IDH3B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the beta subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* tricarboxylic acid cycle (GO:0006099)7.47583213
2regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)6.01750102
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.96862957
4* NADH metabolic process (GO:0006734)5.91652961
5regulation of acyl-CoA biosynthetic process (GO:0050812)5.84981556
6succinate metabolic process (GO:0006105)5.67986576
7regulation of cofactor metabolic process (GO:0051193)5.49403332
8regulation of coenzyme metabolic process (GO:0051196)5.49403332
9ATP synthesis coupled proton transport (GO:0015986)5.46432282
10energy coupled proton transport, down electrochemical gradient (GO:0015985)5.46432282
11respiratory electron transport chain (GO:0022904)5.39178219
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.34465807
13electron transport chain (GO:0022900)5.25900755
14deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.20295289
15oxaloacetate metabolic process (GO:0006107)5.19066832
16oxidative phosphorylation (GO:0006119)5.05550780
17lysine metabolic process (GO:0006553)5.02455104
18lysine catabolic process (GO:0006554)5.02455104
19ribosomal small subunit biogenesis (GO:0042274)5.01596068
20carnitine shuttle (GO:0006853)4.96618337
21regulation of mitochondrial translation (GO:0070129)4.64279541
22positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.56082012
23fatty acid transmembrane transport (GO:1902001)4.56012962
24aspartate family amino acid catabolic process (GO:0009068)4.47998988
25* 2-oxoglutarate metabolic process (GO:0006103)4.45852193
26regulation of sulfur metabolic process (GO:0042762)4.45847067
27ribosomal small subunit assembly (GO:0000028)4.42805675
28proteasome assembly (GO:0043248)4.31157497
29regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.30238379
30sarcomere organization (GO:0045214)4.28858877
31fatty acid beta-oxidation (GO:0006635)4.26628410
32negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.24331922
33regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.12777741
34branched-chain amino acid catabolic process (GO:0009083)4.07456221
35DNA strand elongation involved in DNA replication (GO:0006271)4.03793019
36establishment of integrated proviral latency (GO:0075713)4.02458378
37regulation of sequestering of triglyceride (GO:0010889)3.99082768
38regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.94590386
39negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.90455948
40negative regulation of ligase activity (GO:0051352)3.90455948
41positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.88657165
42protein maturation by protein folding (GO:0022417)3.87855757
43regulation of fatty acid oxidation (GO:0046320)3.86363359
44cardiac myofibril assembly (GO:0055003)3.86316794
45telomere maintenance via semi-conservative replication (GO:0032201)3.86207908
46DNA strand elongation (GO:0022616)3.86085363
47formation of translation preinitiation complex (GO:0001731)3.86020284
48regulation of cellular amino acid metabolic process (GO:0006521)3.85032344
49regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.83978425
50cardiac muscle contraction (GO:0060048)3.83158066
51carnitine transmembrane transport (GO:1902603)3.82163839
52fatty acid catabolic process (GO:0009062)3.81906959
53cellular ketone body metabolic process (GO:0046950)3.81691285
54DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.74853078
55ATP biosynthetic process (GO:0006754)3.73125559
56branched-chain amino acid metabolic process (GO:0009081)3.73006134
57anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.72135860
58acetyl-CoA metabolic process (GO:0006084)3.71781261
59carnitine transport (GO:0015879)3.71519332
60amino-acid betaine transport (GO:0015838)3.71519332
61cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.71095812
62intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.69615598
63signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.69615598
64muscle filament sliding (GO:0030049)3.69506609
65actin-myosin filament sliding (GO:0033275)3.69506609
66fatty acid oxidation (GO:0019395)3.69136830
67negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.68780976
68regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.68747291
69short-chain fatty acid metabolic process (GO:0046459)3.68094591
70regulation of relaxation of muscle (GO:1901077)3.65860240
71regulation of cell communication by electrical coupling (GO:0010649)3.64936062
72signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.64814851
73signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.64814851
74signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.64814851
75maturation of SSU-rRNA (GO:0030490)3.63437436
76lipid oxidation (GO:0034440)3.63083665
77signal transduction involved in DNA damage checkpoint (GO:0072422)3.60567484
78signal transduction involved in DNA integrity checkpoint (GO:0072401)3.60567484
79inner mitochondrial membrane organization (GO:0007007)3.59867338
80ribonucleoprotein complex biogenesis (GO:0022613)3.56825548
81* tricarboxylic acid metabolic process (GO:0072350)3.56647470
82establishment of viral latency (GO:0019043)3.56454466
83myofibril assembly (GO:0030239)3.56401929
84ribosomal large subunit biogenesis (GO:0042273)3.56307185
85valine metabolic process (GO:0006573)3.54729799
86signal transduction involved in cell cycle checkpoint (GO:0072395)3.51129552
87regulation of oxidative phosphorylation (GO:0002082)3.50495682
88sarcoplasmic reticulum calcium ion transport (GO:0070296)3.47372095
89quinone biosynthetic process (GO:1901663)3.44244124
90ubiquinone biosynthetic process (GO:0006744)3.44244124
91protein targeting to mitochondrion (GO:0006626)3.43176499
92positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.42974137
93ncRNA 3-end processing (GO:0043628)3.41659248
94antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.38831200
95gluconeogenesis (GO:0006094)3.37771356
96regulation of actin filament-based movement (GO:1903115)3.37747104
97negative regulation of potassium ion transmembrane transport (GO:1901380)3.37223998
98monocarboxylic acid catabolic process (GO:0072329)3.35682594
99biotin metabolic process (GO:0006768)3.33958122
100regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.33834917
101aerobic respiration (GO:0009060)3.33726066
102peptidyl-arginine omega-N-methylation (GO:0035247)3.30184989
103viral transcription (GO:0019083)3.26497856
104ketone body metabolic process (GO:1902224)3.26459880
105positive regulation of ligase activity (GO:0051351)3.26089162
106carnitine metabolic process (GO:0009437)3.26062020
107regulation of translational fidelity (GO:0006450)3.22928429
108hexose biosynthetic process (GO:0019319)3.19339955
109regulation of skeletal muscle contraction (GO:0014819)3.18059574
110ribosome biogenesis (GO:0042254)3.17043054
111antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.15102297
112striated muscle contraction (GO:0006941)3.14462026
113establishment of protein localization to mitochondrion (GO:0072655)3.14170055
114translational elongation (GO:0006414)3.13168895
115cellular component biogenesis (GO:0044085)3.12377236
116plasma membrane repair (GO:0001778)3.11309487
117proline biosynthetic process (GO:0006561)3.10507940
118cell communication by electrical coupling (GO:0010644)3.10051717
119pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.09654633
120regulation of ubiquitin-protein transferase activity (GO:0051438)3.09128967
121positive regulation of fatty acid oxidation (GO:0046321)3.08037259
122quaternary ammonium group transport (GO:0015697)3.06769864
123DNA unwinding involved in DNA replication (GO:0006268)3.06643500
124GDP-mannose metabolic process (GO:0019673)3.06107759
125negative regulation of B cell apoptotic process (GO:0002903)3.06059652
126translational termination (GO:0006415)3.04729926
127ventricular cardiac muscle cell action potential (GO:0086005)3.03934950
128cell communication involved in cardiac conduction (GO:0086065)3.03567971
129dicarboxylic acid catabolic process (GO:0043649)3.01361193
130tRNA aminoacylation for protein translation (GO:0006418)3.00148553
131purine nucleobase biosynthetic process (GO:0009113)2.99427163
132IMP biosynthetic process (GO:0006188)2.98761249
133amino-acid betaine metabolic process (GO:0006577)2.97948326
134ribosome assembly (GO:0042255)2.97641859
135protein localization to mitochondrion (GO:0070585)2.97017306
136regulation of ligase activity (GO:0051340)2.96350398
137telomere maintenance via recombination (GO:0000722)2.95787420
138regulation of membrane repolarization (GO:0060306)2.95723746
139deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.95075913
140purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.94010293
141cardiac muscle hypertrophy (GO:0003300)2.93868077
142purine nucleoside triphosphate biosynthetic process (GO:0009145)2.93815275
143regulation of cellular amine metabolic process (GO:0033238)2.93779950
144positive regulation of cell cycle arrest (GO:0071158)2.93775122
145hydrogen ion transmembrane transport (GO:1902600)2.93752260
146fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.92956386
147negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.92750866
148viral mRNA export from host cell nucleus (GO:0046784)2.91530451
149spliceosomal snRNP assembly (GO:0000387)2.91194089
150amino acid activation (GO:0043038)2.90890209
151tRNA aminoacylation (GO:0043039)2.90890209
152SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.90376841
153glycogen catabolic process (GO:0005980)2.89964551
154fatty acid homeostasis (GO:0055089)2.89721000
155nucleobase-containing small molecule interconversion (GO:0015949)2.88297128
156monosaccharide biosynthetic process (GO:0046364)2.88017115
157ubiquinone metabolic process (GO:0006743)2.87417819
158GMP metabolic process (GO:0046037)2.86468046
159membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.85905415
160regulation of cellular respiration (GO:0043457)2.85304468
161pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.84945723
162metallo-sulfur cluster assembly (GO:0031163)2.84843994
163iron-sulfur cluster assembly (GO:0016226)2.84843994
164purine nucleotide salvage (GO:0032261)2.84603607
165rRNA processing (GO:0006364)2.84456346
166chaperone-mediated protein transport (GO:0072321)2.84242594
167actin-mediated cell contraction (GO:0070252)2.83966063
168dicarboxylic acid biosynthetic process (GO:0043650)2.83440884
169glyoxylate metabolic process (GO:0046487)2.82316135
170translation (GO:0006412)2.82227236
171generation of precursor metabolites and energy (GO:0006091)2.82050932
172transcription-coupled nucleotide-excision repair (GO:0006283)2.81805409
173cotranslational protein targeting to membrane (GO:0006613)2.81299168
174striated muscle hypertrophy (GO:0014897)2.81232105
1752-deoxyribonucleotide biosynthetic process (GO:0009265)2.81007460
176deoxyribose phosphate biosynthetic process (GO:0046385)2.81007460
177protein targeting to ER (GO:0045047)2.80408416
178regulation of striated muscle contraction (GO:0006942)2.80333074
179pentose-phosphate shunt (GO:0006098)2.80155343
180regulation of sarcomere organization (GO:0060297)2.79590902
181* NAD metabolic process (GO:0019674)2.79560994
182translational initiation (GO:0006413)2.78630279
183establishment of protein localization to mitochondrial membrane (GO:0090151)2.78104014
184rRNA modification (GO:0000154)2.77200254
185IMP metabolic process (GO:0046040)2.76532567
186DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.75441947
187thioester biosynthetic process (GO:0035384)2.73785198

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse8.76447059
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.88178662
3* ESRRB_18555785_ChIP-Seq_MESCs_Mouse5.49198639
4TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.44179166
5E2F7_22180533_ChIP-Seq_HELA_Human4.22562762
6RXR_22158963_ChIP-Seq_LIVER_Mouse3.52629855
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.34666742
8PPARA_22158963_ChIP-Seq_LIVER_Mouse3.29410074
9EZH2_22144423_ChIP-Seq_EOC_Human2.93281004
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.92028242
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.83975707
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.62233555
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.50876083
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.44250305
15* GABP_17652178_ChIP-ChIP_JURKAT_Human2.43908723
16ZNF263_19887448_ChIP-Seq_K562_Human2.37250082
17* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.30704599
18* EST1_17652178_ChIP-ChIP_JURKAT_Human2.28278460
19* XRN2_22483619_ChIP-Seq_HELA_Human2.26883255
20MYC_19079543_ChIP-ChIP_MESCs_Mouse2.23610237
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.18752956
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.10554060
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.08352506
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.05079021
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.00570909
26NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.99596316
27* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.99348141
28* GABP_19822575_ChIP-Seq_HepG2_Human1.95591432
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.94235163
30CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.93464312
31E2F1_18555785_ChIP-Seq_MESCs_Mouse1.92124170
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.89080492
33FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.88791671
34DCP1A_22483619_ChIP-Seq_HELA_Human1.87579958
35E2F4_17652178_ChIP-ChIP_JURKAT_Human1.82502616
36PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.80331364
37TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.76362283
38* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.74278479
39NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.74022798
40CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.72821182
41ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.72362846
42EP300_21415370_ChIP-Seq_HL-1_Mouse1.69722865
43FOXP3_21729870_ChIP-Seq_TREG_Human1.63921882
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.61407699
45MYC_22102868_ChIP-Seq_BL_Human1.60872334
46ZFX_18555785_ChIP-Seq_MESCs_Mouse1.60732740
47SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.59898174
48DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.59426420
49VDR_23849224_ChIP-Seq_CD4+_Human1.58655219
50HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.56923473
51TBX20_22328084_ChIP-Seq_HEART_Mouse1.56876461
52TBX20_22080862_ChIP-Seq_HEART_Mouse1.56876461
53TTF2_22483619_ChIP-Seq_HELA_Human1.55343076
54REST_18959480_ChIP-ChIP_MESCs_Mouse1.52990051
55* CIITA_25753668_ChIP-Seq_RAJI_Human1.52807057
56VDR_21846776_ChIP-Seq_THP-1_Human1.50008664
57PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.49302390
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.48930028
59RARB_27405468_Chip-Seq_BRAIN_Mouse1.46162573
60SRF_21415370_ChIP-Seq_HL-1_Mouse1.46002344
61CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.44601932
62FOXM1_23109430_ChIP-Seq_U2OS_Human1.44338156
63CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.43687601
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.42800305
65SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.41562109
66TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.38227580
67* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.36574622
68KDM5A_27292631_Chip-Seq_BREAST_Human1.36155335
69NANOG_18555785_ChIP-Seq_MESCs_Mouse1.35902065
70BP1_19119308_ChIP-ChIP_Hs578T_Human1.35722003
71MYCN_18555785_ChIP-Seq_MESCs_Mouse1.35541343
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.32653560
73CLOCK_20551151_ChIP-Seq_293T_Human1.31495692
74GATA1_22025678_ChIP-Seq_K562_Human1.31440032
75TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.28598894
76PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.28560141
77EGR1_23403033_ChIP-Seq_LIVER_Mouse1.24936313
78* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.23500219
79* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.22766350
80FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.22555022
81ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.22005330
82* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.21121985
83DNAJC2_21179169_ChIP-ChIP_NT2_Human1.20884391
84ZNF274_21170338_ChIP-Seq_K562_Hela1.20661279
85SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.19983485
86GATA4_21415370_ChIP-Seq_HL-1_Mouse1.19463930
87* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.17563118
88* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.17448083
89REST_21632747_ChIP-Seq_MESCs_Mouse1.16782201
90PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16450486
91SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.16139455
92CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.16029551
93* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15505320
94* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.15434674
95NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.14136882
96HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.12056208
97THAP11_20581084_ChIP-Seq_MESCs_Mouse1.11041337
98SRY_22984422_ChIP-ChIP_TESTIS_Rat1.10560095
99BCL6_27268052_Chip-Seq_Bcells_Human1.08650094
100STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07707006
101FOXP1_21924763_ChIP-Seq_HESCs_Human1.06663998
102MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.05676100
103NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.05565217
104SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.05503950
105CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05362973
106KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05353955
107E2F1_21310950_ChIP-Seq_MCF-7_Human1.05186447
108POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.04780037
109DROSHA_22980978_ChIP-Seq_HELA_Human1.04337555
110LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.01609717
111ESR1_20079471_ChIP-ChIP_T-47D_Human1.01419693
112MAF_26560356_Chip-Seq_TH2_Human1.01151174
113MTF2_20144788_ChIP-Seq_MESCs_Mouse1.00632389
114SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.99660553
115CTCF_26484167_Chip-Seq_Bcells_Mouse0.99083748
116CTCF_18555785_ChIP-Seq_MESCs_Mouse0.97923482
117E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97595073
118GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97282601
119KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96755505
120RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.96754009
121LXR_22292898_ChIP-Seq_THP-1_Human0.95835707
122PU.1_20513432_ChIP-Seq_Bcells_Mouse0.95370184
123HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.94956907
124NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94908920
125CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.94217122
126ERG_21242973_ChIP-ChIP_JURKAT_Human0.94211963
127SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93975338
128TAF2_19829295_ChIP-Seq_ESCs_Human0.92598805
129P68_20966046_ChIP-Seq_HELA_Human0.92039385
130SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.90764594
131GBX2_23144817_ChIP-Seq_PC3_Human0.88589483
132YY1_21170310_ChIP-Seq_MESCs_Mouse0.88081944
133CTCF_27219007_Chip-Seq_Bcells_Human0.87567550
134SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.87383829
135TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84627313
136SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.84619629
137CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83475007
138SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.82220698
139* ETS1_20019798_ChIP-Seq_JURKAT_Human0.82175916
140EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.82066529
141HTT_18923047_ChIP-ChIP_STHdh_Human0.81090796
142BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.81056071
143CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.80816922
144YY1_22570637_ChIP-Seq_MALME-3M_Human0.80609601
145GATA1_19941827_ChIP-Seq_MEL_Mouse0.80557912
146ELF1_20517297_ChIP-Seq_JURKAT_Human0.79176200
147KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.79006224
148TET1_21451524_ChIP-Seq_MESCs_Mouse0.78531221
149FOXH1_21741376_ChIP-Seq_ESCs_Human0.77890301
150PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.76607960
151AUTS2_25519132_ChIP-Seq_293T-REX_Human0.75106692
152BCOR_27268052_Chip-Seq_Bcells_Human0.74253907
153RNF2_18974828_ChIP-Seq_MESCs_Mouse0.73656920
154EZH2_18974828_ChIP-Seq_MESCs_Mouse0.73656920
155BCAT_22108803_ChIP-Seq_LS180_Human0.72549589
156RAC3_21632823_ChIP-Seq_H3396_Human0.71752911
157PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.71374502
158ESR1_15608294_ChIP-ChIP_MCF-7_Human0.70908692
159JARID2_20075857_ChIP-Seq_MESCs_Mouse0.70498289
160SOX2_21211035_ChIP-Seq_LN229_Human0.69847010
161EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.69740923
162RAD21_21589869_ChIP-Seq_MESCs_Mouse0.69457975
163CTCF_21964334_ChIP-Seq_BJAB-B_Human0.69268627
164OCT4_20526341_ChIP-Seq_ESCs_Human0.68853755
165CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.68413847
166CBP_20019798_ChIP-Seq_JUKART_Human0.68409026
167IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.68409026
168TBX5_21415370_ChIP-Seq_HL-1_Mouse0.68194308

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.48045571
2MP0003646_muscle_fatigue5.19520261
3MP0000751_myopathy4.07161347
4MP0003693_abnormal_embryo_hatching3.88302896
5MP0004215_abnormal_myocardial_fiber3.63034282
6MP0010094_abnormal_chromosome_stability3.51468824
7MP0003111_abnormal_nucleus_morphology3.51363837
8MP0004084_abnormal_cardiac_muscle3.51151518
9MP0008058_abnormal_DNA_repair3.38964167
10MP0005451_abnormal_body_composition3.20716205
11MP0004130_abnormal_muscle_cell3.19010826
12MP0004036_abnormal_muscle_relaxation3.15830566
13MP0000749_muscle_degeneration2.95363314
14MP0006036_abnormal_mitochondrial_physio2.94760565
15MP0004957_abnormal_blastocyst_morpholog2.89071063
16MP0005330_cardiomyopathy2.86730584
17MP0003077_abnormal_cell_cycle2.66864158
18MP0003786_premature_aging2.64486484
19MP0005360_urolithiasis2.39615879
20MP0000372_irregular_coat_pigmentation2.30452116
21MP0008932_abnormal_embryonic_tissue2.29162672
22MP0005058_abnormal_lysosome_morphology2.29058328
23MP0009333_abnormal_splenocyte_physiolog2.27613710
24MP0008260_abnormal_autophagy2.27444281
25MP0008007_abnormal_cellular_replicative2.23505472
26MP0002139_abnormal_hepatobiliary_system2.22579517
27MP0004145_abnormal_muscle_electrophysio2.13721599
28MP0004087_abnormal_muscle_fiber2.13134799
29MP0006035_abnormal_mitochondrial_morpho2.11691005
30MP0002972_abnormal_cardiac_muscle2.09203220
31MP0005085_abnormal_gallbladder_physiolo2.07038066
32MP0005620_abnormal_muscle_contractility2.05255408
33MP0003806_abnormal_nucleotide_metabolis2.05225108
34MP0005670_abnormal_white_adipose2.03021094
35MP0004484_altered_response_of1.99417507
36MP0001853_heart_inflammation1.99178857
37MP0008775_abnormal_heart_ventricle1.98394254
38MP0002269_muscular_atrophy1.98093666
39MP0005365_abnormal_bile_salt1.90177068
40MP0003137_abnormal_impulse_conducting1.88737989
41MP0000747_muscle_weakness1.88380161
42MP0002106_abnormal_muscle_physiology1.88188322
43MP0004859_abnormal_synaptic_plasticity1.87554854
44MP0001727_abnormal_embryo_implantation1.84850023
45MP0003186_abnormal_redox_activity1.82951984
46MP0005385_cardiovascular_system_phenoty1.82249562
47MP0001544_abnormal_cardiovascular_syste1.82249562
48MP0005075_abnormal_melanosome_morpholog1.80535230
49MP0000358_abnormal_cell_content/1.78286337
50MP0005332_abnormal_amino_acid1.76423013
51MP0000750_abnormal_muscle_regeneration1.71424935
52MP0002822_catalepsy1.70941352
53MP0006138_congestive_heart_failure1.68858410
54MP0001730_embryonic_growth_arrest1.67035131
55MP0002332_abnormal_exercise_endurance1.66670178
56MP0001661_extended_life_span1.65864679
57MP0002019_abnormal_tumor_incidence1.60623862
58MP0008875_abnormal_xenobiotic_pharmacok1.60056194
59MP0005666_abnormal_adipose_tissue1.59011063
60MP0004233_abnormal_muscle_weight1.58807289
61MP0010329_abnormal_lipoprotein_level1.58720388
62MP0003221_abnormal_cardiomyocyte_apopto1.57405080
63MP0000759_abnormal_skeletal_muscle1.54741951
64MP0004085_abnormal_heartbeat1.53996630
65MP0003763_abnormal_thymus_physiology1.51750581
66MP0005369_muscle_phenotype1.48051171
67MP0004043_abnormal_pH_regulation1.47981753
68MP0005535_abnormal_body_temperature1.46349426
69MP0010630_abnormal_cardiac_muscle1.45486364
70MP0000313_abnormal_cell_death1.44365783
71MP0003880_abnormal_central_pattern1.42246419
72MP0005584_abnormal_enzyme/coenzyme_acti1.41954140
73MP0001873_stomach_inflammation1.39067724
74MP0004147_increased_porphyrin_level1.36648397
75MP0000350_abnormal_cell_proliferation1.33709788
76MP0003635_abnormal_synaptic_transmissio1.31213839
77MP0009046_muscle_twitch1.29406959
78MP0002971_abnormal_brown_adipose1.28732178
79MP0000013_abnormal_adipose_tissue1.28212744
80MP0003195_calcinosis1.27194513
81MP0005266_abnormal_metabolism1.23522301
82MP0008995_early_reproductive_senescence1.23257887
83MP0005319_abnormal_enzyme/_coenzyme1.23073050
84MP0002398_abnormal_bone_marrow1.22997819
85MP0002722_abnormal_immune_system1.22131701
86MP0009697_abnormal_copulation1.21475914
87MP0002877_abnormal_melanocyte_morpholog1.21150300
88MP0000703_abnormal_thymus_morphology1.19917065
89MP0002118_abnormal_lipid_homeostasis1.18383182
90MP0009745_abnormal_behavioral_response1.18349256
91MP0002909_abnormal_adrenal_gland1.17294505
92MP0005464_abnormal_platelet_physiology1.17290168
93MP0002396_abnormal_hematopoietic_system1.16315502
94MP0002132_abnormal_respiratory_system1.15081535
95MP0003172_abnormal_lysosome_physiology1.12917751
96MP0002429_abnormal_blood_cell1.12711196
97MP0005083_abnormal_biliary_tract1.12478796
98MP0000689_abnormal_spleen_morphology1.12226781
99MP0002080_prenatal_lethality1.11843224
100MP0003718_maternal_effect1.11446672
101MP0000015_abnormal_ear_pigmentation1.11052903
102MP0006082_CNS_inflammation1.10900864
103MP0002064_seizures1.08348328
104MP0000858_altered_metastatic_potential1.06183476
105MP0002078_abnormal_glucose_homeostasis1.02412825
106MP0001545_abnormal_hematopoietic_system1.02242569
107MP0005397_hematopoietic_system_phenotyp1.02242569
108MP0009840_abnormal_foam_cell1.00600014
109MP0000230_abnormal_systemic_arterial1.00376285
110MP0002272_abnormal_nervous_system0.99683292
111MP0005375_adipose_tissue_phenotype0.99281867
112MP0000490_abnormal_crypts_of0.99030450
113MP0005386_behavior/neurological_phenoty0.96364354
114MP0004924_abnormal_behavior0.96364354
115MP0000716_abnormal_immune_system0.95764191
116MP0009278_abnormal_bone_marrow0.94747349
117MP0003329_amyloid_beta_deposits0.92908919
118MP0002736_abnormal_nociception_after0.92714002
119MP0002063_abnormal_learning/memory/cond0.92352788
120MP0003252_abnormal_bile_duct0.91145529
121MP0002127_abnormal_cardiovascular_syste0.90589083
122MP0004510_myositis0.90166555
123MP0005501_abnormal_skin_physiology0.89254277
124MP0001968_abnormal_touch/_nociception0.89096817
125MP0003656_abnormal_erythrocyte_physiolo0.88887376
126MP0002420_abnormal_adaptive_immunity0.88555736
127MP0003828_pulmonary_edema0.87477984
128MP0005408_hypopigmentation0.86866462
129MP0001819_abnormal_immune_cell0.86473786
130MP0008872_abnormal_physiological_respon0.86409582
131MP0005671_abnormal_response_to0.85515311
132MP0001529_abnormal_vocalization0.82811273
133MP0004142_abnormal_muscle_tone0.82169289
134MP0005025_abnormal_response_to0.81693343
135MP0005384_cellular_phenotype0.80860314
136MP0003436_decreased_susceptibility_to0.80704073
137MP0001764_abnormal_homeostasis0.79617827
138MP0002723_abnormal_immune_serum0.78916606
139MP0005165_increased_susceptibility_to0.78417685
140MP0001440_abnormal_grooming_behavior0.77737418
141MP0002452_abnormal_antigen_presenting0.77683861
142MP0003191_abnormal_cellular_cholesterol0.77029903
143MP0000609_abnormal_liver_physiology0.76825614
144MP0001835_abnormal_antigen_presentation0.76348521
145MP0009643_abnormal_urine_homeostasis0.75764216
146MP0005000_abnormal_immune_tolerance0.75662973
147MP0002572_abnormal_emotion/affect_behav0.75562997
148MP0003315_abnormal_perineum_morphology0.75525558
149MP0005636_abnormal_mineral_homeostasis0.75415973
150MP0008569_lethality_at_weaning0.74650143
151MP0002067_abnormal_sensory_capabilities0.74453446
152MP0001765_abnormal_ion_homeostasis0.73791123
153MP0001800_abnormal_humoral_immune0.73534841
154MP0000343_altered_response_to0.73163166
155MP0004270_analgesia0.72980524
156MP0008469_abnormal_protein_level0.71968689
157MP0001697_abnormal_embryo_size0.71559230
158MP0001905_abnormal_dopamine_level0.70889426
159MP0005448_abnormal_energy_balance0.70797068
160MP0001501_abnormal_sleep_pattern0.70779033
161MP0009763_increased_sensitivity_to0.70454680
162MP0008874_decreased_physiological_sensi0.70393277
163MP0005334_abnormal_fat_pad0.69789593
164MP0002148_abnormal_hypersensitivity_rea0.69450907
165MP0005376_homeostasis/metabolism_phenot0.69045969
166MP0003879_abnormal_hair_cell0.68967784
167MP0005380_embryogenesis_phenotype0.68405493
168MP0001672_abnormal_embryogenesis/_devel0.68405493
169MP0004185_abnormal_adipocyte_glucose0.65620869

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)4.85380979
2Myoglobinuria (HP:0002913)4.75807170
3Abnormal mitochondria in muscle tissue (HP:0008316)4.65821748
4Hepatic necrosis (HP:0002605)4.62587195
5Sudden death (HP:0001699)4.59948725
6Acute necrotizing encephalopathy (HP:0006965)4.51069853
7Microvesicular hepatic steatosis (HP:0001414)4.44383968
8Acute encephalopathy (HP:0006846)4.30166183
9Hepatocellular necrosis (HP:0001404)4.26725608
10Exercise-induced muscle cramps (HP:0003710)4.19490474
11Cholecystitis (HP:0001082)4.08914127
12Calf muscle hypertrophy (HP:0008981)3.87699424
13Mitochondrial inheritance (HP:0001427)3.86708186
14Cerebral edema (HP:0002181)3.86128959
15Rhabdomyolysis (HP:0003201)3.79841830
16Progressive macrocephaly (HP:0004481)3.78519516
17Increased CSF lactate (HP:0002490)3.77834511
18Increased muscle lipid content (HP:0009058)3.69996720
19Muscle hypertrophy of the lower extremities (HP:0008968)3.68136650
20Palpitations (HP:0001962)3.65449110
21Progressive muscle weakness (HP:0003323)3.61177503
22Ketoacidosis (HP:0001993)3.59976954
23Abnormality of fatty-acid metabolism (HP:0004359)3.56023322
24Lactic acidosis (HP:0003128)3.50154729
25Abnormality of dicarboxylic acid metabolism (HP:0010995)3.48232942
26Dicarboxylic aciduria (HP:0003215)3.48232942
27Hypoglycemic coma (HP:0001325)3.42874308
28Ventricular tachycardia (HP:0004756)3.40990542
29Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.36060144
30Abnormality of alanine metabolism (HP:0010916)3.36060144
31Hyperalaninemia (HP:0003348)3.36060144
32Increased intramyocellular lipid droplets (HP:0012240)3.32514591
33Increased serum pyruvate (HP:0003542)3.31665703
34Abnormality of glycolysis (HP:0004366)3.31665703
35Ketosis (HP:0001946)3.31468527
36Hyperglycinuria (HP:0003108)3.25400052
37Hyperammonemia (HP:0001987)3.17727373
38Ragged-red muscle fibers (HP:0003200)3.10631741
39Atrial fibrillation (HP:0005110)3.04073813
40Pheochromocytoma (HP:0002666)3.01049660
41Decreased activity of mitochondrial respiratory chain (HP:0008972)3.00822999
42Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.00822999
43Reticulocytopenia (HP:0001896)2.99287968
44Abnormality of the calf musculature (HP:0001430)2.99215026
45Myopathic facies (HP:0002058)2.98855018
46Muscle fiber splitting (HP:0003555)2.97105648
47Generalized aminoaciduria (HP:0002909)2.96432540
48Nemaline bodies (HP:0003798)2.89598599
49Myotonia (HP:0002486)2.89250179
50Neuroendocrine neoplasm (HP:0100634)2.88577698
51Exercise intolerance (HP:0003546)2.85777929
52Primary atrial arrhythmia (HP:0001692)2.85592334
53Syncope (HP:0001279)2.85464143
54Abnormality of glycine metabolism (HP:0010895)2.83520118
55Abnormality of serine family amino acid metabolism (HP:0010894)2.83520118
56Supraventricular tachycardia (HP:0004755)2.83193686
57Respiratory failure (HP:0002878)2.82432680
58Lethargy (HP:0001254)2.82373832
59Reduced antithrombin III activity (HP:0001976)2.82225591
60Lipoatrophy (HP:0100578)2.81086880
61Muscle stiffness (HP:0003552)2.78276644
62Supraventricular arrhythmia (HP:0005115)2.75537373
63Cerebral hypomyelination (HP:0006808)2.75452224
64Round ear (HP:0100830)2.71983865
65Type I transferrin isoform profile (HP:0003642)2.71777521
66Bundle branch block (HP:0011710)2.70435971
67Increased serum lactate (HP:0002151)2.61363790
68Conjunctival hamartoma (HP:0100780)2.60838975
69Asymmetric septal hypertrophy (HP:0001670)2.60833928
70Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.59979945
71Centrally nucleated skeletal muscle fibers (HP:0003687)2.59009975
72Metabolic acidosis (HP:0001942)2.58381353
73Neoplasm of head and neck (HP:0012288)2.55146587
74Esophageal neoplasm (HP:0100751)2.55146587
75Lipid accumulation in hepatocytes (HP:0006561)2.53680941
76Dilated cardiomyopathy (HP:0001644)2.52609901
77EMG: myopathic abnormalities (HP:0003458)2.52213863
78Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.49542369
79Hyporeflexia of lower limbs (HP:0002600)2.48805484
80Testicular atrophy (HP:0000029)2.47923740
81Hyperglycinemia (HP:0002154)2.44155629
82Vomiting (HP:0002013)2.39843946
83Ventricular arrhythmia (HP:0004308)2.38009823
84Right ventricular cardiomyopathy (HP:0011663)2.37509064
85Abnormality of the anterior horn cell (HP:0006802)2.36745161
86Degeneration of anterior horn cells (HP:0002398)2.36745161
87Abnormal number of erythroid precursors (HP:0012131)2.36342559
88Prolonged QT interval (HP:0001657)2.36020825
89Abnormality of the left ventricular outflow tract (HP:0011103)2.35648907
90Subaortic stenosis (HP:0001682)2.35648907
91Atrioventricular block (HP:0001678)2.35348209
92Ventricular fibrillation (HP:0001663)2.34712415
93Difficulty running (HP:0009046)2.34602015
94Heart block (HP:0012722)2.34326045
95Abnormality of cells of the erythroid lineage (HP:0012130)2.32921361
96Gout (HP:0001997)2.31654131
97CNS demyelination (HP:0007305)2.30658165
98Progressive external ophthalmoplegia (HP:0000590)2.30266185
99Focal motor seizures (HP:0011153)2.27533071
100Aplastic anemia (HP:0001915)2.26281022
101Dysmetric saccades (HP:0000641)2.23582843
102Athetosis (HP:0002305)2.22904439
103Rough bone trabeculation (HP:0100670)2.22257392
104Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.21905027
105Multiple enchondromatosis (HP:0005701)2.20542829
106Seborrheic dermatitis (HP:0001051)2.19470712
107Methylmalonic aciduria (HP:0012120)2.19027876
108Increased connective tissue (HP:0009025)2.15055336
109Abnormality of serum amino acid levels (HP:0003112)2.12645946
110Cholelithiasis (HP:0001081)2.11270598
111Neoplasm of the adrenal gland (HP:0100631)2.10773893
112Increased hepatocellular lipid droplets (HP:0006565)2.10500185
113Abnormal atrioventricular conduction (HP:0005150)2.09542401
114Muscle fiber inclusion bodies (HP:0100299)2.09204267
115Aplasia/Hypoplasia of the sacrum (HP:0008517)2.09024900
116Respiratory difficulties (HP:0002880)2.08883222
117Proximal tubulopathy (HP:0000114)2.08497947
118Oligomenorrhea (HP:0000876)2.07275485
119Abnormal gallbladder morphology (HP:0012437)2.06424581
120Abnormal protein glycosylation (HP:0012346)2.06205994
121Abnormal glycosylation (HP:0012345)2.06205994
122Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.06205994
123Abnormal protein N-linked glycosylation (HP:0012347)2.06205994
124Nausea (HP:0002018)2.05521569
125Hypertensive crisis (HP:0100735)2.01454731
126Emotional lability (HP:0000712)2.01188184
127Abnormality of reticulocytes (HP:0004312)1.99965952
128Hepatosplenomegaly (HP:0001433)1.99444464
129Pancytopenia (HP:0001876)1.99293376
130Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.98745206
131* Optic disc pallor (HP:0000543)1.97936851
132Tinnitus (HP:0000360)1.97040737
133Cerebral palsy (HP:0100021)1.96519641
134Leukodystrophy (HP:0002415)1.96390427
135Abnormal gallbladder physiology (HP:0012438)1.95312414
136Secondary amenorrhea (HP:0000869)1.87107626
137Abnormality of the gallbladder (HP:0005264)1.86499754
138Spastic paraparesis (HP:0002313)1.85915268
139Renal Fanconi syndrome (HP:0001994)1.84237029
140IgM deficiency (HP:0002850)1.83766610
141Premature ovarian failure (HP:0008209)1.83049419
142Epiphyseal stippling (HP:0010655)1.77984635
143Trismus (HP:0000211)1.77730466
144Vertebral compression fractures (HP:0002953)1.77351422
145Muscle fiber atrophy (HP:0100295)1.75627632
146Amniotic constriction ring (HP:0009775)1.75598046
147Abnormality of placental membranes (HP:0011409)1.75598046
148Macrocytic anemia (HP:0001972)1.75342831
149Distal lower limb muscle weakness (HP:0009053)1.72099731
150Granulocytopenia (HP:0001913)1.71553709
151Toxemia of pregnancy (HP:0100603)1.71393111
152Opisthotonus (HP:0002179)1.70665967
153Agammaglobulinemia (HP:0004432)1.69587405
154Cupped ribs (HP:0000887)1.68085574
155Obstructive lung disease (HP:0006536)1.67943476
156Chronic obstructive pulmonary disease (HP:0006510)1.67943476
157CNS hypomyelination (HP:0003429)1.65962735

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK34.46507853
2PDK44.46507853
3VRK24.43875222
4BCKDK4.34206202
5BUB13.59103676
6TESK23.34740680
7TTN3.33792936
8NEK13.24974014
9OBSCN3.22075900
10PHKG22.97245135
11PHKG12.97245135
12LMTK22.91049084
13MYLK2.79557069
14PDK22.65574067
15PINK12.50330958
16SRPK12.45721543
17MAP3K122.36848769
18TRIB32.27396845
19PBK2.26891642
20PKN22.24445806
21MAP2K42.06608473
22SMG12.06576484
23PIM21.95715964
24TESK11.91168626
25CDC71.88951680
26NME11.83623421
27MAP3K41.81167940
28NTRK31.72340022
29MUSK1.71609556
30TIE11.69215602
31SCYL21.62552869
32EIF2AK11.51911760
33EPHA41.50897341
34LIMK11.49783480
35IRAK31.49377489
36MAP2K71.44171801
37KIT1.39715972
38VRK11.33257694
39MAP4K11.29387122
40NME21.23762808
41ARAF1.21395607
42DAPK11.17012953
43FLT31.16265377
44CDK191.15169316
45FES1.12602640
46DAPK21.12334868
47MAPK121.10826555
48ERN11.10199654
49MAP3K91.09797987
50MAP3K71.08702642
51AURKA1.08466989
52GRK71.07895214
53MAP2K31.07376097
54MINK11.06964341
55CSNK1G31.06526198
56EPHA21.05123373
57PAK41.04663004
58PIK3CA0.98269882
59ATR0.96861428
60DAPK30.92948729
61LRRK20.92462462
62KSR20.91341296
63STK380.90966860
64GRK50.88662660
65TTK0.86748705
66ZAK0.85003122
67CAMK10.84806056
68CAMK2D0.83394467
69AURKB0.82802199
70MAP2K60.82744664
71CAMKK20.81765969
72CSNK1A1L0.81178179
73WNK40.81170189
74BRSK10.79528725
75PLK10.77043152
76CDK80.76581855
77ILK0.75239146
78MAP3K110.74246494
79PAK10.73255644
80RPS6KA40.73100415
81MAP3K50.73070694
82RPS6KA50.71183389
83PTK2B0.70289713
84CAMK2A0.69649849
85BRAF0.69620807
86MST1R0.69420806
87CDK70.68883706
88PDPK10.68091082
89CHEK20.67915883
90CDK40.67793479
91PDK10.67479067
92KDR0.66754452
93TBK10.66375780
94PAK30.65433204
95CAMK2G0.65364873
96PRKAA10.65025698
97MST40.64516399
98PRKAA20.63701336
99MAP3K80.62311861
100IKBKB0.61102119
101MAP4K20.61086766
102CDK11A0.60969023
103CDK140.60557490
104CAMKK10.58504108
105PRKCG0.58095972
106PAK60.57802200
107MAPKAPK50.56705565
108CSNK1G10.56061647
109MAP2K10.54594467
110MAPKAPK30.54074415
111CDK150.54004593
112STK240.53060576
113CDK180.52110324
114CSNK2A20.51989997
115CHEK10.51798200
116PRKACG0.51654567
117RPS6KB20.51437420
118CSNK2A10.50953549
119INSRR0.50689760
120TLK10.50596534
121CCNB10.50343054
122ALK0.49756829
123PRKACA0.49706015
124CAMK40.49642763
125STK100.48613550
126DMPK0.48562415
127EIF2AK30.48095099
128MAP3K130.48035875
129SYK0.47142551
130ICK0.46625019
131CDK90.46288591
132MAPK110.45730834
133PLK20.44333236
134CSNK1G20.43934266
135PRKD10.42852047
136TAOK20.41446032
137GRK60.38774802
138PRKACB0.38719573
139RIPK40.38130101
140CDK50.37639226
141AKT20.37252115
142WNK30.37242433
143RAF10.35634518
144SIK10.35532280
145RET0.33824007
146PRKCI0.33173137
147CAMK2B0.32964497
148CDK20.32675403
149PLK30.31662156
150SIK30.31644579
151KSR10.30624034
152TSSK60.30565936
153OXSR10.30089728
154STK40.29936061
155MAP3K10.29328753
156STK160.29318914
157ROCK10.28108506
158TNIK0.27910416
159PRKCH0.27661892
160CASK0.27480866
161WEE10.26884374
162ATM0.26847973
163PRKCE0.26354454
164PRKG20.26177890
165ADRBK10.25788241
166SGK30.25067257
167MAPK40.25066669
168RPS6KA30.25018993
169ABL20.24065618

Predicted pathways (KEGG)

RankGene SetZ-score
1* Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.52757479
2* 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.94959664
3DNA replication_Homo sapiens_hsa030303.74018961
4Propanoate metabolism_Homo sapiens_hsa006403.55314872
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.51111294
6Oxidative phosphorylation_Homo sapiens_hsa001903.27412776
7Mismatch repair_Homo sapiens_hsa034303.10483641
8Ribosome_Homo sapiens_hsa030103.04852939
9Parkinsons disease_Homo sapiens_hsa050123.00872995
10Fatty acid degradation_Homo sapiens_hsa000712.96655799
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.78484438
12Base excision repair_Homo sapiens_hsa034102.71066658
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.64831689
14Pyruvate metabolism_Homo sapiens_hsa006202.62278901
15* Carbon metabolism_Homo sapiens_hsa012002.53728551
16Cardiac muscle contraction_Homo sapiens_hsa042602.51683631
17Fatty acid metabolism_Homo sapiens_hsa012122.35320661
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.30159169
19Spliceosome_Homo sapiens_hsa030402.22495380
20Alzheimers disease_Homo sapiens_hsa050102.21975477
21RNA polymerase_Homo sapiens_hsa030202.16429233
22Butanoate metabolism_Homo sapiens_hsa006502.08756499
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.00077285
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.92283572
25Pyrimidine metabolism_Homo sapiens_hsa002401.89756895
26Huntingtons disease_Homo sapiens_hsa050161.80151720
27Nucleotide excision repair_Homo sapiens_hsa034201.65716354
28Homologous recombination_Homo sapiens_hsa034401.57859653
29Arginine biosynthesis_Homo sapiens_hsa002201.56971724
30Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.51826835
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.50866884
32PPAR signaling pathway_Homo sapiens_hsa033201.50540127
33* Biosynthesis of amino acids_Homo sapiens_hsa012301.47928960
34Non-homologous end-joining_Homo sapiens_hsa034501.44676196
35Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.43818845
36Fatty acid elongation_Homo sapiens_hsa000621.36608425
37Tryptophan metabolism_Homo sapiens_hsa003801.36356419
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.35698824
39beta-Alanine metabolism_Homo sapiens_hsa004101.31550390
40RNA transport_Homo sapiens_hsa030131.30964153
41Peroxisome_Homo sapiens_hsa041461.28564212
42Nitrogen metabolism_Homo sapiens_hsa009101.24124230
43Primary bile acid biosynthesis_Homo sapiens_hsa001201.23940350
44One carbon pool by folate_Homo sapiens_hsa006701.20676168
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.19698185
46Dilated cardiomyopathy_Homo sapiens_hsa054141.19635881
47Other glycan degradation_Homo sapiens_hsa005111.17631883
48Purine metabolism_Homo sapiens_hsa002301.11640275
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.09577113
50Primary immunodeficiency_Homo sapiens_hsa053401.09197732
51Collecting duct acid secretion_Homo sapiens_hsa049661.07593645
52Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.06422520
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.05092518
54Cysteine and methionine metabolism_Homo sapiens_hsa002701.04599466
55Cell cycle_Homo sapiens_hsa041100.97740485
56Synaptic vesicle cycle_Homo sapiens_hsa047210.97233639
57Glutathione metabolism_Homo sapiens_hsa004800.97041078
58Fanconi anemia pathway_Homo sapiens_hsa034600.93857381
59Phenylalanine metabolism_Homo sapiens_hsa003600.92812644
60Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.91491907
61Starch and sucrose metabolism_Homo sapiens_hsa005000.90852420
62Glucagon signaling pathway_Homo sapiens_hsa049220.89997453
63Fructose and mannose metabolism_Homo sapiens_hsa000510.89801708
64Systemic lupus erythematosus_Homo sapiens_hsa053220.84661875
65Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84023830
66Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.83673313
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.83561167
68Fatty acid biosynthesis_Homo sapiens_hsa000610.81218426
69Epstein-Barr virus infection_Homo sapiens_hsa051690.74236419
70Nicotine addiction_Homo sapiens_hsa050330.73420735
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.73086077
72Bile secretion_Homo sapiens_hsa049760.72767492
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72262659
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.70001563
75Calcium signaling pathway_Homo sapiens_hsa040200.69992566
76Folate biosynthesis_Homo sapiens_hsa007900.69280720
77Glycerolipid metabolism_Homo sapiens_hsa005610.66103726
78Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.65360754
79GABAergic synapse_Homo sapiens_hsa047270.63125617
80Circadian entrainment_Homo sapiens_hsa047130.62586237
81Viral myocarditis_Homo sapiens_hsa054160.62014740
82RNA degradation_Homo sapiens_hsa030180.60520589
83Antigen processing and presentation_Homo sapiens_hsa046120.60456322
84Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.60446676
85N-Glycan biosynthesis_Homo sapiens_hsa005100.60337911
86Olfactory transduction_Homo sapiens_hsa047400.59857029
87Pentose phosphate pathway_Homo sapiens_hsa000300.58911128
88Insulin signaling pathway_Homo sapiens_hsa049100.58413367
89Gastric acid secretion_Homo sapiens_hsa049710.57240584
90Tyrosine metabolism_Homo sapiens_hsa003500.56891707
91* Metabolic pathways_Homo sapiens_hsa011000.54828530
92Galactose metabolism_Homo sapiens_hsa000520.53676612
93Arginine and proline metabolism_Homo sapiens_hsa003300.53035823
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52950026
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50018708
96Long-term potentiation_Homo sapiens_hsa047200.49614675
97Salivary secretion_Homo sapiens_hsa049700.49394452
98Renin secretion_Homo sapiens_hsa049240.49264289
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49063016
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48664156
101Insulin resistance_Homo sapiens_hsa049310.47670830
102Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47236774
103Morphine addiction_Homo sapiens_hsa050320.45616383
104Taste transduction_Homo sapiens_hsa047420.44576352
105Sulfur relay system_Homo sapiens_hsa041220.44512494
106Insulin secretion_Homo sapiens_hsa049110.44163606
107Shigellosis_Homo sapiens_hsa051310.43654455
108Oxytocin signaling pathway_Homo sapiens_hsa049210.43468699
109mRNA surveillance pathway_Homo sapiens_hsa030150.43420396
110Caffeine metabolism_Homo sapiens_hsa002320.42819869
111Fat digestion and absorption_Homo sapiens_hsa049750.42072996
112Alcoholism_Homo sapiens_hsa050340.40282440
113Aldosterone synthesis and secretion_Homo sapiens_hsa049250.40048420
114Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39420732
115Viral carcinogenesis_Homo sapiens_hsa052030.38581899
116Steroid biosynthesis_Homo sapiens_hsa001000.38228832
117Proteasome_Homo sapiens_hsa030500.38199380
118cGMP-PKG signaling pathway_Homo sapiens_hsa040220.37521338
119Autoimmune thyroid disease_Homo sapiens_hsa053200.36285486
120Cyanoamino acid metabolism_Homo sapiens_hsa004600.36247388
121AMPK signaling pathway_Homo sapiens_hsa041520.36117558
122Graft-versus-host disease_Homo sapiens_hsa053320.36003989
123Bladder cancer_Homo sapiens_hsa052190.35974743
124Vibrio cholerae infection_Homo sapiens_hsa051100.35394230
125Sulfur metabolism_Homo sapiens_hsa009200.34648739
126Vitamin B6 metabolism_Homo sapiens_hsa007500.34341425
127Amphetamine addiction_Homo sapiens_hsa050310.34096445
128Herpes simplex infection_Homo sapiens_hsa051680.33511882
129Allograft rejection_Homo sapiens_hsa053300.33002676
130Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.32246862
131Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31362519
132Dopaminergic synapse_Homo sapiens_hsa047280.30266655
133Glutamatergic synapse_Homo sapiens_hsa047240.30037894
134Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29180316
135Drug metabolism - other enzymes_Homo sapiens_hsa009830.27871557
136SNARE interactions in vesicular transport_Homo sapiens_hsa041300.23791231
137Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.21228487
138Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.20577713
139Protein export_Homo sapiens_hsa030600.20235308
140Central carbon metabolism in cancer_Homo sapiens_hsa052300.19959777
141Chemical carcinogenesis_Homo sapiens_hsa052040.18924525
142Vascular smooth muscle contraction_Homo sapiens_hsa042700.18806206
143Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.17702655
144Apoptosis_Homo sapiens_hsa042100.17079866
145Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.16659873
146Legionellosis_Homo sapiens_hsa051340.16537826
147HTLV-I infection_Homo sapiens_hsa051660.16308641
148p53 signaling pathway_Homo sapiens_hsa041150.15808988
149Cholinergic synapse_Homo sapiens_hsa047250.14854221
150Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.14639907
151cAMP signaling pathway_Homo sapiens_hsa040240.14504317
152Asthma_Homo sapiens_hsa053100.14276364
153Oocyte meiosis_Homo sapiens_hsa041140.14033037
154RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.11471907

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