IDNK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular anion homeostasis (GO:0030002)5.63894547
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.56035406
3cytidine deamination (GO:0009972)5.42630282
4cytidine metabolic process (GO:0046087)5.42630282
5cytidine catabolic process (GO:0006216)5.42630282
6pyrimidine ribonucleoside catabolic process (GO:0046133)4.74089420
7necroptotic process (GO:0070266)4.31103513
8water-soluble vitamin biosynthetic process (GO:0042364)4.21650429
9cellular ketone body metabolic process (GO:0046950)4.20515747
10secondary heart field specification (GO:0003139)4.07929675
11heart field specification (GO:0003128)4.07929675
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.05617562
13fucose catabolic process (GO:0019317)4.04931828
14L-fucose metabolic process (GO:0042354)4.04931828
15L-fucose catabolic process (GO:0042355)4.04931828
16positive regulation of fibroblast migration (GO:0010763)3.99726955
17positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.98878903
18drug catabolic process (GO:0042737)3.98217086
19ribosomal small subunit assembly (GO:0000028)3.87727225
20exogenous drug catabolic process (GO:0042738)3.78744640
21ketone body metabolic process (GO:1902224)3.78569707
22behavioral response to nicotine (GO:0035095)3.66652615
23mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.65284406
24ATP synthesis coupled proton transport (GO:0015986)3.64796020
25energy coupled proton transport, down electrochemical gradient (GO:0015985)3.64796020
26regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.63573206
27antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.57447197
28positive regulation of cell fate commitment (GO:0010455)3.56804056
29sequestering of actin monomers (GO:0042989)3.56030175
30positive regulation of defense response to virus by host (GO:0002230)3.55669338
31regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.55449167
32respiratory electron transport chain (GO:0022904)3.53055942
33positive regulation of interleukin-17 production (GO:0032740)3.47631106
34electron transport chain (GO:0022900)3.44598989
35growth hormone receptor signaling pathway (GO:0060396)3.44376997
36alkaloid metabolic process (GO:0009820)3.43439201
37somite rostral/caudal axis specification (GO:0032525)3.39911319
38neutrophil activation involved in immune response (GO:0002283)3.39272649
39platelet dense granule organization (GO:0060155)3.38497014
40epoxygenase P450 pathway (GO:0019373)3.31351054
41regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.30005117
42protein complex biogenesis (GO:0070271)3.29203942
43oxidative demethylation (GO:0070989)3.26110119
44intracellular pH reduction (GO:0051452)3.25906804
45protein neddylation (GO:0045116)3.22634205
46signal peptide processing (GO:0006465)3.15144826
47aldehyde catabolic process (GO:0046185)3.14253248
48viral transcription (GO:0019083)3.12616822
49proteasome assembly (GO:0043248)3.12277674
50mitochondrial respiratory chain complex I assembly (GO:0032981)3.09818718
51NADH dehydrogenase complex assembly (GO:0010257)3.09818718
52mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.09818718
53chaperone-mediated protein transport (GO:0072321)3.09427471
54ribosomal small subunit biogenesis (GO:0042274)3.08570823
55positive regulation of prostaglandin secretion (GO:0032308)3.07384492
56type I interferon signaling pathway (GO:0060337)3.06533270
57cellular response to type I interferon (GO:0071357)3.06533270
58sleep (GO:0030431)3.06338112
59cellular response to interferon-beta (GO:0035458)3.05618743
60negative regulation of myeloid cell apoptotic process (GO:0033033)3.04440513
61respiratory chain complex IV assembly (GO:0008535)3.04137573
62cellular response to growth hormone stimulus (GO:0071378)3.03235001
63pyrimidine nucleoside catabolic process (GO:0046135)3.01591331
64cotranslational protein targeting to membrane (GO:0006613)3.00933822
65response to type I interferon (GO:0034340)2.98819016
66cytochrome complex assembly (GO:0017004)2.98032727
67SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.97055434
68response to interferon-beta (GO:0035456)2.95121898
69programmed necrotic cell death (GO:0097300)2.94889025
70translational termination (GO:0006415)2.94571962
71antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.93843608
72antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.93693051
73erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.93143273
74L-phenylalanine catabolic process (GO:0006559)2.93143273
75adaptation of signaling pathway (GO:0023058)2.93042536
76protein targeting to ER (GO:0045047)2.92725949
77respiratory burst (GO:0045730)2.92668503
78negative regulation of telomere maintenance (GO:0032205)2.91476651
79positive regulation of endothelial cell apoptotic process (GO:2000353)2.90793848
80regulation of mesoderm development (GO:2000380)2.88305369
81positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.87993766
82positive regulation of gamma-delta T cell activation (GO:0046645)2.85912735
83protein localization to endoplasmic reticulum (GO:0070972)2.83905318
84DNA deamination (GO:0045006)2.83880263
85T cell apoptotic process (GO:0070231)2.83274626
86negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.82756783
87mitochondrial respiratory chain complex assembly (GO:0033108)2.82654047
88positive regulation of fatty acid transport (GO:2000193)2.80767210
89positive regulation of alpha-beta T cell proliferation (GO:0046641)2.78202233
90necrotic cell death (GO:0070265)2.77809649
91negative regulation of cell fate specification (GO:0009996)2.77071932
92aggressive behavior (GO:0002118)2.77029613
93positive regulation of antigen processing and presentation (GO:0002579)2.75030110
94omega-hydroxylase P450 pathway (GO:0097267)2.74700362
95inositol phosphate catabolic process (GO:0071545)2.73697676
96establishment of protein localization to endoplasmic reticulum (GO:0072599)2.73547635
97T cell migration (GO:0072678)2.71817186
98regulation of neurotransmitter uptake (GO:0051580)2.71652399
99inositol phosphate dephosphorylation (GO:0046855)2.70063356
100phosphorylated carbohydrate dephosphorylation (GO:0046838)2.70063356
101purinergic nucleotide receptor signaling pathway (GO:0035590)2.69813564
102lymphocyte apoptotic process (GO:0070227)2.69705383
103cardiac ventricle formation (GO:0003211)2.68136915
104positive regulation of icosanoid secretion (GO:0032305)2.67480169
105positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)2.66661654
106regulation of metalloenzyme activity (GO:0048552)2.65630032
107regulation of antigen processing and presentation (GO:0002577)2.65242607
108dopamine transport (GO:0015872)2.65162487
109response to pheromone (GO:0019236)2.64417345
110pH reduction (GO:0045851)2.63063436
111specification of organ identity (GO:0010092)2.63052611
112regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.62613217
113mast cell activation (GO:0045576)2.62462580
114eosinophil chemotaxis (GO:0048245)2.61936394
115antigen processing and presentation of endogenous antigen (GO:0019883)2.61759162
116regulation of isotype switching to IgG isotypes (GO:0048302)2.61123095
117superoxide anion generation (GO:0042554)2.60651672
118aromatic amino acid family catabolic process (GO:0009074)2.60013530
119positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.59935683
120vitamin biosynthetic process (GO:0009110)2.58161583
121indolalkylamine metabolic process (GO:0006586)2.57638254
122regulation of alpha-beta T cell proliferation (GO:0046640)2.57500828
123positive regulation of protein homodimerization activity (GO:0090073)2.57388207
124signal transduction involved in regulation of gene expression (GO:0023019)2.57311595
125cell migration involved in heart development (GO:0060973)2.57034050
126reactive oxygen species biosynthetic process (GO:1903409)2.56721596
127positive regulation of T cell migration (GO:2000406)2.55326416
128regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.54518996
129positive regulation of humoral immune response (GO:0002922)2.54338096
130dendritic cell chemotaxis (GO:0002407)2.53847004
131NAD biosynthetic process (GO:0009435)2.53725133
132positive regulation of ERBB signaling pathway (GO:1901186)2.52684317
133positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.52345231
134positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.51683714
135regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.51683714
136regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.51601142
137negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.51559113
138positive regulation of DNA recombination (GO:0045911)2.51439515
139extrinsic apoptotic signaling pathway via death domain receptors (GO:0008625)2.51040666
140cytokine biosynthetic process (GO:0042089)2.50838770
141regulation of glucokinase activity (GO:0033131)2.50740953
142regulation of hexokinase activity (GO:1903299)2.50740953
143regulation of T cell migration (GO:2000404)2.49571651
144leukocyte aggregation (GO:0070486)2.49454113
145antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.48598432
146regulation of inflammatory response to antigenic stimulus (GO:0002861)2.48135591
147polyol catabolic process (GO:0046174)2.48068698
148GTP biosynthetic process (GO:0006183)2.47630371
149regulation of activation of Janus kinase activity (GO:0010533)2.47493980
150response to peptidoglycan (GO:0032494)2.47436190
151response to misfolded protein (GO:0051788)2.47065722
152positive regulation of calcium-mediated signaling (GO:0050850)2.46626211
153regulation of regulatory T cell differentiation (GO:0045589)2.46528383
154T-helper 1 type immune response (GO:0042088)2.46489360
155regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.46248719
156regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.46248719
157negative T cell selection (GO:0043383)2.46217564
158positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.45676893
159positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.44331679
160regulation of T-helper 1 cell differentiation (GO:0045625)2.44147513
161regulation of cellular amino acid metabolic process (GO:0006521)2.43279515
162preassembly of GPI anchor in ER membrane (GO:0016254)2.43145406
163positive regulation of B cell mediated immunity (GO:0002714)2.42574388
164positive regulation of immunoglobulin mediated immune response (GO:0002891)2.42574388
165positive regulation of T cell mediated cytotoxicity (GO:0001916)2.41912713
166ribosomal large subunit biogenesis (GO:0042273)2.41871612
167neutrophil activation (GO:0042119)2.40930308
168translational elongation (GO:0006414)2.38310392
169xenobiotic catabolic process (GO:0042178)2.38295035
170epithelial cilium movement (GO:0003351)2.37883800
171piRNA metabolic process (GO:0034587)2.37873528
172sulfation (GO:0051923)2.37636406
173axoneme assembly (GO:0035082)2.37503680
174interferon-gamma production (GO:0032609)2.37216972
175antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.35058038
176antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.35058038
177cellular response to interleukin-15 (GO:0071350)2.34684996
178negative regulation of viral genome replication (GO:0045071)2.34212626
179DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.33889296
180regulation of RIG-I signaling pathway (GO:0039535)2.33789423
181granulocyte activation (GO:0036230)2.33713325
182viral life cycle (GO:0019058)2.33642780
183negative thymic T cell selection (GO:0045060)2.33023619
184termination of RNA polymerase III transcription (GO:0006386)2.29705658
185transcription elongation from RNA polymerase III promoter (GO:0006385)2.29705658
186positive regulation of lymphocyte migration (GO:2000403)2.29347320
187hydrogen peroxide biosynthetic process (GO:0050665)2.29342587
188amyloid precursor protein catabolic process (GO:0042987)2.29087128
189eosinophil migration (GO:0072677)2.28747655
190signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.28370549

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.70852760
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.46384275
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.10300412
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.95122278
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.83981203
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.68965701
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.62052463
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.21444025
9ELF1_17652178_ChIP-ChIP_JURKAT_Human3.18999712
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.14561616
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.06743166
12GABP_17652178_ChIP-ChIP_JURKAT_Human3.01140327
13ZNF274_21170338_ChIP-Seq_K562_Hela2.99201519
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.86312646
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.81975947
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.71370081
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.68922305
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.60594168
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.47704561
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.45764327
21EGR1_23403033_ChIP-Seq_LIVER_Mouse2.41446669
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.40831305
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.25014467
24FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.20232432
25CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.10211830
26SRF_21415370_ChIP-Seq_HL-1_Mouse2.06666473
27PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.03146893
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.98707388
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.88896555
30GBX2_23144817_ChIP-Seq_PC3_Human1.82264631
31LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.81462179
32* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.78693769
33IRF8_27001747_Chip-Seq_BMDM_Mouse1.74215927
34EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.69552490
35ELK1_19687146_ChIP-ChIP_HELA_Human1.68080308
36EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.67709849
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.66711676
38VDR_23849224_ChIP-Seq_CD4+_Human1.63840545
39TP53_22573176_ChIP-Seq_HFKS_Human1.63025500
40CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.62397022
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.61653099
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.60588463
43CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.60346244
44ETS1_20019798_ChIP-Seq_JURKAT_Human1.58946428
45CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.57233824
46TAF15_26573619_Chip-Seq_HEK293_Human1.55031105
47SPI1_23547873_ChIP-Seq_NB4_Human1.54433192
48FOXA1_21572438_ChIP-Seq_LNCaP_Human1.52923028
49RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.51609382
50STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.50877558
51FOXA1_25329375_ChIP-Seq_VCAP_Human1.49308824
52FOXA1_27270436_Chip-Seq_PROSTATE_Human1.49308824
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.47483584
54STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.45700693
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45604309
56GATA3_21878914_ChIP-Seq_MCF-7_Human1.45211799
57CREB1_15753290_ChIP-ChIP_HEK293T_Human1.44283704
58SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.44098839
59MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.43803231
60PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.43116336
61ETV2_25802403_ChIP-Seq_MESCs_Mouse1.38177673
62FUS_26573619_Chip-Seq_HEK293_Human1.38059043
63STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.37086434
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.36555451
65IRF1_19129219_ChIP-ChIP_H3396_Human1.35638341
66FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.34712317
67NANOG_19829295_ChIP-Seq_ESCs_Human1.32597512
68SOX2_19829295_ChIP-Seq_ESCs_Human1.32597512
69TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.32243803
70TAF2_19829295_ChIP-Seq_ESCs_Human1.31660983
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31375334
72CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29853106
73HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.27080242
74FOXP3_21729870_ChIP-Seq_TREG_Human1.24165497
75AR_20517297_ChIP-Seq_VCAP_Human1.20759913
76ELK1_22589737_ChIP-Seq_MCF10A_Human1.18965566
77ERG_20887958_ChIP-Seq_HPC-7_Mouse1.18778755
78NCOR_22424771_ChIP-Seq_293T_Human1.18598007
79BMI1_23680149_ChIP-Seq_NPCS_Mouse1.18384972
80GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.17681618
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17406810
82CBP_20019798_ChIP-Seq_JUKART_Human1.17406810
83CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.16514607
84NANOG_20526341_ChIP-Seq_ESCs_Human1.15976918
85DCP1A_22483619_ChIP-Seq_HELA_Human1.15685960
86NFE2_27457419_Chip-Seq_LIVER_Mouse1.15042934
87BCAT_22108803_ChIP-Seq_LS180_Human1.14926131
88FOXH1_21741376_ChIP-Seq_EPCs_Human1.14321937
89PIAS1_25552417_ChIP-Seq_VCAP_Human1.14142178
90CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.13806469
91NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.13731699
92HOXB7_26014856_ChIP-Seq_BT474_Human1.13718005
93P53_21459846_ChIP-Seq_SAOS-2_Human1.13360824
94EWS_26573619_Chip-Seq_HEK293_Human1.12640141
95GATA3_27048872_Chip-Seq_THYMUS_Human1.12226162
96LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10901259
97SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10832028
98ERA_21632823_ChIP-Seq_H3396_Human1.09382915
99YY1_21170310_ChIP-Seq_MESCs_Mouse1.09138110
100KAP1_22055183_ChIP-Seq_ESCs_Mouse1.09135099
101VDR_22108803_ChIP-Seq_LS180_Human1.07625341
102GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.07059903
103CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.06954166
104UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06932932
105PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06574399
106EZH2_27294783_Chip-Seq_NPCs_Mouse1.05338148
107PRDM14_20953172_ChIP-Seq_ESCs_Human1.05280358
108RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.04617705
109ERG_20517297_ChIP-Seq_VCAP_Human1.04469449
110MYC_19829295_ChIP-Seq_ESCs_Human1.03403424
111CDX2_22108803_ChIP-Seq_LS180_Human1.03001430
112MYC_18940864_ChIP-ChIP_HL60_Human1.02241715
113POU3F2_20337985_ChIP-ChIP_501MEL_Human1.01438813
114STAT3_18555785_Chip-Seq_ESCs_Mouse1.00534882
115CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99815510
116HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.99026001
117TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.98852639
118CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98347375
119OCT4_20526341_ChIP-Seq_ESCs_Human0.97084465
120AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97058032
121SMAD4_21799915_ChIP-Seq_A2780_Human0.96873990
122RUNX1_27457419_Chip-Seq_LIVER_Mouse0.96648371
123RUNX_20019798_ChIP-Seq_JUKART_Human0.96569114
124SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.96541386
125PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.95925060
126NMYC_18555785_Chip-Seq_ESCs_Mouse0.95724296
127GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95692077
128SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95319572
129GATA3_26560356_Chip-Seq_TH1_Human0.95311194
130REST_21632747_ChIP-Seq_MESCs_Mouse0.95297745
131TCF4_22108803_ChIP-Seq_LS180_Human0.95077262
132GATA3_26560356_Chip-Seq_TH2_Human0.94218442
133NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94188993
134EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.92934902
135MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92864683
136MYB_26560356_Chip-Seq_TH2_Human0.92715318
137EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.92091941
138CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92064676
139RBPJ_21746931_ChIP-Seq_IB4_Human0.91804642
140ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.88874073
141MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.87991326
142GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.87980220
143P53_22387025_ChIP-Seq_ESCs_Mouse0.87493255
144EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.87350549
145HTT_18923047_ChIP-ChIP_STHdh_Human0.86706032
146THAP11_20581084_ChIP-Seq_MESCs_Mouse0.86508713
147SMAD1_18555785_Chip-Seq_ESCs_Mouse0.86241289
148FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.84882303
149FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.84633421
150CRX_20693478_ChIP-Seq_RETINA_Mouse0.83858159
151P300_19829295_ChIP-Seq_ESCs_Human0.83483593
152IGF1R_20145208_ChIP-Seq_DFB_Human0.82565070
153SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.82054426
154ER_23166858_ChIP-Seq_MCF-7_Human0.81841789
155SCL_19346495_ChIP-Seq_HPC-7_Human0.81209174
156P300_18555785_Chip-Seq_ESCs_Mouse0.81135047

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.98092533
2MP0005671_abnormal_response_to3.41990165
3MP0003724_increased_susceptibility_to3.38642307
4MP0009785_altered_susceptibility_to3.35855098
5MP0002234_abnormal_pharynx_morphology3.33464816
6MP0002148_abnormal_hypersensitivity_rea3.17091480
7MP0002837_dystrophic_cardiac_calcinosis2.91464020
8MP0001873_stomach_inflammation2.65954227
9MP0005000_abnormal_immune_tolerance2.54721043
10MP0005025_abnormal_response_to2.48403398
11MP0000685_abnormal_immune_system2.41042902
12MP0005645_abnormal_hypothalamus_physiol2.40172773
13MP0009379_abnormal_foot_pigmentation2.37288988
14MP0005387_immune_system_phenotype2.36486541
15MP0001790_abnormal_immune_system2.36486541
16MP0005646_abnormal_pituitary_gland2.23976868
17MP0003436_decreased_susceptibility_to2.22434664
18MP0001800_abnormal_humoral_immune2.20830843
19MP0002723_abnormal_immune_serum2.15252569
20MP0002419_abnormal_innate_immunity2.10118829
21MP0006082_CNS_inflammation2.09966716
22MP0003787_abnormal_imprinting2.05364153
23MP0001986_abnormal_taste_sensitivity2.04902277
24MP0003763_abnormal_thymus_physiology1.99651501
25MP0002452_abnormal_antigen_presenting1.97205033
26MP0001819_abnormal_immune_cell1.95417657
27MP0002420_abnormal_adaptive_immunity1.95338109
28MP0004381_abnormal_hair_follicle1.91694640
29MP0008877_abnormal_DNA_methylation1.87453032
30MP0008872_abnormal_physiological_respon1.85851031
31MP0002163_abnormal_gland_morphology1.83877315
32MP0010386_abnormal_urinary_bladder1.81951671
33MP0000465_gastrointestinal_hemorrhage1.81291254
34MP0002876_abnormal_thyroid_physiology1.79023152
35MP0001529_abnormal_vocalization1.74561493
36MP0001905_abnormal_dopamine_level1.73970798
37MP0005451_abnormal_body_composition1.73419250
38MP0002132_abnormal_respiratory_system1.71607106
39MP0009333_abnormal_splenocyte_physiolog1.71100046
40MP0006276_abnormal_autonomic_nervous1.70333604
41MP0000013_abnormal_adipose_tissue1.69130165
42MP0005075_abnormal_melanosome_morpholog1.67452973
43MP0002693_abnormal_pancreas_physiology1.65495092
44MP0003136_yellow_coat_color1.61511109
45MP0003186_abnormal_redox_activity1.58851876
46MP0005551_abnormal_eye_electrophysiolog1.58530544
47MP0001188_hyperpigmentation1.58213233
48MP0002139_abnormal_hepatobiliary_system1.55958751
49MP0005379_endocrine/exocrine_gland_phen1.55884532
50MP0009764_decreased_sensitivity_to1.54499376
51MP0002277_abnormal_respiratory_mucosa1.53663042
52MP0009046_muscle_twitch1.53215900
53MP0000716_abnormal_immune_system1.51119972
54MP0009697_abnormal_copulation1.51085456
55MP0010329_abnormal_lipoprotein_level1.50030517
56MP0004043_abnormal_pH_regulation1.49974096
57MP0001853_heart_inflammation1.48846820
58MP0002166_altered_tumor_susceptibility1.48206265
59MP0002138_abnormal_hepatobiliary_system1.47762080
60MP0001764_abnormal_homeostasis1.47174064
61MP0006072_abnormal_retinal_apoptosis1.45745971
62MP0008469_abnormal_protein_level1.44068609
63MP0000015_abnormal_ear_pigmentation1.43661855
64MP0001845_abnormal_inflammatory_respons1.43431820
65MP0005332_abnormal_amino_acid1.43020614
66MP0002909_abnormal_adrenal_gland1.41751593
67MP0005409_darkened_coat_color1.41673311
68MP0003183_abnormal_peptide_metabolism1.41328307
69MP0002398_abnormal_bone_marrow1.39761711
70MP0000372_irregular_coat_pigmentation1.38355511
71MP0002405_respiratory_system_inflammati1.38354208
72MP0002822_catalepsy1.31855145
73MP0003195_calcinosis1.29751470
74MP0005464_abnormal_platelet_physiology1.27746066
75MP0002006_tumorigenesis1.25839694
76MP0005310_abnormal_salivary_gland1.24702578
77MP0005174_abnormal_tail_pigmentation1.24254296
78MP0002653_abnormal_ependyma_morphology1.24248380
79MP0005408_hypopigmentation1.23240637
80MP0002638_abnormal_pupillary_reflex1.22238612
81MP0005253_abnormal_eye_physiology1.21414868
82MP0003252_abnormal_bile_duct1.20628678
83MP0003011_delayed_dark_adaptation1.17861173
84MP0004782_abnormal_surfactant_physiolog1.17087637
85MP0010155_abnormal_intestine_physiology1.17045935
86MP0005084_abnormal_gallbladder_morpholo1.16763193
87MP0004147_increased_porphyrin_level1.16069399
88MP0002429_abnormal_blood_cell1.15869441
89MP0000689_abnormal_spleen_morphology1.15699808
90MP0003866_abnormal_defecation1.13490823
91MP0009745_abnormal_behavioral_response1.12891242
92MP0001944_abnormal_pancreas_morphology1.11470789
93MP0008875_abnormal_xenobiotic_pharmacok1.11204028
94MP0006292_abnormal_olfactory_placode1.10266986
95MP0009780_abnormal_chondrocyte_physiolo1.09157924
96MP0004510_myositis1.08013396
97MP0002722_abnormal_immune_system1.07846369
98MP0005085_abnormal_gallbladder_physiolo1.05201619
99MP0000230_abnormal_systemic_arterial1.03375632
100MP0004142_abnormal_muscle_tone1.02934233
101MP0001984_abnormal_olfaction1.01666295
102MP0002735_abnormal_chemical_nociception1.00434028
103MP0004130_abnormal_muscle_cell0.99408699
104MP0002272_abnormal_nervous_system0.97451810
105MP0003880_abnormal_central_pattern0.97182106
106MP0000631_abnormal_neuroendocrine_gland0.96527247
107MP0001756_abnormal_urination0.96181623
108MP0009643_abnormal_urine_homeostasis0.94515575
109MP0001765_abnormal_ion_homeostasis0.92746849
110MP0002118_abnormal_lipid_homeostasis0.91981050
111MP0002095_abnormal_skin_pigmentation0.91297037
112MP0002078_abnormal_glucose_homeostasis0.91094124
113MP0001533_abnormal_skeleton_physiology0.90819278
114MP0000343_altered_response_to0.90672316
115MP0003646_muscle_fatigue0.89256922
116MP0005386_behavior/neurological_phenoty0.88318663
117MP0004924_abnormal_behavior0.88318663
118MP0002736_abnormal_nociception_after0.87722060
119MP0005360_urolithiasis0.87647968
120MP0001664_abnormal_digestion0.87500267
121MP0005448_abnormal_energy_balance0.86685916
122MP0006036_abnormal_mitochondrial_physio0.86128084
123MP0002102_abnormal_ear_morphology0.86109744
124MP0000538_abnormal_urinary_bladder0.84760471
125MP0005584_abnormal_enzyme/coenzyme_acti0.84654051
126MP0001970_abnormal_pain_threshold0.82219661
127MP0003806_abnormal_nucleotide_metabolis0.81589492
128MP0009763_increased_sensitivity_to0.80920445
129MP0001663_abnormal_digestive_system0.80816909
130MP0008260_abnormal_autophagy0.79670010
131MP0002009_preneoplasia0.78924424
132MP0005389_reproductive_system_phenotype0.78181134
133MP0003953_abnormal_hormone_level0.76705324
134MP0005058_abnormal_lysosome_morphology0.76562152
135MP0005365_abnormal_bile_salt0.76485924
136MP0005636_abnormal_mineral_homeostasis0.75593373
137MP0002933_joint_inflammation0.75210179
138MP0000858_altered_metastatic_potential0.74686565
139MP0004947_skin_inflammation0.74162052
140MP0003283_abnormal_digestive_organ0.74160580
141MP0002064_seizures0.74114409
142MP0009765_abnormal_xenobiotic_induced0.71968131
143MP0005535_abnormal_body_temperature0.71735144
144MP0000703_abnormal_thymus_morphology0.71155896
145MP0001501_abnormal_sleep_pattern0.69488753
146MP0001968_abnormal_touch/_nociception0.69434087
147MP0004019_abnormal_vitamin_homeostasis0.66544009
148MP0001348_abnormal_lacrimal_gland0.66471846

Predicted human phenotypes

RankGene SetZ-score
1Autoimmune thrombocytopenia (HP:0001973)5.89579860
2Acute necrotizing encephalopathy (HP:0006965)4.66807672
3Mitochondrial inheritance (HP:0001427)4.25127770
4Abnormal mitochondria in muscle tissue (HP:0008316)4.11554129
5Progressive macrocephaly (HP:0004481)3.83223860
63-Methylglutaconic aciduria (HP:0003535)3.81603689
7Acute encephalopathy (HP:0006846)3.78411531
8Hepatocellular necrosis (HP:0001404)3.74650874
9Hypothermia (HP:0002045)3.58835635
10Increased CSF lactate (HP:0002490)3.58646455
11Increased hepatocellular lipid droplets (HP:0006565)3.52703743
12Increased IgM level (HP:0003496)3.48803579
13Renal Fanconi syndrome (HP:0001994)3.43589967
14Hepatic necrosis (HP:0002605)3.42878501
15Recurrent abscess formation (HP:0002722)3.32167461
16Elevated erythrocyte sedimentation rate (HP:0003565)3.29791484
17Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.28185190
18Enlarged epiphyses (HP:0010580)3.27371954
19Neonatal hypoglycemia (HP:0001998)3.25082412
20Lipid accumulation in hepatocytes (HP:0006561)3.24059339
21Hypochromic anemia (HP:0001931)3.19697724
22Insulin-resistant diabetes mellitus (HP:0000831)3.19190496
23Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.13381125
24Hyperglycemia (HP:0003074)3.08011453
25Exertional dyspnea (HP:0002875)3.07996050
26Recurrent bacterial skin infections (HP:0005406)3.03594186
27Congenital stationary night blindness (HP:0007642)2.95875495
28Cerebral edema (HP:0002181)2.95455374
29Ketoacidosis (HP:0001993)2.92847343
30Pancreatic cysts (HP:0001737)2.88227607
31Eczematoid dermatitis (HP:0000976)2.86700425
32Optic disc pallor (HP:0000543)2.86492525
33Abnormality of T cell physiology (HP:0011840)2.74697128
34Ketosis (HP:0001946)2.74528083
35Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.73027472
36Decreased activity of mitochondrial respiratory chain (HP:0008972)2.73027472
37Birth length less than 3rd percentile (HP:0003561)2.71154085
38Myositis (HP:0100614)2.70904351
39Lip pit (HP:0100267)2.70086846
40Type II lissencephaly (HP:0007260)2.65367350
41Molar tooth sign on MRI (HP:0002419)2.63351928
42Abnormality of midbrain morphology (HP:0002418)2.63351928
43Nephronophthisis (HP:0000090)2.61939373
44Retrobulbar optic neuritis (HP:0100654)2.61697402
45Optic neuritis (HP:0100653)2.61697402
46Recurrent gram-negative bacterial infections (HP:0005420)2.60560133
47Stomatitis (HP:0010280)2.59506094
48Increased intramyocellular lipid droplets (HP:0012240)2.53785001
49Increased serum lactate (HP:0002151)2.53645991
50Recurrent skin infections (HP:0001581)2.53533632
51Lactic acidosis (HP:0003128)2.52510510
52Abnormal hair whorl (HP:0010721)2.49625318
53Large for gestational age (HP:0001520)2.49082415
54Pancreatic fibrosis (HP:0100732)2.45663456
55Medial flaring of the eyebrow (HP:0010747)2.43121749
56Vacuolated lymphocytes (HP:0001922)2.36196529
57Glucose intolerance (HP:0000833)2.34722657
58IgM deficiency (HP:0002850)2.33424084
59Anterior segment dysgenesis (HP:0007700)2.32915774
60Orchitis (HP:0100796)2.31294291
61Leukodystrophy (HP:0002415)2.30984483
62Vasculitis (HP:0002633)2.30175097
63Respiratory difficulties (HP:0002880)2.29582701
64Exercise intolerance (HP:0003546)2.29302400
65Reduced antithrombin III activity (HP:0001976)2.29058406
66True hermaphroditism (HP:0010459)2.27503057
67Meningitis (HP:0001287)2.26317340
68IgG deficiency (HP:0004315)2.25898374
69Purpura (HP:0000979)2.25870573
70Abnormality of aromatic amino acid family metabolism (HP:0004338)2.25340434
71Recurrent cutaneous fungal infections (HP:0011370)2.24949872
72Chronic mucocutaneous candidiasis (HP:0002728)2.24949872
73Obstructive lung disease (HP:0006536)2.24403869
74Chronic obstructive pulmonary disease (HP:0006510)2.24403869
75Autoimmune hemolytic anemia (HP:0001890)2.24054181
76Abnormality of T cell number (HP:0011839)2.23983264
77Severe combined immunodeficiency (HP:0004430)2.23870499
78Reticulocytopenia (HP:0001896)2.22582657
79Respiratory failure (HP:0002878)2.22200788
80Parakeratosis (HP:0001036)2.22141555
81Increased muscle lipid content (HP:0009058)2.21587401
82Abnormality of renal resorption (HP:0011038)2.21440058
83Joint hemorrhage (HP:0005261)2.20206281
84Abnormality of vitamin B metabolism (HP:0004340)2.20039270
85Abnormality of cells of the erythroid lineage (HP:0012130)2.19900342
86Lethargy (HP:0001254)2.18025675
87Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.16202433
88Abnormality of eosinophils (HP:0001879)2.15127090
89Abnormality of the renal medulla (HP:0100957)2.14735115
90Petechiae (HP:0000967)2.13052495
91Abnormality of macrophages (HP:0004311)2.12810337
92Mediastinal lymphadenopathy (HP:0100721)2.12509536
93Abnormal number of erythroid precursors (HP:0012131)2.10107975
94Epileptic encephalopathy (HP:0200134)2.09669363
95Agammaglobulinemia (HP:0004432)2.09650906
96Recurrent fungal infections (HP:0002841)2.08756693
97Type I transferrin isoform profile (HP:0003642)2.07485692
98Methylmalonic aciduria (HP:0012120)2.07455750
99Encephalitis (HP:0002383)2.07414928
100Methylmalonic acidemia (HP:0002912)2.07394264
101Eosinophilia (HP:0001880)2.05818629
102T lymphocytopenia (HP:0005403)2.05602766
103Neutropenia (HP:0001875)2.04744608
104Abnormality of urine glucose concentration (HP:0011016)2.04359273
105Glycosuria (HP:0003076)2.04359273
106Abnormal rod and cone electroretinograms (HP:0008323)2.03754315
107Abnormality of secondary sexual hair (HP:0009888)2.02488898
108Abnormality of the axillary hair (HP:0100134)2.02488898
109Tubular atrophy (HP:0000092)2.01871056
110Gaze-evoked nystagmus (HP:0000640)2.01706759
111Attenuation of retinal blood vessels (HP:0007843)1.99685815
112Prolonged partial thromboplastin time (HP:0003645)1.98068688
113Abnormality of the renal cortex (HP:0011035)1.95362817
114Macrocytic anemia (HP:0001972)1.94537384
115Pallor (HP:0000980)1.93113063
116Abnormal delayed hypersensitivity skin test (HP:0002963)1.92981297
117Hyperinsulinemic hypoglycemia (HP:0000825)1.92924221
118Renal tubular dysfunction (HP:0000124)1.92501150
119Hepatosplenomegaly (HP:0001433)1.91909028
120Granulocytopenia (HP:0001913)1.91741365
121Abnormal pupillary function (HP:0007686)1.91118439
122Hyperglycinemia (HP:0002154)1.90587845
123Abolished electroretinogram (ERG) (HP:0000550)1.89924696
124Hyperphosphaturia (HP:0003109)1.89910863
125Abnormal respiratory epithelium morphology (HP:0012253)1.89696616
126Abnormal respiratory motile cilium morphology (HP:0005938)1.89696616
127Microvesicular hepatic steatosis (HP:0001414)1.89396066
128Myotonia (HP:0002486)1.88658537
129Chin dimple (HP:0010751)1.88634208
130Hyperventilation (HP:0002883)1.87978091
131Gastrointestinal stroma tumor (HP:0100723)1.87237129
132Hypergammaglobulinemia (HP:0010702)1.85872333
133Combined immunodeficiency (HP:0005387)1.85372184
134Hypoplasia of the thymus (HP:0000778)1.84917870
135Panhypogammaglobulinemia (HP:0003139)1.84745854
136Thyroiditis (HP:0100646)1.84637330
137Abnormality of T cells (HP:0002843)1.83403178
138Abnormality of glycolysis (HP:0004366)1.82591567
139Increased serum pyruvate (HP:0003542)1.82591567
140Hypoproteinemia (HP:0003075)1.80405691
141Abnormality of vitamin metabolism (HP:0100508)1.79930583
142Abnormal drinking behavior (HP:0030082)1.79396413
143Polydipsia (HP:0001959)1.79396413
144Leukocytosis (HP:0001974)1.78807979
145Aplasia/Hypoplasia of the sacrum (HP:0008517)1.78734607
146Decreased electroretinogram (ERG) amplitude (HP:0000654)1.78597263
147Systemic lupus erythematosus (HP:0002725)1.78385888
148Alveolar cell carcinoma (HP:0006519)1.77667410
149Lymphopenia (HP:0001888)1.77639444
150Nephrogenic diabetes insipidus (HP:0009806)1.73832148
151Constricted visual fields (HP:0001133)1.73723362
152Hypomagnesemia (HP:0002917)1.73590946
153Opisthotonus (HP:0002179)1.72373325
154Abnormal albumin level (HP:0012116)1.71413894
155Hypoalbuminemia (HP:0003073)1.71413894
156Retinal dysplasia (HP:0007973)1.71253740
157Hypobetalipoproteinemia (HP:0003563)1.70975225
158Hemiparesis (HP:0001269)1.70830822
159Chronic diarrhea (HP:0002028)1.70662076
160Absent/shortened dynein arms (HP:0200106)1.69547200
161Dynein arm defect of respiratory motile cilia (HP:0012255)1.69547200
162Abnormality of macular pigmentation (HP:0008002)1.68600102
163Chronic hepatic failure (HP:0100626)1.68022991

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PIK3CA4.70172976
2FRK3.65895029
3TXK3.29071912
4NME23.14341831
5MAP3K122.92148073
6IRAK42.76229860
7MAP3K142.70535094
8MAP4K22.65083171
9CASK2.52993157
10IRAK32.49406687
11STK162.48089744
12CAMKK22.43476995
13OXSR12.38368178
14IKBKE2.34860753
15PBK2.06630618
16BLK2.05079518
17TNIK2.01760206
18TLK11.96543071
19MST41.88012031
20PIM21.85941745
21TBK11.75275380
22GRK71.72939757
23TEC1.60687980
24ADRBK21.59800229
25TYK21.57292828
26IKBKB1.55713101
27MAP4K11.48914130
28ZAP701.46070693
29BMPR21.45159537
30MYLK1.44970022
31KIT1.43942479
32JAK31.41487876
33BMPR1B1.40498662
34MAP2K31.40084842
35MAP3K61.38262849
36ARAF1.37586648
37DAPK21.37324760
38NME11.37046955
39SRPK11.36286981
40NUAK11.34777888
41SYK1.32687441
42PINK11.31107574
43BTK1.28501436
44WNK41.25758378
45IRAK11.24473296
46ZAK1.20913591
47YES11.18485609
48MAP2K71.18004962
49IRAK21.17501344
50EIF2AK21.15075596
51MUSK1.14674307
52PRKCG1.14671972
53MKNK21.13657446
54WNK31.11690060
55RIPK41.11051198
56MAP2K41.10640848
57ACVR1B1.10269177
58LCK1.07470892
59CSNK1G11.05399583
60STK391.01831608
61VRK10.97253911
62MKNK10.95863192
63LYN0.95363922
64NLK0.95046803
65MAPK120.94239597
66PDK20.94152261
67FGFR40.92303108
68MAP3K110.91750263
69CAMK1D0.90242432
70CSNK1G20.90046738
71KDR0.88527436
72EIF2AK30.87690709
73RET0.87292534
74ITK0.86669621
75SIK30.85496739
76GRK50.83467390
77GRK60.82255304
78DYRK20.79087904
79BCKDK0.78325288
80TNK20.77917003
81NTRK30.74643823
82TAOK30.73549368
83MARK30.72894635
84ABL20.71650159
85PLK40.71174647
86JAK10.71029085
87NEK90.70999785
88PHKG10.70962189
89PHKG20.70962189
90INSRR0.70484290
91PIK3CG0.69916830
92STK110.69901528
93CLK10.68290337
94BCR0.67986137
95CSNK1A1L0.67646273
96PRKCQ0.67591898
97MAPKAPK50.67008783
98PAK30.64956249
99CHUK0.63960554
100EIF2AK10.63906561
101STK100.61724632
102RPS6KA50.61614792
103PIM10.58316197
104PKN10.57907060
105TIE10.57758270
106MAP2K60.57288710
107VRK20.56788691
108MAP3K130.56012521
109MAPK130.55344791
110ERBB30.55281024
111CAMKK10.55213397
112GRK10.54977097
113MINK10.54649822
114MAP3K50.53852479
115CDK190.53253508
116AKT30.52832218
117CSK0.52626373
118PRKCD0.52368466
119CSNK1G30.52225821
120CSF1R0.51588672
121BRAF0.51248752
122PRPF4B0.50230143
123FES0.50107815
124STK240.49387989
125CAMK1G0.48171090
126MAPK40.47615597
127PTK2B0.46496857
128CDK30.44910922
129CAMK2A0.44750109
130NEK60.44701755
131TSSK60.44470728
132HCK0.44369422
133MAPK150.44201865
134PRKACA0.43702291
135PRKCA0.42588324
136PRKG10.42446092
137IGF1R0.41697192
138MATK0.41608961
139BUB10.41086031
140CAMK10.39173367
141DAPK30.38894262
142PRKCI0.38594200
143TESK20.38375188
144MAP3K40.37533788
145PRKCE0.36947440
146CSNK2A10.36396862
147STK40.35391822
148ADRBK10.34746019
149CSNK1D0.34688171
150STK30.34044096
151MOS0.32967727
152PDK10.32950161
153LIMK10.32608048
154TGFBR20.31425345

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002324.22255773
2Oxidative phosphorylation_Homo sapiens_hsa001903.95282211
3Ribosome_Homo sapiens_hsa030103.47717810
4Parkinsons disease_Homo sapiens_hsa050123.30565843
5Proteasome_Homo sapiens_hsa030503.10291099
6Protein export_Homo sapiens_hsa030602.81846663
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.74705040
8Vitamin B6 metabolism_Homo sapiens_hsa007502.54487705
9Graft-versus-host disease_Homo sapiens_hsa053322.52340582
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.33743173
11Allograft rejection_Homo sapiens_hsa053302.32718801
12Primary immunodeficiency_Homo sapiens_hsa053402.31444584
13Alzheimers disease_Homo sapiens_hsa050102.27478078
14Huntingtons disease_Homo sapiens_hsa050162.10782355
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.01542305
16Intestinal immune network for IgA production_Homo sapiens_hsa046722.00189192
17Autoimmune thyroid disease_Homo sapiens_hsa053201.94088892
18RNA polymerase_Homo sapiens_hsa030201.82281381
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.79556684
20Asthma_Homo sapiens_hsa053101.75566222
21Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.61352926
22Fatty acid elongation_Homo sapiens_hsa000621.59774027
23Rheumatoid arthritis_Homo sapiens_hsa053231.55358186
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.52062395
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.48378874
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.36473821
27Phototransduction_Homo sapiens_hsa047441.32619283
28SNARE interactions in vesicular transport_Homo sapiens_hsa041301.31368058
29Staphylococcus aureus infection_Homo sapiens_hsa051501.29614946
30Fat digestion and absorption_Homo sapiens_hsa049751.29073291
31Measles_Homo sapiens_hsa051621.27469797
32Steroid biosynthesis_Homo sapiens_hsa001001.27012033
33Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.26331233
34Pyrimidine metabolism_Homo sapiens_hsa002401.25749555
35Sulfur metabolism_Homo sapiens_hsa009201.23700272
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.20019996
37Histidine metabolism_Homo sapiens_hsa003401.19873445
38Hematopoietic cell lineage_Homo sapiens_hsa046401.16802560
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.15000490
40Peroxisome_Homo sapiens_hsa041461.14939681
41Leishmaniasis_Homo sapiens_hsa051401.11941919
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.09863493
43Sulfur relay system_Homo sapiens_hsa041221.09739905
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.09598934
45Type I diabetes mellitus_Homo sapiens_hsa049401.08338010
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.08145984
47Nitrogen metabolism_Homo sapiens_hsa009101.06823728
48Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.06168626
49Primary bile acid biosynthesis_Homo sapiens_hsa001201.05779611
50Propanoate metabolism_Homo sapiens_hsa006401.03429097
51Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.02507369
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.00527379
53Collecting duct acid secretion_Homo sapiens_hsa049660.98963330
54Phenylalanine metabolism_Homo sapiens_hsa003600.98464846
55NOD-like receptor signaling pathway_Homo sapiens_hsa046210.97226721
56Antigen processing and presentation_Homo sapiens_hsa046120.96546804
57Selenocompound metabolism_Homo sapiens_hsa004500.95479288
58Other glycan degradation_Homo sapiens_hsa005110.95131415
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.94562124
60Toll-like receptor signaling pathway_Homo sapiens_hsa046200.94333076
61Tyrosine metabolism_Homo sapiens_hsa003500.91591220
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.91025089
63Folate biosynthesis_Homo sapiens_hsa007900.90763170
64Insulin secretion_Homo sapiens_hsa049110.90224738
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.87375918
66Phagosome_Homo sapiens_hsa041450.84706154
67Legionellosis_Homo sapiens_hsa051340.83360178
68Pentose and glucuronate interconversions_Homo sapiens_hsa000400.82494759
69Chemical carcinogenesis_Homo sapiens_hsa052040.81327093
70Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.80788120
71Retinol metabolism_Homo sapiens_hsa008300.80569266
72Pertussis_Homo sapiens_hsa051330.79373401
73Malaria_Homo sapiens_hsa051440.78785058
74Arachidonic acid metabolism_Homo sapiens_hsa005900.76163817
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75953525
76Fatty acid degradation_Homo sapiens_hsa000710.75804092
77Sphingolipid metabolism_Homo sapiens_hsa006000.74758257
78Cardiac muscle contraction_Homo sapiens_hsa042600.74404773
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.71692736
80Regulation of autophagy_Homo sapiens_hsa041400.71318066
81Herpes simplex infection_Homo sapiens_hsa051680.69712134
82ABC transporters_Homo sapiens_hsa020100.69174605
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68778726
84* Metabolic pathways_Homo sapiens_hsa011000.65903994
85Ether lipid metabolism_Homo sapiens_hsa005650.64502588
86Complement and coagulation cascades_Homo sapiens_hsa046100.63720988
87Tryptophan metabolism_Homo sapiens_hsa003800.63489885
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62138837
89Mineral absorption_Homo sapiens_hsa049780.61692849
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60740343
91Basal transcription factors_Homo sapiens_hsa030220.60331585
92T cell receptor signaling pathway_Homo sapiens_hsa046600.60138701
93Vitamin digestion and absorption_Homo sapiens_hsa049770.59503355
94beta-Alanine metabolism_Homo sapiens_hsa004100.55842395
95Influenza A_Homo sapiens_hsa051640.55071639
96Glutathione metabolism_Homo sapiens_hsa004800.53411149
97Nicotine addiction_Homo sapiens_hsa050330.53186904
98Jak-STAT signaling pathway_Homo sapiens_hsa046300.52663800
99Purine metabolism_Homo sapiens_hsa002300.52497471
100Nucleotide excision repair_Homo sapiens_hsa034200.51590592
101Maturity onset diabetes of the young_Homo sapiens_hsa049500.50904302
102African trypanosomiasis_Homo sapiens_hsa051430.50010195
103Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49304543
104Tuberculosis_Homo sapiens_hsa051520.48855586
105Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48691558
106Homologous recombination_Homo sapiens_hsa034400.48674608
107Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.48168289
108Vibrio cholerae infection_Homo sapiens_hsa051100.45823984
109Renin secretion_Homo sapiens_hsa049240.45051424
110Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44852507
111Osteoclast differentiation_Homo sapiens_hsa043800.43689793
112Renin-angiotensin system_Homo sapiens_hsa046140.43435202
113Arginine biosynthesis_Homo sapiens_hsa002200.42803350
114Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41190699
115Salivary secretion_Homo sapiens_hsa049700.40991866
116Linoleic acid metabolism_Homo sapiens_hsa005910.39854591
117Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39283537
118Serotonergic synapse_Homo sapiens_hsa047260.38969375
119Salmonella infection_Homo sapiens_hsa051320.38540865
120Mismatch repair_Homo sapiens_hsa034300.38090204
121Fanconi anemia pathway_Homo sapiens_hsa034600.37530748
122Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.37333013
123Epstein-Barr virus infection_Homo sapiens_hsa051690.36601767
124Chemokine signaling pathway_Homo sapiens_hsa040620.36327929
125Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35499082
126Fatty acid metabolism_Homo sapiens_hsa012120.35359913
127PPAR signaling pathway_Homo sapiens_hsa033200.34883808
128Hepatitis C_Homo sapiens_hsa051600.34111770
129Olfactory transduction_Homo sapiens_hsa047400.33974404
130Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.33228044
131Butanoate metabolism_Homo sapiens_hsa006500.30324368
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.29870969
133Starch and sucrose metabolism_Homo sapiens_hsa005000.29712929

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