IDH2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)7.24007743
2cardiac myofibril assembly (GO:0055003)7.16607793
3* tricarboxylic acid cycle (GO:0006099)6.80846579
4skeletal muscle contraction (GO:0003009)6.60822177
5myofibril assembly (GO:0030239)6.05133830
6negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.86163468
7muscle filament sliding (GO:0030049)5.69383753
8actin-myosin filament sliding (GO:0033275)5.69383753
9cardiac muscle cell development (GO:0055013)5.51532454
10negative regulation of potassium ion transmembrane transport (GO:1901380)5.45407956
11cardiac muscle contraction (GO:0060048)5.35820159
12deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.18129032
13cardiac cell development (GO:0055006)5.17453040
14oxidative phosphorylation (GO:0006119)5.16899925
15regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.16896867
16response to stimulus involved in regulation of muscle adaptation (GO:0014874)5.04254076
17carnitine shuttle (GO:0006853)4.88852707
18mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.85508616
19heart contraction (GO:0060047)4.75503284
20heart process (GO:0003015)4.75503284
21cardiac muscle tissue morphogenesis (GO:0055008)4.66765899
22lysine metabolic process (GO:0006553)4.65046472
23lysine catabolic process (GO:0006554)4.65046472
24ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.60207606
25actin-mediated cell contraction (GO:0070252)4.59716707
26regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.59116648
27regulation of sarcomere organization (GO:0060297)4.58365851
28heart trabecula formation (GO:0060347)4.54691359
29bundle of His cell to Purkinje myocyte communication (GO:0086069)4.51652893
30actomyosin structure organization (GO:0031032)4.50450540
31regulation of acyl-CoA biosynthetic process (GO:0050812)4.50256848
32NADH metabolic process (GO:0006734)4.49482333
33cardiac muscle hypertrophy (GO:0003300)4.49050242
34regulation of actin filament-based movement (GO:1903115)4.47741476
35adult heart development (GO:0007512)4.42866805
36energy coupled proton transport, down electrochemical gradient (GO:0015985)4.42839918
37ATP synthesis coupled proton transport (GO:0015986)4.42839918
38regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.39717495
39fatty acid transmembrane transport (GO:1902001)4.33737125
40regulation of coenzyme metabolic process (GO:0051196)4.32888365
41regulation of cofactor metabolic process (GO:0051193)4.32888365
42ventricular cardiac muscle cell action potential (GO:0086005)4.32049606
43regulation of relaxation of muscle (GO:1901077)4.29474258
44fatty acid beta-oxidation (GO:0006635)4.28685293
45striated muscle hypertrophy (GO:0014897)4.22609503
46positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.19525417
47muscle tissue morphogenesis (GO:0060415)4.15140566
48negative regulation of cell size (GO:0045792)4.12865019
49regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.12599248
50regulation of skeletal muscle contraction (GO:0014819)4.10483207
51regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.98939690
52aspartate family amino acid catabolic process (GO:0009068)3.97983870
53response to inactivity (GO:0014854)3.96000676
54striated muscle contraction (GO:0006941)3.92399485
55plasma membrane repair (GO:0001778)3.90846160
56* 2-oxoglutarate metabolic process (GO:0006103)3.89679201
57branched-chain amino acid catabolic process (GO:0009083)3.84452236
58purine nucleotide salvage (GO:0032261)3.83789559
59respiratory electron transport chain (GO:0022904)3.81308440
60ventricular cardiac muscle cell development (GO:0055015)3.81285155
61oxaloacetate metabolic process (GO:0006107)3.79379053
62gluconeogenesis (GO:0006094)3.73465278
63carnitine transmembrane transport (GO:1902603)3.72304158
64muscle hypertrophy (GO:0014896)3.71922061
65electron transport chain (GO:0022900)3.70669773
66succinate metabolic process (GO:0006105)3.70601350
67skeletal muscle adaptation (GO:0043501)3.69696346
68* tricarboxylic acid metabolic process (GO:0072350)3.65707662
69regulation of the force of heart contraction (GO:0002026)3.64343478
70valine metabolic process (GO:0006573)3.63518776
71carnitine transport (GO:0015879)3.63411935
72amino-acid betaine transport (GO:0015838)3.63411935
73regulation of fatty acid oxidation (GO:0046320)3.62843013
74response to muscle activity (GO:0014850)3.62101323
75regulation of sulfur metabolic process (GO:0042762)3.61263314
76branched-chain amino acid metabolic process (GO:0009081)3.59309998
77muscle contraction (GO:0006936)3.53342869
78pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.52068967
79regulation of striated muscle contraction (GO:0006942)3.51560918
80fatty acid oxidation (GO:0019395)3.50284588
81fatty acid catabolic process (GO:0009062)3.49238387
82negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.46037189
83lipid oxidation (GO:0034440)3.42100811
84fructose metabolic process (GO:0006000)3.40912116
85negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.37600507
86regulation of ATP catabolic process (GO:1903289)3.36797372
87regulation of ATPase activity (GO:0043462)3.36797372
88mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.36784090
89negative regulation of striated muscle cell apoptotic process (GO:0010664)3.36758514
90cardiac muscle hypertrophy in response to stress (GO:0014898)3.36488256
91muscle hypertrophy in response to stress (GO:0003299)3.36488256
92cardiac muscle adaptation (GO:0014887)3.36488256
93hexose biosynthetic process (GO:0019319)3.34580241
94cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.33156109
95actin filament-based movement (GO:0030048)3.30783708
96carnitine metabolic process (GO:0009437)3.30650956
97purine deoxyribonucleotide catabolic process (GO:0009155)3.28151508
98skeletal muscle fiber development (GO:0048741)3.27049561
99monosaccharide biosynthetic process (GO:0046364)3.25854311
100deoxyribonucleotide catabolic process (GO:0009264)3.25324489
101regulation of sequestering of triglyceride (GO:0010889)3.23249243
102glycogen biosynthetic process (GO:0005978)3.21698434
103glucan biosynthetic process (GO:0009250)3.21698434
104ubiquinone biosynthetic process (GO:0006744)3.21355784
105quinone biosynthetic process (GO:1901663)3.21355784
106regulation of cardioblast differentiation (GO:0051890)3.18651030
107deoxyribose phosphate biosynthetic process (GO:0046385)3.16993374
1082-deoxyribonucleotide biosynthetic process (GO:0009265)3.16993374
109galactose catabolic process (GO:0019388)3.14534538
110nucleotide salvage (GO:0043173)3.12182134
1114-hydroxyproline metabolic process (GO:0019471)3.11665074
112cell communication involved in cardiac conduction (GO:0086065)3.10688721
113muscle system process (GO:0003012)3.10300888
114regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.07472651
115deoxyribose phosphate catabolic process (GO:0046386)3.01951741
116regulation of membrane repolarization (GO:0060306)3.01834392
117mucosal-associated lymphoid tissue development (GO:0048537)2.99952737
118Peyers patch development (GO:0048541)2.99952737
119quaternary ammonium group transport (GO:0015697)2.99587233
120myotube cell development (GO:0014904)2.97064233
121pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.95741105
122striated muscle cell development (GO:0055002)2.95218286
123glycogen catabolic process (GO:0005980)2.94849811
124fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.93047179
125ATP biosynthetic process (GO:0006754)2.91593948
126negative regulation of necroptotic process (GO:0060546)2.91480484
127monocarboxylic acid catabolic process (GO:0072329)2.91284867
128trabecula formation (GO:0060343)2.90003861
129short-chain fatty acid metabolic process (GO:0046459)2.89138984
130sarcoplasmic reticulum calcium ion transport (GO:0070296)2.87689305
131regulation of cell communication by electrical coupling (GO:0010649)2.87579067
132aerobic respiration (GO:0009060)2.87384158
133ubiquinone metabolic process (GO:0006743)2.84664679
134cell communication by electrical coupling (GO:0010644)2.84263060
135creatine metabolic process (GO:0006600)2.83588641
136pyrimidine nucleotide catabolic process (GO:0006244)2.80232987
137glycolytic process (GO:0006096)2.77886631
138glucan catabolic process (GO:0009251)2.75304046
139negative regulation of erythrocyte differentiation (GO:0045647)2.74178150
140negative regulation of B cell apoptotic process (GO:0002903)2.73884400
141porphyrin-containing compound biosynthetic process (GO:0006779)2.73787587
142striated muscle atrophy (GO:0014891)2.71479485
143positive regulation of myotube differentiation (GO:0010831)2.68414155
144protoporphyrinogen IX metabolic process (GO:0046501)2.66234497
145striated muscle adaptation (GO:0014888)2.63615862
146response to mercury ion (GO:0046689)2.61068260
147positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.59742387

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.41271708
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.00398954
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.89050411
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.66754328
5TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.43206363
6E2F7_22180533_ChIP-Seq_HELA_Human3.25981881
7ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.75010078
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.69938902
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.39595250
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.31028807
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.30955203
12ZNF263_19887448_ChIP-Seq_K562_Human2.13459334
13* RXR_22158963_ChIP-Seq_LIVER_Mouse2.11299878
14* TBX20_22080862_ChIP-Seq_HEART_Mouse2.11135551
15* TBX20_22328084_ChIP-Seq_HEART_Mouse2.11135551
16RARG_19884340_ChIP-ChIP_MEFs_Mouse2.06797577
17CLOCK_20551151_ChIP-Seq_293T_Human1.92570964
18MYC_18358816_ChIP-ChIP_MESCs_Mouse1.92341078
19EP300_21415370_ChIP-Seq_HL-1_Mouse1.90758236
20GATA4_21415370_ChIP-Seq_HL-1_Mouse1.90728449
21TET1_21451524_ChIP-Seq_MESCs_Mouse1.90024540
22NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.86066553
23KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.85714292
24* MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.85540316
25TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84395030
26SRY_22984422_ChIP-ChIP_TESTIS_Rat1.84259821
27STAT3_1855785_ChIP-Seq_MESCs_Mouse1.78697521
28CREB1_15753290_ChIP-ChIP_HEK293T_Human1.77381078
29GATA1_22025678_ChIP-Seq_K562_Human1.76167982
30RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71845516
31SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.71674989
32MYC_19030024_ChIP-ChIP_MESCs_Mouse1.67236430
33KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.66562153
34JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.64467680
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.63772317
36* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.61548855
37TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.59859521
38NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.59629409
39ZFX_18555785_ChIP-Seq_MESCs_Mouse1.59550318
40ELF1_20517297_ChIP-Seq_JURKAT_Human1.57638213
41NELFA_20434984_ChIP-Seq_ESCs_Mouse1.57135234
42MYC_19079543_ChIP-ChIP_MESCs_Mouse1.53515593
43ETS1_20019798_ChIP-Seq_JURKAT_Human1.52880139
44KDM2B_26808549_Chip-Seq_DND41_Human1.52812525
45CIITA_25753668_ChIP-Seq_RAJI_Human1.50966965
46BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.50770029
47VDR_21846776_ChIP-Seq_THP-1_Human1.50326732
48AR_21909140_ChIP-Seq_LNCAP_Human1.47947172
49FOXM1_23109430_ChIP-Seq_U2OS_Human1.47679698
50SA1_27219007_Chip-Seq_ERYTHROID_Human1.47478025
51MYC_22102868_ChIP-Seq_BL_Human1.47314570
52HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.46718939
53* LXR_22158963_ChIP-Seq_LIVER_Mouse1.46701004
54CTCF_26484167_Chip-Seq_Bcells_Mouse1.46670053
55KDM2B_26808549_Chip-Seq_SUP-B15_Human1.46514003
56HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.46082214
57GATA1_19941827_ChIP-Seq_MEL_Mouse1.44682595
58* VDR_24763502_ChIP-Seq_THP-1_Human1.44370360
59PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.44289786
60TCF7_22412390_ChIP-Seq_EML_Mouse1.42186257
61UTX_26944678_Chip-Seq_JUKART_Human1.41631966
62CTCF_27219007_Chip-Seq_ERYTHROID_Human1.40468980
63SMC4_20622854_ChIP-Seq_HELA_Human1.40389181
64MAF_26560356_Chip-Seq_TH1_Human1.38933120
65BCOR_27268052_Chip-Seq_Bcells_Human1.38769451
66E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.38652342
67* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.38418908
68MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.37217397
69EST1_17652178_ChIP-ChIP_JURKAT_Human1.33551876
70IRF8_22096565_ChIP-ChIP_GC-B_Human1.33244506
71PU.1_20513432_ChIP-Seq_Bcells_Mouse1.31746125
72ESR2_21235772_ChIP-Seq_MCF-7_Human1.30246123
73XRN2_22483619_ChIP-Seq_HELA_Human1.29805970
74PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29642090
75CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29562462
76CTCF_27219007_Chip-Seq_Bcells_Human1.28185830
77ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.27674750
78LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.27556137
79CTCF_21964334_ChIP-Seq_BJAB-B_Human1.26298843
80DNAJC2_21179169_ChIP-ChIP_NT2_Human1.25951489
81FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.25890780
82CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.23408872
83SA1_27219007_Chip-Seq_Bcells_Human1.23144103
84ELK3_25401928_ChIP-Seq_HUVEC_Human1.22300253
85CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.21528758
86LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.20829280
87MAF_26560356_Chip-Seq_TH2_Human1.20794317
88ERG_21242973_ChIP-ChIP_JURKAT_Human1.20550045
89GABP_17652178_ChIP-ChIP_JURKAT_Human1.20305156
90SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.19519540
91CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.19342418
92SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.18498742
93DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.17192183
94CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.15533300
95PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15051526
96DCP1A_22483619_ChIP-Seq_HELA_Human1.14789626
97E2F4_17652178_ChIP-ChIP_JURKAT_Human1.14676666
98ESR1_20079471_ChIP-ChIP_T-47D_Human1.14604966
99PHF8_20622854_ChIP-Seq_HELA_Human1.14457139
100FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.14443779
101MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.14397850
102NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.14088442
103ATF3_27146783_Chip-Seq_COLON_Human1.13375634
104PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.13291750
105NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.11818237
106CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.11369242
107NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.11055773
108ETS1_21867929_ChIP-Seq_TH2_Mouse1.10977778
109GABP_19822575_ChIP-Seq_HepG2_Human1.10521116
110ELF1_17652178_ChIP-ChIP_JURKAT_Human1.10436864
111EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.10119517
112NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.09915426
113E2F1_20622854_ChIP-Seq_HELA_Human1.09760178
114NANOG_18555785_ChIP-Seq_MESCs_Mouse1.09484898
115LXR_22292898_ChIP-Seq_THP-1_Human1.09298648
116SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.09065762
117SPI1_20517297_ChIP-Seq_HL60_Human1.08933810
118CTCF_18555785_ChIP-Seq_MESCs_Mouse1.08892164
119RARB_24833708_ChIP-Seq_LIVER_Mouse1.08248987
120ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07789339
121SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.07688759
122E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.07131745
123YY1_21170310_ChIP-Seq_MESCs_Mouse1.06021096
124TBX5_21415370_ChIP-Seq_HL-1_Mouse1.05631348
125GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05330381
126PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.04048229
127SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.03228985
128SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02800361
129THAP11_20581084_ChIP-Seq_MESCs_Mouse1.02635882
130* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02610831
131CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.02266320
132ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02088647
133FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01163843
134HIF1A_21447827_ChIP-Seq_MCF-7_Human1.00958984
135TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00218163
136KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.99449730
137KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97926947
138CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.97738233
139* RACK7_27058665_Chip-Seq_MCF-7_Human0.95752568
140FOXP3_21729870_ChIP-Seq_TREG_Human0.95010984
141RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.93191759
142RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.92428302
143ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.92251730
144YY1_22570637_ChIP-Seq_MALME-3M_Human0.92200758
145P68_20966046_ChIP-Seq_HELA_Human0.90654598
146DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.90318203
147POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.90243402
148BCL6_27268052_Chip-Seq_Bcells_Human0.88155488
149CTCF_21964334_Chip-Seq_Bcells_Human0.86777311
150HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.86516810
151SCL_19346495_ChIP-Seq_HPC-7_Human0.86322415
152SOX2_18692474_ChIP-Seq_MEFs_Mouse0.85931194
153SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.85919977
154MYCN_18555785_ChIP-Seq_MESCs_Mouse0.85441380

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle5.49810184
2MP0002837_dystrophic_cardiac_calcinosis5.42684386
3MP0003646_muscle_fatigue4.44869294
4MP0004215_abnormal_myocardial_fiber4.11843894
5MP0000751_myopathy4.04251599
6MP0005330_cardiomyopathy3.75266817
7MP0004036_abnormal_muscle_relaxation3.69515059
8MP0000749_muscle_degeneration3.17717819
9MP0002972_abnormal_cardiac_muscle2.80397743
10MP0008775_abnormal_heart_ventricle2.72418414
11MP0004087_abnormal_muscle_fiber2.71490640
12MP0010630_abnormal_cardiac_muscle2.59461132
13MP0003137_abnormal_impulse_conducting2.49295328
14MP0005385_cardiovascular_system_phenoty2.46904814
15MP0001544_abnormal_cardiovascular_syste2.46904814
16MP0000750_abnormal_muscle_regeneration2.40881478
17MP0006036_abnormal_mitochondrial_physio2.28434209
18MP0006138_congestive_heart_failure2.22922983
19MP0005620_abnormal_muscle_contractility2.22904528
20MP0003221_abnormal_cardiomyocyte_apopto2.18891674
21MP0004130_abnormal_muscle_cell2.17892955
22MP0003828_pulmonary_edema2.17690251
23MP0002269_muscular_atrophy2.11064539
24MP0002106_abnormal_muscle_physiology2.05597276
25MP0003567_abnormal_fetal_cardiomyocyte1.94550760
26MP0003806_abnormal_nucleotide_metabolis1.81781757
27MP0004484_altered_response_of1.76584090
28MP0005058_abnormal_lysosome_morphology1.75554848
29MP0005369_muscle_phenotype1.62036923
30MP0004233_abnormal_muscle_weight1.61422174
31MP0000747_muscle_weakness1.60770364
32MP0004085_abnormal_heartbeat1.59951384
33MP0005666_abnormal_adipose_tissue1.57504797
34MP0002127_abnormal_cardiovascular_syste1.55682568
35MP0000759_abnormal_skeletal_muscle1.54902988
36MP0005670_abnormal_white_adipose1.53757837
37MP0010368_abnormal_lymphatic_system1.39929272
38MP0004145_abnormal_muscle_electrophysio1.39014960
39MP0009278_abnormal_bone_marrow1.30622590
40MP0003656_abnormal_erythrocyte_physiolo1.26774082
41MP0003279_aneurysm1.24739848
42MP0001727_abnormal_embryo_implantation1.23385203
43MP0003705_abnormal_hypodermis_morpholog1.20703755
44MP0000266_abnormal_heart_morphology1.20381905
45MP0002822_catalepsy1.18671390
46MP0000343_altered_response_to1.16977065
47MP0006035_abnormal_mitochondrial_morpho1.16744369
48MP0004043_abnormal_pH_regulation1.13327686
49MP0005332_abnormal_amino_acid1.08342029
50MP0003566_abnormal_cell_adhesion1.05155885
51MP0005165_increased_susceptibility_to1.04757075
52MP0005397_hematopoietic_system_phenotyp1.03250536
53MP0001545_abnormal_hematopoietic_system1.03250536
54MP0005085_abnormal_gallbladder_physiolo1.02740535
55MP0005319_abnormal_enzyme/_coenzyme1.01843081
56MP0005266_abnormal_metabolism1.00344859
57MP0005365_abnormal_bile_salt0.99633407
58MP0002332_abnormal_exercise_endurance0.98176214
59MP0005360_urolithiasis0.98066562
60MP0002234_abnormal_pharynx_morphology0.97759993
61MP0004858_abnormal_nervous_system0.97215057
62MP0004272_abnormal_basement_membrane0.96989077
63MP0009840_abnormal_foam_cell0.95363049
64MP0005375_adipose_tissue_phenotype0.94575388
65MP0001661_extended_life_span0.93822312
66MP0009643_abnormal_urine_homeostasis0.92166737
67MP0005645_abnormal_hypothalamus_physiol0.86007246
68MP0003186_abnormal_redox_activity0.85087641
69MP0002128_abnormal_blood_circulation0.85002143
70MP0006054_spinal_hemorrhage0.84008079
71MP0003950_abnormal_plasma_membrane0.83849597
72MP0005083_abnormal_biliary_tract0.82820436
73MP0002139_abnormal_hepatobiliary_system0.82528750
74MP0004185_abnormal_adipocyte_glucose0.82079435
75MP0008260_abnormal_autophagy0.80457025
76MP0005451_abnormal_body_composition0.80144069
77MP0003984_embryonic_growth_retardation0.79689650
78MP0002088_abnormal_embryonic_growth/wei0.78468930
79MP0004510_myositis0.78340136
80MP0000230_abnormal_systemic_arterial0.77999217
81MP0002166_altered_tumor_susceptibility0.77433658
82MP0002653_abnormal_ependyma_morphology0.74885176
83MP0008438_abnormal_cutaneous_collagen0.74635640
84MP0001879_abnormal_lymphatic_vessel0.74203557
85MP0003195_calcinosis0.73909697
86MP0000465_gastrointestinal_hemorrhage0.73679019
87MP0005025_abnormal_response_to0.73550352
88MP0003252_abnormal_bile_duct0.70926627
89MP0003763_abnormal_thymus_physiology0.66628487
90MP0005464_abnormal_platelet_physiology0.66004492
91MP0002396_abnormal_hematopoietic_system0.65546946
92MP0009697_abnormal_copulation0.64885384
93MP0005166_decreased_susceptibility_to0.63842506
94MP0000013_abnormal_adipose_tissue0.62433512
95MP0002078_abnormal_glucose_homeostasis0.62336548
96MP0001672_abnormal_embryogenesis/_devel0.60964500
97MP0005380_embryogenesis_phenotype0.60964500
98MP0002971_abnormal_brown_adipose0.60395482
99MP0005584_abnormal_enzyme/coenzyme_acti0.58764365
100MP0000767_abnormal_smooth_muscle0.57915739
101MP0004147_increased_porphyrin_level0.57626084
102MP0001853_heart_inflammation0.57543905
103MP0000733_abnormal_muscle_development0.55075845
104MP0003123_paternal_imprinting0.54781635
105MP0009384_cardiac_valve_regurgitation0.54781306
106MP0005334_abnormal_fat_pad0.54542101
107MP0003191_abnormal_cellular_cholesterol0.54137169
108MP0002118_abnormal_lipid_homeostasis0.53657768
109MP0002108_abnormal_muscle_morphology0.53096847
110MP0001756_abnormal_urination0.52950286
111MP0005535_abnormal_body_temperature0.52807582
112MP0001666_abnormal_nutrient_absorption0.52604229
113MP0003075_altered_response_to0.51714879
114MP0003878_abnormal_ear_physiology0.51310726
115MP0005377_hearing/vestibular/ear_phenot0.51310726
116MP0002877_abnormal_melanocyte_morpholog0.51273356
117MP0000681_abnormal_thyroid_gland0.51181195
118MP0002925_abnormal_cardiovascular_devel0.51052348
119MP0000358_abnormal_cell_content/0.50969657
120MP0000685_abnormal_immune_system0.50547568
121MP0001730_embryonic_growth_arrest0.49962530
122MP0000609_abnormal_liver_physiology0.49703542
123MP0003948_abnormal_gas_homeostasis0.48717572
124MP0008874_decreased_physiological_sensi0.47838686
125MP0000003_abnormal_adipose_tissue0.47726356
126MP0001614_abnormal_blood_vessel0.47661381
127MP0005376_homeostasis/metabolism_phenot0.46822698
128MP0001697_abnormal_embryo_size0.46491803
129MP0003879_abnormal_hair_cell0.46440804
130MP0002970_abnormal_white_adipose0.46240047
131MP0000372_irregular_coat_pigmentation0.46122979
132MP0009764_decreased_sensitivity_to0.45501710
133MP0001764_abnormal_homeostasis0.45461423
134MP0009115_abnormal_fat_cell0.44398964
135MP0003866_abnormal_defecation0.44092878
136MP0001873_stomach_inflammation0.43842068
137MP0008469_abnormal_protein_level0.42318713

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)8.00620230
2Nemaline bodies (HP:0003798)7.90532022
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)7.74941136
4Sudden death (HP:0001699)6.61759081
5Ventricular tachycardia (HP:0004756)6.02298190
6Myopathic facies (HP:0002058)5.34771273
7Centrally nucleated skeletal muscle fibers (HP:0003687)5.23975402
8Myoglobinuria (HP:0002913)5.10337627
9Exercise-induced muscle cramps (HP:0003710)5.02618881
10Lipoatrophy (HP:0100578)4.89581086
11Atrial fibrillation (HP:0005110)4.85498385
12Subaortic stenosis (HP:0001682)4.79091633
13Abnormality of the left ventricular outflow tract (HP:0011103)4.79091633
14Calf muscle hypertrophy (HP:0008981)4.60514530
15Primary atrial arrhythmia (HP:0001692)4.51272198
16Supraventricular tachycardia (HP:0004755)4.47098112
17Palpitations (HP:0001962)4.42115202
18Supraventricular arrhythmia (HP:0005115)4.40776743
19Exercise-induced myalgia (HP:0003738)4.37917168
20Hypoglycemic coma (HP:0001325)4.30003241
21Distal arthrogryposis (HP:0005684)4.15742345
22Dilated cardiomyopathy (HP:0001644)4.14961966
23Right ventricular cardiomyopathy (HP:0011663)4.11838344
24Rhabdomyolysis (HP:0003201)4.11730004
25Muscle fiber splitting (HP:0003555)4.10614010
26Abnormality of the calf musculature (HP:0001430)4.05543832
27Muscle hypertrophy of the lower extremities (HP:0008968)4.04081781
28Hepatic necrosis (HP:0002605)3.97175866
29Asymmetric septal hypertrophy (HP:0001670)3.94647771
30Ketoacidosis (HP:0001993)3.93074402
31Abnormality of skeletal muscle fiber size (HP:0012084)3.89208360
32Abnormality of fatty-acid metabolism (HP:0004359)3.75205443
33Ulnar deviation of the wrist (HP:0003049)3.72712479
34Rimmed vacuoles (HP:0003805)3.69141267
35Syncope (HP:0001279)3.67325705
36Round ear (HP:0100830)3.53622970
37Ventricular arrhythmia (HP:0004308)3.50966656
38Generalized aminoaciduria (HP:0002909)3.45837981
39Ragged-red muscle fibers (HP:0003200)3.38684210
40Prolonged QT interval (HP:0001657)3.26560370
41* Dicarboxylic aciduria (HP:0003215)3.26362712
42* Abnormality of dicarboxylic acid metabolism (HP:0010995)3.26362712
43Hyporeflexia of lower limbs (HP:0002600)3.25196545
44Increased variability in muscle fiber diameter (HP:0003557)3.23145632
45Ketosis (HP:0001946)3.21398407
46Bundle branch block (HP:0011710)3.18384906
47Hepatocellular necrosis (HP:0001404)3.15432283
48Increased connective tissue (HP:0009025)3.14610779
49Abnormal mitochondria in muscle tissue (HP:0008316)3.12434600
50EMG: neuropathic changes (HP:0003445)3.12416299
51EMG: myopathic abnormalities (HP:0003458)3.09999788
52Atrioventricular block (HP:0001678)3.06898602
53Calcaneovalgus deformity (HP:0001848)3.01492101
54Hyperglycinuria (HP:0003108)2.92757721
55Heart block (HP:0012722)2.91825938
56Increased muscle lipid content (HP:0009058)2.89844733
57Acute necrotizing encephalopathy (HP:0006965)2.89238828
58Bulbar palsy (HP:0001283)2.86749459
59Distal lower limb amyotrophy (HP:0008944)2.86345521
60Acute encephalopathy (HP:0006846)2.84186990
61Ventricular fibrillation (HP:0001663)2.81327554
62Areflexia of lower limbs (HP:0002522)2.79817527
63Cerebral edema (HP:0002181)2.79204591
64Conjunctival hamartoma (HP:0100780)2.75911434
65Hyperammonemia (HP:0001987)2.74511568
66Abnormal atrioventricular conduction (HP:0005150)2.73770137
67Mildly elevated creatine phosphokinase (HP:0008180)2.68174567
68Deformed tarsal bones (HP:0008119)2.63177966
69Increased CSF lactate (HP:0002490)2.59293371
70Lactic acidosis (HP:0003128)2.58983723
71Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.58481798
72Mitochondrial inheritance (HP:0001427)2.53386125
73Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.46751759
74Abnormality of alanine metabolism (HP:0010916)2.46751759
75Hyperalaninemia (HP:0003348)2.46751759
76Abnormality of glycine metabolism (HP:0010895)2.46532697
77Abnormality of serine family amino acid metabolism (HP:0010894)2.46532697
78Increased intramyocellular lipid droplets (HP:0012240)2.44237610
79Myotonia (HP:0002486)2.44022272
80Proximal tubulopathy (HP:0000114)2.42048309
81Type 1 muscle fiber predominance (HP:0003803)2.40861726
82Nausea (HP:0002018)2.38042883
83Progressive muscle weakness (HP:0003323)2.37735139
84Esophageal neoplasm (HP:0100751)2.37117750
85Neoplasm of head and neck (HP:0012288)2.37117750
86Exercise intolerance (HP:0003546)2.35414206
87Decreased activity of mitochondrial respiratory chain (HP:0008972)2.34516874
88Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.34516874
89Malignant hyperthermia (HP:0002047)2.32034793
90Palmoplantar keratoderma (HP:0000982)2.30256455
91Abnormal EKG (HP:0003115)2.27469255
92Hyperinsulinemic hypoglycemia (HP:0000825)2.27173947
93Scapular winging (HP:0003691)2.27084606
94* Cerebral palsy (HP:0100021)2.25215055
95Progressive macrocephaly (HP:0004481)2.24568374
96Late onset (HP:0003584)2.22190405
97Left ventricular hypertrophy (HP:0001712)2.21944412
98Difficulty running (HP:0009046)2.21744089
99Absent phalangeal crease (HP:0006109)2.21009822
100Reticulocytosis (HP:0001923)2.20095769
101Respiratory failure (HP:0002878)2.19610032
102Increased serum pyruvate (HP:0003542)2.18542850
103Abnormality of glycolysis (HP:0004366)2.18542850
104Difficulty climbing stairs (HP:0003551)2.15317110
105Limb-girdle muscle atrophy (HP:0003797)2.14874865
106Abnormality of the foot musculature (HP:0001436)2.12457290
107Agammaglobulinemia (HP:0004432)2.08679509
108Neonatal death (HP:0003811)2.07429272
109Generalized muscle weakness (HP:0003324)2.07006401
110Pancreatic islet-cell hyperplasia (HP:0004510)2.06786051
111Metabolic acidosis (HP:0001942)2.06769187
112Muscle stiffness (HP:0003552)2.05270739
113Cholelithiasis (HP:0001081)2.04867679
114Gout (HP:0001997)2.03757866
115Increased serum lactate (HP:0002151)2.00987640
116Lethargy (HP:0001254)2.00806163
117Foot dorsiflexor weakness (HP:0009027)1.99639503
118Frequent falls (HP:0002359)1.99600457
119Abnormal gallbladder physiology (HP:0012438)1.98886830
120Cholecystitis (HP:0001082)1.98886830
121Weak cry (HP:0001612)1.97697160
122Distal lower limb muscle weakness (HP:0009053)1.97520396
123Neck muscle weakness (HP:0000467)1.92009425
124Oligomenorrhea (HP:0000876)1.90309325
125Lipid accumulation in hepatocytes (HP:0006561)1.89923600
126Abnormality of the calcaneus (HP:0008364)1.87668561
127Gowers sign (HP:0003391)1.86179374
128Sudden cardiac death (HP:0001645)1.85369749
129Large for gestational age (HP:0001520)1.84763103
130Congestive heart failure (HP:0001635)1.84372875
131Hamartoma of the eye (HP:0010568)1.84009901
132Pheochromocytoma (HP:0002666)1.83859358
133Paralysis (HP:0003470)1.82267009
134Waddling gait (HP:0002515)1.82207070
135Glycosuria (HP:0003076)1.79884456
136Abnormality of urine glucose concentration (HP:0011016)1.79884456
137Lower limb amyotrophy (HP:0007210)1.79538107
138Diaphragmatic weakness (HP:0009113)1.69319490
139Systemic lupus erythematosus (HP:0002725)1.66724373
140Abnormal gallbladder morphology (HP:0012437)1.66385858
141Abnormality of the tricuspid valve (HP:0001702)1.65673859
142Muscle fiber atrophy (HP:0100295)1.65468934
143Abnormal finger flexion creases (HP:0006143)1.61737138
144Microvesicular hepatic steatosis (HP:0001414)1.61275188
145Fetal akinesia sequence (HP:0001989)1.57867061

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PKN24.54096469
2TTN4.42842547
3BCKDK4.12923515
4TRIB33.83226592
5TESK23.49595195
6OBSCN3.41715615
7MYLK3.27462094
8LMTK23.23580859
9NEK13.06351525
10PDK32.99662714
11PDK42.99662714
12FLT32.96123311
13TESK12.73151572
14PHKG12.37972641
15PHKG22.37972641
16TIE12.25685467
17VRK22.00181073
18DMPK1.76429199
19STK241.71276461
20LIMK11.64096699
21NME21.61023714
22ILK1.57179812
23MAPKAPK31.53086336
24PDK21.51481747
25MAP2K31.49327286
26PIM21.40000953
27KDR1.37555586
28WNK41.31759805
29SMG11.31515658
30PIK3CA1.29897275
31PINK11.18379214
32MUSK1.16648973
33EEF2K1.15027949
34ERN11.15001088
35TGFBR11.14172273
36WEE11.12287302
37PRPF4B1.11301789
38MAP3K101.07976085
39LRRK21.07014022
40MAP4K11.05805703
41STK41.01192566
42TGFBR20.98556705
43TNK20.98449214
44RIPK10.92047201
45NME10.91475256
46MAP3K30.90085403
47INSRR0.89079374
48ZAK0.87953674
49ARAF0.87609124
50ICK0.87500926
51STK38L0.85441522
52RPS6KB20.84306114
53CAMK2G0.83991289
54SIK10.83682226
55PDGFRA0.82763775
56PRKD10.82626733
57PTK60.80972757
58PASK0.76365424
59CCNB10.73934906
60MAP3K70.73356551
61MAPK40.72109589
62SCYL20.69934102
63PAK40.69453317
64NEK90.69368313
65TAOK10.67301820
66MAP3K130.65268951
67MAP3K50.63466775
68PRKAA20.62594269
69TRPM70.62374234
70CDC42BPA0.61433590
71PRKAA10.61184419
72CDK40.60959858
73MAPK120.60664315
74AKT20.59937762
75DAPK30.59726036
76PAK30.58872222
77ROCK10.57897677
78MAP2K40.56602818
79MAPK110.56425229
80CAMK40.54507557
81DAPK10.54451721
82MAP2K20.53489656
83KIT0.52707161
84AURKA0.51982348
85MAP3K10.50821180
86RPS6KA20.49153575
87CAMK2D0.48678247
88BRSK20.48599858
89EPHA30.48485887
90AURKB0.48077301
91RPS6KL10.47937513
92RPS6KC10.47937513
93ABL20.47760063
94STK160.46746906
95TYK20.46653750
96MAP3K110.46423257
97MAP3K80.45070657
98SYK0.44156755
99RPS6KA60.42269004
100GRK70.41877695
101BUB10.40935638
102FGFR40.39232985
103CAMK2B0.38901502
104GRK60.38620535
105PRKG20.36557467
106DYRK30.36302154
107RPS6KA40.35124819
108IKBKE0.34856763
109EIF2AK30.34740640
110ACVR1B0.34610993
111PAK20.32942011
112BTK0.32338508
113NEK20.32336765
114RPS6KA10.32295498
115PIK3CG0.31631977
116MTOR0.31291412
117TAOK20.31204430
118EPHA20.30723194
119MARK20.30187637
120CAMK10.29570394
121RPS6KA50.29545138
122BLK0.29432636
123VRK10.29143911
124TTK0.28481896
125CDK80.28432467
126WNK30.28351071
127PRKACB0.27860911
128MAP2K10.27726602
129MAPK70.26631135
130PDPK10.26051181
131CDK70.25448053
132MAPK30.25321173
133MATK0.25203458
134RET0.24277230
135RAF10.24113955
136ZAP700.23972986
137TBK10.22388673
138DYRK1B0.22192833
139PRKACG0.21928826
140CSF1R0.20389690
141MAP2K60.20342352
142STK100.20152452
143CDC70.19947467
144TEC0.19410927

Predicted pathways (KEGG)

RankGene SetZ-score
1* Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.74708293
2* 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.04705670
3Propanoate metabolism_Homo sapiens_hsa006403.56864508
4Fatty acid degradation_Homo sapiens_hsa000713.49517084
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.10611077
6* Carbon metabolism_Homo sapiens_hsa012002.85713999
7Cardiac muscle contraction_Homo sapiens_hsa042602.70414804
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.63821067
9Parkinsons disease_Homo sapiens_hsa050122.52924750
10Fatty acid metabolism_Homo sapiens_hsa012122.47849447
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.45207676
12Oxidative phosphorylation_Homo sapiens_hsa001902.26736026
13Pyruvate metabolism_Homo sapiens_hsa006202.13294319
14Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.11658918
15Dilated cardiomyopathy_Homo sapiens_hsa054142.08770194
16* Biosynthesis of amino acids_Homo sapiens_hsa012301.78955028
17Butanoate metabolism_Homo sapiens_hsa006501.78028602
18Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.72464442
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.69130932
20Alzheimers disease_Homo sapiens_hsa050101.53865804
21Huntingtons disease_Homo sapiens_hsa050161.52904979
22Tryptophan metabolism_Homo sapiens_hsa003801.51492359
23DNA replication_Homo sapiens_hsa030301.47337980
24Primary immunodeficiency_Homo sapiens_hsa053401.44650287
25Fatty acid elongation_Homo sapiens_hsa000621.37019216
26Starch and sucrose metabolism_Homo sapiens_hsa005001.31097404
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.26284605
28beta-Alanine metabolism_Homo sapiens_hsa004101.24805621
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.24413232
30PPAR signaling pathway_Homo sapiens_hsa033201.24262892
31Galactose metabolism_Homo sapiens_hsa000521.19700951
32Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.18980406
33Lysine degradation_Homo sapiens_hsa003101.08437396
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.02323622
35Arginine and proline metabolism_Homo sapiens_hsa003301.01886258
36* Peroxisome_Homo sapiens_hsa041461.01217919
37Viral myocarditis_Homo sapiens_hsa054161.00579199
38Ribosome_Homo sapiens_hsa030101.00360498
39Pentose phosphate pathway_Homo sapiens_hsa000300.99413561
40Selenocompound metabolism_Homo sapiens_hsa004500.98871678
41Mismatch repair_Homo sapiens_hsa034300.98507443
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93616140
43Arginine biosynthesis_Homo sapiens_hsa002200.93441264
44Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.91314989
45Fructose and mannose metabolism_Homo sapiens_hsa000510.88302921
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.85968654
47Insulin resistance_Homo sapiens_hsa049310.85097578
48Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74945357
49Base excision repair_Homo sapiens_hsa034100.74082793
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.73914927
51One carbon pool by folate_Homo sapiens_hsa006700.73217961
52Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.71260582
53Glycosaminoglycan degradation_Homo sapiens_hsa005310.70935526
54Glucagon signaling pathway_Homo sapiens_hsa049220.69095113
55Phenylalanine metabolism_Homo sapiens_hsa003600.68139677
56Folate biosynthesis_Homo sapiens_hsa007900.67210751
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66235219
58Adipocytokine signaling pathway_Homo sapiens_hsa049200.66171661
59Sulfur relay system_Homo sapiens_hsa041220.64750046
60Systemic lupus erythematosus_Homo sapiens_hsa053220.62952822
61Central carbon metabolism in cancer_Homo sapiens_hsa052300.61963313
62Acute myeloid leukemia_Homo sapiens_hsa052210.58678902
63Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.58217743
64Insulin signaling pathway_Homo sapiens_hsa049100.56589535
65* Metabolic pathways_Homo sapiens_hsa011000.56221353
66AMPK signaling pathway_Homo sapiens_hsa041520.53344902
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52510362
68Fat digestion and absorption_Homo sapiens_hsa049750.50554819
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.50491216
70Pyrimidine metabolism_Homo sapiens_hsa002400.50463223
71HIF-1 signaling pathway_Homo sapiens_hsa040660.50133644
72Asthma_Homo sapiens_hsa053100.49892979
73Drug metabolism - other enzymes_Homo sapiens_hsa009830.48982757
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.46560323
75Sulfur metabolism_Homo sapiens_hsa009200.46114850
76Proteasome_Homo sapiens_hsa030500.46002014
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44091198
78Renin-angiotensin system_Homo sapiens_hsa046140.40221312
79Tyrosine metabolism_Homo sapiens_hsa003500.39903425
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.38797659
81Calcium signaling pathway_Homo sapiens_hsa040200.37012321
82Histidine metabolism_Homo sapiens_hsa003400.36507081
83Oxytocin signaling pathway_Homo sapiens_hsa049210.34976233
84Focal adhesion_Homo sapiens_hsa045100.34681654
85Intestinal immune network for IgA production_Homo sapiens_hsa046720.34579702
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32820095
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32236722
88Homologous recombination_Homo sapiens_hsa034400.31557328
89* Glutathione metabolism_Homo sapiens_hsa004800.31011474
90Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.30611142
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29480434
92Staphylococcus aureus infection_Homo sapiens_hsa051500.28897371
93Nucleotide excision repair_Homo sapiens_hsa034200.27457519
94Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.27291113
95Small cell lung cancer_Homo sapiens_hsa052220.26763068
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26671286
97Antigen processing and presentation_Homo sapiens_hsa046120.24852724
98Fatty acid biosynthesis_Homo sapiens_hsa000610.24538227
99Spliceosome_Homo sapiens_hsa030400.23297428
100Purine metabolism_Homo sapiens_hsa002300.21700554
101Glycerolipid metabolism_Homo sapiens_hsa005610.21311306
102Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.20835388
103Protein digestion and absorption_Homo sapiens_hsa049740.20344470
104cGMP-PKG signaling pathway_Homo sapiens_hsa040220.19581025
105Nitrogen metabolism_Homo sapiens_hsa009100.19485620
106RNA transport_Homo sapiens_hsa030130.19068014
107ECM-receptor interaction_Homo sapiens_hsa045120.17894759
108RNA degradation_Homo sapiens_hsa030180.17801995
109Bile secretion_Homo sapiens_hsa049760.17525805
110Carbohydrate digestion and absorption_Homo sapiens_hsa049730.16336803
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.15323348
112Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.14577531
113Bladder cancer_Homo sapiens_hsa052190.14517872
114Cell cycle_Homo sapiens_hsa041100.14493194
115Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.14378409
116Pertussis_Homo sapiens_hsa051330.14097022
117N-Glycan biosynthesis_Homo sapiens_hsa005100.13914930
118Shigellosis_Homo sapiens_hsa051310.13569087
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.13503478
120Caffeine metabolism_Homo sapiens_hsa002320.13318890
121Other glycan degradation_Homo sapiens_hsa005110.12799318
122Allograft rejection_Homo sapiens_hsa053300.12219995
123B cell receptor signaling pathway_Homo sapiens_hsa046620.12214341
124Non-small cell lung cancer_Homo sapiens_hsa052230.11973371
125Platelet activation_Homo sapiens_hsa046110.10878376
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.10717655
127Thyroid hormone signaling pathway_Homo sapiens_hsa049190.10334279

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »