IDO1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1seminiferous tubule development (GO:0072520)9.86726830
2regulation of T-helper 1 cell differentiation (GO:0045625)8.60283186
3regulation of dendritic cell antigen processing and presentation (GO:0002604)7.18178956
4positive regulation of T-helper cell differentiation (GO:0045624)6.04774971
5positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)5.76721115
6positive regulation of cAMP-mediated signaling (GO:0043950)5.54615894
7positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)5.48115604
8T-helper 1 type immune response (GO:0042088)5.44963693
9positive regulation of antigen processing and presentation (GO:0002579)5.38650470
10regulation of T-helper cell differentiation (GO:0045622)5.13946402
11positive regulation of T-helper 1 type immune response (GO:0002827)5.06884353
12positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)4.99434202
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.93268391
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.93268391
15regulation of antigen processing and presentation (GO:0002577)4.92037616
16regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)4.88073357
17regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)4.86969247
18sperm capacitation (GO:0048240)4.86690384
19negative regulation of interleukin-12 production (GO:0032695)4.84696928
20bundle of His cell to Purkinje myocyte communication (GO:0086069)4.81940689
21type I interferon signaling pathway (GO:0060337)4.78332492
22cellular response to type I interferon (GO:0071357)4.78332492
23response to type I interferon (GO:0034340)4.70926120
24maintenance of gastrointestinal epithelium (GO:0030277)4.69598951
25antigen processing and presentation of endogenous antigen (GO:0019883)4.61073168
26interferon-gamma-mediated signaling pathway (GO:0060333)4.58413216
27regulation of T-helper 1 type immune response (GO:0002825)4.47995350
28regulation of vitamin D biosynthetic process (GO:0060556)4.47461797
29interferon-gamma secretion (GO:0072643)4.42253713
30positive regulation of Cdc42 GTPase activity (GO:0043089)4.38332196
31pyrimidine-containing compound transmembrane transport (GO:0072531)4.35565776
32* positive regulation of interleukin-12 production (GO:0032735)4.34918315
33angiotensin maturation (GO:0002003)4.25471056
34O-glycan processing (GO:0016266)4.24726342
35* regulation of interleukin-12 production (GO:0032655)4.24314013
36regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)4.21739341
37* positive regulation of type 2 immune response (GO:0002830)4.17625574
38dendritic cell chemotaxis (GO:0002407)4.15424746
39regulation of interferon-alpha production (GO:0032647)4.12960631
40vitamin transmembrane transport (GO:0035461)4.05252247
41response to peptidoglycan (GO:0032494)4.00160311
42regulation of interleukin-1 beta secretion (GO:0050706)3.97355404
43dendritic cell differentiation (GO:0097028)3.95093185
44positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.92394133
45positive regulation of interleukin-10 production (GO:0032733)3.91903587
46defense response to protozoan (GO:0042832)3.89244026
47regulation of interferon-gamma biosynthetic process (GO:0045072)3.86985286
48lymphocyte chemotaxis (GO:0048247)3.82472625
49cellular response to interferon-gamma (GO:0071346)3.80703601
50response to interferon-gamma (GO:0034341)3.79220853
51pyrimidine ribonucleoside catabolic process (GO:0046133)3.77953740
52T cell migration (GO:0072678)3.77738201
53lipopolysaccharide-mediated signaling pathway (GO:0031663)3.77612638
54positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.76215284
55negative regulation of protein autophosphorylation (GO:0031953)3.75640977
56NIK/NF-kappaB signaling (GO:0038061)3.75537919
57positive regulation of NF-kappaB import into nucleus (GO:0042346)3.75044197
58positive regulation of interferon-alpha production (GO:0032727)3.74593902
59intestinal absorption (GO:0050892)3.74374823
60UDP-N-acetylglucosamine metabolic process (GO:0006047)3.72929806
61glial cell proliferation (GO:0014009)3.72375635
62positive regulation of defense response to virus by host (GO:0002230)3.71945875
63immunoglobulin mediated immune response (GO:0016064)3.69928477
64cGMP-mediated signaling (GO:0019934)3.69619958
65positive regulation of interleukin-1 beta secretion (GO:0050718)3.69564446
66regulation of vitamin metabolic process (GO:0030656)3.65117106
67regulation of guanylate cyclase activity (GO:0031282)3.64699199
68thyroid hormone metabolic process (GO:0042403)3.63699956
69positive regulation of gamma-delta T cell activation (GO:0046645)3.62640208
70epithelial structure maintenance (GO:0010669)3.62428528
71regulation of mononuclear cell migration (GO:0071675)3.61829089
72positive regulation of interleukin-17 production (GO:0032740)3.59641067
73hepatocyte apoptotic process (GO:0097284)3.57674421
74negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.57583304
75regulation of interleukin-1 secretion (GO:0050704)3.57095654
76macrophage activation involved in immune response (GO:0002281)3.56844648
77intestinal epithelial cell development (GO:0060576)3.56228818
78positive regulation of alpha-beta T cell proliferation (GO:0046641)3.55992271
79response to protozoan (GO:0001562)3.53647475
80sulfur amino acid catabolic process (GO:0000098)3.53587321
81myeloid dendritic cell differentiation (GO:0043011)3.51160596
82positive regulation of alpha-beta T cell differentiation (GO:0046638)3.51134715
83phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.49230815
84positive regulation of interleukin-1 secretion (GO:0050716)3.47581437
85negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.46444742
86calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.44749469
87regulation of alpha-beta T cell proliferation (GO:0046640)3.44252771
88regulation of inflammatory response to antigenic stimulus (GO:0002861)3.40486315
89positive regulation of neutrophil chemotaxis (GO:0090023)3.39436998
90positive regulation of neutrophil migration (GO:1902624)3.39436998
91regulation of cytokine secretion involved in immune response (GO:0002739)3.39123735
92negative regulation of viral genome replication (GO:0045071)3.38294896
93cytidine metabolic process (GO:0046087)3.35914224
94cytidine catabolic process (GO:0006216)3.35914224
95cytidine deamination (GO:0009972)3.35914224
96regulation of interferon-beta biosynthetic process (GO:0045357)3.35789755
97positive regulation of toll-like receptor signaling pathway (GO:0034123)3.34154581
98regulation of podosome assembly (GO:0071801)3.33402065
99response to nitric oxide (GO:0071731)3.32153234
100modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.29494721
101positive regulation by organism of defense response of other organism involved in symbiotic interact3.29494721
102modulation by symbiont of host immune response (GO:0052553)3.29494721
103positive regulation by symbiont of host defense response (GO:0052509)3.29494721
104modulation by symbiont of host defense response (GO:0052031)3.29494721
105modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.29494721
106modulation of growth of symbiont involved in interaction with host (GO:0044144)3.29355703
107regulation of growth of symbiont in host (GO:0044126)3.29355703
108negative regulation of growth of symbiont in host (GO:0044130)3.29355703
109negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.29355703
110regulation of alpha-beta T cell differentiation (GO:0046637)3.28897869
111negative regulation of interleukin-17 production (GO:0032700)3.25330997
112regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.23123629
113digestion (GO:0007586)3.22270922
114positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.21679627
115positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.21671071
116intestinal cholesterol absorption (GO:0030299)3.17530591
117* regulation of interleukin-10 production (GO:0032653)3.17294633
118defense response to virus (GO:0051607)3.15785667
119negative regulation of cell killing (GO:0031342)3.15646146
120negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.15646146
121adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.14137196
122positive regulation of interferon-beta production (GO:0032728)3.12518217
123L-serine transport (GO:0015825)3.10019335
124detection of molecule of bacterial origin (GO:0032490)3.09962882
125dendritic cell migration (GO:0036336)3.09319137
126cellular response to interferon-alpha (GO:0035457)3.08506999
127cytokine secretion (GO:0050663)3.08504401
128regulation of interleukin-12 biosynthetic process (GO:0045075)3.07932198
129regulation of type I interferon-mediated signaling pathway (GO:0060338)3.05844081
130cellular response to lipopolysaccharide (GO:0071222)3.04913372
131actin filament depolymerization (GO:0030042)3.03121330
132negative regulation of interleukin-8 production (GO:0032717)3.01480550
133hemidesmosome assembly (GO:0031581)2.99650780
134positive regulation of guanylate cyclase activity (GO:0031284)2.98200026
135serine transport (GO:0032329)2.86528635
136hypotonic response (GO:0006971)2.85254759
137single fertilization (GO:0007338)2.84449902
138regulation of RIG-I signaling pathway (GO:0039535)2.84411589
139response to histamine (GO:0034776)2.81810313
140regulation of viral release from host cell (GO:1902186)2.76590863
141hydrogen peroxide catabolic process (GO:0042744)2.75751533
142cell communication involved in cardiac conduction (GO:0086065)2.73685571
143digestive system process (GO:0022600)2.72624623
144regulation of heart rate by cardiac conduction (GO:0086091)2.71783158
145transepithelial transport (GO:0070633)2.71389340
146cellular ketone body metabolic process (GO:0046950)2.68472113
147synaptic transmission, dopaminergic (GO:0001963)2.68460302
148bile acid and bile salt transport (GO:0015721)2.66114144
149transcytosis (GO:0045056)2.65725688
150heterotypic cell-cell adhesion (GO:0034113)2.64956374
151antigen processing and presentation via MHC class Ib (GO:0002475)2.64723485
152protein O-linked glycosylation (GO:0006493)2.63383193
153neurotransmitter biosynthetic process (GO:0042136)2.60251033
154positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.59192473
155cardiac conduction (GO:0061337)2.59144222
156L-fucose catabolic process (GO:0042355)2.58869947
157fucose catabolic process (GO:0019317)2.58869947
158L-fucose metabolic process (GO:0042354)2.58869947
1593-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.55817066
160purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.55817066
161reverse cholesterol transport (GO:0043691)2.53290672
162lipoprotein transport (GO:0042953)2.52941340
163thrombin receptor signaling pathway (GO:0070493)2.51829214
164phosphatidylcholine biosynthetic process (GO:0006656)2.50549661
165flavonoid metabolic process (GO:0009812)2.50162213
166positive regulation of pseudopodium assembly (GO:0031274)2.49828191
167lipopolysaccharide biosynthetic process (GO:0009103)2.47681240
168regulation of chemokine secretion (GO:0090196)2.46822151
169hydrogen peroxide metabolic process (GO:0042743)2.46260925
170adenosine receptor signaling pathway (GO:0001973)2.46048800
171regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.45912905
172positive regulation of glycoprotein metabolic process (GO:1903020)2.45815654
173negative regulation of sodium ion transport (GO:0010766)2.45770425
174peptidyl-tyrosine autophosphorylation (GO:0038083)2.45737995
175ventricular cardiac muscle cell action potential (GO:0086005)2.44710195
176positive regulation of cellular amide metabolic process (GO:0034250)2.42848946
177thyroid hormone generation (GO:0006590)2.41688853
178N-acetylneuraminate metabolic process (GO:0006054)2.40040627
179prepulse inhibition (GO:0060134)2.38703457
180sialylation (GO:0097503)2.36843956
181regulation of actin nucleation (GO:0051125)2.36275063
182regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.36126121
183negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.34370097
184positive regulation of actin filament depolymerization (GO:0030836)2.31641205
185response to hydroperoxide (GO:0033194)2.31497187
186antimicrobial humoral response (GO:0019730)2.30920937
187antibacterial humoral response (GO:0019731)2.29001981
188regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.28519367
189response to bacterium (GO:0009617)2.27696854
190negative regulation of protein tyrosine kinase activity (GO:0061099)2.27045762
191protein autoprocessing (GO:0016540)2.26805489
192positive regulation of glycoprotein biosynthetic process (GO:0010560)2.25602628
193potassium ion homeostasis (GO:0055075)2.25364409
194substrate-independent telencephalic tangential migration (GO:0021826)2.24143289
195substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.24143289
196negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.23902006

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse5.83706159
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.81830752
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.85125740
4TP63_17297297_ChIP-ChIP_HaCaT_Human4.77045373
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.99334212
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.33142283
7STAT4_19710469_ChIP-ChIP_TH1__Mouse3.24293144
8NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.03457688
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.01066978
10CDX2_20551321_ChIP-Seq_CACO-2_Human2.91712101
11IKZF1_21737484_ChIP-ChIP_HCT116_Human2.89177814
12CDX2_19796622_ChIP-Seq_MESCs_Mouse2.85865327
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.72418191
14NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.61243197
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.60711028
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.44262905
17TRIM28_21343339_ChIP-Seq_HEK293_Human2.37225509
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.28421274
19SOX2_20726797_ChIP-Seq_SW620_Human2.27847632
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.19224407
21ESR1_21235772_ChIP-Seq_MCF-7_Human2.17623901
22SOX2_27498859_Chip-Seq_STOMACH_Mouse2.14955162
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.14660895
24ESR2_21235772_ChIP-Seq_MCF-7_Human2.13495935
25TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.12927976
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.07827802
27GATA1_22025678_ChIP-Seq_K562_Human2.01116081
28SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.00964533
29ESR1_20079471_ChIP-ChIP_T-47D_Human1.98440383
30FOXO3_23340844_ChIP-Seq_DLD1_Human1.82586431
31GATA4_25053715_ChIP-Seq_YYC3_Human1.77357017
32STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.76315996
33PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.68386597
34PPARA_22158963_ChIP-Seq_LIVER_Mouse1.66119490
35ZNF217_24962896_ChIP-Seq_MCF-7_Human1.65361342
36NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.65110875
37KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.60992795
38KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.60992795
39KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.60992795
40SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.58761518
41* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.58373607
42RXR_22158963_ChIP-Seq_LIVER_Mouse1.56560735
43GATA6_25053715_ChIP-Seq_YYC3_Human1.54098423
44LXR_22158963_ChIP-Seq_LIVER_Mouse1.54074632
45SPI1_23547873_ChIP-Seq_NB4_Human1.53958899
46TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.52346386
47MYB_26560356_Chip-Seq_TH2_Human1.51539802
48RUNX_20019798_ChIP-Seq_JUKART_Human1.50884841
49CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.47951005
50BRD4_27068464_Chip-Seq_AML-cells_Mouse1.45476926
51PPAR_26484153_Chip-Seq_NCI-H1993_Human1.44359857
52SPI1_23127762_ChIP-Seq_K562_Human1.44079943
53KLF5_25053715_ChIP-Seq_YYC3_Human1.40744977
54CLOCK_20551151_ChIP-Seq_293T_Human1.40653065
55ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.39333488
56DROSHA_22980978_ChIP-Seq_HELA_Human1.38992479
57AR_21572438_ChIP-Seq_LNCaP_Human1.35932439
58SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.35268865
59BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.34189139
60SCL_19346495_ChIP-Seq_HPC-7_Human1.33934587
61RUNX1_27514584_Chip-Seq_MCF-7_Human1.33325703
62FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.33075059
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31167401
64VDR_24763502_ChIP-Seq_THP-1_Human1.29863311
65MAF_26560356_Chip-Seq_TH1_Human1.29617698
66RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.28506252
67CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.26648605
68PU_27001747_Chip-Seq_BMDM_Mouse1.25034051
69EGR1_19032775_ChIP-ChIP_M12_Human1.24263255
70PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22831355
71MYB_26560356_Chip-Seq_TH1_Human1.20765338
72HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.19290804
73ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19277878
74CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17161662
75SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.15630289
76CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14955808
77TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13936351
78FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.13893107
79ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13867852
80DNAJC2_21179169_ChIP-ChIP_NT2_Human1.13388219
81SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.13048805
82SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.09736864
83RUNX1_22412390_ChIP-Seq_EML_Mouse1.09712975
84RACK7_27058665_Chip-Seq_MCF-7_Human1.09574886
85SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09358246
86SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.08905941
87NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.08686109
88MTF2_20144788_ChIP-Seq_MESCs_Mouse1.08485125
89GATA2_19941826_ChIP-Seq_K562_Human1.07632269
90STAT1_20625510_ChIP-Seq_HELA_Human1.06740257
91KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05434977
92CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.05317733
93STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.05024386
94EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04064327
95GATA3_26560356_Chip-Seq_TH2_Human1.03911606
96STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.03771203
97RXR_22108803_ChIP-Seq_LS180_Human1.03589270
98AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.03181825
99E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.03124731
100ERG_21242973_ChIP-ChIP_JURKAT_Human1.02281193
101FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.01824680
102NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01111794
103ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00682784
104VDR_24787735_ChIP-Seq_THP-1_Human1.00309077
105RARB_27405468_Chip-Seq_BRAIN_Mouse0.99666015
106LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.97656155
107CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97506342
108GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.97503411
109GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97016196
110VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96406076
111GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.95912068
112* SMAD3_21741376_ChIP-Seq_HESCs_Human0.94746454
113ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94613607
114CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94547389
115EZH2_18974828_ChIP-Seq_MESCs_Mouse0.94353139
116RNF2_18974828_ChIP-Seq_MESCs_Mouse0.94353139
117GATA3_27048872_Chip-Seq_THYMUS_Human0.93202400
118GATA2_21666600_ChIP-Seq_HMVEC_Human0.92078744
119LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.92045331
120Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.91940129
121BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.91910972
122PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91336529
123SMAD4_21741376_ChIP-Seq_HESCs_Human0.90043649
124PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89783225
125CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.89728754
126NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.89437290
127SMAD_19615063_ChIP-ChIP_OVARY_Human0.89280568
128GATA3_24758297_ChIP-Seq_MCF-7_Human0.88866493
129HIF1A_21447827_ChIP-Seq_MCF-7_Human0.87732531
130MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.86966675
131VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.86121279
132SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86014710
133GATA1_19941826_ChIP-Seq_K562_Human0.85882917
134FOXM1_26456572_ChIP-Seq_MCF-7_Human0.85310891
135JARID2_20075857_ChIP-Seq_MESCs_Mouse0.85093333
136ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.85064854
137FOXA1_25552417_ChIP-Seq_VCAP_Human0.84312935
138KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.84230913
139AHR_22903824_ChIP-Seq_MCF-7_Human0.84128446
140GATA1_19941827_ChIP-Seq_MEL_Mouse0.83243524
141MYC_19915707_ChIP-ChIP_AK7_Human0.82929020
142ATF3_27146783_Chip-Seq_COLON_Human0.82598567
143SOX9_24532713_ChIP-Seq_HFSC_Mouse0.81653451
144SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.81600496
145SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.81600496
146PIAS1_25552417_ChIP-Seq_VCAP_Human0.81307040
147JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81077322
148STAT1_17558387_ChIP-Seq_HELA_Human0.80785228
149IRF8_27001747_Chip-Seq_BMDM_Mouse0.80706502
150TFEB_21752829_ChIP-Seq_HELA_Human0.80205834
151JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.80129439
152BCAT_22108803_ChIP-Seq_LS180_Human0.79617338
153PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.79219037
154FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.78532142
155ESR1_15608294_ChIP-ChIP_MCF-7_Human0.78153989
156IRF8_22096565_ChIP-ChIP_GC-B_Human0.77315887
157FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.77056574
158TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.76776103
159GATA2_22383799_ChIP-Seq_G1ME_Mouse0.75121893
160VDR_21846776_ChIP-Seq_THP-1_Human0.70694494
161KDM2B_26808549_Chip-Seq_SUP-B15_Human0.70649182
162UTX_26944678_Chip-Seq_JUKART_Human0.69766915
163GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.69510361
164SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.69042182
165SALL4_18804426_ChIP-ChIP_XEN_Mouse0.68277340
166TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.66141848
167ELK3_25401928_ChIP-Seq_HUVEC_Human0.64949857
168MAF_26560356_Chip-Seq_TH2_Human0.62968456
169STAT3_1855785_ChIP-Seq_MESCs_Mouse0.61478404
170KDM2B_26808549_Chip-Seq_DND41_Human0.60887183
171ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.59415079
172NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.58532466
173CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.57056246

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy5.62210790
2MP0010234_abnormal_vibrissa_follicle5.29531357
3MP0002254_reproductive_system_inflammat4.27509583
4MP0004264_abnormal_extraembryonic_tissu3.82980795
5MP0006082_CNS_inflammation3.81168097
6MP0000685_abnormal_immune_system3.48075733
7MP0005360_urolithiasis3.28988482
8MP0005387_immune_system_phenotype3.15016143
9MP0001790_abnormal_immune_system3.15016143
10MP0005671_abnormal_response_to3.13155051
11MP0005000_abnormal_immune_tolerance2.98620613
12MP0001666_abnormal_nutrient_absorption2.95076856
13MP0004510_myositis2.87765440
14MP0005451_abnormal_body_composition2.79246438
15MP0003866_abnormal_defecation2.78156140
16MP0003436_decreased_susceptibility_to2.76676409
17MP0001800_abnormal_humoral_immune2.73173393
18MP0005085_abnormal_gallbladder_physiolo2.64803133
19MP0003300_gastrointestinal_ulcer2.54513548
20* MP0002452_abnormal_antigen_presenting2.49147679
21* MP0002723_abnormal_immune_serum2.42495457
22MP0002419_abnormal_innate_immunity2.40559541
23MP0002876_abnormal_thyroid_physiology2.18019101
24MP0001873_stomach_inflammation2.13247087
25MP0010155_abnormal_intestine_physiology2.07930455
26MP0002139_abnormal_hepatobiliary_system2.04769359
27MP0003303_peritoneal_inflammation2.00891592
28MP0004043_abnormal_pH_regulation1.95629983
29* MP0001819_abnormal_immune_cell1.94635308
30MP0002420_abnormal_adaptive_immunity1.90369574
31MP0001881_abnormal_mammary_gland1.84895249
32MP0003878_abnormal_ear_physiology1.81465615
33MP0005377_hearing/vestibular/ear_phenot1.81465615
34MP0003075_altered_response_to1.79629481
35MP0008469_abnormal_protein_level1.79269354
36MP0001663_abnormal_digestive_system1.78137167
37MP0005166_decreased_susceptibility_to1.76580894
38MP0002909_abnormal_adrenal_gland1.74578998
39MP0003448_altered_tumor_morphology1.71128765
40MP0010329_abnormal_lipoprotein_level1.68064072
41MP0000343_altered_response_to1.67374844
42MP0005058_abnormal_lysosome_morphology1.66346517
43MP0002405_respiratory_system_inflammati1.64644380
44MP0000537_abnormal_urethra_morphology1.60716755
45MP0005248_abnormal_Harderian_gland1.60513391
46MP0000462_abnormal_digestive_system1.55871733
47MP0001501_abnormal_sleep_pattern1.53391433
48MP0005310_abnormal_salivary_gland1.50131532
49MP0003195_calcinosis1.48899487
50MP0005167_abnormal_blood-brain_barrier1.48852334
51MP0003252_abnormal_bile_duct1.48130780
52MP0003191_abnormal_cellular_cholesterol1.48120641
53MP0004947_skin_inflammation1.47454789
54MP0005381_digestive/alimentary_phenotyp1.45615517
55MP0002138_abnormal_hepatobiliary_system1.43295664
56MP0000716_abnormal_immune_system1.42984742
57MP0009333_abnormal_splenocyte_physiolog1.41438093
58MP0009785_altered_susceptibility_to1.41381659
59MP0001765_abnormal_ion_homeostasis1.40562229
60MP0008872_abnormal_physiological_respon1.40431025
61MP0010678_abnormal_skin_adnexa1.39737097
62MP0008875_abnormal_xenobiotic_pharmacok1.36076737
63MP0003172_abnormal_lysosome_physiology1.33775557
64MP0008004_abnormal_stomach_pH1.32995786
65MP0002332_abnormal_exercise_endurance1.31961476
66MP0002796_impaired_skin_barrier1.31829092
67MP0001346_abnormal_lacrimal_gland1.30975495
68MP0000477_abnormal_intestine_morphology1.30948884
69MP0004270_analgesia1.26431335
70MP0003329_amyloid_beta_deposits1.23041280
71MP0000604_amyloidosis1.22957896
72MP0009278_abnormal_bone_marrow1.21240433
73MP0001664_abnormal_digestion1.20644967
74MP0001348_abnormal_lacrimal_gland1.20223644
75MP0000490_abnormal_crypts_of1.19588598
76MP0005397_hematopoietic_system_phenotyp1.19250834
77MP0001545_abnormal_hematopoietic_system1.19250834
78MP0000013_abnormal_adipose_tissue1.18897277
79MP0004858_abnormal_nervous_system1.18730299
80MP0004883_abnormal_blood_vessel1.18072089
81MP0002398_abnormal_bone_marrow1.17828077
82MP0002998_abnormal_bone_remodeling1.17466201
83MP0005365_abnormal_bile_salt1.16708383
84MP0009763_increased_sensitivity_to1.14979673
85MP0003183_abnormal_peptide_metabolism1.14726010
86MP0002163_abnormal_gland_morphology1.14687722
87MP0009765_abnormal_xenobiotic_induced1.14353893
88MP0005164_abnormal_response_to1.13890268
89MP0002006_tumorigenesis1.11588342
90MP0003045_fibrosis1.11364623
91MP0003724_increased_susceptibility_to1.10344569
92MP0000858_altered_metastatic_potential1.08840754
93MP0006054_spinal_hemorrhage1.08221460
94MP0005623_abnormal_meninges_morphology1.07608447
95MP0002429_abnormal_blood_cell1.07176742
96MP0001440_abnormal_grooming_behavior1.06226656
97MP0002166_altered_tumor_susceptibility1.03997785
98MP0005584_abnormal_enzyme/coenzyme_acti1.03070680
99MP0001529_abnormal_vocalization1.02749791
100MP0003646_muscle_fatigue1.01077640
101MP0009643_abnormal_urine_homeostasis0.99626750
102MP0000003_abnormal_adipose_tissue0.98752626
103MP0003941_abnormal_skin_development0.98273535
104MP0003806_abnormal_nucleotide_metabolis0.98000946
105MP0005636_abnormal_mineral_homeostasis0.97434115
106MP0009840_abnormal_foam_cell0.96940702
107MP0003566_abnormal_cell_adhesion0.96185658
108MP0001533_abnormal_skeleton_physiology0.95233032
109MP0004859_abnormal_synaptic_plasticity0.94190367
110MP0004185_abnormal_adipocyte_glucose0.93858443
111MP0001853_heart_inflammation0.91616508
112MP0008260_abnormal_autophagy0.90129179
113MP0002722_abnormal_immune_system0.89561667
114MP0004019_abnormal_vitamin_homeostasis0.89091011
115MP0010352_gastrointestinal_tract_polyps0.89000547
116MP0001849_ear_inflammation0.87043601
117MP0002277_abnormal_respiratory_mucosa0.86797718
118MP0005165_increased_susceptibility_to0.85855369
119MP0000689_abnormal_spleen_morphology0.85636299
120MP0003091_abnormal_cell_migration0.85555526
121MP0005464_abnormal_platelet_physiology0.84014325
122MP0000627_abnormal_mammary_gland0.83843851
123MP0005025_abnormal_response_to0.83212501
124MP0002118_abnormal_lipid_homeostasis0.82260832
125MP0002733_abnormal_thermal_nociception0.81827634
126MP0002098_abnormal_vibrissa_morphology0.80803973
127MP0004782_abnormal_surfactant_physiolog0.80088950
128MP0002148_abnormal_hypersensitivity_rea0.77550567
129MP0009764_decreased_sensitivity_to0.77157364
130MP0000538_abnormal_urinary_bladder0.76894827
131MP0001845_abnormal_inflammatory_respons0.76726938
132MP0003763_abnormal_thymus_physiology0.75948145
133MP0002896_abnormal_bone_mineralization0.75306449
134MP0001835_abnormal_antigen_presentation0.75066209
135MP0003453_abnormal_keratinocyte_physiol0.74467558
136MP0005390_skeleton_phenotype0.73068566
137MP0003879_abnormal_hair_cell0.72623853
138MP0005319_abnormal_enzyme/_coenzyme0.72084486
139MP0008873_increased_physiological_sensi0.71030286
140MP0003705_abnormal_hypodermis_morpholog0.70526465
141MP0009745_abnormal_behavioral_response0.69824516
142MP0004130_abnormal_muscle_cell0.69692139
143MP0002136_abnormal_kidney_physiology0.69349383
144MP0003656_abnormal_erythrocyte_physiolo0.68691225
145MP0005332_abnormal_amino_acid0.67771005
146MP0000427_abnormal_hair_cycle0.67265215
147MP0005379_endocrine/exocrine_gland_phen0.66353062
148MP0002693_abnormal_pancreas_physiology0.65253630
149MP0003690_abnormal_glial_cell0.64577751
150MP0000609_abnormal_liver_physiology0.64130625
151MP0008874_decreased_physiological_sensi0.62778660
152MP0004808_abnormal_hematopoietic_stem0.59420720
153MP0002877_abnormal_melanocyte_morpholog0.59398521
154MP0000920_abnormal_myelination0.57305291
155MP0010307_abnormal_tumor_latency0.56766607
156MP0003795_abnormal_bone_structure0.51706701
157MP0005647_abnormal_sex_gland0.51041381
158MP0003221_abnormal_cardiomyocyte_apopto0.50011016
159MP0000249_abnormal_blood_vessel0.49188241
160MP0000371_diluted_coat_color0.47717333

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)6.66891671
2Optic neuritis (HP:0100653)6.35972848
3Retrobulbar optic neuritis (HP:0100654)6.35972848
4Orchitis (HP:0100796)6.05721105
5Pustule (HP:0200039)5.77969498
6Gastrointestinal infarctions (HP:0005244)5.77513428
7Myositis (HP:0100614)5.15624369
8Malnutrition (HP:0004395)5.09601383
9Recurrent bacterial skin infections (HP:0005406)4.96825950
10Oligomenorrhea (HP:0000876)4.94041701
11Prostate neoplasm (HP:0100787)4.80362302
12Abnormality of macrophages (HP:0004311)4.57335038
13Keratoconjunctivitis sicca (HP:0001097)4.42441747
14Hemoptysis (HP:0002105)4.37461805
15Abnormality of glycolipid metabolism (HP:0010969)4.32379075
16Abnormality of liposaccharide metabolism (HP:0010968)4.32379075
17Abnormality of glycosphingolipid metabolism (HP:0004343)4.32379075
18Increased IgM level (HP:0003496)4.32267942
19Recurrent abscess formation (HP:0002722)4.27464525
20Abnormality of small intestinal villus morphology (HP:0011472)4.18614184
21Villous atrophy (HP:0011473)4.18614184
22Systemic lupus erythematosus (HP:0002725)4.11195001
23Keratoconjunctivitis (HP:0001096)4.05821477
24Vasculitis (HP:0002633)3.97574904
25Gangrene (HP:0100758)3.94052354
26Mediastinal lymphadenopathy (HP:0100721)3.87396776
27Hematochezia (HP:0002573)3.79209940
28Onycholysis (HP:0001806)3.67728024
29Pulmonary infiltrates (HP:0002113)3.60332890
30Stomatitis (HP:0010280)3.56038584
31Milia (HP:0001056)3.45306893
32Ileus (HP:0002595)3.43095413
33Polygenic inheritance (HP:0010982)3.37300310
34Palpitations (HP:0001962)3.36147107
35Amaurosis fugax (HP:0100576)3.31414035
36Recurrent viral infections (HP:0004429)3.31099137
37Anorexia (HP:0002039)3.25990944
38Goiter (HP:0000853)3.20523085
39Loss of speech (HP:0002371)3.19541450
40Arterial thrombosis (HP:0004420)3.14946905
41Recurrent fungal infections (HP:0002841)3.13797052
42Micronodular cirrhosis (HP:0001413)3.12940583
43Chronic otitis media (HP:0000389)3.12452237
44Recurrent skin infections (HP:0001581)3.07873594
45Hypergammaglobulinemia (HP:0010702)3.06397628
46Abnormality of glutamine family amino acid metabolism (HP:0010902)2.99907518
47Cheilitis (HP:0100825)2.99896776
48Chronic diarrhea (HP:0002028)2.97051997
49Abnormality of T cell number (HP:0011839)2.94917326
50Chest pain (HP:0100749)2.92112302
51Amyloidosis (HP:0011034)2.91874808
52T lymphocytopenia (HP:0005403)2.90765726
53Premature loss of primary teeth (HP:0006323)2.90092665
54Abdominal distention (HP:0003270)2.88752033
55Flat acetabular roof (HP:0003180)2.85380577
56Alopecia of scalp (HP:0002293)2.85211216
57Elevated erythrocyte sedimentation rate (HP:0003565)2.78897659
58Recurrent gram-negative bacterial infections (HP:0005420)2.78166549
59Disinhibition (HP:0000734)2.77191042
60Encephalitis (HP:0002383)2.76283588
61Abnormality of proline metabolism (HP:0010907)2.75530104
62Hydroxyprolinuria (HP:0003080)2.75530104
63Hyperactive renin-angiotensin system (HP:0000841)2.74377803
64Hypertensive crisis (HP:0100735)2.74127004
65Vascular calcification (HP:0004934)2.72897193
66Autoimmune thrombocytopenia (HP:0001973)2.70856422
67Myokymia (HP:0002411)2.68334040
68Pili torti (HP:0003777)2.65945578
69Abnormality of the pleura (HP:0002103)2.64822186
70Leukocytosis (HP:0001974)2.64652096
71Meningitis (HP:0001287)2.62437348
72Vacuolated lymphocytes (HP:0001922)2.61357446
73Xanthomatosis (HP:0000991)2.61353003
74Chronic obstructive pulmonary disease (HP:0006510)2.59271899
75Obstructive lung disease (HP:0006536)2.59271899
76Abnormality of the nasal mucosa (HP:0000433)2.59246338
77Nasal polyposis (HP:0100582)2.58571078
78Fragile nails (HP:0001808)2.58190584
79Increased cerebral lipofuscin (HP:0011813)2.57760152
80Dehydration (HP:0001944)2.57304514
81IgA deficiency (HP:0002720)2.57256018
82Recurrent bronchitis (HP:0002837)2.57055176
83Abnormality of the pericardium (HP:0001697)2.54243508
84Abnormality of B cell number (HP:0010975)2.51917193
85Focal segmental glomerulosclerosis (HP:0000097)2.51902257
86Joint swelling (HP:0001386)2.50078592
87Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.48291864
88Abnormality of the endocardium (HP:0004306)2.46726959
89Recurrent cutaneous fungal infections (HP:0011370)2.46343236
90Chronic mucocutaneous candidiasis (HP:0002728)2.46343236
91Cardiovascular calcification (HP:0011915)2.46252607
92Widely patent fontanelles and sutures (HP:0004492)2.45065156
93Glomerulonephritis (HP:0000099)2.44600474
94Prolonged QT interval (HP:0001657)2.43646080
95Esophageal varix (HP:0002040)2.41978712
96Peritonitis (HP:0002586)2.40573717
97Progressive neurologic deterioration (HP:0002344)2.39339072
98Polyneuropathy (HP:0001271)2.35967479
99Thin bony cortex (HP:0002753)2.30478644
100Pulmonary embolism (HP:0002204)2.30155314
101Increased IgE level (HP:0003212)2.29484122
102Atrophic scars (HP:0001075)2.29132083
103Abnormality of polysaccharide metabolism (HP:0011012)2.28061461
104Abnormality of glycosaminoglycan metabolism (HP:0004371)2.28061461
105Abnormality of mucopolysaccharide metabolism (HP:0011020)2.28061461
106Glomerulopathy (HP:0100820)2.27806184
107Increased serum ferritin (HP:0003281)2.27581487
108Ketoacidosis (HP:0001993)2.27269388
109Broad metatarsal (HP:0001783)2.26665720
110Vertigo (HP:0002321)2.26205463
111Hypobetalipoproteinemia (HP:0003563)2.25010783
112Hypolipoproteinemia (HP:0010981)2.24893238
113Mucopolysacchariduria (HP:0008155)2.24490162
114Urinary glycosaminoglycan excretion (HP:0003541)2.24490162
115B lymphocytopenia (HP:0010976)2.23962416
116Hypercholesterolemia (HP:0003124)2.23643850
117Plantar hyperkeratosis (HP:0007556)2.21230347
118Abnormality of purine metabolism (HP:0004352)2.21074591
119Ankyloglossia (HP:0010296)2.20438931
120Urticaria (HP:0001025)2.20021152
121Eosinophilia (HP:0001880)2.19434711
122Woolly hair (HP:0002224)2.18226621
123Gingivitis (HP:0000230)2.18204715
124Intrahepatic cholestasis (HP:0001406)2.17605558
125Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.15715450
126Acanthocytosis (HP:0001927)2.15655254
127Abnormal tarsal ossification (HP:0008369)2.15234045
128Myocardial infarction (HP:0001658)2.15008341
129Parakeratosis (HP:0001036)2.12730657
130Abnormal delayed hypersensitivity skin test (HP:0002963)2.12444878
131Facial shape deformation (HP:0011334)2.11878134
132Potter facies (HP:0002009)2.11878134
133Abnormality of the gastric mucosa (HP:0004295)2.10349973
134Hyperphosphatemia (HP:0002905)2.09904636
135Basal ganglia calcification (HP:0002135)2.09605063
136Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.08778077
137Ventricular tachycardia (HP:0004756)2.08629691
138Hypoalphalipoproteinemia (HP:0003233)2.07403303
139Keratitis (HP:0000491)2.07264508
140Autoimmune hemolytic anemia (HP:0001890)2.06507510
141Toxemia of pregnancy (HP:0100603)2.04627279
142Arthralgia (HP:0002829)2.04421574
143Cerebral ischemia (HP:0002637)2.03600930
144Hypoplasia of dental enamel (HP:0006297)2.02219927
145Episodic fever (HP:0001954)2.02059633
146Acne (HP:0001061)1.97544503
147Abnormality of the prostate (HP:0008775)1.97452232
148Enlarged epiphyses (HP:0010580)1.97434341
149Memory impairment (HP:0002354)1.95373852
150Thrombophlebitis (HP:0004418)1.95118480
151Biliary tract neoplasm (HP:0100574)1.93538407
152Eczematoid dermatitis (HP:0000976)1.90151542
153Abnormality of the 1st metacarpal (HP:0010009)1.88758726
154Dysostosis multiplex (HP:0000943)1.87849086
155Mildly elevated creatine phosphokinase (HP:0008180)1.86838923
156Bronchomalacia (HP:0002780)1.84320038
157Fat malabsorption (HP:0002630)1.84310667
158Sensorimotor neuropathy (HP:0007141)1.84258027
159Inflammation of the large intestine (HP:0002037)1.83602118
160Hemorrhage of the eye (HP:0011885)1.83379291
161Acanthosis nigricans (HP:0000956)1.83252458
162Abnormality of chloride homeostasis (HP:0011422)1.79355363
163Complement deficiency (HP:0004431)1.79138923
164Colitis (HP:0002583)1.78162011
165Glomerulosclerosis (HP:0000096)1.77036766
166Abnormal glucose tolerance (HP:0001952)1.75611581
167Multifactorial inheritance (HP:0001426)1.75556445
168Late onset (HP:0003584)1.73608412
169Stomach cancer (HP:0012126)1.72454643
170Ventricular fibrillation (HP:0001663)1.70839385
171Conjugated hyperbilirubinemia (HP:0002908)1.70800566
172Ventricular arrhythmia (HP:0004308)1.69491755
173Interstitial pulmonary disease (HP:0006530)1.66496189
174Progressive hearing impairment (HP:0001730)1.66207466
175Gastrointestinal inflammation (HP:0004386)1.65175955
176Neoplasm of the small intestine (HP:0100833)1.65103917
177Gastrointestinal stroma tumor (HP:0100723)1.64972250
178Hoarse voice (HP:0001609)1.64786936
179Proximal tubulopathy (HP:0000114)1.64274211
180Neoplasm of the rectum (HP:0100743)1.63941426
181Abnormality of the distal phalanx of the thumb (HP:0009617)1.63605958
182Hypertriglyceridemia (HP:0002155)1.63204304
183Rectal prolapse (HP:0002035)1.62678324
184Progressive sensorineural hearing impairment (HP:0000408)1.61435041
185Distal lower limb amyotrophy (HP:0008944)1.60435557
186Hypoglycemic coma (HP:0001325)1.59987014
187Syncope (HP:0001279)1.59247207

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R7.85362807
2PIK3CA5.31309964
3IRAK34.63599505
4MAP3K23.85533343
5EPHA23.82979937
6MST43.80391763
7JAK33.17066918
8KSR22.95354797
9MET2.93655979
10FRK2.72043961
11MAP2K22.70166510
12ADRBK22.48578841
13EPHA42.20831021
14IRAK42.14838884
15NME12.13916573
16PRPF4B2.12844583
17LMTK22.10271278
18IKBKB2.03656705
19TAOK21.91179354
20MAP2K11.80820413
21TXK1.80541716
22CDC42BPA1.75926492
23MAP4K11.72527553
24NME21.63755480
25RIPK41.58931489
26EPHB11.58054993
27PRKG21.48705554
28TESK11.47660153
29PIM21.46471046
30ERN11.35810156
31BLK1.34214229
32CHUK1.30905614
33RIPK11.28321495
34PTK61.25730390
35DMPK1.18201403
36STK391.16748196
37MAP3K11.16025066
38FER1.12346271
39ZAP701.10497023
40MOS1.08826359
41FGFR41.06761932
42TYRO31.03572624
43LYN1.02324540
44RET1.00871364
45CAMK2D0.97717342
46TAOK10.97297413
47MAPKAPK50.89186932
48MAP3K110.88545143
49FGFR20.87962129
50GRK60.87672258
51MAP3K120.84823565
52SYK0.84001142
53JAK20.82887794
54CLK10.82026627
55BMX0.81038789
56FGFR30.80003367
57PTK20.79793493
58EPHA30.79188113
59AKT30.76193773
60NLK0.73803313
61OXSR10.73167788
62LCK0.73005813
63IRAK20.72996191
64MAP3K50.71287540
65ACVR1B0.71086546
66SIK30.69315694
67DYRK30.69288362
68LRRK20.68052827
69HIPK20.62209834
70TBK10.60802960
71MAP3K90.59091014
72PKN10.58966862
73IKBKE0.58481726
74CDK60.56671439
75STK100.56286008
76MAP3K130.56154888
77BTK0.54985665
78PIM10.54431103
79HCK0.53604732
80MARK30.52969208
81TAOK30.52747706
82NTRK30.52546341
83SIK10.52186234
84PDGFRA0.51373475
85NEK90.51082943
86CDK50.49834457
87TYK20.49100681
88MATK0.48521437
89EPHB20.48475246
90JAK10.47099661
91MAP3K30.45556768
92EGFR0.45096123
93CAMK2B0.44432772
94SRC0.40810932
95CDK190.40213873
96MAP3K70.39880868
97KIT0.39646819
98PDK10.39058700
99PTK2B0.38200639
100FYN0.38093458
101MAP2K60.38003973
102DDR20.37459552
103MYLK0.36998525
104PAK40.36956856
105CAMK1D0.36482010
106GRK70.36249427
107CDK90.35809952
108PKN20.34465807
109TRIB30.34040435
110CAMK2G0.33814029
111CSF1R0.33700958
112PRKAA20.33155895
113DAPK20.32052923
114DAPK30.31871965
115PRKCQ0.31502310
116LATS20.31498787
117ABL10.30675969
118TNK20.29862955
119ALK0.29773046
120CSK0.29185024
121CDK40.29026699
122ARAF0.28822612
123PRKCH0.28737281
124PDPK10.28190278
125ABL20.27908020
126CAMKK10.27720614
127RPS6KA50.27286539
128PDGFRB0.27264595
129TESK20.27240362
130PRKCI0.26712936
131MAP3K80.26172726
132INSR0.25788093
133PRKCA0.24798047
134PRKACG0.24656060
135MAP2K30.23939578
136MAP3K140.23346112
137TGFBR20.23112831
138IGF1R0.22917700
139STK240.22526978
140BMPR20.21415128
141MAPK110.21067041
142ERBB20.20778997
143PRKCE0.20607228
144ERBB30.20040783
145FGR0.20029129
146IRAK10.19836422
147FES0.19607207
148YES10.19371235
149PRKCD0.18113150
150MINK10.17853085
151MAPK70.17729456
152MAPK40.14288898
153EIF2AK20.12671396
154MAPK30.12184862
155CDK140.11929162
156MAPKAPK20.11638474
157DAPK10.11441374
158CDK150.10313060
159DYRK1B0.08345058

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053304.24770884
2Toll-like receptor signaling pathway_Homo sapiens_hsa046203.57145746
3Autoimmune thyroid disease_Homo sapiens_hsa053203.29341304
4Nitrogen metabolism_Homo sapiens_hsa009103.28828718
5Asthma_Homo sapiens_hsa053103.24596648
6Graft-versus-host disease_Homo sapiens_hsa053323.23551086
7Intestinal immune network for IgA production_Homo sapiens_hsa046723.19893016
8Sulfur metabolism_Homo sapiens_hsa009203.16507738
9Mineral absorption_Homo sapiens_hsa049783.01758786
10Type I diabetes mellitus_Homo sapiens_hsa049402.98105755
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.93926318
12RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.70934821
13NF-kappa B signaling pathway_Homo sapiens_hsa040642.68190906
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.63523719
15Staphylococcus aureus infection_Homo sapiens_hsa051502.55843194
16Thyroid hormone synthesis_Homo sapiens_hsa049182.49021452
17Rheumatoid arthritis_Homo sapiens_hsa053232.42719934
18Osteoclast differentiation_Homo sapiens_hsa043802.31429045
19Fat digestion and absorption_Homo sapiens_hsa049752.27444958
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.24725335
21Salivary secretion_Homo sapiens_hsa049702.20308266
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.17298207
23Influenza A_Homo sapiens_hsa051642.13188740
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.07573543
25TNF signaling pathway_Homo sapiens_hsa046681.96720271
26Tuberculosis_Homo sapiens_hsa051521.94281375
27Viral myocarditis_Homo sapiens_hsa054161.92222098
28Antigen processing and presentation_Homo sapiens_hsa046121.89130193
29Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.88162148
30Herpes simplex infection_Homo sapiens_hsa051681.82713667
31Glutathione metabolism_Homo sapiens_hsa004801.81638214
32Malaria_Homo sapiens_hsa051441.80251051
33Legionellosis_Homo sapiens_hsa051341.79891963
34Measles_Homo sapiens_hsa051621.78587785
35Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.75056423
36Bile secretion_Homo sapiens_hsa049761.67246059
37Arginine biosynthesis_Homo sapiens_hsa002201.64820245
38Chemokine signaling pathway_Homo sapiens_hsa040621.58197708
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.56891326
40Glycerolipid metabolism_Homo sapiens_hsa005611.45481001
41Renin-angiotensin system_Homo sapiens_hsa046141.44491157
42Caffeine metabolism_Homo sapiens_hsa002321.43679499
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.42192110
44Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.34598304
45Lysosome_Homo sapiens_hsa041421.34319080
46PPAR signaling pathway_Homo sapiens_hsa033201.31165923
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.28600502
48Primary immunodeficiency_Homo sapiens_hsa053401.28041293
49Arachidonic acid metabolism_Homo sapiens_hsa005901.26366347
50Histidine metabolism_Homo sapiens_hsa003401.26123828
51Other glycan degradation_Homo sapiens_hsa005111.22221096
52Fructose and mannose metabolism_Homo sapiens_hsa000511.20545949
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.20374563
54Carbohydrate digestion and absorption_Homo sapiens_hsa049731.18175930
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.13469426
56Hematopoietic cell lineage_Homo sapiens_hsa046401.13175435
57Galactose metabolism_Homo sapiens_hsa000521.09620907
58Cocaine addiction_Homo sapiens_hsa050301.07950055
59Renin secretion_Homo sapiens_hsa049241.05082577
60Thyroid cancer_Homo sapiens_hsa052161.04894700
61Hepatitis B_Homo sapiens_hsa051611.04651249
62Long-term potentiation_Homo sapiens_hsa047201.04276502
63Starch and sucrose metabolism_Homo sapiens_hsa005001.03222987
64Fatty acid degradation_Homo sapiens_hsa000711.00965973
65Phagosome_Homo sapiens_hsa041451.00646604
66Leukocyte transendothelial migration_Homo sapiens_hsa046700.99602272
67B cell receptor signaling pathway_Homo sapiens_hsa046620.97656960
68Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.95628662
69Salmonella infection_Homo sapiens_hsa051320.94957424
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.94623231
71Apoptosis_Homo sapiens_hsa042100.89239749
72Epstein-Barr virus infection_Homo sapiens_hsa051690.88097291
73Shigellosis_Homo sapiens_hsa051310.87332528
74Gastric acid secretion_Homo sapiens_hsa049710.87305340
75Bladder cancer_Homo sapiens_hsa052190.86698637
76Prolactin signaling pathway_Homo sapiens_hsa049170.85596579
77Folate biosynthesis_Homo sapiens_hsa007900.81429088
78Tight junction_Homo sapiens_hsa045300.81178724
79Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.79813231
80Circadian entrainment_Homo sapiens_hsa047130.76257840
81Phenylalanine metabolism_Homo sapiens_hsa003600.76229973
82Hepatitis C_Homo sapiens_hsa051600.75801574
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.75453709
84Gap junction_Homo sapiens_hsa045400.74903686
85Amphetamine addiction_Homo sapiens_hsa050310.74423397
86Pertussis_Homo sapiens_hsa051330.73806585
87Vitamin digestion and absorption_Homo sapiens_hsa049770.73468872
88* African trypanosomiasis_Homo sapiens_hsa051430.72089791
89Amoebiasis_Homo sapiens_hsa051460.71731052
90Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.71620767
91Butanoate metabolism_Homo sapiens_hsa006500.71529813
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69647112
93Dorso-ventral axis formation_Homo sapiens_hsa043200.69340384
94ABC transporters_Homo sapiens_hsa020100.69201970
95Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.68578761
96Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.68046184
97GnRH signaling pathway_Homo sapiens_hsa049120.67185119
98Pancreatic secretion_Homo sapiens_hsa049720.65967928
99Olfactory transduction_Homo sapiens_hsa047400.65814828
100Acute myeloid leukemia_Homo sapiens_hsa052210.63073143
101beta-Alanine metabolism_Homo sapiens_hsa004100.62332220
102Fatty acid biosynthesis_Homo sapiens_hsa000610.61677252
103Leishmaniasis_Homo sapiens_hsa051400.61459294
104Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61425185
105* Tryptophan metabolism_Homo sapiens_hsa003800.61137452
106AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61089072
107Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57533320
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56922810
109Systemic lupus erythematosus_Homo sapiens_hsa053220.55881101
110Type II diabetes mellitus_Homo sapiens_hsa049300.55599117
111Cholinergic synapse_Homo sapiens_hsa047250.55043362
112Protein digestion and absorption_Homo sapiens_hsa049740.54957926
113Fatty acid metabolism_Homo sapiens_hsa012120.54787613
114T cell receptor signaling pathway_Homo sapiens_hsa046600.52833324
115Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50562487
116Pyruvate metabolism_Homo sapiens_hsa006200.50427882
117Toxoplasmosis_Homo sapiens_hsa051450.49406593
118Oxytocin signaling pathway_Homo sapiens_hsa049210.49321756
119Prion diseases_Homo sapiens_hsa050200.48972220
120Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47946443
121GABAergic synapse_Homo sapiens_hsa047270.47521336
122Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46434471
123Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46075352
124Vibrio cholerae infection_Homo sapiens_hsa051100.45877239
125Dopaminergic synapse_Homo sapiens_hsa047280.45809159
126Alzheimers disease_Homo sapiens_hsa050100.45681420
127Propanoate metabolism_Homo sapiens_hsa006400.43868400
128Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43725340
129HTLV-I infection_Homo sapiens_hsa051660.43157009
130Insulin secretion_Homo sapiens_hsa049110.42997076
131Maturity onset diabetes of the young_Homo sapiens_hsa049500.42852591
132Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42645385
133Adherens junction_Homo sapiens_hsa045200.42573896
134Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.42485825
135alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42402976
136Glutamatergic synapse_Homo sapiens_hsa047240.42204451
137Adipocytokine signaling pathway_Homo sapiens_hsa049200.41958661
138Platelet activation_Homo sapiens_hsa046110.41842532
139Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.41714162
140Arginine and proline metabolism_Homo sapiens_hsa003300.41704628
141Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40892677
142NOD-like receptor signaling pathway_Homo sapiens_hsa046210.40193181
143Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39908431
144Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39267104
145Glycerophospholipid metabolism_Homo sapiens_hsa005640.39222214
146Estrogen signaling pathway_Homo sapiens_hsa049150.39029620
147Calcium signaling pathway_Homo sapiens_hsa040200.38619069
148Carbon metabolism_Homo sapiens_hsa012000.38439162
149Morphine addiction_Homo sapiens_hsa050320.38420026
150Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37823788
151Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.35136860
152Viral carcinogenesis_Homo sapiens_hsa052030.30689986
153SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26716386
154Pancreatic cancer_Homo sapiens_hsa052120.25558608
155Complement and coagulation cascades_Homo sapiens_hsa046100.24698847
156Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24359170
157Collecting duct acid secretion_Homo sapiens_hsa049660.23735272
158Sphingolipid metabolism_Homo sapiens_hsa006000.22882957
159Notch signaling pathway_Homo sapiens_hsa043300.21322409
160Sphingolipid signaling pathway_Homo sapiens_hsa040710.19665084
161HIF-1 signaling pathway_Homo sapiens_hsa040660.19611098
162Insulin resistance_Homo sapiens_hsa049310.15800538
163VEGF signaling pathway_Homo sapiens_hsa043700.15594374
164Neurotrophin signaling pathway_Homo sapiens_hsa047220.14438422
165FoxO signaling pathway_Homo sapiens_hsa040680.11638833
166Chronic myeloid leukemia_Homo sapiens_hsa052200.08182334
167Endocytosis_Homo sapiens_hsa041440.07168882
168Small cell lung cancer_Homo sapiens_hsa052220.05505509
169Ether lipid metabolism_Homo sapiens_hsa005650.00897183
170Prostate cancer_Homo sapiens_hsa05215-0.0278696
171Renal cell carcinoma_Homo sapiens_hsa05211-0.0056731

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