IDI1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: IDI1 encodes a peroxisomally-localized enzyme that catalyzes the interconversion of isopentenyl diphosphate (IPP) to its highly electrophilic isomer, dimethylallyl diphosphate (DMAPP), which are the substrates for the successive reaction that results in the synthesis of farnesyl diphosphate and, ultimately, cholesterol. It has been shown in peroxisomal deficiency diseases such as Zellweger syndrome and neonatal adrenoleukodystrophy that there is reduction in IPP isomerase activity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)9.77878888
2central nervous system myelination (GO:0022010)9.77878888
3* cholesterol biosynthetic process (GO:0006695)9.18545694
4* sterol biosynthetic process (GO:0016126)8.13313448
5long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)6.26448237
6* isoprenoid biosynthetic process (GO:0008299)6.03223927
7long-chain fatty acid biosynthetic process (GO:0042759)5.78644845
8fatty-acyl-CoA biosynthetic process (GO:0046949)5.69173770
9axon ensheathment (GO:0008366)5.61596900
10ensheathment of neurons (GO:0007272)5.61596900
11myelination (GO:0042552)5.58108874
12long-chain fatty-acyl-CoA metabolic process (GO:0035336)5.53394101
13L-phenylalanine catabolic process (GO:0006559)5.05468327
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.05468327
15fatty-acyl-CoA metabolic process (GO:0035337)5.04006255
16response to lipoprotein particle (GO:0055094)4.92285554
17very long-chain fatty acid metabolic process (GO:0000038)4.82746790
18thioester biosynthetic process (GO:0035384)4.68769628
19acyl-CoA biosynthetic process (GO:0071616)4.68769628
20response to methylmercury (GO:0051597)4.55267905
21amyloid precursor protein metabolic process (GO:0042982)4.54995315
22L-phenylalanine metabolic process (GO:0006558)4.30318289
23erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.30318289
24myelin maintenance (GO:0043217)4.26206242
25* cholesterol metabolic process (GO:0008203)4.15904016
26* steroid biosynthetic process (GO:0006694)4.01799904
27amyloid precursor protein catabolic process (GO:0042987)3.99619278
28glycerophospholipid catabolic process (GO:0046475)3.97913223
29acyl-CoA metabolic process (GO:0006637)3.93436901
30thioester metabolic process (GO:0035383)3.93436901
31negative regulation of neurotransmitter secretion (GO:0046929)3.92138371
32* sterol metabolic process (GO:0016125)3.84932326
33DNA double-strand break processing (GO:0000729)3.81210771
34regulation of collateral sprouting (GO:0048670)3.79028594
35acetyl-CoA metabolic process (GO:0006084)3.77586972
36regulation of lipoprotein metabolic process (GO:0050746)3.75278332
37* alcohol biosynthetic process (GO:0046165)3.73729460
38negative regulation of neurotransmitter transport (GO:0051589)3.71367487
39response to follicle-stimulating hormone (GO:0032354)3.70775712
40creatine metabolic process (GO:0006600)3.67919326
41ubiquinone metabolic process (GO:0006743)3.67723464
42establishment of mitochondrion localization (GO:0051654)3.59436172
43aromatic amino acid family catabolic process (GO:0009074)3.59342762
44cullin deneddylation (GO:0010388)3.55216208
45heme transport (GO:0015886)3.49820933
46pyrimidine nucleobase catabolic process (GO:0006208)3.47837186
47positive regulation of cellular amine metabolic process (GO:0033240)3.46902234
48cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.42587766
49terpenoid biosynthetic process (GO:0016114)3.38088310
50glyoxylate metabolic process (GO:0046487)3.37933434
51coenzyme catabolic process (GO:0009109)3.36286554
52substantia nigra development (GO:0021762)3.35638748
53nucleotide transmembrane transport (GO:1901679)3.33287780
54L-serine metabolic process (GO:0006563)3.32361924
55cofactor catabolic process (GO:0051187)3.31625860
56regulation of activation of Janus kinase activity (GO:0010533)3.31384063
57alpha-linolenic acid metabolic process (GO:0036109)3.30628905
58oligodendrocyte differentiation (GO:0048709)3.28480111
59protein neddylation (GO:0045116)3.27721055
60response to redox state (GO:0051775)3.27542203
61cellular response to cholesterol (GO:0071397)3.22838224
62intraciliary transport (GO:0042073)3.21560866
63negative regulation of protein localization to cell surface (GO:2000009)3.21549899
64aldehyde catabolic process (GO:0046185)3.19729144
65positive regulation of mitochondrial fission (GO:0090141)3.19254435
66positive regulation of oligodendrocyte differentiation (GO:0048714)3.19136132
67eye photoreceptor cell differentiation (GO:0001754)3.15938491
68photoreceptor cell differentiation (GO:0046530)3.15938491
69protein deneddylation (GO:0000338)3.12400167
70bile acid biosynthetic process (GO:0006699)3.10791852
71positive regulation of pseudopodium assembly (GO:0031274)3.09257443
72import into cell (GO:0098657)3.07649141
73estrogen biosynthetic process (GO:0006703)3.06298186
74nucleobase catabolic process (GO:0046113)3.05915482
75positive regulation of interleukin-17 production (GO:0032740)3.04264391
76triglyceride biosynthetic process (GO:0019432)3.00603597
77apical protein localization (GO:0045176)2.98128538
78presynaptic membrane assembly (GO:0097105)2.92764195
79L-amino acid import (GO:0043092)2.91989774
80nonmotile primary cilium assembly (GO:0035058)2.91696588
81DNA damage response, detection of DNA damage (GO:0042769)2.89592262
82neutral lipid biosynthetic process (GO:0046460)2.89164554
83acylglycerol biosynthetic process (GO:0046463)2.89164554
84positive regulation of actin filament depolymerization (GO:0030836)2.88706890
85regulation of development, heterochronic (GO:0040034)2.86633543
86iron coordination entity transport (GO:1901678)2.86475432
87asymmetric protein localization (GO:0008105)2.86006368
88regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.84147901
89tyrosine metabolic process (GO:0006570)2.83668811
90regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.83619056
91glutathione derivative metabolic process (GO:1901685)2.80758473
92glutathione derivative biosynthetic process (GO:1901687)2.80758473
93* organic hydroxy compound biosynthetic process (GO:1901617)2.80262262
94fatty acid biosynthetic process (GO:0006633)2.80004330
95limb bud formation (GO:0060174)2.79999335
96proteasome assembly (GO:0043248)2.79831782
97lipid particle organization (GO:0034389)2.77600260
98regulation of cholesterol biosynthetic process (GO:0045540)2.77022961
99astrocyte development (GO:0014002)2.75202045
100axon development (GO:0061564)2.75178084
101regulation of memory T cell differentiation (GO:0043380)2.70741261
102regulation of timing of cell differentiation (GO:0048505)2.69043505
103coenzyme A metabolic process (GO:0015936)2.68362272
104virion attachment to host cell (GO:0019062)2.68208508
105adhesion of symbiont to host cell (GO:0044650)2.68208508
106pyrimidine-containing compound transmembrane transport (GO:0072531)2.66208368
107serine family amino acid biosynthetic process (GO:0009070)2.64120565
108very-low-density lipoprotein particle assembly (GO:0034379)2.63067547
109water-soluble vitamin biosynthetic process (GO:0042364)2.63014193
110peripheral nervous system axon ensheathment (GO:0032292)2.62932019
111myelination in peripheral nervous system (GO:0022011)2.62932019
112ethanol oxidation (GO:0006069)2.62147943
113plasma lipoprotein particle clearance (GO:0034381)2.62021252
114cellular response to gonadotropin stimulus (GO:0071371)2.61311116
115regulation of pseudopodium assembly (GO:0031272)2.60413891
116GPI anchor metabolic process (GO:0006505)2.60357012
117response to cholesterol (GO:0070723)2.60354783
118negative regulation of DNA recombination (GO:0045910)2.60104764
119* steroid metabolic process (GO:0008202)2.59947356
120regulation of coenzyme metabolic process (GO:0051196)2.59861630
121regulation of cofactor metabolic process (GO:0051193)2.59861630
122C4-dicarboxylate transport (GO:0015740)2.57897249
123serine family amino acid catabolic process (GO:0009071)2.56333819
124L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.55467415
125cilium morphogenesis (GO:0060271)2.55337602
126protein-cofactor linkage (GO:0018065)2.52103694
127epithelial cilium movement (GO:0003351)2.51693039
128protein localization to cilium (GO:0061512)2.51330785
129sequestering of actin monomers (GO:0042989)2.51188950
130peroxisome fission (GO:0016559)2.50649250
131presynaptic membrane organization (GO:0097090)2.50539404
132histone H2A acetylation (GO:0043968)2.49968076
133regulation of acyl-CoA biosynthetic process (GO:0050812)2.49318410
134quinone metabolic process (GO:1901661)2.48993542
135organelle disassembly (GO:1903008)2.48766040
136ubiquinone biosynthetic process (GO:0006744)2.48059003
137cysteine metabolic process (GO:0006534)2.47665241
138establishment of protein localization to mitochondrial membrane (GO:0090151)2.47555896
139amino acid salvage (GO:0043102)2.47410884
140L-methionine salvage (GO:0071267)2.47410884
141L-methionine biosynthetic process (GO:0071265)2.47410884
142branched-chain amino acid catabolic process (GO:0009083)2.44709356
143mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.43454123
144peptidyl-cysteine modification (GO:0018198)2.43256267
145resolution of meiotic recombination intermediates (GO:0000712)2.41163561
146chromatin remodeling at centromere (GO:0031055)2.41131973
147regulation of hexokinase activity (GO:1903299)2.40991276
148regulation of glucokinase activity (GO:0033131)2.40991276
149neural tube formation (GO:0001841)2.39601028
150serine family amino acid metabolic process (GO:0009069)2.37873615
151neuron fate determination (GO:0048664)2.37715626
152CENP-A containing nucleosome assembly (GO:0034080)2.37605103
153response to nitrosative stress (GO:0051409)2.37202158
154peroxisome organization (GO:0007031)2.36137955
155negative regulation of transcription regulatory region DNA binding (GO:2000678)2.35068185
156nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.31425256
157ribonucleoprotein complex disassembly (GO:0032988)2.30954061
158olfactory bulb development (GO:0021772)2.30612456
159chaperone-mediated protein transport (GO:0072321)2.30062809
160forebrain neuron differentiation (GO:0021879)2.29383228
161neuron cell-cell adhesion (GO:0007158)2.28903387
162mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.28473905
163mitochondrial respiratory chain complex I assembly (GO:0032981)2.28473905
164NADH dehydrogenase complex assembly (GO:0010257)2.28473905
165DNA ligation (GO:0006266)2.25776924
166negative regulation of oligodendrocyte differentiation (GO:0048715)2.25258214
167peptidyl-histidine modification (GO:0018202)2.24963941
168tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.23843486
169RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.23843486
170quinone biosynthetic process (GO:1901663)2.23246542
171glycosphingolipid biosynthetic process (GO:0006688)2.23027148
172negative regulation of astrocyte differentiation (GO:0048712)2.22956961
173exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.22263183
174spermatid nucleus differentiation (GO:0007289)2.21827675
175cellular response to sterol (GO:0036315)2.20137684
176neuronal action potential propagation (GO:0019227)2.19885745
177purine nucleobase biosynthetic process (GO:0009113)2.19391090
178DNA catabolic process, exonucleolytic (GO:0000738)2.19315694
179regulation of sulfur metabolic process (GO:0042762)2.19097011
180fatty acid elongation (GO:0030497)10.1008160

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.33562133
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.20885107
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.45138909
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.39566880
5EGR1_23403033_ChIP-Seq_LIVER_Mouse3.30002302
6SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.88713513
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.86902645
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.84748768
9RXR_22158963_ChIP-Seq_LIVER_Mouse2.75969816
10IGF1R_20145208_ChIP-Seq_DFB_Human2.66691163
11LXR_22158963_ChIP-Seq_LIVER_Mouse2.61547249
12ZNF274_21170338_ChIP-Seq_K562_Hela2.60515812
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.57161929
14ELK1_19687146_ChIP-ChIP_HELA_Human2.47213163
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.43184800
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.34451089
17* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.32860357
18TAF15_26573619_Chip-Seq_HEK293_Human2.28665213
19RBPJ_22232070_ChIP-Seq_NCS_Mouse2.25328271
20PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.24449132
21CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.21705547
22* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.06505401
23PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.04821865
24ER_23166858_ChIP-Seq_MCF-7_Human2.01264420
25FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.00532350
26HTT_18923047_ChIP-ChIP_STHdh_Human1.97239701
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.96937205
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.95949473
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.95578818
30NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.93197084
31NRF2_20460467_ChIP-Seq_MEFs_Mouse1.93197084
32FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.90805104
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88671226
34PPARA_22158963_ChIP-Seq_LIVER_Mouse1.88556385
35CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.87240640
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.86156517
37WT1_19549856_ChIP-ChIP_CCG9911_Human1.85684257
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.84210224
39AR_21572438_ChIP-Seq_LNCaP_Human1.81533282
40PADI4_21655091_ChIP-ChIP_MCF-7_Human1.81196136
41E2F4_17652178_ChIP-ChIP_JURKAT_Human1.80334235
42GBX2_23144817_ChIP-Seq_PC3_Human1.77597101
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.72208141
44VDR_23849224_ChIP-Seq_CD4+_Human1.69790211
45* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.69298859
46ETS1_20019798_ChIP-Seq_JURKAT_Human1.63865336
47HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.60797626
48CDX2_19796622_ChIP-Seq_MESCs_Mouse1.58805163
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.56651417
50VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.49212054
51TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.49101525
52MYC_18940864_ChIP-ChIP_HL60_Human1.48840338
53VDR_22108803_ChIP-Seq_LS180_Human1.48504677
54TRIM28_21343339_ChIP-Seq_HEK293_Human1.47777798
55EZH2_22144423_ChIP-Seq_EOC_Human1.46863874
56* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.43997180
57JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.42968847
58CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.41816258
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41198536
60STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.40925125
61KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.40450096
62RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.36704950
63FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.34281781
64POU5F1_16153702_ChIP-ChIP_HESCs_Human1.32701983
65EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.32465016
66MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31066029
67STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.30090583
68PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.30047273
69PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.28588245
70P300_19829295_ChIP-Seq_ESCs_Human1.26564529
71FUS_26573619_Chip-Seq_HEK293_Human1.25775680
72CMYC_18555785_Chip-Seq_ESCs_Mouse1.24464881
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.21690892
74RNF2_27304074_Chip-Seq_NSC_Mouse1.20970072
75FOXP3_21729870_ChIP-Seq_TREG_Human1.20344269
76PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.20009877
77SUZ12_18555785_Chip-Seq_ESCs_Mouse1.19882731
78KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19787326
79EOMES_21245162_ChIP-Seq_HESCs_Human1.19031310
80TAL1_26923725_Chip-Seq_HPCs_Mouse1.18645554
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18020239
82CBP_20019798_ChIP-Seq_JUKART_Human1.18020239
83TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17764017
84* CBX2_27304074_Chip-Seq_ESCs_Mouse1.16088238
85ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15880244
86* GABP_19822575_ChIP-Seq_HepG2_Human1.15209532
87YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14320424
88PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.14289603
89SMAD4_21799915_ChIP-Seq_A2780_Human1.12871753
90PIAS1_25552417_ChIP-Seq_VCAP_Human1.12398889
91SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.11567869
92* SRF_21415370_ChIP-Seq_HL-1_Mouse1.11327116
93P300_18555785_Chip-Seq_ESCs_Mouse1.11298525
94DCP1A_22483619_ChIP-Seq_HELA_Human1.11250119
95TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11104431
96PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10320267
97FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.08744091
98IRF8_21731497_ChIP-ChIP_J774_Mouse1.07089298
99NANOG_18555785_Chip-Seq_ESCs_Mouse1.06609920
100SOX2_16153702_ChIP-ChIP_HESCs_Human1.05846183
101SOX2_20726797_ChIP-Seq_SW620_Human1.05700616
102POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05514572
103* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.05269283
104SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04145098
105NOTCH1_21737748_ChIP-Seq_TLL_Human1.03758114
106NANOG_16153702_ChIP-ChIP_HESCs_Human1.03734694
107NANOG_19829295_ChIP-Seq_ESCs_Human1.03237867
108SOX2_19829295_ChIP-Seq_ESCs_Human1.03237867
109MYC_18555785_ChIP-Seq_MESCs_Mouse1.03061357
110RUNX1_27457419_Chip-Seq_LIVER_Mouse1.02710168
111SOX2_27498859_Chip-Seq_STOMACH_Mouse1.01457486
112STAT3_18555785_Chip-Seq_ESCs_Mouse1.00408698
113EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.00378618
114TP53_22573176_ChIP-Seq_HFKS_Human0.99829131
115RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.99510036
116EZH2_27294783_Chip-Seq_NPCs_Mouse0.99366538
117SMAD1_18555785_Chip-Seq_ESCs_Mouse0.99308087
118IRF1_19129219_ChIP-ChIP_H3396_Human0.99119241
119AR_25329375_ChIP-Seq_VCAP_Human0.99001218
120MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98380638
121FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.98271283
122EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97728181
123EED_16625203_ChIP-ChIP_MESCs_Mouse0.97377104
124EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97369249
125* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.96299242
126ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.96272095
127RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.95810191
128CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.94155146
129* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.93994777
130LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93860969
131KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.93643094
132AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92928817
133CRX_20693478_ChIP-Seq_RETINA_Mouse0.92921887
134SMAD4_21741376_ChIP-Seq_EPCs_Human0.92803267
135SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.92284947
136TCF4_22108803_ChIP-Seq_LS180_Human0.91972098
137REST_19997604_ChIP-ChIP_NEURONS_Mouse0.91892285
138ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.91818488
139PCGF2_27294783_Chip-Seq_ESCs_Mouse0.91027267
140SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90858168
141GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90825008
142EWS_26573619_Chip-Seq_HEK293_Human0.90371821
143UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90330380
144TP53_18474530_ChIP-ChIP_U2OS_Human0.90166322
145TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90030265
146P53_22387025_ChIP-Seq_ESCs_Mouse0.89523008
147CTBP2_25329375_ChIP-Seq_LNCAP_Human0.89382851
148FOXO3_23340844_ChIP-Seq_DLD1_Human0.89179554
149FOXA1_25552417_ChIP-Seq_VCAP_Human0.87746482
150SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.87173950
151SOX2_18555785_Chip-Seq_ESCs_Mouse0.86619222
152CTBP1_25329375_ChIP-Seq_LNCAP_Human0.86611136
153SOX17_20123909_ChIP-Seq_XEN_Mouse0.86041093
154KLF4_18555785_Chip-Seq_ESCs_Mouse0.85644170
155Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.85440036
156PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.85419698
157PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.85300205
158GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.85133689
159BMI1_23680149_ChIP-Seq_NPCS_Mouse0.84789235
160NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.84604697
161* CBP_21632823_ChIP-Seq_H3396_Human0.84518776

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination5.09651441
2MP0003806_abnormal_nucleotide_metabolis4.84996084
3MP0002139_abnormal_hepatobiliary_system4.47377136
4MP0003690_abnormal_glial_cell3.29698644
5MP0005360_urolithiasis3.21847057
6MP0003122_maternal_imprinting3.06115192
7MP0003950_abnormal_plasma_membrane3.02147779
8MP0005085_abnormal_gallbladder_physiolo2.74629834
9MP0009840_abnormal_foam_cell2.62621814
10MP0003195_calcinosis2.61665065
11MP0003329_amyloid_beta_deposits2.58048965
12MP0005083_abnormal_biliary_tract2.50936275
13MP0005451_abnormal_body_composition2.40679354
14MP0008875_abnormal_xenobiotic_pharmacok2.39521083
15MP0001346_abnormal_lacrimal_gland2.30346506
16MP0001529_abnormal_vocalization2.26470821
17MP0008058_abnormal_DNA_repair2.25209295
18MP0003121_genomic_imprinting2.20632323
19MP0003890_abnormal_embryonic-extraembry2.08444387
20MP0008789_abnormal_olfactory_epithelium2.02270891
21MP0001348_abnormal_lacrimal_gland2.00061045
22MP0004742_abnormal_vestibular_system1.98942144
23MP0005365_abnormal_bile_salt1.98046958
24MP0001905_abnormal_dopamine_level1.97571820
25MP0001984_abnormal_olfaction1.96941227
26MP0002938_white_spotting1.95570631
27MP0003136_yellow_coat_color1.92067165
28MP0004134_abnormal_chest_morphology1.89821386
29MP0005394_taste/olfaction_phenotype1.89075299
30MP0005499_abnormal_olfactory_system1.89075299
31MP0006072_abnormal_retinal_apoptosis1.88766931
32MP0003011_delayed_dark_adaptation1.88394024
33MP0010678_abnormal_skin_adnexa1.87435180
34MP0002822_catalepsy1.86161528
35MP0000604_amyloidosis1.85335540
36MP0006082_CNS_inflammation1.79536577
37MP0004142_abnormal_muscle_tone1.78757480
38MP0003634_abnormal_glial_cell1.78719162
39MP0003632_abnormal_nervous_system1.77449991
40MP0005253_abnormal_eye_physiology1.76818561
41MP0003656_abnormal_erythrocyte_physiolo1.75702294
42MP0003787_abnormal_imprinting1.73728576
43MP0005408_hypopigmentation1.68624610
44MP0000383_abnormal_hair_follicle1.68400092
45MP0002638_abnormal_pupillary_reflex1.67818640
46MP0002163_abnormal_gland_morphology1.67111807
47MP0005171_absent_coat_pigmentation1.65067117
48MP0008877_abnormal_DNA_methylation1.64644529
49MP0001485_abnormal_pinna_reflex1.64644145
50MP0005187_abnormal_penis_morphology1.63093700
51MP0006276_abnormal_autonomic_nervous1.56759986
52MP0000647_abnormal_sebaceous_gland1.56030496
53MP0003186_abnormal_redox_activity1.54870677
54MP0004270_analgesia1.51860417
55MP0005332_abnormal_amino_acid1.48387653
56MP0004885_abnormal_endolymph1.48016805
57MP0002102_abnormal_ear_morphology1.45140298
58MP0001293_anophthalmia1.44368234
59MP0000778_abnormal_nervous_system1.44031907
60MP0002653_abnormal_ependyma_morphology1.43856645
61MP0000631_abnormal_neuroendocrine_gland1.42821219
62MP0004381_abnormal_hair_follicle1.42562545
63MP0005248_abnormal_Harderian_gland1.40261968
64MP0010094_abnormal_chromosome_stability1.37250961
65MP0008995_early_reproductive_senescence1.36853407
66MP0002118_abnormal_lipid_homeostasis1.36145300
67MP0005645_abnormal_hypothalamus_physiol1.32973798
68MP0005410_abnormal_fertilization1.32322140
69MP0009046_muscle_twitch1.30307847
70MP0004133_heterotaxia1.29475034
71MP0001661_extended_life_span1.28693799
72MP0006292_abnormal_olfactory_placode1.28408682
73MP0000372_irregular_coat_pigmentation1.27478015
74MP0000462_abnormal_digestive_system1.24754391
75MP0002736_abnormal_nociception_after1.24692128
76MP0005423_abnormal_somatic_nervous1.24574418
77MP0006035_abnormal_mitochondrial_morpho1.23469753
78MP0002233_abnormal_nose_morphology1.23191028
79MP0008932_abnormal_embryonic_tissue1.21395981
80MP0003718_maternal_effect1.20485780
81MP0003880_abnormal_central_pattern1.20234184
82MP0005646_abnormal_pituitary_gland1.19474364
83MP0005379_endocrine/exocrine_gland_phen1.18296166
84MP0002557_abnormal_social/conspecific_i1.17788389
85MP0002229_neurodegeneration1.17178415
86MP0005584_abnormal_enzyme/coenzyme_acti1.15899775
87MP0002751_abnormal_autonomic_nervous1.15370577
88MP0002909_abnormal_adrenal_gland1.15132771
89MP0002234_abnormal_pharynx_morphology1.14695300
90MP0003567_abnormal_fetal_cardiomyocyte1.13919290
91MP0003786_premature_aging1.13488180
92MP0002572_abnormal_emotion/affect_behav1.12034243
93MP0005391_vision/eye_phenotype1.10810754
94MP0005084_abnormal_gallbladder_morpholo1.10329304
95MP0005409_darkened_coat_color1.09205861
96MP0003631_nervous_system_phenotype1.08031912
97MP0002295_abnormal_pulmonary_circulatio1.06612518
98MP0002272_abnormal_nervous_system1.06125294
99MP0003221_abnormal_cardiomyocyte_apopto1.05973506
100MP0003755_abnormal_palate_morphology1.04196491
101MP0009745_abnormal_behavioral_response1.03484592
102MP0001486_abnormal_startle_reflex1.02245034
103MP0001666_abnormal_nutrient_absorption1.02211324
104MP0000639_abnormal_adrenal_gland1.01683090
105MP0008438_abnormal_cutaneous_collagen1.01087482
106MP0000566_synostosis1.00317927
107MP0002138_abnormal_hepatobiliary_system0.99752008
108MP0003315_abnormal_perineum_morphology0.97333244
109MP0002933_joint_inflammation0.97276126
110MP0002837_dystrophic_cardiac_calcinosis0.96700013
111MP0003119_abnormal_digestive_system0.96014605
112MP0003937_abnormal_limbs/digits/tail_de0.94199490
113MP0005058_abnormal_lysosome_morphology0.93979735
114MP0001929_abnormal_gametogenesis0.92544811
115MP0010329_abnormal_lipoprotein_level0.92043210
116MP0003252_abnormal_bile_duct0.90837015
117MP0002063_abnormal_learning/memory/cond0.90353928
118MP0000685_abnormal_immune_system0.90190724
119MP0001764_abnormal_homeostasis0.88390770
120MP0001188_hyperpigmentation0.87579719
121MP0004043_abnormal_pH_regulation0.87373977
122MP0000427_abnormal_hair_cycle0.86866711
123MP0003635_abnormal_synaptic_transmissio0.86562099
124MP0002282_abnormal_trachea_morphology0.86336949
125MP0001968_abnormal_touch/_nociception0.86095762
126MP0004957_abnormal_blastocyst_morpholog0.86013881
127MP0002184_abnormal_innervation0.85371578
128MP0002796_impaired_skin_barrier0.85295851
129MP0000955_abnormal_spinal_cord0.85279086
130MP0003693_abnormal_embryo_hatching0.84768135
131MP0009765_abnormal_xenobiotic_induced0.84577681
132MP0000516_abnormal_urinary_system0.84254347
133MP0005367_renal/urinary_system_phenotyp0.84254347
134MP0004147_increased_porphyrin_level0.84014799
135MP0002734_abnormal_mechanical_nocicepti0.83963800
136MP0005386_behavior/neurological_phenoty0.83953233
137MP0004924_abnormal_behavior0.83953233
138MP0000579_abnormal_nail_morphology0.83935139
139MP0002067_abnormal_sensory_capabilities0.82805299
140MP0004215_abnormal_myocardial_fiber0.82636604
141MP0005551_abnormal_eye_electrophysiolog0.82470847
142MP0001286_abnormal_eye_development0.82388359
143MP0001177_atelectasis0.82258336
144MP0003698_abnormal_male_reproductive0.82028627
145MP0002210_abnormal_sex_determination0.82019438
146MP0008260_abnormal_autophagy0.81565037
147MP0006036_abnormal_mitochondrial_physio0.80328659
148MP0002148_abnormal_hypersensitivity_rea0.80027646
149MP0002090_abnormal_vision0.78936279
150MP0009697_abnormal_copulation0.78044058
151MP0005195_abnormal_posterior_eye0.77975210
152MP0004185_abnormal_adipocyte_glucose0.73622194
153MP0000762_abnormal_tongue_morphology0.73531919
154MP0001851_eye_inflammation0.73522946
155MP0001963_abnormal_hearing_physiology0.73490049
156MP0009250_abnormal_appendicular_skeleto0.72304971
157MP0001299_abnormal_eye_distance/0.69557144
158MP0003633_abnormal_nervous_system0.67227286
159MP0001790_abnormal_immune_system0.67105134
160MP0005387_immune_system_phenotype0.67105134
161MP0003075_altered_response_to0.65766323
162MP0001243_abnormal_dermal_layer0.65596803
163MP0000609_abnormal_liver_physiology0.62277653
164MP0002064_seizures0.62238665
165MP0001340_abnormal_eyelid_morphology0.61956929
166MP0003724_increased_susceptibility_to0.59933228
167MP0005164_abnormal_response_to0.59872260
168MP0003453_abnormal_keratinocyte_physiol0.59820458
169MP0003868_abnormal_feces_composition0.59800184
170MP0009785_altered_susceptibility_to0.59058666
171MP0009763_increased_sensitivity_to0.59050995
172MP0003938_abnormal_ear_development0.57188939
173MP0005395_other_phenotype0.56728193

Predicted human phenotypes

RankGene SetZ-score
1Parakeratosis (HP:0001036)6.45349703
2Degeneration of the lateral corticospinal tracts (HP:0002314)5.60357422
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.60357422
4Neurofibrillary tangles (HP:0002185)5.52809807
5Increased serum pyruvate (HP:0003542)5.35230814
6Abnormality of glycolysis (HP:0004366)5.35230814
7Intrahepatic cholestasis (HP:0001406)4.31895546
8Abnormality of the corticospinal tract (HP:0002492)4.27475861
9Cerebral inclusion bodies (HP:0100314)3.95057464
10Abnormality of aromatic amino acid family metabolism (HP:0004338)3.83032889
11Hypoplastic pelvis (HP:0008839)3.82864540
12Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.81668224
13Sensory axonal neuropathy (HP:0003390)3.78568667
14Congenital ichthyosiform erythroderma (HP:0007431)3.70402229
15Termporal pattern (HP:0011008)3.30874209
16Insidious onset (HP:0003587)3.30874209
17Hyperglycinemia (HP:0002154)3.29880016
18Peripheral hypomyelination (HP:0007182)3.17422515
19Xanthomatosis (HP:0000991)3.16305572
20Deep venous thrombosis (HP:0002625)2.98433794
21True hermaphroditism (HP:0010459)2.89544382
22Leukodystrophy (HP:0002415)2.86977626
23Onion bulb formation (HP:0003383)2.84642453
24Medial flaring of the eyebrow (HP:0010747)2.84600845
25Hypophosphatemic rickets (HP:0004912)2.80747344
26Cerebral hemorrhage (HP:0001342)2.77314632
27Hyperlipoproteinemia (HP:0010980)2.77243947
28Abnormality of the labia minora (HP:0012880)2.75385667
29Stridor (HP:0010307)2.75198751
30Hepatosplenomegaly (HP:0001433)2.71294604
31Cortical dysplasia (HP:0002539)2.70003412
32Abnormality of methionine metabolism (HP:0010901)2.68790959
33Autoamputation (HP:0001218)2.66199179
34Pancreatic fibrosis (HP:0100732)2.62304698
35Hypobetalipoproteinemia (HP:0003563)2.61017892
36Spastic paraparesis (HP:0002313)2.60137753
37Prolonged partial thromboplastin time (HP:0003645)2.57621569
38Irregular epiphyses (HP:0010582)2.55424273
39Spastic gait (HP:0002064)2.53608489
40Epiphyseal dysplasia (HP:0002656)2.52680929
41Gait imbalance (HP:0002141)2.52487987
42Epidermoid cyst (HP:0200040)2.51181012
43Congenital primary aphakia (HP:0007707)2.50303411
44Segmental peripheral demyelination/remyelination (HP:0003481)2.50015791
45Type II lissencephaly (HP:0007260)2.48207795
46Molar tooth sign on MRI (HP:0002419)2.46734525
47Abnormality of midbrain morphology (HP:0002418)2.46734525
48Pancreatic cysts (HP:0001737)2.45270059
49Lissencephaly (HP:0001339)2.42083937
50Poor suck (HP:0002033)2.41334194
51Renal Fanconi syndrome (HP:0001994)2.40778938
52Erythroderma (HP:0001019)2.37249577
53Supranuclear gaze palsy (HP:0000605)2.34711427
54Abnormality of the metopic suture (HP:0005556)2.33867599
55Abnormality of aspartate family amino acid metabolism (HP:0010899)2.33860071
56Nephrogenic diabetes insipidus (HP:0009806)2.33213290
57Scrotal hypoplasia (HP:0000046)2.33084389
58Abnormality of the phalanges of the 2nd finger (HP:0009541)2.32178859
59Steatorrhea (HP:0002570)2.30447461
60Slow saccadic eye movements (HP:0000514)2.30044001
61Small epiphyses (HP:0010585)2.28255670
62Short tibia (HP:0005736)2.28205569
63Adrenal hypoplasia (HP:0000835)2.27037039
64Progressive macrocephaly (HP:0004481)2.26802714
65Prolonged neonatal jaundice (HP:0006579)2.26791374
66Abnormal mitochondria in muscle tissue (HP:0008316)2.26563921
67Fat malabsorption (HP:0002630)2.26162830
68Anomalous pulmonary venous return (HP:0010772)2.25604333
69Sclerocornea (HP:0000647)2.25516701
70Methylmalonic acidemia (HP:0002912)2.25477638
71Myelomeningocele (HP:0002475)2.24306880
72Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.23409559
73Cerebellar dysplasia (HP:0007033)2.22975895
74Colon cancer (HP:0003003)2.21275933
75Partial agenesis of the corpus callosum (HP:0001338)2.20736467
76Abnormal auditory evoked potentials (HP:0006958)2.20604868
77Delayed epiphyseal ossification (HP:0002663)2.19843411
78Relative macrocephaly (HP:0004482)2.18982502
79Genital tract atresia (HP:0001827)2.18512620
80Bifid tongue (HP:0010297)2.16275244
81Polyphagia (HP:0002591)2.16054346
82Abnormal lung lobation (HP:0002101)2.14851013
83Intestinal atresia (HP:0011100)2.14080023
84Vaginal atresia (HP:0000148)2.13667597
85Intention tremor (HP:0002080)2.12428947
86Nephronophthisis (HP:0000090)2.11150591
87Axonal loss (HP:0003447)2.10277468
88Limb dystonia (HP:0002451)2.08397552
89Infantile muscular hypotonia (HP:0008947)2.08167122
90Broad alveolar ridges (HP:0000187)2.08114666
91Pachygyria (HP:0001302)2.07377264
92Aplasia/Hypoplasia of the tongue (HP:0010295)2.06925675
93Postaxial foot polydactyly (HP:0001830)2.06685367
94Epiphyseal stippling (HP:0010655)2.06480847
95Overlapping toe (HP:0001845)2.06370600
96Postaxial hand polydactyly (HP:0001162)2.05950894
97Hyperglycinuria (HP:0003108)2.05724319
98Aplasia/Hypoplasia of the tibia (HP:0005772)2.05454197
99Coronal craniosynostosis (HP:0004440)2.01031070
100Brushfield spots (HP:0001088)2.00997711
101Acute encephalopathy (HP:0006846)2.00884740
102Spastic tetraparesis (HP:0001285)2.00858275
103Drooling (HP:0002307)2.00082900
104Prominent metopic ridge (HP:0005487)1.99709220
105Amniotic constriction ring (HP:0009775)1.99513702
106Abnormality of placental membranes (HP:0011409)1.99513702
107Amyloidosis (HP:0011034)1.99259288
108Cupped ear (HP:0000378)1.98198638
109Cerebral hypomyelination (HP:0006808)1.98068659
110Acanthocytosis (HP:0001927)1.97150360
111Abnormality of serum amino acid levels (HP:0003112)1.96668651
112Paraparesis (HP:0002385)1.96458187
113Hypoglycemic coma (HP:0001325)1.94753742
114Abnormality of monocarboxylic acid metabolism (HP:0010996)1.93761134
115Postnatal microcephaly (HP:0005484)1.93416313
116Increased CSF lactate (HP:0002490)1.92624271
117Premature skin wrinkling (HP:0100678)1.91812628
118Abnormality of the pulmonary veins (HP:0011718)1.91732618
119Morphological abnormality of the pyramidal tract (HP:0002062)1.90604020
120Retinal dysplasia (HP:0007973)1.90148732
121Rickets (HP:0002748)1.88601050
122Mitochondrial inheritance (HP:0001427)1.88015550
123Specific learning disability (HP:0001328)1.87533935
124Akinesia (HP:0002304)1.87377750
125Abnormality of the vitreous humor (HP:0004327)1.87081834
126Medulloblastoma (HP:0002885)1.86648312
127Abnormal tarsal ossification (HP:0008369)1.85626197
128Pheochromocytoma (HP:0002666)1.84608419
129Clumsiness (HP:0002312)1.84432481
130Ileus (HP:0002595)1.84423622
131Cerebral edema (HP:0002181)1.83991460
132Volvulus (HP:0002580)1.83071870
133Acute necrotizing encephalopathy (HP:0006965)1.81988343
134Vertebral clefting (HP:0008428)1.81457227
135Methylmalonic aciduria (HP:0012120)1.81440360
136Hemiparesis (HP:0001269)1.80368328
137Absent septum pellucidum (HP:0001331)1.80257416
138Abnormality of the middle phalanges of the toes (HP:0010183)1.80255850
139Decreased testicular size (HP:0008734)1.80117481
140Male pseudohermaphroditism (HP:0000037)1.80020882
141Enlarged epiphyses (HP:0010580)1.79430880
142Neuroendocrine neoplasm (HP:0100634)1.78534849
143Facial hemangioma (HP:0000329)1.78514098
144Abolished electroretinogram (ERG) (HP:0000550)1.78168847
145Neoplasm of the adrenal gland (HP:0100631)1.75761617
146Aplasia of the musculature (HP:0100854)1.75717531
147Chronic hepatic failure (HP:0100626)1.75717404
148Hyperinsulinemic hypoglycemia (HP:0000825)1.75601925
149Abnormality of sulfur amino acid metabolism (HP:0004339)1.74588711
150Scanning speech (HP:0002168)1.74587332
151Metaphyseal dysplasia (HP:0100255)1.74555643
152Renal cortical cysts (HP:0000803)1.73760603
153Abnormal gallbladder morphology (HP:0012437)1.73428897
154Cholecystitis (HP:0001082)1.73387414
155Abnormal gallbladder physiology (HP:0012438)1.73387414
156Alacrima (HP:0000522)1.73323174
157Abnormality of the pons (HP:0007361)1.73169690
158Excessive salivation (HP:0003781)1.72771731
159Vascular calcification (HP:0004934)1.72736212
160Peripheral demyelination (HP:0011096)1.72558792
1613-Methylglutaconic aciduria (HP:0003535)1.72244723
162Supernumerary spleens (HP:0009799)1.71945792
163Polymicrogyria (HP:0002126)1.70976509
164Narrow forehead (HP:0000341)1.70661668
165Abnormality of serine family amino acid metabolism (HP:0010894)1.70184038
166Abnormality of glycine metabolism (HP:0010895)1.70184038
167Hypoplasia of the pons (HP:0012110)1.69300978
168Dandy-Walker malformation (HP:0001305)1.69092332
169Exercise-induced muscle cramps (HP:0003710)1.68843027
170Abnormality of alanine metabolism (HP:0010916)1.67916888
171Hyperalaninemia (HP:0003348)1.67916888
172Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.67916888
173Large for gestational age (HP:0001520)1.67509729
174Gastrointestinal atresia (HP:0002589)1.67076089
175Atonic seizures (HP:0010819)1.66677101
176Broad foot (HP:0001769)1.65683665
177Hepatoblastoma (HP:0002884)1.65609071
178Lipid accumulation in hepatocytes (HP:0006561)1.65564598
179Increased hepatocellular lipid droplets (HP:0006565)1.64271909
180Hepatic necrosis (HP:0002605)1.64227457
181Abnormality of the renal medulla (HP:0100957)1.62474309
182Hypsarrhythmia (HP:0002521)1.61095661

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.23905671
2EPHB14.91445546
3PBK4.62673538
4BCR4.08953476
5OXSR13.96065921
6TSSK63.12310364
7WNK33.10972130
8MAP4K23.08804333
9TRIM283.01139118
10MAPKAPK52.76985589
11MST42.60856262
12PKN12.60487348
13MET2.60085393
14WNK42.50299580
15SRPK12.46565392
16NEK12.40177986
17ERBB32.32845614
18LIMK12.27845941
19EIF2AK32.23092552
20WEE12.18270679
21TESK22.13628283
22MAP3K42.10161095
23EPHA41.79912814
24CSNK1G31.73321264
25MKNK21.71804448
26MAP2K71.71286375
27FGFR21.64804473
28CSNK1A1L1.63610583
29PLK41.61093718
30CDK191.57789168
31BMPR1B1.56181228
32PINK11.53519514
33WNK11.50769250
34PLK31.49537948
35FGR1.49026110
36ERBB41.46018903
37UHMK11.42166532
38DYRK21.41162717
39VRK11.32683346
40CSNK1G11.30255193
41TNIK1.29374070
42MAP3K141.25308897
43ZAK1.23571109
44TTK1.21464464
45BRSK21.21449277
46NEK61.18679985
47CLK11.16192219
48NTRK11.15802273
49MINK11.14644064
50CSNK1G21.14182939
51ARAF1.13383155
52ROCK21.12916643
53PRKCQ1.02702876
54FRK0.98769254
55DYRK30.97764828
56CAMK2B0.97596615
57NUAK10.95331650
58RPS6KA50.90425514
59IRAK20.89112078
60NTRK20.87421449
61PLK10.84764994
62SGK2230.84471137
63SGK4940.84471137
64CCNB10.83107041
65PAK30.81051954
66MAP3K120.81002423
67PRKCG0.80681171
68FER0.79687890
69CAMK2D0.79568763
70IRAK10.78196570
71MKNK10.77720781
72CASK0.75861887
73CDC70.72534935
74PRKD30.72146911
75RPS6KA40.70882129
76NTRK30.69820940
77EPHB20.68556796
78MAP3K130.68441237
79KSR10.67691433
80CAMK2G0.67683256
81IKBKB0.64677006
82PNCK0.63379859
83ICK0.61614952
84CDK140.61367557
85ABL20.61219849
86GRK10.60956315
87GSK3A0.60711117
88PRKCE0.57165070
89MAP2K40.56255134
90BLK0.55851421
91EPHA30.54519099
92BRSK10.54365784
93INSRR0.54348601
94MARK10.52332526
95PHKG20.51387294
96PHKG10.51387294
97CAMK2A0.50797653
98SIK30.49677725
99ACVR1B0.49547544
100MAP2K20.49293782
101ADRBK20.49161287
102CSNK1D0.48783720
103BCKDK0.48607467
104TRPM70.48302638
105STK160.47486949
106PRKD10.47063397
107STK100.46336348
108EIF2AK20.46082204
109IRAK40.45429787
110MAPK150.44304171
111FGFR40.44240328
112CDK150.43675053
113ATM0.41992285
114MAPK130.41440947
115AKT20.41247647
116DDR20.41008233
117MAP3K50.40530643
118CDK180.39422016
119CSF1R0.39382600
120MST1R0.39348877
121PAK60.39191945
122CSNK1E0.38910529
123CDK30.38671277
124CDK11A0.37413723
125TYRO30.36576791
126YES10.36159638
127PDPK10.36002814
128TBK10.35950827
129STK38L0.35176027
130MARK30.34872363
131DYRK1A0.34550695
132CSK0.34311158
133ATR0.34239871
134PRKG10.33865870
135FYN0.32876786
136TESK10.32162841
137BMX0.31975487
138CSNK1A10.31950768
139CSNK2A10.31385494
140CDK50.31205047
141FGFR10.31073779
142ERBB20.30590620
143CAMKK20.30454956
144PIM20.29876082
145PRKACB0.29407416
146PAK10.29325070
147STK40.29239667
148BMPR20.29067627
149BUB10.29048861
150LCK0.28321154
151MUSK0.28096899
152PLK20.26795731
153MAPKAPK20.26252361
154ABL10.26091747
155INSR0.25712665
156EIF2AK10.24722308
157KSR20.22651532
158PRKACA0.22227261
159IKBKE0.21526774

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001006.64519540
2* Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.59998763
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.62958655
4Fatty acid elongation_Homo sapiens_hsa000624.19132932
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.71555833
6Butanoate metabolism_Homo sapiens_hsa006502.46243741
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.08200115
8Ether lipid metabolism_Homo sapiens_hsa005652.07603744
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.04601348
10Histidine metabolism_Homo sapiens_hsa003402.04589618
11Sulfur metabolism_Homo sapiens_hsa009202.03245783
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.95405396
13Fatty acid metabolism_Homo sapiens_hsa012121.74439826
14Nitrogen metabolism_Homo sapiens_hsa009101.69719305
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.67432752
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.67294856
17Peroxisome_Homo sapiens_hsa041461.58211986
18Steroid hormone biosynthesis_Homo sapiens_hsa001401.52806322
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.47893035
20Propanoate metabolism_Homo sapiens_hsa006401.43524847
21Basal transcription factors_Homo sapiens_hsa030221.36346733
22RNA polymerase_Homo sapiens_hsa030201.35361905
23Tryptophan metabolism_Homo sapiens_hsa003801.34788246
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.33468931
25Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.32170209
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.31272591
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.28996024
28Non-homologous end-joining_Homo sapiens_hsa034501.27720663
29Mismatch repair_Homo sapiens_hsa034301.27354947
30Linoleic acid metabolism_Homo sapiens_hsa005911.26859863
31Chemical carcinogenesis_Homo sapiens_hsa052041.25751545
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.24782584
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.22252120
34Retinol metabolism_Homo sapiens_hsa008301.18796984
35Vitamin B6 metabolism_Homo sapiens_hsa007501.18668467
36Arginine and proline metabolism_Homo sapiens_hsa003301.18283909
37Fatty acid degradation_Homo sapiens_hsa000711.18216231
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.15392362
39Protein export_Homo sapiens_hsa030601.15183989
40Fanconi anemia pathway_Homo sapiens_hsa034601.12101768
41RNA degradation_Homo sapiens_hsa030181.06822780
42Glutathione metabolism_Homo sapiens_hsa004801.05369777
43Nucleotide excision repair_Homo sapiens_hsa034201.05343100
44Spliceosome_Homo sapiens_hsa030401.03736132
45Allograft rejection_Homo sapiens_hsa053301.02701661
46Oxidative phosphorylation_Homo sapiens_hsa001901.01273245
47Homologous recombination_Homo sapiens_hsa034401.00197530
48Complement and coagulation cascades_Homo sapiens_hsa046100.99863947
49Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.99171756
50Tyrosine metabolism_Homo sapiens_hsa003500.97146245
51Autoimmune thyroid disease_Homo sapiens_hsa053200.94022036
52Pyruvate metabolism_Homo sapiens_hsa006200.93185536
53Sphingolipid metabolism_Homo sapiens_hsa006000.93057209
54Fatty acid biosynthesis_Homo sapiens_hsa000610.90664402
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.89820554
56Graft-versus-host disease_Homo sapiens_hsa053320.89396798
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88503667
58Folate biosynthesis_Homo sapiens_hsa007900.86536748
59Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.85595951
60RNA transport_Homo sapiens_hsa030130.85527313
61Maturity onset diabetes of the young_Homo sapiens_hsa049500.85246356
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85093467
63Phototransduction_Homo sapiens_hsa047440.83846833
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83793331
65beta-Alanine metabolism_Homo sapiens_hsa004100.82680512
66Arginine biosynthesis_Homo sapiens_hsa002200.81934295
67Phenylalanine metabolism_Homo sapiens_hsa003600.80369770
68Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80310652
69Nicotine addiction_Homo sapiens_hsa050330.77243199
70PPAR signaling pathway_Homo sapiens_hsa033200.75950342
71Proteasome_Homo sapiens_hsa030500.75853629
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72065514
73Parkinsons disease_Homo sapiens_hsa050120.68269691
74DNA replication_Homo sapiens_hsa030300.66334096
75Vitamin digestion and absorption_Homo sapiens_hsa049770.65899190
76GABAergic synapse_Homo sapiens_hsa047270.65698980
77Staphylococcus aureus infection_Homo sapiens_hsa051500.64151407
78Collecting duct acid secretion_Homo sapiens_hsa049660.63061779
79One carbon pool by folate_Homo sapiens_hsa006700.62032108
80Oocyte meiosis_Homo sapiens_hsa041140.56928421
81* Metabolic pathways_Homo sapiens_hsa011000.55149660
82Purine metabolism_Homo sapiens_hsa002300.54109218
83Fat digestion and absorption_Homo sapiens_hsa049750.53978827
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.52674824
85Axon guidance_Homo sapiens_hsa043600.52381003
86Alzheimers disease_Homo sapiens_hsa050100.51860955
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51826817
88Circadian rhythm_Homo sapiens_hsa047100.51735702
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51186287
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49348741
91Base excision repair_Homo sapiens_hsa034100.49236159
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49069486
93Rheumatoid arthritis_Homo sapiens_hsa053230.48631665
94mRNA surveillance pathway_Homo sapiens_hsa030150.48529717
95Bile secretion_Homo sapiens_hsa049760.47548907
96Dopaminergic synapse_Homo sapiens_hsa047280.46881771
97Arachidonic acid metabolism_Homo sapiens_hsa005900.46495344
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44957160
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44763398
100Pyrimidine metabolism_Homo sapiens_hsa002400.43940034
101Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.42910978
102Cocaine addiction_Homo sapiens_hsa050300.41928000
103ABC transporters_Homo sapiens_hsa020100.41610861
104Cell cycle_Homo sapiens_hsa041100.40566704
105Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.40303948
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40080569
107Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.40023290
108Malaria_Homo sapiens_hsa051440.38203532
109Ovarian steroidogenesis_Homo sapiens_hsa049130.37895844
110Cardiac muscle contraction_Homo sapiens_hsa042600.35333877
111Prion diseases_Homo sapiens_hsa050200.33796559
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32423753
113Caffeine metabolism_Homo sapiens_hsa002320.31557610
114Alcoholism_Homo sapiens_hsa050340.29932767
115Drug metabolism - other enzymes_Homo sapiens_hsa009830.28233658
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.27306875
117Regulation of autophagy_Homo sapiens_hsa041400.27059147
118Amphetamine addiction_Homo sapiens_hsa050310.26532170
119Selenocompound metabolism_Homo sapiens_hsa004500.26473698
120Phagosome_Homo sapiens_hsa041450.26124374
121Vibrio cholerae infection_Homo sapiens_hsa051100.25878608
122Renal cell carcinoma_Homo sapiens_hsa052110.25454018
123African trypanosomiasis_Homo sapiens_hsa051430.24643956
124Tight junction_Homo sapiens_hsa045300.21805428
125Biosynthesis of amino acids_Homo sapiens_hsa012300.20507047
126Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.19758017
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.19086662
128Carbon metabolism_Homo sapiens_hsa012000.18978611
129Asthma_Homo sapiens_hsa053100.18894114
130Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.18027195
131Cyanoamino acid metabolism_Homo sapiens_hsa004600.17022496
132Glycerolipid metabolism_Homo sapiens_hsa005610.16688516
133Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.16377792
134Serotonergic synapse_Homo sapiens_hsa047260.15645833
135Intestinal immune network for IgA production_Homo sapiens_hsa046720.15394027
136Type I diabetes mellitus_Homo sapiens_hsa049400.14245899
137Mineral absorption_Homo sapiens_hsa049780.13868902
138Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.13766251
139Huntingtons disease_Homo sapiens_hsa050160.09800250
140Pentose phosphate pathway_Homo sapiens_hsa000300.09550849
141ECM-receptor interaction_Homo sapiens_hsa045120.07142132
142Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.07065929
143NOD-like receptor signaling pathway_Homo sapiens_hsa046210.06530948
144Starch and sucrose metabolism_Homo sapiens_hsa005000.06524277

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