ID1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1atrioventricular valve morphogenesis (GO:0003181)3.93541808
2lymph vessel development (GO:0001945)3.93419928
3outer ear morphogenesis (GO:0042473)3.90390379
4chondrocyte proliferation (GO:0035988)3.90180939
5basement membrane organization (GO:0071711)3.79123184
6notochord development (GO:0030903)3.75169550
7endocardial cushion morphogenesis (GO:0003203)3.75166685
8mesenchyme morphogenesis (GO:0072132)3.73606411
9protein retention in ER lumen (GO:0006621)3.67993298
10paraxial mesoderm development (GO:0048339)3.66867844
11maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.65910641
12hemidesmosome assembly (GO:0031581)3.64572751
13Golgi transport vesicle coating (GO:0048200)3.58480460
14COPI coating of Golgi vesicle (GO:0048205)3.58480460
15viral transcription (GO:0019083)3.54493281
16desmosome organization (GO:0002934)3.53537273
17cell surface receptor signaling pathway involved in heart development (GO:0061311)3.51650266
18translational termination (GO:0006415)3.41877081
19Notch signaling involved in heart development (GO:0061314)3.41612304
20polarized epithelial cell differentiation (GO:0030859)3.39884651
21epithelial cell-cell adhesion (GO:0090136)3.34693980
22regulation of heart morphogenesis (GO:2000826)3.27680574
23bundle of His cell to Purkinje myocyte communication (GO:0086069)3.27571840
24negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.24622376
25endothelium development (GO:0003158)3.21463162
26morphogenesis of an endothelium (GO:0003159)3.20889364
27endothelial tube morphogenesis (GO:0061154)3.20889364
28cell proliferation involved in kidney development (GO:0072111)3.18705035
29establishment of apical/basal cell polarity (GO:0035089)3.18137075
30regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.17008710
31regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.12982768
32positive regulation of epithelial to mesenchymal transition (GO:0010718)3.10000162
33regulation of tight junction assembly (GO:2000810)3.09684461
34regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.07586993
35vascular endothelial growth factor signaling pathway (GO:0038084)3.05451453
36ribosomal small subunit assembly (GO:0000028)3.03177795
37mesenchymal cell proliferation (GO:0010463)3.02288163
38heart valve morphogenesis (GO:0003179)3.02205466
39cell migration involved in heart development (GO:0060973)3.02078413
40renal filtration (GO:0097205)3.01146657
41adherens junction assembly (GO:0034333)2.99357266
42middle ear morphogenesis (GO:0042474)2.98156357
43translational elongation (GO:0006414)2.97905303
44regulation of endothelial cell differentiation (GO:0045601)2.97267857
45regulation of posttranscriptional gene silencing (GO:0060147)2.95949234
46regulation of gene silencing by miRNA (GO:0060964)2.95949234
47regulation of gene silencing by RNA (GO:0060966)2.95949234
48negative regulation of cell fate specification (GO:0009996)2.93719212
49cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.91293937
50ribosomal small subunit biogenesis (GO:0042274)2.89741094
51cell-substrate junction assembly (GO:0007044)2.88552020
52negative regulation of chondrocyte differentiation (GO:0032331)2.88322132
53regulation of hippo signaling (GO:0035330)2.87822826
54gap junction assembly (GO:0016264)2.87156557
55epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.86830349
56proline biosynthetic process (GO:0006561)2.86622429
57focal adhesion assembly (GO:0048041)2.85498205
58cell-substrate adherens junction assembly (GO:0007045)2.85498205
59positive regulation of cartilage development (GO:0061036)2.85315611
60branching involved in mammary gland duct morphogenesis (GO:0060444)2.85083229
61G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.85075430
62regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.83697071
63protein hydroxylation (GO:0018126)2.82507110
64regulation of SMAD protein import into nucleus (GO:0060390)2.82079269
65negative regulation of myoblast differentiation (GO:0045662)2.81954419
66cell migration involved in sprouting angiogenesis (GO:0002042)2.80915161
67lymphangiogenesis (GO:0001946)2.80043433
68viral life cycle (GO:0019058)2.80025334
69cardiac epithelial to mesenchymal transition (GO:0060317)2.79717251
70retina vasculature morphogenesis in camera-type eye (GO:0061299)2.77679123
71regulation of cardioblast proliferation (GO:0003264)2.77158498
72regulation of secondary heart field cardioblast proliferation (GO:0003266)2.77158498
73NADH metabolic process (GO:0006734)2.76307358
74mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.74849234
75SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.74567865
76midgut development (GO:0007494)2.74301921
77positive regulation of osteoblast proliferation (GO:0033690)2.74120577
78embryonic skeletal joint morphogenesis (GO:0060272)2.73585261
79planar cell polarity pathway involved in neural tube closure (GO:0090179)2.73370830
80protein maturation by protein folding (GO:0022417)2.71896459
81protein targeting to ER (GO:0045047)2.71561024
82glomerular filtration (GO:0003094)2.70558307
83mesodermal cell differentiation (GO:0048333)2.68875151
84hippo signaling (GO:0035329)2.68662633
85respiratory tube development (GO:0030323)2.68214582
86regulation of apoptotic process involved in morphogenesis (GO:1902337)2.67172362
87embryonic process involved in female pregnancy (GO:0060136)2.66780843
88neural crest cell development (GO:0014032)2.66401999
89convergent extension (GO:0060026)2.66037572
90regulation of cell fate specification (GO:0042659)2.65964666
91wound healing, spreading of epidermal cells (GO:0035313)2.65591883
92cell proliferation involved in metanephros development (GO:0072203)2.65239245
93* endothelial cell morphogenesis (GO:0001886)2.63701525
94regulation of cardioblast differentiation (GO:0051890)2.63347098
95cotranslational protein targeting to membrane (GO:0006613)2.62646812
96positive regulation of endothelial cell differentiation (GO:0045603)2.62279899
97GDP-mannose metabolic process (GO:0019673)2.61383912
98cellular protein complex localization (GO:0034629)2.61059735
99ventricular cardiac muscle cell development (GO:0055015)2.60563781
100cellular protein complex disassembly (GO:0043624)2.58196386
1014-hydroxyproline metabolic process (GO:0019471)2.58100154
102renal system development (GO:0072001)2.57587536
103positive regulation of SMAD protein import into nucleus (GO:0060391)2.57215967
104regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.57178319
105negative regulation of catenin import into nucleus (GO:0035414)2.57003929
106urea cycle (GO:0000050)2.56811973
107aorta morphogenesis (GO:0035909)2.56696158
108endocardial cushion development (GO:0003197)2.56652500
109nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.56552005
110endodermal cell differentiation (GO:0035987)2.54634883
111establishment of protein localization to endoplasmic reticulum (GO:0072599)2.54459372
112metanephric mesenchyme development (GO:0072075)2.54274693
113branching involved in salivary gland morphogenesis (GO:0060445)2.52846615
114neuron projection extension involved in neuron projection guidance (GO:1902284)2.52027081
115axon extension involved in axon guidance (GO:0048846)2.52027081
116regulation of translational fidelity (GO:0006450)2.51492515
117protein heterotrimerization (GO:0070208)2.50029971
118* blood vessel endothelial cell migration (GO:0043534)2.49324548
119wound healing, spreading of cells (GO:0044319)2.49284794
120kidney mesenchyme development (GO:0072074)2.49217238
121positive regulation of endothelial cell apoptotic process (GO:2000353)2.48544706
122organ formation (GO:0048645)2.48502386
123negative regulation of keratinocyte proliferation (GO:0010839)2.48347083
124nucleobase-containing small molecule interconversion (GO:0015949)2.48215743
125regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.48136400
126activation of Rac GTPase activity (GO:0032863)2.47373583
127Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.46999648
128translational initiation (GO:0006413)2.46961836
129establishment or maintenance of monopolar cell polarity (GO:0061339)2.46026115
130establishment of monopolar cell polarity (GO:0061162)2.46026115
131protein localization to endoplasmic reticulum (GO:0070972)2.45194800
132regulation of gastrulation (GO:0010470)2.45122323
133vasculogenesis (GO:0001570)2.44916675
134lung epithelium development (GO:0060428)2.44484958
135organ induction (GO:0001759)2.43884879
136regulation of cholesterol homeostasis (GO:2000188)2.43555641
137response to laminar fluid shear stress (GO:0034616)2.39403345
138protein complex localization (GO:0031503)2.38999817
139nucleotide-sugar biosynthetic process (GO:0009226)2.37486134
140morphogenesis of embryonic epithelium (GO:0016331)2.34315012
141retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.33227255
142regulation of glucocorticoid metabolic process (GO:0031943)2.32257581
143muscle cell migration (GO:0014812)2.30506685
144urea metabolic process (GO:0019627)2.30439917
145regulation of establishment of planar polarity (GO:0090175)2.30132296
146proline metabolic process (GO:0006560)2.27635699
147negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.26977440
148regulation of mitotic spindle organization (GO:0060236)2.26486123
149non-canonical Wnt signaling pathway (GO:0035567)2.26230501
150barbed-end actin filament capping (GO:0051016)2.26169961
151establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.25409725
152mitotic chromosome condensation (GO:0007076)2.25398325
153positive regulation of pseudopodium assembly (GO:0031274)2.24944548
154mitotic nuclear envelope reassembly (GO:0007084)2.24635683
155nuclear envelope reassembly (GO:0031468)2.24635683
156protein localization to cell surface (GO:0034394)2.24384535
157peptidyl-proline hydroxylation (GO:0019511)2.24374326
158skin morphogenesis (GO:0043589)2.21117015
159actin filament depolymerization (GO:0030042)2.19865760
160regulation of metalloenzyme activity (GO:0048552)2.19272893
161glutamine family amino acid biosynthetic process (GO:0009084)2.18711196
162apoptotic process involved in morphogenesis (GO:0060561)2.17889477
163regulation of catenin import into nucleus (GO:0035412)2.17430607
164glucose catabolic process (GO:0006007)2.12901797
165endothelial cell chemotaxis (GO:0035767)2.11926916
166regulation of mammary gland epithelial cell proliferation (GO:0033599)2.11896859
167negative regulation of cartilage development (GO:0061037)2.11599702

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.50215801
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.62448760
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.32272428
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.54967380
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.50378072
6* CLOCK_20551151_ChIP-Seq_293T_Human2.74422276
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.72529768
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.72529768
9KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.72529768
10* NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.53456681
11* SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.48380332
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.43871397
13HIF1A_21447827_ChIP-Seq_MCF-7_Human2.43713335
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.22117871
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.21458388
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.05567557
17POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.02234957
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.00287181
19* ELK3_25401928_ChIP-Seq_HUVEC_Human1.98541845
20* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.93377890
21ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.92120587
22E2F7_22180533_ChIP-Seq_HELA_Human1.84382768
23ESR1_21235772_ChIP-Seq_MCF-7_Human1.84145027
24* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.81380880
25FOXM1_23109430_ChIP-Seq_U2OS_Human1.79834674
26RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.78744274
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.74665876
28ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.73748461
29KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.73199653
30* CDX2_20551321_ChIP-Seq_CACO-2_Human1.71882826
31* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.71427724
32* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.71427724
33MYC_19079543_ChIP-ChIP_MESCs_Mouse1.68765589
34ZNF263_19887448_ChIP-Seq_K562_Human1.68554921
35CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.66606042
36* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.66305114
37SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.64616262
38KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.64514873
39* ATF3_27146783_Chip-Seq_COLON_Human1.62342144
40AR_21909140_ChIP-Seq_LNCAP_Human1.62075543
41* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.61529587
42STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.59791113
43* RACK7_27058665_Chip-Seq_MCF-7_Human1.53410128
44* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.51682553
45HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.50504339
46* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.49678693
47ESR2_21235772_ChIP-Seq_MCF-7_Human1.49140914
48STAT6_21828071_ChIP-Seq_BEAS2B_Human1.48971708
49PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.47324641
50HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.45135235
51SALL4_18804426_ChIP-ChIP_XEN_Mouse1.43598081
52STAT3_1855785_ChIP-Seq_MESCs_Mouse1.43456568
53SOX2_20726797_ChIP-Seq_SW620_Human1.41984290
54THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.41392080
55MYC_18358816_ChIP-ChIP_MESCs_Mouse1.40929853
56KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.38704321
57KLF4_18555785_ChIP-Seq_MESCs_Mouse1.38060939
58* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.33474637
59CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32825962
60HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.30159530
61SOX2_18555785_ChIP-Seq_MESCs_Mouse1.30134616
62* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.29483588
63ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.29245975
64RXR_22158963_ChIP-Seq_LIVER_Mouse1.28966280
65KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.27997229
66PPAR_26484153_Chip-Seq_NCI-H1993_Human1.27874978
67* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.27802972
68ZFX_18555785_ChIP-Seq_MESCs_Mouse1.26945884
69MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.26683914
70* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.24267219
71* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.24119196
72TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24001532
73TP53_20018659_ChIP-ChIP_R1E_Mouse1.22939628
74FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.22663613
75* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.21820376
76* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.20904868
77NELFA_20434984_ChIP-Seq_ESCs_Mouse1.20640906
78TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18591203
79SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.18555527
80* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.17848176
81UBF1/2_26484160_Chip-Seq_HMECs_Human1.17760189
82TET1_21451524_ChIP-Seq_MESCs_Mouse1.17102707
83CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.16628714
84ERG_21242973_ChIP-ChIP_JURKAT_Human1.16278337
85* XRN2_22483619_ChIP-Seq_HELA_Human1.15764663
86P63_26484246_Chip-Seq_KERATINOCYTES_Human1.15103958
87* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.14547354
88ZFP281_18757296_ChIP-ChIP_E14_Mouse1.14006264
89RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.11190288
90* GATA6_25053715_ChIP-Seq_YYC3_Human1.10982747
91* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.10540858
92DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.10020337
93SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.08198984
94CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.08139604
95NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.07771417
96DCP1A_22483619_ChIP-Seq_HELA_Human1.06922040
97* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.06850809
98FOXO3_23340844_ChIP-Seq_DLD1_Human1.05417547
99ESR1_15608294_ChIP-ChIP_MCF-7_Human1.05388214
100* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.04741572
101TP53_22127205_ChIP-Seq_IMR90_Human1.04385558
102* CJUN_26792858_Chip-Seq_BT549_Human1.04153256
103CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04100621
104FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.03835937
105TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03113162
106* GATA4_25053715_ChIP-Seq_YYC3_Human1.02793140
107SRY_22984422_ChIP-ChIP_TESTIS_Rat1.02150588
108SOX9_24532713_ChIP-Seq_HFSC_Mouse1.02003104
109RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00823076
110* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.00562863
111ELK1_22589737_ChIP-Seq_MCF10A_Human1.00339104
112SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.99993662
113* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.99882705
114* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.97470851
115WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.96507596
116* BRD4_25478319_ChIP-Seq_HGPS_Human0.96176436
117MYC_19030024_ChIP-ChIP_MESCs_Mouse0.95993597
118* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.95802463
119RUNX1_27514584_Chip-Seq_MCF-7_Human0.94273087
120* SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.94071604
121* KDM2B_26808549_Chip-Seq_K562_Human0.93899641
122EP300_21415370_ChIP-Seq_HL-1_Mouse0.93725674
123CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.93588429
124* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.93398006
125WT1_19549856_ChIP-ChIP_CCG9911_Human0.93148043
126* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93071944
127* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92971402
128EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92627901
129P300_27058665_Chip-Seq_ZR-75-30cells_Human0.91680219
130LXR_22292898_ChIP-Seq_THP-1_Human0.90386922

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology3.65308861
2MP0004272_abnormal_basement_membrane3.20648747
3MP0003705_abnormal_hypodermis_morpholog3.17850163
4MP0010368_abnormal_lymphatic_system3.02912160
5MP0003941_abnormal_skin_development2.82533657
6MP0008438_abnormal_cutaneous_collagen2.75532696
7MP0010234_abnormal_vibrissa_follicle2.57482662
8MP0009053_abnormal_anal_canal2.37131591
9MP0001879_abnormal_lymphatic_vessel2.37046887
10MP0005275_abnormal_skin_tensile2.32989090
11MP0000537_abnormal_urethra_morphology2.29767673
12MP0005360_urolithiasis2.25045390
13MP0003279_aneurysm2.11816079
14MP0003566_abnormal_cell_adhesion2.09092859
15MP0005167_abnormal_blood-brain_barrier2.02924532
16MP0004858_abnormal_nervous_system1.93243791
17MP0006054_spinal_hemorrhage1.92995274
18MP0000579_abnormal_nail_morphology1.86595794
19MP0005503_abnormal_tendon_morphology1.81492109
20MP0005367_renal/urinary_system_phenotyp1.78359841
21MP0000516_abnormal_urinary_system1.78359841
22MP0000013_abnormal_adipose_tissue1.76943141
23MP0005623_abnormal_meninges_morphology1.73061722
24MP0000003_abnormal_adipose_tissue1.69174571
25MP0010352_gastrointestinal_tract_polyps1.68084681
26MP0000049_abnormal_middle_ear1.67447806
27MP0003385_abnormal_body_wall1.66771812
28MP0004185_abnormal_adipocyte_glucose1.66533684
29MP0000762_abnormal_tongue_morphology1.64072721
30MP0009780_abnormal_chondrocyte_physiolo1.62280176
31MP0009379_abnormal_foot_pigmentation1.60942869
32MP0005023_abnormal_wound_healing1.60178504
33MP0001661_extended_life_span1.57528632
34MP0005508_abnormal_skeleton_morphology1.53816974
35MP0002282_abnormal_trachea_morphology1.53028295
36MP0002796_impaired_skin_barrier1.49636064
37MP0002060_abnormal_skin_morphology1.48931758
38MP0003942_abnormal_urinary_system1.46216558
39MP0009384_cardiac_valve_regurgitation1.46200095
40MP0002249_abnormal_larynx_morphology1.45816579
41MP0009250_abnormal_appendicular_skeleto1.45004738
42MP0001958_emphysema1.43366284
43MP0003283_abnormal_digestive_organ1.41260156
44MP0000751_myopathy1.38920975
45MP0000534_abnormal_ureter_morphology1.36571551
46MP0000767_abnormal_smooth_muscle1.35079690
47MP0000733_abnormal_muscle_development1.32704627
48MP0003828_pulmonary_edema1.32637300
49MP0002932_abnormal_joint_morphology1.29450584
50MP0001849_ear_inflammation1.29149231
51MP0003878_abnormal_ear_physiology1.27860171
52MP0005377_hearing/vestibular/ear_phenot1.27860171
53MP0005501_abnormal_skin_physiology1.24547196
54MP0002089_abnormal_postnatal_growth/wei1.22913605
55MP0003453_abnormal_keratinocyte_physiol1.20278751
56MP0000750_abnormal_muscle_regeneration1.18144940
57MP0005083_abnormal_biliary_tract1.17274635
58MP0003937_abnormal_limbs/digits/tail_de1.16641708
59MP0005375_adipose_tissue_phenotype1.15168129
60MP0002697_abnormal_eye_size1.13836629
61MP0000566_synostosis1.12562665
62MP0003115_abnormal_respiratory_system1.11491438
63MP0002098_abnormal_vibrissa_morphology1.11195333
64MP0000678_abnormal_parathyroid_gland1.10299099
65MP0005409_darkened_coat_color1.09268996
66MP0003755_abnormal_palate_morphology1.07813356
67MP0002295_abnormal_pulmonary_circulatio1.07351951
68MP0002925_abnormal_cardiovascular_devel1.07069977
69MP0003123_paternal_imprinting1.07034906
70MP0005666_abnormal_adipose_tissue1.06819692
71MP0004233_abnormal_muscle_weight1.05474750
72MP0000467_abnormal_esophagus_morphology1.02898084
73MP0000163_abnormal_cartilage_morphology1.02015509
74MP0005330_cardiomyopathy1.01760010
75MP0009840_abnormal_foam_cell1.01650062
76MP0003091_abnormal_cell_migration1.00872129
77MP0003315_abnormal_perineum_morphology1.00637849
78MP0005076_abnormal_cell_differentiation0.98978639
79MP0004957_abnormal_blastocyst_morpholog0.98474747
80MP0004084_abnormal_cardiac_muscle0.96589495
81MP0002132_abnormal_respiratory_system0.95391450
82MP0003119_abnormal_digestive_system0.95320494
83MP0001614_abnormal_blood_vessel0.95278489
84MP0005670_abnormal_white_adipose0.94175687
85MP0008007_abnormal_cellular_replicative0.94027918
86MP0005197_abnormal_uvea_morphology0.93102128
87MP0004782_abnormal_surfactant_physiolog0.93038116
88MP0001299_abnormal_eye_distance/0.92947050
89MP0003567_abnormal_fetal_cardiomyocyte0.92764044
90MP0002111_abnormal_tail_morphology0.92007204
91MP0003693_abnormal_embryo_hatching0.91816098
92MP0003935_abnormal_craniofacial_develop0.91690967
93MP0002086_abnormal_extraembryonic_tissu0.91654468
94MP0005451_abnormal_body_composition0.90501296
95MP0002233_abnormal_nose_morphology0.89948107
96MP0010771_integument_phenotype0.89254869
97MP0005248_abnormal_Harderian_gland0.88882562
98MP0008932_abnormal_embryonic_tissue0.86568287
99MP0010630_abnormal_cardiac_muscle0.86412726
100MP0008004_abnormal_stomach_pH0.86356620
101MP0002092_abnormal_eye_morphology0.86274974
102MP0002009_preneoplasia0.86198562
103MP0004264_abnormal_extraembryonic_tissu0.85862877
104MP0006138_congestive_heart_failure0.85690733
105MP0003984_embryonic_growth_retardation0.84823961
106MP0002085_abnormal_embryonic_tissue0.83673384
107MP0002234_abnormal_pharynx_morphology0.83434561
108MP0000462_abnormal_digestive_system0.83417658
109MP0009278_abnormal_bone_marrow0.83221111
110MP0001216_abnormal_epidermal_layer0.83164737
111MP0002088_abnormal_embryonic_growth/wei0.83081808
112MP0001672_abnormal_embryogenesis/_devel0.82965535
113MP0005380_embryogenesis_phenotype0.82965535
114MP0004197_abnormal_fetal_growth/weight/0.81466042
115MP0002127_abnormal_cardiovascular_syste0.81395397
116MP0000627_abnormal_mammary_gland0.80757307
117MP0010678_abnormal_skin_adnexa0.80463055
118MP0000432_abnormal_head_morphology0.80352648
119MP0001730_embryonic_growth_arrest0.80088934
120MP0002896_abnormal_bone_mineralization0.79980066
121MP0001915_intracranial_hemorrhage0.79518827
122MP0002128_abnormal_blood_circulation0.79356487
123MP0001243_abnormal_dermal_layer0.79265481
124MP0005257_abnormal_intraocular_pressure0.78244842
125MP0004087_abnormal_muscle_fiber0.77849567
126MP0002084_abnormal_developmental_patter0.77628618
127MP0004883_abnormal_blood_vessel0.77355660
128MP0002877_abnormal_melanocyte_morpholog0.77256248
129MP0000477_abnormal_intestine_morphology0.76107427
130MP0000428_abnormal_craniofacial_morphol0.75690209
131MP0003111_abnormal_nucleus_morphology0.75055704
132MP0003191_abnormal_cellular_cholesterol0.74047944
133MP0003950_abnormal_plasma_membrane0.73972652
134MP0002108_abnormal_muscle_morphology0.73058758

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.66240000
2Premature rupture of membranes (HP:0001788)4.40865527
3Right ventricular cardiomyopathy (HP:0011663)3.82670122
4Shallow orbits (HP:0000586)3.22789566
5Atrophic scars (HP:0001075)3.15664550
6Cerebral aneurysm (HP:0004944)3.00491859
7Short hallux (HP:0010109)2.96887380
8Neonatal short-limb short stature (HP:0008921)2.92360957
9Abnormality of the 2nd finger (HP:0004100)2.83997728
10Spinal rigidity (HP:0003306)2.80098166
11Distal lower limb muscle weakness (HP:0009053)2.76765251
12Increased connective tissue (HP:0009025)2.75924137
13Aortic aneurysm (HP:0004942)2.75869651
14Aortic dissection (HP:0002647)2.70464600
15Fragile skin (HP:0001030)2.69823408
16Aplasia/Hypoplasia of the hallux (HP:0008362)2.68772526
17Aplasia involving bones of the upper limbs (HP:0009823)2.67885422
18Aplasia of the phalanges of the hand (HP:0009802)2.67885422
19Aplasia involving bones of the extremities (HP:0009825)2.67885422
20Hyperacusis (HP:0010780)2.63962169
21Elbow flexion contracture (HP:0002987)2.53079166
22Distal lower limb amyotrophy (HP:0008944)2.51969466
23Abnormality of dentin (HP:0010299)2.46871187
24Trismus (HP:0000211)2.44695430
25Fragile nails (HP:0001808)2.43394699
26Cardiovascular calcification (HP:0011915)2.42799243
27Partial duplication of thumb phalanx (HP:0009944)2.40386182
28Vascular calcification (HP:0004934)2.40129610
29Ankle contracture (HP:0006466)2.39526828
30Ileus (HP:0002595)2.38824317
31Osteolytic defects of the phalanges of the hand (HP:0009771)2.37857302
32Osteolytic defects of the hand bones (HP:0009699)2.37857302
33Abnormality of the distal phalanges of the toes (HP:0010182)2.37248602
34Achilles tendon contracture (HP:0001771)2.36792850
35Abnormality of the middle phalanges of the toes (HP:0010183)2.35184431
36Abnormal umbilical cord blood vessels (HP:0011403)2.32761172
37Single umbilical artery (HP:0001195)2.32761172
38Abnormality of the fetal cardiovascular system (HP:0010948)2.32761172
39Soft skin (HP:0000977)2.29715845
40Abnormality of the 1st metacarpal (HP:0010009)2.29669587
41Ventricular tachycardia (HP:0004756)2.26667049
42Woolly hair (HP:0002224)2.26371273
43Abnormality of the distal phalanx of the thumb (HP:0009617)2.25892779
44Abnormality of the Achilles tendon (HP:0005109)2.24156734
45Renal duplication (HP:0000075)2.22571063
46Alopecia of scalp (HP:0002293)2.22151312
47Abnormality of glutamine family amino acid metabolism (HP:0010902)2.19425602
48Onycholysis (HP:0001806)2.18548168
49Absent toe (HP:0010760)2.17606689
50Abnormality of carpal bone ossification (HP:0006257)2.17545759
51Pterygium (HP:0001059)2.17128570
52Abnormal vertebral ossification (HP:0100569)2.16654095
53Down-sloping shoulders (HP:0200021)2.15373206
54Milia (HP:0001056)2.12422206
55Bronchomalacia (HP:0002780)2.11834995
56Advanced eruption of teeth (HP:0006288)2.11285516
57Broad toe (HP:0001837)2.08850289
58Acanthosis nigricans (HP:0000956)2.07926645
59Broad metatarsal (HP:0001783)2.06446109
60Wormian bones (HP:0002645)2.05612710
61Stenosis of the external auditory canal (HP:0000402)2.05022035
62Difficulty climbing stairs (HP:0003551)2.03839600
63Congenital, generalized hypertrichosis (HP:0004540)2.03680930
64Vertebral compression fractures (HP:0002953)2.03369265
65Reduced subcutaneous adipose tissue (HP:0003758)2.03186351
66Cervical subluxation (HP:0003308)2.02573569
67Blue sclerae (HP:0000592)2.01647378
68Ulnar bowing (HP:0003031)2.01041440
69Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.99115008
70Arterial tortuosity (HP:0005116)1.98461335
71Abnormality of the umbilical cord (HP:0010881)1.96736316
72Pili torti (HP:0003777)1.96324257
73Peritonitis (HP:0002586)1.96118746
74Glossoptosis (HP:0000162)1.95946764
75Entropion (HP:0000621)1.95202576
76Selective tooth agenesis (HP:0001592)1.95179021
77Abnormal hemoglobin (HP:0011902)1.94201257
78Deviation of the hallux (HP:0010051)1.94066891
79Abnormality of the phalanges of the hallux (HP:0010057)1.92969501
80Overriding aorta (HP:0002623)1.92616348
81Flat acetabular roof (HP:0003180)1.92520169
82Distal upper limb amyotrophy (HP:0007149)1.91745172
83Upper limb amyotrophy (HP:0009129)1.91745172
84Follicular hyperkeratosis (HP:0007502)1.91667395
85Bladder diverticulum (HP:0000015)1.90913282
86Abnormality of the proximal phalanges of the hand (HP:0009834)1.90380122
87Fused cervical vertebrae (HP:0002949)1.90066057
88Broad face (HP:0000283)1.89722448
89Mesangial abnormality (HP:0001966)1.89441298
90Mildly elevated creatine phosphokinase (HP:0008180)1.89243611
91Broad hallux (HP:0010055)1.88968216
92Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.88479868
93Vertebral hypoplasia (HP:0008417)1.88479868
94Natal tooth (HP:0000695)1.88376336
95Abnormal hair laboratory examination (HP:0003328)1.88254487
96Rough bone trabeculation (HP:0100670)1.87751623
97Coronal craniosynostosis (HP:0004440)1.85936613
98Rectal prolapse (HP:0002035)1.85718263
99Hip contracture (HP:0003273)1.85100023
100Abnormality of the calcaneus (HP:0008364)1.84516054
101Short nail (HP:0001799)1.84325828
102Dilatation of the ascending aorta (HP:0005111)1.83327519
103Sparse lateral eyebrow (HP:0005338)1.82898262
104Insomnia (HP:0100785)1.82844183
105Short middle phalanx of finger (HP:0005819)1.82475470
106Scapular winging (HP:0003691)1.81633170
107Short phalanx of the thumb (HP:0009660)1.81290288
108Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.80941222
109Short 1st metacarpal (HP:0010034)1.80941222
110Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.80259858
111Partial duplication of the phalanx of hand (HP:0009999)1.79998658
112Vascular tortuosity (HP:0004948)1.79842301
113Abnormal delivery (HP:0001787)1.78385387
114Hemorrhage of the eye (HP:0011885)1.77697480
115Abnormality of the acetabulum (HP:0003170)1.77647477
116Nasolacrimal duct obstruction (HP:0000579)1.77312145
117Hallux valgus (HP:0001822)1.77066247
118Deviation of the thumb (HP:0009603)1.77056394
119Arnold-Chiari malformation (HP:0002308)1.76562751
120Abnormality of the phalanges of the 2nd finger (HP:0009541)1.76486950
121Insulin resistance (HP:0000855)1.75663624
122Neonatal death (HP:0003811)1.75364254
123Bowed forearm bones (HP:0003956)1.75352877
124Bowing of the arm (HP:0006488)1.75352877
125Deep venous thrombosis (HP:0002625)1.75300229
126Biconcave vertebral bodies (HP:0004586)1.75109966
127Breast hypoplasia (HP:0003187)1.74951132
128Lower limb amyotrophy (HP:0007210)1.74684014
129Short middle phalanx of the 5th finger (HP:0004220)1.74155651
130Deformed tarsal bones (HP:0008119)1.73690494
131Short humerus (HP:0005792)1.73567248
132Esophageal varix (HP:0002040)1.73102383
133Mesomelia (HP:0003027)1.72985588
134Asymmetry of the thorax (HP:0001555)1.72041266
135Type 1 muscle fiber predominance (HP:0003803)1.71581287
136Aplasia of the musculature (HP:0100854)1.71315277
137Aneurysm (HP:0002617)1.71308773
138Aplasia/hypoplasia of the humerus (HP:0006507)1.71147785
139Shawl scrotum (HP:0000049)1.70690480
140Muscle fiber splitting (HP:0003555)1.70440286
141Midface retrusion (HP:0011800)1.70227195
142Coxa vara (HP:0002812)1.70031689
143Pulmonary artery stenosis (HP:0004415)1.69760301
144Abnormal ossification of hand bones (HP:0005921)1.69733869
145Unilateral renal agenesis (HP:0000122)1.69267053
146Preaxial foot polydactyly (HP:0001841)1.69229949
147Wrist flexion contracture (HP:0001239)1.69023002
148Short clavicles (HP:0000894)1.66834707
149Mitral regurgitation (HP:0001653)1.66196692
150Turricephaly (HP:0000262)1.66167148
151Abnormality of the nasal septum (HP:0000419)1.65939320
152Breech presentation (HP:0001623)1.65868663
153Thin bony cortex (HP:0002753)1.65622286
154Small epiphyses (HP:0010585)1.65508123
155Ankyloglossia (HP:0010296)1.65434587
156Hypoplastic toenails (HP:0001800)1.65169265
157Syringomyelia (HP:0003396)1.63270518
158Spinal cord lesions (HP:0100561)1.63270518
159Proximal placement of thumb (HP:0009623)1.61750469
160Abnormality of complement system (HP:0005339)1.61315487
161Aplasia/Hypoplasia of the clavicles (HP:0006710)1.60687474
162Abnormalities of placenta or umbilical cord (HP:0001194)1.60066444

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB23.60630792
2TIE12.92251589
3LATS22.92020308
4EPHA22.71009485
5DDR22.61707293
6KDR2.52227142
7TRIB32.51803302
8ERN12.45857578
9TTN2.42055476
10TESK12.37597011
11MAP2K22.15949837
12NME22.12183004
13RIPK12.11861212
14PKN22.11775944
15SMG12.04525094
16MAP3K32.02971734
17ICK1.96616732
18PAK41.89168575
19MYLK1.85201390
20NTRK11.75860985
21TESK21.75423822
22PTK61.73590417
23SIK11.71793320
24PIM21.69836488
25TGFBR11.69627705
26FGFR41.69352326
27LATS11.66489132
28IRAK31.59930934
29STK38L1.59714167
30LIMK11.54903793
31RPS6KB21.50242339
32PAK21.48488453
33PDK21.45878614
34FER1.44873019
35PBK1.42993900
36LRRK21.38451060
37RPS6KA41.37727700
38PDGFRA1.32865882
39ILK1.31913587
40TGFBR21.31435179
41BUB11.31085175
42PRKG21.29514944
43PTK21.20134352
44STK101.19812059
45BRSK21.16075353
46BRSK11.15886004
47MOS1.15370549
48MAP2K31.13949666
49MET1.11648012
50ZAK1.10702296
51MAP3K81.07813264
52TRPM71.06635756
53EPHA31.06363834
54ABL21.05783367
55MAP3K101.05179197
56MAP3K111.02901648
57DMPK0.99590488
58MAP2K10.98996268
59LMTK20.98943105
60FLT30.96657100
61ARAF0.95066911
62SRPK10.93050774
63PTK2B0.92836801
64MST40.92079942
65MAPKAPK30.89596530
66MST1R0.89269794
67BCKDK0.88518309
68MELK0.87415475
69AURKB0.87279975
70CDK60.86319767
71PAK10.83720222
72SCYL20.83313268
73TAOK20.78234100
74PIK3CA0.77388386
75NEK20.74822538
76CDK120.74270864
77CDK70.70323979
78ROCK10.67300506
79FGFR10.66380875
80FRK0.65585711
81PRKCI0.64143190
82WEE10.64027209
83DYRK1B0.63706987
84AKT30.63639973
85DAPK30.63400616
86TTK0.61491996
87STK30.58679713
88BMX0.58592749
89ROCK20.57812060
90MAP3K120.56847827
91TAOK10.56719829
92MAP3K60.54968359
93MAPKAPK20.53597295
94ERBB30.53057668
95NUAK10.52934801
96MAPK110.52718318
97MTOR0.51301460
98VRK20.51175404
99PAK30.50268430
100MKNK10.50238672
101NEK10.50187081
102GRK10.49808568
103PRKD10.49692597
104NEK90.49012737
105ERBB40.48489546
106HIPK20.48141263
107STK390.48033595
108BRAF0.47629769
109CDK80.46449992
110MAPK150.45691926
111NME10.45144884
112DYRK30.44928096
113EPHB10.43586093
114PDPK10.42898494
115AKT20.42560834
116CAMK2G0.41101862
117PLK10.40659089
118ERBB20.40463777
119AURKA0.39225133
120TLK10.39193800
121PIM10.39188433
122NEK60.38442060
123RPS6KA20.37847465
124WNK40.37718704
125PDGFRB0.36168081
126EEF2K0.35929011
127CDK90.33828789
128STK40.31988251
129MAP3K20.31511099
130GSK3A0.31167614
131PRKD20.29285751
132PIK3CG0.29096936
133ALK0.28328635

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.48023485
2ECM-receptor interaction_Homo sapiens_hsa045122.61054011
3Bladder cancer_Homo sapiens_hsa052192.44056824
4Adherens junction_Homo sapiens_hsa045202.42933483
5Arginine biosynthesis_Homo sapiens_hsa002202.28982036
6Basal cell carcinoma_Homo sapiens_hsa052172.23069946
7Biosynthesis of amino acids_Homo sapiens_hsa012302.19825610
8* Hippo signaling pathway_Homo sapiens_hsa043902.15033767
9* TGF-beta signaling pathway_Homo sapiens_hsa043502.12108973
10Fructose and mannose metabolism_Homo sapiens_hsa000512.07388047
11Tight junction_Homo sapiens_hsa045302.06170686
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.05363759
13Glutathione metabolism_Homo sapiens_hsa004801.99140118
14Focal adhesion_Homo sapiens_hsa045101.98140934
15Sulfur metabolism_Homo sapiens_hsa009201.97209115
16Small cell lung cancer_Homo sapiens_hsa052221.93613177
17Proteoglycans in cancer_Homo sapiens_hsa052051.79469909
18p53 signaling pathway_Homo sapiens_hsa041151.76490184
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.71729379
20Leukocyte transendothelial migration_Homo sapiens_hsa046701.69692050
21Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.65278828
22Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.62662845
23Other glycan degradation_Homo sapiens_hsa005111.61118652
24Vitamin B6 metabolism_Homo sapiens_hsa007501.59380030
25Thyroid cancer_Homo sapiens_hsa052161.57988475
26* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.57886550
27Sulfur relay system_Homo sapiens_hsa041221.53352516
28Chemical carcinogenesis_Homo sapiens_hsa052041.52865180
29Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.49340527
30Phenylalanine metabolism_Homo sapiens_hsa003601.49039360
31Hedgehog signaling pathway_Homo sapiens_hsa043401.48915216
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.48527259
33AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.46761299
34Protein digestion and absorption_Homo sapiens_hsa049741.45688839
35MicroRNAs in cancer_Homo sapiens_hsa052061.42833865
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.37757757
37Pyruvate metabolism_Homo sapiens_hsa006201.31505676
38Cell cycle_Homo sapiens_hsa041101.26789726
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.22565178
40Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.21045143
41Pentose and glucuronate interconversions_Homo sapiens_hsa000401.19830294
42Amoebiasis_Homo sapiens_hsa051461.19674462
43N-Glycan biosynthesis_Homo sapiens_hsa005101.17552946
44Spliceosome_Homo sapiens_hsa030401.15705910
45Notch signaling pathway_Homo sapiens_hsa043301.15343342
46Mineral absorption_Homo sapiens_hsa049781.14199877
47Folate biosynthesis_Homo sapiens_hsa007901.13699802
48Tyrosine metabolism_Homo sapiens_hsa003501.10211457
49Dilated cardiomyopathy_Homo sapiens_hsa054141.09040425
50PI3K-Akt signaling pathway_Homo sapiens_hsa041511.07384122
51Pathways in cancer_Homo sapiens_hsa052001.06955858
52Melanoma_Homo sapiens_hsa052181.06199244
53Thyroid hormone synthesis_Homo sapiens_hsa049181.05887417
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02802564
55Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.01835334
56Chronic myeloid leukemia_Homo sapiens_hsa052201.01813238
57Glycosaminoglycan degradation_Homo sapiens_hsa005311.01634041
58Fat digestion and absorption_Homo sapiens_hsa049751.01329929
59HTLV-I infection_Homo sapiens_hsa051661.00921227
60DNA replication_Homo sapiens_hsa030301.00177306
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00041031
62Histidine metabolism_Homo sapiens_hsa003400.94965601
63Arachidonic acid metabolism_Homo sapiens_hsa005900.93204430
64HIF-1 signaling pathway_Homo sapiens_hsa040660.92882371
65Renin-angiotensin system_Homo sapiens_hsa046140.91449268
66Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.91154855
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.90492050
68RNA transport_Homo sapiens_hsa030130.90286454
69Prostate cancer_Homo sapiens_hsa052150.87147434
70Proteasome_Homo sapiens_hsa030500.86707638
71PPAR signaling pathway_Homo sapiens_hsa033200.83681329
72Bile secretion_Homo sapiens_hsa049760.83317244
73Complement and coagulation cascades_Homo sapiens_hsa046100.82761577
74Galactose metabolism_Homo sapiens_hsa000520.79970542
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79737060
76Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78794646
77Regulation of actin cytoskeleton_Homo sapiens_hsa048100.77741770
78Prion diseases_Homo sapiens_hsa050200.76793786
79Fatty acid degradation_Homo sapiens_hsa000710.76326154
80Wnt signaling pathway_Homo sapiens_hsa043100.76258891
81Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.75883726
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.75838062
83Mismatch repair_Homo sapiens_hsa034300.75585545
84Retinol metabolism_Homo sapiens_hsa008300.75000897
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74633677
86Systemic lupus erythematosus_Homo sapiens_hsa053220.72613996
87Selenocompound metabolism_Homo sapiens_hsa004500.71988549
88Apoptosis_Homo sapiens_hsa042100.71846288
89* Rap1 signaling pathway_Homo sapiens_hsa040150.70502687
90Viral myocarditis_Homo sapiens_hsa054160.69836576
91TNF signaling pathway_Homo sapiens_hsa046680.69833369
92Vitamin digestion and absorption_Homo sapiens_hsa049770.69623973
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64296999
94Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.63951838
95Shigellosis_Homo sapiens_hsa051310.62973473
96Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.62913789
97RNA polymerase_Homo sapiens_hsa030200.62137750
98Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62130431
99Axon guidance_Homo sapiens_hsa043600.61575813
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.61243013
101Toxoplasmosis_Homo sapiens_hsa051450.60191259
102Vibrio cholerae infection_Homo sapiens_hsa051100.59976525
103Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.59884906
104Pyrimidine metabolism_Homo sapiens_hsa002400.59419908
105Viral carcinogenesis_Homo sapiens_hsa052030.59225363
106Cyanoamino acid metabolism_Homo sapiens_hsa004600.58377612
107Alcoholism_Homo sapiens_hsa050340.58259990
108Melanogenesis_Homo sapiens_hsa049160.57741789
109Arginine and proline metabolism_Homo sapiens_hsa003300.57731331
110Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56206259
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56062570
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55281714
113Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54339366
114Base excision repair_Homo sapiens_hsa034100.54254941
115Lysine degradation_Homo sapiens_hsa003100.53732754
116One carbon pool by folate_Homo sapiens_hsa006700.53212072
117Insulin signaling pathway_Homo sapiens_hsa049100.51430768
118Fatty acid elongation_Homo sapiens_hsa000620.50017039
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.49891966
120Nucleotide excision repair_Homo sapiens_hsa034200.48465825
121Carbon metabolism_Homo sapiens_hsa012000.47956342
122Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47633879
123Glucagon signaling pathway_Homo sapiens_hsa049220.47286800
124Huntingtons disease_Homo sapiens_hsa050160.46757287
125Malaria_Homo sapiens_hsa051440.46692485
126AMPK signaling pathway_Homo sapiens_hsa041520.46064475
127Sphingolipid metabolism_Homo sapiens_hsa006000.45148142
128Salmonella infection_Homo sapiens_hsa051320.44575420
129Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44038508
130alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42810662
131Fatty acid metabolism_Homo sapiens_hsa012120.42718740
132Linoleic acid metabolism_Homo sapiens_hsa005910.41687726
133Starch and sucrose metabolism_Homo sapiens_hsa005000.41604801
134Pentose phosphate pathway_Homo sapiens_hsa000300.40094248
135Legionellosis_Homo sapiens_hsa051340.37916392
136Parkinsons disease_Homo sapiens_hsa050120.37515675
137Endometrial cancer_Homo sapiens_hsa052130.37510815
138Colorectal cancer_Homo sapiens_hsa052100.36849014
139Homologous recombination_Homo sapiens_hsa034400.36577957
140VEGF signaling pathway_Homo sapiens_hsa043700.34288041
141Steroid hormone biosynthesis_Homo sapiens_hsa001400.34077687
142Hepatitis C_Homo sapiens_hsa051600.34046229
143Cardiac muscle contraction_Homo sapiens_hsa042600.32809218
144RNA degradation_Homo sapiens_hsa030180.31536380

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »