IDI2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene catalyzes the conversion of isopentenyl diphosphate to dimethylallyl diphosphate, which is a precursor for the synthesis of cholesterol and other isoprenoids. This gene, which is a product of an ancestral gene duplication event, encodes a protein that may be involved in the aggregation of alpha-synuclein in the cerebral cortex of patients with Lewy body disease. In addition, segmental copy number gains in this locus have been associated with sporadic amyotrophic lateral sclerosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-mediated cell contraction (GO:0070252)9.97549102
2skeletal muscle contraction (GO:0003009)9.64929212
3response to muscle activity (GO:0014850)8.89305955
4regulation of relaxation of muscle (GO:1901077)7.99246713
5myofibril assembly (GO:0030239)7.93058904
6actin filament-based movement (GO:0030048)7.24985964
7striated muscle contraction (GO:0006941)6.95029032
8sarcomere organization (GO:0045214)6.92300670
9skeletal muscle fiber development (GO:0048741)6.82059480
10creatine metabolic process (GO:0006600)6.63953392
11plasma membrane repair (GO:0001778)6.45053650
12response to stimulus involved in regulation of muscle adaptation (GO:0014874)6.32341680
13positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.30633072
14myotube cell development (GO:0014904)6.16039258
15regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.85705890
16cardiac myofibril assembly (GO:0055003)5.59924998
17muscle contraction (GO:0006936)5.56406979
18skeletal muscle adaptation (GO:0043501)5.49666946
19muscle cell cellular homeostasis (GO:0046716)5.47603062
20response to inactivity (GO:0014854)5.46174544
21glycogen catabolic process (GO:0005980)5.20291162
22muscle fiber development (GO:0048747)5.19294784
23muscle system process (GO:0003012)5.01347053
24actomyosin structure organization (GO:0031032)4.97734972
25NIK/NF-kappaB signaling (GO:0038061)4.94126391
26glucan catabolic process (GO:0009251)4.87715108
27regulation of cell communication by electrical coupling (GO:0010649)4.79246882
28cardiac muscle contraction (GO:0060048)4.76080546
29negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.68677725
30skeletal muscle tissue development (GO:0007519)4.67436971
31glycogen biosynthetic process (GO:0005978)4.64215503
32glucan biosynthetic process (GO:0009250)4.64215503
33regulation of actin filament-based movement (GO:1903115)4.63796155
34cellular polysaccharide catabolic process (GO:0044247)4.51847036
35regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.47424705
36AMP metabolic process (GO:0046033)4.30115355
37regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.23404017
38cardiac muscle hypertrophy (GO:0003300)4.23382570
39regulation of RIG-I signaling pathway (GO:0039535)4.22600953
40response to activity (GO:0014823)4.22560784
41negative thymic T cell selection (GO:0045060)4.21466055
42striated muscle adaptation (GO:0014888)4.20758000
43skeletal muscle tissue regeneration (GO:0043403)4.15714579
44negative T cell selection (GO:0043383)4.13137760
45regulation of immunoglobulin secretion (GO:0051023)4.11342715
46fructose metabolic process (GO:0006000)4.09071682
47negative regulation of potassium ion transmembrane transport (GO:1901380)4.06806385
48polysaccharide catabolic process (GO:0000272)4.06801176
49striated muscle hypertrophy (GO:0014897)4.03929773
50ubiquinone biosynthetic process (GO:0006744)4.02320661
51glycogen metabolic process (GO:0005977)3.99176720
52adult heart development (GO:0007512)3.98215149
53muscle cell fate commitment (GO:0042693)3.96944707
54muscle structure development (GO:0061061)3.94290459
55DNA synthesis involved in DNA repair (GO:0000731)3.93786017
56muscle organ development (GO:0007517)3.93541468
57glucan metabolic process (GO:0044042)3.90879543
58cellular glucan metabolic process (GO:0006073)3.90879543
59striated muscle cell development (GO:0055002)3.90440923
60neuromuscular synaptic transmission (GO:0007274)3.89158458
61regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.84715376
62regulation of striated muscle contraction (GO:0006942)3.81887727
63striated muscle atrophy (GO:0014891)3.81064126
64myoblast fusion (GO:0007520)3.73909357
65muscle organ morphogenesis (GO:0048644)3.71109135
66microtubule depolymerization (GO:0007019)3.66960522
67regulation of myoblast differentiation (GO:0045661)3.66001836
68negative regulation of calcium ion transmembrane transport (GO:1903170)3.63930863
69negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.63930863
70otic vesicle formation (GO:0030916)3.63398083
71ubiquinone metabolic process (GO:0006743)3.61011598
72muscle tissue morphogenesis (GO:0060415)3.59256076
73regulation of sarcomere organization (GO:0060297)3.58267216
74IMP metabolic process (GO:0046040)3.55674027
75muscle hypertrophy (GO:0014896)3.51018877
76telomere maintenance via semi-conservative replication (GO:0032201)3.50320598
77NADH metabolic process (GO:0006734)3.49581843
78neuronal action potential propagation (GO:0019227)3.48876854
792-oxoglutarate metabolic process (GO:0006103)3.47291930
80muscle atrophy (GO:0014889)3.46514384
81DNA double-strand break processing (GO:0000729)3.44491849
82gluconeogenesis (GO:0006094)3.44231383
83negative regulation of muscle contraction (GO:0045932)3.42092743
84cardiac muscle tissue morphogenesis (GO:0055008)3.41992353
85quinone biosynthetic process (GO:1901663)3.39879450
86muscle cell development (GO:0055001)3.37752276
87regulation of calcium ion transmembrane transporter activity (GO:1901019)3.37560721
88regulation of calcium ion transmembrane transport (GO:1903169)3.37560721
89cardiac muscle cell development (GO:0055013)3.37156258
90muscle adaptation (GO:0043500)3.36627859
91regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.35938278
92positive regulation of myotube differentiation (GO:0010831)3.33494556
93replicative senescence (GO:0090399)3.33417811
94CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.32096594
95relaxation of muscle (GO:0090075)3.30202415
96regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.29697722
97striated muscle tissue development (GO:0014706)3.29019145
98DNA-dependent DNA replication (GO:0006261)3.27291886
99positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.26172192
100negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.25020217
101T cell lineage commitment (GO:0002360)3.24693054
102carnitine shuttle (GO:0006853)3.23903837
103telomere maintenance via telomere lengthening (GO:0010833)3.23209328
104regulation of membrane repolarization (GO:0060306)3.22745863
105regulation of nuclear cell cycle DNA replication (GO:0033262)3.22335268
106CENP-A containing nucleosome assembly (GO:0034080)3.19806268
107positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.17894618
108syncytium formation by plasma membrane fusion (GO:0000768)3.16708406
109myotube differentiation (GO:0014902)3.15494121
110DNA strand elongation (GO:0022616)3.14668325
111response to mercury ion (GO:0046689)3.14443734
112DNA strand elongation involved in DNA replication (GO:0006271)3.14400221
113telomere maintenance via recombination (GO:0000722)3.13533232
114cellular carbohydrate catabolic process (GO:0044275)3.12564177
115meiotic chromosome segregation (GO:0045132)3.12031371
116hexose biosynthetic process (GO:0019319)3.09657968
117DNA replication initiation (GO:0006270)3.09515463
118cardiac cell development (GO:0055006)3.08241872
119negative regulation of protein localization to cell surface (GO:2000009)3.08135701
120mitotic metaphase plate congression (GO:0007080)3.06467668
121dendritic cell chemotaxis (GO:0002407)3.05279931
122kinetochore organization (GO:0051383)3.02048805
123nucleotide-excision repair, DNA gap filling (GO:0006297)3.01830339
124DNA replication checkpoint (GO:0000076)3.00952217
125regulation of mitotic spindle checkpoint (GO:1903504)2.99152431
126regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.99152431
127chromatin remodeling at centromere (GO:0031055)2.99104252
128deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.98926008
129negative regulation of DNA-dependent DNA replication (GO:2000104)2.97193413
130regulation of double-strand break repair via homologous recombination (GO:0010569)2.96226783
131energy homeostasis (GO:0097009)2.95741584
132positive T cell selection (GO:0043368)2.95623714
133positive regulation of interleukin-17 production (GO:0032740)2.95278474
134kinetochore assembly (GO:0051382)2.95037338
135mitotic recombination (GO:0006312)2.92017398
136T cell selection (GO:0045058)2.87024576
137tRNA methylation (GO:0030488)2.86749819
138telomere maintenance via telomerase (GO:0007004)2.84612897
139positive regulation of cell cycle checkpoint (GO:1901978)2.84500550
140antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.84210617
141IMP biosynthetic process (GO:0006188)2.84163482
142tyrosine phosphorylation of STAT protein (GO:0007260)2.83179578
1437-methylguanosine mRNA capping (GO:0006370)2.82595003
144termination of RNA polymerase III transcription (GO:0006386)2.81123712
145transcription elongation from RNA polymerase III promoter (GO:0006385)2.81123712
146RNA-dependent DNA replication (GO:0006278)2.80244362
147superoxide anion generation (GO:0042554)2.79855979
148RNA capping (GO:0036260)2.79708250
1497-methylguanosine RNA capping (GO:0009452)2.79708250
150T-helper 1 type immune response (GO:0042088)2.78849383
151mismatch repair (GO:0006298)2.76550798
152DNA catabolic process, exonucleolytic (GO:0000738)2.74991274
153purine nucleobase biosynthetic process (GO:0009113)2.73420102
154transcription elongation from RNA polymerase I promoter (GO:0006362)2.71026648
155histone H2A acetylation (GO:0043968)2.68379565
156pyrimidine dimer repair (GO:0006290)2.67489826
157positive thymic T cell selection (GO:0045059)2.66475297
158DNA replication-independent nucleosome organization (GO:0034724)2.65028290
159DNA replication-independent nucleosome assembly (GO:0006336)2.65028290
160telomere organization (GO:0032200)2.64786768
161regulation of interleukin-12 biosynthetic process (GO:0045075)2.63810557
162pseudouridine synthesis (GO:0001522)2.62495436
163intra-S DNA damage checkpoint (GO:0031573)2.61529795
164telomere maintenance (GO:0000723)2.60893977
165ribosome biogenesis (GO:0042254)2.60580308
166negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.60478857
167negative regulation of DNA-templated transcription, elongation (GO:0032785)2.60478857
168thymic T cell selection (GO:0045061)2.60402066
169tolerance induction (GO:0002507)2.60227924
170translesion synthesis (GO:0019985)2.59596616
171rRNA modification (GO:0000154)2.59380459
172spliceosomal snRNP assembly (GO:0000387)2.58429551
173positive regulation of alpha-beta T cell proliferation (GO:0046641)2.57779838
174maturation of 5.8S rRNA (GO:0000460)2.56062233
175attachment of spindle microtubules to kinetochore (GO:0008608)2.56050758
176ribosome assembly (GO:0042255)2.54761018
177regulation of spindle organization (GO:0090224)2.54722839
178transcription-coupled nucleotide-excision repair (GO:0006283)2.54142878
179regulation of DNA endoreduplication (GO:0032875)2.53443043
180negative regulation of telomere maintenance (GO:0032205)2.50981103
181neutrophil activation involved in immune response (GO:0002283)2.50230365
182DNA biosynthetic process (GO:0071897)2.47816436
183positive regulation of natural killer cell differentiation (GO:0032825)2.47743109
184transcription from RNA polymerase I promoter (GO:0006360)2.47257903
185DNA ligation (GO:0006266)2.47012834
186lymphoid progenitor cell differentiation (GO:0002320)2.46545441
187termination of RNA polymerase I transcription (GO:0006363)2.45918931
188regulation of hypersensitivity (GO:0002883)2.45818025
189regulation of mitotic spindle organization (GO:0060236)2.45680452
190maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.45291842
191protein localization to kinetochore (GO:0034501)2.45182983
192spindle checkpoint (GO:0031577)2.44321131
193rRNA methylation (GO:0031167)2.43906913
194positive regulation of protein import into nucleus, translocation (GO:0033160)2.43210466
195positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.43038307
196positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.41442997
197actin-myosin filament sliding (GO:0033275)12.1555104
198muscle filament sliding (GO:0030049)12.1555104
199sarcoplasmic reticulum calcium ion transport (GO:0070296)10.3362719
200regulation of skeletal muscle contraction (GO:0014819)10.1646750

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.62724128
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.30889521
3RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.53056665
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.37807849
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.27674582
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.14805865
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.14351326
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.03974445
9ESR1_20079471_ChIP-ChIP_T-47D_Human2.76121471
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.69378944
11VDR_22108803_ChIP-Seq_LS180_Human2.62240347
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.56136739
13NOTCH1_21737748_ChIP-Seq_TLL_Human2.51543350
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.50823583
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.41846578
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.41290222
17CDX2_19796622_ChIP-Seq_MESCs_Mouse2.40991648
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.37991390
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.35534144
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.34353394
21GBX2_23144817_ChIP-Seq_PC3_Human2.27945361
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.27675617
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.27430037
24BP1_19119308_ChIP-ChIP_Hs578T_Human2.26208637
25ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.24155200
26MYC_18555785_ChIP-Seq_MESCs_Mouse2.19404725
27SMAD_19615063_ChIP-ChIP_OVARY_Human2.16993709
28CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.12673214
29FOXM1_23109430_ChIP-Seq_U2OS_Human2.08811388
30PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse2.07957568
31FLI1_27457419_Chip-Seq_LIVER_Mouse2.02690994
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.01444093
33E2F7_22180533_ChIP-Seq_HELA_Human10.1589152
34EP300_21415370_ChIP-Seq_HL-1_Mouse1.96908231
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.96890118
36STAT4_19710469_ChIP-ChIP_TH1__Mouse1.94147001
37FOXP3_21729870_ChIP-Seq_TREG_Human1.93351852
38EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.89985279
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.89666246
40TP63_19390658_ChIP-ChIP_HaCaT_Human1.89550554
41GABP_17652178_ChIP-ChIP_JURKAT_Human1.86948635
42STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.86816716
43BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.86393332
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.85826956
45VDR_23849224_ChIP-Seq_CD4+_Human1.83471077
46TBX20_22328084_ChIP-Seq_HEART_Mouse1.83128359
47TBX20_22080862_ChIP-Seq_HEART_Mouse1.83128359
48SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.81996953
49MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.80625311
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.75593313
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.69521456
52GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.68212307
53E2F1_21310950_ChIP-Seq_MCF-7_Human1.65698767
54ETS1_20019798_ChIP-Seq_JURKAT_Human1.65050282
55PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.63771623
56SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.62718302
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.62534631
58TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62034381
59ELK1_19687146_ChIP-ChIP_HELA_Human1.60077118
60HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.54050706
61EGR1_19374776_ChIP-ChIP_THP-1_Human1.51367629
62NFE2_27457419_Chip-Seq_LIVER_Mouse1.49041417
63MYC_19079543_ChIP-ChIP_MESCs_Mouse1.48142299
64EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.48053440
65EZH2_27294783_Chip-Seq_ESCs_Mouse1.47029401
66SUZ12_27294783_Chip-Seq_NPCs_Mouse1.46378071
67HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.44819976
68MYC_18940864_ChIP-ChIP_HL60_Human1.44302384
69PCGF2_27294783_Chip-Seq_NPCs_Mouse1.44045089
70MYC_18358816_ChIP-ChIP_MESCs_Mouse1.42884698
71MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.42464981
72IRF1_19129219_ChIP-ChIP_H3396_Human1.41959252
73MYC_19030024_ChIP-ChIP_MESCs_Mouse1.41217826
74ER_23166858_ChIP-Seq_MCF-7_Human1.40328802
75RBPJ_22232070_ChIP-Seq_NCS_Mouse1.40219236
76POU5F1_16153702_ChIP-ChIP_HESCs_Human1.38777658
77KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.35749827
78STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.35211966
79CTCF_27219007_Chip-Seq_Bcells_Human1.35099596
80AR_21572438_ChIP-Seq_LNCaP_Human1.32505779
81EZH2_27304074_Chip-Seq_ESCs_Mouse1.30477700
82TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29887041
83IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27447214
84CBP_20019798_ChIP-Seq_JUKART_Human1.27447214
85YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21080097
86P53_22127205_ChIP-Seq_FIBROBLAST_Human1.18141282
87ZNF274_21170338_ChIP-Seq_K562_Hela1.17995800
88KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17774845
89HTT_18923047_ChIP-ChIP_STHdh_Human1.17540681
90CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.16192970
91GATA4_21415370_ChIP-Seq_HL-1_Mouse1.15121923
92NANOG_19829295_ChIP-Seq_ESCs_Human1.14206943
93SOX2_19829295_ChIP-Seq_ESCs_Human1.14206943
94SPI1_23547873_ChIP-Seq_NB4_Human1.13936757
95FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12932271
96CIITA_25753668_ChIP-Seq_RAJI_Human1.10645196
97SALL1_21062744_ChIP-ChIP_HESCs_Human1.10499651
98HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09941434
99CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.09658147
100VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.09599298
101JARID2_20075857_ChIP-Seq_MESCs_Mouse1.09271237
102FUS_26573619_Chip-Seq_HEK293_Human1.09151642
103ZFP57_27257070_Chip-Seq_ESCs_Mouse1.08666076
104* OCT4_20526341_ChIP-Seq_ESCs_Human1.08162156
105GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.08159425
106ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06672809
107CRX_20693478_ChIP-Seq_RETINA_Mouse1.06603745
108MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.05926246
109IGF1R_20145208_ChIP-Seq_DFB_Human1.05616339
110PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.04945126
111BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04535829
112EWS_26573619_Chip-Seq_HEK293_Human1.04249342
113* KAP1_22055183_ChIP-Seq_ESCs_Mouse1.04049069
114TDRD3_21172665_ChIP-Seq_MCF-7_Human1.03576099
115NMYC_18555785_Chip-Seq_ESCs_Mouse1.03223401
116LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.01265418
117E2F1_18555785_ChIP-Seq_MESCs_Mouse1.01099725
118MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.00695986
119STAT3_18555785_Chip-Seq_ESCs_Mouse1.00534513
120SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.00144127
121MTF2_20144788_ChIP-Seq_MESCs_Mouse0.99971890
122SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99777911
123THAP11_20581084_ChIP-Seq_MESCs_Mouse0.99478199
124AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99180273
125NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.99178061
126RUNX1_27457419_Chip-Seq_LIVER_Mouse0.98505486
127LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98443848
128EZH2_27294783_Chip-Seq_NPCs_Mouse0.97845096
129NELFA_20434984_ChIP-Seq_ESCs_Mouse0.97501547
130CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.97153940
131STAT1_20625510_ChIP-Seq_HELA_Human0.97021217
132GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96191353
133DCP1A_22483619_ChIP-Seq_HELA_Human0.96113541
134TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95768161
135MYCN_18555785_ChIP-Seq_MESCs_Mouse0.95520804
136SCL_19346495_ChIP-Seq_HPC-7_Human0.95490361
137DROSHA_22980978_ChIP-Seq_HELA_Human0.95458819
138IRF8_27001747_Chip-Seq_BMDM_Mouse0.95310399
139PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94922488
140SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.93946587
141POU3F2_20337985_ChIP-ChIP_501MEL_Human0.93557489
142SOX2_21211035_ChIP-Seq_LN229_Gbm0.92739473
143OCT4_18555785_Chip-Seq_ESCs_Mouse0.92531157
144SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.92506552
145YY1_21170310_ChIP-Seq_MESCs_Mouse0.92203070
146XRN2_22483619_ChIP-Seq_HELA_Human0.90970894
147RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.90810756
148* NANOG_20526341_ChIP-Seq_ESCs_Human0.90794571
149EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.90327790
150MYB_26560356_Chip-Seq_TH1_Human0.90219793
151PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.90046755
152CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.90007511
153JARID2_20064375_ChIP-Seq_MESCs_Mouse0.89967186
154SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.89673072
155TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89663684
156POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89663684
157SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.88999399
158SUZ12_18555785_Chip-Seq_ESCs_Mouse0.88471021
159PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88146226
160TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.87698514
161CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.87539551
162SUZ12_27294783_Chip-Seq_ESCs_Mouse0.87461474
163GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87015826
164GATA6_21074721_ChIP-Seq_CACO-2_Human0.86662298
165PHF8_20622853_ChIP-Seq_HELA_Human0.86499059
166SPI1_20517297_ChIP-Seq_HL60_Human0.86459349
167EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.86265923
168GABP_19822575_ChIP-Seq_HepG2_Human0.86139971
169NFYB_21822215_ChIP-Seq_K562_Human0.85855299
170UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.85709085
171MYB_26560356_Chip-Seq_TH2_Human0.85617078
172SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.85294772
173CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.85205749
174NANOG_18555785_ChIP-Seq_MESCs_Mouse0.85083017
175OCT4_21477851_ChIP-Seq_ESCs_Mouse0.84394591
176KLF4_18555785_Chip-Seq_ESCs_Mouse0.83971224
177TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.83593915
178NCOR_22424771_ChIP-Seq_293T_Human0.82510217
179EZH2_18974828_ChIP-Seq_MESCs_Mouse0.82481249
180RNF2_18974828_ChIP-Seq_MESCs_Mouse0.82481249
181SA1_27219007_Chip-Seq_Bcells_Human0.81992505
182SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.81728129
183* CBP_21632823_ChIP-Seq_H3396_Human0.81703147
184MYC_27129775_Chip-Seq_CORNEA_Mouse0.81205971
185RNF2_27304074_Chip-Seq_ESCs_Mouse0.80971642
186TP53_20018659_ChIP-ChIP_R1E_Mouse0.80953262
187NFIB_24661679_ChIP-Seq_LUNG_Mouse0.79388285
188TAF2_19829295_ChIP-Seq_ESCs_Human0.78690437

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue6.91201853
2MP0004145_abnormal_muscle_electrophysio6.71952720
3MP0000749_muscle_degeneration6.42238934
4MP0000751_myopathy5.26073168
5MP0004036_abnormal_muscle_relaxation4.17948862
6MP0001348_abnormal_lacrimal_gland3.67305642
7MP0002106_abnormal_muscle_physiology3.49127462
8MP0000759_abnormal_skeletal_muscle3.27692689
9MP0000747_muscle_weakness3.24250001
10MP0004084_abnormal_cardiac_muscle3.22903730
11MP0001188_hyperpigmentation3.19916880
12MP0004087_abnormal_muscle_fiber3.19464630
13MP0002837_dystrophic_cardiac_calcinosis3.14471854
14MP0002163_abnormal_gland_morphology3.13824042
15MP0002269_muscular_atrophy3.10031652
16MP0010094_abnormal_chromosome_stability3.09330900
17MP0005369_muscle_phenotype3.04820170
18MP0005671_abnormal_response_to3.03931532
19MP0003693_abnormal_embryo_hatching3.03587747
20MP0001835_abnormal_antigen_presentation2.97766519
21MP0001346_abnormal_lacrimal_gland2.92880885
22MP0005330_cardiomyopathy2.87370753
23MP0002332_abnormal_exercise_endurance2.84668964
24MP0005620_abnormal_muscle_contractility2.84085564
25MP0008057_abnormal_DNA_replication2.83132086
26MP0003763_abnormal_thymus_physiology2.74013818
27MP0004233_abnormal_muscle_weight2.71627358
28MP0003111_abnormal_nucleus_morphology2.68902355
29MP0000750_abnormal_muscle_regeneration2.66424300
30MP0008058_abnormal_DNA_repair2.61523972
31MP0002396_abnormal_hematopoietic_system2.51501121
32MP0004130_abnormal_muscle_cell2.51396513
33MP0000685_abnormal_immune_system2.39069917
34MP0005075_abnormal_melanosome_morpholog2.38244024
35MP0006036_abnormal_mitochondrial_physio2.29503076
36MP0003718_maternal_effect2.20119107
37MP0002102_abnormal_ear_morphology2.18071110
38MP0004215_abnormal_myocardial_fiber2.12593859
39MP0008007_abnormal_cellular_replicative2.12318784
40MP0002972_abnormal_cardiac_muscle2.09532949
41MP0003077_abnormal_cell_cycle2.08681549
42MP0009333_abnormal_splenocyte_physiolog2.07995297
43MP0002138_abnormal_hepatobiliary_system2.05349945
44MP0002108_abnormal_muscle_morphology2.01990984
45MP0002148_abnormal_hypersensitivity_rea2.00684348
46MP0002876_abnormal_thyroid_physiology1.93449664
47MP0005310_abnormal_salivary_gland1.87896234
48MP0003787_abnormal_imprinting1.87431838
49MP0001790_abnormal_immune_system1.86682923
50MP0005387_immune_system_phenotype1.86682923
51MP0009785_altered_susceptibility_to1.85241172
52MP0006292_abnormal_olfactory_placode1.84374114
53MP0004381_abnormal_hair_follicle1.83722755
54MP0000733_abnormal_muscle_development1.78463998
55MP0002132_abnormal_respiratory_system1.70823606
56MP0003724_increased_susceptibility_to1.70328689
57MP0000566_synostosis1.69914737
58MP0004484_altered_response_of1.68492256
59MP0002277_abnormal_respiratory_mucosa1.65958283
60MP0005000_abnormal_immune_tolerance1.65682148
61MP0001800_abnormal_humoral_immune1.65063191
62MP0000015_abnormal_ear_pigmentation1.64749531
63MP0003806_abnormal_nucleotide_metabolis1.64696880
64MP0004270_analgesia1.56002658
65MP0002398_abnormal_bone_marrow1.55448004
66MP0000013_abnormal_adipose_tissue1.53819917
67MP0005379_endocrine/exocrine_gland_phen1.53043873
68MP0000490_abnormal_crypts_of1.52359431
69MP0005266_abnormal_metabolism1.51575851
70MP0002452_abnormal_antigen_presenting1.51422359
71MP0008260_abnormal_autophagy1.51280125
72MP0005645_abnormal_hypothalamus_physiol1.49169188
73MP0002723_abnormal_immune_serum1.49155012
74MP0005025_abnormal_response_to1.49075100
75MP0005408_hypopigmentation1.47058695
76MP0001819_abnormal_immune_cell1.45683007
77MP0002127_abnormal_cardiovascular_syste1.44138659
78MP0002420_abnormal_adaptive_immunity1.43533357
79MP0002095_abnormal_skin_pigmentation1.39885945
80MP0002419_abnormal_innate_immunity1.35563273
81MP0005385_cardiovascular_system_phenoty1.35555328
82MP0001544_abnormal_cardiovascular_syste1.35555328
83MP0010630_abnormal_cardiac_muscle1.33965301
84MP0005171_absent_coat_pigmentation1.32890402
85MP0000716_abnormal_immune_system1.32428173
86MP0006138_congestive_heart_failure1.31744275
87MP0003950_abnormal_plasma_membrane1.27406646
88MP0004510_myositis1.24475240
89MP0009780_abnormal_chondrocyte_physiolo1.24443763
90MP0000372_irregular_coat_pigmentation1.24303210
91MP0000703_abnormal_thymus_morphology1.22638159
92MP0002405_respiratory_system_inflammati1.22177317
93MP0002006_tumorigenesis1.21690201
94MP0002722_abnormal_immune_system1.20244457
95MP0000689_abnormal_spleen_morphology1.19675937
96MP0004957_abnormal_blastocyst_morpholog1.17887111
97MP0005174_abnormal_tail_pigmentation1.14628967
98MP0006082_CNS_inflammation1.13576817
99MP0004808_abnormal_hematopoietic_stem1.10629616
100MP0002429_abnormal_blood_cell1.08971192
101MP0009764_decreased_sensitivity_to1.07434195
102MP0002166_altered_tumor_susceptibility1.07410001
103MP0003656_abnormal_erythrocyte_physiolo1.04893942
104MP0003221_abnormal_cardiomyocyte_apopto1.02698063
105MP0002971_abnormal_brown_adipose1.02499738
106MP0000383_abnormal_hair_follicle1.01748174
107MP0008775_abnormal_heart_ventricle1.01045835
108MP0001186_pigmentation_phenotype0.99154880
109MP0004147_increased_porphyrin_level0.97973941
110MP0003866_abnormal_defecation0.97850833
111MP0000371_diluted_coat_color0.97000406
112MP0002822_catalepsy0.96978786
113MP0008877_abnormal_DNA_methylation0.96692166
114MP0001986_abnormal_taste_sensitivity0.96047523
115MP0003137_abnormal_impulse_conducting0.95096382
116MP0001119_abnormal_female_reproductive0.94471299
117MP0002009_preneoplasia0.94084093
118MP0003436_decreased_susceptibility_to0.93681775
119MP0008932_abnormal_embryonic_tissue0.92467580
120MP0001529_abnormal_vocalization0.90032445
121MP0002160_abnormal_reproductive_system0.89231854
122MP0010307_abnormal_tumor_latency0.87378366
123MP0001661_extended_life_span0.85446989
124MP0004085_abnormal_heartbeat0.84449850
125MP0001873_stomach_inflammation0.82857897
126MP0003121_genomic_imprinting0.82824895
127MP0002019_abnormal_tumor_incidence0.79514940
128MP0004782_abnormal_surfactant_physiolog0.79008584
129MP0002075_abnormal_coat/hair_pigmentati0.78828028
130MP0001845_abnormal_inflammatory_respons0.77936370
131MP0001545_abnormal_hematopoietic_system0.77520668
132MP0005397_hematopoietic_system_phenotyp0.77520668
133MP0003879_abnormal_hair_cell0.77146602
134MP0004142_abnormal_muscle_tone0.76509758
135MP0003136_yellow_coat_color0.73855372
136MP0008789_abnormal_olfactory_epithelium0.73732647
137MP0000313_abnormal_cell_death0.72807893
138MP0005451_abnormal_body_composition0.72366514
139MP0001853_heart_inflammation0.72083412
140MP0000350_abnormal_cell_proliferation0.71556779
141MP0002638_abnormal_pupillary_reflex0.70931448
142MP0010155_abnormal_intestine_physiology0.65798444
143MP0004742_abnormal_vestibular_system0.65708700
144MP0000003_abnormal_adipose_tissue0.61672017
145MP0001485_abnormal_pinna_reflex0.61345057
146MP0002078_abnormal_glucose_homeostasis0.61324094
147MP0003045_fibrosis0.59869811
148MP0005375_adipose_tissue_phenotype0.59848992
149MP0003828_pulmonary_edema0.59573461
150MP0002928_abnormal_bile_duct0.59505984
151MP0005167_abnormal_blood-brain_barrier0.59320625
152MP0001764_abnormal_homeostasis0.58610507
153MP0000681_abnormal_thyroid_gland0.57175601
154MP0004185_abnormal_adipocyte_glucose0.55425020
155MP0000266_abnormal_heart_morphology0.54151549
156MP0004043_abnormal_pH_regulation0.53683775
157MP0001984_abnormal_olfaction0.53056205
158MP0009250_abnormal_appendicular_skeleto0.52611270
159MP0005666_abnormal_adipose_tissue0.51688079
160MP0009697_abnormal_copulation0.51298406
161MP0004134_abnormal_chest_morphology0.46633949
162MP0005332_abnormal_amino_acid0.45926310
163MP0002734_abnormal_mechanical_nocicepti0.45313192
164MP0005376_homeostasis/metabolism_phenot0.45161552
165MP0005187_abnormal_penis_morphology0.44198053
166MP0000230_abnormal_systemic_arterial0.40546924
167MP0008872_abnormal_physiological_respon0.39568268
168MP0005670_abnormal_white_adipose0.39157747
169MP0005452_abnormal_adipose_tissue0.37407710
170MP0006035_abnormal_mitochondrial_morpho0.34291721
171MP0000762_abnormal_tongue_morphology0.34237444
172MP0003315_abnormal_perineum_morphology0.34132685
173MP0001299_abnormal_eye_distance/0.34110256
174MP0005166_decreased_susceptibility_to0.33359686
175MP0005423_abnormal_somatic_nervous0.32354736
176MP0002272_abnormal_nervous_system0.32053493
177MP0002114_abnormal_axial_skeleton0.32045393
178MP0005535_abnormal_body_temperature0.31879791
179MP0006276_abnormal_autonomic_nervous0.30837329
180MP0005319_abnormal_enzyme/_coenzyme0.30347020
181MP0005334_abnormal_fat_pad0.29652588
182MP0010030_abnormal_orbit_morphology0.28665598
183MP0002128_abnormal_blood_circulation0.28624924
184MP0002067_abnormal_sensory_capabilities0.27443814
185MP0002066_abnormal_motor_capabilities/c0.27294447
186MP0005584_abnormal_enzyme/coenzyme_acti0.26236445
187MP0002249_abnormal_larynx_morphology0.22905695
188MP0001943_abnormal_respiration0.21611891

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)8.39006522
2Exercise-induced muscle cramps (HP:0003710)8.07839264
3Type 1 muscle fiber predominance (HP:0003803)7.69096609
4Muscle hypertrophy of the lower extremities (HP:0008968)6.83813544
5Calf muscle hypertrophy (HP:0008981)6.28114733
6Chromosomal breakage induced by crosslinking agents (HP:0003221)5.99583860
7Myopathic facies (HP:0002058)5.96985587
8Distal arthrogryposis (HP:0005684)5.77319152
9Chromsome breakage (HP:0040012)5.65255541
10EMG: myopathic abnormalities (HP:0003458)5.46384681
11Hyporeflexia of lower limbs (HP:0002600)5.05134287
12Abnormality of the calf musculature (HP:0001430)4.94788077
13Rhabdomyolysis (HP:0003201)4.77150810
14Myoglobinuria (HP:0002913)4.74651574
15Rimmed vacuoles (HP:0003805)4.70957471
16Neck muscle weakness (HP:0000467)4.63490007
17Muscle fiber splitting (HP:0003555)4.52716904
18Centrally nucleated skeletal muscle fibers (HP:0003687)4.47388072
19Round ear (HP:0100830)4.31797206
20Abnormality of the left ventricular outflow tract (HP:0011103)4.26848937
21Subaortic stenosis (HP:0001682)4.26848937
22Increased IgM level (HP:0003496)4.12541888
23Abnormality of skeletal muscle fiber size (HP:0012084)4.07284834
24Ulnar deviation of the wrist (HP:0003049)4.01934012
25Muscle stiffness (HP:0003552)3.86803408
26Abnormality of the preputium (HP:0100587)3.83396323
27Abnormality of chromosome stability (HP:0003220)3.75763166
28Meckel diverticulum (HP:0002245)3.71740276
29Abnormality of the ileum (HP:0001549)3.64252930
30Aplasia/Hypoplasia of the uvula (HP:0010293)3.61486665
31Calcaneovalgus deformity (HP:0001848)3.56955258
32Difficulty running (HP:0009046)3.52109247
33Abnormal delayed hypersensitivity skin test (HP:0002963)3.50726768
34Birth length less than 3rd percentile (HP:0003561)3.49011863
35Frequent falls (HP:0002359)3.42492865
36Increased variability in muscle fiber diameter (HP:0003557)3.39817004
37Absent phalangeal crease (HP:0006109)3.39615929
38Sudden death (HP:0001699)3.39142757
39Areflexia of lower limbs (HP:0002522)3.36252375
40Myotonia (HP:0002486)3.28398673
41Malignant hyperthermia (HP:0002047)3.27500510
42Asymmetric septal hypertrophy (HP:0001670)3.26850565
43Clubbing of toes (HP:0100760)3.23189678
44Oral leukoplakia (HP:0002745)3.20112408
45Deformed tarsal bones (HP:0008119)3.17826891
46Aplastic anemia (HP:0001915)3.16665726
47Bone marrow hypocellularity (HP:0005528)3.10702073
48Distal lower limb muscle weakness (HP:0009053)3.09482270
49Optic neuritis (HP:0100653)3.07081784
50Retrobulbar optic neuritis (HP:0100654)3.07081784
51Eczematoid dermatitis (HP:0000976)3.01471122
52Generalized muscle weakness (HP:0003324)2.94505095
53Weak cry (HP:0001612)2.90643989
54Scapular winging (HP:0003691)2.86157598
55Increased connective tissue (HP:0009025)2.85165985
56Panhypogammaglobulinemia (HP:0003139)2.85126187
57Duodenal stenosis (HP:0100867)2.84090786
58Small intestinal stenosis (HP:0012848)2.84090786
59Bulbar palsy (HP:0001283)2.83872215
60Abnormality of DNA repair (HP:0003254)2.80815263
61Abnormal finger flexion creases (HP:0006143)2.80743376
62EMG: neuropathic changes (HP:0003445)2.74708991
63Abnormality of T cell physiology (HP:0011840)2.71076044
64Myelodysplasia (HP:0002863)2.67546832
65Recurrent fungal infections (HP:0002841)2.66155729
66Duplicated collecting system (HP:0000081)2.65450650
67Lymphoma (HP:0002665)2.62412969
68Premature graying of hair (HP:0002216)2.61908519
69Granulocytopenia (HP:0001913)2.61532504
70Eosinophilia (HP:0001880)2.60618081
71IgG deficiency (HP:0004315)2.59486633
72Fetal akinesia sequence (HP:0001989)2.58334063
73Abnormality of the heme biosynthetic pathway (HP:0010472)2.57856155
74Limb-girdle muscle atrophy (HP:0003797)2.57407869
75Generalized hypopigmentation of hair (HP:0011358)2.57136520
76Mediastinal lymphadenopathy (HP:0100721)2.56812205
77Pulmonary fibrosis (HP:0002206)2.56731121
78Bundle branch block (HP:0011710)2.55571296
79Proximal amyotrophy (HP:0007126)2.54852745
80Impulsivity (HP:0100710)2.54618527
81Abnormality of the neuromuscular junction (HP:0003398)2.52004521
82Fatigable weakness (HP:0003473)2.52004521
83Stomach cancer (HP:0012126)2.47218260
84Dilated cardiomyopathy (HP:0001644)2.47151739
85Nephroblastoma (Wilms tumor) (HP:0002667)2.46748689
86Type 2 muscle fiber atrophy (HP:0003554)2.45221672
87Abnormality of the shoulder girdle musculature (HP:0001435)2.45157997
88Rough bone trabeculation (HP:0100670)2.43755703
89Spinal rigidity (HP:0003306)2.41680651
90Vasculitis (HP:0002633)2.38857641
91Selective tooth agenesis (HP:0001592)2.37386919
92Gowers sign (HP:0003391)2.35389309
93Abnormality of the renal collecting system (HP:0004742)2.34898599
94Fair hair (HP:0002286)2.34106863
95Pancytopenia (HP:0001876)2.32887224
96Muscular dystrophy (HP:0003560)2.29511793
97Autoimmune thrombocytopenia (HP:0001973)2.29148266
98Prostate neoplasm (HP:0100787)2.28812390
99Hyperkalemia (HP:0002153)2.27830464
100Neoplasm of the tracheobronchial system (HP:0100552)2.27481930
101Embryonal renal neoplasm (HP:0011794)2.26380022
102Mildly elevated creatine phosphokinase (HP:0008180)2.24991741
103Abnormality of T cells (HP:0002843)2.24816833
104Abnormality of T cell number (HP:0011839)2.24290432
105Abnormality of eosinophils (HP:0001879)2.23747508
106Myositis (HP:0100614)2.23315957
107Syringomyelia (HP:0003396)2.21139217
108Spinal cord lesions (HP:0100561)2.21139217
109Alveolar cell carcinoma (HP:0006519)2.21102402
110Orchitis (HP:0100796)2.20674043
111Encephalitis (HP:0002383)2.20303119
112Obstructive lung disease (HP:0006536)2.17102666
113Chronic obstructive pulmonary disease (HP:0006510)2.17102666
114Muscle fiber atrophy (HP:0100295)2.16612866
115Hypochromic anemia (HP:0001931)2.16204933
116Aplasia/Hypoplasia of the sacrum (HP:0008517)2.15986920
117Progressive muscle weakness (HP:0003323)2.15833062
118Ectopic kidney (HP:0000086)2.15503192
119Patellar aplasia (HP:0006443)2.15339760
120Periodontitis (HP:0000704)2.15012159
121Leukopenia (HP:0001882)2.13232328
122Lipoatrophy (HP:0100578)2.12475447
123Recurrent abscess formation (HP:0002722)2.12419365
124Stomatitis (HP:0010280)2.12271627
125Breast hypoplasia (HP:0003187)2.11524473
126Hypergammaglobulinemia (HP:0010702)2.08649317
127Recurrent cutaneous fungal infections (HP:0011370)2.08566454
128Chronic mucocutaneous candidiasis (HP:0002728)2.08566454
129Severe combined immunodeficiency (HP:0004430)2.08546392
130Keratoconjunctivitis (HP:0001096)2.06795189
131Abnormality of the duodenum (HP:0002246)2.06549667
132Nonprogressive disorder (HP:0003680)2.06155693
133Meningitis (HP:0001287)2.05689137
134Distal lower limb amyotrophy (HP:0008944)2.05570227
135Respiratory insufficiency due to muscle weakness (HP:0002747)2.04926220
136IgA deficiency (HP:0002720)2.03375430
137Abnormality of the foot musculature (HP:0001436)2.03085131
138Slender build (HP:0001533)2.02636004
139Abnormal spermatogenesis (HP:0008669)2.01883962
140True hermaphroditism (HP:0010459)2.01491148
141Exercise intolerance (HP:0003546)2.00161232
142Muscle fiber inclusion bodies (HP:0100299)10.7039580
143Nemaline bodies (HP:0003798)10.4220981
144Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)10.3665491
145Popliteal pterygium (HP:0009756)1.98528616
146Abnormality of the carotid arteries (HP:0005344)1.97519123
147IgM deficiency (HP:0002850)1.97360694
148Triphalangeal thumb (HP:0001199)1.96468063
149Basal ganglia calcification (HP:0002135)1.96361653
150Aplasia/Hypoplasia of the patella (HP:0006498)1.95014113
151Waddling gait (HP:0002515)1.94868590
152Abnormality of cells of the lymphoid lineage (HP:0012140)1.94523783
153Hip contracture (HP:0003273)1.93264569
154Abnormality of the prostate (HP:0008775)1.91667566
155Prolonged neonatal jaundice (HP:0006579)1.91011158
156Abnormality of the labia minora (HP:0012880)1.90966603
157Sloping forehead (HP:0000340)1.89953848
158Leukocytosis (HP:0001974)1.89782936
159Abnormality of the columella (HP:0009929)1.89315302
160Tracheoesophageal fistula (HP:0002575)1.88988862
161Hypopigmented skin patches (HP:0001053)1.88915036
162Chronic otitis media (HP:0000389)1.88512723
163Foot dorsiflexor weakness (HP:0009027)1.87164034
164Recurrent viral infections (HP:0004429)1.87010898
165Abnormal trabecular bone morphology (HP:0100671)1.86318389
166Neutropenia (HP:0001875)1.84852111
167Abnormal hair whorl (HP:0010721)1.84657496
168Cleft eyelid (HP:0000625)1.84280624
169Abnormality of the calcaneus (HP:0008364)1.84089032
170Keratoconjunctivitis sicca (HP:0001097)1.83502009
171Facial diplegia (HP:0001349)1.82128075
172Increased intramyocellular lipid droplets (HP:0012240)1.81542650
173Ventricular tachycardia (HP:0004756)1.79731254
174Abnormality of the musculature of the pelvis (HP:0001469)1.73066229
175Abnormality of the hip-girdle musculature (HP:0001445)1.73066229
176Difficulty climbing stairs (HP:0003551)1.71975587
177Increased muscle lipid content (HP:0009058)1.71781403
178Shoulder girdle muscle weakness (HP:0003547)1.67576476
179Heart block (HP:0012722)1.64434554
180Pelvic girdle muscle weakness (HP:0003749)1.59391983
181Limb-girdle muscle weakness (HP:0003325)1.58366881
182Ventricular arrhythmia (HP:0004308)1.58186082
183Ulnar deviation of finger (HP:0009465)1.57901554
184Diaphragmatic weakness (HP:0009113)1.52034968
185Ragged-red muscle fibers (HP:0003200)1.50042262
186Abnormal atrioventricular conduction (HP:0005150)1.48060501
187Lower limb amyotrophy (HP:0007210)1.47932166
188Long clavicles (HP:0000890)1.47762981
189Amniotic constriction ring (HP:0009775)1.45414433
190Abnormality of placental membranes (HP:0011409)1.45414433
191Paralysis (HP:0003470)1.44114621
192Easy fatigability (HP:0003388)1.42961309
193Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.39559593
194Abnormal mitochondria in muscle tissue (HP:0008316)1.39145697
195Large for gestational age (HP:0001520)1.38754405
196Acute necrotizing encephalopathy (HP:0006965)1.37898384
197Short palpebral fissure (HP:0012745)1.36083334
198Steppage gait (HP:0003376)1.34280473

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PHKG15.92065270
2PHKG25.92065270
3TTN5.01739265
4MAP3K144.35133338
5BRSK23.18469166
6TXK2.90563648
7STK162.90224524
8ZAK2.62794538
9PIK3CG2.59836475
10BUB12.51808691
11AKT32.34410469
12SRPK12.34258813
13MUSK2.21336574
14MKNK22.19222193
15EIF2AK12.16336354
16IRAK32.14294808
17TSSK62.07042535
18OBSCN10.8003734
19WEE11.97835813
20EPHA31.94816756
21MAPKAPK31.89191414
22JAK31.86838041
23MKNK11.79796780
24CDK31.77359398
25NME11.76991988
26MAPK121.74093945
27PIM21.67243253
28EIF2AK21.65072331
29NEK61.62039965
30BCR1.58942910
31YES11.56788949
32MAP2K71.56572046
33PLK31.53386279
34BMPR1B1.50811835
35MAP4K11.50434096
36IKBKB1.50114376
37MAP3K71.44880001
38TNIK1.44709386
39IRAK41.41151503
40CHUK1.38551629
41PASK1.37904269
42EIF2AK31.33847946
43BRSK11.26442699
44SIK31.20764690
45MAP2K31.19835834
46MARK31.18915098
47VRK11.16671025
48ATR1.15486160
49TEC1.13562540
50NME21.13366471
51NLK1.12478731
52PLK11.10832513
53MAP2K41.06160998
54CCNB10.97976301
55PIM10.95791224
56CASK0.95395669
57PLK40.93235037
58BRAF0.92632859
59MARK10.91747282
60MOS0.90920124
61ZAP700.88209230
62TYK20.88168886
63NUAK10.88047640
64BCKDK0.87814834
65IKBKE0.86963024
66PRKAA20.86924164
67TTK0.86629449
68SGK20.84608068
69DMPK0.84336210
70NEK20.84130368
71NTRK20.83875535
72CDK80.82036297
73MAPK150.81605937
74AURKB0.79524047
75FRK0.78408904
76CHEK20.77524072
77TIE10.77203162
78ERBB30.77154633
79PRPF4B0.76900536
80CAMK2G0.75709381
81ACVR1B0.75506301
82MAPK130.74448570
83STK40.74232950
84PDK20.73022951
85PKN10.69565895
86BMPR20.68865990
87KIT0.68764514
88AKT20.67523639
89EEF2K0.65661521
90LIMK10.64511503
91NEK90.63996527
92CDC70.63423094
93PRKAA10.63316285
94CHEK10.63224027
95MAPKAPK50.61545816
96TRPM70.60781372
97PRKG10.60759365
98LYN0.60517978
99MAP3K130.59227639
100KSR20.56857186
101IRAK10.56820421
102CLK10.56710773
103ATM0.55900997
104DYRK1B0.55116513
105FGFR40.54792134
106HCK0.54718599
107DYRK20.54621944
108LCK0.51978015
109CAMK40.51914729
110NEK10.51777085
111MAP3K40.50118938
112MAP3K10.49800067
113PINK10.49662102
114MAP2K10.49434490
115GRK10.48082453
116PRKCQ0.47333076
117ALK0.47291092
118MAPK70.46848622
119CAMK2D0.46542452
120BTK0.46496179
121SYK0.46402642
122TGFBR10.46147900
123EPHB10.46032163
124ROCK10.44618948
125CAMK2A0.44535235
126SGK30.42751104
127CDK40.41699955
128RPS6KB10.39723907
129CSNK1A1L0.39641461
130MAP2K60.38806609
131RPS6KA40.38518771
132CAMK10.38111137
133CSK0.38001132
134PRKACA0.37417382
135JAK10.37109045
136CDK20.36837124
137CSNK2A10.35271592
138SGK4940.35009239
139SGK2230.35009239
140PIK3CA0.34970012
141MAPK40.34232828
142SGK10.33934599
143ADRBK20.33375424
144CDK70.32777446
145RAF10.32632653
146PRKD30.31562525
147KSR10.30610121
148PAK60.29853921
149MAPK110.29204228
150PRKACB0.28175507
151CAMK2B0.28125093
152MAP3K90.27498717
153DAPK20.26957743
154RPS6KA10.26337157
155STK390.26281426
156RPS6KA30.24229094
157ARAF0.23330880
158LATS20.22435669
159LATS10.20485837
160WNK40.20400347
161DYRK30.15489092
162INSRR0.15367528
163MAP4K20.14968730
164WNK30.13387010
165MAPK100.12888553
166OXSR10.12565147
167STK38L0.12280515
168RPS6KA60.12175152
169TNK20.12164665
170PAK30.12038564
171RPS6KB20.11923982
172ADRBK10.11754776
173PRKACG0.09981387
174PRKG20.09793262
175RPS6KL10.08698912
176RPS6KC10.08698912

Predicted pathways (KEGG)

RankGene SetZ-score
1Cardiac muscle contraction_Homo sapiens_hsa042604.52681268
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.28374396
3Dilated cardiomyopathy_Homo sapiens_hsa054143.69691629
4DNA replication_Homo sapiens_hsa030303.28984243
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.27880198
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.10836908
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.96943661
8Allograft rejection_Homo sapiens_hsa053302.78267196
9Mismatch repair_Homo sapiens_hsa034302.72368085
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.68191851
11Parkinsons disease_Homo sapiens_hsa050122.59205274
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.55972979
13Fanconi anemia pathway_Homo sapiens_hsa034602.49355298
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.44850097
15Vitamin B6 metabolism_Homo sapiens_hsa007502.43854583
16RNA polymerase_Homo sapiens_hsa030202.42806140
17Autoimmune thyroid disease_Homo sapiens_hsa053202.40769860
18Homologous recombination_Homo sapiens_hsa034402.36176440
19NF-kappa B signaling pathway_Homo sapiens_hsa040642.35711720
20Oxidative phosphorylation_Homo sapiens_hsa001902.35121851
21Graft-versus-host disease_Homo sapiens_hsa053322.34797586
22Primary immunodeficiency_Homo sapiens_hsa053402.33765270
23Glucagon signaling pathway_Homo sapiens_hsa049222.28197994
24Base excision repair_Homo sapiens_hsa034102.22017695
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.18964714
26One carbon pool by folate_Homo sapiens_hsa006702.18049651
27Arginine and proline metabolism_Homo sapiens_hsa003302.09820322
28Alzheimers disease_Homo sapiens_hsa050102.07320983
29Proteasome_Homo sapiens_hsa030502.06228835
30Propanoate metabolism_Homo sapiens_hsa006402.03424821
31Cell cycle_Homo sapiens_hsa041102.01598051
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.99761439
33Non-homologous end-joining_Homo sapiens_hsa034501.96858187
34Nucleotide excision repair_Homo sapiens_hsa034201.93692917
35Oxytocin signaling pathway_Homo sapiens_hsa049211.90408363
36p53 signaling pathway_Homo sapiens_hsa041151.86336464
37Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.85341579
38Nitrogen metabolism_Homo sapiens_hsa009101.83649564
39Pyruvate metabolism_Homo sapiens_hsa006201.83397017
40Calcium signaling pathway_Homo sapiens_hsa040201.82710164
41Basal transcription factors_Homo sapiens_hsa030221.82079644
42Carbon metabolism_Homo sapiens_hsa012001.79593339
43Measles_Homo sapiens_hsa051621.74405386
44Spliceosome_Homo sapiens_hsa030401.72483106
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.72481295
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.70760914
47Insulin signaling pathway_Homo sapiens_hsa049101.70053145
48Arginine biosynthesis_Homo sapiens_hsa002201.69443273
49Pyrimidine metabolism_Homo sapiens_hsa002401.63754112
50NOD-like receptor signaling pathway_Homo sapiens_hsa046211.60294214
51Fructose and mannose metabolism_Homo sapiens_hsa000511.59572520
52Herpes simplex infection_Homo sapiens_hsa051681.59255712
53Fatty acid degradation_Homo sapiens_hsa000711.56000120
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.53038870
55RNA transport_Homo sapiens_hsa030131.52489470
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.44758235
57cGMP-PKG signaling pathway_Homo sapiens_hsa040221.43344279
58RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.40283400
59Insulin resistance_Homo sapiens_hsa049311.38446647
60Type I diabetes mellitus_Homo sapiens_hsa049401.32241377
61Asthma_Homo sapiens_hsa053101.31280341
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.29724898
63Huntingtons disease_Homo sapiens_hsa050161.27110845
64Epstein-Barr virus infection_Homo sapiens_hsa051691.26538780
65Butanoate metabolism_Homo sapiens_hsa006501.26367291
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.24719056
67Starch and sucrose metabolism_Homo sapiens_hsa005001.20482476
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.19071810
69Hematopoietic cell lineage_Homo sapiens_hsa046401.18318866
70AMPK signaling pathway_Homo sapiens_hsa041521.17548237
71Vascular smooth muscle contraction_Homo sapiens_hsa042701.16194735
72Legionellosis_Homo sapiens_hsa051341.15772255
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.15446825
74Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.14036092
75Regulation of autophagy_Homo sapiens_hsa041401.08578975
76Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.07116899
77RNA degradation_Homo sapiens_hsa030181.06001858
78Leishmaniasis_Homo sapiens_hsa051401.04974949
79Apoptosis_Homo sapiens_hsa042101.04825607
80Toll-like receptor signaling pathway_Homo sapiens_hsa046201.04008177
81Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.02282140
82Antigen processing and presentation_Homo sapiens_hsa046121.02140108
83Purine metabolism_Homo sapiens_hsa002300.98343301
84Fatty acid metabolism_Homo sapiens_hsa012120.97643376
85TNF signaling pathway_Homo sapiens_hsa046680.97266596
86Gastric acid secretion_Homo sapiens_hsa049710.93080650
87Influenza A_Homo sapiens_hsa051640.92744330
88Jak-STAT signaling pathway_Homo sapiens_hsa046300.92672891
89T cell receptor signaling pathway_Homo sapiens_hsa046600.91532393
90Arachidonic acid metabolism_Homo sapiens_hsa005900.91006921
91Renin secretion_Homo sapiens_hsa049240.89066340
92mRNA surveillance pathway_Homo sapiens_hsa030150.88995856
93Biosynthesis of amino acids_Homo sapiens_hsa012300.87391987
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.83190889
95Vitamin digestion and absorption_Homo sapiens_hsa049770.82948403
96Hepatitis B_Homo sapiens_hsa051610.81870764
97Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.80537211
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79352512
99Rheumatoid arthritis_Homo sapiens_hsa053230.78142102
100Peroxisome_Homo sapiens_hsa041460.75558691
101Phenylalanine metabolism_Homo sapiens_hsa003600.75409965
102Olfactory transduction_Homo sapiens_hsa047400.74994024
103beta-Alanine metabolism_Homo sapiens_hsa004100.72650843
104African trypanosomiasis_Homo sapiens_hsa051430.72155435
105Viral carcinogenesis_Homo sapiens_hsa052030.69836602
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.69721262
107Tight junction_Homo sapiens_hsa045300.69701764
108Ribosome_Homo sapiens_hsa030100.68347529
109Insulin secretion_Homo sapiens_hsa049110.67961555
110Phototransduction_Homo sapiens_hsa047440.66118588
111Osteoclast differentiation_Homo sapiens_hsa043800.66028662
112Malaria_Homo sapiens_hsa051440.64752108
113SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64069107
114Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62085981
115Circadian entrainment_Homo sapiens_hsa047130.60575970
116Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.58732668
117Tuberculosis_Homo sapiens_hsa051520.58460573
118Tryptophan metabolism_Homo sapiens_hsa003800.58311878
119Toxoplasmosis_Homo sapiens_hsa051450.58287281
120HTLV-I infection_Homo sapiens_hsa051660.57603203
121Maturity onset diabetes of the young_Homo sapiens_hsa049500.57513645
122Folate biosynthesis_Homo sapiens_hsa007900.53968969
123Small cell lung cancer_Homo sapiens_hsa052220.53154760
124Ether lipid metabolism_Homo sapiens_hsa005650.53125793
125Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.52929197
126Pertussis_Homo sapiens_hsa051330.52102407
127FoxO signaling pathway_Homo sapiens_hsa040680.51156288
128Chemokine signaling pathway_Homo sapiens_hsa040620.50969115
129Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50953518
130Salivary secretion_Homo sapiens_hsa049700.49174896
131Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46663341
132Sphingolipid metabolism_Homo sapiens_hsa006000.45961915
133Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44998403
134PPAR signaling pathway_Homo sapiens_hsa033200.44900387
135Cyanoamino acid metabolism_Homo sapiens_hsa004600.44526408
136Fatty acid elongation_Homo sapiens_hsa000620.43389737
137Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42294764
138GnRH signaling pathway_Homo sapiens_hsa049120.41666431
139Nicotine addiction_Homo sapiens_hsa050330.41620412
140Aldosterone synthesis and secretion_Homo sapiens_hsa049250.41274859
141Long-term potentiation_Homo sapiens_hsa047200.39874058
142Long-term depression_Homo sapiens_hsa047300.39506803
143Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39416998
144MAPK signaling pathway_Homo sapiens_hsa040100.39015018
145Sulfur relay system_Homo sapiens_hsa041220.36808371
146* Metabolic pathways_Homo sapiens_hsa011000.36214428
147Hepatitis C_Homo sapiens_hsa051600.36092213
148Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.33232420
149Viral myocarditis_Homo sapiens_hsa054160.32316025
150Drug metabolism - other enzymes_Homo sapiens_hsa009830.31908094
151Linoleic acid metabolism_Homo sapiens_hsa005910.31831327
152cAMP signaling pathway_Homo sapiens_hsa040240.31775441
153Cholinergic synapse_Homo sapiens_hsa047250.30702578
154Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29679793
155Glutathione metabolism_Homo sapiens_hsa004800.29526662
156MicroRNAs in cancer_Homo sapiens_hsa052060.29074026
157Pentose phosphate pathway_Homo sapiens_hsa000300.27692598
158Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27621750
159Acute myeloid leukemia_Homo sapiens_hsa052210.27609425
160Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.27510936
161Circadian rhythm_Homo sapiens_hsa047100.26881779
162Histidine metabolism_Homo sapiens_hsa003400.25458855
163Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.25080831
164Thyroid hormone signaling pathway_Homo sapiens_hsa049190.24683852
165Shigellosis_Homo sapiens_hsa051310.24466907
166Systemic lupus erythematosus_Homo sapiens_hsa053220.24179522
167Prostate cancer_Homo sapiens_hsa052150.21718831
168Protein export_Homo sapiens_hsa030600.20950884
169Focal adhesion_Homo sapiens_hsa045100.20877769
170Cysteine and methionine metabolism_Homo sapiens_hsa002700.19627067
171Prolactin signaling pathway_Homo sapiens_hsa049170.19406467
172GABAergic synapse_Homo sapiens_hsa047270.19295811
173Ovarian steroidogenesis_Homo sapiens_hsa049130.19019514
174Tyrosine metabolism_Homo sapiens_hsa003500.18822293
175alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.18708031
176Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.17281709
177Galactose metabolism_Homo sapiens_hsa000520.17105071
178Melanogenesis_Homo sapiens_hsa049160.16332561
179Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.15998488
180Amphetamine addiction_Homo sapiens_hsa050310.15953926
181Hedgehog signaling pathway_Homo sapiens_hsa043400.15505530
182Mineral absorption_Homo sapiens_hsa049780.13396782
183Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.11603072
184Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.11465263
185Dopaminergic synapse_Homo sapiens_hsa047280.10501927
186ABC transporters_Homo sapiens_hsa020100.09602098
187Pancreatic secretion_Homo sapiens_hsa049720.09298614

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