IDH3A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the alpha subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* tricarboxylic acid cycle (GO:0006099)8.54666321
2NADH metabolic process (GO:0006734)7.62465847
3regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)7.13439939
4regulation of acyl-CoA biosynthetic process (GO:0050812)6.80439458
5regulation of cofactor metabolic process (GO:0051193)6.52336106
6regulation of coenzyme metabolic process (GO:0051196)6.52336106
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.92451693
8succinate metabolic process (GO:0006105)5.73448716
9oxidative phosphorylation (GO:0006119)5.50520060
10energy coupled proton transport, down electrochemical gradient (GO:0015985)5.23980048
11ATP synthesis coupled proton transport (GO:0015986)5.23980048
12respiratory electron transport chain (GO:0022904)5.23080429
13oxaloacetate metabolic process (GO:0006107)5.16600121
14mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.14790438
15electron transport chain (GO:0022900)5.11708659
16regulation of sulfur metabolic process (GO:0042762)4.87862736
17cardiac myofibril assembly (GO:0055003)4.71568870
18actin-myosin filament sliding (GO:0033275)4.65285670
19muscle filament sliding (GO:0030049)4.65285670
20regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.62173721
21sarcomere organization (GO:0045214)4.61214281
22positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.58354614
23cardiac muscle contraction (GO:0060048)4.19202926
24myofibril assembly (GO:0030239)4.13755238
25carnitine shuttle (GO:0006853)4.12355816
26regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.12124878
27negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.11329767
28regulation of cell communication by electrical coupling (GO:0010649)4.10994255
29regulation of relaxation of muscle (GO:1901077)3.97958661
30proteasome assembly (GO:0043248)3.94292959
31regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.92443438
32regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.84125417
33actin-mediated cell contraction (GO:0070252)3.71321310
34synaptic vesicle docking involved in exocytosis (GO:0016081)3.69305121
35cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.68445994
36ribosome assembly (GO:0042255)3.66226729
37membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.64495141
38striated muscle contraction (GO:0006941)3.64101696
39negative regulation of potassium ion transmembrane transport (GO:1901380)3.63943226
40regulation of sarcomere organization (GO:0060297)3.59723179
41ATP biosynthetic process (GO:0006754)3.58924077
42inner mitochondrial membrane organization (GO:0007007)3.58145463
43regulation of skeletal muscle contraction (GO:0014819)3.57850209
44respiratory chain complex IV assembly (GO:0008535)3.55433307
45aerobic respiration (GO:0009060)3.54566839
46ATP hydrolysis coupled proton transport (GO:0015991)3.53199299
47energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.53199299
48L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.52973577
49detection of calcium ion (GO:0005513)3.52948951
50cardiac muscle hypertrophy (GO:0003300)3.51122736
51regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.49604772
52gluconeogenesis (GO:0006094)3.48552268
53regulation of actin filament-based movement (GO:1903115)3.45331291
54fatty acid transmembrane transport (GO:1902001)3.43753059
55ubiquinone biosynthetic process (GO:0006744)3.39847089
56quinone biosynthetic process (GO:1901663)3.39847089
57regulation of cellular respiration (GO:0043457)3.38666369
58sarcoplasmic reticulum calcium ion transport (GO:0070296)3.38038108
59melanin biosynthetic process (GO:0042438)3.36697409
60striated muscle hypertrophy (GO:0014897)3.35780387
61regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.32681004
62regulation of membrane repolarization (GO:0060306)3.30348007
63protein complex biogenesis (GO:0070271)3.27710261
64regulation of sequestering of triglyceride (GO:0010889)3.27687667
65hexose biosynthetic process (GO:0019319)3.20535079
66mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.19763310
67mitochondrial respiratory chain complex I assembly (GO:0032981)3.19763310
68NADH dehydrogenase complex assembly (GO:0010257)3.19763310
69heart process (GO:0003015)3.19625237
70heart contraction (GO:0060047)3.19625237
71cell communication by electrical coupling (GO:0010644)3.19136909
72regulation of cellular amino acid metabolic process (GO:0006521)3.18443678
73synaptic vesicle exocytosis (GO:0016079)3.15720609
74aspartate family amino acid catabolic process (GO:0009068)3.12963228
75melanin metabolic process (GO:0006582)3.12348879
76positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.11964558
77mitochondrial respiratory chain complex assembly (GO:0033108)3.10731940
78negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.08942527
79cullin deneddylation (GO:0010388)3.08480568
80actomyosin structure organization (GO:0031032)3.08421297
81glycolytic process (GO:0006096)3.08356403
82regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.07710072
83cellular respiration (GO:0045333)3.06999331
84plasma membrane repair (GO:0001778)3.06950107
85cardiac muscle cell development (GO:0055013)3.04527211
86nucleobase-containing small molecule interconversion (GO:0015949)3.02455104
87pyruvate metabolic process (GO:0006090)3.01937180
88regulation of cardiac muscle cell contraction (GO:0086004)3.01761247
89lipid particle organization (GO:0034389)3.00158884
902-oxoglutarate metabolic process (GO:0006103)2.99796276
91carnitine transmembrane transport (GO:1902603)2.99195289
92mitochondrial genome maintenance (GO:0000002)2.99060448
93purine nucleoside monophosphate biosynthetic process (GO:0009127)2.99032640
94purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.99032640
95ketone body metabolic process (GO:1902224)2.98796478
96cardiac muscle cell action potential involved in contraction (GO:0086002)2.98470020
97ubiquinone metabolic process (GO:0006743)2.98041594
98purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.97663199
99anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.97524563
100cardiac muscle cell action potential (GO:0086001)2.97365003
101regulation of striated muscle contraction (GO:0006942)2.96861300
102lysine metabolic process (GO:0006553)2.96699091
103lysine catabolic process (GO:0006554)2.96699091
104deoxyribonucleotide biosynthetic process (GO:0009263)2.95688656
105purine nucleoside triphosphate biosynthetic process (GO:0009145)2.95028475
106muscle hypertrophy (GO:0014896)2.92639273
107glutamate secretion (GO:0014047)2.90391451
108hydrogen ion transmembrane transport (GO:1902600)2.89837698
109negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.89161312
110cardiac conduction (GO:0061337)2.88584782
111regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.88492526
112regulation of fatty acid oxidation (GO:0046320)2.87810738
113neuronal action potential propagation (GO:0019227)2.86703695
114generation of precursor metabolites and energy (GO:0006091)2.85404758
115regulation of the force of heart contraction (GO:0002026)2.85342454
116regulation of oxidative phosphorylation (GO:0002082)2.85246891
117protein K6-linked ubiquitination (GO:0085020)2.83403333
118DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.83351237
119cell communication involved in cardiac conduction (GO:0086065)2.82901905
120cardiac muscle adaptation (GO:0014887)2.82358547
121muscle hypertrophy in response to stress (GO:0003299)2.82358547
122intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.80641710
123signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.80641710
124methionine biosynthetic process (GO:0009086)2.80619536
125signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.80195191
126signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.80195191
127signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.80195191
128lactate metabolic process (GO:0006089)2.79915232
129regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.79590517
130signal peptide processing (GO:0006465)2.78655446
131amino acid salvage (GO:0043102)2.78076153
132L-methionine salvage (GO:0071267)2.78076153
133L-methionine biosynthetic process (GO:0071265)2.78076153
134cytochrome complex assembly (GO:0017004)2.77953618
135negative regulation of ligase activity (GO:0051352)2.77584917
136negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.77584917
137protein deneddylation (GO:0000338)2.76250038
138pteridine-containing compound biosynthetic process (GO:0042559)2.76230201
139signal transduction involved in DNA integrity checkpoint (GO:0072401)2.76056604
140signal transduction involved in DNA damage checkpoint (GO:0072422)2.76056604
141positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.73014906
142regulation of mitochondrial translation (GO:0070129)2.69483642
143sodium ion export (GO:0071436)2.68527928
144signal transduction involved in cell cycle checkpoint (GO:0072395)2.67346569
145positive regulation of ligase activity (GO:0051351)2.66260230
146aspartate family amino acid biosynthetic process (GO:0009067)2.63259029
147transcription from mitochondrial promoter (GO:0006390)2.60289066
148cellular ketone body metabolic process (GO:0046950)2.59581989
149relaxation of cardiac muscle (GO:0055119)2.58746817
150branched-chain amino acid catabolic process (GO:0009083)2.58465992
151secondary metabolite biosynthetic process (GO:0044550)2.54673475
152positive regulation of actin filament depolymerization (GO:0030836)2.54317474
153tRNA aminoacylation (GO:0043039)2.53589971
154amino acid activation (GO:0043038)2.53589971
155tRNA aminoacylation for protein translation (GO:0006418)2.50418402
156regulation of cellular amine metabolic process (GO:0033238)2.48002975

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.97235654
2* ESRRB_18555785_ChIP-Seq_MESCs_Mouse5.66956987
3E2F7_22180533_ChIP-Seq_HELA_Human4.37021417
4EZH2_22144423_ChIP-Seq_EOC_Human3.95061764
5TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.23979093
6GBX2_23144817_ChIP-Seq_PC3_Human3.23860439
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.09044698
8THAP11_20581084_ChIP-Seq_MESCs_Mouse2.56444985
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.55753092
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.53588695
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.53028627
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.44846645
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.34746382
14EP300_21415370_ChIP-Seq_HL-1_Mouse2.24128054
15PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.17470830
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.15784177
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.12554212
18AR_21909140_ChIP-Seq_LNCAP_Human2.09736289
19ELK1_19687146_ChIP-ChIP_HELA_Human2.05216742
20RARB_27405468_Chip-Seq_BRAIN_Mouse2.03124669
21REST_18959480_ChIP-ChIP_MESCs_Mouse1.97888902
22FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.97350914
23VDR_23849224_ChIP-Seq_CD4+_Human1.97128345
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.95645762
25SRF_21415370_ChIP-Seq_HL-1_Mouse1.95390476
26PADI4_21655091_ChIP-ChIP_MCF-7_Human1.87400559
27ETS1_20019798_ChIP-Seq_JURKAT_Human1.86320027
28EST1_17652178_ChIP-ChIP_JURKAT_Human1.83298235
29YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.81607211
30SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.79306756
31TAF15_26573619_Chip-Seq_HEK293_Human1.76831683
32PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.70419291
33YY1_21170310_ChIP-Seq_MESCs_Mouse1.69682613
34FOXP3_21729870_ChIP-Seq_TREG_Human1.69123893
35* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.69028709
36REST_21632747_ChIP-Seq_MESCs_Mouse1.68300468
37SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.67520039
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.65051357
39GATA4_21415370_ChIP-Seq_HL-1_Mouse1.62388226
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61726930
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.54525115
42HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.48766021
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.47934334
44FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.47871925
45TFEB_21752829_ChIP-Seq_HELA_Human1.46102433
46FUS_26573619_Chip-Seq_HEK293_Human1.46031736
47NELFA_20434984_ChIP-Seq_ESCs_Mouse1.45096953
48GABP_17652178_ChIP-ChIP_JURKAT_Human1.44916670
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44448686
50MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.43671649
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41654929
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41276825
53BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.41063415
54RBPJ_22232070_ChIP-Seq_NCS_Mouse1.40496339
55FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.38708581
56CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.36720360
57MYCN_18555785_ChIP-Seq_MESCs_Mouse1.36172601
58ZNF274_21170338_ChIP-Seq_K562_Hela1.35018803
59RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.34137078
60SMAD4_21799915_ChIP-Seq_A2780_Human1.33038697
61BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.31789181
62* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30058259
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.29936384
64NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.29389584
65POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26652380
66MYC_19079543_ChIP-ChIP_MESCs_Mouse1.26565541
67SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.24700744
68SOX2_21211035_ChIP-Seq_LN229_Gbm1.24568186
69SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.24263714
70MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.23349048
71PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.22853162
72MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22513970
73VDR_22108803_ChIP-Seq_LS180_Human1.21354723
74MYC_18358816_ChIP-ChIP_MESCs_Mouse1.20875174
75HTT_18923047_ChIP-ChIP_STHdh_Human1.20221469
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19256096
77RNF2_18974828_ChIP-Seq_MESCs_Mouse1.17133336
78EZH2_18974828_ChIP-Seq_MESCs_Mouse1.17133336
79PCGF2_27294783_Chip-Seq_ESCs_Mouse1.16027040
80CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.14249655
81JARID2_20064375_ChIP-Seq_MESCs_Mouse1.12888946
82TBX20_22080862_ChIP-Seq_HEART_Mouse1.11338376
83TBX20_22328084_ChIP-Seq_HEART_Mouse1.11338376
84ER_23166858_ChIP-Seq_MCF-7_Human1.09759554
85EZH2_27304074_Chip-Seq_ESCs_Mouse1.08222345
86NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07002034
87E2F1_21310950_ChIP-Seq_MCF-7_Human1.06506098
88SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05938538
89NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.05423845
90SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.04546973
91NFE2_27457419_Chip-Seq_LIVER_Mouse1.04192055
92AR_21572438_ChIP-Seq_LNCaP_Human1.03884776
93SOX2_18555785_Chip-Seq_ESCs_Mouse1.02859932
94MTF2_20144788_ChIP-Seq_MESCs_Mouse1.02450844
95SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02424603
96CRX_20693478_ChIP-Seq_RETINA_Mouse1.01310849
97RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01254629
98TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00191570
99SOX9_26525672_Chip-Seq_HEART_Mouse0.99705671
100* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98805350
101* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.98740819
102DROSHA_22980978_ChIP-Seq_HELA_Human0.98112562
103FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.97079954
104MYC_18940864_ChIP-ChIP_HL60_Human0.96925697
105SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96786711
106ESR1_20079471_ChIP-ChIP_T-47D_Human0.96535557
107EZH2_27294783_Chip-Seq_NPCs_Mouse0.96426655
108IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96244273
109CBP_20019798_ChIP-Seq_JUKART_Human0.96244273
110TTF2_22483619_ChIP-Seq_HELA_Human0.95469705
111KDM5A_27292631_Chip-Seq_BREAST_Human0.95237408
112JARID2_20075857_ChIP-Seq_MESCs_Mouse0.94753743
113* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.94748324
114P300_19829295_ChIP-Seq_ESCs_Human0.94657864
115* ELF5_23300383_ChIP-Seq_T47D_Human0.94617196
116ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94608758
117CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.94463674
118XRN2_22483619_ChIP-Seq_HELA_Human0.93088156
119GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93038168
120MYC_18555785_ChIP-Seq_MESCs_Mouse0.92720239
121SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.92315107
122ZFX_18555785_Chip-Seq_ESCs_Mouse0.91894684
123DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91877888
124CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91723970
125AR_25329375_ChIP-Seq_VCAP_Human0.91628767
126STAT3_18555785_Chip-Seq_ESCs_Mouse0.91362235
127OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88856611
128* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.87756747
129SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.87466858
130SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.87273445
131DCP1A_22483619_ChIP-Seq_HELA_Human0.86874353
132POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.86325678
133CTCF_18555785_Chip-Seq_ESCs_Mouse0.86171207
134GABP_19822575_ChIP-Seq_HepG2_Human0.85121660
135PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.84950898
136OCT4_18555785_Chip-Seq_ESCs_Mouse0.84584468
137EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.84502169
138MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.84449888
139ZFP57_27257070_Chip-Seq_ESCs_Mouse0.83800156
140SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.83536473
141SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.82826666
142GATA1_22025678_ChIP-Seq_K562_Human0.82686300
143SMAD3_21741376_ChIP-Seq_EPCs_Human0.82416228
144SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.81888671
145EWS_26573619_Chip-Seq_HEK293_Human0.81768013
146SUZ12_18555785_Chip-Seq_ESCs_Mouse0.81420383
147* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.81353263
148RUNX1_27457419_Chip-Seq_LIVER_Mouse0.81167623
149SMAD1_18555785_Chip-Seq_ESCs_Mouse0.81092011
150FOXM1_23109430_ChIP-Seq_U2OS_Human0.81083035
151P300_18555785_Chip-Seq_ESCs_Mouse0.81064717
152JUN_21703547_ChIP-Seq_K562_Human0.80975479
153UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.80807386
154* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.80500988
155PHF8_20622853_ChIP-Seq_HELA_Human0.80341213
156TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.80298449
157SALL4_22934838_ChIP-ChIP_CD34+_Human0.77996692
158PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.77504156
159SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.77260982
160DNAJC2_21179169_ChIP-ChIP_NT2_Human0.76362919

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue5.26894582
2MP0002837_dystrophic_cardiac_calcinosis4.75713071
3MP0000751_myopathy4.06258861
4MP0004084_abnormal_cardiac_muscle4.05898485
5MP0000372_irregular_coat_pigmentation3.94548708
6MP0004215_abnormal_myocardial_fiber3.79815353
7MP0000749_muscle_degeneration3.53697805
8MP0004036_abnormal_muscle_relaxation3.46288668
9MP0010234_abnormal_vibrissa_follicle3.01980404
10MP0004130_abnormal_muscle_cell2.89552486
11MP0006036_abnormal_mitochondrial_physio2.76707808
12MP0005330_cardiomyopathy2.75876244
13MP0004859_abnormal_synaptic_plasticity2.67958254
14MP0004145_abnormal_muscle_electrophysio2.56911285
15MP0002972_abnormal_cardiac_muscle2.39022644
16MP0005620_abnormal_muscle_contractility2.38501680
17MP0005075_abnormal_melanosome_morpholog2.28017068
18MP0004087_abnormal_muscle_fiber2.25278894
19MP0003880_abnormal_central_pattern2.24650846
20MP0000015_abnormal_ear_pigmentation2.21422805
21MP0004484_altered_response_of2.19412893
22MP0008775_abnormal_heart_ventricle2.17910322
23MP0010094_abnormal_chromosome_stability2.17404353
24MP0009046_muscle_twitch2.13484111
25MP0004233_abnormal_muscle_weight2.11606017
26MP0005408_hypopigmentation2.10888403
27MP0002106_abnormal_muscle_physiology2.03313281
28MP0006035_abnormal_mitochondrial_morpho2.02990489
29MP0003137_abnormal_impulse_conducting2.01173075
30MP0008058_abnormal_DNA_repair1.98926509
31MP0002269_muscular_atrophy1.94738112
32MP0003221_abnormal_cardiomyocyte_apopto1.90277763
33MP0003635_abnormal_synaptic_transmissio1.88417940
34MP0000747_muscle_weakness1.87188670
35MP0001544_abnormal_cardiovascular_syste1.80483581
36MP0005385_cardiovascular_system_phenoty1.80483581
37MP0000750_abnormal_muscle_regeneration1.80129328
38MP0000569_abnormal_digit_pigmentation1.78663055
39MP0006138_congestive_heart_failure1.78609329
40MP0002332_abnormal_exercise_endurance1.77956359
41MP0002877_abnormal_melanocyte_morpholog1.74012966
42MP0009745_abnormal_behavioral_response1.72661718
43MP0000759_abnormal_skeletal_muscle1.70234739
44MP0008057_abnormal_DNA_replication1.70201741
45MP0004085_abnormal_heartbeat1.69516798
46MP0005369_muscle_phenotype1.67419268
47MP0005670_abnormal_white_adipose1.64996774
48MP0002064_seizures1.63667915
49MP0000013_abnormal_adipose_tissue1.62598610
50MP0002736_abnormal_nociception_after1.57918145
51MP0004270_analgesia1.52665297
52MP0001968_abnormal_touch/_nociception1.50799122
53MP0002063_abnormal_learning/memory/cond1.46893554
54MP0005171_absent_coat_pigmentation1.43700717
55MP0002272_abnormal_nervous_system1.43313533
56MP0004043_abnormal_pH_regulation1.42062968
57MP0005332_abnormal_amino_acid1.39009309
58MP0010630_abnormal_cardiac_muscle1.38807612
59MP0001661_extended_life_span1.38175283
60MP0005666_abnormal_adipose_tissue1.35769728
61MP0005174_abnormal_tail_pigmentation1.34980525
62MP0004147_increased_porphyrin_level1.33804676
63MP0002166_altered_tumor_susceptibility1.32164097
64MP0003111_abnormal_nucleus_morphology1.30669855
65MP0009780_abnormal_chondrocyte_physiolo1.29063305
66MP0002822_catalepsy1.27813335
67MP0003693_abnormal_embryo_hatching1.27663591
68MP0004924_abnormal_behavior1.27162724
69MP0005386_behavior/neurological_phenoty1.27162724
70MP0004957_abnormal_blastocyst_morpholog1.26672418
71MP0002572_abnormal_emotion/affect_behav1.24269913
72MP0003186_abnormal_redox_activity1.23889476
73MP0000371_diluted_coat_color1.22706992
74MP0002734_abnormal_mechanical_nocicepti1.21556909
75MP0001529_abnormal_vocalization1.19930950
76MP0002067_abnormal_sensory_capabilities1.15720610
77MP0002095_abnormal_skin_pigmentation1.13461897
78MP0002090_abnormal_vision1.13214238
79MP0005535_abnormal_body_temperature1.11490572
80MP0003950_abnormal_plasma_membrane1.11372844
81MP0002127_abnormal_cardiovascular_syste1.10891936
82MP0003122_maternal_imprinting1.09991542
83MP0005266_abnormal_metabolism1.09806605
84MP0009697_abnormal_copulation1.09093240
85MP0002735_abnormal_chemical_nociception1.08932490
86MP0004142_abnormal_muscle_tone1.08526717
87MP0002971_abnormal_brown_adipose1.07263007
88MP0003786_premature_aging1.05658294
89MP0002909_abnormal_adrenal_gland1.04308612
90MP0002638_abnormal_pupillary_reflex1.03129776
91MP0008569_lethality_at_weaning1.02355665
92MP0005379_endocrine/exocrine_gland_phen1.01362218
93MP0001486_abnormal_startle_reflex1.01073371
94MP0002006_tumorigenesis1.00731857
95MP0003123_paternal_imprinting0.99999109
96MP0001440_abnormal_grooming_behavior0.97898118
97MP0005646_abnormal_pituitary_gland0.96513351
98MP0002102_abnormal_ear_morphology0.95977971
99MP0002163_abnormal_gland_morphology0.95752369
100MP0001501_abnormal_sleep_pattern0.95323255
101MP0003077_abnormal_cell_cycle0.95004759
102MP0003787_abnormal_imprinting0.91810008
103MP0005375_adipose_tissue_phenotype0.83824735
104MP0002876_abnormal_thyroid_physiology0.81912342
105MP0002396_abnormal_hematopoietic_system0.81545869
106MP0003879_abnormal_hair_cell0.80042697
107MP0001970_abnormal_pain_threshold0.80020966
108MP0000230_abnormal_systemic_arterial0.79820421
109MP0002009_preneoplasia0.78659371
110MP0008007_abnormal_cellular_replicative0.76919646
111MP0003828_pulmonary_edema0.76472763
112MP0004185_abnormal_adipocyte_glucose0.75879397
113MP0002066_abnormal_motor_capabilities/c0.75098454
114MP0008877_abnormal_DNA_methylation0.74521690
115MP0005253_abnormal_eye_physiology0.73800878
116MP0000003_abnormal_adipose_tissue0.70611628
117MP0006276_abnormal_autonomic_nervous0.69931135
118MP0004811_abnormal_neuron_physiology0.68819850
119MP0003718_maternal_effect0.67755165
120MP0002693_abnormal_pancreas_physiology0.67736171
121MP0001765_abnormal_ion_homeostasis0.67325951
122MP0002108_abnormal_muscle_morphology0.67157846
123MP0002078_abnormal_glucose_homeostasis0.67045996
124MP0001984_abnormal_olfaction0.66993525
125MP0005452_abnormal_adipose_tissue0.66934489
126MP0004381_abnormal_hair_follicle0.65333971
127MP0005636_abnormal_mineral_homeostasis0.64800989
128MP0003329_amyloid_beta_deposits0.64789975
129MP0002938_white_spotting0.64104033
130MP0001905_abnormal_dopamine_level0.64028364
131MP0008004_abnormal_stomach_pH0.63855236
132MP0002733_abnormal_thermal_nociception0.62990691
133MP0008872_abnormal_physiological_respon0.62970290
134MP0000358_abnormal_cell_content/0.60550239
135MP0005584_abnormal_enzyme/coenzyme_acti0.59467541
136MP0000266_abnormal_heart_morphology0.58834670
137MP0003806_abnormal_nucleotide_metabolis0.58255511
138MP0005165_increased_susceptibility_to0.55506291
139MP0003567_abnormal_fetal_cardiomyocyte0.51373863
140MP0002557_abnormal_social/conspecific_i0.50926225

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)5.36765634
2Abnormal mitochondria in muscle tissue (HP:0008316)5.12436595
3Exercise-induced muscle cramps (HP:0003710)5.08154815
4Acute necrotizing encephalopathy (HP:0006965)4.96627174
5Myoglobinuria (HP:0002913)4.74291182
6Abnormality of glycolysis (HP:0004366)4.56928609
7Increased serum pyruvate (HP:0003542)4.56928609
8Sudden death (HP:0001699)4.50868932
9Hepatic necrosis (HP:0002605)4.47593239
10Hepatocellular necrosis (HP:0001404)4.34101242
11Acute encephalopathy (HP:0006846)4.24177628
12Progressive macrocephaly (HP:0004481)4.22412986
13Mitochondrial inheritance (HP:0001427)4.10479405
14Increased CSF lactate (HP:0002490)4.09300772
15Calf muscle hypertrophy (HP:0008981)4.08549089
16Pheochromocytoma (HP:0002666)4.03232160
17Rhabdomyolysis (HP:0003201)4.00183341
18Muscle hypertrophy of the lower extremities (HP:0008968)3.96540776
19Abnormality of alanine metabolism (HP:0010916)3.94724427
20Hyperalaninemia (HP:0003348)3.94724427
21Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.94724427
22Neuroendocrine neoplasm (HP:0100634)3.79328361
23Focal motor seizures (HP:0011153)3.68567734
24Palpitations (HP:0001962)3.47009117
25Lactic acidosis (HP:0003128)3.42190253
26Exercise intolerance (HP:0003546)3.40633522
27Abnormality of the calf musculature (HP:0001430)3.33763255
28Atrial fibrillation (HP:0005110)3.27250758
29Cerebral edema (HP:0002181)3.22302115
30Ventricular tachycardia (HP:0004756)3.22212764
31Increased muscle lipid content (HP:0009058)3.11601576
32Conjunctival hamartoma (HP:0100780)3.06369459
33Primary atrial arrhythmia (HP:0001692)3.06056882
34Respiratory failure (HP:0002878)3.05890345
35Supraventricular tachycardia (HP:0004755)3.01797056
36Myotonia (HP:0002486)2.97437222
37Muscle stiffness (HP:0003552)2.94372439
38Supraventricular arrhythmia (HP:0005115)2.93704305
39Lipoatrophy (HP:0100578)2.91583475
40Ragged-red muscle fibers (HP:0003200)2.91428838
41Muscle fiber splitting (HP:0003555)2.81903644
42Increased intramyocellular lipid droplets (HP:0012240)2.81317732
43Increased serum lactate (HP:0002151)2.80058601
44Oligomenorrhea (HP:0000876)2.78345909
45Muscle fiber inclusion bodies (HP:0100299)2.76961427
46Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.75592960
47Decreased activity of mitochondrial respiratory chain (HP:0008972)2.75592960
48Heart block (HP:0012722)2.75124198
49EMG: myopathic abnormalities (HP:0003458)2.73589870
50Atonic seizures (HP:0010819)2.72255283
51Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.70546077
52Dicarboxylic aciduria (HP:0003215)2.63013892
53Abnormality of dicarboxylic acid metabolism (HP:0010995)2.63013892
54Neoplasm of the adrenal gland (HP:0100631)2.60521410
55Syncope (HP:0001279)2.54104168
56Abnormal gallbladder physiology (HP:0012438)2.53254240
57Cholecystitis (HP:0001082)2.53254240
58Subaortic stenosis (HP:0001682)2.52778103
59Abnormality of the left ventricular outflow tract (HP:0011103)2.52778103
60Abnormal atrioventricular conduction (HP:0005150)2.52289284
61Neoplasm of the peripheral nervous system (HP:0100007)2.52267592
62Difficulty running (HP:0009046)2.52264458
63Nemaline bodies (HP:0003798)2.50502492
64Neoplasm of head and neck (HP:0012288)2.50333741
65Esophageal neoplasm (HP:0100751)2.50333741
66Dilated cardiomyopathy (HP:0001644)2.49345158
67Dysmetric saccades (HP:0000641)2.48694534
68Degeneration of anterior horn cells (HP:0002398)2.46486907
69Abnormality of the anterior horn cell (HP:0006802)2.46486907
70Bundle branch block (HP:0011710)2.43387461
71Hyperventilation (HP:0002883)2.43067041
72Hyporeflexia of lower limbs (HP:0002600)2.42727745
73Epileptic encephalopathy (HP:0200134)2.41983610
74Prolonged QT interval (HP:0001657)2.40430010
75Ventricular arrhythmia (HP:0004308)2.39606250
76Left ventricular hypertrophy (HP:0001712)2.39524641
77Ketoacidosis (HP:0001993)2.36909247
78Patchy hypopigmentation of hair (HP:0011365)2.36791367
79Ventricular fibrillation (HP:0001663)2.35945894
80Cerebral hypomyelination (HP:0006808)2.35917070
81Optic disc pallor (HP:0000543)2.35579424
82Tongue fasciculations (HP:0001308)2.34138727
83Abnormality of fatty-acid metabolism (HP:0004359)2.33997357
84Hypokinesia (HP:0002375)2.33107704
85Athetosis (HP:0002305)2.32269969
86Leukodystrophy (HP:0002415)2.27156824
87Horizontal nystagmus (HP:0000666)2.24011628
88Increased hepatocellular lipid droplets (HP:0006565)2.21077078
89Type 1 muscle fiber predominance (HP:0003803)2.20467773
90Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.20058192
91CNS demyelination (HP:0007305)2.18388204
92Increased connective tissue (HP:0009025)2.18275541
93White forelock (HP:0002211)2.15139247
94Febrile seizures (HP:0002373)2.13888049
95Emotional lability (HP:0000712)2.12351707
96Neck muscle weakness (HP:0000467)2.11809581
97Methylmalonic aciduria (HP:0012120)2.10715946
98Resting tremor (HP:0002322)2.09251338
99Abnormal EKG (HP:0003115)2.08408722
100Rimmed vacuoles (HP:0003805)2.06719383
101Hamartoma of the eye (HP:0010568)2.05476557
102Microvesicular hepatic steatosis (HP:0001414)2.05064875
103Myokymia (HP:0002411)2.04848369
104Hypoglycemic coma (HP:0001325)2.04502186
105Ocular albinism (HP:0001107)2.02868921
106Atrioventricular block (HP:0001678)2.01772481
107Generalized aminoaciduria (HP:0002909)2.00296844
108Absence seizures (HP:0002121)1.98946592
109Lipid accumulation in hepatocytes (HP:0006561)1.98880331
110Abnormality of the vocal cords (HP:0008777)1.98525531
111Right ventricular cardiomyopathy (HP:0011663)1.97179711
112Tinnitus (HP:0000360)1.96205652
113Lethargy (HP:0001254)1.95778238
114Metabolic acidosis (HP:0001942)1.93527121
115Increased variability in muscle fiber diameter (HP:0003557)1.93432946
116Blue irides (HP:0000635)1.90529404
117Hyperglycinuria (HP:0003108)1.90157456
1183-Methylglutaconic aciduria (HP:0003535)1.88284642
119Generalized tonic-clonic seizures (HP:0002069)1.88138301
120Asymmetric septal hypertrophy (HP:0001670)1.86925951
121Abnormality of skeletal muscle fiber size (HP:0012084)1.86620635
122Albinism (HP:0001022)1.86497965
123Progressive external ophthalmoplegia (HP:0000590)1.85580271
124Muscle fibrillation (HP:0010546)1.84620566
125Hypoplasia of the fovea (HP:0007750)1.80198196
126Aplasia/Hypoplasia of the fovea (HP:0008060)1.80198196
127Megaloblastic anemia (HP:0001889)1.79564064
128Hyperammonemia (HP:0001987)1.79481901
129Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.79009106
130Iris hypopigmentation (HP:0007730)1.77874559
131Heterochromia iridis (HP:0001100)1.74856605
132Abnormality of vitamin B metabolism (HP:0004340)1.74771818

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK34.79801612
2PDK44.79801612
3NEK14.19684317
4OBSCN3.68387248
5MST43.27813463
6PDK22.93099030
7CASK2.87900718
8PHKG12.69689480
9PHKG22.69689480
10MAP3K122.61978359
11MYLK2.52925898
12NME12.30817041
13TTN2.27597829
14MAP3K42.18841083
15LMTK22.14368159
16MAP2K72.13062005
17TSSK62.07318179
18WEE12.00622992
19CDK191.99880240
20BMPR21.98803507
21TRIM281.90713161
22BCKDK1.87157550
23CCNB11.86512699
24NTRK31.84003046
25MAP2K41.72807796
26PBK1.69362918
27PLK21.60351530
28STK241.59020812
29TTK1.54807202
30MST1R1.52991148
31PINK11.52686593
32DAPK11.42228306
33AKT31.38632351
34MINK11.33449339
35PIK3CA1.25437231
36FRK1.23770697
37EPHA41.22263236
38EIF2AK11.21565585
39PKN21.16456312
40SRPK11.10980812
41MAP4K21.05878479
42BMPR1B1.03645552
43ACVR1B1.02221781
44LIMK11.01348229
45NEK90.99348320
46PRPF4B0.98571748
47DAPK20.96790176
48NME20.95225705
49STK390.92555583
50AKT20.91933424
51MUSK0.91729626
52TRIB30.91649205
53PNCK0.91416334
54MAPK120.82371685
55ILK0.81554025
56MAPKAPK50.80965640
57OXSR10.80764325
58PRKCG0.79759720
59VRK20.78759075
60ALK0.77693673
61CAMK2D0.75176773
62SGK20.74856800
63CAMK2A0.74685175
64TRPM70.74035488
65ARAF0.73898846
66DAPK30.73141810
67VRK10.73039107
68BRAF0.69229731
69MAP3K90.67595740
70PLK40.66315177
71STK38L0.66255532
72MARK10.65648084
73GRK50.65618374
74CAMKK20.64405680
75EIF2AK20.63743473
76BCR0.63375071
77PLK10.62883581
78BRSK20.62804368
79STK30.62729436
80ZAK0.62148232
81SIK30.60427850
82BRSK10.59240000
83SGK4940.56522444
84SGK2230.56522444
85CAMK10.56104099
86GRK70.55510273
87STK160.55043982
88PTK2B0.54026423
89PAK60.52980492
90CDK50.52808423
91RIPK40.52601897
92SCYL20.51887111
93MKNK20.50257456
94NUAK10.49924751
95PRKAA10.49300611
96CAMK2G0.48196571
97DMPK0.47865869
98CDC42BPA0.47796228
99PRKCE0.47272490
100SGK30.47082942
101CDK80.46891205
102PRKCI0.46225665
103CDK180.46154359
104MAP3K50.46048509
105CAMK2B0.45564608
106KSR10.45540419
107PDK10.45418610
108PAK30.45306494
109PRKD30.45061580
110RAF10.44060398
111PLK30.43308981
112STK380.43164119
113TIE10.42987686
114BUB10.42399206
115AURKB0.41793452
116CDK140.41738158
117MAPK130.41582913
118MAP2K60.40401885
119CDK150.40340426
120PRKAA20.40031299
121PRKACA0.39700154
122ROCK10.39393119
123MAP2K10.38798275
124CAMKK10.38433333
125PDPK10.38154767
126MAPKAPK30.38153233
127CSNK1G30.37852878
128LATS20.36521654
129ATR0.36395519
130NEK60.35827041
131PRKCH0.35033059
132STK40.35001045
133CDK11A0.33725477
134PRKACB0.33581679
135MAP3K20.31527341
136FER0.31371367
137MAP3K60.31136755
138ATM0.30081647
139ROCK20.30024156
140TESK10.29804487
141EIF2AK30.29257934
142WNK40.28594460
143ERBB30.28308622
144PRKACG0.27683059

Predicted pathways (KEGG)

RankGene SetZ-score
1* Citrate cycle (TCA cycle)_Homo sapiens_hsa000206.86536033
2* 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.73176689
3Oxidative phosphorylation_Homo sapiens_hsa001903.72244113
4Parkinsons disease_Homo sapiens_hsa050123.41081359
5Propanoate metabolism_Homo sapiens_hsa006403.03946195
6Cardiac muscle contraction_Homo sapiens_hsa042602.96133150
7* Carbon metabolism_Homo sapiens_hsa012002.63539775
8Pyruvate metabolism_Homo sapiens_hsa006202.60495306
9Alzheimers disease_Homo sapiens_hsa050102.42995339
10Protein export_Homo sapiens_hsa030602.39499645
11Huntingtons disease_Homo sapiens_hsa050162.37617673
12Sulfur metabolism_Homo sapiens_hsa009202.18055007
13Vitamin B6 metabolism_Homo sapiens_hsa007502.17741662
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.13437361
15Synaptic vesicle cycle_Homo sapiens_hsa047212.09506245
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.93685685
17Collecting duct acid secretion_Homo sapiens_hsa049661.88482848
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.86310782
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.84022006
20Non-homologous end-joining_Homo sapiens_hsa034501.76810138
21Fatty acid metabolism_Homo sapiens_hsa012121.74461511
22Fatty acid degradation_Homo sapiens_hsa000711.72606802
23Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.68378082
24Nicotine addiction_Homo sapiens_hsa050331.66342674
25Dilated cardiomyopathy_Homo sapiens_hsa054141.65609781
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.60070824
27Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.57040752
28DNA replication_Homo sapiens_hsa030301.46707181
29Mismatch repair_Homo sapiens_hsa034301.39367987
30* Biosynthesis of amino acids_Homo sapiens_hsa012301.37331732
31Proteasome_Homo sapiens_hsa030501.34025388
32One carbon pool by folate_Homo sapiens_hsa006701.33057251
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.31658229
34Olfactory transduction_Homo sapiens_hsa047401.29676470
35Arginine and proline metabolism_Homo sapiens_hsa003301.25693254
36Arginine biosynthesis_Homo sapiens_hsa002201.24594448
37Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.21090622
38Fatty acid elongation_Homo sapiens_hsa000621.19002457
39Vibrio cholerae infection_Homo sapiens_hsa051101.16181208
40Butanoate metabolism_Homo sapiens_hsa006501.15035370
41Homologous recombination_Homo sapiens_hsa034401.14199479
42Circadian entrainment_Homo sapiens_hsa047131.14069346
43GABAergic synapse_Homo sapiens_hsa047271.12186246
44Nucleotide excision repair_Homo sapiens_hsa034201.04942063
45Morphine addiction_Homo sapiens_hsa050321.04877362
46Glucagon signaling pathway_Homo sapiens_hsa049221.03727994
47Fructose and mannose metabolism_Homo sapiens_hsa000511.00995570
48Calcium signaling pathway_Homo sapiens_hsa040200.99821477
49Glutathione metabolism_Homo sapiens_hsa004800.99353956
50Long-term potentiation_Homo sapiens_hsa047200.97213574
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.95179005
52Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.92901018
53Folate biosynthesis_Homo sapiens_hsa007900.91024671
54Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.88180351
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87526964
56Dopaminergic synapse_Homo sapiens_hsa047280.86429931
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.86075149
58Amphetamine addiction_Homo sapiens_hsa050310.84023015
59RNA transport_Homo sapiens_hsa030130.83323026
60Oxytocin signaling pathway_Homo sapiens_hsa049210.83302274
61RNA degradation_Homo sapiens_hsa030180.80606392
62Insulin secretion_Homo sapiens_hsa049110.79905203
63Fatty acid biosynthesis_Homo sapiens_hsa000610.79823511
64Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.79605894
65Basal transcription factors_Homo sapiens_hsa030220.78670979
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78064817
67RNA polymerase_Homo sapiens_hsa030200.76526439
68Renin secretion_Homo sapiens_hsa049240.73776309
69Gastric acid secretion_Homo sapiens_hsa049710.73185235
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.73099959
71Insulin signaling pathway_Homo sapiens_hsa049100.72784200
72Salivary secretion_Homo sapiens_hsa049700.70782048
73Pyrimidine metabolism_Homo sapiens_hsa002400.70202176
74Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.67226505
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66916856
76Galactose metabolism_Homo sapiens_hsa000520.65799664
77Taste transduction_Homo sapiens_hsa047420.65404937
78Nitrogen metabolism_Homo sapiens_hsa009100.64302491
79Glutamatergic synapse_Homo sapiens_hsa047240.63951317
80Mineral absorption_Homo sapiens_hsa049780.61414769
81Pentose phosphate pathway_Homo sapiens_hsa000300.59253035
82Tryptophan metabolism_Homo sapiens_hsa003800.59223088
83Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.58361938
84PPAR signaling pathway_Homo sapiens_hsa033200.56000732
85Tyrosine metabolism_Homo sapiens_hsa003500.55318215
86Maturity onset diabetes of the young_Homo sapiens_hsa049500.55264055
87Pancreatic secretion_Homo sapiens_hsa049720.53876853
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52936757
89Oocyte meiosis_Homo sapiens_hsa041140.51636825
90Base excision repair_Homo sapiens_hsa034100.51250187
91AMPK signaling pathway_Homo sapiens_hsa041520.51030800
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51009140
93Cholinergic synapse_Homo sapiens_hsa047250.49233582
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48998173
95HIF-1 signaling pathway_Homo sapiens_hsa040660.48633196
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.47271709
97Long-term depression_Homo sapiens_hsa047300.46834490
98beta-Alanine metabolism_Homo sapiens_hsa004100.45597075
99Aldosterone synthesis and secretion_Homo sapiens_hsa049250.44562813
100Cell cycle_Homo sapiens_hsa041100.44062205
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.43876778
102Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43675931
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42654805
104Vascular smooth muscle contraction_Homo sapiens_hsa042700.42522185
105Serotonergic synapse_Homo sapiens_hsa047260.41818282
106* Metabolic pathways_Homo sapiens_hsa011000.41248472
107cAMP signaling pathway_Homo sapiens_hsa040240.40813497
108Gap junction_Homo sapiens_hsa045400.40175628
109Selenocompound metabolism_Homo sapiens_hsa004500.39551640
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38249569
111Circadian rhythm_Homo sapiens_hsa047100.37649659
112Cyanoamino acid metabolism_Homo sapiens_hsa004600.37066224
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37008443
114Type I diabetes mellitus_Homo sapiens_hsa049400.36764078
115Fanconi anemia pathway_Homo sapiens_hsa034600.36665663
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36349945
117Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.34848106
118Purine metabolism_Homo sapiens_hsa002300.34736473
119Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33323505
120GnRH signaling pathway_Homo sapiens_hsa049120.30410910
121Drug metabolism - other enzymes_Homo sapiens_hsa009830.28765822
122Insulin resistance_Homo sapiens_hsa049310.28200007
123Starch and sucrose metabolism_Homo sapiens_hsa005000.28168871
124Spliceosome_Homo sapiens_hsa030400.28165204
125Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.27831494
126Type II diabetes mellitus_Homo sapiens_hsa049300.27034589
127Phenylalanine metabolism_Homo sapiens_hsa003600.20529071
128Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.20272740
129Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.18474248
130Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.17642777
131Glycerolipid metabolism_Homo sapiens_hsa005610.16666135
132Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.16542446
133Tight junction_Homo sapiens_hsa045300.15551688
134Longevity regulating pathway - mammal_Homo sapiens_hsa042110.14225178
135Peroxisome_Homo sapiens_hsa041460.10876832
136Cocaine addiction_Homo sapiens_hsa050300.10400822
137Viral myocarditis_Homo sapiens_hsa054160.10006364
138Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.08973477
139Regulation of autophagy_Homo sapiens_hsa041400.07860882
140Rheumatoid arthritis_Homo sapiens_hsa053230.06966358

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