IDSP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of growth hormone secretion (GO:0060124)9.85422432
2growth hormone secretion (GO:0030252)8.14013415
3regulation of growth hormone secretion (GO:0060123)6.62753738
4positive regulation of oligodendrocyte differentiation (GO:0048714)5.39248720
5dentate gyrus development (GO:0021542)5.34744188
6substrate-independent telencephalic tangential interneuron migration (GO:0021843)5.34062342
7substrate-independent telencephalic tangential migration (GO:0021826)5.34062342
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.17634733
9epithelial cilium movement (GO:0003351)4.94548999
10behavioral response to nicotine (GO:0035095)4.77398480
11regulation of circadian sleep/wake cycle (GO:0042749)4.68221142
12regulation of circadian sleep/wake cycle, sleep (GO:0045187)4.68221142
13positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)4.59244159
14segment specification (GO:0007379)4.56264193
15axonemal dynein complex assembly (GO:0070286)4.40162188
16cilium movement (GO:0003341)4.26945974
17positive regulation of circadian rhythm (GO:0042753)4.23164506
18regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)4.22541422
19secondary heart field specification (GO:0003139)4.05928386
20heart field specification (GO:0003128)4.05928386
21urate metabolic process (GO:0046415)3.99030956
22circadian sleep/wake cycle process (GO:0022410)3.92277570
23cilium or flagellum-dependent cell motility (GO:0001539)3.92264228
24negative regulation of telomere maintenance (GO:0032205)3.89729356
25Arp2/3 complex-mediated actin nucleation (GO:0034314)3.73506007
26CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.71722698
27T-helper cell differentiation (GO:0042093)3.71722698
28regulation of germinal center formation (GO:0002634)3.70468658
29T cell differentiation involved in immune response (GO:0002292)3.68469130
30alpha-beta T cell differentiation involved in immune response (GO:0002293)3.68469130
31alpha-beta T cell activation involved in immune response (GO:0002287)3.68469130
32positive regulation of defense response to virus by host (GO:0002230)3.56101375
33forebrain morphogenesis (GO:0048853)3.53254063
34cardiac chamber formation (GO:0003207)3.41923414
35cytokine biosynthetic process (GO:0042089)3.41031572
36actin nucleation (GO:0045010)3.38667439
37regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.36967896
38positive regulation of protein homodimerization activity (GO:0090073)3.36779579
39cardiac ventricle formation (GO:0003211)3.32022868
40ADP metabolic process (GO:0046031)3.27228394
41thalamus development (GO:0021794)3.24942028
42ubiquinone biosynthetic process (GO:0006744)3.23416809
43axoneme assembly (GO:0035082)3.23133764
44protein polyglutamylation (GO:0018095)3.22092113
45regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.20761666
46parturition (GO:0007567)3.19270675
47positive regulation of cell fate commitment (GO:0010455)3.17072719
48positive regulation of granulocyte differentiation (GO:0030854)3.15277419
49circadian behavior (GO:0048512)3.11178080
50embryonic viscerocranium morphogenesis (GO:0048703)3.09231546
51glycerophospholipid catabolic process (GO:0046475)3.03018898
52regulation of isotype switching to IgG isotypes (GO:0048302)3.02840001
53regulation of T cell mediated cytotoxicity (GO:0001914)3.02536116
54motile cilium assembly (GO:0044458)3.01637480
55response to food (GO:0032094)3.00429961
56regulation of sarcomere organization (GO:0060297)2.99757474
57regulation of memory T cell differentiation (GO:0043380)2.94294320
58regulation of autophagic vacuole assembly (GO:2000785)2.94068346
59rhythmic behavior (GO:0007622)2.93417441
60positive regulation of translational initiation (GO:0045948)2.89139420
61regulation of activation of Janus kinase activity (GO:0010533)2.88052925
62cytidine metabolic process (GO:0046087)2.85812816
63cytidine catabolic process (GO:0006216)2.85812816
64cytidine deamination (GO:0009972)2.85812816
65cranial nerve morphogenesis (GO:0021602)2.85674413
66phenylpropanoid metabolic process (GO:0009698)2.83692047
67positive regulation of T cell mediated cytotoxicity (GO:0001916)2.83483267
68positive regulation of activated T cell proliferation (GO:0042104)2.83247405
69activation of MAPKKK activity (GO:0000185)2.82855516
70phosphatidylserine acyl-chain remodeling (GO:0036150)2.79596727
71positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.78389520
72positive regulation of glial cell differentiation (GO:0045687)2.78319769
73synaptic transmission, cholinergic (GO:0007271)2.77855651
74regulation of collateral sprouting (GO:0048670)2.77814078
75ubiquinone metabolic process (GO:0006743)2.76163673
76regulation of vacuole organization (GO:0044088)2.76095610
77cytokine metabolic process (GO:0042107)2.76000474
78AMP metabolic process (GO:0046033)2.73880947
79quinone biosynthetic process (GO:1901663)2.72318547
80interferon-gamma production (GO:0032609)2.71616985
81mast cell activation involved in immune response (GO:0002279)2.71241698
82mast cell degranulation (GO:0043303)2.71241698
83detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.70831113
84detection of temperature stimulus involved in sensory perception (GO:0050961)2.70831113
85tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.67259987
86RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.67259987
87face development (GO:0060324)2.65673464
88positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.64178633
89negative regulation of T-helper cell differentiation (GO:0045623)2.63426051
90negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.63426051
91specification of organ identity (GO:0010092)2.63395388
92indole-containing compound catabolic process (GO:0042436)2.60066200
93indolalkylamine catabolic process (GO:0046218)2.60066200
94tryptophan catabolic process (GO:0006569)2.60066200
95negative regulation of membrane potential (GO:0045837)2.59763746
96regulation of dopamine secretion (GO:0014059)2.59401358
97mitochondrion distribution (GO:0048311)2.56951230
98positive regulation of cardiac muscle cell differentiation (GO:2000727)2.55539615
99regulation of granulocyte differentiation (GO:0030852)2.55351657
100regulation of chronic inflammatory response (GO:0002676)2.55276444

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.55615519
2ZNF274_21170338_ChIP-Seq_K562_Hela3.84272116
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.56848226
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.18766060
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.97289822
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.82284774
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.66761823
8CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.64536003
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.60218539
10GBX2_23144817_ChIP-Seq_PC3_Human2.47534602
11IGF1R_20145208_ChIP-Seq_DFB_Human2.45989090
12NOTCH1_21737748_ChIP-Seq_TLL_Human2.39401223
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.36447648
14LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.84285260
15ER_23166858_ChIP-Seq_MCF-7_Human1.83228219
16EZH2_22144423_ChIP-Seq_EOC_Human1.80281207
17VDR_22108803_ChIP-Seq_LS180_Human1.73267351
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.69284926
19GATA3_26560356_Chip-Seq_TH2_Human1.67866650
20CBX2_27304074_Chip-Seq_ESCs_Mouse1.65149667
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.60387322
22ELK4_26923725_Chip-Seq_MESODERM_Mouse1.59718309
23BCAT_22108803_ChIP-Seq_LS180_Human1.59056388
24JARID2_20064375_ChIP-Seq_MESCs_Mouse1.55905550
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51548163
26EED_16625203_ChIP-ChIP_MESCs_Mouse1.48842047
27BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.47309383
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.43620574
29EZH2_27304074_Chip-Seq_ESCs_Mouse1.42708227
30PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.41941297
31DROSHA_22980978_ChIP-Seq_HELA_Human1.41652873
32GATA3_21878914_ChIP-Seq_MCF-7_Human1.39894674
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.39523408
34NANOG_20526341_ChIP-Seq_ESCs_Human1.38572832
35EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.36483245
36TP53_22573176_ChIP-Seq_HFKS_Human1.35676307
37RUNX_20019798_ChIP-Seq_JUKART_Human1.35048825
38MYB_26560356_Chip-Seq_TH2_Human1.34487232
39PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.32095122
40JARID2_20075857_ChIP-Seq_MESCs_Mouse1.31460365
41POU5F1_16153702_ChIP-ChIP_HESCs_Human1.31170916
42TCF4_22108803_ChIP-Seq_LS180_Human1.29279466
43TAF2_19829295_ChIP-Seq_ESCs_Human1.29132335
44RNF2_27304074_Chip-Seq_NSC_Mouse1.28315843
45MYC_19829295_ChIP-Seq_ESCs_Human1.27998851
46NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.27515991
47IKZF1_21737484_ChIP-ChIP_HCT116_Human1.26402926
48KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25402924
49EZH2_27294783_Chip-Seq_ESCs_Mouse1.23960964
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.23938942
51SUZ12_27294783_Chip-Seq_ESCs_Mouse1.23725345
52RXR_22108803_ChIP-Seq_LS180_Human1.22602146
53NCOR_22424771_ChIP-Seq_293T_Human1.22562734
54CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.22013598
55PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.21317291
56AR_21572438_ChIP-Seq_LNCaP_Human1.20238685
57CDX2_22108803_ChIP-Seq_LS180_Human1.20176471
58RUNX2_22187159_ChIP-Seq_PCA_Human1.19186432
59TP53_20018659_ChIP-ChIP_R1E_Mouse1.18307693
60SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.18048673
61P300_19829295_ChIP-Seq_ESCs_Human1.17945069
62SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.16959140
63FLI1_27457419_Chip-Seq_LIVER_Mouse1.15700691
64GATA3_27048872_Chip-Seq_THYMUS_Human1.15273961
65PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.13657275
66SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.12100175
67SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.11695785
68ZFP57_27257070_Chip-Seq_ESCs_Mouse1.11366086
69VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.10225469
70CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.09906964
71ETV2_25802403_ChIP-Seq_MESCs_Mouse1.09702779
72GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07002776
73RAC3_21632823_ChIP-Seq_H3396_Human1.06531547
74ESR1_15608294_ChIP-ChIP_MCF-7_Human1.05501665
75GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.04893159
76FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03921934
77SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.02540727
78RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.02438453
79RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.01294467
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00547314
81TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00547314
82RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00373922
83UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99818898
84EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.99496721
85TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99471236
86CEBPB_22108803_ChIP-Seq_LS180_Human0.99399155
87ERA_21632823_ChIP-Seq_H3396_Human0.98065581
88GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97804250
89AR_20517297_ChIP-Seq_VCAP_Human0.97542320
90FOXA1_25329375_ChIP-Seq_VCAP_Human0.96453536
91FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96453536
92LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.95659590
93REST_21632747_ChIP-Seq_MESCs_Mouse0.95413507
94MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.95226201
95SMAD4_21799915_ChIP-Seq_A2780_Human0.94751737
96E2F1_20622854_ChIP-Seq_HELA_Human0.94452973
97RNF2_18974828_ChIP-Seq_MESCs_Mouse0.93545409
98EZH2_18974828_ChIP-Seq_MESCs_Mouse0.93545409
99SCL_19346495_ChIP-Seq_HPC-7_Human0.93249170
100NANOG_19829295_ChIP-Seq_ESCs_Human0.93238213

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology4.09748648
2MP0002653_abnormal_ependyma_morphology3.44773485
3MP0002837_dystrophic_cardiac_calcinosis3.27142353
4MP0003787_abnormal_imprinting2.98455670
5MP0002009_preneoplasia2.95334524
6MP0009333_abnormal_splenocyte_physiolog2.95253232
7MP0001502_abnormal_circadian_rhythm2.89362661
8MP0005379_endocrine/exocrine_gland_phen2.73929283
9MP0003763_abnormal_thymus_physiology2.73260794
10MP0002163_abnormal_gland_morphology2.54532638
11MP0005671_abnormal_response_to2.38226899
12MP0001348_abnormal_lacrimal_gland2.31524721
13MP0003806_abnormal_nucleotide_metabolis2.18036659
14MP0002160_abnormal_reproductive_system2.11187301
15MP0002822_catalepsy1.92157217
16MP0000015_abnormal_ear_pigmentation1.88880516
17MP0001501_abnormal_sleep_pattern1.88863000
18MP0001835_abnormal_antigen_presentation1.80913221
19MP0001984_abnormal_olfaction1.75035216
20MP0004381_abnormal_hair_follicle1.69279579
21MP0004142_abnormal_muscle_tone1.68957281
22MP0004084_abnormal_cardiac_muscle1.62296795
23MP0005389_reproductive_system_phenotype1.62041233
24MP0004742_abnormal_vestibular_system1.59025057
25MP0005000_abnormal_immune_tolerance1.56582148
26MP0005167_abnormal_blood-brain_barrier1.54469500
27MP0001188_hyperpigmentation1.54376088
28MP0001764_abnormal_homeostasis1.51776047
29MP0002166_altered_tumor_susceptibility1.49821698
30MP0008789_abnormal_olfactory_epithelium1.47748143
31MP0001800_abnormal_humoral_immune1.47140057
32MP0001905_abnormal_dopamine_level1.46641475
33MP0001873_stomach_inflammation1.44895091
34MP0001270_distended_abdomen1.44712937
35MP0001968_abnormal_touch/_nociception1.41218195
36MP0000778_abnormal_nervous_system1.36226603
37MP0005387_immune_system_phenotype1.31584179
38MP0001790_abnormal_immune_system1.31584179
39MP0002405_respiratory_system_inflammati1.29039517
40MP0002723_abnormal_immune_serum1.28536556
41MP0005551_abnormal_eye_electrophysiolog1.26608369
42MP0005174_abnormal_tail_pigmentation1.25552849
43MP0005535_abnormal_body_temperature1.24961340
44MP0006082_CNS_inflammation1.21896638
45MP0000371_diluted_coat_color1.21739931
46MP0003195_calcinosis1.21735967
47MP0002249_abnormal_larynx_morphology1.20780302
48MP0000681_abnormal_thyroid_gland1.18279721
49MP0005499_abnormal_olfactory_system1.16335124
50MP0005394_taste/olfaction_phenotype1.16335124
51MP0010386_abnormal_urinary_bladder1.13156385
52MP0001986_abnormal_taste_sensitivity1.10439812
53MP0003011_delayed_dark_adaptation1.09929916
54MP0000678_abnormal_parathyroid_gland1.09889584
55MP0005377_hearing/vestibular/ear_phenot1.08947750
56MP0003878_abnormal_ear_physiology1.08947750
57MP0005025_abnormal_response_to1.07588047
58MP0003866_abnormal_defecation1.07472074
59MP0002420_abnormal_adaptive_immunity1.05498768
60MP0001819_abnormal_immune_cell1.05478137
61MP0001485_abnormal_pinna_reflex1.04847002
62MP0000490_abnormal_crypts_of1.04234895
63MP0005253_abnormal_eye_physiology1.03733550
64MP0005448_abnormal_energy_balance0.98743464
65MP0002148_abnormal_hypersensitivity_rea0.98517653
66MP0006072_abnormal_retinal_apoptosis0.97817709
67MP0002693_abnormal_pancreas_physiology0.97647657
68MP0001486_abnormal_startle_reflex0.97144419
69MP0003172_abnormal_lysosome_physiology0.97139014
70MP0003123_paternal_imprinting0.97031919
71MP0002933_joint_inflammation0.96879497
72MP0002557_abnormal_social/conspecific_i0.96876114
73MP0001919_abnormal_reproductive_system0.96583529
74MP0009745_abnormal_behavioral_response0.95764261
75MP0006276_abnormal_autonomic_nervous0.95388862
76MP0009785_altered_susceptibility_to0.95086998
77MP0008875_abnormal_xenobiotic_pharmacok0.94329355
78MP0010155_abnormal_intestine_physiology0.93481290
79MP0000230_abnormal_systemic_arterial0.93164127
80MP0009046_muscle_twitch0.91873519
81MP0002452_abnormal_antigen_presenting0.89990938
82MP0002229_neurodegeneration0.88622178
83MP0002006_tumorigenesis0.88607984
84MP0008872_abnormal_physiological_respon0.88142873
85MP0004885_abnormal_endolymph0.85117266
86MP0002572_abnormal_emotion/affect_behav0.85093114
87MP0002272_abnormal_nervous_system0.84363120
88MP0002095_abnormal_skin_pigmentation0.83656922
89MP0003136_yellow_coat_color0.79631285
90MP0001529_abnormal_vocalization0.78918087
91MP0008007_abnormal_cellular_replicative0.78295795
92MP0003724_increased_susceptibility_to0.76720229
93MP0002638_abnormal_pupillary_reflex0.76389307
94MP0006292_abnormal_olfactory_placode0.75898505
95MP0000372_irregular_coat_pigmentation0.74852317
96MP0000639_abnormal_adrenal_gland0.73850411
97MP0001849_ear_inflammation0.71889275
98MP0002177_abnormal_outer_ear0.68776272
99MP0005075_abnormal_melanosome_morpholog0.68330609
100MP0001663_abnormal_digestive_system0.66734450

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)6.12685440
2Absent/shortened dynein arms (HP:0200106)6.12685440
3Absent rod-and cone-mediated responses on ERG (HP:0007688)5.33456986
4Abnormal ciliary motility (HP:0012262)5.22304886
5Abnormal respiratory motile cilium morphology (HP:0005938)4.82285482
6Abnormal respiratory epithelium morphology (HP:0012253)4.82285482
7Abnormal rod and cone electroretinograms (HP:0008323)4.58720733
8Abnormal respiratory motile cilium physiology (HP:0012261)4.28316713
9Metaphyseal dysplasia (HP:0100255)3.87862722
10Pancreatic cysts (HP:0001737)3.61557264
11Pancreatic fibrosis (HP:0100732)3.55010390
12Abnormality of DNA repair (HP:0003254)3.42103656
13Neoplasm of the adrenal cortex (HP:0100641)3.40972165
14Chronic sinusitis (HP:0011109)3.28342678
15Reduced antithrombin III activity (HP:0001976)3.11119695
16True hermaphroditism (HP:0010459)3.10592848
17Hepatoblastoma (HP:0002884)3.04427332
18Abolished electroretinogram (ERG) (HP:0000550)2.95439512
19Pendular nystagmus (HP:0012043)2.92653619
20Poikiloderma (HP:0001029)2.90106176
21Abnormality of midbrain morphology (HP:0002418)2.87845507
22Molar tooth sign on MRI (HP:0002419)2.87845507
23Chorioretinal atrophy (HP:0000533)2.85353020
24Type I transferrin isoform profile (HP:0003642)2.83547072
25Pustule (HP:0200039)2.73239196
26Congenital stationary night blindness (HP:0007642)2.70486527
27Cystic liver disease (HP:0006706)2.54197809
28Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.51404397
29Abnormal biliary tract physiology (HP:0012439)2.50152407
30Bile duct proliferation (HP:0001408)2.50152407
31Abnormality of the renal cortex (HP:0011035)2.47347322
32Bronchiectasis (HP:0002110)2.46544955
33Occipital encephalocele (HP:0002085)2.42295775
34Severe visual impairment (HP:0001141)2.42157457
35Supernumerary spleens (HP:0009799)2.38534493
36Hypoglycemic seizures (HP:0002173)2.37182716
37J-shaped sella turcica (HP:0002680)2.36262252
38Rhinitis (HP:0012384)2.35984088
39Adrenal hypoplasia (HP:0000835)2.34745607
40Hypothermia (HP:0002045)2.27146457
41Type II lissencephaly (HP:0007260)2.25820312
42Absent thumb (HP:0009777)2.21066244
43Medial flaring of the eyebrow (HP:0010747)2.20513701
44Congenital hepatic fibrosis (HP:0002612)2.18420121
45Optic neuritis (HP:0100653)2.18275825
46Retrobulbar optic neuritis (HP:0100654)2.18275825
47Severe combined immunodeficiency (HP:0004430)2.17700738
48Muscle fiber atrophy (HP:0100295)2.11963090
49Nephronophthisis (HP:0000090)2.10087766
50Cerebral palsy (HP:0100021)2.10018287
51Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.09475521
52Abnormal glycosylation (HP:0012345)2.09102798
53Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.09102798
54Abnormal protein N-linked glycosylation (HP:0012347)2.09102798
55Abnormal protein glycosylation (HP:0012346)2.09102798
56Type 2 muscle fiber atrophy (HP:0003554)2.07554292
57Abnormality of the preputium (HP:0100587)2.06020953
58IgG deficiency (HP:0004315)2.03807180
59Epidermoid cyst (HP:0200040)2.03065413
60Adactyly (HP:0009776)2.02607971
61Recurrent sinusitis (HP:0011108)2.00891697
62Myositis (HP:0100614)1.98433607
63Thyroiditis (HP:0100646)1.97530363
64Decreased central vision (HP:0007663)1.97143121
65Hypoplasia of the thymus (HP:0000778)1.95845954
66Abnormality of the intrinsic pathway (HP:0010989)1.94678301
67Stomatitis (HP:0010280)1.92879791
68Abnormal drinking behavior (HP:0030082)1.91147558
69Polydipsia (HP:0001959)1.91147558
70Elevated erythrocyte sedimentation rate (HP:0003565)1.90961044
71Cerebellar dysplasia (HP:0007033)1.89100241
72Abnormality of the renal medulla (HP:0100957)1.88316324
73Male pseudohermaphroditism (HP:0000037)1.85777782
74Increased muscle lipid content (HP:0009058)1.80558144
75Aplasia/Hypoplasia of the uvula (HP:0010293)1.80133039
76Keratoconjunctivitis sicca (HP:0001097)1.79183977
77Increased intramyocellular lipid droplets (HP:0012240)1.79097987
78Keratoconjunctivitis (HP:0001096)1.78831870
79Poor coordination (HP:0002370)1.78435823
80Gait imbalance (HP:0002141)1.76899203
81Gastrointestinal inflammation (HP:0004386)1.76661025
82Enlarged kidneys (HP:0000105)1.76171866
83Abnormal pancreas size (HP:0012094)1.75480750
84Polyuria (HP:0000103)1.75173531
85Attenuation of retinal blood vessels (HP:0007843)1.75153920
86Congenital primary aphakia (HP:0007707)1.75013668
87Abnormality of the renal collecting system (HP:0004742)1.74684209
88Cervical subluxation (HP:0003308)1.73639777
89Nephrogenic diabetes insipidus (HP:0009806)1.70710465
90Asplenia (HP:0001746)1.70601087
91Postaxial foot polydactyly (HP:0001830)1.70117227
92Orchitis (HP:0100796)1.69005429
93Increased corneal curvature (HP:0100692)1.68970569
94Keratoconus (HP:0000563)1.68970569
95Abnormality of fatty-acid metabolism (HP:0004359)1.67522126
96Renal cortical cysts (HP:0000803)1.66928613
97Abnormality of pyrimidine metabolism (HP:0004353)1.66729701
98Neoplasm of the adrenal gland (HP:0100631)1.66458189
99Rhabdomyolysis (HP:0003201)1.65027978
100Recurrent cutaneous fungal infections (HP:0011370)1.63424583

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK3.41463333
2PINK12.63305899
3ADRBK22.59352372
4KDR2.50181383
5GRK62.43494402
6MAP2K72.35685282
7CAMKK22.22053694
8LATS12.18706639
9EPHA42.13543825
10INSRR2.08270140
11CDK191.87701995
12STK38L1.87076486
13CDK31.86590252
14SYK1.81830250
15FES1.80471760
16TNK21.79269804
17FRK1.71598558
18MAP3K131.71576090
19MARK31.71504792
20GRK11.70045778
21MAP4K21.60202950
22MAP2K61.59286754
23MUSK1.56816414
24TLK11.54577636
25ITK1.52452785
26MATK1.46270951
27IKBKE1.43474253
28STK161.36653434
29PRKCQ1.36101150
30TAOK31.32118007
31GRK71.27957314
32MAP4K11.25356784
33MAPK121.22126389
34CAMK1D1.21665408
35TESK21.21275500
36MAPK71.20195403
37MST41.15200092
38EPHA31.14691832
39MAPK151.11854315
40IRAK11.09410137
41STK241.08897570
42CSF1R1.08568994
43NLK1.06912712
44TYRO31.03716703
45BTK1.01385271
46HCK0.97753807
47PTK2B0.90408404
48OBSCN0.90271987
49CSK0.88295045
50MAPK130.87571480
51CSNK1G30.86818024
52IKBKB0.86104490
53MAP3K70.85727835
54VRK10.85285974
55LIMK10.83019105
56LCK0.82271853
57CSNK1G20.81196989
58FER0.79423814
59NUAK10.79348110
60ZAK0.79220890
61STK30.77371402
62CAMK1G0.77242191
63SIK30.75906875
64WNK40.75744803
65CAMK10.74528912
66MAP3K110.74070269
67LYN0.73879795
68TIE10.71520236
69STK110.70580215
70NME10.70023972
71ZAP700.69888126
72PIK3CA0.67578944
73MYLK0.66287578
74TRIM280.64154882
75ERBB30.64051990
76NEK20.62975362
77CAMKK10.62437876
78PASK0.61873523
79PRKCE0.61860759
80CAMK40.61286799
81RPS6KB10.61140557
82MAP2K20.60929291
83IGF1R0.58885260
84BCKDK0.58375725
85NTRK20.56130587
86CSNK1G10.55960497
87KIT0.55770921
88ACVR1B0.55565723
89PAK30.53755080
90CSNK1A1L0.53689787
91PRKAA20.51848107
92ARAF0.50156463
93PIM20.49848825
94EGFR0.48968973
95RPS6KA50.47692376
96MAP3K40.47429139
97NTRK30.46592003
98FGFR20.44551213
99PIM10.43397079
100PRKACA0.43256827

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.11477258
2Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.72688574
3Phototransduction_Homo sapiens_hsa047442.68944604
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.44327842
5Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.41833953
6Primary immunodeficiency_Homo sapiens_hsa053402.37869787
7Allograft rejection_Homo sapiens_hsa053302.35183346
8Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.23503728
9Regulation of autophagy_Homo sapiens_hsa041402.21927972
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.14571637
11Asthma_Homo sapiens_hsa053102.11401318
12Selenocompound metabolism_Homo sapiens_hsa004502.07706070
13Autoimmune thyroid disease_Homo sapiens_hsa053202.04844686
14T cell receptor signaling pathway_Homo sapiens_hsa046602.01261718
15Linoleic acid metabolism_Homo sapiens_hsa005911.86650080
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.78701376
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.64189887
18Olfactory transduction_Homo sapiens_hsa047401.62892866
19Type I diabetes mellitus_Homo sapiens_hsa049401.62232546
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.59612386
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.49787568
22Hematopoietic cell lineage_Homo sapiens_hsa046401.49089419
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.42513306
24Graft-versus-host disease_Homo sapiens_hsa053321.42175355
25Proteasome_Homo sapiens_hsa030501.39230739
26Protein export_Homo sapiens_hsa030601.36431613
27RNA polymerase_Homo sapiens_hsa030201.35251835
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.34646538
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.29567779
30Taste transduction_Homo sapiens_hsa047421.23785911
31Peroxisome_Homo sapiens_hsa041461.22322362
32Arachidonic acid metabolism_Homo sapiens_hsa005901.20486847
33Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.16114358
34Chemical carcinogenesis_Homo sapiens_hsa052041.15613687
35Retinol metabolism_Homo sapiens_hsa008301.14862625
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.14281629
37Fanconi anemia pathway_Homo sapiens_hsa034601.11800494
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.10510639
39Shigellosis_Homo sapiens_hsa051311.10162463
40Maturity onset diabetes of the young_Homo sapiens_hsa049501.10000252
41Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.08749744
42Tryptophan metabolism_Homo sapiens_hsa003801.03882594
43Oxidative phosphorylation_Homo sapiens_hsa001901.03608301
44Nicotine addiction_Homo sapiens_hsa050331.03597514
45Serotonergic synapse_Homo sapiens_hsa047261.02167803
46Butanoate metabolism_Homo sapiens_hsa006501.01737657
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.01260094
48SNARE interactions in vesicular transport_Homo sapiens_hsa041301.00794831
49Parkinsons disease_Homo sapiens_hsa050120.98893935
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.97778774
51Purine metabolism_Homo sapiens_hsa002300.94614761
52NOD-like receptor signaling pathway_Homo sapiens_hsa046210.94077157
53Ovarian steroidogenesis_Homo sapiens_hsa049130.89446922
54Pertussis_Homo sapiens_hsa051330.85732982
55Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85237983
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82794547
57Alzheimers disease_Homo sapiens_hsa050100.81607956
58Ether lipid metabolism_Homo sapiens_hsa005650.81376547
59Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.80736378
60Systemic lupus erythematosus_Homo sapiens_hsa053220.77792936
61Renin secretion_Homo sapiens_hsa049240.77010121
62Ribosome_Homo sapiens_hsa030100.76632786
63RNA degradation_Homo sapiens_hsa030180.75060557
64Morphine addiction_Homo sapiens_hsa050320.72591320
65Aldosterone synthesis and secretion_Homo sapiens_hsa049250.71873806
66GABAergic synapse_Homo sapiens_hsa047270.71452741
67Cocaine addiction_Homo sapiens_hsa050300.68806301
68Oxytocin signaling pathway_Homo sapiens_hsa049210.66863873
69Salmonella infection_Homo sapiens_hsa051320.65939111
70Pyrimidine metabolism_Homo sapiens_hsa002400.64715195
71Calcium signaling pathway_Homo sapiens_hsa040200.64183071
72Rheumatoid arthritis_Homo sapiens_hsa053230.63883601
73Circadian entrainment_Homo sapiens_hsa047130.61294559
74Alcoholism_Homo sapiens_hsa050340.61178102
75Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.60918554
76VEGF signaling pathway_Homo sapiens_hsa043700.60810023
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.59574147
78Measles_Homo sapiens_hsa051620.59111142
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58696580
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.57348734
81Amphetamine addiction_Homo sapiens_hsa050310.56061162
82Dopaminergic synapse_Homo sapiens_hsa047280.50666091
83Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.50449251
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.49676168
85Jak-STAT signaling pathway_Homo sapiens_hsa046300.49604162
86Collecting duct acid secretion_Homo sapiens_hsa049660.45526965
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44717431
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.43167738
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43008581
90Cardiac muscle contraction_Homo sapiens_hsa042600.42353730
91N-Glycan biosynthesis_Homo sapiens_hsa005100.42211139
92NF-kappa B signaling pathway_Homo sapiens_hsa040640.42028302
93Leishmaniasis_Homo sapiens_hsa051400.41356484
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41126900
95Salivary secretion_Homo sapiens_hsa049700.40323495
96Toll-like receptor signaling pathway_Homo sapiens_hsa046200.39844899
97Glycerolipid metabolism_Homo sapiens_hsa005610.39465774
98African trypanosomiasis_Homo sapiens_hsa051430.39260468
99Antigen processing and presentation_Homo sapiens_hsa046120.39227866
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38928290

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