ID3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with other HLH proteins. However, the encoded protein lacks a basic DNA-binding domain and therefore inhibits the DNA binding of any HLH protein with which it interacts. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lymph vessel development (GO:0001945)5.36873965
2epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)4.87430614
3endothelium development (GO:0003158)4.40504559
4endocardial cushion morphogenesis (GO:0003203)4.36532585
5endothelial cell morphogenesis (GO:0001886)4.35816330
6cell proliferation involved in metanephros development (GO:0072203)4.35411080
7mesenchyme morphogenesis (GO:0072132)4.30255798
8cell proliferation involved in kidney development (GO:0072111)4.29946110
9Notch signaling involved in heart development (GO:0061314)4.13383326
10chondrocyte proliferation (GO:0035988)3.95541342
11ribosomal small subunit biogenesis (GO:0042274)3.79043496
12cardiac epithelial to mesenchymal transition (GO:0060317)3.78575633
13G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.75692127
14lymphangiogenesis (GO:0001946)3.70461123
15vascular endothelial growth factor signaling pathway (GO:0038084)3.64689113
16regulation of endothelial cell differentiation (GO:0045601)3.63617705
17viral transcription (GO:0019083)3.63551879
18cell migration involved in heart development (GO:0060973)3.63400291
19atrioventricular valve morphogenesis (GO:0003181)3.62399251
20mesenchymal cell proliferation (GO:0010463)3.60658912
21positive regulation of endothelial cell differentiation (GO:0045603)3.58786321
22establishment of integrated proviral latency (GO:0075713)3.57373982
23lung vasculature development (GO:0060426)3.55527458
24endothelial cell differentiation (GO:0045446)3.54321140
25glomerular basement membrane development (GO:0032836)3.54240776
26neuron projection extension involved in neuron projection guidance (GO:1902284)3.52648621
27axon extension involved in axon guidance (GO:0048846)3.52648621
28translational termination (GO:0006415)3.48839799
29cell surface receptor signaling pathway involved in heart development (GO:0061311)3.48812745
30endothelial tube morphogenesis (GO:0061154)3.47457657
31morphogenesis of an endothelium (GO:0003159)3.47457657
32outer ear morphogenesis (GO:0042473)3.46816460
33paraxial mesoderm development (GO:0048339)3.45253003
34protein heterotrimerization (GO:0070208)3.42870843
35cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.35915528
36ribosomal small subunit assembly (GO:0000028)3.35798427
37positive regulation of epithelial to mesenchymal transition (GO:0010718)3.35552414
38collagen fibril organization (GO:0030199)3.32898940
39mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.31850376
40blood vessel maturation (GO:0001955)3.31164310
41ventricular cardiac muscle cell development (GO:0055015)3.28715353
42heart valve morphogenesis (GO:0003179)3.26624089
43metanephric mesenchyme development (GO:0072075)3.26242399
44wound healing, spreading of epidermal cells (GO:0035313)3.24674026
45protein complex localization (GO:0031503)3.24261784
46glomerulus development (GO:0032835)3.24081211
47kidney mesenchyme development (GO:0072074)3.23167188
48SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.22806769
49establishment of protein localization to mitochondrial membrane (GO:0090151)3.19317623
50heart valve formation (GO:0003188)3.18911112
51regulation of vasculogenesis (GO:2001212)3.18828499
52mesenchymal cell development (GO:0014031)3.18515414
53positive regulation of BMP signaling pathway (GO:0030513)3.17594744
54maturation of SSU-rRNA (GO:0030490)3.17367415
55regulation of heart morphogenesis (GO:2000826)3.17242821
56cotranslational protein targeting to membrane (GO:0006613)3.16623404
57cellular protein complex localization (GO:0034629)3.16525642
58retina vasculature morphogenesis in camera-type eye (GO:0061299)3.16490584
59protein targeting to ER (GO:0045047)3.13442542
60dermatan sulfate biosynthetic process (GO:0030208)3.08928064
61neural crest cell development (GO:0014032)3.08611028
62basement membrane organization (GO:0071711)3.08508406
63protein maturation by protein folding (GO:0022417)3.08437838
64positive regulation of endothelial cell apoptotic process (GO:2000353)3.05840864
65glomerular filtration (GO:0003094)3.03340115
66positive regulation of astrocyte differentiation (GO:0048711)3.01656508
67convergent extension (GO:0060026)3.01340465
68translational elongation (GO:0006414)3.00128112
69proteasome assembly (GO:0043248)2.99344233
70establishment of protein localization to endoplasmic reticulum (GO:0072599)2.98754148
71artery development (GO:0060840)2.98071066
72lung morphogenesis (GO:0060425)2.97523056
73negative regulation of chondrocyte differentiation (GO:0032331)2.96667672
74mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.95560929
75establishment of viral latency (GO:0019043)2.95415750
76smooth muscle tissue development (GO:0048745)2.95065674
77regulation of integrin-mediated signaling pathway (GO:2001044)2.95045758
78vasculogenesis (GO:0001570)2.94976741
79vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.94524467
80CENP-A containing nucleosome assembly (GO:0034080)2.94215062
81blood vessel endothelial cell migration (GO:0043534)2.93751139
82radial glial cell differentiation (GO:0060019)2.93557199
83cell adhesion mediated by integrin (GO:0033627)2.93164341
84DNA strand elongation involved in DNA replication (GO:0006271)2.93139449
85DNA strand elongation (GO:0022616)2.92729922
86chromatin remodeling at centromere (GO:0031055)2.92435924
87positive regulation of cartilage development (GO:0061036)2.92068725
88dermatan sulfate metabolic process (GO:0030205)2.91847822
89trabecula morphogenesis (GO:0061383)2.91758520
90protein localization to endoplasmic reticulum (GO:0070972)2.91427677
91nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.89765718
92heart trabecula morphogenesis (GO:0061384)2.88681731
93wound healing, spreading of cells (GO:0044319)2.84692813
94bone trabecula formation (GO:0060346)2.84162259
95ribosomal large subunit biogenesis (GO:0042273)2.82996572
96blood vessel morphogenesis (GO:0048514)2.81104317
97epithelial to mesenchymal transition (GO:0001837)2.80438694
98renal filtration (GO:0097205)2.79844287
99regulation of tight junction assembly (GO:2000810)2.79695057
100chaperone-mediated protein transport (GO:0072321)2.78903175
101translational initiation (GO:0006413)2.78685688
102planar cell polarity pathway involved in neural tube closure (GO:0090179)2.78634410
103aorta morphogenesis (GO:0035909)2.78547686
104middle ear morphogenesis (GO:0042474)2.77862854
105regulation of mesenchymal cell apoptotic process (GO:2001053)2.77139121
106cellular protein complex disassembly (GO:0043624)2.75062932
107spliceosomal snRNP assembly (GO:0000387)2.74966523
108negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.74857115
109viral life cycle (GO:0019058)2.74609238
110negative regulation of ligase activity (GO:0051352)2.72695695
111negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.72695695
112artery morphogenesis (GO:0048844)2.72613006
113ATP synthesis coupled proton transport (GO:0015986)2.71976046
114energy coupled proton transport, down electrochemical gradient (GO:0015985)2.71976046
115positive regulation of extracellular matrix organization (GO:1903055)2.71851185
116mitotic metaphase plate congression (GO:0007080)2.71642067
117negative regulation of cell fate specification (GO:0009996)2.71019428
118cell migration involved in sprouting angiogenesis (GO:0002042)2.70234693
119positive regulation of vasculogenesis (GO:2001214)2.69938344
120protein localization to kinetochore (GO:0034501)2.69601191
121heterochromatin organization (GO:0070828)2.69186536
122lateral sprouting from an epithelium (GO:0060601)2.67674017
123embryonic skeletal joint morphogenesis (GO:0060272)2.67289994
124mitotic nuclear envelope reassembly (GO:0007084)2.67220683
125nuclear envelope reassembly (GO:0031468)2.67220683
126L-serine metabolic process (GO:0006563)2.66760474
127stem cell development (GO:0048864)2.66465887
128ventricular trabecula myocardium morphogenesis (GO:0003222)2.65369155
129protein localization to chromosome, centromeric region (GO:0071459)2.65307453
130regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.63304180
131regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.63258532
132positive regulation of stem cell differentiation (GO:2000738)2.61911960
133regulation of SMAD protein import into nucleus (GO:0060390)2.61582914
134nucleobase-containing small molecule interconversion (GO:0015949)2.61369278
135trabecula formation (GO:0060343)2.60099573
136branching involved in salivary gland morphogenesis (GO:0060445)2.59642449
137extracellular fibril organization (GO:0043206)2.58975898
138sequestering of extracellular ligand from receptor (GO:0035581)2.58815012
139cochlea morphogenesis (GO:0090103)2.58671114
140extracellular matrix assembly (GO:0085029)2.58566388
141regulation of mitochondrial translation (GO:0070129)2.57591473
142organ formation (GO:0048645)2.57223032
143telomere maintenance via semi-conservative replication (GO:0032201)2.56699559
144regulation of cell fate specification (GO:0042659)2.56644455
145protein localization to cell surface (GO:0034394)2.55994653
146anterior/posterior axis specification, embryo (GO:0008595)2.54497445
147regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.53958569
148pattern specification involved in kidney development (GO:0061004)2.53253112
149anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.52694713
150regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.52534804
151endothelial cell proliferation (GO:0001935)2.52492373
152negative regulation of cartilage development (GO:0061037)2.51964017
153cardiac septum morphogenesis (GO:0060411)2.51375181
154translation (GO:0006412)2.49550444
155formation of translation preinitiation complex (GO:0001731)2.49421899
156protein complex disassembly (GO:0043241)2.47177586
157endothelial cell chemotaxis (GO:0035767)2.43122229
158* notochord development (GO:0030903)2.41989457
159DNA unwinding involved in DNA replication (GO:0006268)2.40139103
160ribonucleoprotein complex biogenesis (GO:0022613)2.39724587
161regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.38448162
162positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.34942339
163vasculature development (GO:0001944)2.31834517
164protein targeting to mitochondrion (GO:0006626)2.30910334
165regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.30357211
166transcription elongation from RNA polymerase III promoter (GO:0006385)2.29668502
167termination of RNA polymerase III transcription (GO:0006386)2.29668502
168macromolecular complex disassembly (GO:0032984)2.28879829
169DNA replication-independent nucleosome assembly (GO:0006336)2.28127764
170DNA replication-independent nucleosome organization (GO:0034724)2.28127764
171midgut development (GO:0007494)2.26711069
172protein targeting to membrane (GO:0006612)2.23382331

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.11025942
2TRIM28_21343339_ChIP-Seq_HEK293_Human6.39207150
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.45002557
4RARG_19884340_ChIP-ChIP_MEFs_Mouse4.41652659
5E2F7_22180533_ChIP-Seq_HELA_Human4.18911210
6CLOCK_20551151_ChIP-Seq_293T_Human3.78589068
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.56586532
8PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.23986094
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.97330315
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.95458824
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.69905385
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.65142695
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.62427369
14HIF1A_21447827_ChIP-Seq_MCF-7_Human2.60336103
15* NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.53708772
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.50230734
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.45100373
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.37761190
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.32230840
20* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.24367319
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.20207565
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.19137167
23KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.16541892
24KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.16541892
25KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.16541892
26GABP_17652178_ChIP-ChIP_JURKAT_Human2.15905998
27ESR1_21235772_ChIP-Seq_MCF-7_Human2.12714142
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.11571781
29ZNF263_19887448_ChIP-Seq_K562_Human2.11563026
30* CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.01680509
31EST1_17652178_ChIP-ChIP_JURKAT_Human2.00462440
32ETS1_20019798_ChIP-Seq_JURKAT_Human2.00221069
33* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.00108950
34THAP11_20581084_ChIP-Seq_MESCs_Mouse2.00000078
35CJUN_26792858_Chip-Seq_BT549_Human1.98103658
36* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.93988393
37* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.93438955
38DCP1A_22483619_ChIP-Seq_HELA_Human1.92437547
39* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.86475205
40FOXM1_23109430_ChIP-Seq_U2OS_Human1.83350727
41* TTF2_22483619_ChIP-Seq_HELA_Human1.83323819
42TP53_20018659_ChIP-ChIP_R1E_Mouse1.77778487
43WT1_19549856_ChIP-ChIP_CCG9911_Human1.77182062
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.75678356
45* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.75051979
46* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.72600324
47AR_21909140_ChIP-Seq_LNCAP_Human1.71579822
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.70953873
49* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.70840466
50* ELK3_25401928_ChIP-Seq_HUVEC_Human1.70715457
51ZFX_18555785_ChIP-Seq_MESCs_Mouse1.70698583
52NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.68823133
53NANOG_18555785_ChIP-Seq_MESCs_Mouse1.68252649
54* EED_16625203_ChIP-ChIP_MESCs_Mouse1.64947202
55POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.63962153
56* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.63573530
57* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.63162587
58NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.62765652
59TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59709817
60DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.59378320
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.59162641
62ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.59013712
63CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.58276885
64CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.57633114
65POU5F1_16153702_ChIP-ChIP_HESCs_Human1.56691453
66MYCN_18555785_ChIP-Seq_MESCs_Mouse1.56300327
67* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.56185243
68ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.55966050
69KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.53267645
70RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.51721679
71* BRD4_25478319_ChIP-Seq_HGPS_Human1.49863986
72DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.49593642
73E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.48598381
74POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.44233672
75ESR1_15608294_ChIP-ChIP_MCF-7_Human1.43661429
76* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.43447493
77SOX2_18555785_ChIP-Seq_MESCs_Mouse1.42989155
78ELK1_22589737_ChIP-Seq_MCF10A_Human1.42568368
79GABP_19822575_ChIP-Seq_HepG2_Human1.40391951
80* E2F1_21310950_ChIP-Seq_MCF-7_Human1.40303052
81PPAR_26484153_Chip-Seq_NCI-H1993_Human1.39790400
82TP63_19390658_ChIP-ChIP_HaCaT_Human1.39786886
83EP300_21415370_ChIP-Seq_HL-1_Mouse1.38642382
84TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.36612911
85* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.36509479
86* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.36509479
87SOX2_16153702_ChIP-ChIP_HESCs_Human1.36502609
88CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.36409192
89FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.35205532
90SOX2_20726797_ChIP-Seq_SW620_Human1.30856893
91ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.30851308
92FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.30133120
93RBPJ_22232070_ChIP-Seq_NCS_Mouse1.29835370
94SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.29743322
95NELFA_20434984_ChIP-Seq_ESCs_Mouse1.29254959
96* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.28836340
97* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.28773698
98HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.28696778
99* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.26852612
100WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.26523301
101YY1_21170310_ChIP-Seq_MESCs_Mouse1.25788478
102MYC_18555785_ChIP-Seq_MESCs_Mouse1.25156514
103SMAD_19615063_ChIP-ChIP_OVARY_Human1.24814475
104ELK1_19687146_ChIP-ChIP_HELA_Human1.24571905
105FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.23841101
106MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.23439561
107EGR1_19374776_ChIP-ChIP_THP-1_Human1.22326624
108CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.21016309
109PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.20971182
110TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20707152
111* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19263103
112NANOG_16153702_ChIP-ChIP_HESCs_Human1.18437436
113SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.18314990
114JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18104537
115YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15993217
116* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.15488029
117TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.15309651
118STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12963255
119EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.12857571
120* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.12622792
121HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.11897975
122UBF1/2_26484160_Chip-Seq_HMECs_Human1.10968216
123* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10118715
124FOXP3_21729870_ChIP-Seq_TREG_Human1.09001081
125KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08606991
126CDX2_20551321_ChIP-Seq_CACO-2_Human1.08405937
127MYC_19079543_ChIP-ChIP_MESCs_Mouse1.07024944
128EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.03992089
129NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.03762419
130* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.03669239
131* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03561712
132CTCF_18555785_ChIP-Seq_MESCs_Mouse1.01735629
133* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.01194463
134* XRN2_22483619_ChIP-Seq_HELA_Human1.00436371
135SA1_22415368_ChIP-Seq_MEFs_Mouse0.99124177
136TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.97999434
137* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97599003
138JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97150587
139* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.96342572
140SRF_21415370_ChIP-Seq_HL-1_Mouse0.95528578
141* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.95473884
142* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.95244733
143* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.94927845
144NANOG_21062744_ChIP-ChIP_HESCs_Human0.93669998
145* RACK7_27058665_Chip-Seq_MCF-7_Human0.93574465
146CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93439814
147* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.93178160
148NRF2_20460467_ChIP-Seq_MEFs_Mouse0.92784354
149NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.92784354
150* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.91722151
151SOX17_20123909_ChIP-Seq_XEN_Mouse0.91654684
152GATA2_21666600_ChIP-Seq_HMVEC_Human0.90601316
153* ATF3_27146783_Chip-Seq_COLON_Human0.89912253
154* TBX20_22328084_ChIP-Seq_HEART_Mouse0.87984003

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.75788765
2MP0005503_abnormal_tendon_morphology3.98954239
3MP0010368_abnormal_lymphatic_system3.85273740
4MP0001879_abnormal_lymphatic_vessel3.83090261
5MP0003279_aneurysm3.69980214
6MP0010030_abnormal_orbit_morphology3.58406862
7MP0004272_abnormal_basement_membrane3.25376306
8MP0003705_abnormal_hypodermis_morpholog3.07747191
9MP0005275_abnormal_skin_tensile2.87783473
10MP0001958_emphysema2.64239202
11MP0006054_spinal_hemorrhage2.61503480
12MP0009384_cardiac_valve_regurgitation2.60008695
13MP0009053_abnormal_anal_canal2.23146259
14MP0004957_abnormal_blastocyst_morpholog2.22338038
15MP0000767_abnormal_smooth_muscle2.10250068
16MP0003693_abnormal_embryo_hatching2.09584009
17MP0008932_abnormal_embryonic_tissue1.99950029
18MP0002295_abnormal_pulmonary_circulatio1.98258119
19MP0003111_abnormal_nucleus_morphology1.98251989
20MP0005508_abnormal_skeleton_morphology1.96446450
21MP0003077_abnormal_cell_cycle1.94705622
22MP0010094_abnormal_chromosome_stability1.91441529
23MP0002697_abnormal_eye_size1.87374551
24MP0000049_abnormal_middle_ear1.84363441
25MP0002282_abnormal_trachea_morphology1.83893821
26MP0002249_abnormal_larynx_morphology1.80811694
27MP0003385_abnormal_body_wall1.76049546
28MP0003941_abnormal_skin_development1.75714002
29MP0003942_abnormal_urinary_system1.74476659
30MP0000537_abnormal_urethra_morphology1.73134630
31MP0009250_abnormal_appendicular_skeleto1.71284059
32MP0005623_abnormal_meninges_morphology1.70622128
33MP0005023_abnormal_wound_healing1.63331236
34MP0005167_abnormal_blood-brain_barrier1.60168543
35MP0001542_abnormal_bone_strength1.56560296
36MP0005257_abnormal_intraocular_pressure1.55479650
37MP0001293_anophthalmia1.48547994
38MP0004883_abnormal_blood_vessel1.47892149
39MP0003136_yellow_coat_color1.46040914
40MP0001299_abnormal_eye_distance/1.45456727
41MP0002092_abnormal_eye_morphology1.41110366
42MP0008058_abnormal_DNA_repair1.40061165
43MP0003566_abnormal_cell_adhesion1.37340979
44MP0000516_abnormal_urinary_system1.34163674
45MP0005367_renal/urinary_system_phenotyp1.34163674
46MP0003828_pulmonary_edema1.33985813
47MP0002085_abnormal_embryonic_tissue1.33561774
48MP0002060_abnormal_skin_morphology1.32415189
49MP0005595_abnormal_vascular_smooth1.32352300
50MP0001730_embryonic_growth_arrest1.32202658
51MP0002932_abnormal_joint_morphology1.31647916
52MP0000566_synostosis1.31262219
53MP0002108_abnormal_muscle_morphology1.29399674
54MP0001849_ear_inflammation1.28547492
55MP0003115_abnormal_respiratory_system1.27530712
56MP0009379_abnormal_foot_pigmentation1.26769662
57MP0000534_abnormal_ureter_morphology1.26306902
58MP0002127_abnormal_cardiovascular_syste1.26172140
59MP0000579_abnormal_nail_morphology1.24647594
60MP0006292_abnormal_olfactory_placode1.24616449
61MP0000350_abnormal_cell_proliferation1.22950806
62MP0001286_abnormal_eye_development1.21589039
63MP0002084_abnormal_developmental_patter1.20951734
64MP0003724_increased_susceptibility_to1.18260498
65MP0001672_abnormal_embryogenesis/_devel1.18242504
66MP0005380_embryogenesis_phenotype1.18242504
67MP0000163_abnormal_cartilage_morphology1.15610634
68MP0009672_abnormal_birth_weight1.15265098
69MP0003984_embryonic_growth_retardation1.15016906
70MP0002128_abnormal_blood_circulation1.12665836
71MP0005171_absent_coat_pigmentation1.12121851
72MP0005164_abnormal_response_to1.11187046
73MP0002088_abnormal_embryonic_growth/wei1.10268665
74MP0000750_abnormal_muscle_regeneration1.09479200
75MP0000428_abnormal_craniofacial_morphol1.09091009
76MP0006138_congestive_heart_failure1.06962498
77MP0003755_abnormal_palate_morphology1.04248518
78MP0001614_abnormal_blood_vessel1.03942216
79MP0002938_white_spotting1.02898414
80MP0000762_abnormal_tongue_morphology1.02698952
81MP0001697_abnormal_embryo_size1.02655305
82MP0002009_preneoplasia1.01202042
83MP0005501_abnormal_skin_physiology1.00799035
84MP0000733_abnormal_muscle_development0.99162505
85MP0005197_abnormal_uvea_morphology0.97132192
86MP0005390_skeleton_phenotype0.97082869
87MP0002080_prenatal_lethality0.96984759
88MP0000249_abnormal_blood_vessel0.96984619
89MP0002877_abnormal_melanocyte_morpholog0.95334184
90MP0002925_abnormal_cardiovascular_devel0.95157554
91MP0003283_abnormal_digestive_organ0.93974072
92MP0003091_abnormal_cell_migration0.93612778
93MP0003937_abnormal_limbs/digits/tail_de0.93593284
94MP0001915_intracranial_hemorrhage0.92953910
95MP0003186_abnormal_redox_activity0.92622810
96MP0002115_abnormal_skeleton_extremities0.92309259
97MP0003011_delayed_dark_adaptation0.92210248
98MP0000462_abnormal_digestive_system0.91758510
99MP0001175_abnormal_lung_morphology0.91214482
100MP0003935_abnormal_craniofacial_develop0.91208730
101MP0001243_abnormal_dermal_layer0.90366093
102MP0000013_abnormal_adipose_tissue0.88309050
103MP0008007_abnormal_cellular_replicative0.88025850
104MP0005193_abnormal_anterior_eye0.86313395
105MP0005084_abnormal_gallbladder_morpholo0.83465997
106MP0005165_increased_susceptibility_to0.83301555
107MP0002086_abnormal_extraembryonic_tissu0.83064859
108MP0002233_abnormal_nose_morphology0.82136346
109MP0003567_abnormal_fetal_cardiomyocyte0.81597640
110MP0000432_abnormal_head_morphology0.79726382
111MP0009697_abnormal_copulation0.79070023
112MP0010352_gastrointestinal_tract_polyps0.78691295
113MP0001661_extended_life_span0.78028895
114MP0002113_abnormal_skeleton_development0.76738498
115MP0005670_abnormal_white_adipose0.76398399
116MP0004133_heterotaxia0.75848517
117MP0005076_abnormal_cell_differentiation0.75093763
118MP0001544_abnormal_cardiovascular_syste0.75092395
119MP0005385_cardiovascular_system_phenoty0.75092395
120MP0000343_altered_response_to0.74904804
121MP0000751_myopathy0.74489317
122MP0003950_abnormal_plasma_membrane0.74481863
123MP0002109_abnormal_limb_morphology0.73735169
124MP0003938_abnormal_ear_development0.72944471
125MP0005248_abnormal_Harderian_gland0.72139347
126MP0002111_abnormal_tail_morphology0.71469532
127MP0002116_abnormal_craniofacial_bone0.71061507
128MP0002254_reproductive_system_inflammat0.70521465
129MP0002089_abnormal_postnatal_growth/wei0.69804306
130MP0002896_abnormal_bone_mineralization0.68288547
131MP0000266_abnormal_heart_morphology0.67321041
132MP0000858_altered_metastatic_potential0.67219648
133MP0003122_maternal_imprinting0.66780247
134MP0010630_abnormal_cardiac_muscle0.66226519
135MP0002132_abnormal_respiratory_system0.64632170
136MP0002133_abnormal_respiratory_system0.64432884
137MP0005388_respiratory_system_phenotype0.64432884
138MP0003448_altered_tumor_morphology0.64130398
139MP0003119_abnormal_digestive_system0.63320427
140MP0003315_abnormal_perineum_morphology0.63145474

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.78008225
2Premature rupture of membranes (HP:0001788)5.63303504
3Aortic aneurysm (HP:0004942)4.63714811
4Vascular tortuosity (HP:0004948)3.83458670
5Aortic dissection (HP:0002647)3.79600587
6Shallow orbits (HP:0000586)3.59436402
7Short hallux (HP:0010109)3.58492419
8Broad metatarsal (HP:0001783)3.53920204
9Soft skin (HP:0000977)3.48705228
10Mesangial abnormality (HP:0001966)3.45573088
11Pulmonary artery stenosis (HP:0004415)3.37069491
12Partial duplication of thumb phalanx (HP:0009944)3.36928893
13Aplasia/Hypoplasia of the hallux (HP:0008362)3.26757346
14Bladder diverticulum (HP:0000015)3.22836902
15Biconcave vertebral bodies (HP:0004586)3.17487135
16Abnormality of dentin (HP:0010299)2.95239519
17Dilatation of the ascending aorta (HP:0005111)2.93620471
18Ulnar bowing (HP:0003031)2.86541664
19Reticulocytopenia (HP:0001896)2.83988598
20Ankle contracture (HP:0006466)2.80409109
21Neonatal short-limb short stature (HP:0008921)2.74251486
22Spinal rigidity (HP:0003306)2.72712982
23Overriding aorta (HP:0002623)2.71960844
24Wormian bones (HP:0002645)2.65273078
25Vertebral compression fractures (HP:0002953)2.64115956
26Abnormality of cells of the erythroid lineage (HP:0012130)2.63133583
27Short middle phalanx of the 5th finger (HP:0004220)2.60561494
28Cerebral aneurysm (HP:0004944)2.60012271
29Follicular hyperkeratosis (HP:0007502)2.57126025
30Aplasia involving bones of the upper limbs (HP:0009823)2.53794082
31Aplasia of the phalanges of the hand (HP:0009802)2.53794082
32Aplasia involving bones of the extremities (HP:0009825)2.53794082
33Blue sclerae (HP:0000592)2.52549311
34Hypoplastic left heart (HP:0004383)2.51488142
35Atrophic scars (HP:0001075)2.50888387
36Abnormal number of erythroid precursors (HP:0012131)2.49230498
37Broad toe (HP:0001837)2.48509720
38Aortic valve stenosis (HP:0001650)2.38605461
39Alopecia of scalp (HP:0002293)2.38277497
40Duplication of thumb phalanx (HP:0009942)2.33297851
41Absent toe (HP:0010760)2.29209644
42Camptodactyly of toe (HP:0001836)2.29071798
43Fragile skin (HP:0001030)2.24438150
44Nonimmune hydrops fetalis (HP:0001790)2.24398455
45Abnormal umbilical cord blood vessels (HP:0011403)2.21088119
46Single umbilical artery (HP:0001195)2.21088119
47Abnormality of the fetal cardiovascular system (HP:0010948)2.21088119
48Selective tooth agenesis (HP:0001592)2.20523042
49Wrist flexion contracture (HP:0001239)2.20471861
50Tarsal synostosis (HP:0008368)2.20366475
51Abnormality of the umbilical cord (HP:0010881)2.18801020
52Cervical subluxation (HP:0003308)2.15994291
53Abnormal number of incisors (HP:0011064)2.15667952
54Mitral regurgitation (HP:0001653)2.15141684
55Preaxial foot polydactyly (HP:0001841)2.14964120
56Turricephaly (HP:0000262)2.13674539
57Arterial tortuosity (HP:0005116)2.12797376
58Broad hallux (HP:0010055)2.12742846
59Microvesicular hepatic steatosis (HP:0001414)2.11235218
60Increased connective tissue (HP:0009025)2.10973251
61Coronal craniosynostosis (HP:0004440)2.10621674
62Abnormality of the middle phalanges of the toes (HP:0010183)2.10496149
63Peritonitis (HP:0002586)2.10210184
64Septo-optic dysplasia (HP:0100842)2.09822475
65Redundant skin (HP:0001582)2.09643512
66Premature skin wrinkling (HP:0100678)2.08429958
67Aplasia/Hypoplasia of the sacrum (HP:0008517)2.08390992
68Wide anterior fontanel (HP:0000260)2.08258386
69Congenital, generalized hypertrichosis (HP:0004540)2.05285076
70Macrocytic anemia (HP:0001972)2.04939619
71Renal duplication (HP:0000075)2.01040115
72Short 4th metacarpal (HP:0010044)2.00354372
73Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.00354372
74Synostosis involving bones of the feet (HP:0009140)2.00114845
75Synostosis involving bones of the lower limbs (HP:0009138)2.00114845
76Hypoplastic pelvis (HP:0008839)1.96392786
77Abnormal delivery (HP:0001787)1.94701643
78Bowel diverticulosis (HP:0005222)1.94550559
79Acute necrotizing encephalopathy (HP:0006965)1.94006325
80Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.93050866
81Thin ribs (HP:0000883)1.92742420
82Abnormalities of placenta or umbilical cord (HP:0001194)1.92638665
83Trismus (HP:0000211)1.91872676
84Hyperacusis (HP:0010780)1.91731287
85Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.91421921
86Abnormal mitochondria in muscle tissue (HP:0008316)1.91414776
87Deviation of the hallux (HP:0010051)1.91022821
88Overgrowth (HP:0001548)1.90805260
89Abnormality of the distal phalanges of the toes (HP:0010182)1.90349719
90Short nail (HP:0001799)1.89694289
91Partial duplication of the phalanx of hand (HP:0009999)1.88277476
92Hematochezia (HP:0002573)1.88201159
93Abnormality of the 4th metacarpal (HP:0010012)1.87431825
94Mesomelia (HP:0003027)1.86191723
95Mitral valve prolapse (HP:0001634)1.84752061
96Joint contractures involving the joints of the feet (HP:0100492)1.84477577
97Flexion contracture of toe (HP:0005830)1.84477577
98Hypoplastic heart (HP:0001961)1.84093004
99Calcaneovalgus deformity (HP:0001848)1.84021120
100Osteolytic defects of the hand bones (HP:0009699)1.83778364
101Osteolytic defects of the phalanges of the hand (HP:0009771)1.83778364
102Elbow flexion contracture (HP:0002987)1.83268532
103Rough bone trabeculation (HP:0100670)1.83042052
104Chondrocalcinosis (HP:0000934)1.82033464
105Spastic diplegia (HP:0001264)1.81612374
106Aneurysm (HP:0002617)1.80909952
107Hypoplasia of the capital femoral epiphysis (HP:0003090)1.80035198
108Abnormality of secondary sexual hair (HP:0009888)1.78903871
109Abnormality of the axillary hair (HP:0100134)1.78903871
110Delayed cranial suture closure (HP:0000270)1.78062886
111Absent eyelashes (HP:0000561)1.77384379
112Pterygium (HP:0001059)1.75950266
113Vertebral hypoplasia (HP:0008417)1.74606868
114Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.74606868
115Hydroureter (HP:0000072)1.74255994
116Carpal synostosis (HP:0009702)1.73424537
117Patent foramen ovale (HP:0001655)1.73406214
118Deformed tarsal bones (HP:0008119)1.73287471
119Hallux valgus (HP:0001822)1.71579841
120Abnormality of the phalanges of the 5th finger (HP:0004213)1.71263034
121Natal tooth (HP:0000695)1.70745739
122Abnormality of Sharpey fibers (HP:0100685)1.69590766
123Shoulder girdle muscle weakness (HP:0003547)1.69559956
124Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.69396419
125Short 5th finger (HP:0009237)1.69214955
126Acute encephalopathy (HP:0006846)1.69003064
127Short clavicles (HP:0000894)1.68481820
128Abnormality of the parietal bone (HP:0002696)1.67291909
129Vertebral clefting (HP:0008428)1.66758476
130Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.65889770
131Absent epiphyses (HP:0010577)1.65889770
132Spinal cord lesions (HP:0100561)1.65695720
133Syringomyelia (HP:0003396)1.65695720
134Concave nail (HP:0001598)1.65637824
135Hepatocellular necrosis (HP:0001404)1.64989553
136Anophthalmia (HP:0000528)1.64945851
137Entropion (HP:0000621)1.64617710
138Morphological abnormality of the middle ear (HP:0008609)1.64194705
139Hyperextensible skin (HP:0000974)1.63866863
140Stenosis of the external auditory canal (HP:0000402)1.63675010
141Broad distal phalanx of finger (HP:0009836)1.63451359
142Nasolacrimal duct obstruction (HP:0000579)1.63182006
143Broad long bones (HP:0005622)1.62329873
144Aplasia of the musculature (HP:0100854)1.61254556
145Bronchomalacia (HP:0002780)1.61144907
146Absent septum pellucidum (HP:0001331)1.61023911
147Joint laxity (HP:0001388)1.60516850
148Maternal diabetes (HP:0009800)1.60425553
149Small epiphyses (HP:0010585)1.59732605
150Genu recurvatum (HP:0002816)1.59271330
151Testicular atrophy (HP:0000029)1.59024990
152Arnold-Chiari malformation (HP:0002308)1.57433114
153Elfin facies (HP:0004428)1.56984732
154Mitochondrial inheritance (HP:0001427)1.56883604
155Insomnia (HP:0100785)1.55306174
156Abnormal lung lobation (HP:0002101)1.54660165
157Abnormality of the 2nd finger (HP:0004100)1.53845515

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR4.36442741
2TIE13.86946500
3VRK23.51309947
4EPHB23.47168804
5MYLK2.65399873
6BUB12.64684337
7STK38L2.57536492
8LATS22.53901347
9VRK12.28291702
10ERN12.26620631
11CDC72.22706767
12EPHA32.16316150
13TGFBR12.05669005
14TRIB31.99489970
15DDR21.96261071
16SMG11.90472291
17TTK1.88562931
18TGFBR21.88079085
19TESK11.86781333
20TESK21.86552310
21SRPK11.86452115
22PDGFRA1.84518204
23NME21.76093712
24LATS11.75716549
25ZAK1.67317472
26PIM21.66249913
27STK161.65871209
28TTN1.62339215
29RPS6KA41.57299416
30NUAK11.55085893
31LIMK11.51587989
32AKT31.50794314
33PAK21.46356902
34MAP3K31.43300817
35WEE11.36970863
36NEK11.35680898
37LRRK21.32820138
38ERBB41.30727008
39PAK41.30552371
40MST1R1.30392461
41ILK1.26938210
42TAF11.24235755
43FER1.20464633
44PBK1.20181729
45MAPK151.18647935
46STK101.08620382
47PTK61.08409973
48PDK21.07941810
49MAP2K21.05670162
50ROCK11.03130197
51PTK2B1.03113825
52MKNK11.01742202
53MKNK21.01458281
54LMTK21.00949616
55NME10.98052518
56PNCK0.95824053
57ARAF0.93965710
58MELK0.92827152
59ERBB30.92275151
60NLK0.91156415
61DYRK30.89052210
62BRSK10.88738758
63FRK0.88324195
64STK40.87840102
65CDK80.86573247
66FGFR10.86007981
67STK30.83363314
68MST40.83229876
69PAK30.82478462
70PTK20.80508927
71MAP3K110.79319947
72NTRK10.78473006
73CHEK20.78334905
74PLK40.75685888
75ABL20.74709003
76TLK10.71902904
77GRK10.71157421
78MAP2K10.70761021
79NEK90.70401191
80STK240.69709911
81AURKB0.69007383
82TAOK20.68766641
83MET0.68697155
84RPS6KA50.66045198
85CDK70.64668542
86FGFR40.63892609
87PIK3CA0.63857770
88PAK10.60813469
89CSNK1G10.60557393
90PASK0.58572459
91RPS6KB20.58515022
92MAP3K120.57384653
93MAP3K80.57243016
94FGFR20.57174413
95EIF2AK20.56341449
96MOS0.56235394
97CDK90.56167150
98DAPK30.56100572
99ATR0.55442328
100PIK3CG0.51757257
101BCR0.51467551
102AKT20.51110533
103INSR0.51049593
104BCKDK0.50867537
105RIPK10.50151170
106MAPK70.49649081
107ROCK20.49620478
108PLK30.49617338
109DYRK1B0.48710324
110ERBB20.46622503
111TRPM70.45224745
112ICK0.45196372
113CHEK10.45123284
114PLK10.44682872
115EIF2AK10.44400866
116CDC42BPA0.44190490
117MTOR0.43404653
118DMPK0.43032303
119CHUK0.42498093
120SIK10.42472409
121PRKD10.41987132
122AURKA0.41790874
123BRSK20.41535152
124CSNK1G30.41285081
125BRAF0.40386611
126FLT30.39626815
127IGF1R0.38868803
128NEK20.38770661
129PRKG20.38446539
130CDK60.38238305
131NEK60.38159508
132DYRK20.36914979
133BMX0.36644362
134CAMK2G0.36494569
135TSSK60.36192464
136FGFR30.36064387
137CDK40.35692200
138MAPKAPK50.35229750
139EPHA20.35202880
140MAP3K100.34894669

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052172.97102588
2ECM-receptor interaction_Homo sapiens_hsa045122.83767058
3* TGF-beta signaling pathway_Homo sapiens_hsa043502.71041177
4Hippo signaling pathway_Homo sapiens_hsa043902.56316811
5Ribosome_Homo sapiens_hsa030102.51892102
6Adherens junction_Homo sapiens_hsa045202.37547540
7Focal adhesion_Homo sapiens_hsa045102.32158314
8Proteasome_Homo sapiens_hsa030502.29318985
9Parkinsons disease_Homo sapiens_hsa050122.24057180
10Sulfur relay system_Homo sapiens_hsa041222.15453642
11Oxidative phosphorylation_Homo sapiens_hsa001902.13763853
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.97156846
13Malaria_Homo sapiens_hsa051441.95031402
14Hedgehog signaling pathway_Homo sapiens_hsa043401.94298488
15Proteoglycans in cancer_Homo sapiens_hsa052051.87238964
16AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.78670095
17Huntingtons disease_Homo sapiens_hsa050161.77616064
18Bladder cancer_Homo sapiens_hsa052191.68311389
19* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.68173258
20Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.64216893
21Folate biosynthesis_Homo sapiens_hsa007901.62935383
22Small cell lung cancer_Homo sapiens_hsa052221.62100107
23Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.59797474
24Notch signaling pathway_Homo sapiens_hsa043301.57378001
25Systemic lupus erythematosus_Homo sapiens_hsa053221.54327217
26Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.53693534
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.52280964
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.51874974
29Leukocyte transendothelial migration_Homo sapiens_hsa046701.49847207
30p53 signaling pathway_Homo sapiens_hsa041151.47406327
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.42723393
32Protein digestion and absorption_Homo sapiens_hsa049741.41602724
33Alzheimers disease_Homo sapiens_hsa050101.41580845
34PI3K-Akt signaling pathway_Homo sapiens_hsa041511.39397589
35Tight junction_Homo sapiens_hsa045301.39266212
36MicroRNAs in cancer_Homo sapiens_hsa052061.37712430
37Dilated cardiomyopathy_Homo sapiens_hsa054141.37461098
38RNA polymerase_Homo sapiens_hsa030201.37120001
39Pyruvate metabolism_Homo sapiens_hsa006201.35801243
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.32530147
41HTLV-I infection_Homo sapiens_hsa051661.32023728
42Spliceosome_Homo sapiens_hsa030401.29143080
43Cell cycle_Homo sapiens_hsa041101.28494489
44Viral myocarditis_Homo sapiens_hsa054161.26955566
45Pathways in cancer_Homo sapiens_hsa052001.26814771
46Non-homologous end-joining_Homo sapiens_hsa034501.26808889
47Glutathione metabolism_Homo sapiens_hsa004801.25904808
48Complement and coagulation cascades_Homo sapiens_hsa046101.24824816
49Vitamin B6 metabolism_Homo sapiens_hsa007501.22460511
50Alcoholism_Homo sapiens_hsa050341.15829308
51Prostate cancer_Homo sapiens_hsa052151.10787458
52Rap1 signaling pathway_Homo sapiens_hsa040151.09436233
53Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.03713478
54Pentose phosphate pathway_Homo sapiens_hsa000301.03328023
55Fatty acid degradation_Homo sapiens_hsa000711.00816419
56Arginine and proline metabolism_Homo sapiens_hsa003300.98482660
57Melanoma_Homo sapiens_hsa052180.98458330
58PPAR signaling pathway_Homo sapiens_hsa033200.97775797
59RNA degradation_Homo sapiens_hsa030180.97757182
60Regulation of actin cytoskeleton_Homo sapiens_hsa048100.96778987
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.96373444
62Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.95450000
63Steroid biosynthesis_Homo sapiens_hsa001000.95402867
64Amoebiasis_Homo sapiens_hsa051460.94911955
65Fatty acid elongation_Homo sapiens_hsa000620.94890367
66Fanconi anemia pathway_Homo sapiens_hsa034600.91215476
67HIF-1 signaling pathway_Homo sapiens_hsa040660.90035384
68Prion diseases_Homo sapiens_hsa050200.89198973
69Central carbon metabolism in cancer_Homo sapiens_hsa052300.89086536
70Chemical carcinogenesis_Homo sapiens_hsa052040.88407745
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88172407
72Wnt signaling pathway_Homo sapiens_hsa043100.87960237
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87937398
74Selenocompound metabolism_Homo sapiens_hsa004500.87835372
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.87602776
76Arachidonic acid metabolism_Homo sapiens_hsa005900.86748135
77N-Glycan biosynthesis_Homo sapiens_hsa005100.85813908
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85437172
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.85421856
80mRNA surveillance pathway_Homo sapiens_hsa030150.82892897
81DNA replication_Homo sapiens_hsa030300.81877479
82Cardiac muscle contraction_Homo sapiens_hsa042600.81145040
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79230119
84Melanogenesis_Homo sapiens_hsa049160.78448586
85Pyrimidine metabolism_Homo sapiens_hsa002400.77929853
86Nitrogen metabolism_Homo sapiens_hsa009100.76912961
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76428418
88Base excision repair_Homo sapiens_hsa034100.75310474
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.75190912
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.75176464
91Vitamin digestion and absorption_Homo sapiens_hsa049770.74773091
92RNA transport_Homo sapiens_hsa030130.74202428
93Fructose and mannose metabolism_Homo sapiens_hsa000510.72125166
94Protein export_Homo sapiens_hsa030600.71930204
95One carbon pool by folate_Homo sapiens_hsa006700.69580204
96Thyroid cancer_Homo sapiens_hsa052160.69231539
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69229350
98Mismatch repair_Homo sapiens_hsa034300.69216421
99TNF signaling pathway_Homo sapiens_hsa046680.69066767
100Retinol metabolism_Homo sapiens_hsa008300.64090581
101Shigellosis_Homo sapiens_hsa051310.62341120
102Basal transcription factors_Homo sapiens_hsa030220.60338276
103Apoptosis_Homo sapiens_hsa042100.57577364
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51487567
105Vascular smooth muscle contraction_Homo sapiens_hsa042700.50546006
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49985503
107Fatty acid metabolism_Homo sapiens_hsa012120.48894042
108Chronic myeloid leukemia_Homo sapiens_hsa052200.48412024
109Galactose metabolism_Homo sapiens_hsa000520.47993244
110Axon guidance_Homo sapiens_hsa043600.46978408
111Nucleotide excision repair_Homo sapiens_hsa034200.46574675
112Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46271223
113Bile secretion_Homo sapiens_hsa049760.45579328
114Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.45328483
115Viral carcinogenesis_Homo sapiens_hsa052030.44534863
116Drug metabolism - other enzymes_Homo sapiens_hsa009830.43128874
117Epstein-Barr virus infection_Homo sapiens_hsa051690.43045949
118Legionellosis_Homo sapiens_hsa051340.42755660
119Metabolic pathways_Homo sapiens_hsa011000.42204757
120Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.41102347
121Purine metabolism_Homo sapiens_hsa002300.40187200
122Sulfur metabolism_Homo sapiens_hsa009200.39690462
123Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.39548228
124Mineral absorption_Homo sapiens_hsa049780.38668675
125Homologous recombination_Homo sapiens_hsa034400.38464740
126Toxoplasmosis_Homo sapiens_hsa051450.38185370
127Carbon metabolism_Homo sapiens_hsa012000.37211423
128Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34962372
129Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.33674590
130Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33548383
131Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.33287395
132Vibrio cholerae infection_Homo sapiens_hsa051100.32998721
133Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32881652
134Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.32583654
135Lysine degradation_Homo sapiens_hsa003100.31737307
136Arginine biosynthesis_Homo sapiens_hsa002200.30990921
137Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30976399
138Biosynthesis of amino acids_Homo sapiens_hsa012300.30548460
139NF-kappa B signaling pathway_Homo sapiens_hsa040640.30236939
140Ras signaling pathway_Homo sapiens_hsa040140.27843633

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