ICOSLG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)6.03817773
2response to peptidoglycan (GO:0032494)4.32805902
3positive regulation of gamma-delta T cell activation (GO:0046645)4.26159207
4CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.24027537
5immunoglobulin mediated immune response (GO:0016064)4.03127144
6regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.02997382
7B cell receptor signaling pathway (GO:0050853)3.92936530
8negative regulation of interleukin-12 production (GO:0032695)3.90253278
9regulation of antigen processing and presentation (GO:0002577)3.86439036
10positive regulation of antigen processing and presentation (GO:0002579)3.85728969
11germinal center formation (GO:0002467)3.82878289
12regulation of interferon-beta biosynthetic process (GO:0045357)3.74746748
13cellular response to exogenous dsRNA (GO:0071360)3.67045002
14cellular response to ATP (GO:0071318)3.64977016
15macrophage activation involved in immune response (GO:0002281)3.62902056
16defense response to protozoan (GO:0042832)3.62541733
17response to muramyl dipeptide (GO:0032495)3.59645185
18regulation of B cell receptor signaling pathway (GO:0050855)3.58957563
19response to protozoan (GO:0001562)3.58669166
20NIK/NF-kappaB signaling (GO:0038061)3.58417515
21interferon-gamma-mediated signaling pathway (GO:0060333)3.56838418
22positive regulation by symbiont of host defense response (GO:0052509)3.53606634
23modulation by symbiont of host defense response (GO:0052031)3.53606634
24modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.53606634
25modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.53606634
26positive regulation by organism of defense response of other organism involved in symbiotic interact3.53606634
27modulation by symbiont of host immune response (GO:0052553)3.53606634
28regulation of interferon-alpha production (GO:0032647)3.51541478
29regulation of dendritic cell antigen processing and presentation (GO:0002604)3.49216487
30T-helper 1 type immune response (GO:0042088)3.46925093
31positive regulation of interferon-alpha production (GO:0032727)3.45365853
32purinergic nucleotide receptor signaling pathway (GO:0035590)3.43165343
33regulation of gamma-delta T cell activation (GO:0046643)3.40322911
34regulation of T-helper 1 cell differentiation (GO:0045625)3.33011019
35positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.28876028
36positive regulation of defense response to virus by host (GO:0002230)3.25005149
37mannose metabolic process (GO:0006013)3.24359681
38positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.22383822
39interferon-gamma production (GO:0032609)3.15179723
40positive thymic T cell selection (GO:0045059)3.14148168
41tolerance induction (GO:0002507)3.13070329
42positive regulation of mast cell activation (GO:0033005)3.12745490
43regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.11322484
44positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.05022323
45regulation of mast cell activation (GO:0033003)3.01188753
46regulation of interleukin-12 production (GO:0032655)3.00252907
47B cell homeostasis (GO:0001782)2.99939912
48antigen processing and presentation of endogenous antigen (GO:0019883)2.97908962
49purinergic receptor signaling pathway (GO:0035587)2.94272651
50B cell mediated immunity (GO:0019724)2.93058572
51negative regulation of cell killing (GO:0031342)2.92457482
52negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.92457482
53regulation of MHC class I biosynthetic process (GO:0045343)2.92301630
54positive regulation of protein homooligomerization (GO:0032464)2.90328124
55positive regulation of CREB transcription factor activity (GO:0032793)2.90292257
56response to type I interferon (GO:0034340)2.85560496
57N-acetylneuraminate metabolic process (GO:0006054)2.85500812
58myeloid dendritic cell differentiation (GO:0043011)2.85391663
59positive regulation of interleukin-12 production (GO:0032735)2.83282570
60lipopolysaccharide-mediated signaling pathway (GO:0031663)2.79197672
61negative regulation of interleukin-1 beta production (GO:0032691)2.78908507
62detection of bacterium (GO:0016045)2.78273152
63positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.77510609
64positive regulation of T-helper 1 type immune response (GO:0002827)2.77253476
65regulation of interferon-beta production (GO:0032648)2.76268501
66positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.76248270
67myeloid dendritic cell activation (GO:0001773)2.75611247
68positive regulation of mast cell activation involved in immune response (GO:0033008)2.75135192
69positive regulation of mast cell degranulation (GO:0043306)2.75135192
70positive regulation of heat generation (GO:0031652)2.73303393
71regulation of defense response to virus by host (GO:0050691)2.71803750
72regulation of T-helper cell differentiation (GO:0045622)2.71622992
73type I interferon signaling pathway (GO:0060337)2.71128763
74cellular response to type I interferon (GO:0071357)2.71128763
75myeloid cell activation involved in immune response (GO:0002275)2.70848538
76positive regulation of B cell proliferation (GO:0030890)2.70330240
77T cell lineage commitment (GO:0002360)2.70180155
78antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.69906955
79positive regulation of T-helper cell differentiation (GO:0045624)2.69768858
80positive regulation of interferon-beta production (GO:0032728)2.69102708
81cellular response to interferon-gamma (GO:0071346)2.68827261
82negative thymic T cell selection (GO:0045060)2.68248670
83regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.68045704
84regulation of interferon-gamma biosynthetic process (GO:0045072)2.68040621
85negative regulation of interleukin-6 production (GO:0032715)2.67601183
86regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.67228996
87regulation of vitamin D biosynthetic process (GO:0060556)2.66852822
88antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.66705300
89behavioral response to nicotine (GO:0035095)2.66554089
90detection of other organism (GO:0098543)2.64924694
91regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.63432967
92indole-containing compound catabolic process (GO:0042436)2.62826680
93indolalkylamine catabolic process (GO:0046218)2.62826680
94tryptophan catabolic process (GO:0006569)2.62826680
95response to exogenous dsRNA (GO:0043330)2.59065481
96thymic T cell selection (GO:0045061)2.58695600
97regulation of histone phosphorylation (GO:0033127)2.58400091
98regulation of germinal center formation (GO:0002634)2.57630699
99negative regulation of T cell mediated immunity (GO:0002710)2.56863758
100regulation of alpha-beta T cell proliferation (GO:0046640)2.56256884

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.31669649
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.56807639
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.47951059
4VDR_21846776_ChIP-Seq_THP-1_Human2.99902053
5* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.96141956
6MYC_22102868_ChIP-Seq_BL_Human2.91244374
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.72023681
8NOTCH1_21737748_ChIP-Seq_TLL_Human2.63882413
9VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.51016405
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.49074968
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.45943615
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.42188081
13VDR_24763502_ChIP-Seq_THP-1_Human2.38990721
14IKZF1_21737484_ChIP-ChIP_HCT116_Human2.36036413
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.28323026
16RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.12774602
17MAF_26560356_Chip-Seq_TH1_Human2.03334428
18SCL_19346495_ChIP-Seq_HPC-7_Human2.00618981
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.00155644
20RUNX_20019798_ChIP-Seq_JUKART_Human1.97878912
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.96644078
22BP1_19119308_ChIP-ChIP_Hs578T_Human1.88342654
23* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.87450604
24STAT6_21828071_ChIP-Seq_BEAS2B_Human1.85411360
25ZNF274_21170338_ChIP-Seq_K562_Hela1.84990628
26BCL6_27268052_Chip-Seq_Bcells_Human1.82067668
27MAF_26560356_Chip-Seq_TH2_Human1.79073775
28* MYB_26560356_Chip-Seq_TH2_Human1.69202862
29BCOR_27268052_Chip-Seq_Bcells_Human1.66599665
30LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.66329668
31STAT4_19710469_ChIP-ChIP_TH1__Mouse1.65840343
32PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.64510815
33MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.56302819
34SPI1_23547873_ChIP-Seq_NB4_Human1.56196282
35EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.55836779
36VDR_24787735_ChIP-Seq_THP-1_Human1.55770039
37LXR_22292898_ChIP-Seq_THP-1_Human1.54831588
38NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.51094926
39UTX_26944678_Chip-Seq_JUKART_Human1.49778774
40CIITA_25753668_ChIP-Seq_RAJI_Human1.43724284
41GATA1_22025678_ChIP-Seq_K562_Human1.43401652
42P68_20966046_ChIP-Seq_HELA_Human1.42464351
43RUNX1_22412390_ChIP-Seq_EML_Mouse1.42297332
44GATA3_26560356_Chip-Seq_TH2_Human1.41293894
45GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.40065608
46* MYB_26560356_Chip-Seq_TH1_Human1.39847322
47GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.35268771
48TCF7_22412390_ChIP-Seq_EML_Mouse1.34179686
49CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.34081916
50* E2F1_20622854_ChIP-Seq_HELA_Human1.34058666
51DROSHA_22980978_ChIP-Seq_HELA_Human1.33343481
52SPI1_23127762_ChIP-Seq_K562_Human1.31367543
53STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.28601031
54RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.28443368
55GATA3_27048872_Chip-Seq_THYMUS_Human1.28073720
56KDM2B_26808549_Chip-Seq_DND41_Human1.27591951
57LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.27163833
58PU.1_20513432_ChIP-Seq_Bcells_Mouse1.26591524
59P300_27268052_Chip-Seq_Bcells_Human1.25473010
60* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.24670194
61ELF1_20517297_ChIP-Seq_JURKAT_Human1.24390360
62FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.24173577
63CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21870663
64FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.21751950
65PHF8_20622854_ChIP-Seq_HELA_Human1.21424836
66VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.19483949
67RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.18946200
68SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18111526
69NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.17180494
70KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.17042959
71ERA_21632823_ChIP-Seq_H3396_Human1.16304050
72* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.16076326
73PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14835409
74MYB_21317192_ChIP-Seq_ERMYB_Mouse1.13256602
75CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12479772
76NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.12252809
77CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10882551
78BRD4_27068464_Chip-Seq_AML-cells_Mouse1.10613960
79GATA1_19941827_ChIP-Seq_MEL_Mouse1.09590212
80CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08171256
81ESR1_21235772_ChIP-Seq_MCF-7_Human1.08084104
82STAT1_20625510_ChIP-Seq_HELA_Human1.07125976
83TAF2_19829295_ChIP-Seq_ESCs_Human1.06783753
84STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.05763755
85SA1_27219007_Chip-Seq_Bcells_Human1.05646691
86FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04033842
87SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03695495
88P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.03630065
89PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02804331
90SMRT_27268052_Chip-Seq_Bcells_Human1.02042208
91SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.01193593
92YY1_22570637_ChIP-Seq_MALME-3M_Human1.00777738
93GATA3_21878914_ChIP-Seq_MCF-7_Human1.00454091
94SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00095850
95RARB_24833708_ChIP-Seq_LIVER_Mouse0.99006465
96TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97602966
97OCT4_19829295_ChIP-Seq_ESCs_Human0.97419028
98* RAC3_21632823_ChIP-Seq_H3396_Human0.97347286
99PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96732774
100ESR2_21235772_ChIP-Seq_MCF-7_Human0.96072369

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000685_abnormal_immune_system3.63703024
2MP0005671_abnormal_response_to3.52630010
3MP0005387_immune_system_phenotype3.47055106
4MP0001790_abnormal_immune_system3.47055106
5MP0001835_abnormal_antigen_presentation3.45632703
6MP0002138_abnormal_hepatobiliary_system3.22346182
7MP0001800_abnormal_humoral_immune3.17485796
8MP0003303_peritoneal_inflammation3.09281963
9MP0003436_decreased_susceptibility_to3.02234512
10MP0002148_abnormal_hypersensitivity_rea2.92082384
11MP0005000_abnormal_immune_tolerance2.81174558
12MP0002452_abnormal_antigen_presenting2.63858024
13MP0002723_abnormal_immune_serum2.61396796
14MP0009785_altered_susceptibility_to2.35201998
15MP0002419_abnormal_innate_immunity2.34234651
16MP0005025_abnormal_response_to2.31444778
17MP0002420_abnormal_adaptive_immunity2.30153164
18MP0001819_abnormal_immune_cell2.27567179
19MP0001986_abnormal_taste_sensitivity2.25282156
20MP0003724_increased_susceptibility_to2.23682519
21MP0001873_stomach_inflammation2.18434105
22MP0005167_abnormal_blood-brain_barrier2.12495159
23MP0005310_abnormal_salivary_gland2.01707832
24MP0002254_reproductive_system_inflammat1.98539483
25MP0009840_abnormal_foam_cell1.91480819
26MP0003172_abnormal_lysosome_physiology1.84712886
27MP0000716_abnormal_immune_system1.81199802
28MP0006082_CNS_inflammation1.78284340
29MP0009764_decreased_sensitivity_to1.77824553
30MP0009333_abnormal_splenocyte_physiolog1.67591190
31MP0002405_respiratory_system_inflammati1.65459939
32MP0005058_abnormal_lysosome_morphology1.64700604
33MP0003763_abnormal_thymus_physiology1.64149083
34MP0002398_abnormal_bone_marrow1.62914649
35MP0001845_abnormal_inflammatory_respons1.62232598
36MP0003195_calcinosis1.61414864
37MP0010155_abnormal_intestine_physiology1.57876173
38MP0009278_abnormal_bone_marrow1.57516554
39MP0001533_abnormal_skeleton_physiology1.49486476
40MP0004510_myositis1.48836709
41MP0004947_skin_inflammation1.48341187
42MP0000689_abnormal_spleen_morphology1.44874364
43MP0004381_abnormal_hair_follicle1.38515825
44MP0002429_abnormal_blood_cell1.38124567
45MP0002139_abnormal_hepatobiliary_system1.35787764
46MP0003300_gastrointestinal_ulcer1.35011196
47MP0008469_abnormal_protein_level1.34862572
48MP0005174_abnormal_tail_pigmentation1.26136775
49MP0002722_abnormal_immune_system1.16366399
50MP0004043_abnormal_pH_regulation1.15169324
51MP0002933_joint_inflammation1.08811203
52MP0001663_abnormal_digestive_system1.08103813
53MP0003806_abnormal_nucleotide_metabolis1.07099624
54MP0001968_abnormal_touch/_nociception1.04775599
55MP0008872_abnormal_physiological_respon1.00968743
56MP0002277_abnormal_respiratory_mucosa0.96506322
57MP0003646_muscle_fatigue0.96163974
58MP0002998_abnormal_bone_remodeling0.95745026
59MP0001853_heart_inflammation0.95269331
60MP0003075_altered_response_to0.93130083
61MP0000604_amyloidosis0.93085907
62MP0005423_abnormal_somatic_nervous0.91541381
63MP0003183_abnormal_peptide_metabolism0.90434799
64MP0002653_abnormal_ependyma_morphology0.90420905
65MP0003136_yellow_coat_color0.89690605
66MP0004742_abnormal_vestibular_system0.89434561
67MP0001501_abnormal_sleep_pattern0.88441732
68MP0002693_abnormal_pancreas_physiology0.88273762
69MP0003045_fibrosis0.84589394
70MP0003690_abnormal_glial_cell0.83329986
71MP0000015_abnormal_ear_pigmentation0.80018700
72MP0000703_abnormal_thymus_morphology0.79721090
73MP0001545_abnormal_hematopoietic_system0.79487151
74MP0005397_hematopoietic_system_phenotyp0.79487151
75MP0008875_abnormal_xenobiotic_pharmacok0.78563288
76MP0000383_abnormal_hair_follicle0.75830267
77MP0005464_abnormal_platelet_physiology0.74326851
78MP0002064_seizures0.72530898
79MP0005166_decreased_susceptibility_to0.71769061
80MP0000371_diluted_coat_color0.71150153
81MP0009745_abnormal_behavioral_response0.70241901
82MP0008874_decreased_physiological_sensi0.70070888
83MP0003866_abnormal_defecation0.69956101
84MP0002136_abnormal_kidney_physiology0.68429148
85MP0002166_altered_tumor_susceptibility0.67103272
86MP0000249_abnormal_blood_vessel0.66230759
87MP0009046_muscle_twitch0.65812106
88MP0002006_tumorigenesis0.65274013
89MP0005645_abnormal_hypothalamus_physiol0.64759238
90MP0005076_abnormal_cell_differentiation0.60921291
91MP0005381_digestive/alimentary_phenotyp0.60092910
92MP0000470_abnormal_stomach_morphology0.60063936
93MP0000343_altered_response_to0.59289366
94MP0005448_abnormal_energy_balance0.58761401
95MP0000920_abnormal_myelination0.58452336
96MP0005075_abnormal_melanosome_morpholog0.57478797
97MP0001765_abnormal_ion_homeostasis0.55944034
98MP0005551_abnormal_eye_electrophysiolog0.55325059
99MP0003453_abnormal_keratinocyte_physiol0.54908702
100MP0008961_abnormal_basal_metabolism0.54595975

Predicted human phenotypes

RankGene SetZ-score
1Increased neuronal autofluorescent lipopigment (HP:0002074)4.51738401
2Increased cerebral lipofuscin (HP:0011813)4.44302302
3Panhypogammaglobulinemia (HP:0003139)4.31254550
4Gastrointestinal stroma tumor (HP:0100723)4.16995614
5Agammaglobulinemia (HP:0004432)4.09583763
6Chronic mucocutaneous candidiasis (HP:0002728)4.05960260
7Recurrent cutaneous fungal infections (HP:0011370)4.05960260
8Abnormal delayed hypersensitivity skin test (HP:0002963)3.88141312
9Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.87441763
10Recurrent fungal infections (HP:0002841)3.69994199
11Congenital stationary night blindness (HP:0007642)3.52569842
12Vacuolated lymphocytes (HP:0001922)3.40585606
13Abnormality of glycolipid metabolism (HP:0010969)3.28542575
14Abnormality of liposaccharide metabolism (HP:0010968)3.28542575
15Abnormality of glycosphingolipid metabolism (HP:0004343)3.28542575
16Meningitis (HP:0001287)3.26939870
17Mediastinal lymphadenopathy (HP:0100721)3.26810962
18Stomatitis (HP:0010280)3.26471268
19Recurrent viral infections (HP:0004429)3.19649683
20Colitis (HP:0002583)3.12711918
21Encephalitis (HP:0002383)3.08221431
22Retrobulbar optic neuritis (HP:0100654)2.92759903
23Optic neuritis (HP:0100653)2.92759903
24Vasculitis (HP:0002633)2.89602195
25Recurrent bacterial skin infections (HP:0005406)2.87814798
26Abnormality of macrophages (HP:0004311)2.86953682
27Recurrent skin infections (HP:0001581)2.80335102
28Pustule (HP:0200039)2.80041686
29Attenuation of retinal blood vessels (HP:0007843)2.78023730
30Recurrent abscess formation (HP:0002722)2.72266584
31Recurrent sinusitis (HP:0011108)2.71524697
32Elevated erythrocyte sedimentation rate (HP:0003565)2.70672069
33Myositis (HP:0100614)2.66186015
34Global brain atrophy (HP:0002283)2.65330223
35Autoimmune thrombocytopenia (HP:0001973)2.64031867
36Orchitis (HP:0100796)2.63972529
37Mesangial abnormality (HP:0001966)2.62645176
38Clumsiness (HP:0002312)2.57509705
39Abnormality of T cell physiology (HP:0011840)2.55138101
40Abnormality of B cell number (HP:0010975)2.55104486
41IgG deficiency (HP:0004315)2.51948784
42Pulmonary infiltrates (HP:0002113)2.45825334
43Inflammation of the large intestine (HP:0002037)2.32055248
44B lymphocytopenia (HP:0010976)2.30054883
45Genetic anticipation (HP:0003743)2.28253706
46Dysostosis multiplex (HP:0000943)2.25048340
47Hemoptysis (HP:0002105)2.24315040
48Eczematoid dermatitis (HP:0000976)2.23229125
49Restrictive lung disease (HP:0002091)2.22442127
50Verrucae (HP:0200043)2.18617875
51Papilloma (HP:0012740)2.18617875
52Decreased circulating renin level (HP:0003351)2.18135938
53Recurrent bronchitis (HP:0002837)2.16756876
54Abnormality of T cells (HP:0002843)2.15960794
55Gastrointestinal inflammation (HP:0004386)2.15276092
56Lymphopenia (HP:0001888)2.14914039
57Mutism (HP:0002300)2.13402000
58Chronic otitis media (HP:0000389)2.12428502
59Stomach cancer (HP:0012126)2.05337221
60Increased serum ferritin (HP:0003281)2.04308211
61Pendular nystagmus (HP:0012043)2.01564502
62Bone cyst (HP:0012062)2.00004788
63Gastrointestinal infarctions (HP:0005244)1.98418221
64Polydipsia (HP:0001959)1.96087864
65Abnormal drinking behavior (HP:0030082)1.96087864
66Flat occiput (HP:0005469)1.95209793
67Emphysema (HP:0002097)1.95004438
68Increased IgE level (HP:0003212)1.94181662
69Abnormality of polysaccharide metabolism (HP:0011012)1.94021024
70Abnormality of glycosaminoglycan metabolism (HP:0004371)1.94021024
71Abnormality of mucopolysaccharide metabolism (HP:0011020)1.94021024
72Keratoconjunctivitis (HP:0001096)1.93267410
73Abnormality of cells of the lymphoid lineage (HP:0012140)1.92967165
74Birth length less than 3rd percentile (HP:0003561)1.92380657
75Progressive inability to walk (HP:0002505)1.91048992
76Hematochezia (HP:0002573)1.89570313
77IgA deficiency (HP:0002720)1.86646609
78Viral hepatitis (HP:0006562)1.86307679
79Tinnitus (HP:0000360)1.86250276
80Recurrent lower respiratory tract infections (HP:0002783)1.84802695
81Loss of speech (HP:0002371)1.82620495
82Large for gestational age (HP:0001520)1.82408637
83Decreased electroretinogram (ERG) amplitude (HP:0000654)1.80220850
84Progressive cerebellar ataxia (HP:0002073)1.79960048
85Diplopia (HP:0000651)1.79170729
86Abnormality of binocular vision (HP:0011514)1.79170729
87Protruding tongue (HP:0010808)1.77749635
88Recurrent pneumonia (HP:0006532)1.77408989
89Keratoconjunctivitis sicca (HP:0001097)1.76364906
90Leukopenia (HP:0001882)1.73517475
91Parakeratosis (HP:0001036)1.73397996
92Abnormality of the pleura (HP:0002103)1.73067383
93Urticaria (HP:0001025)1.73012579
94Amelogenesis imperfecta (HP:0000705)1.72455898
95Abnormality of transition element cation homeostasis (HP:0011030)1.71862117
96Abnormality of the prostate (HP:0008775)1.71491105
97Polyneuropathy (HP:0001271)1.70512529
98Inability to walk (HP:0002540)1.67815641
99Cheilitis (HP:0100825)1.67426528
100Abolished electroretinogram (ERG) (HP:0000550)1.66628217

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.97502203
2ACVR1B3.55355574
3BMPR1B3.46517405
4RIPK43.40181610
5BLK2.77908927
6ADRBK22.54952646
7TGFBR12.43899506
8MAP3K142.42366108
9SIK22.36930506
10IKBKB2.35897368
11IRAK42.09672728
12KIT2.07565547
13IRAK32.06091304
14FRK1.99017752
15TXK1.91609307
16IKBKE1.91281898
17TBK11.88848005
18SYK1.75468559
19DAPK21.70765926
20CSF1R1.70635320
21CHUK1.64839084
22TAOK31.64220313
23PRPF4B1.58502469
24MATK1.57545880
25TYK21.52871287
26MAPK151.46797002
27SIK31.42542301
28CDC42BPA1.40337944
29CAMK1D1.34156788
30ERN11.32195555
31GRK61.30112290
32MAP3K131.28916120
33LYN1.21008361
34MAPKAPK31.20408397
35CSK1.16923798
36BTK1.12318498
37NME21.11935798
38WNK41.11449472
39IRAK11.10108072
40TNK21.09074865
41TLK11.08745816
42GRK11.08124451
43FGR1.07598156
44MAP3K111.06413631
45JAK31.04240334
46ZAP700.95043294
47SMG10.94950203
48CAMKK20.92983751
49MAPK120.92886967
50CAMKK10.91672606
51RPS6KA60.88577113
52MAP2K60.88563119
53TRIB30.88358178
54BMPR20.88047881
55EEF2K0.86815984
56MAP2K20.83654625
57FES0.81677787
58LCK0.80884487
59PRKCQ0.79536834
60ITK0.73563261
61JAK10.73264877
62TRPM70.72027497
63MAPK70.71272048
64IRAK20.68470892
65HIPK20.67141821
66HCK0.66136151
67MARK30.64984261
68SIK10.64412926
69PDK10.63692933
70PRKD20.62741356
71MAPK110.61540077
72MAP3K10.59166409
73PIM10.56216747
74PRKCH0.55614627
75ZAK0.54992338
76MAP2K30.54839468
77MELK0.54041687
78PDPK10.54002278
79GRK70.52671583
80TAOK10.52159092
81BCKDK0.51905069
82CDK40.49810299
83ADRBK10.49797663
84TEC0.46475474
85MAPK40.42981867
86JAK20.40492069
87CDK80.38852441
88MAP2K10.38566199
89TYRO30.38421904
90MAPKAPK50.36365515
91RPS6KC10.36092315
92RPS6KL10.36092315
93STK110.35935372
94CAMK1G0.35650564
95MAPK130.35229941
96WNK10.35211581
97MARK20.34309021
98DDR20.32545370
99ABL10.31847139
100MAPK30.31391334

Predicted pathways (KEGG)

RankGene SetZ-score
1* Intestinal immune network for IgA production_Homo sapiens_hsa046723.87999459
2Asthma_Homo sapiens_hsa053103.82283389
3Allograft rejection_Homo sapiens_hsa053303.61467502
4Graft-versus-host disease_Homo sapiens_hsa053323.25772309
5Autoimmune thyroid disease_Homo sapiens_hsa053203.22573587
6Type I diabetes mellitus_Homo sapiens_hsa049402.86884582
7Primary immunodeficiency_Homo sapiens_hsa053402.84030680
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.76858939
9Staphylococcus aureus infection_Homo sapiens_hsa051502.63318395
10Leishmaniasis_Homo sapiens_hsa051402.37116093
11B cell receptor signaling pathway_Homo sapiens_hsa046622.33016798
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.23068478
13NF-kappa B signaling pathway_Homo sapiens_hsa040642.12885503
14Antigen processing and presentation_Homo sapiens_hsa046122.07016888
15Rheumatoid arthritis_Homo sapiens_hsa053231.98807867
16Other glycan degradation_Homo sapiens_hsa005111.90083006
17Tuberculosis_Homo sapiens_hsa051521.86504995
18Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.84511460
19Osteoclast differentiation_Homo sapiens_hsa043801.78430946
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.73263438
21Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.66961795
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.64943053
23Toxoplasmosis_Homo sapiens_hsa051451.52113123
24Hematopoietic cell lineage_Homo sapiens_hsa046401.47609421
25TNF signaling pathway_Homo sapiens_hsa046681.47455753
26Influenza A_Homo sapiens_hsa051641.46164257
27Lysosome_Homo sapiens_hsa041421.42216070
28Viral myocarditis_Homo sapiens_hsa054161.36232648
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.26522323
30Herpes simplex infection_Homo sapiens_hsa051681.24998306
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.23605558
32Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.20425328
33T cell receptor signaling pathway_Homo sapiens_hsa046601.08041194
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.02953941
35Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.96052105
36Ether lipid metabolism_Homo sapiens_hsa005650.91348993
37Measles_Homo sapiens_hsa051620.90270371
38Chemokine signaling pathway_Homo sapiens_hsa040620.89708791
39Linoleic acid metabolism_Homo sapiens_hsa005910.88214657
40Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.85927169
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.85624036
42Glycosaminoglycan degradation_Homo sapiens_hsa005310.84939488
43Pertussis_Homo sapiens_hsa051330.84848841
44Dorso-ventral axis formation_Homo sapiens_hsa043200.84605131
45Jak-STAT signaling pathway_Homo sapiens_hsa046300.82763218
46Epstein-Barr virus infection_Homo sapiens_hsa051690.82148232
47Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.81426626
48* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80593666
49Legionellosis_Homo sapiens_hsa051340.80410826
50Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.77916372
51African trypanosomiasis_Homo sapiens_hsa051430.71340251
52Hepatitis C_Homo sapiens_hsa051600.71103898
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71021430
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70460020
55Hepatitis B_Homo sapiens_hsa051610.69342039
56Acute myeloid leukemia_Homo sapiens_hsa052210.68424772
57Phagosome_Homo sapiens_hsa041450.63672613
58Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63304327
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61012716
60Bladder cancer_Homo sapiens_hsa052190.59796431
61Nitrogen metabolism_Homo sapiens_hsa009100.59430426
62Apoptosis_Homo sapiens_hsa042100.53877254
63Tryptophan metabolism_Homo sapiens_hsa003800.53127555
64ABC transporters_Homo sapiens_hsa020100.52689513
65Malaria_Homo sapiens_hsa051440.52512210
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.51199516
67Sphingolipid metabolism_Homo sapiens_hsa006000.50805882
68Collecting duct acid secretion_Homo sapiens_hsa049660.50471727
69MAPK signaling pathway_Homo sapiens_hsa040100.49332068
70Cyanoamino acid metabolism_Homo sapiens_hsa004600.48841860
71VEGF signaling pathway_Homo sapiens_hsa043700.47291569
72Sulfur relay system_Homo sapiens_hsa041220.47092174
73Phototransduction_Homo sapiens_hsa047440.44776648
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41899236
75Morphine addiction_Homo sapiens_hsa050320.40997566
76Type II diabetes mellitus_Homo sapiens_hsa049300.40958120
77Prolactin signaling pathway_Homo sapiens_hsa049170.40638809
78Selenocompound metabolism_Homo sapiens_hsa004500.40341374
79HTLV-I infection_Homo sapiens_hsa051660.38945133
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.35546779
81Ovarian steroidogenesis_Homo sapiens_hsa049130.34113921
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.33259185
83Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.33149816
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.33021432
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31247484
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.30858254
87GnRH signaling pathway_Homo sapiens_hsa049120.29213273
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.28386627
89Insulin resistance_Homo sapiens_hsa049310.26570285
90Arachidonic acid metabolism_Homo sapiens_hsa005900.25925500
91Platelet activation_Homo sapiens_hsa046110.24430420
92Mineral absorption_Homo sapiens_hsa049780.24285772
93Calcium signaling pathway_Homo sapiens_hsa040200.22395829
94Glycerolipid metabolism_Homo sapiens_hsa005610.20439079
95Vitamin digestion and absorption_Homo sapiens_hsa049770.19204684
96Salmonella infection_Homo sapiens_hsa051320.15173749
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.13233914
98Estrogen signaling pathway_Homo sapiens_hsa049150.12951572
99Oxytocin signaling pathway_Homo sapiens_hsa049210.12927457
100Long-term depression_Homo sapiens_hsa047300.12321791

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