ID2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the inhibitor of DNA binding family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the inhibitor of DNA binding family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A pseudogene of this gene is located on chromosome 3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.67994605
2cytidine metabolic process (GO:0046087)6.42579983
3cytidine catabolic process (GO:0006216)6.42579983
4cytidine deamination (GO:0009972)6.42579983
5regulation of activation of Janus kinase activity (GO:0010533)5.74125877
6regulation of chronic inflammatory response (GO:0002676)5.72914120
7neutrophil activation involved in immune response (GO:0002283)5.68453281
8pyrimidine ribonucleoside catabolic process (GO:0046133)5.62826064
9regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.56200305
10DNA deamination (GO:0045006)5.54101243
11cellular response to interleukin-15 (GO:0071350)5.30898336
12positive regulation of monocyte chemotaxis (GO:0090026)4.65045748
13positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.61581211
14positive regulation of natural killer cell mediated immunity (GO:0002717)4.57389896
15sequestering of actin monomers (GO:0042989)4.52974696
16regulation of isotype switching to IgG isotypes (GO:0048302)4.50147178
17positive regulation of cellular amide metabolic process (GO:0034250)4.33066488
18positive regulation of alpha-beta T cell proliferation (GO:0046641)4.33044542
19neutrophil activation (GO:0042119)4.24346795
20granulocyte activation (GO:0036230)4.20094820
21regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.14018092
22regulation of natural killer cell mediated immunity (GO:0002715)4.14018092
23leukocyte aggregation (GO:0070486)4.07058585
24response to interleukin-15 (GO:0070672)4.04898245
25positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)4.01072975
26cellular response to zinc ion (GO:0071294)4.00728424
27positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.97070519
28positive regulation of interferon-alpha production (GO:0032727)3.95658077
29negative regulation by host of viral transcription (GO:0043922)3.95471446
30T cell migration (GO:0072678)3.92146063
31positive regulation of interleukin-12 production (GO:0032735)3.91895747
32response to peptidoglycan (GO:0032494)3.90266980
33regulation of regulatory T cell differentiation (GO:0045589)3.88690331
34positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.81517115
35regulation of alpha-beta T cell proliferation (GO:0046640)3.75889160
36hydrogen peroxide biosynthetic process (GO:0050665)3.74817488
37positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.74348714
38eosinophil chemotaxis (GO:0048245)3.73689786
39regulation of leukocyte mediated cytotoxicity (GO:0001910)3.73602748
40regulation of interferon-alpha production (GO:0032647)3.72747111
41regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.72339394
42T-helper 1 type immune response (GO:0042088)3.70133344
43respiratory burst (GO:0045730)3.67325627
44superoxide anion generation (GO:0042554)3.64785396
45myeloid dendritic cell differentiation (GO:0043011)3.64422886
46activated T cell proliferation (GO:0050798)3.64076895
47positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.64019180
48regulation of lymphocyte chemotaxis (GO:1901623)3.58317717
49positive regulation by symbiont of host defense response (GO:0052509)3.54067066
50modulation by symbiont of host defense response (GO:0052031)3.54067066
51modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.54067066
52modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.54067066
53positive regulation by organism of defense response of other organism involved in symbiotic interact3.54067066
54modulation by symbiont of host immune response (GO:0052553)3.54067066
55immunoglobulin mediated immune response (GO:0016064)3.52272218
56myeloid dendritic cell activation (GO:0001773)3.50654594
57regulation of cell killing (GO:0031341)3.50315274
58positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.49090214
59positive regulation of cell killing (GO:0031343)3.48160635
60regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.47825241
61positive regulation of T-helper 1 type immune response (GO:0002827)3.46938663
62cellular defense response (GO:0006968)3.42758451
63natural killer cell mediated cytotoxicity (GO:0042267)3.42217038
64natural killer cell mediated immunity (GO:0002228)3.42217038
65interferon-gamma-mediated signaling pathway (GO:0060333)3.40110114
66regulation of interleukin-12 biosynthetic process (GO:0045075)3.39415857
67positive regulation of T-helper cell differentiation (GO:0045624)3.39012599
68regulation of monocyte chemotaxis (GO:0090025)3.38291662
69cellular response to type I interferon (GO:0071357)3.37677675
70type I interferon signaling pathway (GO:0060337)3.37677675
71regulation of memory T cell differentiation (GO:0043380)3.36052551
72positive regulation of type 2 immune response (GO:0002830)3.35752440
73regulation of hypersensitivity (GO:0002883)3.34269114
74defense response to protozoan (GO:0042832)3.33953347
75response to type I interferon (GO:0034340)3.32914159
76regulation of T-helper 1 cell differentiation (GO:0045625)3.32092825
77negative thymic T cell selection (GO:0045060)3.29864986
78lymphocyte chemotaxis (GO:0048247)3.29669029
79CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.29116059
80T cell differentiation involved in immune response (GO:0002292)3.28836470
81alpha-beta T cell differentiation involved in immune response (GO:0002293)3.28836470
82alpha-beta T cell activation involved in immune response (GO:0002287)3.28836470
83lipopolysaccharide-mediated signaling pathway (GO:0031663)3.26891363
84response to muramyl dipeptide (GO:0032495)3.25948365
85eosinophil migration (GO:0072677)3.24869018
86positive regulation of defense response to virus by host (GO:0002230)3.24856401
87regulation of T cell receptor signaling pathway (GO:0050856)3.23966841
88regulation of dendritic cell antigen processing and presentation (GO:0002604)3.23850664
89regulation of T cell chemotaxis (GO:0010819)3.23159299
90positive regulation of T cell chemotaxis (GO:0010820)3.23159299
91regulation of immunoglobulin secretion (GO:0051023)3.21432429
92negative regulation of interleukin-17 production (GO:0032700)3.20872664
93positive regulation of chemokine biosynthetic process (GO:0045080)3.20005020
94reactive oxygen species biosynthetic process (GO:1903409)3.18674101
95positive regulation of calcium-mediated signaling (GO:0050850)3.16684435
96positive regulation of antigen processing and presentation (GO:0002579)3.16571876
97monocyte chemotaxis (GO:0002548)3.15947441
98negative T cell selection (GO:0043383)3.14094346
99positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.13824206
100positive regulation of lymphocyte mediated immunity (GO:0002708)3.11773253
101regulation of T-helper 1 type immune response (GO:0002825)3.11590009
102positive regulation of interleukin-17 production (GO:0032740)3.10815789
103positive regulation of T cell migration (GO:2000406)3.09908181
104regulation of B cell receptor signaling pathway (GO:0050855)3.08978930
105positive regulation of lymphocyte migration (GO:2000403)3.06948197
106regulation of T cell mediated cytotoxicity (GO:0001914)3.06735390
107regulation of T-helper 2 cell differentiation (GO:0045628)3.06682189
108positive regulation of mast cell activation (GO:0033005)3.05015990
109cellular response to exogenous dsRNA (GO:0071360)3.02114461
110negative regulation of cell killing (GO:0031342)3.00928281
111negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.00928281
112myeloid cell activation involved in immune response (GO:0002275)2.99845455
113T-helper cell differentiation (GO:0042093)2.98432738
114CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.98432738
115positive regulation of interleukin-10 production (GO:0032733)2.98341322
116adaptation of signaling pathway (GO:0023058)2.98152948
117cellular response to interferon-beta (GO:0035458)2.97970766
118positive regulation of activated T cell proliferation (GO:0042104)2.96950756
119positive regulation of mast cell degranulation (GO:0043306)2.96576725
120positive regulation of mast cell activation involved in immune response (GO:0033008)2.96576725
121positive regulation of interleukin-2 production (GO:0032743)2.96350998
122positive regulation of interferon-gamma production (GO:0032729)2.95707660
123positive regulation of T cell mediated cytotoxicity (GO:0001916)2.95195042
124dendritic cell chemotaxis (GO:0002407)2.94863021
125behavioral response to nicotine (GO:0035095)2.94696074
126interferon-gamma production (GO:0032609)2.92934612
127macrophage chemotaxis (GO:0048246)2.92494328
128regulation of mononuclear cell migration (GO:0071675)2.92455307
129negative regulation of myeloid cell apoptotic process (GO:0033033)2.91514202
130microglial cell activation (GO:0001774)2.91417246
131regulation of chemokine biosynthetic process (GO:0045073)2.90417972
132B cell mediated immunity (GO:0019724)2.89720816
133response to protozoan (GO:0001562)2.89465730
134regulation of interleukin-12 production (GO:0032655)2.89242943
135cytolysis (GO:0019835)2.89033537
136leukocyte mediated cytotoxicity (GO:0001909)2.88959455
137regulation of T cell tolerance induction (GO:0002664)2.88957960
138production of molecular mediator involved in inflammatory response (GO:0002532)2.88457780
139positive regulation of B cell mediated immunity (GO:0002714)2.88288324
140positive regulation of immunoglobulin mediated immune response (GO:0002891)2.88288324
141lymphocyte migration (GO:0072676)2.87746023
142positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.87636061
143cellular response to interferon-gamma (GO:0071346)2.87474813
144regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.79796797
145chemokine-mediated signaling pathway (GO:0070098)2.76925137
146regulation of calcium-mediated signaling (GO:0050848)2.76146521
147positive regulation of leukocyte mediated immunity (GO:0002705)2.74802599
148regulation of response to tumor cell (GO:0002834)2.74694853
149positive regulation of response to tumor cell (GO:0002836)2.74694853
150positive regulation of immune response to tumor cell (GO:0002839)2.74694853
151regulation of immune response to tumor cell (GO:0002837)2.74694853
152positive T cell selection (GO:0043368)2.74526566
153negative regulation of interleukin-1 beta production (GO:0032691)2.70205292
154positive regulation of tolerance induction (GO:0002645)2.68774078
155positive regulation of humoral immune response (GO:0002922)2.68358952
156positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.68227557
157regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.67086479
158regulation of gamma-delta T cell differentiation (GO:0045586)2.64827501
159regulation of lymphocyte mediated immunity (GO:0002706)2.62092274
160alpha-beta T cell differentiation (GO:0046632)2.59466594
161negative regulation of T cell differentiation in thymus (GO:0033085)2.56420984
162fucose catabolic process (GO:0019317)2.56286005
163L-fucose metabolic process (GO:0042354)2.56286005
164L-fucose catabolic process (GO:0042355)2.56286005
165positive thymic T cell selection (GO:0045059)2.55326222
166positive regulation of T cell cytokine production (GO:0002726)2.55261152
167pyrimidine nucleoside catabolic process (GO:0046135)2.55159035
168regulation of inflammatory response to antigenic stimulus (GO:0002861)2.54787832
169mast cell activation (GO:0045576)2.53134520
170lymph node development (GO:0048535)2.52993391
171positive regulation of T cell mediated immunity (GO:0002711)2.51279995
172negative regulation of alpha-beta T cell activation (GO:0046636)2.51207038

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.79963125
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.69956049
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.32139054
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.73343312
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.53586615
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.47972943
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.67329837
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.47191647
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.29583188
10* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.26632534
11* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.19308025
12RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.06400028
13SMAD_19615063_ChIP-ChIP_OVARY_Human3.05162357
14STAT4_19710469_ChIP-ChIP_TH1__Mouse3.00275681
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.84226368
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.77870306
17NOTCH1_21737748_ChIP-Seq_TLL_Human2.71430020
18VDR_22108803_ChIP-Seq_LS180_Human2.65511935
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.42444565
20* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.36104791
21RUNX_20019798_ChIP-Seq_JUKART_Human2.15033206
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.12354379
23GABP_17652178_ChIP-ChIP_JURKAT_Human2.05158882
24ZNF274_21170338_ChIP-Seq_K562_Hela1.95200992
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.91939184
26MYB_21317192_ChIP-Seq_ERMYB_Mouse1.87850940
27VDR_24787735_ChIP-Seq_THP-1_Human1.86616908
28VDR_23849224_ChIP-Seq_CD4+_Human1.83066315
29PCGF2_27294783_Chip-Seq_NPCs_Mouse1.82998244
30* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.82155232
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.80103437
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.76776897
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.75876945
34EST1_17652178_ChIP-ChIP_JURKAT_Human1.74547341
35KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.71745497
36FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.68235697
37TAF15_26573619_Chip-Seq_HEK293_Human1.66064729
38* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.63251523
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61410915
40GATA1_22025678_ChIP-Seq_K562_Human1.60865396
41MYB_26560356_Chip-Seq_TH2_Human1.58362694
42NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.57094643
43NRF2_20460467_ChIP-Seq_MEFs_Mouse1.57094643
44SPI1_23547873_ChIP-Seq_NB4_Human1.54773216
45THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.51497957
46BCAT_22108803_ChIP-Seq_LS180_Human1.48088707
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.46667730
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46277345
49EGR1_23403033_ChIP-Seq_LIVER_Mouse1.42628872
50IGF1R_20145208_ChIP-Seq_DFB_Human1.41504114
51GBX2_23144817_ChIP-Seq_PC3_Human1.40467217
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40243284
53CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.38721947
54IKZF1_21737484_ChIP-ChIP_HCT116_Human1.38685787
55* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.38568490
56CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.38297326
57ER_23166858_ChIP-Seq_MCF-7_Human1.35892003
58TP53_22573176_ChIP-Seq_HFKS_Human1.35665934
59* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.35151156
60PU_27001747_Chip-Seq_BMDM_Mouse1.34176498
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34015678
62* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.33218451
63TCF4_22108803_ChIP-Seq_LS180_Human1.26405187
64SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.25202012
65FOXA1_21572438_ChIP-Seq_LNCaP_Human1.24786987
66TP63_17297297_ChIP-ChIP_HaCaT_Human1.24195832
67PRDM14_20953172_ChIP-Seq_ESCs_Human1.21162506
68FLI1_27457419_Chip-Seq_LIVER_Mouse1.20951863
69* CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.18403659
70EWS_26573619_Chip-Seq_HEK293_Human1.18374606
71CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.17963880
72* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17486369
73NANOG_19829295_ChIP-Seq_ESCs_Human1.17125801
74SOX2_19829295_ChIP-Seq_ESCs_Human1.17125801
75* GATA3_26560356_Chip-Seq_TH2_Human1.15648982
76CRX_20693478_ChIP-Seq_RETINA_Mouse1.14667349
77* FUS_26573619_Chip-Seq_HEK293_Human1.14052833
78MYB_26560356_Chip-Seq_TH1_Human1.13695495
79* GATA3_27048872_Chip-Seq_THYMUS_Human1.13303686
80* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.12303521
81* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11505203
82ZFP57_27257070_Chip-Seq_ESCs_Mouse1.10324057
83CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.09335785
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09240324
85CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08882715
86* PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.08590917
87OCT4_21477851_ChIP-Seq_ESCs_Mouse1.08258023
88PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07113192
89RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.06905149
90SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.05628489
91IRF1_19129219_ChIP-ChIP_H3396_Human1.05416890
92EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05228486
93PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04831682
94PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03440358
95* MAF_26560356_Chip-Seq_TH1_Human1.02247940
96BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01955688
97FOXA1_25329375_ChIP-Seq_VCAP_Human1.01943451
98FOXA1_27270436_Chip-Seq_PROSTATE_Human1.01943451
99FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01892257
100JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.01397844
101MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.99661250
102PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99479543
103TAF2_19829295_ChIP-Seq_ESCs_Human0.99272060
104EGR1_19032775_ChIP-ChIP_M12_Human0.99107241
105TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.98072416
106SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97792093
107* TP53_18474530_ChIP-ChIP_U2OS_Human0.97579362
108GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97505635
109TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97081769
110AR_20517297_ChIP-Seq_VCAP_Human0.96757627
111GATA3_21878914_ChIP-Seq_MCF-7_Human0.96499091
112GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.96433409
113CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.95151418
114GATA3_26560356_Chip-Seq_TH1_Human0.95127216
115FOXH1_21741376_ChIP-Seq_EPCs_Human0.94874780
116ELK1_19687146_ChIP-ChIP_HELA_Human0.93271557
117PIAS1_25552417_ChIP-Seq_VCAP_Human0.92741686
118OCT4_18555785_Chip-Seq_ESCs_Mouse0.92066840
119* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91761677
120* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91429787
121BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.91367466
122CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.89766529
123* RUNX1_22412390_ChIP-Seq_EML_Mouse0.88829238
124* SOX2_20726797_ChIP-Seq_SW620_Human0.87365697
125LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.85226718
126SPI1_23127762_ChIP-Seq_K562_Human0.84222845
127* P300_19829295_ChIP-Seq_ESCs_Human0.82204479
128EGR1_19374776_ChIP-ChIP_THP-1_Human0.82025937
129EZH2_27294783_Chip-Seq_NPCs_Mouse0.81540384
130CJUN_26792858_Chip-Seq_BT549_Human0.80786430
131FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.80077826
132ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.79298555
133NMYC_18555785_Chip-Seq_ESCs_Mouse0.79102299
134ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.78437040
135ELF1_17652178_ChIP-ChIP_JURKAT_Human0.77987793
136P53_22387025_ChIP-Seq_ESCs_Mouse0.76726590
137PU1_27457419_Chip-Seq_LIVER_Mouse0.76497339
138* SMRT_27268052_Chip-Seq_Bcells_Human0.76098667
139RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.75704387
140SUZ12_27294783_Chip-Seq_NPCs_Mouse0.73864004
141STAT3_18555785_Chip-Seq_ESCs_Mouse0.73592636
142EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.73429913
143LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.72812920
144E2F1_18555785_Chip-Seq_ESCs_Mouse0.72746758
145CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.72618931
146* VDR_24763502_ChIP-Seq_THP-1_Human0.72392377
147POU3F2_20337985_ChIP-ChIP_501MEL_Human0.71621677
148CMYC_18555785_Chip-Seq_ESCs_Mouse0.71354336
149GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.70856161
150NFE2_27457419_Chip-Seq_LIVER_Mouse0.69846989
151SUZ12_18555785_Chip-Seq_ESCs_Mouse0.69829342
152STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.69580925
153GATA2_21666600_ChIP-Seq_HMVEC_Human0.69567064
154RXR_22158963_ChIP-Seq_LIVER_Mouse0.67963070
155BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.66994983
156CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.66788316
157NANOG_18555785_Chip-Seq_ESCs_Mouse0.66329107
158* TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.65700514
159EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.65575366
160* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.65562112
161SOX2_18555785_Chip-Seq_ESCs_Mouse0.65462740
162RUNX1_27457419_Chip-Seq_LIVER_Mouse0.65000925
163EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.64190537

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.50897977
2MP0009785_altered_susceptibility_to4.71756164
3MP0005671_abnormal_response_to4.34162880
4MP0002148_abnormal_hypersensitivity_rea4.24136112
5MP0006082_CNS_inflammation3.85676678
6MP0003436_decreased_susceptibility_to3.46842580
7MP0000685_abnormal_immune_system3.36922738
8MP0005000_abnormal_immune_tolerance3.31026400
9MP0005025_abnormal_response_to3.11354491
10MP0002419_abnormal_innate_immunity2.97944905
11* MP0005387_immune_system_phenotype2.93955115
12* MP0001790_abnormal_immune_system2.93955115
13MP0003724_increased_susceptibility_to2.93623370
14MP0004510_myositis2.73359880
15MP0002452_abnormal_antigen_presenting2.57851214
16MP0002723_abnormal_immune_serum2.55509702
17MP0001800_abnormal_humoral_immune2.43934883
18MP0002006_tumorigenesis2.39262297
19* MP0001819_abnormal_immune_cell2.34085550
20MP0009764_decreased_sensitivity_to2.32112301
21* MP0002420_abnormal_adaptive_immunity2.28886481
22MP0001986_abnormal_taste_sensitivity2.24799690
23MP0001853_heart_inflammation2.19280591
24MP0002138_abnormal_hepatobiliary_system2.18476093
25MP0001501_abnormal_sleep_pattern2.07488546
26MP0004742_abnormal_vestibular_system2.07185104
27MP0008875_abnormal_xenobiotic_pharmacok1.99417228
28MP0002405_respiratory_system_inflammati1.99162917
29MP0002166_altered_tumor_susceptibility1.96319485
30MP0005310_abnormal_salivary_gland1.96063190
31MP0006072_abnormal_retinal_apoptosis1.82253301
32MP0001845_abnormal_inflammatory_respons1.80108878
33MP0003448_altered_tumor_morphology1.72785676
34MP0008469_abnormal_protein_level1.68718019
35MP0002102_abnormal_ear_morphology1.65982718
36MP0002254_reproductive_system_inflammat1.64533608
37MP0001533_abnormal_skeleton_physiology1.63482507
38MP0002163_abnormal_gland_morphology1.59732430
39MP0003303_peritoneal_inflammation1.59684034
40MP0003763_abnormal_thymus_physiology1.57793398
41MP0010155_abnormal_intestine_physiology1.57389190
42* MP0000716_abnormal_immune_system1.56115073
43MP0004947_skin_inflammation1.55062559
44MP0008872_abnormal_physiological_respon1.48590121
45MP0004782_abnormal_surfactant_physiolog1.45666930
46MP0000858_altered_metastatic_potential1.45382639
47MP0002998_abnormal_bone_remodeling1.45350442
48MP0000343_altered_response_to1.43457669
49MP0009333_abnormal_splenocyte_physiolog1.43186960
50MP0005058_abnormal_lysosome_morphology1.42376083
51MP0005464_abnormal_platelet_physiology1.42004634
52MP0005166_decreased_susceptibility_to1.41130291
53MP0002638_abnormal_pupillary_reflex1.39913353
54MP0001968_abnormal_touch/_nociception1.38785640
55MP0003186_abnormal_redox_activity1.38536904
56MP0009745_abnormal_behavioral_response1.36227428
57* MP0002398_abnormal_bone_marrow1.35256980
58MP0002009_preneoplasia1.32806700
59MP0003075_altered_response_to1.32804039
60MP0002736_abnormal_nociception_after1.28760210
61MP0004142_abnormal_muscle_tone1.23910837
62MP0005670_abnormal_white_adipose1.20551799
63MP0005551_abnormal_eye_electrophysiolog1.17737955
64MP0003011_delayed_dark_adaptation1.17441766
65MP0002277_abnormal_respiratory_mucosa1.15629454
66MP0002429_abnormal_blood_cell1.12873007
67MP0005367_renal/urinary_system_phenotyp1.11595240
68MP0000516_abnormal_urinary_system1.11595240
69MP0002876_abnormal_thyroid_physiology1.09743456
70MP0002139_abnormal_hepatobiliary_system1.08760787
71MP0000604_amyloidosis1.07975074
72MP0005377_hearing/vestibular/ear_phenot1.07943061
73MP0003878_abnormal_ear_physiology1.07943061
74MP0001486_abnormal_startle_reflex1.07867015
75MP0003690_abnormal_glial_cell1.06804845
76MP0004885_abnormal_endolymph1.04777359
77MP0000689_abnormal_spleen_morphology1.03651240
78MP0001919_abnormal_reproductive_system1.02502329
79MP0003195_calcinosis1.02249862
80MP0005253_abnormal_eye_physiology1.02041818
81MP0001346_abnormal_lacrimal_gland1.01029381
82MP0009763_increased_sensitivity_to0.99131611
83MP0005365_abnormal_bile_salt0.98765517
84* MP0002722_abnormal_immune_system0.98620553
85MP0001348_abnormal_lacrimal_gland0.98050841
86MP0010386_abnormal_urinary_bladder0.97399761
87MP0002272_abnormal_nervous_system0.96637960
88MP0001440_abnormal_grooming_behavior0.95834215
89MP0005646_abnormal_pituitary_gland0.95625205
90MP0002933_joint_inflammation0.89062272
91MP0009840_abnormal_foam_cell0.88801900
92MP0003252_abnormal_bile_duct0.86888720
93MP0005075_abnormal_melanosome_morpholog0.82906661
94MP0000465_gastrointestinal_hemorrhage0.81485967
95MP0005164_abnormal_response_to0.81220818
96MP0003191_abnormal_cellular_cholesterol0.80563752
97MP0009046_muscle_twitch0.79972039
98MP0004145_abnormal_muscle_electrophysio0.79902223
99MP0003300_gastrointestinal_ulcer0.79222611
100MP0003880_abnormal_central_pattern0.79161796
101MP0001485_abnormal_pinna_reflex0.78926286
102MP0005390_skeleton_phenotype0.78383713
103* MP0001502_abnormal_circadian_rhythm0.77197460
104MP0005167_abnormal_blood-brain_barrier0.77056966
105MP0003567_abnormal_fetal_cardiomyocyte0.76888563
106MP0005451_abnormal_body_composition0.76781475
107MP0002693_abnormal_pancreas_physiology0.76254736
108MP0008873_increased_physiological_sensi0.76234809
109MP0002064_seizures0.74935984
110MP0005084_abnormal_gallbladder_morpholo0.74626271
111MP0003137_abnormal_impulse_conducting0.74533964
112MP0005379_endocrine/exocrine_gland_phen0.74372180
113MP0002136_abnormal_kidney_physiology0.73881769
114MP0001764_abnormal_homeostasis0.73720590
115MP0003136_yellow_coat_color0.73242693
116MP0001666_abnormal_nutrient_absorption0.72413554
117MP0005171_absent_coat_pigmentation0.71864718
118MP0003866_abnormal_defecation0.71317251
119MP0000249_abnormal_blood_vessel0.68727278
120MP0004883_abnormal_blood_vessel0.67038854
121MP0008961_abnormal_basal_metabolism0.66996198
122MP0000372_irregular_coat_pigmentation0.66833475
123MP0005410_abnormal_fertilization0.65661975
124MP0001851_eye_inflammation0.64730777
125MP0003172_abnormal_lysosome_physiology0.64565619
126MP0004019_abnormal_vitamin_homeostasis0.62496637
127MP0001873_stomach_inflammation0.61254292
128MP0002295_abnormal_pulmonary_circulatio0.59703367
129MP0001542_abnormal_bone_strength0.59554523
130MP0009765_abnormal_xenobiotic_induced0.57340758
131MP0003795_abnormal_bone_structure0.55802308
132MP0002132_abnormal_respiratory_system0.54981628
133MP0005332_abnormal_amino_acid0.54015129
134MP0005584_abnormal_enzyme/coenzyme_acti0.53929549
135MP0005408_hypopigmentation0.52688257
136MP0005319_abnormal_enzyme/_coenzyme0.52239681
137MP0003045_fibrosis0.51798156
138MP0003183_abnormal_peptide_metabolism0.50612333
139MP0002090_abnormal_vision0.48690748
140MP0003828_pulmonary_edema0.48342492
141MP0000703_abnormal_thymus_morphology0.47591445
142MP0008260_abnormal_autophagy0.46968557
143MP0000015_abnormal_ear_pigmentation0.45821333
144MP0000767_abnormal_smooth_muscle0.45039111
145MP0000371_diluted_coat_color0.45016999
146MP0003453_abnormal_keratinocyte_physiol0.44379229

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)7.02509887
2Recurrent abscess formation (HP:0002722)6.56478607
3Increased IgM level (HP:0003496)6.10296026
4Recurrent bacterial skin infections (HP:0005406)5.85682205
5Recurrent gram-negative bacterial infections (HP:0005420)5.82844589
6Optic neuritis (HP:0100653)5.13789178
7Retrobulbar optic neuritis (HP:0100654)5.13789178
8Mediastinal lymphadenopathy (HP:0100721)4.98774384
9Orchitis (HP:0100796)4.84561728
10Abnormality of macrophages (HP:0004311)4.54426278
11Myositis (HP:0100614)4.51996411
12Stomatitis (HP:0010280)4.43807153
13Autoimmune thrombocytopenia (HP:0001973)4.17913170
14Gingivitis (HP:0000230)4.15781294
15Gastrointestinal infarctions (HP:0005244)4.10269630
16Elevated erythrocyte sedimentation rate (HP:0003565)3.98294644
17Recurrent skin infections (HP:0001581)3.97630005
18Chronic obstructive pulmonary disease (HP:0006510)3.87014467
19Obstructive lung disease (HP:0006536)3.87014467
20Hypoproteinemia (HP:0003075)3.85643859
21Recurrent fungal infections (HP:0002841)3.81760592
22Vasculitis (HP:0002633)3.74227164
23Vacuolated lymphocytes (HP:0001922)3.38859830
24Chronic mucocutaneous candidiasis (HP:0002728)3.35707060
25Recurrent cutaneous fungal infections (HP:0011370)3.35707060
26Pulmonary infiltrates (HP:0002113)3.34164871
27Abnormality of T cell number (HP:0011839)3.31251908
28Autoimmune hemolytic anemia (HP:0001890)3.17286805
29Basal ganglia calcification (HP:0002135)3.16416483
30Systemic lupus erythematosus (HP:0002725)3.10139186
31Renal cortical cysts (HP:0000803)3.07759375
32Keratoconjunctivitis sicca (HP:0001097)3.07703801
33Hemoptysis (HP:0002105)3.02677614
34Severe combined immunodeficiency (HP:0004430)3.01879690
35Abnormality of the renal cortex (HP:0011035)2.96765681
36Joint swelling (HP:0001386)2.92370303
37Meningitis (HP:0001287)2.91234184
38Acute necrotizing encephalopathy (HP:0006965)2.90402706
39Urticaria (HP:0001025)2.88460419
40Congenital stationary night blindness (HP:0007642)2.88144677
413-Methylglutaconic aciduria (HP:0003535)2.86379609
42Keratoconjunctivitis (HP:0001096)2.79282546
43Hypergammaglobulinemia (HP:0010702)2.77847349
44Arterial thrombosis (HP:0004420)2.75520889
45Combined immunodeficiency (HP:0005387)2.73720797
46Anorexia (HP:0002039)2.73107984
47Pancreatic cysts (HP:0001737)2.68138944
48Increased neuronal autofluorescent lipopigment (HP:0002074)2.65761825
49T lymphocytopenia (HP:0005403)2.64072045
50Leukocytosis (HP:0001974)2.60573406
51Gangrene (HP:0100758)2.59713054
52Hemiplegia (HP:0002301)2.59096173
53Abnormality of midbrain morphology (HP:0002418)2.57447254
54Molar tooth sign on MRI (HP:0002419)2.57447254
55Recurrent pneumonia (HP:0006532)2.53061350
56Tetraparesis (HP:0002273)2.52484055
57Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.51643842
58IgG deficiency (HP:0004315)2.51066164
59Febrile seizures (HP:0002373)2.50779661
60Mitochondrial inheritance (HP:0001427)2.50552093
61Periodontitis (HP:0000704)2.46699797
62Stomach cancer (HP:0012126)2.45467598
63Decreased electroretinogram (ERG) amplitude (HP:0000654)2.45145543
64Progressive macrocephaly (HP:0004481)2.44998859
65Abnormal mitochondria in muscle tissue (HP:0008316)2.41801227
66Abnormality of eosinophils (HP:0001879)2.41216608
67Thyroiditis (HP:0100646)2.40085291
68Recurrent viral infections (HP:0004429)2.39833053
69Chronic diarrhea (HP:0002028)2.39330660
70Abnormality of T cells (HP:0002843)2.36900221
71Increased cerebral lipofuscin (HP:0011813)2.36438688
72Joint hemorrhage (HP:0005261)2.32488623
73Encephalitis (HP:0002383)2.30819432
74Increased CSF lactate (HP:0002490)2.29760850
75Nephronophthisis (HP:0000090)2.28469832
76Abnormal albumin level (HP:0012116)2.27813589
77Hypoalbuminemia (HP:0003073)2.27813589
78Pustule (HP:0200039)2.26981763
79Abolished electroretinogram (ERG) (HP:0000550)2.23991474
80Prolonged neonatal jaundice (HP:0006579)2.21036702
81Axonal loss (HP:0003447)2.20068660
82Neoplasm of the tracheobronchial system (HP:0100552)2.18565869
83Acute encephalopathy (HP:0006846)2.16984751
84Poor head control (HP:0002421)2.13806770
85Eosinophilia (HP:0001880)2.13083610
86Conical tooth (HP:0000698)2.12946489
87Abnormal rod and cone electroretinograms (HP:0008323)2.11889166
88Abnormality of the renal medulla (HP:0100957)2.10974175
89Gaze-evoked nystagmus (HP:0000640)2.09626869
90Optic disc pallor (HP:0000543)2.08841342
91Type II lissencephaly (HP:0007260)2.07227747
92Glomerulopathy (HP:0100820)2.06993415
93Abnormality of the pericardium (HP:0001697)2.06985588
94Agammaglobulinemia (HP:0004432)2.06553209
95Abnormality of T cell physiology (HP:0011840)2.05453092
96Recurrent lower respiratory tract infections (HP:0002783)2.05422239
97Hypothermia (HP:0002045)2.03645479
98Prostate neoplasm (HP:0100787)2.00420968
99Glomerulonephritis (HP:0000099)1.98500280
100Focal motor seizures (HP:0011153)1.98061250
101Myocardial infarction (HP:0001658)1.97007947
102Arthralgia (HP:0002829)1.96044420
103Abnormality of glycolipid metabolism (HP:0010969)1.95798271
104Abnormality of liposaccharide metabolism (HP:0010968)1.95798271
105Abnormality of glycosphingolipid metabolism (HP:0004343)1.95798271
106Microretrognathia (HP:0000308)1.95426089
107Gingival bleeding (HP:0000225)1.94927510
108Pulmonary embolism (HP:0002204)1.93115179
109True hermaphroditism (HP:0010459)1.93091185
110Large for gestational age (HP:0001520)1.92132821
111Thick nail (HP:0001805)1.92031869
112Abnormality of alanine metabolism (HP:0010916)1.92009775
113Hyperalaninemia (HP:0003348)1.92009775
114Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.92009775
115Vertebral compression fractures (HP:0002953)1.91896509
116Amyloidosis (HP:0011034)1.91833252
117Premature loss of primary teeth (HP:0006323)1.91351626
118Split foot (HP:0001839)1.90988783
119Abnormality of the anterior horn cell (HP:0006802)1.89748448
120Degeneration of anterior horn cells (HP:0002398)1.89748448
121Abnormality of cells of the lymphoid lineage (HP:0012140)1.89714447
122Recurrent bronchitis (HP:0002837)1.89382970
123Abnormality of the pleura (HP:0002103)1.89143972
124Oligodactyly (hands) (HP:0001180)1.88321861
125Cheilitis (HP:0100825)1.87686209
126Abnormal delayed hypersensitivity skin test (HP:0002963)1.87473802
127Interstitial pulmonary disease (HP:0006530)1.86838887
128Bone pain (HP:0002653)1.86173467
129Cerebral edema (HP:0002181)1.85571201
130Chronic otitis media (HP:0000389)1.83737790
131Aplasia/hypoplasia of the uterus (HP:0008684)1.83219599
132Congenital, generalized hypertrichosis (HP:0004540)1.82766168
133Cellulitis (HP:0100658)1.82690131
134Abnormality of the phalanges of the 2nd finger (HP:0009541)1.82448982
135IgA deficiency (HP:0002720)1.82398648
136Atonic seizures (HP:0010819)1.79872259
137Purpura (HP:0000979)1.79667135
138Increased hepatocellular lipid droplets (HP:0006565)1.78254959
139Sepsis (HP:0100806)1.78225217
140Medial flaring of the eyebrow (HP:0010747)1.78114631
141Bilateral sensorineural hearing impairment (HP:0008619)1.77610083
142Concave nail (HP:0001598)1.77147792
143Lipid accumulation in hepatocytes (HP:0006561)1.76476944
144Nephritis (HP:0000123)1.76056307
145Hepatocellular necrosis (HP:0001404)1.75851473
146Lymphopenia (HP:0001888)1.74943312
147Granulocytopenia (HP:0001913)1.73508980
148Mutism (HP:0002300)1.73034358
149Constricted visual fields (HP:0001133)1.72797253
150Pancreatitis (HP:0001733)1.72762818
151Polyneuropathy (HP:0001271)1.72161189
152Abnormality of the prostate (HP:0008775)1.72016023
153Increased intramyocellular lipid droplets (HP:0012240)1.71189793
154Hepatosplenomegaly (HP:0001433)1.70553576
155Osteomyelitis (HP:0002754)1.69276436
156Alveolar cell carcinoma (HP:0006519)1.69134959
157Attenuation of retinal blood vessels (HP:0007843)1.66931796

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K145.31850530
2RIPK43.75355672
3TXK3.48667867
4PBK3.37440490
5TBK13.35579035
6MAP3K123.25612803
7TSSK63.10620897
8IRAK43.01500417
9IKBKE2.68967654
10BMPR22.65467460
11TLK12.63054006
12JAK32.58808937
13IKBKB2.57350221
14BLK2.44044626
15TYK22.33430499
16MST42.12450349
17WNK42.00850746
18EIF2AK31.97592186
19IRAK31.95329257
20NEK91.94498476
21JAK11.91739260
22BCKDK1.87667071
23MAP4K21.84925273
24MAP3K131.84297908
25STK391.81428640
26PIM21.80920135
27SRPK11.65252518
28TESK11.64560139
29CHUK1.63448032
30SIK31.58951401
31MAP4K11.50847522
32ZAP701.48999255
33TRIM281.39669090
34ERBB31.35279743
35GRK11.31316928
36PDK21.30184707
37BCR1.26425176
38FES1.23577590
39SYK1.22159932
40STK241.19615637
41PINK11.14670162
42LCK1.10887888
43LYN1.08691096
44YES11.06727909
45KDR1.05525432
46KIT1.02016720
47AKT31.01939729
48MYLK1.01374548
49ABL20.96862557
50FGFR30.95525603
51FGFR40.94976298
52CSK0.94329769
53PIK3CA0.93973838
54CSNK1A1L0.91464980
55PIM10.91205720
56ZAK0.91166632
57BTK0.90820566
58PRKCQ0.89689596
59ARAF0.88644641
60ADRBK20.87497838
61BMX0.87246229
62BMPR1B0.85950885
63CSNK1G30.85882344
64WNK30.84074281
65EIF2AK20.83402872
66PRKCD0.82479393
67HCK0.81227228
68EPHA30.81101674
69CASK0.79777576
70OXSR10.77264102
71JAK20.77182217
72TEC0.77072669
73IRAK20.76424572
74IRAK10.76101561
75CSNK1G20.76042776
76NUAK10.75328049
77MAP2K70.72110677
78MST1R0.71962541
79CAMKK20.71859255
80RPS6KA40.71468804
81GRK70.71124833
82MAPK130.69735920
83CSNK1G10.69608407
84VRK10.69336958
85MUSK0.64913599
86ITK0.63959932
87ERBB40.63850408
88PAK30.63776224
89TNK20.63097776
90FRK0.62162254
91TESK20.61920173
92ABL10.60877976
93LIMK10.60873724
94NME20.59321517
95GRK50.58919791
96MAPK150.58455361
97MAP3K50.57188940
98DAPK20.56568174
99MATK0.55630465
100FGFR10.54793245
101INSRR0.53915338
102MARK30.53899551
103DAPK30.53698427
104STK40.53522020
105PRKCE0.52851035
106TAOK30.51569222
107TAOK20.48828828
108PAK60.48246416
109PLK20.47899745
110PRKCG0.47653000
111CAMK2A0.46910953
112NEK60.46540253
113MAP2K20.45705973
114WEE10.42700821
115PRKCA0.40988064
116IGF1R0.40484049
117MAP2K60.40002202
118TRPM70.39595164
119PDK10.38533337
120FGR0.38504971
121CSF1R0.38187276
122MAP3K40.38170242
123ACVR1B0.37615184
124MOS0.36868900
125PRKACA0.36415807
126RPS6KA50.35396718
127PRKCH0.35162140
128CAMK2D0.35020536
129CSNK1A10.33789419
130MAP3K110.32713496
131MAPKAPK20.32137743
132FYN0.28590507
133PIK3CG0.28071208
134NLK0.27186304
135EGFR0.26976072
136INSR0.26867164
137DAPK10.26167537
138STK30.25514610
139ERN10.23466372
140PKN10.22735990
141MAP3K30.22339081
142EPHB10.22004586
143MAP3K10.20493942
144SGK20.18845243
145GRK60.17772917
146SIK20.17126076
147SRC0.17122207

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053325.15695722
2Allograft rejection_Homo sapiens_hsa053304.43730804
3Type I diabetes mellitus_Homo sapiens_hsa049402.95010223
4Leishmaniasis_Homo sapiens_hsa051402.85953098
5Autoimmune thyroid disease_Homo sapiens_hsa053202.67403899
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.62783894
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.53889672
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.49878704
9Toll-like receptor signaling pathway_Homo sapiens_hsa046202.48825672
10Rheumatoid arthritis_Homo sapiens_hsa053232.42947844
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.33611465
12Asthma_Homo sapiens_hsa053102.32273840
13Protein export_Homo sapiens_hsa030602.31843141
14Legionellosis_Homo sapiens_hsa051342.27161559
15Staphylococcus aureus infection_Homo sapiens_hsa051502.24822963
16Nitrogen metabolism_Homo sapiens_hsa009102.22815327
17Measles_Homo sapiens_hsa051622.11350802
18Malaria_Homo sapiens_hsa051442.05474470
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.01755162
20NOD-like receptor signaling pathway_Homo sapiens_hsa046212.00293685
21Primary immunodeficiency_Homo sapiens_hsa053401.93249773
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.92793143
23Pertussis_Homo sapiens_hsa051331.83489462
24Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.75535223
25African trypanosomiasis_Homo sapiens_hsa051431.72600538
26Osteoclast differentiation_Homo sapiens_hsa043801.72187769
27Tuberculosis_Homo sapiens_hsa051521.71881618
28Viral myocarditis_Homo sapiens_hsa054161.67223271
29Parkinsons disease_Homo sapiens_hsa050121.66458039
30TNF signaling pathway_Homo sapiens_hsa046681.63066659
31Antigen processing and presentation_Homo sapiens_hsa046121.56837302
32Caffeine metabolism_Homo sapiens_hsa002321.51826167
33Influenza A_Homo sapiens_hsa051641.48155393
34Salmonella infection_Homo sapiens_hsa051321.45696183
35Chemokine signaling pathway_Homo sapiens_hsa040621.41803263
36Phagosome_Homo sapiens_hsa041451.36396162
37Sulfur metabolism_Homo sapiens_hsa009201.35677172
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.31406196
39Lysosome_Homo sapiens_hsa041421.30896675
40Hematopoietic cell lineage_Homo sapiens_hsa046401.30430495
41Circadian rhythm_Homo sapiens_hsa047101.29483330
42Toxoplasmosis_Homo sapiens_hsa051451.27779600
43Collecting duct acid secretion_Homo sapiens_hsa049661.26109397
44Jak-STAT signaling pathway_Homo sapiens_hsa046301.24488293
45Herpes simplex infection_Homo sapiens_hsa051681.19932336
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.19631925
47T cell receptor signaling pathway_Homo sapiens_hsa046601.16162631
48Phototransduction_Homo sapiens_hsa047441.15117935
49Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.14496538
50Apoptosis_Homo sapiens_hsa042101.13296803
51Shigellosis_Homo sapiens_hsa051311.06065054
52Proteasome_Homo sapiens_hsa030501.04705395
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03295376
54Linoleic acid metabolism_Homo sapiens_hsa005911.02737242
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.97332349
56RNA polymerase_Homo sapiens_hsa030200.93865285
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.89330471
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.87815834
59B cell receptor signaling pathway_Homo sapiens_hsa046620.87535125
60Tryptophan metabolism_Homo sapiens_hsa003800.83912358
61Pentose and glucuronate interconversions_Homo sapiens_hsa000400.82150479
62Huntingtons disease_Homo sapiens_hsa050160.78790452
63Maturity onset diabetes of the young_Homo sapiens_hsa049500.78528476
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.78027718
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76997022
66Leukocyte transendothelial migration_Homo sapiens_hsa046700.76869784
67Regulation of autophagy_Homo sapiens_hsa041400.76797696
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75871950
69Basal transcription factors_Homo sapiens_hsa030220.75384197
70Hepatitis B_Homo sapiens_hsa051610.74126442
71Hepatitis C_Homo sapiens_hsa051600.71881744
72Complement and coagulation cascades_Homo sapiens_hsa046100.71002563
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70629520
74Butanoate metabolism_Homo sapiens_hsa006500.69600040
75Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.67926443
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66234325
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64488254
78Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63335094
79Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.62427249
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61743995
81Prion diseases_Homo sapiens_hsa050200.59753852
82Nicotine addiction_Homo sapiens_hsa050330.58697629
83Other glycan degradation_Homo sapiens_hsa005110.58531847
84Cardiac muscle contraction_Homo sapiens_hsa042600.57006692
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56708242
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55754844
87RNA degradation_Homo sapiens_hsa030180.53440212
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53243212
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52502502
90Amoebiasis_Homo sapiens_hsa051460.52041675
91Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45237032
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43601070
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42967478
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42805799
95GABAergic synapse_Homo sapiens_hsa047270.41813925
96Propanoate metabolism_Homo sapiens_hsa006400.41455175
97Morphine addiction_Homo sapiens_hsa050320.40335877
98Steroid biosynthesis_Homo sapiens_hsa001000.40288684
99Peroxisome_Homo sapiens_hsa041460.39469174
100Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.37767696
101Prolactin signaling pathway_Homo sapiens_hsa049170.37370119
102Mineral absorption_Homo sapiens_hsa049780.36797174
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36616543
104Fatty acid degradation_Homo sapiens_hsa000710.36189147
105Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.34957642
106Cysteine and methionine metabolism_Homo sapiens_hsa002700.33482576
107Vibrio cholerae infection_Homo sapiens_hsa051100.33367987
108Oxidative phosphorylation_Homo sapiens_hsa001900.32155351
109Primary bile acid biosynthesis_Homo sapiens_hsa001200.26781291
110Taste transduction_Homo sapiens_hsa047420.25125150
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24808827
112Phenylalanine metabolism_Homo sapiens_hsa003600.24531589
113Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.23483623
114Steroid hormone biosynthesis_Homo sapiens_hsa001400.22506650
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.22243787
116Epstein-Barr virus infection_Homo sapiens_hsa051690.22087231
117Pancreatic cancer_Homo sapiens_hsa052120.21895490
118Glycosaminoglycan degradation_Homo sapiens_hsa005310.18211415
119Platelet activation_Homo sapiens_hsa046110.18192157
120Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.17273633
121Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.15512291
122Acute myeloid leukemia_Homo sapiens_hsa052210.15219553
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.13773095
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.11489511
125Adherens junction_Homo sapiens_hsa045200.10547575
126Renin-angiotensin system_Homo sapiens_hsa046140.09531260
127Alzheimers disease_Homo sapiens_hsa050100.08632784
128Retinol metabolism_Homo sapiens_hsa008300.08131694
129HTLV-I infection_Homo sapiens_hsa051660.07687607
130Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.05939158
131Synaptic vesicle cycle_Homo sapiens_hsa047210.05397089
132Vitamin digestion and absorption_Homo sapiens_hsa049770.04102073
133* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.03284466
134Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.03085890
135PPAR signaling pathway_Homo sapiens_hsa033200.03056625
136Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.02482102
137Chemical carcinogenesis_Homo sapiens_hsa052040.02205199
138Fatty acid biosynthesis_Homo sapiens_hsa000610.00980190

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