IDO2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Along with the enzymes encoded by the INDO (MIM 147435) and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway (Ball et al., 2007 [PubMed 17499941]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.64879184
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.64879184
3L-phenylalanine metabolic process (GO:0006558)7.32060649
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.32060649
5* aromatic amino acid family catabolic process (GO:0009074)6.84815187
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.28162284
7* indole-containing compound catabolic process (GO:0042436)6.11004926
8* indolalkylamine catabolic process (GO:0046218)6.11004926
9* tryptophan catabolic process (GO:0006569)6.11004926
10bile acid biosynthetic process (GO:0006699)6.08446446
11* kynurenine metabolic process (GO:0070189)5.88491103
12glyoxylate metabolic process (GO:0046487)5.83783881
13* tryptophan metabolic process (GO:0006568)5.72440112
14urea metabolic process (GO:0019627)5.69045297
15urea cycle (GO:0000050)5.69045297
16alpha-linolenic acid metabolic process (GO:0036109)5.65072857
17negative regulation of fibrinolysis (GO:0051918)5.58824707
18high-density lipoprotein particle remodeling (GO:0034375)5.52589608
19behavioral response to nicotine (GO:0035095)5.43399003
20regulation of fibrinolysis (GO:0051917)5.43062001
21protein carboxylation (GO:0018214)5.42716029
22peptidyl-glutamic acid carboxylation (GO:0017187)5.42716029
23sulfur amino acid catabolic process (GO:0000098)5.42636945
24complement activation, alternative pathway (GO:0006957)5.41224896
25regulation of protein activation cascade (GO:2000257)5.39339274
26cysteine metabolic process (GO:0006534)5.33575125
27nitrogen cycle metabolic process (GO:0071941)5.23426623
28serine family amino acid catabolic process (GO:0009071)5.21167800
29bile acid metabolic process (GO:0008206)5.19908889
30regulation of complement activation (GO:0030449)5.05375146
31fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.92843932
32* aromatic amino acid family metabolic process (GO:0009072)4.90279295
33tyrosine metabolic process (GO:0006570)4.82819113
34reverse cholesterol transport (GO:0043691)4.79499072
35regulation of triglyceride catabolic process (GO:0010896)4.78439656
36regulation of cholesterol esterification (GO:0010872)4.78287434
37homocysteine metabolic process (GO:0050667)4.72756091
38protein-lipid complex remodeling (GO:0034368)4.69106263
39macromolecular complex remodeling (GO:0034367)4.69106263
40plasma lipoprotein particle remodeling (GO:0034369)4.69106263
41lysine catabolic process (GO:0006554)4.68170844
42lysine metabolic process (GO:0006553)4.68170844
43* alpha-amino acid catabolic process (GO:1901606)4.68102790
44triglyceride homeostasis (GO:0070328)4.65646339
45acylglycerol homeostasis (GO:0055090)4.65646339
46amino-acid betaine metabolic process (GO:0006577)4.62618838
47coenzyme catabolic process (GO:0009109)4.61647584
48negative regulation of cholesterol transport (GO:0032375)4.56279866
49negative regulation of sterol transport (GO:0032372)4.56279866
50DNA deamination (GO:0045006)4.56011260
51phospholipid efflux (GO:0033700)4.52881350
52cellular ketone body metabolic process (GO:0046950)4.51750685
53bile acid and bile salt transport (GO:0015721)4.50160575
54glycine metabolic process (GO:0006544)4.49481076
55imidazole-containing compound metabolic process (GO:0052803)4.47604112
56cellular glucuronidation (GO:0052695)4.34513375
57* cellular amino acid catabolic process (GO:0009063)4.31019308
58plasma lipoprotein particle clearance (GO:0034381)4.29482412
59fucose catabolic process (GO:0019317)4.28086357
60L-fucose metabolic process (GO:0042354)4.28086357
61L-fucose catabolic process (GO:0042355)4.28086357
62glutamate metabolic process (GO:0006536)4.27581374
63serine family amino acid metabolic process (GO:0009069)4.23121194
64* indolalkylamine metabolic process (GO:0006586)4.21964992
65ethanol oxidation (GO:0006069)4.21588763
66cholesterol efflux (GO:0033344)4.14987468
67cellular modified amino acid catabolic process (GO:0042219)4.13261823
68platelet dense granule organization (GO:0060155)4.12969183
69* cellular biogenic amine catabolic process (GO:0042402)4.12663627
70* amine catabolic process (GO:0009310)4.12663627
71dicarboxylic acid biosynthetic process (GO:0043650)4.11487649
72arginine metabolic process (GO:0006525)4.09205499
73drug catabolic process (GO:0042737)4.06176279
74fibrinolysis (GO:0042730)4.04553304
75serine family amino acid biosynthetic process (GO:0009070)4.03611180
76aldehyde catabolic process (GO:0046185)4.01367255
77* benzene-containing compound metabolic process (GO:0042537)3.97295738
78low-density lipoprotein particle remodeling (GO:0034374)3.95206877
79ketone body metabolic process (GO:1902224)3.90599822
80plasma lipoprotein particle assembly (GO:0034377)3.89214042
81cofactor catabolic process (GO:0051187)3.87280085
82complement activation, classical pathway (GO:0006958)3.86605297
83glucuronate metabolic process (GO:0019585)3.85850374
84uronic acid metabolic process (GO:0006063)3.85850374
85blood coagulation, intrinsic pathway (GO:0007597)3.85434201
86cytolysis (GO:0019835)3.85145379
87complement activation (GO:0006956)3.79665047
88regulation of bile acid biosynthetic process (GO:0070857)3.78423924
89positive regulation of lipoprotein lipase activity (GO:0051006)3.78004841
90positive regulation of triglyceride lipase activity (GO:0061365)3.78004841
91protein activation cascade (GO:0072376)3.75752296
92* organic acid catabolic process (GO:0016054)3.75198048
93* carboxylic acid catabolic process (GO:0046395)3.75198048
94NAD biosynthetic process (GO:0009435)3.74381466
95acetyl-CoA metabolic process (GO:0006084)3.73024462
96negative regulation of lipase activity (GO:0060192)3.72374309
97very-low-density lipoprotein particle assembly (GO:0034379)3.71116129
98cholesterol homeostasis (GO:0042632)3.71013788
99short-chain fatty acid metabolic process (GO:0046459)3.70994320
100phospholipid homeostasis (GO:0055091)3.68644657
101pyridine nucleotide biosynthetic process (GO:0019363)3.67651709
102nicotinamide nucleotide biosynthetic process (GO:0019359)3.67651709
103regulation of cholesterol homeostasis (GO:2000188)3.67188221
104positive regulation of lipid catabolic process (GO:0050996)3.65283352
105sterol homeostasis (GO:0055092)3.65234592
106exogenous drug catabolic process (GO:0042738)3.59144473
107response to pheromone (GO:0019236)3.37815574
108positive regulation of defense response to virus by host (GO:0002230)3.21794621
109detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.05660759
110detection of light stimulus involved in visual perception (GO:0050908)3.05354644
111detection of light stimulus involved in sensory perception (GO:0050962)3.05354644
112water-soluble vitamin biosynthetic process (GO:0042364)3.04233721
113respiratory chain complex IV assembly (GO:0008535)3.01531537
114negative regulation of mast cell activation (GO:0033004)3.00983379
115epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.99555972
116protein localization to cilium (GO:0061512)2.94202659
117sulfation (GO:0051923)2.92794478
118cytidine metabolic process (GO:0046087)2.92463342
119cytidine catabolic process (GO:0006216)2.92463342
120cytidine deamination (GO:0009972)2.92463342
121axoneme assembly (GO:0035082)2.91860190
122preassembly of GPI anchor in ER membrane (GO:0016254)2.91597211
123mannosylation (GO:0097502)2.90403354
124neural tube formation (GO:0001841)2.88408979
125multicellular organism reproduction (GO:0032504)2.84790807
126S-adenosylmethionine metabolic process (GO:0046500)2.84763154
127parturition (GO:0007567)2.84096103
128synaptic transmission, cholinergic (GO:0007271)2.83921669
129cellular response to ATP (GO:0071318)2.83610307
130negative regulation of telomere maintenance (GO:0032205)2.81544460
131piRNA metabolic process (GO:0034587)2.79603323
132protein complex biogenesis (GO:0070271)2.79297564
133gamma-aminobutyric acid transport (GO:0015812)2.78883725
134protein-cofactor linkage (GO:0018065)2.78505403
135* indole-containing compound metabolic process (GO:0042430)2.74693645
136epithelial cilium movement (GO:0003351)2.74057443
137neuronal action potential (GO:0019228)2.73269153
138positive regulation of fatty acid transport (GO:2000193)2.70997011
139ubiquinone biosynthetic process (GO:0006744)2.70900343
140regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.70094666
141cytochrome complex assembly (GO:0017004)2.67770248
142positive regulation of T-helper 1 type immune response (GO:0002827)2.67390500
143oxidative demethylation (GO:0070989)2.65593966
144phosphatidylinositol acyl-chain remodeling (GO:0036149)2.63301866
145adaptation of signaling pathway (GO:0023058)2.59155360
146protein polyglutamylation (GO:0018095)2.58587672
147positive regulation of prostaglandin secretion (GO:0032308)2.56978917
148pyrimidine ribonucleoside catabolic process (GO:0046133)2.55156396
149glycerophospholipid catabolic process (GO:0046475)2.54151864
150sulfate transmembrane transport (GO:1902358)2.53998046
151kidney morphogenesis (GO:0060993)2.53257018
152ubiquinone metabolic process (GO:0006743)2.52750836
153dopamine transport (GO:0015872)2.51354986
154cornea development in camera-type eye (GO:0061303)2.51347412
155mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.49142854
156mitochondrial respiratory chain complex I assembly (GO:0032981)2.49142854
157NADH dehydrogenase complex assembly (GO:0010257)2.49142854
158mitochondrial respiratory chain complex assembly (GO:0033108)2.47480944
159cilium morphogenesis (GO:0060271)2.47159934
160mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.47031536
161cAMP catabolic process (GO:0006198)2.45815025
162estrogen biosynthetic process (GO:0006703)2.43739526
163reflex (GO:0060004)2.43099557
164behavioral response to ethanol (GO:0048149)2.42556598
165phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.42195013
166rRNA catabolic process (GO:0016075)2.40929804
167positive regulation of cAMP-mediated signaling (GO:0043950)2.40855304
168regulation of cilium movement (GO:0003352)2.38053207
169primary amino compound metabolic process (GO:1901160)2.37675301
170signal peptide processing (GO:0006465)2.37555179
171adenosine metabolic process (GO:0046085)2.35572718
172phosphatidylserine acyl-chain remodeling (GO:0036150)2.35026015
173positive regulation of icosanoid secretion (GO:0032305)2.33465097
174G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.31574910
175regulation of action potential (GO:0098900)2.30987268
176negative regulation of synaptic transmission, GABAergic (GO:0032229)2.30809160
177auditory receptor cell stereocilium organization (GO:0060088)2.29799245
178regulation of glucokinase activity (GO:0033131)2.29161411
179regulation of hexokinase activity (GO:1903299)2.29161411
180negative regulation of reactive oxygen species metabolic process (GO:2000378)2.29075044
181photoreceptor cell maintenance (GO:0045494)2.28779096
182photoreceptor cell development (GO:0042461)2.27740583
183DNA methylation involved in gamete generation (GO:0043046)2.26965425
184nephron tubule morphogenesis (GO:0072078)2.26089138
185nephron epithelium morphogenesis (GO:0072088)2.26089138
186regulation of memory T cell differentiation (GO:0043380)2.25810123

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.41673400
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.19781661
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.13435996
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.48383563
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.31908145
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.04760867
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.73837875
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.07944528
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.01227527
10ZNF274_21170338_ChIP-Seq_K562_Hela3.73514700
11VDR_22108803_ChIP-Seq_LS180_Human3.48295847
12GBX2_23144817_ChIP-Seq_PC3_Human2.66488727
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.52648791
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.49260366
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.31531830
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.27517962
17EZH2_22144423_ChIP-Seq_EOC_Human2.23239965
18IGF1R_20145208_ChIP-Seq_DFB_Human2.14789624
19POU3F2_20337985_ChIP-ChIP_501MEL_Human2.10406579
20TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.05293594
21CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02720193
22ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.9600008
23CTBP2_25329375_ChIP-Seq_LNCAP_Human1.95130316
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.93180865
25HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.92769569
26P300_19829295_ChIP-Seq_ESCs_Human1.87208286
27TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.87205188
28ER_23166858_ChIP-Seq_MCF-7_Human1.85211899
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.79621732
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.76844090
31FUS_26573619_Chip-Seq_HEK293_Human1.76745295
32* EWS_26573619_Chip-Seq_HEK293_Human1.76561733
33HTT_18923047_ChIP-ChIP_STHdh_Human1.58961625
34FOXA2_19822575_ChIP-Seq_HepG2_Human1.57496259
35* TP53_22573176_ChIP-Seq_HFKS_Human1.54071127
36UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.53584158
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.48964551
38FOXA1_27270436_Chip-Seq_PROSTATE_Human1.48940411
39FOXA1_25329375_ChIP-Seq_VCAP_Human1.48940411
40IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44847815
41CBP_20019798_ChIP-Seq_JUKART_Human1.44847815
42AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.44235614
43NANOG_19829295_ChIP-Seq_ESCs_Human1.42274623
44SOX2_19829295_ChIP-Seq_ESCs_Human1.42274623
45HNF4A_19822575_ChIP-Seq_HepG2_Human1.41229571
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40491897
47MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39358104
48PCGF2_27294783_Chip-Seq_NPCs_Mouse1.37555042
49STAT3_23295773_ChIP-Seq_U87_Human1.36811123
50EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.36736375
51CLOCK_20551151_ChIP-Seq_293T_Human1.35574397
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35076971
53* AR_25329375_ChIP-Seq_VCAP_Human1.34881067
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.34804310
55SUZ12_27294783_Chip-Seq_NPCs_Mouse1.34710323
56NFE2_27457419_Chip-Seq_LIVER_Mouse1.32262325
57TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32115382
58GATA3_21878914_ChIP-Seq_MCF-7_Human1.30490122
59NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30196498
60GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.29944305
61THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.29658928
62ETV2_25802403_ChIP-Seq_MESCs_Mouse1.29208552
63FOXA1_21572438_ChIP-Seq_LNCaP_Human1.27957718
64SMAD4_21799915_ChIP-Seq_A2780_Human1.27196171
65GATA1_22025678_ChIP-Seq_K562_Human1.26325631
66MYC_18940864_ChIP-ChIP_HL60_Human1.25703428
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.25665263
68TCF4_23295773_ChIP-Seq_U87_Human1.25579939
69GABP_17652178_ChIP-ChIP_JURKAT_Human1.25497557
70REST_21632747_ChIP-Seq_MESCs_Mouse1.25451871
71STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.25187603
72PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25118045
73RXRA_24833708_ChIP-Seq_LIVER_Mouse1.24862331
74* TCF4_22108803_ChIP-Seq_LS180_Human1.24066086
75EZH2_27294783_Chip-Seq_NPCs_Mouse1.23761545
76RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23140376
77SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22284927
78POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19212757
79TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19212757
80TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18917819
81SMAD3_21741376_ChIP-Seq_EPCs_Human1.18399358
82MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18367318
83RUNX2_22187159_ChIP-Seq_PCA_Human1.16313209
84STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.15357210
85CBX2_27304074_Chip-Seq_ESCs_Mouse1.15013924
86KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14840156
87SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13875538
88STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.13665232
89PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12948902
90MYC_19829295_ChIP-Seq_ESCs_Human1.11638594
91HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.11233869
92SMAD4_21741376_ChIP-Seq_EPCs_Human1.11129763
93IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.10388158
94IRF8_21731497_ChIP-ChIP_J774_Mouse1.09804642
95* PRDM14_20953172_ChIP-Seq_ESCs_Human1.09675122
96HOXB7_26014856_ChIP-Seq_BT474_Human1.09609907
97GATA3_26560356_Chip-Seq_TH2_Human1.09540313
98CRX_20693478_ChIP-Seq_RETINA_Mouse1.08457001
99RNF2_27304074_Chip-Seq_NSC_Mouse1.07669958
100FLI1_21867929_ChIP-Seq_TH2_Mouse1.07172303
101LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.04325940
102P53_22387025_ChIP-Seq_ESCs_Mouse1.03923901
103EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03703849
104KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.03557220
105NANOG_18555785_Chip-Seq_ESCs_Mouse1.03197315
106ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01918122
107EST1_17652178_ChIP-ChIP_JURKAT_Human1.01036870
108NANOG_20526341_ChIP-Seq_ESCs_Human1.00111607
109SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99899362
110ESR1_15608294_ChIP-ChIP_MCF-7_Human0.98596959
111STAT3_18555785_Chip-Seq_ESCs_Mouse0.98366916
112GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.98061443
113SOX2_27498859_Chip-Seq_STOMACH_Mouse0.87162013
114PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.85554834
115TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.85406847
116IRF8_22096565_ChIP-ChIP_GC-B_Human0.85362071
117KAP1_22055183_ChIP-Seq_ESCs_Mouse0.82348061
118AUTS2_25519132_ChIP-Seq_293T-REX_Human0.81721725
119GATA4_25053715_ChIP-Seq_YYC3_Human0.79805438
120ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.78016416
121RARA_24833708_ChIP-Seq_LIVER_Mouse0.76323823
122SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.72862508
123Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.72547758
124ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.72221643
125SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.71534768
126BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.70896397
127CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.66616803
128* RARG_19884340_ChIP-ChIP_MEFs_Mouse0.65517772
129RARB_24833708_ChIP-Seq_LIVER_Mouse0.65375313
130SALL4_18804426_ChIP-ChIP_XEN_Mouse0.65022116
131AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.64628447
132NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.64447704
133RAD21_21589869_ChIP-Seq_MESCs_Mouse0.64349372
134BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.64294024
135ESR2_21235772_ChIP-Seq_MCF-7_Human0.62527047
136NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.61890642
137NRF2_20460467_ChIP-Seq_MEFs_Mouse0.61890642
138RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.60826893
139NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.60335878
140NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.59396587
141ZNF263_19887448_ChIP-Seq_K562_Human0.56695856
142LXR_22292898_ChIP-Seq_THP-1_Human0.56008032
143CEBPB_22108803_ChIP-Seq_LS180_Human0.54986513
144PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.54770499
145E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.54101525
146ESET_19884257_ChIP-Seq_ESCs_Mouse0.53727501
147CDX2_20551321_ChIP-Seq_CACO-2_Human0.53400534
148STAT3_1855785_ChIP-Seq_MESCs_Mouse0.51858421
149FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.51236502
150MYC_19915707_ChIP-ChIP_AK7_Human0.50834658
151GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.50358179
152STAT1_17558387_ChIP-Seq_HELA_Human0.49816977
153AR_20517297_ChIP-Seq_VCAP_Human0.49733424
154FOXA1_25552417_ChIP-Seq_VCAP_Human0.49482046
155ERG_21242973_ChIP-ChIP_JURKAT_Human0.48364572
156TAF15_26573619_Chip-Seq_HEK293_Human0.47976124
157EGR1_19032775_ChIP-ChIP_M12_Human0.47338021
158FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.47159136
159CBP_21632823_ChIP-Seq_H3396_Human0.46834961
160CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.43952866
161PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.43746615
162ESR1_21235772_ChIP-Seq_MCF-7_Human0.43728860
163* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.43316363
164P53_21459846_ChIP-Seq_SAOS-2_Human0.43215798
165STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.42112322
166SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.41853680
167TAF2_19829295_ChIP-Seq_ESCs_Human0.41457725
168GATA1_19941827_ChIP-Seq_MEL_Mouse0.41112851
169IRF1_19129219_ChIP-ChIP_H3396_Human0.40979300
170MYC_27129775_Chip-Seq_CORNEA_Mouse0.40521222
171ESR1_20079471_ChIP-ChIP_T-47D_Human0.39995035
172SPI1_26923725_Chip-Seq_HPCs_Mouse0.39888215
173BCAT_22108803_ChIP-Seq_LS180_Human0.39503335
174SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.38366319
175PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.36814780
176FOXO3_23340844_ChIP-Seq_DLD1_Human0.36174636
177GATA2_19941826_ChIP-Seq_K562_Human0.35570798
178FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.35128327
179LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.35071691
180FOXH1_21741376_ChIP-Seq_EPCs_Human0.35048498
181GATA1_19941826_ChIP-Seq_K562_Human0.35030091
182NCOR_22424771_ChIP-Seq_293T_Human0.34888959
183CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.34702429
184GATA6_25053715_ChIP-Seq_YYC3_Human0.34690867
185OCT4_20526341_ChIP-Seq_ESCs_Human0.34244332
186PPAR_26484153_Chip-Seq_NCI-H1993_Human0.33822733

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.37598459
2MP0005360_urolithiasis7.63853540
3MP0005085_abnormal_gallbladder_physiolo6.51737416
4MP0005365_abnormal_bile_salt6.21062218
5MP0008875_abnormal_xenobiotic_pharmacok5.14577225
6MP0003806_abnormal_nucleotide_metabolis4.33595044
7MP0003252_abnormal_bile_duct3.92599494
8MP0010329_abnormal_lipoprotein_level3.58986906
9MP0009840_abnormal_foam_cell3.20451742
10MP0005083_abnormal_biliary_tract3.10912264
11MP0003195_calcinosis2.83643603
12MP0005332_abnormal_amino_acid2.76330704
13MP0000569_abnormal_digit_pigmentation2.64424669
14MP0001666_abnormal_nutrient_absorption2.57579789
15MP0008877_abnormal_DNA_methylation2.39385743
16MP0005551_abnormal_eye_electrophysiolog2.33962743
17MP0003191_abnormal_cellular_cholesterol2.24396430
18MP0004019_abnormal_vitamin_homeostasis2.16305971
19MP0000609_abnormal_liver_physiology2.15426936
20MP0001968_abnormal_touch/_nociception2.10445567
21MP0002118_abnormal_lipid_homeostasis2.09700662
22MP0001501_abnormal_sleep_pattern2.09191723
23MP0002102_abnormal_ear_morphology2.01226507
24MP0003868_abnormal_feces_composition1.93460317
25MP0001986_abnormal_taste_sensitivity1.92713297
26MP0002138_abnormal_hepatobiliary_system1.91735286
27MP0003787_abnormal_imprinting1.88894505
28MP0005671_abnormal_response_to1.88368115
29MP0005319_abnormal_enzyme/_coenzyme1.85765343
30MP0006072_abnormal_retinal_apoptosis1.84331985
31MP0004142_abnormal_muscle_tone1.81704694
32MP0009745_abnormal_behavioral_response1.77458349
33MP0002638_abnormal_pupillary_reflex1.76348900
34MP0003646_muscle_fatigue1.75724108
35MP0009697_abnormal_copulation1.74591447
36MP0002653_abnormal_ependyma_morphology1.74228179
37MP0004043_abnormal_pH_regulation1.73015583
38MP0001764_abnormal_homeostasis1.69217965
39MP0005645_abnormal_hypothalamus_physiol1.69131791
40MP0003136_yellow_coat_color1.69059377
41MP0004885_abnormal_endolymph1.67565679
42MP0006292_abnormal_olfactory_placode1.65485732
43MP0003880_abnormal_central_pattern1.65268867
44MP0009046_muscle_twitch1.64535522
45MP0002736_abnormal_nociception_after1.64175583
46MP0005253_abnormal_eye_physiology1.64089913
47MP0005646_abnormal_pituitary_gland1.56345095
48MP0005584_abnormal_enzyme/coenzyme_acti1.55705103
49MP0002163_abnormal_gland_morphology1.52808804
50MP0006276_abnormal_autonomic_nervous1.49217894
51MP0000427_abnormal_hair_cycle1.45760842
52MP0002272_abnormal_nervous_system1.45317475
53MP0010386_abnormal_urinary_bladder1.44690863
54MP0005174_abnormal_tail_pigmentation1.43525355
55MP0005379_endocrine/exocrine_gland_phen1.41303905
56MP0003011_delayed_dark_adaptation1.38427401
57MP0005451_abnormal_body_composition1.37304252
58MP0004147_increased_porphyrin_level1.34121972
59MP0000372_irregular_coat_pigmentation1.33522456
60MP0005410_abnormal_fertilization1.28660620
61MP0001485_abnormal_pinna_reflex1.27384320
62MP0005389_reproductive_system_phenotype1.26244840
63MP0003186_abnormal_redox_activity1.26158200
64MP0009785_altered_susceptibility_to1.23765701
65MP0001835_abnormal_antigen_presentation1.22714066
66MP0005647_abnormal_sex_gland1.21925118
67MP0002148_abnormal_hypersensitivity_rea1.20551785
68MP0009643_abnormal_urine_homeostasis1.20474279
69MP0001919_abnormal_reproductive_system1.19840439
70MP0003656_abnormal_erythrocyte_physiolo1.19362259
71MP0000598_abnormal_liver_morphology1.15881779
72MP0002693_abnormal_pancreas_physiology1.14960716
73MP0002938_white_spotting1.14516646
74MP0000631_abnormal_neuroendocrine_gland1.11948695
75MP0001970_abnormal_pain_threshold1.11268567
76MP0002064_seizures1.10767993
77MP0003705_abnormal_hypodermis_morpholog1.10445778
78MP0002572_abnormal_emotion/affect_behav1.08560502
79MP0003878_abnormal_ear_physiology1.08478906
80MP0005377_hearing/vestibular/ear_phenot1.08478906
81MP0002733_abnormal_thermal_nociception1.08452765
82MP0004133_heterotaxia1.08046972
83MP0005387_immune_system_phenotype1.07764358
84MP0001790_abnormal_immune_system1.07764358
85MP0009764_decreased_sensitivity_to1.07688609
86MP0001486_abnormal_startle_reflex1.07189100
87MP0002277_abnormal_respiratory_mucosa1.06759087
88MP0004742_abnormal_vestibular_system1.06425677
89MP0002557_abnormal_social/conspecific_i1.05892386
90MP0002254_reproductive_system_inflammat1.05071098
91MP0001905_abnormal_dopamine_level1.04880124
92MP0000685_abnormal_immune_system1.02268037
93MP0000604_amyloidosis1.00358379
94MP0009763_increased_sensitivity_to0.99613447
95MP0001800_abnormal_humoral_immune0.99488026
96MP0004145_abnormal_muscle_electrophysio0.99180574
97MP0002160_abnormal_reproductive_system0.98454780
98MP0001984_abnormal_olfaction0.98413456
99MP0010368_abnormal_lymphatic_system0.96644583
100MP0002735_abnormal_chemical_nociception0.92134070
101MP0005386_behavior/neurological_phenoty0.90389004
102MP0004924_abnormal_behavior0.90389004
103MP0005636_abnormal_mineral_homeostasis0.89212942
104MP0008469_abnormal_protein_level0.88926166
105MP0002095_abnormal_skin_pigmentation0.87782611
106MP0002067_abnormal_sensory_capabilities0.87240380
107MP0005195_abnormal_posterior_eye0.86569294
108MP0009642_abnormal_blood_homeostasis0.86062288
109MP0001502_abnormal_circadian_rhythm0.83134071
110MP0002909_abnormal_adrenal_gland0.83037872
111MP0008995_early_reproductive_senescence0.82382600
112MP0002723_abnormal_immune_serum0.81995353
113MP0006036_abnormal_mitochondrial_physio0.80813660
114MP0005376_homeostasis/metabolism_phenot0.80185071
115MP0005408_hypopigmentation0.79801185
116MP0002876_abnormal_thyroid_physiology0.79482815
117MP0001873_stomach_inflammation0.79025962
118MP0005084_abnormal_gallbladder_morpholo0.76985534
119MP0002078_abnormal_glucose_homeostasis0.76513204
120MP0009765_abnormal_xenobiotic_induced0.75429418
121MP0001765_abnormal_ion_homeostasis0.74987232
122MP0005670_abnormal_white_adipose0.74426400
123MP0002063_abnormal_learning/memory/cond0.74263490
124MP0005075_abnormal_melanosome_morpholog0.71121853
125MP0002971_abnormal_brown_adipose0.68832924
126MP0005334_abnormal_fat_pad0.68122997
127MP0005220_abnormal_exocrine_pancreas0.68088027
128MP0005535_abnormal_body_temperature0.66970528
129MP0005266_abnormal_metabolism0.66571133
130MP0003690_abnormal_glial_cell0.66552148
131MP0001661_extended_life_span0.64056451
132MP0009053_abnormal_anal_canal0.62949705
133MP0000639_abnormal_adrenal_gland0.61967133
134MP0004130_abnormal_muscle_cell0.60160737
135MP0006035_abnormal_mitochondrial_morpho0.58111913
136MP0003329_amyloid_beta_deposits0.54992685
137MP0001756_abnormal_urination0.54300228
138MP0005448_abnormal_energy_balance0.53666133
139MP0004782_abnormal_surfactant_physiolog0.52203830
140MP0002822_catalepsy0.50916939
141MP0008874_decreased_physiological_sensi0.49748559
142MP0005248_abnormal_Harderian_gland0.49119729
143MP0003718_maternal_effect0.48475680
144MP0005395_other_phenotype0.48227151
145MP0003638_abnormal_response/metabolism_0.46543994
146MP0005464_abnormal_platelet_physiology0.46522449
147MP0004381_abnormal_hair_follicle0.46410883
148MP0002928_abnormal_bile_duct0.44947259
149MP0003075_altered_response_to0.42968822
150MP0002136_abnormal_kidney_physiology0.42863224
151MP0008873_increased_physiological_sensi0.41801574
152MP0003724_increased_susceptibility_to0.41143101
153MP0003436_decreased_susceptibility_to0.40829372
154MP0003953_abnormal_hormone_level0.40792332
155MP0005166_decreased_susceptibility_to0.40101229
156MP0008872_abnormal_physiological_respon0.39044602
157MP0006082_CNS_inflammation0.38049986
158MP0002837_dystrophic_cardiac_calcinosis0.34368806
159MP0009115_abnormal_fat_cell0.34159737
160MP0000579_abnormal_nail_morphology0.33657006
161MP0009672_abnormal_birth_weight0.33390461
162MP0002796_impaired_skin_barrier0.33142237
163MP0004883_abnormal_blood_vessel0.30518847
164MP0002168_other_aberrant_phenotype0.30499958
165MP0000249_abnormal_blood_vessel0.30499679
166MP0002132_abnormal_respiratory_system0.29798961
167MP0002970_abnormal_white_adipose0.29775264
168MP0000230_abnormal_systemic_arterial0.28990879
169MP0005666_abnormal_adipose_tissue0.28690816
170MP0001881_abnormal_mammary_gland0.27645742
171MP0001243_abnormal_dermal_layer0.27266668
172MP0001853_heart_inflammation0.26566195
173MP0001845_abnormal_inflammatory_respons0.26431297
174MP0004264_abnormal_extraembryonic_tissu0.25043832
175MP0005167_abnormal_blood-brain_barrier0.23598024
176MP0005164_abnormal_response_to0.23396144
177MP0009384_cardiac_valve_regurgitation0.22687735

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.45132507
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.44567199
3Intrahepatic cholestasis (HP:0001406)7.38552439
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.71485591
5Prolonged partial thromboplastin time (HP:0003645)6.63736206
6Hypobetalipoproteinemia (HP:0003563)6.42792968
7Xanthomatosis (HP:0000991)6.15815352
8Hyperlipoproteinemia (HP:0010980)5.55124349
9Complement deficiency (HP:0004431)5.48231912
10Joint hemorrhage (HP:0005261)4.84355262
11Hypolipoproteinemia (HP:0010981)4.74686614
12Hyperammonemia (HP:0001987)4.61913447
13Hyperglycinemia (HP:0002154)4.59513236
14Epidermoid cyst (HP:0200040)4.39947468
15Abnormality of the common coagulation pathway (HP:0010990)4.35368890
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.32087688
17Pancreatic cysts (HP:0001737)4.26345450
18Ketosis (HP:0001946)4.26071517
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.25980737
20Abnormality of methionine metabolism (HP:0010901)4.23863495
21Fat malabsorption (HP:0002630)4.18182997
22Congenital stationary night blindness (HP:0007642)4.17897938
23Abnormality of glutamine family amino acid metabolism (HP:0010902)4.13263786
24Hypoalphalipoproteinemia (HP:0003233)4.10521499
25Abnormality of aspartate family amino acid metabolism (HP:0010899)4.08473346
26Hyperglycinuria (HP:0003108)4.01865938
27Abnormality of serine family amino acid metabolism (HP:0010894)4.00278931
28Abnormality of glycine metabolism (HP:0010895)4.00278931
29Abnormality of complement system (HP:0005339)3.99555940
30Abnormality of pyrimidine metabolism (HP:0004353)3.93657422
31Abnormality of midbrain morphology (HP:0002418)3.89119676
32Molar tooth sign on MRI (HP:0002419)3.89119676
33Abnormality of the intrinsic pathway (HP:0010989)3.81396121
34Conjugated hyperbilirubinemia (HP:0002908)3.80394185
35Pancreatic fibrosis (HP:0100732)3.79637157
36Hypoglycemic coma (HP:0001325)3.78932584
37True hermaphroditism (HP:0010459)3.69909039
38Hypercholesterolemia (HP:0003124)3.53607322
39Nephronophthisis (HP:0000090)3.42655895
40Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.34872955
41Hyperbilirubinemia (HP:0002904)3.32248435
42Abnormality of fatty-acid metabolism (HP:0004359)3.32065954
43Abnormality of the renal cortex (HP:0011035)3.30579920
44Type II lissencephaly (HP:0007260)3.26892004
45Attenuation of retinal blood vessels (HP:0007843)3.23962005
46Steatorrhea (HP:0002570)3.22414975
47Hypochromic microcytic anemia (HP:0004840)3.21767554
48Delayed CNS myelination (HP:0002188)3.18799980
49Abnormality of nucleobase metabolism (HP:0010932)3.11866321
50Abnormality of serum amino acid levels (HP:0003112)3.11658503
51Abnormality of the renal medulla (HP:0100957)3.05272731
52Ketoacidosis (HP:0001993)3.02123182
53Myocardial infarction (HP:0001658)3.00013905
54Hepatocellular carcinoma (HP:0001402)2.92818510
55Spontaneous abortion (HP:0005268)2.92135388
56Abnormal rod and cone electroretinograms (HP:0008323)2.90530337
57Systemic lupus erythematosus (HP:0002725)2.82962897
58Metabolic acidosis (HP:0001942)2.79393246
59Abolished electroretinogram (ERG) (HP:0000550)2.76830315
60Skin nodule (HP:0200036)2.74621049
61Congenital, generalized hypertrichosis (HP:0004540)2.71273815
62Abnormality of purine metabolism (HP:0004352)2.70970770
63Medial flaring of the eyebrow (HP:0010747)2.69326298
64Vascular calcification (HP:0004934)2.69268959
65Abnormality of alanine metabolism (HP:0010916)2.63946436
66Hyperalaninemia (HP:0003348)2.63946436
67Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.63946436
68Polydipsia (HP:0001959)2.63504674
69Abnormal drinking behavior (HP:0030082)2.63504674
70Lethargy (HP:0001254)2.61223561
71Abnormality of dicarboxylic acid metabolism (HP:0010995)2.60523485
72Dicarboxylic aciduria (HP:0003215)2.60523485
73Tubular atrophy (HP:0000092)2.57373385
74Cystic liver disease (HP:0006706)2.56604589
75Mitral stenosis (HP:0001718)2.52335066
76Recurrent gram-negative bacterial infections (HP:0005420)2.50431668
77Hypoglycemic seizures (HP:0002173)2.48894538
78Pendular nystagmus (HP:0012043)2.46955506
79Abnormal gallbladder morphology (HP:0012437)2.46071663
80Spastic diplegia (HP:0001264)2.43645092
81Gout (HP:0001997)2.43621794
82Chronic hepatic failure (HP:0100626)2.42949628
83Hyperventilation (HP:0002883)2.42752868
84Stomach cancer (HP:0012126)2.41324664
85Cholelithiasis (HP:0001081)2.40852176
86Acanthocytosis (HP:0001927)2.40302173
87Neonatal onset (HP:0003623)2.37991419
88Large for gestational age (HP:0001520)2.37840240
89Cholecystitis (HP:0001082)2.37296249
90Abnormal gallbladder physiology (HP:0012438)2.37296249
91Cardiovascular calcification (HP:0011915)2.37255142
92Irritability (HP:0000737)2.36394664
93Decreased electroretinogram (ERG) amplitude (HP:0000654)2.36168292
94Inability to walk (HP:0002540)2.34827796
95Cerebral edema (HP:0002181)2.34156517
96Glomerulonephritis (HP:0000099)2.33201558
97Absent rod-and cone-mediated responses on ERG (HP:0007688)2.32097321
98Malnutrition (HP:0004395)2.31346173
99Hypothermia (HP:0002045)2.30528833
100Decreased central vision (HP:0007663)2.28888607
101Mitochondrial inheritance (HP:0001427)2.28633665
102Keratoconus (HP:0000563)2.28032248
103Increased corneal curvature (HP:0100692)2.28032248
104Acute necrotizing encephalopathy (HP:0006965)2.26187823
105Polyuria (HP:0000103)2.25597320
1063-Methylglutaconic aciduria (HP:0003535)2.24242118
107Cerebellar dysplasia (HP:0007033)2.24068376
108Furrowed tongue (HP:0000221)2.23245711
109Amyloidosis (HP:0011034)2.20481325
110Stomatitis (HP:0010280)2.18641111
111Increased CSF lactate (HP:0002490)2.18637309
112Bile duct proliferation (HP:0001408)2.18611419
113Abnormal biliary tract physiology (HP:0012439)2.18611419
114Sclerocornea (HP:0000647)2.18463042
115Esophageal varix (HP:0002040)2.16589369
116Gingival bleeding (HP:0000225)2.15536087
117Thyroiditis (HP:0100646)2.15385127
118Progressive inability to walk (HP:0002505)2.14966043
119Enlarged kidneys (HP:0000105)2.14796301
120Menorrhagia (HP:0000132)2.13897755
121Sensorimotor neuropathy (HP:0007141)2.13822123
122Dynein arm defect of respiratory motile cilia (HP:0012255)2.13244422
123Absent/shortened dynein arms (HP:0200106)2.13244422
124Opisthotonus (HP:0002179)2.12096166
125Pancreatitis (HP:0001733)2.11633795
126Brushfield spots (HP:0001088)2.11461079
127Methylmalonic acidemia (HP:0002912)2.10197030
128Late onset (HP:0003584)2.09352271
129Gaze-evoked nystagmus (HP:0000640)2.08305531
130Hyperinsulinemic hypoglycemia (HP:0000825)2.07495920
131Vomiting (HP:0002013)2.07355797
132Severe muscular hypotonia (HP:0006829)2.06631774
133Progressive macrocephaly (HP:0004481)2.05782773
134Lissencephaly (HP:0001339)2.05436027
135Thrombophlebitis (HP:0004418)2.04860387
136IgG deficiency (HP:0004315)2.03885861
137Optic disc pallor (HP:0000543)2.02107446
138Hemorrhage of the eye (HP:0011885)2.01325318
139Abnormality of the gallbladder (HP:0005264)2.00444695
140Constricted visual fields (HP:0001133)2.00330862
141Rickets (HP:0002748)1.99787920
142Gait imbalance (HP:0002141)1.99295592
143Generalized aminoaciduria (HP:0002909)1.98683353
144Acute encephalopathy (HP:0006846)1.98428313
145Hypoplasia of the pons (HP:0012110)1.98412228
146Anencephaly (HP:0002323)1.98271922
147Abnormality of the pons (HP:0007361)1.97176559
148Congenital hepatic fibrosis (HP:0002612)1.96738081
149Methylmalonic aciduria (HP:0012120)1.95954187
150Decreased circulating renin level (HP:0003351)1.94485824
151Male pseudohermaphroditism (HP:0000037)1.93808457
152Progressive cerebellar ataxia (HP:0002073)1.93571240
153Congenital primary aphakia (HP:0007707)1.92733531
154Congenital sensorineural hearing impairment (HP:0008527)1.92681755
155Bony spicule pigmentary retinopathy (HP:0007737)1.91866913
156Poikilocytosis (HP:0004447)1.91830756
157Status epilepticus (HP:0002133)1.90651732
158Hepatocellular necrosis (HP:0001404)1.88246577
159Abnormal mitochondria in muscle tissue (HP:0008316)1.88159034
160Abnormal enzyme/coenzyme activity (HP:0012379)1.87953559
161Abnormality of proline metabolism (HP:0010907)1.87897720
162Hydroxyprolinuria (HP:0003080)1.87897720
163Abnormal cartilage morphology (HP:0002763)1.87612705
164Hypophosphatemic rickets (HP:0004912)1.87364978
165Renal cortical cysts (HP:0000803)1.87100984
166Aplasia/Hypoplasia of the spleen (HP:0010451)1.87099989
167Clumsiness (HP:0002312)1.85809744
168Abnormality of iron homeostasis (HP:0011031)1.85749150
169Hepatic necrosis (HP:0002605)1.85692565
170Abnormal urine output (HP:0012590)1.84554516
171Febrile seizures (HP:0002373)1.84436065
172Alkalosis (HP:0001948)1.83617360
173Abnormality of transition element cation homeostasis (HP:0011030)1.82995879
174Aplasia/Hypoplasia of the tongue (HP:0010295)1.82501099
175Abnormality of B cell number (HP:0010975)1.82200376
176Nephrogenic diabetes insipidus (HP:0009806)1.80375524
177Elevated hepatic transaminases (HP:0002910)1.79680447
178Fair hair (HP:0002286)1.78040461
179Abnormal respiratory epithelium morphology (HP:0012253)1.77756820
180Abnormal respiratory motile cilium morphology (HP:0005938)1.77756820
181Abnormality of vitamin metabolism (HP:0100508)1.76313330
182Lipid accumulation in hepatocytes (HP:0006561)1.75509551
183Hypoproteinemia (HP:0003075)1.75034524
184Intestinal atresia (HP:0011100)1.74515209
185Hypoplasia of the fovea (HP:0007750)1.73359701
186Aplasia/Hypoplasia of the fovea (HP:0008060)1.73359701
187Hypoalbuminemia (HP:0003073)1.73113051
188Abnormal albumin level (HP:0012116)1.73113051
189Hypomagnesemia (HP:0002917)1.72665084
190Postaxial foot polydactyly (HP:0001830)1.72585975
191Asplenia (HP:0001746)1.71077079
192Broad-based gait (HP:0002136)1.69913920
193Hyperglycemia (HP:0003074)1.69436193
194Abnormality of renal excretion (HP:0011036)1.67903361
195Acute hepatic failure (HP:0006554)1.67890246
196Pachygyria (HP:0001302)1.67754971
197Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.67551799

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.98736234
2SIK14.91033126
3ERN14.68669147
4FGFR44.60977392
5ADRBK23.63189686
6TAOK33.28988527
7MAP4K22.99613701
8TXK2.89700547
9INSRR2.85546431
10ERBB42.82363527
11ACVR1B2.69618771
12NUAK12.55172224
13TLK12.51591610
14ZAK2.47699408
15MAP2K42.47642915
16WNK42.44464602
17BMPR1B2.42377186
18WNK32.27485210
19MST1R1.90066202
20MAPK111.88501653
21PKN21.88452259
22FLT31.80708575
23LATS11.74527978
24PIK3CG1.73507652
25TYK21.63663187
26OXSR11.60932334
27MAPK131.49222910
28TNIK1.43983193
29TRIB31.43430808
30ABL21.43152177
31DAPK21.42883953
32STK391.41616674
33NEK91.32524389
34CASK1.31778917
35PTK61.29174203
36CAMKK21.27753182
37PINK11.24900202
38MAP3K41.23816039
39FGFR21.23205276
40KDR1.20937802
41MAP3K71.19449720
42GRK61.15722269
43JAK21.13890928
44STK38L1.13826765
45FRK1.12976136
46PRKAA21.12180857
47IKBKB1.10020198
48MAP3K141.09162211
49TBK11.06093741
50MAP2K31.03313025
51MST41.00520582
52ADRBK11.00167796
53ERBB20.98612730
54JAK10.97246226
55MAPK40.96786228
56MAP3K100.96145718
57MUSK0.95856762
58PAK30.94851976
59DYRK20.94253699
60PRKCE0.92889284
61PRKCZ0.91994023
62VRK10.91861660
63NLK0.91391111
64MAPK120.91224422
65MAPK150.90375935
66PNCK0.89263909
67STK160.89113100
68TGFBR10.84933342
69TIE10.84351328
70PHKG10.84271347
71PHKG20.84271347
72CSK0.82339537
73ITK0.80244861
74IRAK30.79420751
75MAP3K110.78393627
76PIK3CA0.78189287
77MAP2K60.77340091
78TEC0.76821357
79GRK70.75453119
80SYK0.74501152
81PRKACG0.74482066
82CDK60.73959347
83MAP2K70.73494503
84MAPK70.72454755
85PLK20.72187897
86MAPKAPK30.71565326
87ERBB30.69086914
88EPHA40.68982227
89PRKAA10.68888989
90DYRK1B0.68850353
91TGFBR20.67901231
92CAMK2G0.67834579
93MET0.67773995
94TAOK20.67594326
95TRIM280.66722832
96CAMK1D0.66708920
97EPHB10.66425076
98MAP3K30.66148175
99EPHA30.66030245
100MKNK20.64495648
101CHUK0.64314800
102SGK30.64069774
103GSK3A0.62787350
104CSF1R0.62421398
105GRK10.58858351
106RPS6KA50.57538327
107CAMK2A0.56751402
108IKBKE0.56682083
109CAMK10.56041661
110VRK20.54973359
111MAPKAPK50.54169887
112MAP2K20.53373913
113MAP4K10.53134094
114AKT30.52916095
115ICK0.52875359
116PTK20.51937981
117FGFR30.51511096
118MAP3K60.50805644
119SGK20.50601753
120TNK20.50494901
121SIK30.50388870
122PTK2B0.49624793
123LYN0.49108542
124MATK0.48578174
125LATS20.48349275
126PRKCQ0.48063303
127PRKACA0.47124582
128PDPK10.46535785
129CAMK40.45654575
130NTRK30.45057422
131CSNK1G10.44124606
132MAP3K50.43923685
133LCK0.43781709
134SIK20.43498008
135NTRK20.43449996
136PRKCG0.42713001
137CSNK1A10.42614888
138CDK40.40831554
139CDK190.40445883
140IGF1R0.39750120
141MAP3K130.38165904
142BCR0.38067554
143RIPK10.37716890
144PKN10.37116600
145STK110.36283670
146MARK10.35468687
147DYRK1A0.34910809
148CDK30.34197642
149EGFR0.33527462
150TRPM70.33367815
151STK30.32921800
152MAP2K10.32691931
153CSNK1A1L0.32173075
154PRKCI0.31746940
155MTOR0.30974739
156IRAK20.30402305
157SGK2230.30213403
158SGK4940.30213403
159RET0.27895703
160PDK10.27767639
161PRKCA0.25652224
162CSNK1G20.24413977
163IRAK10.23386221
164CSNK1G30.21061420
165KIT0.20847466
166ABL10.20571745
167MAPK30.18349546
168BLK0.18027631
169BMX0.17498723

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.61324084
2Nitrogen metabolism_Homo sapiens_hsa009103.40583146
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.38599993
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.33921321
5Arginine biosynthesis_Homo sapiens_hsa002203.07611571
6Complement and coagulation cascades_Homo sapiens_hsa046102.77975402
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.67652240
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.65459193
9* Tryptophan metabolism_Homo sapiens_hsa003802.62301668
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.54885642
11Fatty acid degradation_Homo sapiens_hsa000712.46025845
12Oxidative phosphorylation_Homo sapiens_hsa001902.43676532
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.40815347
14Phototransduction_Homo sapiens_hsa047442.40069475
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.30582346
16Butanoate metabolism_Homo sapiens_hsa006502.16074594
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.16063546
18Peroxisome_Homo sapiens_hsa041462.09978444
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.02323942
20Intestinal immune network for IgA production_Homo sapiens_hsa046722.01469868
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.99378455
22Chemical carcinogenesis_Homo sapiens_hsa052041.98998078
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.96793032
24Histidine metabolism_Homo sapiens_hsa003401.91961084
25Propanoate metabolism_Homo sapiens_hsa006401.91230213
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.85212347
27PPAR signaling pathway_Homo sapiens_hsa033201.84499121
28Protein export_Homo sapiens_hsa030601.81366450
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.79833680
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.79192524
31Fatty acid metabolism_Homo sapiens_hsa012121.78983060
32Staphylococcus aureus infection_Homo sapiens_hsa051501.77067380
33Retinol metabolism_Homo sapiens_hsa008301.74669851
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.74386204
35Caffeine metabolism_Homo sapiens_hsa002321.73020753
36Parkinsons disease_Homo sapiens_hsa050121.72415375
37beta-Alanine metabolism_Homo sapiens_hsa004101.71155624
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.70267716
39Type I diabetes mellitus_Homo sapiens_hsa049401.63121606
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.60898053
41Asthma_Homo sapiens_hsa053101.58721384
42Selenocompound metabolism_Homo sapiens_hsa004501.55696399
43Phenylalanine metabolism_Homo sapiens_hsa003601.54861607
44Graft-versus-host disease_Homo sapiens_hsa053321.54211850
45Allograft rejection_Homo sapiens_hsa053301.53846511
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.51958665
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.49542389
48Bile secretion_Homo sapiens_hsa049761.49504530
49Primary immunodeficiency_Homo sapiens_hsa053401.49447041
50Nicotine addiction_Homo sapiens_hsa050331.48820606
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.48602546
52Tyrosine metabolism_Homo sapiens_hsa003501.45111141
53Autoimmune thyroid disease_Homo sapiens_hsa053201.44024305
54Pyruvate metabolism_Homo sapiens_hsa006201.35990066
55Sulfur metabolism_Homo sapiens_hsa009201.34210233
56Fatty acid elongation_Homo sapiens_hsa000621.30013423
57Cysteine and methionine metabolism_Homo sapiens_hsa002701.29515160
58Starch and sucrose metabolism_Homo sapiens_hsa005001.28309544
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.26512611
60RNA polymerase_Homo sapiens_hsa030201.25944504
61Homologous recombination_Homo sapiens_hsa034401.25763653
62Folate biosynthesis_Homo sapiens_hsa007901.23534908
63Basal transcription factors_Homo sapiens_hsa030221.21167352
64Biosynthesis of amino acids_Homo sapiens_hsa012301.20034320
65ABC transporters_Homo sapiens_hsa020101.19722742
66Steroid biosynthesis_Homo sapiens_hsa001001.18070395
67Fat digestion and absorption_Homo sapiens_hsa049751.11442359
68Carbon metabolism_Homo sapiens_hsa012001.10994520
69Alzheimers disease_Homo sapiens_hsa050101.09243976
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.07428395
71Rheumatoid arthritis_Homo sapiens_hsa053231.05065830
72Olfactory transduction_Homo sapiens_hsa047401.04237895
73Vitamin B6 metabolism_Homo sapiens_hsa007501.03947640
74Maturity onset diabetes of the young_Homo sapiens_hsa049501.02665569
75Cyanoamino acid metabolism_Homo sapiens_hsa004601.02649518
76Morphine addiction_Homo sapiens_hsa050321.02584951
77Taste transduction_Homo sapiens_hsa047421.02440963
78Huntingtons disease_Homo sapiens_hsa050161.01816496
79Cardiac muscle contraction_Homo sapiens_hsa042600.98779993
80Arginine and proline metabolism_Homo sapiens_hsa003300.97313413
81Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.96467538
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.95962170
83Sulfur relay system_Homo sapiens_hsa041220.95349440
84Collecting duct acid secretion_Homo sapiens_hsa049660.94010674
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91185877
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90395523
87Fanconi anemia pathway_Homo sapiens_hsa034600.88652556
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.87999084
89Lysine degradation_Homo sapiens_hsa003100.83424650
90Vitamin digestion and absorption_Homo sapiens_hsa049770.83232987
91Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81760136
92One carbon pool by folate_Homo sapiens_hsa006700.79984506
93Proteasome_Homo sapiens_hsa030500.77985020
94Insulin secretion_Homo sapiens_hsa049110.77393031
95Serotonergic synapse_Homo sapiens_hsa047260.75387088
96RNA degradation_Homo sapiens_hsa030180.73853919
97Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69902327
98Antigen processing and presentation_Homo sapiens_hsa046120.69249928
99GABAergic synapse_Homo sapiens_hsa047270.68025753
100Glycerolipid metabolism_Homo sapiens_hsa005610.68010477
101Glutathione metabolism_Homo sapiens_hsa004800.63799309
102NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62843608
103Glutamatergic synapse_Homo sapiens_hsa047240.59393482
104Mineral absorption_Homo sapiens_hsa049780.56701902
105Salivary secretion_Homo sapiens_hsa049700.55533092
106Fatty acid biosynthesis_Homo sapiens_hsa000610.55126183
107Circadian entrainment_Homo sapiens_hsa047130.54611819
108Pentose phosphate pathway_Homo sapiens_hsa000300.53952964
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52428814
110Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49976877
111Hematopoietic cell lineage_Homo sapiens_hsa046400.49391934
112Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.47472440
113Purine metabolism_Homo sapiens_hsa002300.47238531
114SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47061908
115NF-kappa B signaling pathway_Homo sapiens_hsa040640.45739472
116* Metabolic pathways_Homo sapiens_hsa011000.45737461
117Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44218533
118Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.42333915
119Prion diseases_Homo sapiens_hsa050200.38863287
120Calcium signaling pathway_Homo sapiens_hsa040200.38843024
121Circadian rhythm_Homo sapiens_hsa047100.33634879
122Vascular smooth muscle contraction_Homo sapiens_hsa042700.29531213
123Fructose and mannose metabolism_Homo sapiens_hsa000510.26673887
124Galactose metabolism_Homo sapiens_hsa000520.26555824
125alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26502436
126Linoleic acid metabolism_Homo sapiens_hsa005910.23670071
127Insulin resistance_Homo sapiens_hsa049310.20724439
128Adipocytokine signaling pathway_Homo sapiens_hsa049200.19120564
129Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.16685247
130Glycerophospholipid metabolism_Homo sapiens_hsa005640.15125730
131Glucagon signaling pathway_Homo sapiens_hsa049220.08110584
132Ether lipid metabolism_Homo sapiens_hsa00565-0.2457259
133Amoebiasis_Homo sapiens_hsa05146-0.2452372
134Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.2430472
135Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2416043
136Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2412964
137RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.2202087
138Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2171520
139Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2131745
140Renin-angiotensin system_Homo sapiens_hsa04614-0.2059215
141Hepatitis C_Homo sapiens_hsa05160-0.1782146
142Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1673441
143Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1606567
144Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1508681
145Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1431359
146Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1375637
147Insulin signaling pathway_Homo sapiens_hsa04910-0.1253038
148Regulation of autophagy_Homo sapiens_hsa04140-0.1216935
149Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0726971
150Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0594908
151Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0578122
152Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0412364
153AMPK signaling pathway_Homo sapiens_hsa04152-0.0014843

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