IDE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosome assembly (GO:0042255)4.77547053
2establishment of skin barrier (GO:0061436)4.29342995
3nuclear pore complex assembly (GO:0051292)4.21466567
4nuclear pore organization (GO:0006999)4.16058578
5keratinization (GO:0031424)4.07542420
6glycine metabolic process (GO:0006544)4.04727014
7folic acid-containing compound biosynthetic process (GO:0009396)4.04061936
8bundle of His cell to Purkinje myocyte communication (GO:0086069)3.93071824
9mitotic metaphase plate congression (GO:0007080)3.92545081
10regulation of water loss via skin (GO:0033561)3.89694024
11serine family amino acid biosynthetic process (GO:0009070)3.85868402
12DNA unwinding involved in DNA replication (GO:0006268)3.77704416
13lysine metabolic process (GO:0006553)3.75729275
14lysine catabolic process (GO:0006554)3.75729275
15desmosome organization (GO:0002934)3.61180961
16L-serine metabolic process (GO:0006563)3.60889731
17alpha-linolenic acid metabolic process (GO:0036109)3.57461301
18tRNA aminoacylation for protein translation (GO:0006418)3.57410143
19tRNA aminoacylation (GO:0043039)3.50279726
20amino acid activation (GO:0043038)3.50279726
21metaphase plate congression (GO:0051310)3.47669673
22cysteine metabolic process (GO:0006534)3.43731297
23regulation of translational fidelity (GO:0006450)3.42609535
24negative regulation of DNA repair (GO:0045738)3.42130395
25regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.42046481
26serine family amino acid metabolic process (GO:0009069)3.38565522
27DNA replication checkpoint (GO:0000076)3.38054527
28amino-acid betaine metabolic process (GO:0006577)3.37470333
29IMP biosynthetic process (GO:0006188)3.37033713
30mitotic chromosome condensation (GO:0007076)3.35979675
31regulation of centriole replication (GO:0046599)3.31045623
32valine metabolic process (GO:0006573)3.30960290
33mitotic sister chromatid cohesion (GO:0007064)3.30310340
34IMP metabolic process (GO:0046040)3.28531114
35COPI coating of Golgi vesicle (GO:0048205)3.21094661
36Golgi transport vesicle coating (GO:0048200)3.21094661
37mitotic nuclear envelope disassembly (GO:0007077)3.16134100
38tetrahydrofolate metabolic process (GO:0046653)3.15202502
39protein localization to kinetochore (GO:0034501)3.14609876
40positive regulation of chromosome segregation (GO:0051984)3.10896306
41sulfur amino acid catabolic process (GO:0000098)3.10683415
42positive regulation of mitotic sister chromatid separation (GO:1901970)3.10137336
43positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.10137336
44positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.10137336
45keratinocyte differentiation (GO:0030216)3.09278244
46urea cycle (GO:0000050)3.08599257
47urea metabolic process (GO:0019627)3.08599257
48serine family amino acid catabolic process (GO:0009071)3.07346128
49double-strand break repair via nonhomologous end joining (GO:0006303)3.07034542
50non-recombinational repair (GO:0000726)3.07034542
51response to X-ray (GO:0010165)3.06107055
522-oxoglutarate metabolic process (GO:0006103)3.05201779
53membrane disassembly (GO:0030397)3.05155251
54nuclear envelope disassembly (GO:0051081)3.05155251
55negative regulation of fatty acid biosynthetic process (GO:0045717)3.04409659
56pore complex assembly (GO:0046931)3.03542987
57folic acid metabolic process (GO:0046655)3.02568425
58fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.02106789
59L-phenylalanine metabolic process (GO:0006558)3.01457546
60erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.01457546
61carnitine metabolic process (GO:0009437)3.01411986
62erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.00594037
63L-phenylalanine catabolic process (GO:0006559)3.00594037
64cellular protein complex localization (GO:0034629)2.99999014
65negative regulation of digestive system process (GO:0060457)2.99979473
66cellular hyperosmotic response (GO:0071474)2.97039323
67one-carbon metabolic process (GO:0006730)2.95856955
68regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.95814286
69ethanol oxidation (GO:0006069)2.95340544
70homocysteine metabolic process (GO:0050667)2.94332200
71glyoxylate metabolic process (GO:0046487)2.94152737
72kynurenine metabolic process (GO:0070189)2.94136758
73mitochondrial RNA metabolic process (GO:0000959)2.93381609
74nucleobase biosynthetic process (GO:0046112)2.93025908
75aspartate family amino acid catabolic process (GO:0009068)2.91914115
76establishment of chromosome localization (GO:0051303)2.91479954
77linoleic acid metabolic process (GO:0043651)2.91051226
78gap junction assembly (GO:0016264)2.90389962
79sister chromatid segregation (GO:0000819)2.89227213
80mitotic sister chromatid segregation (GO:0000070)2.88729341
81CENP-A containing nucleosome assembly (GO:0034080)2.88167846
82keratinocyte proliferation (GO:0043616)2.81930045
83fatty acid transmembrane transport (GO:1902001)2.81373598
84DNA duplex unwinding (GO:0032508)2.80258261
85carnitine shuttle (GO:0006853)2.80012804
86regulation of translational termination (GO:0006449)2.80004538
87drinking behavior (GO:0042756)2.77586055
88DNA strand elongation involved in DNA replication (GO:0006271)2.77412020
89imidazole-containing compound metabolic process (GO:0052803)2.76884540
90DNA geometric change (GO:0032392)2.76748440
91chaperone-mediated protein complex assembly (GO:0051131)2.76381175
92regulation of cholesterol homeostasis (GO:2000188)2.75949512
93regulation of histone H3-K9 methylation (GO:0051570)2.74324182
94nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.72778691
95pentose-phosphate shunt (GO:0006098)2.72309968
96DNA replication-dependent nucleosome assembly (GO:0006335)2.71864434
97DNA replication-dependent nucleosome organization (GO:0034723)2.71864434
98chromatin remodeling at centromere (GO:0031055)2.71322023
99hemidesmosome assembly (GO:0031581)2.70332439
100tricarboxylic acid cycle (GO:0006099)2.70149479
101regulation of mitotic metaphase/anaphase transition (GO:0030071)2.69485733
102regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.69485733
103hair cycle (GO:0042633)2.68152661
104molting cycle (GO:0042303)2.68152661
105protein localization to chromosome, centromeric region (GO:0071459)2.67811236
106nitrogen cycle metabolic process (GO:0071941)2.66952880
107regulation of chromosome segregation (GO:0051983)2.65653323
108regulation of triglyceride catabolic process (GO:0010896)2.64909030
109negative regulation of fibrinolysis (GO:0051918)2.64826601
110regulation of protein activation cascade (GO:2000257)2.64230316
111regulation of hippo signaling (GO:0035330)2.63822878
112cellular modified amino acid catabolic process (GO:0042219)2.63138969
113bile acid biosynthetic process (GO:0006699)2.62524416
114aromatic amino acid family catabolic process (GO:0009074)2.62166511
115replicative senescence (GO:0090399)2.61971757
116triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.61937140
117spindle checkpoint (GO:0031577)2.61590113
118ribosome biogenesis (GO:0042254)2.61557747
119DNA strand elongation (GO:0022616)2.61151958
120folic acid-containing compound metabolic process (GO:0006760)2.59868890
121formation of translation preinitiation complex (GO:0001731)2.59480102
122translesion synthesis (GO:0019985)2.57357123
123carnitine transmembrane transport (GO:1902603)2.57111001
124pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.56381573
125UMP biosynthetic process (GO:0006222)2.56381573
126pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.56381573
127UMP metabolic process (GO:0046049)2.56381573
128viral mRNA export from host cell nucleus (GO:0046784)2.55736478
129dicarboxylic acid biosynthetic process (GO:0043650)2.55308258
130DNA replication initiation (GO:0006270)2.55235112
131RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.54868566
132regulation of sister chromatid segregation (GO:0033045)2.54661110
133regulation of mitotic sister chromatid separation (GO:0010965)2.54661110
134regulation of mitotic sister chromatid segregation (GO:0033047)2.54661110
135complement activation, alternative pathway (GO:0006957)2.54591436
136nuclear envelope organization (GO:0006998)2.54141494
137mitotic spindle checkpoint (GO:0071174)2.54099782
138phospholipid efflux (GO:0033700)2.53992185
139negative regulation of chromosome segregation (GO:0051985)2.53895536
140regulation of centrosome cycle (GO:0046605)2.52397266
141positive regulation of actin filament depolymerization (GO:0030836)2.52292427
142DNA ligation (GO:0006266)2.52130902
143regulation of complement activation (GO:0030449)2.51890073
144protein complex localization (GO:0031503)2.51880104
145amino-acid betaine transport (GO:0015838)2.49900232
146carnitine transport (GO:0015879)2.49900232
147purine nucleobase biosynthetic process (GO:0009113)2.49756767
148tricarboxylic acid metabolic process (GO:0072350)2.49019935
149negative regulation of mitotic sister chromatid segregation (GO:0033048)2.48552020
150negative regulation of mitotic sister chromatid separation (GO:2000816)2.48552020
151negative regulation of sister chromatid segregation (GO:0033046)2.48552020
152negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.48552020
153negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.48552020
154regulation of RNA export from nucleus (GO:0046831)2.48516533
155alpha-amino acid catabolic process (GO:1901606)2.48344253
156fatty acid homeostasis (GO:0055089)2.47837042
157mitotic G1 DNA damage checkpoint (GO:0031571)2.47836232
158fatty acid beta-oxidation (GO:0006635)2.47492555
159NADPH regeneration (GO:0006740)2.47252151
160sister chromatid cohesion (GO:0007062)2.47099036
161acetyl-CoA metabolic process (GO:0006084)2.46027694
162COPII vesicle coating (GO:0048208)2.45416595
163epidermal cell differentiation (GO:0009913)2.45261537
164regulation of translational elongation (GO:0006448)2.45260882
165AMP metabolic process (GO:0046033)2.44052052
166quaternary ammonium group transport (GO:0015697)2.42184628
167meiotic chromosome segregation (GO:0045132)2.39746951
168telomere maintenance via semi-conservative replication (GO:0032201)2.38929661
169regulation of sister chromatid cohesion (GO:0007063)2.38238001

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.51564634
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.41828070
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.81291568
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.47639983
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.09077696
6PPARA_22158963_ChIP-Seq_LIVER_Mouse2.96021072
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.93744719
8RXR_22158963_ChIP-Seq_LIVER_Mouse2.85525427
9* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.75155505
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.63425704
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.37013582
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.31899911
13AR_21909140_ChIP-Seq_LNCAP_Human2.23485916
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.19316796
15ZNF263_19887448_ChIP-Seq_K562_Human2.18590254
16LXR_22158963_ChIP-Seq_LIVER_Mouse2.15051190
17SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.12505959
18EGR1_23403033_ChIP-Seq_LIVER_Mouse2.10095583
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.08728747
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.06376349
21* PADI4_21655091_ChIP-ChIP_MCF-7_Human2.06323006
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.02455470
23RBPJ_22232070_ChIP-Seq_NCS_Mouse1.90382693
24ELK1_19687146_ChIP-ChIP_HELA_Human1.88778519
25MYC_22102868_ChIP-Seq_BL_Human1.87413289
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.82885513
27TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80042090
28MYC_19079543_ChIP-ChIP_MESCs_Mouse1.78777457
29FUS_26573619_Chip-Seq_HEK293_Human1.78157318
30CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.76714036
31CLOCK_20551151_ChIP-Seq_293T_Human1.74585868
32PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.71294926
33STAT3_1855785_ChIP-Seq_MESCs_Mouse1.65416247
34FOXM1_26456572_ChIP-Seq_MCF-7_Human1.64005075
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61922406
36MYC_19030024_ChIP-ChIP_MESCs_Mouse1.61096521
37NELFA_20434984_ChIP-Seq_ESCs_Mouse1.57139491
38GABP_17652178_ChIP-ChIP_JURKAT_Human1.53676244
39EWS_26573619_Chip-Seq_HEK293_Human1.53000344
40* E2F1_21310950_ChIP-Seq_MCF-7_Human1.52103410
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.52013710
42MYC_18358816_ChIP-ChIP_MESCs_Mouse1.49984191
43STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.49847335
44FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.49489229
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.44728776
46CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.44403404
47SALL4_18804426_ChIP-ChIP_XEN_Mouse1.40539704
48* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.39079586
49ESR1_15608294_ChIP-ChIP_MCF-7_Human1.38189834
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.35770281
51YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34683577
52POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.27175028
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.26556712
54HIF1A_21447827_ChIP-Seq_MCF-7_Human1.26443606
55NOTCH1_21737748_ChIP-Seq_TLL_Human1.25745677
56FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.25520541
57* XRN2_22483619_ChIP-Seq_HELA_Human1.23244790
58ATF3_27146783_Chip-Seq_COLON_Human1.23104689
59KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.22371989
60ZFX_18555785_ChIP-Seq_MESCs_Mouse1.22213960
61TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.20798118
62E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.19788061
63GATA1_22025678_ChIP-Seq_K562_Human1.18560390
64DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.18533173
65FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17663993
66KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16794406
67BRD4_25478319_ChIP-Seq_HGPS_Human1.16452519
68TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16250962
69ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.15920947
70CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15340821
71RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.14880083
72EZH2_27294783_Chip-Seq_NPCs_Mouse1.14277579
73VDR_22108803_ChIP-Seq_LS180_Human1.13744634
74NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.13398238
75NANOG_16153702_ChIP-ChIP_HESCs_Human1.12205526
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11990265
77CREB1_15753290_ChIP-ChIP_HEK293T_Human1.11328751
78KDM5A_27292631_Chip-Seq_BREAST_Human1.10014878
79HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.08550755
80HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06596739
81EP300_21415370_ChIP-Seq_HL-1_Mouse1.06104903
82CHD1_26751641_Chip-Seq_LNCaP_Human1.04984206
83* GATA3_24758297_ChIP-Seq_MCF-7_Human1.04599088
84ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04230608
85PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03243805
86GATA6_25053715_ChIP-Seq_YYC3_Human1.02419229
87FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.01700554
88ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00853228
89MYB_21317192_ChIP-Seq_ERMYB_Mouse1.00111140
90PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99808431
91SOX17_20123909_ChIP-Seq_XEN_Mouse0.99699795
92PIAS1_25552417_ChIP-Seq_VCAP_Human0.98917912
93JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.98778289
94E2F1_18555785_ChIP-Seq_MESCs_Mouse0.97242253
95SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.97067919
96TCF7_22412390_ChIP-Seq_EML_Mouse0.97042725
97TAF15_26573619_Chip-Seq_HEK293_Human0.96743856
98FOXO3_23340844_ChIP-Seq_DLD1_Human0.96641937
99KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95939094
100BRD4_27068464_Chip-Seq_AML-cells_Mouse0.94771289
101NANOG_18555785_ChIP-Seq_MESCs_Mouse0.94297909
102CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.94232643
103HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.94223103
104SALL4_22934838_ChIP-ChIP_CD34+_Human0.93479408
105ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.93181669
106* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92686581
107TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.92643123
108MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.92599072
109FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.92319409
110DCP1A_22483619_ChIP-Seq_HELA_Human0.91794348
111VDR_21846776_ChIP-Seq_THP-1_Human0.91628092
112POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.90818296
113ESR1_20079471_ChIP-ChIP_T-47D_Human0.90094644
114SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.89826387
115SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.89516913
116ELF1_17652178_ChIP-ChIP_JURKAT_Human0.88820162
117* TP63_23658742_ChIP-Seq_EP156T_Human0.88200035
118* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.88038828
119ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.87670570
120MYB_26560356_Chip-Seq_TH1_Human0.87461136
121UTX_26944678_Chip-Seq_JUKART_Human0.86853817
122MAF_26560356_Chip-Seq_TH1_Human0.86615167
123CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.86398573
124FOXP3_21729870_ChIP-Seq_TREG_Human0.86395587
125TCF4_18268006_ChIP-ChIP_LS174T_Human0.86300260
126CDX2_22108803_ChIP-Seq_LS180_Human0.85608322
127SOX2_27498859_Chip-Seq_STOMACH_Mouse0.85385431
128MYC_18940864_ChIP-ChIP_HL60_Human0.85375932
129P300_19829295_ChIP-Seq_ESCs_Human0.85194866
130SUZ12_27294783_Chip-Seq_NPCs_Mouse0.85043032
131* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.84072926
132* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.84072926
133ETS1_20019798_ChIP-Seq_JURKAT_Human0.83816529
134SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.83245456
135BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.83060669
136NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.82191996
137GATA4_21415370_ChIP-Seq_HL-1_Mouse0.82179610
138FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.81855675
139GATA4_25053715_ChIP-Seq_YYC3_Human0.81766564
140HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.81741201
141CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.81652858
142* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.81623667
143KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.81467057
144TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.81109814
145PCGF2_27294783_Chip-Seq_NPCs_Mouse0.81034291
146KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.80973485
147* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.80748335
148TFEB_21752829_ChIP-Seq_HELA_Human0.80230478
149P63_26484246_Chip-Seq_KERATINOCYTES_Human0.80022377
150CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.79729310
151POU5F1_16153702_ChIP-ChIP_HESCs_Human0.79697833
152EST1_17652178_ChIP-ChIP_JURKAT_Human0.79091336
153SCL_19346495_ChIP-Seq_HPC-7_Human0.77859769
154* GABP_19822575_ChIP-Seq_HepG2_Human0.77754894
155RACK7_27058665_Chip-Seq_MCF-7_Human0.77562272
156NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.77436322
157CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.76225027
158VDR_23849224_ChIP-Seq_CD4+_Human0.76172007
159FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.76076539
160KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.75642716

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier3.96007003
2MP0010234_abnormal_vibrissa_follicle3.59271162
3MP0002139_abnormal_hepatobiliary_system3.28626759
4MP0003705_abnormal_hypodermis_morpholog3.14024567
5MP0003806_abnormal_nucleotide_metabolis3.08031474
6MP0005360_urolithiasis3.01906199
7MP0005275_abnormal_skin_tensile2.70076524
8MP0009697_abnormal_copulation2.66295702
9MP0005365_abnormal_bile_salt2.60630993
10MP0005501_abnormal_skin_physiology2.57050523
11MP0005085_abnormal_gallbladder_physiolo2.54179607
12MP0010352_gastrointestinal_tract_polyps2.45752652
13MP0003718_maternal_effect2.44363567
14MP0005451_abnormal_body_composition2.07453366
15MP0003890_abnormal_embryonic-extraembry1.95143941
16MP0010094_abnormal_chromosome_stability1.87218845
17MP0000749_muscle_degeneration1.84094350
18MP0002009_preneoplasia1.83474817
19MP0002060_abnormal_skin_morphology1.82914419
20MP0003252_abnormal_bile_duct1.75106849
21MP0001216_abnormal_epidermal_layer1.72350517
22MP0008875_abnormal_xenobiotic_pharmacok1.72320335
23MP0008932_abnormal_embryonic_tissue1.71961204
24MP0004957_abnormal_blastocyst_morpholog1.68003481
25MP0003191_abnormal_cellular_cholesterol1.66958617
26MP0001661_extended_life_span1.66231181
27MP0010329_abnormal_lipoprotein_level1.61896802
28MP0004947_skin_inflammation1.60495443
29MP0000579_abnormal_nail_morphology1.55848269
30MP0000377_abnormal_hair_follicle1.51668024
31MP0003693_abnormal_embryo_hatching1.50512546
32MP0008057_abnormal_DNA_replication1.49790628
33MP0003566_abnormal_cell_adhesion1.49562929
34MP0003111_abnormal_nucleus_morphology1.46848065
35MP0009840_abnormal_foam_cell1.46817395
36MP0004185_abnormal_adipocyte_glucose1.45798713
37MP0010678_abnormal_skin_adnexa1.39992980
38MP0001666_abnormal_nutrient_absorption1.39963114
39MP0010307_abnormal_tumor_latency1.38804497
40MP0003453_abnormal_keratinocyte_physiol1.36580409
41MP0000427_abnormal_hair_cycle1.34258590
42MP0003646_muscle_fatigue1.33566947
43MP0010368_abnormal_lymphatic_system1.30829781
44MP0003077_abnormal_cell_cycle1.30191774
45MP0001730_embryonic_growth_arrest1.28918662
46MP0000609_abnormal_liver_physiology1.28335203
47MP0006054_spinal_hemorrhage1.27860108
48MP0005666_abnormal_adipose_tissue1.24346251
49MP0000647_abnormal_sebaceous_gland1.24290846
50MP0002254_reproductive_system_inflammat1.23545769
51MP0003941_abnormal_skin_development1.21608703
52MP0003656_abnormal_erythrocyte_physiolo1.20544655
53MP0004272_abnormal_basement_membrane1.19914075
54MP0010771_integument_phenotype1.19753898
55MP0005083_abnormal_biliary_tract1.18048440
56MP0004264_abnormal_extraembryonic_tissu1.16922440
57MP0004036_abnormal_muscle_relaxation1.15191176
58MP0002234_abnormal_pharynx_morphology1.14271921
59MP0005076_abnormal_cell_differentiation1.13190134
60MP0005332_abnormal_amino_acid1.12865095
61MP0002396_abnormal_hematopoietic_system1.12310941
62MP0003300_gastrointestinal_ulcer1.12305405
63MP0002098_abnormal_vibrissa_morphology1.12192829
64MP0003011_delayed_dark_adaptation1.11620976
65MP0003937_abnormal_limbs/digits/tail_de1.09183999
66MP0005319_abnormal_enzyme/_coenzyme1.07895969
67MP0004215_abnormal_myocardial_fiber1.06517317
68MP0009931_abnormal_skin_appearance1.06435167
69MP0000383_abnormal_hair_follicle1.05443938
70MP0008007_abnormal_cellular_replicative1.01222383
71MP0004197_abnormal_fetal_growth/weight/1.01122171
72MP0004130_abnormal_muscle_cell1.00943762
73MP0005023_abnormal_wound_healing1.00409458
74MP0004233_abnormal_muscle_weight0.98435888
75MP0005330_cardiomyopathy0.98030655
76MP0002166_altered_tumor_susceptibility0.97270474
77MP0002085_abnormal_embryonic_tissue0.97176140
78MP0005395_other_phenotype0.96745117
79MP0000350_abnormal_cell_proliferation0.96277756
80MP0000762_abnormal_tongue_morphology0.95635250
81MP0009672_abnormal_birth_weight0.95505992
82MP0002269_muscular_atrophy0.94390484
83MP0005670_abnormal_white_adipose0.94132119
84MP0001243_abnormal_dermal_layer0.93407206
85MP0004782_abnormal_surfactant_physiolog0.93061814
86MP0002160_abnormal_reproductive_system0.92809948
87MP0002118_abnormal_lipid_homeostasis0.92424275
88MP0001191_abnormal_skin_condition0.92364229
89MP0002877_abnormal_melanocyte_morpholog0.91403698
90MP0005408_hypopigmentation0.89777665
91MP0000598_abnormal_liver_morphology0.89248202
92MP0000428_abnormal_craniofacial_morphol0.88774796
93MP0003567_abnormal_fetal_cardiomyocyte0.88274868
94MP0002086_abnormal_extraembryonic_tissu0.87912781
95MP0003984_embryonic_growth_retardation0.87869976
96MP0000467_abnormal_esophagus_morphology0.87704266
97MP0005380_embryogenesis_phenotype0.87483002
98MP0001672_abnormal_embryogenesis/_devel0.87483002
99MP0002088_abnormal_embryonic_growth/wei0.87363623
100MP0002233_abnormal_nose_morphology0.86921675
101MP0003221_abnormal_cardiomyocyte_apopto0.85354138
102MP0003950_abnormal_plasma_membrane0.85022561
103MP0009379_abnormal_foot_pigmentation0.84602644
104MP0004381_abnormal_hair_follicle0.83147689
105MP0000627_abnormal_mammary_gland0.82621470
106MP0002019_abnormal_tumor_incidence0.81876793
107MP0006036_abnormal_mitochondrial_physio0.81820170
108MP0002697_abnormal_eye_size0.80758405
109MP0010630_abnormal_cardiac_muscle0.80348141
110MP0005410_abnormal_fertilization0.79152899
111MP0004084_abnormal_cardiac_muscle0.78571907
112MP0000015_abnormal_ear_pigmentation0.78545842
113MP0002080_prenatal_lethality0.78374508
114MP0000372_irregular_coat_pigmentation0.78051629
115MP0000747_muscle_weakness0.77607960
116MP0001697_abnormal_embryo_size0.77396529
117MP0002006_tumorigenesis0.76014856
118MP0001286_abnormal_eye_development0.75801524
119MP0005647_abnormal_sex_gland0.75459167
120MP0003186_abnormal_redox_activity0.75120204
121MP0000367_abnormal_coat/_hair0.74931647
122MP0004087_abnormal_muscle_fiber0.73952669
123MP0004145_abnormal_muscle_electrophysio0.73890176
124MP0001293_anophthalmia0.73718382
125MP0003786_premature_aging0.73026013
126MP0004019_abnormal_vitamin_homeostasis0.71502727
127MP0000678_abnormal_parathyroid_gland0.71167306
128MP0001915_intracranial_hemorrhage0.70550017
129MP0000432_abnormal_head_morphology0.70277411
130MP0002111_abnormal_tail_morphology0.70036653
131MP0004808_abnormal_hematopoietic_stem0.69917042
132MP0009053_abnormal_anal_canal0.69622233
133MP0005409_darkened_coat_color0.69145603
134MP0003943_abnormal_hepatobiliary_system0.69008666
135MP0000465_gastrointestinal_hemorrhage0.68370932
136MP0002837_dystrophic_cardiac_calcinosis0.68309861
137MP0001784_abnormal_fluid_regulation0.68306165
138MP0003763_abnormal_thymus_physiology0.68239417
139MP0002177_abnormal_outer_ear0.68197804
140MP0002084_abnormal_developmental_patter0.67720620
141MP0005220_abnormal_exocrine_pancreas0.67663469
142MP0008058_abnormal_DNA_repair0.65968639

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of nail color (HP:0100643)4.35405421
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.27280574
3Chromsome breakage (HP:0040012)4.18225277
4Intrahepatic cholestasis (HP:0001406)4.04582119
5Abnormality of monocarboxylic acid metabolism (HP:0010996)3.86346657
6Deep venous thrombosis (HP:0002625)3.69522450
7Hypobetalipoproteinemia (HP:0003563)3.55446275
8Increased IgE level (HP:0003212)3.51512513
9Papillary thyroid carcinoma (HP:0002895)3.46665806
10Right ventricular cardiomyopathy (HP:0011663)3.36472219
11Xanthomatosis (HP:0000991)3.30632652
12Myoglobinuria (HP:0002913)3.29573904
13Exercise-induced muscle cramps (HP:0003710)3.27823625
14Hyperammonemia (HP:0001987)3.18842803
15Oral leukoplakia (HP:0002745)3.18060475
16Hypolipoproteinemia (HP:0010981)3.17239312
17Rhabdomyolysis (HP:0003201)3.14476002
18Conjunctival hamartoma (HP:0100780)3.14322811
19Hyporeflexia of lower limbs (HP:0002600)3.14192312
20Hypophosphatemic rickets (HP:0004912)3.06030860
21Hypoalphalipoproteinemia (HP:0003233)3.05546421
22Epidermoid cyst (HP:0200040)2.90880578
23Hypoglycemic coma (HP:0001325)2.89235593
24Spastic diplegia (HP:0001264)2.86999972
25Male infertility (HP:0003251)2.83863992
26Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.77372547
27Palmoplantar hyperkeratosis (HP:0000972)2.69898681
28Plantar hyperkeratosis (HP:0007556)2.67545887
29Increased connective tissue (HP:0009025)2.65930698
30Abnormality of glycine metabolism (HP:0010895)2.64130856
31Abnormality of serine family amino acid metabolism (HP:0010894)2.64130856
32Hyperglycinuria (HP:0003108)2.62372463
33Abnormality of pyrimidine metabolism (HP:0004353)2.62165042
34Ketosis (HP:0001946)2.60956323
35Abnormality of sulfur amino acid metabolism (HP:0004339)2.60663738
36Abnormality of aromatic amino acid family metabolism (HP:0004338)2.58039777
37Palmar hyperkeratosis (HP:0010765)2.56586809
38Amniotic constriction ring (HP:0009775)2.53853054
39Abnormality of placental membranes (HP:0011409)2.53853054
40Hyperlipoproteinemia (HP:0010980)2.53806929
41Selective tooth agenesis (HP:0001592)2.51105572
42Ulnar deviation of the wrist (HP:0003049)2.50828311
43Exercise-induced myalgia (HP:0003738)2.49617054
44Gangrene (HP:0100758)2.49439043
45Onycholysis (HP:0001806)2.43742092
46Biliary tract neoplasm (HP:0100574)2.43527829
47Hypotrichosis (HP:0001006)2.42857938
48Hyperglycinemia (HP:0002154)2.41030608
49Abnormality of chromosome stability (HP:0003220)2.39152066
50Woolly hair (HP:0002224)2.38497111
51Abnormality of the preputium (HP:0100587)2.37854679
52Corneal erosion (HP:0200020)2.37273950
53Osteolytic defects of the hand bones (HP:0009699)2.34220354
54Osteolytic defects of the phalanges of the hand (HP:0009771)2.34220354
55Abnormality of methionine metabolism (HP:0010901)2.34208310
56Complement deficiency (HP:0004431)2.34197215
57Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.31918954
58Abnormality of fatty-acid metabolism (HP:0004359)2.30438525
59Thyroid carcinoma (HP:0002890)2.30403815
60Fat malabsorption (HP:0002630)2.26812574
61Aplasia/Hypoplasia of the uvula (HP:0010293)2.20110820
62Milia (HP:0001056)2.20039930
63Pili torti (HP:0003777)2.19925857
64Generalized aminoaciduria (HP:0002909)2.19272978
65Erythema (HP:0010783)2.16916548
66Adenoma sebaceum (HP:0009720)2.16679568
67Angiofibromas (HP:0010615)2.16679568
68Abnormality of the common coagulation pathway (HP:0010990)2.16231459
69Ependymoma (HP:0002888)2.15853308
70Nephroblastoma (Wilms tumor) (HP:0002667)2.14952330
71Abnormality of aspartate family amino acid metabolism (HP:0010899)2.14607407
72Hypoglycemic seizures (HP:0002173)2.14453856
73Muscle fiber inclusion bodies (HP:0100299)2.14087864
74Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.11989933
75Embryonal renal neoplasm (HP:0011794)2.11555191
76Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.08188601
77Acute myeloid leukemia (HP:0004808)2.06961693
78Increased serum pyruvate (HP:0003542)2.06535881
79Congenital ichthyosiform erythroderma (HP:0007431)2.06006593
80Hypercholesterolemia (HP:0003124)2.05836869
81Hamartoma of the eye (HP:0010568)2.05818018
82Abnormality of the Achilles tendon (HP:0005109)2.02794669
83Blepharitis (HP:0000498)2.02581909
84Secondary amenorrhea (HP:0000869)2.02112806
85Birth length less than 3rd percentile (HP:0003561)2.01106562
86Colon cancer (HP:0003003)1.99172352
87Abnormalities of placenta or umbilical cord (HP:0001194)1.98913583
88Steatorrhea (HP:0002570)1.97914438
89Hypoplastic labia majora (HP:0000059)1.97831466
90Subaortic stenosis (HP:0001682)1.97247637
91Abnormality of the left ventricular outflow tract (HP:0011103)1.97247637
92Nail dystrophy (HP:0008404)1.97005983
93Bundle branch block (HP:0011710)1.96175967
94Abnormality of the costochondral junction (HP:0000919)1.93989417
95Abnormality of the axillary hair (HP:0100134)1.93375069
96Abnormality of secondary sexual hair (HP:0009888)1.93375069
97Abnormality of glycolysis (HP:0004366)1.92735881
98Areflexia of lower limbs (HP:0002522)1.92263556
99Alopecia of scalp (HP:0002293)1.92210100
100Distal arthrogryposis (HP:0005684)1.92152007
101Abnormality of glutamine family amino acid metabolism (HP:0010902)1.91482363
102Hepatocellular carcinoma (HP:0001402)1.91203521
103Ventricular tachycardia (HP:0004756)1.90647077
104Nemaline bodies (HP:0003798)1.89907192
105Abnormal blistering of the skin (HP:0008066)1.89897675
106Acanthosis nigricans (HP:0000956)1.89583772
107Abnormality of the intrinsic pathway (HP:0010989)1.88569695
108Popliteal pterygium (HP:0009756)1.88467261
109Ectropion (HP:0000656)1.88288769
110Ketoacidosis (HP:0001993)1.86499959
111Back pain (HP:0003418)1.86059715
112Palmoplantar keratoderma (HP:0000982)1.84259309
113Abnormal hair laboratory examination (HP:0003328)1.83977720
114Premature ovarian failure (HP:0008209)1.83749662
115Curly hair (HP:0002212)1.83595024
116Acanthocytosis (HP:0001927)1.83569835
117Difficulty running (HP:0009046)1.83234333
118Lip pit (HP:0100267)1.82971555
119Abnormality of serum amino acid levels (HP:0003112)1.82729598
120Abnormality of complement system (HP:0005339)1.82344491
121Erythroderma (HP:0001019)1.80995751
122Neoplasm of the rectum (HP:0100743)1.80990668
123Sparse eyelashes (HP:0000653)1.80954358
124Natal tooth (HP:0000695)1.80331977
125Reduced antithrombin III activity (HP:0001976)1.80039015
126Abnormality of nucleobase metabolism (HP:0010932)1.80037604
127Abnormal cartilage morphology (HP:0002763)1.79615239
128Meckel diverticulum (HP:0002245)1.79337843
129Abnormality of the labia majora (HP:0012881)1.79183294
130Septate vagina (HP:0001153)1.79006504
131Dicarboxylic aciduria (HP:0003215)1.78754605
132Abnormality of dicarboxylic acid metabolism (HP:0010995)1.78754605
133Multiple enchondromatosis (HP:0005701)1.78579049
134Deviation of the thumb (HP:0009603)1.78496130
135Neonatal onset (HP:0003623)1.77704099
136Breast carcinoma (HP:0003002)1.77143143
137Abnormality of the calcaneus (HP:0008364)1.76912143
138Cystic hygroma (HP:0000476)1.76707184
139Calf muscle hypertrophy (HP:0008981)1.76208600
140Abnormal biliary tract morphology (HP:0012440)1.75939183
141Ankyloglossia (HP:0010296)1.74441753
142Acute lymphatic leukemia (HP:0006721)1.73261947
143Myocardial infarction (HP:0001658)1.73260677
144Achilles tendon contracture (HP:0001771)1.73019902
145Volvulus (HP:0002580)1.71850268
146Esophageal varix (HP:0002040)1.71677512
147Muscle hypertrophy of the lower extremities (HP:0008968)1.71444750
148Microglossia (HP:0000171)1.71260519
149Prolonged partial thromboplastin time (HP:0003645)1.70854511
150Proximal placement of thumb (HP:0009623)1.68922811
151Lack of skin elasticity (HP:0100679)1.68422230
152Type 1 muscle fiber predominance (HP:0003803)1.68347526
153Duplicated collecting system (HP:0000081)1.68185976
154Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.66464951
155Abnormality of alanine metabolism (HP:0010916)1.66464951
156Hyperalaninemia (HP:0003348)1.66464951
157Recurrent corneal erosions (HP:0000495)1.66198767
158Rhabdomyosarcoma (HP:0002859)1.66195413
159Abnormality of the calf musculature (HP:0001430)1.65948466
160Conjugated hyperbilirubinemia (HP:0002908)1.65712155
161Duodenal stenosis (HP:0100867)1.65495995
162Small intestinal stenosis (HP:0012848)1.65495995
163Absent eyelashes (HP:0000561)1.64764548
164Abnormality of the ileum (HP:0001549)1.64481736
165Facial cleft (HP:0002006)1.63752565
166Symptomatic seizures (HP:0011145)1.62155762
167Advanced eruption of teeth (HP:0006288)1.60777832
168Asymmetry of the thorax (HP:0001555)1.59840454

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PKN23.66634326
2PBK3.26736936
3EEF2K3.10818205
4PDK32.89814448
5PDK42.89814448
6MST42.82370722
7TRIB32.82217928
8BCKDK2.71032488
9CDC72.49186384
10NEK12.35113632
11RPS6KB22.22395894
12TTN2.15626525
13TIE12.15613882
14LATS12.07965169
15STK38L2.07175591
16ERN12.05894571
17PDK22.03572687
18WEE11.97529247
19FLT31.95777774
20CDK121.94290689
21TAF11.94199552
22NUAK11.89609732
23NEK21.84445259
24MAPKAPK31.84299607
25BUB11.81894516
26SCYL21.78633509
27TTK1.72396852
28STK101.71850329
29PLK31.58751716
30EPHA21.53879173
31LRRK21.52079000
32STK31.51464596
33CDK61.45073449
34MAP2K31.44579647
35ERBB31.43068104
36ACVR1B1.42280751
37NEK91.40890636
38TRIM281.37323824
39SIK11.34143320
40CDK41.32231877
41TESK11.31403976
42PTK61.30271520
43MAP3K101.29715826
44FGFR41.28080932
45EIF2AK21.23662552
46STK391.23484135
47RPS6KA41.23302534
48MKNK21.18644041
49MAP3K81.17744664
50MAP3K31.14492798
51MKNK11.12724545
52PRKG21.11576159
53ATR1.08581001
54RIPK11.08250475
55MAP3K121.07790051
56BMPR1B1.07424894
57FGFR11.04640419
58TGFBR11.04356620
59PIK3CG1.03700167
60MTOR0.98432698
61MST1R0.97885543
62AURKB0.96152388
63PASK0.93708797
64STK40.90741887
65OBSCN0.86728558
66CDK70.86634249
67PLK40.85851069
68TSSK60.85590840
69SMG10.83654220
70PAK40.82317276
71TNIK0.81245245
72MAPK110.81196605
73DYRK30.79866490
74DMPK0.79028426
75MAP4K10.76706718
76FGFR30.76010918
77MAP3K70.74251388
78CHEK10.73832013
79DYRK1B0.71869923
80BRSK20.71007400
81FER0.69425264
82PRKAA20.68853236
83ICK0.67863346
84CDK80.65766576
85MAP3K50.63856754
86MET0.63677027
87BCR0.62904577
88ATM0.62267529
89NME10.61151958
90PHKG10.60379754
91PLK10.60333312
92JAK30.60241986
93CAMK1G0.60154957
94TRPM70.59034362
95TYK20.58962535
96MAP2K60.56688158
97PAK20.55899472
98CDK30.54688130
99TESK20.54686182
100EIF2AK10.54094257
101ZAP700.53865408
102VRK10.53511568
103KDR0.53284910
104BRD40.53041119
105EIF2AK30.52380944
106ALK0.52020693
107STK240.51981831
108CAMK1D0.51904659
109TGFBR20.51864090
110LATS20.51844250
111PDGFRA0.50742116
112CSNK1D0.49433462
113NEK60.48900848
114TAOK30.48775971
115TEC0.47999705
116PIM10.47079075
117CDK20.46951090
118BRSK10.45587159
119AURKA0.45530048
120MAPKAPK50.45151502
121VRK20.45038058
122FRK0.44733732
123BTK0.43696551
124NLK0.39042188
125RPS6KB10.38990435
126JAK20.38918195
127SRPK10.38785042
128BMX0.37167144
129CDK10.37157328
130CDK90.34852761
131AKT20.34275136
132MAP3K20.34067136
133TAOK20.33925943
134PNCK0.33720360
135ITK0.32485409
136CHEK20.32464521
137ERBB40.32296542
138ILK0.32068202
139ZAK0.30937908
140PRKAA10.30843494
141CSNK2A20.30497671
142LMTK20.30208102
143MELK0.30153642
144PHKG20.28570145
145PIK3CA0.28346382
146MUSK0.28080210

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.03038563
2Fatty acid degradation_Homo sapiens_hsa000712.55486078
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.47950538
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.47585580
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.44474077
6One carbon pool by folate_Homo sapiens_hsa006702.41934803
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.30809425
8Propanoate metabolism_Homo sapiens_hsa006402.28616384
9Selenocompound metabolism_Homo sapiens_hsa004502.24156911
10DNA replication_Homo sapiens_hsa030302.23375271
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.17064603
12Biosynthesis of amino acids_Homo sapiens_hsa012302.16330126
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.14922937
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.13639529
15Carbon metabolism_Homo sapiens_hsa012002.04713364
16Proteasome_Homo sapiens_hsa030502.02538051
17Cyanoamino acid metabolism_Homo sapiens_hsa004602.02198427
18Basal transcription factors_Homo sapiens_hsa030222.01399420
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.01304576
20Arginine biosynthesis_Homo sapiens_hsa002201.99830690
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.91095257
22Fatty acid metabolism_Homo sapiens_hsa012121.84887728
23Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.77502162
24Mismatch repair_Homo sapiens_hsa034301.74127576
25Pyruvate metabolism_Homo sapiens_hsa006201.65960861
26Pentose phosphate pathway_Homo sapiens_hsa000301.65500394
27Sulfur metabolism_Homo sapiens_hsa009201.65324469
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.60131349
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.58479644
30PPAR signaling pathway_Homo sapiens_hsa033201.55993123
31Tryptophan metabolism_Homo sapiens_hsa003801.54944642
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.45773490
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.41687068
34Protein export_Homo sapiens_hsa030601.40807984
35Pentose and glucuronate interconversions_Homo sapiens_hsa000401.37905196
36Fat digestion and absorption_Homo sapiens_hsa049751.34925627
37Fatty acid biosynthesis_Homo sapiens_hsa000611.33691005
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.27180125
39Complement and coagulation cascades_Homo sapiens_hsa046101.27126209
40TGF-beta signaling pathway_Homo sapiens_hsa043501.26464210
41beta-Alanine metabolism_Homo sapiens_hsa004101.25424719
42RNA transport_Homo sapiens_hsa030131.24957349
43Peroxisome_Homo sapiens_hsa041461.22161922
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.17290689
45Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.16729281
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.15046944
47Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.10083553
48Chemical carcinogenesis_Homo sapiens_hsa052041.08786262
49Caffeine metabolism_Homo sapiens_hsa002321.08076823
50Starch and sucrose metabolism_Homo sapiens_hsa005001.06581967
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.05984595
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.05804502
53N-Glycan biosynthesis_Homo sapiens_hsa005101.03742419
54ABC transporters_Homo sapiens_hsa020101.03608567
55Lysine degradation_Homo sapiens_hsa003101.02334122
56Base excision repair_Homo sapiens_hsa034100.94516954
57Histidine metabolism_Homo sapiens_hsa003400.92516696
58Phenylalanine metabolism_Homo sapiens_hsa003600.92494979
59Glutathione metabolism_Homo sapiens_hsa004800.91508984
60Retinol metabolism_Homo sapiens_hsa008300.91467402
61Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.89978138
62Cell cycle_Homo sapiens_hsa041100.89006665
63Folate biosynthesis_Homo sapiens_hsa007900.88060833
64Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.85414668
65Fatty acid elongation_Homo sapiens_hsa000620.84681085
66Butanoate metabolism_Homo sapiens_hsa006500.84640225
67RNA polymerase_Homo sapiens_hsa030200.84016241
68Glycerolipid metabolism_Homo sapiens_hsa005610.79093957
69Nucleotide excision repair_Homo sapiens_hsa034200.78416960
70Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77631152
71Oocyte meiosis_Homo sapiens_hsa041140.77382635
72Central carbon metabolism in cancer_Homo sapiens_hsa052300.74746156
73Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.72701990
74Hippo signaling pathway_Homo sapiens_hsa043900.71005855
75Circadian rhythm_Homo sapiens_hsa047100.70186616
76Fructose and mannose metabolism_Homo sapiens_hsa000510.69643781
77Bile secretion_Homo sapiens_hsa049760.69269305
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68989302
79Tyrosine metabolism_Homo sapiens_hsa003500.68068947
80Non-homologous end-joining_Homo sapiens_hsa034500.65898786
81Homologous recombination_Homo sapiens_hsa034400.65243900
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.64153680
83Arginine and proline metabolism_Homo sapiens_hsa003300.63309580
84Insulin resistance_Homo sapiens_hsa049310.62044464
85Staphylococcus aureus infection_Homo sapiens_hsa051500.62003098
86p53 signaling pathway_Homo sapiens_hsa041150.61726386
87Purine metabolism_Homo sapiens_hsa002300.61518583
88Spliceosome_Homo sapiens_hsa030400.60756197
89Tight junction_Homo sapiens_hsa045300.60531152
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59542427
91Vitamin B6 metabolism_Homo sapiens_hsa007500.59154504
92Systemic lupus erythematosus_Homo sapiens_hsa053220.58956817
93ECM-receptor interaction_Homo sapiens_hsa045120.58033031
94MicroRNAs in cancer_Homo sapiens_hsa052060.56527341
95Linoleic acid metabolism_Homo sapiens_hsa005910.56489508
96Sphingolipid metabolism_Homo sapiens_hsa006000.56424552
97Pyrimidine metabolism_Homo sapiens_hsa002400.55409825
98Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.54852635
99Galactose metabolism_Homo sapiens_hsa000520.54153537
100Glucagon signaling pathway_Homo sapiens_hsa049220.53371073
101AMPK signaling pathway_Homo sapiens_hsa041520.51933803
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50482545
103Small cell lung cancer_Homo sapiens_hsa052220.50032798
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.49755262
105Antigen processing and presentation_Homo sapiens_hsa046120.47963885
106Viral carcinogenesis_Homo sapiens_hsa052030.45744732
107RNA degradation_Homo sapiens_hsa030180.44802399
108Dilated cardiomyopathy_Homo sapiens_hsa054140.43676240
109Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43309111
110Proteoglycans in cancer_Homo sapiens_hsa052050.42699477
111mRNA surveillance pathway_Homo sapiens_hsa030150.41972336
112Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41948273
113Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39477260
114Inositol phosphate metabolism_Homo sapiens_hsa005620.38538784
115Vitamin digestion and absorption_Homo sapiens_hsa049770.37586390
116Sulfur relay system_Homo sapiens_hsa041220.36449109
117Legionellosis_Homo sapiens_hsa051340.35112378
118Ether lipid metabolism_Homo sapiens_hsa005650.32601554
119Adherens junction_Homo sapiens_hsa045200.31783437
120Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31442555
121Ribosome_Homo sapiens_hsa030100.31247074
122Steroid biosynthesis_Homo sapiens_hsa001000.31062938
123mTOR signaling pathway_Homo sapiens_hsa041500.30510786
124Fanconi anemia pathway_Homo sapiens_hsa034600.30001303
125Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.28041210
126Metabolic pathways_Homo sapiens_hsa011000.27165160
127Insulin signaling pathway_Homo sapiens_hsa049100.26249869
128Thyroid cancer_Homo sapiens_hsa052160.23713499

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »