.06100091
2MAP4K15.30680854
3ITK3.38427443
4FGFR43.38356773
5ZAP703.38165661
6JAK33.33691593
7JAK12.53681445
8IKBKE2.42956123
9MAP3K92.38838677
10TYK22.36451546
11MAP3K142.23043953
12FGFR32.20671690
13STK102.07399633
14ARAF1.96418848
15TBK11.95207519
16TEC1.84367545
17LCK1.82673444
18BLK1.81967969
19KDR1.67906226
20NLK1.66716445
21GRK61.64721166
22EPHA31.62604964
23TESK21.52169385
24PASK1.49618867
25SYK1.48336757
26TAOK31.47437945
27MAP2K21.44209433
28HCK1.41133518
29RIPK41.40245411
30MAP4K21.35733851
31EPHB11.30437167
32CSK1.29300641
33BTK1.27948204
34CAMKK21.24026645
35PRKCQ1.21911296
36BMPR21.10517526
37IKBKB1.10443925
38KSR21.08925006
39IRAK31.06303406
40IRAK41.03269469
41JAK21.01553161
42CAMKK10.96146860
43EEF2K0.95744670
44CHUK0.93744675
45IRAK10.93673259
46TSSK60.93413317
47MAP3K120.89787191
48PRPF4B0.88816825
49ADRBK20.86925427
50PRKCH0.86554307
51PIM10.81867175
52MST40.81177341
53RAF10.80995904
54TLK10.80242835
55LRRK20.79898796
56TYRO30.79890162
57SIK30.79273885
58SIK20.79270761
59FES0.76629903
60KIT0.75753170
61CDK120.74896565
62MARK30.74797277
63MAP3K130.72633663
64MOS0.71277463
65TNK20.68075940
66NME20.67444989
67PRKCI0.65309343
68ZAK0.64479142
69PDGFRB0.64181878
70TGFBR20.64125214
71LYN0.63921903
72CSNK1G10.62261379
73RPS6KA40.60889459
74ALK0.60164623
75MAP3K70.60109757
76STK240.57985719
77CLK10.57348058
78FGFR10.56943708
79SGK20.56385244
80NEK60.56215214
81CDK60.55485464
82MAP3K100.54863138
83MAP3K10.54459250
84CDK40.54427377
85HIPK20.53532139
86TRIB30.53477059
87PIK3CA0.49563822
88PDK10.49238660
89WNK40.48373095
90MAPK70.46666728
91MAP2K60.46574433
92DMPK0.44563245
93MELK0.42443832
94TESK10.39910209
95BRD40.39601342
96MAPK120.39479014
97FYN0.39084117
98IGF1R0.38038410
99SGK2230.37956585
100SGK4940.37956585
101INSR0.37155129
102NUAK10.35679195
103KSR10.35370781
104RPS6KA50.33332565
105MAP2K10.32485441
106SGK30.31178766
107TAOK10.30230510
108CDK90.29500933
109CSF1R0.29301567
110MAPK110.27894888
111GRK10.27799352
112ILK0.27369128
113CSNK1A1L0.26935852
114SIK10.26540553
115FGFR20.26167043
116IRAK20.22980709
117NTRK20.22555821
118EIF2AK10.21843175
119MAPK30.20914347
120MAPKAPK20.20753931
121PKN20.19236972
122BRAF0.19178730
123GRK70.19053453
124NEK90.18619002
125NEK20.18464063
126SCYL20.18087354
127MARK20.17163585
128CDK80.17038469
129MAP3K110.16958249
130RET0.16223976
131PRKCD0.16061860
132PRKD20.14916114
133MAPK90.13567619
134TTN0.13081214
135MAP2K30.13025870
136EGFR0.12828428
137ABL10.12568558
138PTK60.11557020

Predicted pathways (KEGG)

RankGene SetZ-score
1Inflammatory bowel disease (IBD)_Homo sapiens_hsa053214.85613775
2* Primary immunodeficiency_Homo sapiens_hsa053404.83510101
3Allograft rejection_Homo sapiens_hsa053304.38266132
4* T cell receptor signaling pathway_Homo sapiens_hsa046604.00593019
5Autoimmune thyroid disease_Homo sapiens_hsa053203.77938447
6Asthma_Homo sapiens_hsa053103.24364472
7* Intestinal immune network for IgA production_Homo sapiens_hsa046723.15848485
8Measles_Homo sapiens_hsa051622.98335342
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.60501341
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.53801617
11Hematopoietic cell lineage_Homo sapiens_hsa046402.28674155
12Graft-versus-host disease_Homo sapiens_hsa053322.25961289
13Jak-STAT signaling pathway_Homo sapiens_hsa046302.25528072
14Antigen processing and presentation_Homo sapiens_hsa046122.08433170
15Leishmaniasis_Homo sapiens_hsa051401.95531122
16Osteoclast differentiation_Homo sapiens_hsa043801.93461930
17Viral myocarditis_Homo sapiens_hsa054161.83596905
18Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.76322108
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.47135261
20Toxoplasmosis_Homo sapiens_hsa051451.42008044
21Herpes simplex infection_Homo sapiens_hsa051681.36973346
22B cell receptor signaling pathway_Homo sapiens_hsa046621.35894062
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.34241753
24Chemokine signaling pathway_Homo sapiens_hsa040621.31144283
25TNF signaling pathway_Homo sapiens_hsa046681.23342552
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.21022017
27* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.20118238
28Hepatitis B_Homo sapiens_hsa051611.19063647
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.17952080
30Type I diabetes mellitus_Homo sapiens_hsa049401.17588005
31NOD-like receptor signaling pathway_Homo sapiens_hsa046211.11688891
32Shigellosis_Homo sapiens_hsa051311.08700914
33Influenza A_Homo sapiens_hsa051641.05744111
34Acute myeloid leukemia_Homo sapiens_hsa052211.05420045
35HTLV-I infection_Homo sapiens_hsa051661.04224582
36Leukocyte transendothelial migration_Homo sapiens_hsa046700.97759274
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.96724726
38Epstein-Barr virus infection_Homo sapiens_hsa051690.96705440
39Apoptosis_Homo sapiens_hsa042100.95503964
40Prolactin signaling pathway_Homo sapiens_hsa049170.94091650
41Pancreatic cancer_Homo sapiens_hsa052120.90489014
42Staphylococcus aureus infection_Homo sapiens_hsa051500.88273705
43Viral carcinogenesis_Homo sapiens_hsa052030.88009605
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.87021273
45Malaria_Homo sapiens_hsa051440.83979119
46Legionellosis_Homo sapiens_hsa051340.80891376
47Toll-like receptor signaling pathway_Homo sapiens_hsa046200.75445055
48Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.75261899
49Chronic myeloid leukemia_Homo sapiens_hsa052200.75010885
50Hepatitis C_Homo sapiens_hsa051600.73900999
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71848483
52Regulation of autophagy_Homo sapiens_hsa041400.71697209
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70828330
54VEGF signaling pathway_Homo sapiens_hsa043700.66832733
55Basal transcription factors_Homo sapiens_hsa030220.65923464
56Tuberculosis_Homo sapiens_hsa051520.65545878
57Linoleic acid metabolism_Homo sapiens_hsa005910.65248412
58Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63646350
59Platelet activation_Homo sapiens_hsa046110.63568828
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62214205
61Colorectal cancer_Homo sapiens_hsa052100.58155199
62Salmonella infection_Homo sapiens_hsa051320.57893993
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57743225
64alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54009993
65p53 signaling pathway_Homo sapiens_hsa041150.52910778
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.52642274
67Rheumatoid arthritis_Homo sapiens_hsa053230.52619050
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50287008
69Pertussis_Homo sapiens_hsa051330.49752185
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49388560
71Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47370153
72FoxO signaling pathway_Homo sapiens_hsa040680.44334069
73Endocytosis_Homo sapiens_hsa041440.44043418
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.42962470
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.42766274
76MAPK signaling pathway_Homo sapiens_hsa040100.41642864
77Spliceosome_Homo sapiens_hsa030400.40916430
78Small cell lung cancer_Homo sapiens_hsa052220.40546929
79Dorso-ventral axis formation_Homo sapiens_hsa043200.40147409
80Notch signaling pathway_Homo sapiens_hsa043300.39667289
81Renal cell carcinoma_Homo sapiens_hsa052110.39343438
82Ribosome_Homo sapiens_hsa030100.38802833
83Prion diseases_Homo sapiens_hsa050200.38123142
84RNA polymerase_Homo sapiens_hsa030200.38105639
85Arachidonic acid metabolism_Homo sapiens_hsa005900.37858110
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37784574
87Selenocompound metabolism_Homo sapiens_hsa004500.34032596
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33828113
89Nitrogen metabolism_Homo sapiens_hsa009100.32500998
90Non-small cell lung cancer_Homo sapiens_hsa052230.32081973
91Glycerolipid metabolism_Homo sapiens_hsa005610.31657035
92Circadian rhythm_Homo sapiens_hsa047100.31254494
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.31011292
94Inositol phosphate metabolism_Homo sapiens_hsa005620.29276008
95African trypanosomiasis_Homo sapiens_hsa051430.28519438
96RNA degradation_Homo sapiens_hsa030180.28021109
97Phototransduction_Homo sapiens_hsa047440.26350794
98Non-homologous end-joining_Homo sapiens_hsa034500.26217550
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.25373310
100Insulin resistance_Homo sapiens_hsa049310.25296045
101HIF-1 signaling pathway_Homo sapiens_hsa040660.23881261
102MicroRNAs in cancer_Homo sapiens_hsa052060.23230213
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23217487
104Rap1 signaling pathway_Homo sapiens_hsa040150.23140304
105Nucleotide excision repair_Homo sapiens_hsa034200.19647828
106Prostate cancer_Homo sapiens_hsa052150.18558596
107Ras signaling pathway_Homo sapiens_hsa040140.17983678
108Pathways in cancer_Homo sapiens_hsa052000.17344262
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.14515251
110Thyroid cancer_Homo sapiens_hsa052160.13456693
111Glycosaminoglycan degradation_Homo sapiens_hsa005310.12584506
112mRNA surveillance pathway_Homo sapiens_hsa030150.10209731
113mTOR signaling pathway_Homo sapiens_hsa041500.10146944
114Caffeine metabolism_Homo sapiens_hsa002320.09503379
115Proteoglycans in cancer_Homo sapiens_hsa052050.09080009
116Choline metabolism in cancer_Homo sapiens_hsa052310.08148140
117Adherens junction_Homo sapiens_hsa045200.07805980
118Proteasome_Homo sapiens_hsa030500.07617520
119Base excision repair_Homo sapiens_hsa034100.06228273
120Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.05858352
121Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.05438769
122Focal adhesion_Homo sapiens_hsa045100.04308845

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