IDH3G

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the gamma subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. This gene is a candidate gene for periventricular heterotopia. Several alternatively spliced transcript variants of this gene have been described, but only some of their full length natures have been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* tricarboxylic acid cycle (GO:0006099)7.37853147
2NADH metabolic process (GO:0006734)6.99799988
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.54282551
4oxidative phosphorylation (GO:0006119)6.51615141
5ATP synthesis coupled proton transport (GO:0015986)5.87663405
6energy coupled proton transport, down electrochemical gradient (GO:0015985)5.87663405
7regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.86547698
8regulation of acyl-CoA biosynthetic process (GO:0050812)5.46272351
9respiratory electron transport chain (GO:0022904)5.33352298
10electron transport chain (GO:0022900)5.20567587
11regulation of cofactor metabolic process (GO:0051193)5.19999361
12regulation of coenzyme metabolic process (GO:0051196)5.19999361
13mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.17755187
14oxaloacetate metabolic process (GO:0006107)4.94714175
15protein maturation by protein folding (GO:0022417)4.86113751
16negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.79228451
17succinate metabolic process (GO:0006105)4.79109627
18quinone biosynthetic process (GO:1901663)4.68168422
19ubiquinone biosynthetic process (GO:0006744)4.68168422
20sarcomere organization (GO:0045214)4.52307299
21aerobic respiration (GO:0009060)4.36034840
22ribosomal small subunit assembly (GO:0000028)4.21548412
23regulation of cellular amino acid metabolic process (GO:0006521)4.19203358
24GDP-mannose metabolic process (GO:0019673)4.15211913
25regulation of sulfur metabolic process (GO:0042762)4.09103310
26mitochondrial respiratory chain complex I assembly (GO:0032981)4.02276021
27NADH dehydrogenase complex assembly (GO:0010257)4.02276021
28mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.02276021
29DNA deamination (GO:0045006)3.98500491
30ubiquinone metabolic process (GO:0006743)3.96371331
31DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.94249614
32antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.93489264
33actin-myosin filament sliding (GO:0033275)3.91357389
34muscle filament sliding (GO:0030049)3.91357389
35carnitine shuttle (GO:0006853)3.87738141
36protein complex biogenesis (GO:0070271)3.86102072
37positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.85079492
382-oxoglutarate metabolic process (GO:0006103)3.84172812
39purine nucleotide salvage (GO:0032261)3.82430249
40cardiac myofibril assembly (GO:0055003)3.78888515
41signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.78731875
42intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.78731875
43chaperone-mediated protein transport (GO:0072321)3.78107647
44antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.77405345
45negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.76546990
46negative regulation of ligase activity (GO:0051352)3.76546990
47inner mitochondrial membrane organization (GO:0007007)3.74887912
48mitochondrial respiratory chain complex assembly (GO:0033108)3.74728137
49branched-chain amino acid catabolic process (GO:0009083)3.74082298
50signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.72932805
51signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.72932805
52signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.72932805
53ATP biosynthetic process (GO:0006754)3.71952670
54positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.68007433
55heart contraction (GO:0060047)3.66061470
56heart process (GO:0003015)3.66061470
57cardiac muscle contraction (GO:0060048)3.63559012
58regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.62231646
59signal transduction involved in DNA integrity checkpoint (GO:0072401)3.60668035
60signal transduction involved in DNA damage checkpoint (GO:0072422)3.60668035
61regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.55552163
62signal transduction involved in cell cycle checkpoint (GO:0072395)3.53500259
63regulation of relaxation of muscle (GO:1901077)3.51629571
64guanosine-containing compound biosynthetic process (GO:1901070)3.47753642
65energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.46071903
66ATP hydrolysis coupled proton transport (GO:0015991)3.46071903
67branched-chain amino acid metabolic process (GO:0009081)3.45926530
68valine metabolic process (GO:0006573)3.43092735
69regulation of mitochondrial translation (GO:0070129)3.40470745
70* tricarboxylic acid metabolic process (GO:0072350)3.40017940
71regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.35967328
72myofibril assembly (GO:0030239)3.35863339
73anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.35811575
74purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.35746199
75purine nucleoside monophosphate biosynthetic process (GO:0009127)3.35746199
76response to interferon-beta (GO:0035456)3.32631389
77pentose metabolic process (GO:0019321)3.31874416
78regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.31502920
79cellular respiration (GO:0045333)3.30942415
80regulation of oxidative phosphorylation (GO:0002082)3.30362638
81nucleotide salvage (GO:0043173)3.29470177
82positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.29402523
83fatty acid beta-oxidation (GO:0006635)3.28587304
84protein deneddylation (GO:0000338)3.27729206
85purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.27319548
86positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.26935637
87metallo-sulfur cluster assembly (GO:0031163)3.24706564
88iron-sulfur cluster assembly (GO:0016226)3.24706564
89regulation of skeletal muscle contraction (GO:0014819)3.23907056
90Golgi transport vesicle coating (GO:0048200)3.23170702
91COPI coating of Golgi vesicle (GO:0048205)3.23170702
92lysine catabolic process (GO:0006554)3.22373239
93lysine metabolic process (GO:0006553)3.22373239
94purine nucleoside triphosphate biosynthetic process (GO:0009145)3.21654877
95positive regulation of ligase activity (GO:0051351)3.20925179
96protein targeting to mitochondrion (GO:0006626)3.18792655
97regulation of cellular respiration (GO:0043457)3.17767252
98regulation of cellular amine metabolic process (GO:0033238)3.17711355
99formation of translation preinitiation complex (GO:0001731)3.17256378
100fatty acid transmembrane transport (GO:1902001)3.17015064
101ribonucleoside triphosphate biosynthetic process (GO:0009201)3.15433293
102L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.11551267
103respiratory chain complex IV assembly (GO:0008535)3.10175154
104proteasome assembly (GO:0043248)3.08606137
105regulation of actin filament-based movement (GO:1903115)3.06369721
106establishment of protein localization to mitochondrial membrane (GO:0090151)3.05701590
107daunorubicin metabolic process (GO:0044597)3.04956636
108polyketide metabolic process (GO:0030638)3.04956636
109doxorubicin metabolic process (GO:0044598)3.04956636
110nucleoside salvage (GO:0043174)3.02426696
111positive regulation of cell cycle arrest (GO:0071158)3.02012284
112antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.98043366
1132-deoxyribonucleotide biosynthetic process (GO:0009265)2.96733118
114deoxyribose phosphate biosynthetic process (GO:0046385)2.96733118
115establishment of protein localization to mitochondrion (GO:0072655)2.96134771
116mitochondrial transport (GO:0006839)2.94807537
117viral transcription (GO:0019083)2.93554995
118deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.92675493
119GTP biosynthetic process (GO:0006183)2.92200987
120pyrimidine-containing compound salvage (GO:0008655)2.92009074
121pyrimidine nucleoside salvage (GO:0043097)2.92009074
122carnitine transmembrane transport (GO:1902603)2.91744746
123mitochondrial calcium ion transport (GO:0006851)2.91331883
124cardiac muscle cell development (GO:0055013)2.91060481
125ribonucleoside monophosphate biosynthetic process (GO:0009156)2.90464491
126cytochrome complex assembly (GO:0017004)2.90121649
127actin-mediated cell contraction (GO:0070252)2.89516318
128translational elongation (GO:0006414)2.88697395
129aminoglycoside antibiotic metabolic process (GO:0030647)2.88670777
130biotin metabolic process (GO:0006768)2.87839879
131striated muscle contraction (GO:0006941)2.87615115
132pentose-phosphate shunt (GO:0006098)2.86343662
133NIK/NF-kappaB signaling (GO:0038061)2.85836477
134gluconeogenesis (GO:0006094)2.85754613
135negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.85354991
136translational termination (GO:0006415)2.84126887
137mitochondrial calcium ion homeostasis (GO:0051560)2.83856254
138DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.82523025
139galactose catabolic process (GO:0019388)2.81928023
140aspartate family amino acid catabolic process (GO:0009068)2.81885568
141amino-acid betaine transport (GO:0015838)2.80093711
142carnitine transport (GO:0015879)2.80093711
143nucleoside monophosphate biosynthetic process (GO:0009124)2.79646862
144regulation of ubiquitin-protein transferase activity (GO:0051438)2.79634167
145nucleoside triphosphate biosynthetic process (GO:0009142)2.78884763
146negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.78726130
147negative regulation of protein ubiquitination (GO:0031397)2.78123940
148protein localization to mitochondrion (GO:0070585)2.77588724
149mitotic nuclear envelope reassembly (GO:0007084)2.74883783
150nuclear envelope reassembly (GO:0031468)2.74883783
151Arp2/3 complex-mediated actin nucleation (GO:0034314)2.74838674
152regulation of ligase activity (GO:0051340)2.74750087
153hexose biosynthetic process (GO:0019319)2.74498217
154endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.74169189
155negative regulation of potassium ion transmembrane transport (GO:1901380)2.73843471
156hydrogen ion transmembrane transport (GO:1902600)2.73272332
157cellular response to interferon-beta (GO:0035458)2.73257676
158regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.72920725
159cullin deneddylation (GO:0010388)2.72817052
160regulation of sequestering of triglyceride (GO:0010889)2.72630471
161establishment of viral latency (GO:0019043)2.69358353
162regulation of cell cycle arrest (GO:0071156)2.67728994
163negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.66203014
164viral protein processing (GO:0019082)2.65941099
165GMP metabolic process (GO:0046037)2.65639344
166deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.65311478
167virion assembly (GO:0019068)2.64338031
168monosaccharide biosynthetic process (GO:0046364)2.62544335
169galactose metabolic process (GO:0006012)2.62104304
170lipopolysaccharide biosynthetic process (GO:0009103)2.61299558
171NADPH regeneration (GO:0006740)2.61093478
172UTP biosynthetic process (GO:0006228)2.60388973

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.75190038
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.20295056
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.02323945
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.79615178
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.73221358
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.69024547
7E2F7_22180533_ChIP-Seq_HELA_Human3.36688252
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.26823927
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.26399340
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.22848652
11GABP_17652178_ChIP-ChIP_JURKAT_Human3.17393017
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.16070535
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.96459570
14ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.82719414
15SRF_21415370_ChIP-Seq_HL-1_Mouse2.76374479
16* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.75566065
17THAP11_20581084_ChIP-Seq_MESCs_Mouse2.48617026
18TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.47202728
19* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.42960314
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.41288948
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.32174930
22VDR_23849224_ChIP-Seq_CD4+_Human2.30611668
23YY1_21170310_ChIP-Seq_MESCs_Mouse2.29670899
24CIITA_25753668_ChIP-Seq_RAJI_Human2.26953399
25* PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.26711367
26MYC_19079543_ChIP-ChIP_MESCs_Mouse2.26304256
27* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.22999439
28FOXP3_21729870_ChIP-Seq_TREG_Human2.18472341
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.05330287
30* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.03449496
31XRN2_22483619_ChIP-Seq_HELA_Human2.02972795
32TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.99890271
33GABP_19822575_ChIP-Seq_HepG2_Human1.99704720
34FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.98630786
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.98384646
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97485380
37DCP1A_22483619_ChIP-Seq_HELA_Human1.96179250
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.93848337
39NELFA_20434984_ChIP-Seq_ESCs_Mouse1.91385484
40ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.88262962
41NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.87204251
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.82455004
43BP1_19119308_ChIP-ChIP_Hs578T_Human1.75712604
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75464372
45* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.74099079
46LXR_22292898_ChIP-Seq_THP-1_Human1.72793780
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.68435365
48E2F4_17652178_ChIP-ChIP_JURKAT_Human1.66290884
49ERG_20887958_ChIP-Seq_HPC-7_Mouse1.64620830
50RARG_19884340_ChIP-ChIP_MEFs_Mouse1.64410515
51ELF1_20517297_ChIP-Seq_JURKAT_Human1.63883179
52TET1_21451524_ChIP-Seq_MESCs_Mouse1.63343877
53ZFX_18555785_ChIP-Seq_MESCs_Mouse1.60478536
54CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.54833160
55ELK3_25401928_ChIP-Seq_HUVEC_Human1.53604941
56TTF2_22483619_ChIP-Seq_HELA_Human1.52753719
57NANOG_18555785_ChIP-Seq_MESCs_Mouse1.47634672
58* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.45670602
59SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.44321784
60RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.43699525
61P68_20966046_ChIP-Seq_HELA_Human1.43325685
62FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.42831803
63GATA1_22025678_ChIP-Seq_K562_Human1.42516203
64CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.40493210
65POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.36350840
66* BCOR_27268052_Chip-Seq_Bcells_Human1.35559613
67MYC_22102868_ChIP-Seq_BL_Human1.34793092
68CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.32832345
69SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.31240066
70STAT3_1855785_ChIP-Seq_MESCs_Mouse1.30655479
71TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28078590
72RACK7_27058665_Chip-Seq_MCF-7_Human1.27869791
73CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.27809825
74MYCN_18555785_ChIP-Seq_MESCs_Mouse1.27555947
75KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.27389774
76CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.25651804
77MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.25219641
78NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.25091016
79GATA4_21415370_ChIP-Seq_HL-1_Mouse1.22549322
80SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.22539249
81ZNF263_19887448_ChIP-Seq_K562_Human1.21598083
82CTCF_26484167_Chip-Seq_Bcells_Mouse1.19529649
83CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.18572455
84STAT4_19710469_ChIP-ChIP_TH1__Mouse1.18125855
85CTCF_18555785_ChIP-Seq_MESCs_Mouse1.17730930
86LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.17698542
87PU.1_20513432_ChIP-Seq_Bcells_Mouse1.17634662
88SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.15082298
89GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.14677524
90SA1_27219007_Chip-Seq_ERYTHROID_Human1.14189045
91VDR_21846776_ChIP-Seq_THP-1_Human1.13846119
92MAF_26560356_Chip-Seq_TH2_Human1.13427395
93PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13104456
94SCL_19346495_ChIP-Seq_HPC-7_Human1.12805885
95HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.12781850
96FOXP1_21924763_ChIP-Seq_HESCs_Human1.10908048
97NOTCH1_21737748_ChIP-Seq_TLL_Human1.09082174
98PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.08698352
99CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08123629
100IRF8_21731497_ChIP-ChIP_J774_Mouse1.07948991
101POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.07768705
102SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07436042
103IRF8_22096565_ChIP-ChIP_GC-B_Human1.06546571
104ELK1_19687146_ChIP-ChIP_HELA_Human1.06309055
105SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05628022
106TBX5_21415370_ChIP-Seq_HL-1_Mouse1.05551960
107MAF_26560356_Chip-Seq_TH1_Human1.04053739
108MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.03242423
109EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.02889126
110YY1_22570637_ChIP-Seq_MALME-3M_Human1.02644172
111SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.01900693
112HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.01819009
113ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.01249171
114SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.01193191
115NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.01016259
116* BCL6_27268052_Chip-Seq_Bcells_Human0.97256971
117GATA1_22383799_ChIP-Seq_G1ME_Mouse0.96209660
118TFEB_21752829_ChIP-Seq_HELA_Human0.95859621
119MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.95516086
120KDM5A_27292631_Chip-Seq_BREAST_Human0.95396465
121MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.95326139
122DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.93688309
123E2F1_21310950_ChIP-Seq_MCF-7_Human0.93584521
124SPI1_23547873_ChIP-Seq_NB4_Human0.93395374
125POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.91977442
126MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.89211280
127LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.88527634
128RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86167081
129DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.85671058
130KLF4_18555785_ChIP-Seq_MESCs_Mouse0.85637128
131FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82830397
132SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.82235319
133SRY_22984422_ChIP-ChIP_TESTIS_Rat0.81353818
134ELK1_22589737_ChIP-Seq_MCF10A_Human0.81050765
135ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.79860976

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue5.69059287
2MP0002837_dystrophic_cardiac_calcinosis5.59233614
3MP0004084_abnormal_cardiac_muscle4.62661844
4MP0005058_abnormal_lysosome_morphology4.26012544
5MP0004215_abnormal_myocardial_fiber4.18637263
6MP0000751_myopathy4.17983425
7MP0006036_abnormal_mitochondrial_physio3.62466205
8MP0004036_abnormal_muscle_relaxation3.57167875
9MP0000749_muscle_degeneration3.50833770
10MP0008260_abnormal_autophagy3.45404825
11MP0005330_cardiomyopathy3.11571102
12MP0003191_abnormal_cellular_cholesterol2.88690311
13MP0004130_abnormal_muscle_cell2.66718032
14MP0009840_abnormal_foam_cell2.45803620
15MP0000750_abnormal_muscle_regeneration2.33953738
16MP0002132_abnormal_respiratory_system2.33313203
17MP0005670_abnormal_white_adipose2.31172037
18MP0006035_abnormal_mitochondrial_morpho2.29889500
19MP0008775_abnormal_heart_ventricle2.28430889
20MP0004087_abnormal_muscle_fiber2.26742877
21MP0002269_muscular_atrophy2.23830077
22MP0004147_increased_porphyrin_level2.23060022
23MP0005671_abnormal_response_to2.21856772
24MP0002972_abnormal_cardiac_muscle2.18160547
25MP0009333_abnormal_splenocyte_physiolog2.15667074
26MP0004145_abnormal_muscle_electrophysio2.15593238
27MP0002106_abnormal_muscle_physiology2.10706688
28MP0003221_abnormal_cardiomyocyte_apopto2.09437970
29MP0002148_abnormal_hypersensitivity_rea2.08769290
30MP0003137_abnormal_impulse_conducting2.08678159
31MP0004233_abnormal_muscle_weight2.08245031
32MP0005620_abnormal_muscle_contractility2.04332417
33MP0001544_abnormal_cardiovascular_syste2.03028950
34MP0005385_cardiovascular_system_phenoty2.03028950
35MP0009785_altered_susceptibility_to2.01227405
36MP0003786_premature_aging1.95761774
37MP0005451_abnormal_body_composition1.94116989
38MP0001835_abnormal_antigen_presentation1.92679043
39MP0003436_decreased_susceptibility_to1.91565471
40MP0000747_muscle_weakness1.86756616
41MP0001905_abnormal_dopamine_level1.81200107
42MP0002736_abnormal_nociception_after1.78647677
43MP0003075_altered_response_to1.77644031
44MP0010630_abnormal_cardiac_muscle1.75846260
45MP0005025_abnormal_response_to1.73437970
46MP0004484_altered_response_of1.73346154
47MP0002396_abnormal_hematopoietic_system1.69243792
48MP0006138_congestive_heart_failure1.67008166
49MP0000759_abnormal_skeletal_muscle1.63863321
50MP0005464_abnormal_platelet_physiology1.63537492
51MP0005666_abnormal_adipose_tissue1.63062213
52MP0005369_muscle_phenotype1.61435966
53MP0009278_abnormal_bone_marrow1.61358098
54MP0004510_myositis1.60541780
55MP0005000_abnormal_immune_tolerance1.58003627
56MP0006082_CNS_inflammation1.56990276
57MP0004043_abnormal_pH_regulation1.53080506
58MP0002332_abnormal_exercise_endurance1.51276981
59MP0003172_abnormal_lysosome_physiology1.46718315
60MP0003828_pulmonary_edema1.46652683
61MP0002419_abnormal_innate_immunity1.46157002
62MP0003693_abnormal_embryo_hatching1.43619556
63MP0002277_abnormal_respiratory_mucosa1.43408031
64MP0004085_abnormal_heartbeat1.41996187
65MP0002723_abnormal_immune_serum1.41977535
66MP0000372_irregular_coat_pigmentation1.39955485
67MP0005266_abnormal_metabolism1.36516008
68MP0003806_abnormal_nucleotide_metabolis1.27615774
69MP0004957_abnormal_blastocyst_morpholog1.25746807
70MP0002420_abnormal_adaptive_immunity1.24608065
71MP0001790_abnormal_immune_system1.24298568
72MP0005387_immune_system_phenotype1.24298568
73MP0003186_abnormal_redox_activity1.23440929
74MP0000685_abnormal_immune_system1.22612932
75MP0001819_abnormal_immune_cell1.22109446
76MP0001968_abnormal_touch/_nociception1.20772107
77MP0008469_abnormal_protein_level1.20089693
78MP0002127_abnormal_cardiovascular_syste1.19419429
79MP0002452_abnormal_antigen_presenting1.19120297
80MP0001845_abnormal_inflammatory_respons1.19064971
81MP0010030_abnormal_orbit_morphology1.17354248
82MP0001727_abnormal_embryo_implantation1.17346414
83MP0002909_abnormal_adrenal_gland1.16768246
84MP0003303_peritoneal_inflammation1.15290908
85MP0000858_altered_metastatic_potential1.13719306
86MP0000013_abnormal_adipose_tissue1.13446435
87MP0010094_abnormal_chromosome_stability1.12383196
88MP0001542_abnormal_bone_strength1.12132254
89MP0003656_abnormal_erythrocyte_physiolo1.12109807
90MP0005166_decreased_susceptibility_to1.08224801
91MP0008875_abnormal_xenobiotic_pharmacok1.08039137
92MP0000358_abnormal_cell_content/1.07409955
93MP0002822_catalepsy1.05456091
94MP0005375_adipose_tissue_phenotype1.04255079
95MP0000343_altered_response_to1.04056702
96MP0003567_abnormal_fetal_cardiomyocyte1.03358512
97MP0005319_abnormal_enzyme/_coenzyme1.02322191
98MP0001800_abnormal_humoral_immune0.97904555
99MP0001853_heart_inflammation0.97632301
100MP0008874_decreased_physiological_sensi0.97504335
101MP0002653_abnormal_ependyma_morphology0.97129529
102MP0002638_abnormal_pupillary_reflex0.96034765
103MP0002429_abnormal_blood_cell0.95618819
104MP0005584_abnormal_enzyme/coenzyme_acti0.94896694
105MP0002971_abnormal_brown_adipose0.93808878
106MP0000716_abnormal_immune_system0.93577896
107MP0009764_decreased_sensitivity_to0.93183173
108MP0005535_abnormal_body_temperature0.93069050
109MP0005084_abnormal_gallbladder_morpholo0.91485171
110MP0000230_abnormal_systemic_arterial0.91004616
111MP0005332_abnormal_amino_acid0.88985388
112MP0003111_abnormal_nucleus_morphology0.87923061
113MP0003077_abnormal_cell_cycle0.87318693
114MP0002078_abnormal_glucose_homeostasis0.86917646
115MP0003763_abnormal_thymus_physiology0.86361730
116MP0001533_abnormal_skeleton_physiology0.84970844
117MP0008058_abnormal_DNA_repair0.83193630
118MP0003724_increased_susceptibility_to0.80989728
119MP0001764_abnormal_homeostasis0.80342012
120MP0000703_abnormal_thymus_morphology0.79804385
121MP0001873_stomach_inflammation0.79381606
122MP0005165_increased_susceptibility_to0.79039956
123MP0004808_abnormal_hematopoietic_stem0.77778081
124MP0005410_abnormal_fertilization0.76013572
125MP0002970_abnormal_white_adipose0.75076595
126MP0008873_increased_physiological_sensi0.74304052
127MP0003045_fibrosis0.73975556
128MP0008789_abnormal_olfactory_epithelium0.73055391
129MP0000003_abnormal_adipose_tissue0.72708453
130MP0005075_abnormal_melanosome_morpholog0.72676993
131MP0000015_abnormal_ear_pigmentation0.72337024
132MP0002163_abnormal_gland_morphology0.72282370
133MP0000266_abnormal_heart_morphology0.72205354
134MP0002405_respiratory_system_inflammati0.70740133
135MP0005397_hematopoietic_system_phenotyp0.69350614
136MP0001545_abnormal_hematopoietic_system0.69350614
137MP0009763_increased_sensitivity_to0.68062634
138MP0010155_abnormal_intestine_physiology0.67551940
139MP0009643_abnormal_urine_homeostasis0.66840770
140MP0003879_abnormal_hair_cell0.66631612
141MP0005636_abnormal_mineral_homeostasis0.66100281
142MP0001529_abnormal_vocalization0.65557003
143MP0009697_abnormal_copulation0.64923751
144MP0001765_abnormal_ion_homeostasis0.61851825
145MP0005452_abnormal_adipose_tissue0.59692157
146MP0005376_homeostasis/metabolism_phenot0.58538198
147MP0008007_abnormal_cellular_replicative0.58249627
148MP0004142_abnormal_muscle_tone0.55753239
149MP0008872_abnormal_physiological_respon0.54024602
150MP0004185_abnormal_adipocyte_glucose0.51852692
151MP0002234_abnormal_pharynx_morphology0.51423081
152MP0005334_abnormal_fat_pad0.51194978
153MP0003123_paternal_imprinting0.50739344
154MP0009115_abnormal_fat_cell0.50710690
155MP0000313_abnormal_cell_death0.49962924
156MP0000490_abnormal_crypts_of0.49755075
157MP0003984_embryonic_growth_retardation0.46640617
158MP0003953_abnormal_hormone_level0.46595697
159MP0002722_abnormal_immune_system0.45576875
160MP0008569_lethality_at_weaning0.44250020
161MP0000689_abnormal_spleen_morphology0.43859502
162MP0002080_prenatal_lethality0.43458548
163MP0001756_abnormal_urination0.42836910
164MP0002398_abnormal_bone_marrow0.42367938
165MP0003866_abnormal_defecation0.42210730
166MP0002088_abnormal_embryonic_growth/wei0.42105178

Predicted human phenotypes

RankGene SetZ-score
1Hepatic necrosis (HP:0002605)5.36307013
2Hepatocellular necrosis (HP:0001404)5.10665853
3Abnormal mitochondria in muscle tissue (HP:0008316)5.04483370
4Acute necrotizing encephalopathy (HP:0006965)4.88748298
5Myoglobinuria (HP:0002913)4.72163621
6Mitochondrial inheritance (HP:0001427)4.56286979
7Exercise-induced myalgia (HP:0003738)4.43676756
8Increased CSF lactate (HP:0002490)4.38483460
9Acute encephalopathy (HP:0006846)4.35701714
10Sudden death (HP:0001699)4.26998676
11Hyperalaninemia (HP:0003348)4.23333403
12Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.23333403
13Abnormality of alanine metabolism (HP:0010916)4.23333403
14Rhabdomyolysis (HP:0003201)4.09261153
15Increased muscle lipid content (HP:0009058)4.07472814
16Exercise-induced muscle cramps (HP:0003710)4.07324037
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.93751169
18Decreased activity of mitochondrial respiratory chain (HP:0008972)3.93751169
19Progressive macrocephaly (HP:0004481)3.92690837
20Lactic acidosis (HP:0003128)3.89000242
21Ventricular tachycardia (HP:0004756)3.84758133
22Palpitations (HP:0001962)3.83923919
23Abnormal gallbladder physiology (HP:0012438)3.75722014
24Cholecystitis (HP:0001082)3.75722014
25Calf muscle hypertrophy (HP:0008981)3.70159104
26Increased intramyocellular lipid droplets (HP:0012240)3.68510656
27Abnormality of fatty-acid metabolism (HP:0004359)3.62846327
28Dicarboxylic aciduria (HP:0003215)3.53237614
29Abnormality of dicarboxylic acid metabolism (HP:0010995)3.53237614
30Petechiae (HP:0000967)3.45615116
31Exercise intolerance (HP:0003546)3.45452320
32Increased serum lactate (HP:0002151)3.43451492
33Muscle hypertrophy of the lower extremities (HP:0008968)3.41050922
34Generalized aminoaciduria (HP:0002909)3.36589196
35Ragged-red muscle fibers (HP:0003200)3.34576550
36Cerebral edema (HP:0002181)3.33101308
37Lipoatrophy (HP:0100578)3.27763862
38Respiratory failure (HP:0002878)3.25154612
39Abnormality of the left ventricular outflow tract (HP:0011103)3.20430107
40Subaortic stenosis (HP:0001682)3.20430107
41Hypokinesia (HP:0002375)3.19297106
42Increased serum pyruvate (HP:0003542)3.16641526
43Abnormality of glycolysis (HP:0004366)3.16641526
44Abnormality of liposaccharide metabolism (HP:0010968)3.15954219
45Abnormality of glycosphingolipid metabolism (HP:0004343)3.15954219
46Abnormality of glycolipid metabolism (HP:0010969)3.15954219
47Atrial fibrillation (HP:0005110)3.14981920
48Supraventricular tachycardia (HP:0004755)3.09289597
49Renal Fanconi syndrome (HP:0001994)3.09161553
50Prolonged neonatal jaundice (HP:0006579)3.06427764
51Lipid accumulation in hepatocytes (HP:0006561)3.03225524
52Supraventricular arrhythmia (HP:0005115)2.98773715
53Primary atrial arrhythmia (HP:0001692)2.97082387
54Muscle fiber splitting (HP:0003555)2.95015033
55Ketoacidosis (HP:0001993)2.89151395
56Dilated cardiomyopathy (HP:0001644)2.86222532
57Type I transferrin isoform profile (HP:0003642)2.84883507
58Abnormality of the calf musculature (HP:0001430)2.84099786
59Hyperglycinuria (HP:0003108)2.82822434
60Hypoglycemic coma (HP:0001325)2.81983928
61Elevated erythrocyte sedimentation rate (HP:0003565)2.81662438
62Bundle branch block (HP:0011710)2.72092144
63Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.69631861
64Increased hepatocellular lipid droplets (HP:0006565)2.63912505
65Hepatosplenomegaly (HP:0001433)2.63673375
66Myotonia (HP:0002486)2.61831193
67Esophageal neoplasm (HP:0100751)2.61187891
68Neoplasm of head and neck (HP:0012288)2.61187891
69Asymmetric septal hypertrophy (HP:0001670)2.56568476
70Neuroendocrine neoplasm (HP:0100634)2.55333938
71Distal lower limb muscle weakness (HP:0009053)2.54504415
72Rough bone trabeculation (HP:0100670)2.51034922
73Vertebral compression fractures (HP:0002953)2.49517960
74Progressive neurologic deterioration (HP:0002344)2.46856115
75Myopathic facies (HP:0002058)2.46721566
76Pheochromocytoma (HP:0002666)2.46713365
77CNS demyelination (HP:0007305)2.46708050
78Microretrognathia (HP:0000308)2.46349667
79Neoplasm of the adrenal gland (HP:0100631)2.43604925
80Emotional lability (HP:0000712)2.41854988
81Syncope (HP:0001279)2.41803045
82Loss of speech (HP:0002371)2.41535333
83Lethargy (HP:0001254)2.41086079
84Progressive muscle weakness (HP:0003323)2.38496650
85Abnormality of macrophages (HP:0004311)2.36817877
86Progressive microcephaly (HP:0000253)2.35938674
87Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.35826264
88Abnormal number of erythroid precursors (HP:0012131)2.32006812
89Opisthotonus (HP:0002179)2.31634611
90Conjunctival hamartoma (HP:0100780)2.31613958
91Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.30488155
92EMG: myopathic abnormalities (HP:0003458)2.30456594
93Heart block (HP:0012722)2.30443845
943-Methylglutaconic aciduria (HP:0003535)2.29448717
95Atrioventricular block (HP:0001678)2.28985151
96Nausea (HP:0002018)2.26970051
97Abnormality of cells of the erythroid lineage (HP:0012130)2.26927229
98Hypertensive crisis (HP:0100735)2.25097936
99Methylmalonic aciduria (HP:0012120)2.24017157
100Multiple enchondromatosis (HP:0005701)2.23642429
101Ketosis (HP:0001946)2.22615790
102Tinnitus (HP:0000360)2.22127534
103Aplastic anemia (HP:0001915)2.22122215
104Cerebral hypomyelination (HP:0006808)2.21264538
105Prolonged QT interval (HP:0001657)2.20763496
106Hyperammonemia (HP:0001987)2.20492835
107Abnormality of glycine metabolism (HP:0010895)2.19304602
108Abnormality of serine family amino acid metabolism (HP:0010894)2.19304602
109Muscle stiffness (HP:0003552)2.19270212
110Optic disc pallor (HP:0000543)2.18962708
111Purpura (HP:0000979)2.17782828
112Respiratory difficulties (HP:0002880)2.17627504
113Cerebral palsy (HP:0100021)2.17476675
114Proximal tubulopathy (HP:0000114)2.17313540
115Ventricular arrhythmia (HP:0004308)2.16858375
116Axonal loss (HP:0003447)2.15915187
117Dysostosis multiplex (HP:0000943)2.13744390
118Testicular atrophy (HP:0000029)2.12303673
119Cholelithiasis (HP:0001081)2.09658089
120Ventricular fibrillation (HP:0001663)2.09467624
121J-shaped sella turcica (HP:0002680)2.09125752
122Reduced subcutaneous adipose tissue (HP:0003758)2.08796404
123Exertional dyspnea (HP:0002875)2.07266264
124Unsteady gait (HP:0002317)2.07080394
125Microvesicular hepatic steatosis (HP:0001414)2.06957587
126Metabolic acidosis (HP:0001942)2.06263788
127Nuclear cataract (HP:0100018)2.06026617
128Abnormal atrioventricular conduction (HP:0005150)2.05115757
129Degeneration of anterior horn cells (HP:0002398)2.04625702
130Abnormality of the anterior horn cell (HP:0006802)2.04625702
131Systemic lupus erythematosus (HP:0002725)2.04345902
132Abnormal glycosylation (HP:0012345)2.02899669
133Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.02899669
134Abnormal protein N-linked glycosylation (HP:0012347)2.02899669
135Abnormal protein glycosylation (HP:0012346)2.02899669
136Gliosis (HP:0002171)2.02112119
137Left ventricular hypertrophy (HP:0001712)2.01202080
138Increased connective tissue (HP:0009025)2.00629902
139Vomiting (HP:0002013)2.00173580
140Distal lower limb amyotrophy (HP:0008944)1.98332129
141Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.97713437
142Areflexia of lower limbs (HP:0002522)1.97303666
143Vacuolated lymphocytes (HP:0001922)1.92992837
144Limb-girdle muscle atrophy (HP:0003797)1.92498798
145Recurrent abscess formation (HP:0002722)1.91855584
146Increased serum ferritin (HP:0003281)1.89304977
147Reduced antithrombin III activity (HP:0001976)1.87097981
148Abnormality of lateral ventricle (HP:0030047)1.86849197
149Chronic obstructive pulmonary disease (HP:0006510)1.86407560
150Obstructive lung disease (HP:0006536)1.86407560
151Gastrointestinal dysmotility (HP:0002579)1.86401833
152Mutism (HP:0002300)1.85787390
153Increased IgM level (HP:0003496)1.84402739
154Tongue fasciculations (HP:0001308)1.82971248
155Abnormal pupillary function (HP:0007686)1.82703156
156Abnormal trabecular bone morphology (HP:0100671)1.81651102
157Abnormality of polysaccharide metabolism (HP:0011012)1.81356468
158Abnormality of glycosaminoglycan metabolism (HP:0004371)1.81356468
159Abnormality of mucopolysaccharide metabolism (HP:0011020)1.81356468
160Upper limb muscle weakness (HP:0003484)1.78493878
161Abnormal gallbladder morphology (HP:0012437)1.75122589

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.91583576
2TESK14.35459991
3VRK23.96431420
4TESK23.85999250
5NEK13.81715532
6PDK43.49617238
7PDK33.49617238
8MYLK2.97455180
9OBSCN2.87469967
10TTN2.79885635
11FLT32.74629330
12LIMK12.66308428
13PHKG12.43297486
14PHKG22.43297486
15NME22.41194178
16WEE12.35227044
17STK162.34310997
18BUB12.27849993
19LMTK22.07760003
20PKN22.00794056
21EIF2AK11.98269365
22PINK11.96009281
23SIK31.95815574
24ERN11.93266459
25NME11.81689637
26PDK21.78223207
27MAP3K121.77834567
28MUSK1.75653270
29TSSK61.64603626
30MAP3K31.64103408
31BRSK21.57807789
32TRIB31.54047441
33CCNB11.51303328
34MAPKAPK31.49750560
35TIE11.45910133
36MAP2K31.42062561
37TBK11.41001748
38KIT1.37061161
39EPHA21.26244830
40TGFBR11.22884347
41RIPK41.22224886
42DAPK11.19135992
43KDR1.17855050
44ABL21.09645600
45SMG11.07618280
46IRAK41.06810656
47CSNK1G31.05260054
48SIK11.04711595
49GRK71.03441370
50CDK191.02643622
51VRK11.02488569
52EIF2AK31.02371853
53MAP4K21.02328682
54RPS6KB21.02326110
55PIK3CA0.99641002
56ILK0.99584933
57BRSK10.97468123
58ACVR1B0.95400617
59CAMK10.93745780
60MAP3K110.93722518
61ZAK0.89022599
62MST40.87784211
63TNK20.87614721
64MAP4K10.86064907
65PIM20.83987314
66PAK10.83934807
67CAMK2G0.83832166
68TAOK20.83053617
69STK240.82462256
70CAMKK20.82330615
71TRIM280.82282249
72PIK3CG0.80384769
73MAP2K60.78250960
74TYK20.78149609
75SRPK10.77153326
76IKBKB0.77142005
77PRKD30.74659410
78DYRK30.74105704
79TAOK10.72173337
80SCYL20.70211407
81BTK0.69582100
82PRKCI0.68331686
83MST1R0.67036821
84MAPK120.66197969
85CSNK1A1L0.65649494
86TEC0.63996793
87PBK0.63714350
88IKBKE0.62649075
89BRAF0.61239000
90PRPF4B0.61087471
91EPHB10.58945946
92PAK60.58839352
93MINK10.58500641
94CSNK1G20.57958446
95LRRK20.56397721
96AURKB0.56238255
97TXK0.55711544
98CAMK2D0.54740597
99RPS6KC10.53905870
100RPS6KL10.53905870
101GRK50.53291017
102CDK80.52726522
103SIK20.52613449
104DAPK30.50372556
105CSF1R0.50197921
106SYK0.49505392
107FES0.48293873
108STK40.48141927
109ZAP700.47422495
110CDC70.46790475
111CDK140.46371502
112PLK10.45514932
113IRAK30.45493957
114RPS6KA60.45277280
115TLK10.45155730
116AKT20.45051470
117PRKAA10.44396837
118IRAK20.44177229
119MAPK110.43807651
120MAP3K50.42919844
121MAPKAPK20.42186368
122ATR0.41331287
123CAMK40.39514969
124CSNK1G10.39141967
125CDK11A0.38804780
126CDK40.38665027
127CDK180.38457347
128MAP3K80.36430938
129DAPK20.36336143
130TGFBR20.35828631
131CDK150.35300799
132MAP2K70.35049798
133PASK0.34473634
134CSNK2A10.33944374
135PDPK10.33428747
136MAP3K70.33258630
137BLK0.32823567
138WNK30.32509372
139CSNK2A20.32239769
140PRKG20.31735479
141PRKACA0.31271472
142CAMK2B0.31164034
143TNIK0.31155649
144EEF2K0.30140520
145PRKACB0.29932399
146MAPK40.29823278
147PRKD10.29717686
148ARAF0.29522149
149AURKA0.28425579
150NEK20.27840336
151CAMKK10.27546033
152PAK40.26873704
153PRKAA20.25769625
154MAP2K40.25294857
155GRK60.23470328

Predicted pathways (KEGG)

RankGene SetZ-score
1* Citrate cycle (TCA cycle)_Homo sapiens_hsa000206.39554946
2Oxidative phosphorylation_Homo sapiens_hsa001903.89747208
3* 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.84579546
4Parkinsons disease_Homo sapiens_hsa050123.75740700
5Propanoate metabolism_Homo sapiens_hsa006403.05859590
6Proteasome_Homo sapiens_hsa030502.75478643
7Cardiac muscle contraction_Homo sapiens_hsa042602.75105921
8* Carbon metabolism_Homo sapiens_hsa012002.69125039
9Ribosome_Homo sapiens_hsa030102.59447274
10Huntingtons disease_Homo sapiens_hsa050162.54772089
11Alzheimers disease_Homo sapiens_hsa050102.49184484
12Pyruvate metabolism_Homo sapiens_hsa006202.35935547
13DNA replication_Homo sapiens_hsa030302.34027571
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.28109775
15Fatty acid degradation_Homo sapiens_hsa000712.25996056
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.08429380
17Mismatch repair_Homo sapiens_hsa034301.93698454
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.87934305
19RNA polymerase_Homo sapiens_hsa030201.71259326
20Glycosaminoglycan degradation_Homo sapiens_hsa005311.70872605
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.69455809
22Fatty acid metabolism_Homo sapiens_hsa012121.67219961
23Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.57054939
24Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.56893921
25SNARE interactions in vesicular transport_Homo sapiens_hsa041301.53635769
26* Biosynthesis of amino acids_Homo sapiens_hsa012301.50229183
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.40240847
28Lysosome_Homo sapiens_hsa041421.39987082
29Pyrimidine metabolism_Homo sapiens_hsa002401.39795823
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.38680099
31Rheumatoid arthritis_Homo sapiens_hsa053231.32813768
32Base excision repair_Homo sapiens_hsa034101.32789615
33Fructose and mannose metabolism_Homo sapiens_hsa000511.26191946
34Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.19170735
35Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.17206305
36Pentose phosphate pathway_Homo sapiens_hsa000301.17094336
37Antigen processing and presentation_Homo sapiens_hsa046121.13980489
38Dilated cardiomyopathy_Homo sapiens_hsa054141.13280372
39Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.12543558
40Homologous recombination_Homo sapiens_hsa034401.07854271
41Nucleotide excision repair_Homo sapiens_hsa034201.07580855
42Sulfur metabolism_Homo sapiens_hsa009201.07470958
43Spliceosome_Homo sapiens_hsa030401.06646955
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.04991169
45Galactose metabolism_Homo sapiens_hsa000521.00531804
46Purine metabolism_Homo sapiens_hsa002300.99793799
47Allograft rejection_Homo sapiens_hsa053300.93078254
48Fatty acid elongation_Homo sapiens_hsa000620.91312815
49Sulfur relay system_Homo sapiens_hsa041220.88610494
50Shigellosis_Homo sapiens_hsa051310.87819255
51beta-Alanine metabolism_Homo sapiens_hsa004100.86489351
52Asthma_Homo sapiens_hsa053100.85472924
53Butanoate metabolism_Homo sapiens_hsa006500.85401016
54RNA transport_Homo sapiens_hsa030130.84716004
55Autoimmune thyroid disease_Homo sapiens_hsa053200.80378509
56RNA degradation_Homo sapiens_hsa030180.79917856
57Peroxisome_Homo sapiens_hsa041460.77210321
58Salmonella infection_Homo sapiens_hsa051320.75455365
59Graft-versus-host disease_Homo sapiens_hsa053320.74538707
60Phagosome_Homo sapiens_hsa041450.72593979
61* Metabolic pathways_Homo sapiens_hsa011000.72172773
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70220026
63Folate biosynthesis_Homo sapiens_hsa007900.68598527
64Protein export_Homo sapiens_hsa030600.66761509
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62506695
66Cyanoamino acid metabolism_Homo sapiens_hsa004600.60027601
67Tuberculosis_Homo sapiens_hsa051520.59925777
68Glucagon signaling pathway_Homo sapiens_hsa049220.59010193
69PPAR signaling pathway_Homo sapiens_hsa033200.58565557
70Collecting duct acid secretion_Homo sapiens_hsa049660.57446397
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56807400
72Intestinal immune network for IgA production_Homo sapiens_hsa046720.56682040
73Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56344526
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52999908
75Non-homologous end-joining_Homo sapiens_hsa034500.52238641
76Type I diabetes mellitus_Homo sapiens_hsa049400.51902929
77Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.47188023
78Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46083366
79Insulin signaling pathway_Homo sapiens_hsa049100.42995223
80Toll-like receptor signaling pathway_Homo sapiens_hsa046200.41404459
81Pertussis_Homo sapiens_hsa051330.41400083
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40329469
83Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39863665
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.39552689
85Circadian rhythm_Homo sapiens_hsa047100.39314615
86Regulation of autophagy_Homo sapiens_hsa041400.39218611
87Starch and sucrose metabolism_Homo sapiens_hsa005000.38557279
88Endocytosis_Homo sapiens_hsa041440.38478815
89Leishmaniasis_Homo sapiens_hsa051400.36251104
90Arginine and proline metabolism_Homo sapiens_hsa003300.35445640
91Cell cycle_Homo sapiens_hsa041100.34733552
92RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.34433169
93HIF-1 signaling pathway_Homo sapiens_hsa040660.33988770
94Tyrosine metabolism_Homo sapiens_hsa003500.33189975
95Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.32342061
96One carbon pool by folate_Homo sapiens_hsa006700.32101734
97Glutathione metabolism_Homo sapiens_hsa004800.31892892
98Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.30432155
99AMPK signaling pathway_Homo sapiens_hsa041520.29325504
100Calcium signaling pathway_Homo sapiens_hsa040200.29263730
101Drug metabolism - other enzymes_Homo sapiens_hsa009830.27860193
102Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.27074406
103Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.25183701
104Insulin resistance_Homo sapiens_hsa049310.24903743
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.24203813
106Phenylalanine metabolism_Homo sapiens_hsa003600.23325341
107Tryptophan metabolism_Homo sapiens_hsa003800.23306976
108Apoptosis_Homo sapiens_hsa042100.23156304
109Caffeine metabolism_Homo sapiens_hsa002320.22912068
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.22380880
111Vitamin B6 metabolism_Homo sapiens_hsa007500.21969414
112Legionellosis_Homo sapiens_hsa051340.21872886
113Vibrio cholerae infection_Homo sapiens_hsa051100.21743269
114Osteoclast differentiation_Homo sapiens_hsa043800.21703062
115Primary immunodeficiency_Homo sapiens_hsa053400.21647512
116Viral myocarditis_Homo sapiens_hsa054160.20668447
117Epstein-Barr virus infection_Homo sapiens_hsa051690.20098991
118Staphylococcus aureus infection_Homo sapiens_hsa051500.17367940
119Herpes simplex infection_Homo sapiens_hsa051680.17085959
120Glycerolipid metabolism_Homo sapiens_hsa005610.16500425
121Fanconi anemia pathway_Homo sapiens_hsa034600.16084732
122Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.15971314
123NF-kappa B signaling pathway_Homo sapiens_hsa040640.15007417
124Basal transcription factors_Homo sapiens_hsa030220.14891825
125Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.14828416
126Synaptic vesicle cycle_Homo sapiens_hsa047210.14038973
127Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.13643462
128N-Glycan biosynthesis_Homo sapiens_hsa005100.13623996
129Other glycan degradation_Homo sapiens_hsa005110.13519753
130cGMP-PKG signaling pathway_Homo sapiens_hsa040220.12902243
131Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.09584529
132Thyroid cancer_Homo sapiens_hsa052160.08695608
133Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.07691674
134Fatty acid biosynthesis_Homo sapiens_hsa000610.06922238
135Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.06893804
136Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.06668166

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