IER3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. Partially degraded and unspliced transcripts are found after virus infection in vitro, but these transcripts are not found in vivo and do not generate a valid protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of vitamin D biosynthetic process (GO:0060556)6.56201015
2regulation of vitamin metabolic process (GO:0030656)5.20088045
3positive regulation of membrane protein ectodomain proteolysis (GO:0051044)4.65095115
4regulation of cytokine secretion involved in immune response (GO:0002739)4.42978787
5regulation of chemokine biosynthetic process (GO:0045073)4.37178290
6regulation of membrane protein ectodomain proteolysis (GO:0051043)4.35543166
7negative regulation of interleukin-12 production (GO:0032695)4.24273675
8regulation of chronic inflammatory response (GO:0002676)4.07401440
9NIK/NF-kappaB signaling (GO:0038061)4.04061364
10wound healing, spreading of epidermal cells (GO:0035313)3.97360638
11positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.91689755
12activation of MAPKKK activity (GO:0000185)3.77062777
13neutrophil activation involved in immune response (GO:0002283)3.65997921
14regulation of heat generation (GO:0031650)3.63087616
15negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.62653921
16branching involved in labyrinthine layer morphogenesis (GO:0060670)3.61820937
17positive regulation of NF-kappaB import into nucleus (GO:0042346)3.56555427
18regulation of T-helper 1 cell differentiation (GO:0045625)3.53289799
19positive regulation of nitric oxide biosynthetic process (GO:0045429)3.47321814
20cell adhesion mediated by integrin (GO:0033627)3.46779264
21regulation of nitric oxide biosynthetic process (GO:0045428)3.43864959
22T-helper 1 type immune response (GO:0042088)3.41744975
23positive regulation of p38MAPK cascade (GO:1900745)3.40437658
24positive regulation of osteoblast proliferation (GO:0033690)3.39199252
25oligosaccharide catabolic process (GO:0009313)3.38664136
26negative regulation of nitric oxide biosynthetic process (GO:0045019)3.36733460
27wound healing, spreading of cells (GO:0044319)3.31547662
28negative regulation of lipid storage (GO:0010888)3.27493403
29protein localization to endosome (GO:0036010)3.24533532
30germinal center formation (GO:0002467)3.23320826
31glycosphingolipid catabolic process (GO:0046479)3.22487631
32myeloid dendritic cell differentiation (GO:0043011)3.22075813
33negative regulation of cytokine production involved in immune response (GO:0002719)3.20350022
34cellular response to lipopolysaccharide (GO:0071222)3.20033948
35endothelial cell morphogenesis (GO:0001886)3.15566474
36regulation of T-helper 2 cell differentiation (GO:0045628)3.14965619
37positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.14951535
38lymph vessel development (GO:0001945)3.13757589
39response to muramyl dipeptide (GO:0032495)3.13716238
40virion attachment to host cell (GO:0019062)3.12961168
41adhesion of symbiont to host cell (GO:0044650)3.12961168
42regulation of immunoglobulin secretion (GO:0051023)3.10535803
43hemidesmosome assembly (GO:0031581)3.09407831
44regulation of chemokine secretion (GO:0090196)3.08594132
45regulation of interferon-alpha production (GO:0032647)3.07446741
46positive regulation by symbiont of host defense response (GO:0052509)3.05941113
47modulation by symbiont of host defense response (GO:0052031)3.05941113
48modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.05941113
49modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.05941113
50positive regulation by organism of defense response of other organism involved in symbiotic interact3.05941113
51modulation by symbiont of host immune response (GO:0052553)3.05941113
52regulation of heterotypic cell-cell adhesion (GO:0034114)3.05405364
53cellular response to molecule of bacterial origin (GO:0071219)3.04623660
54positive regulation of acute inflammatory response (GO:0002675)3.01515512
55regulation of NF-kappaB import into nucleus (GO:0042345)3.00446391
56low-density lipoprotein particle clearance (GO:0034383)2.96502623
57monocyte chemotaxis (GO:0002548)2.96204393
58negative regulation of myeloid cell apoptotic process (GO:0033033)2.95462255
59positive regulation of astrocyte differentiation (GO:0048711)2.93991544
60positive regulation of transcription factor import into nucleus (GO:0042993)2.93459815
61response to laminar fluid shear stress (GO:0034616)2.91985890
62positive regulation of chemokine secretion (GO:0090197)2.88019924
63cellular extravasation (GO:0045123)2.86497441
64glycolipid catabolic process (GO:0019377)2.86251526
65skin morphogenesis (GO:0043589)2.86177053
66eosinophil chemotaxis (GO:0048245)2.85461956
67adhesion of symbiont to host (GO:0044406)2.85086675
68microglial cell activation (GO:0001774)2.83852734
69positive regulation of hair follicle development (GO:0051798)2.83000533
70positive regulation of hair cycle (GO:0042635)2.83000533
71type I interferon signaling pathway (GO:0060337)2.82399160
72cellular response to type I interferon (GO:0071357)2.82399160
73regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.81744921
74positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.81677970
75mesodermal cell differentiation (GO:0048333)2.80982172
76response to type I interferon (GO:0034340)2.78334212
77cellular response to arsenic-containing substance (GO:0071243)2.76903910
78positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.76512872
79defense response to protozoan (GO:0042832)2.76368582
80positive regulation of macrophage differentiation (GO:0045651)2.75794405
81response to peptidoglycan (GO:0032494)2.75734272
82macrophage activation (GO:0042116)2.73565860
83positive regulation of type 2 immune response (GO:0002830)2.72976261
84cellular response to nicotine (GO:0071316)2.72975622
85substrate-dependent cell migration (GO:0006929)2.72662309
86cellular response to thyroid hormone stimulus (GO:0097067)2.71281559
87regulation of interleukin-8 biosynthetic process (GO:0045414)2.70827765
88regulation of vascular endothelial growth factor production (GO:0010574)2.70466513
89response to progesterone (GO:0032570)2.69164149
90decidualization (GO:0046697)2.69120931
91positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.68441072
92cellular response to biotic stimulus (GO:0071216)2.67389667
93lipopolysaccharide-mediated signaling pathway (GO:0031663)2.67274431
94positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.65956946
95eosinophil migration (GO:0072677)2.65870137
96regulation of mononuclear cell migration (GO:0071675)2.64394593
97atrioventricular valve morphogenesis (GO:0003181)2.63931293
98regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.63816415
99positive regulation of chemokine biosynthetic process (GO:0045080)2.62933430
100regulation of interleukin-6 production (GO:0032675)2.62740335
101macrophage activation involved in immune response (GO:0002281)2.61514791
102tyrosine phosphorylation of STAT protein (GO:0007260)2.60121046
103lymphangiogenesis (GO:0001946)2.59425593
104regulation of interleukin-12 biosynthetic process (GO:0045075)2.58599832
105membrane lipid catabolic process (GO:0046466)2.57698604
106regulation of type I interferon-mediated signaling pathway (GO:0060338)2.57516453
107modulation by symbiont of host cellular process (GO:0044068)2.55557506
108myeloid dendritic cell activation (GO:0001773)2.55032334
109regulation of macrophage cytokine production (GO:0010935)2.54978970
110vascular endothelial growth factor signaling pathway (GO:0038084)2.54767690
111positive regulation of cellular amide metabolic process (GO:0034250)2.54315531
112positive regulation of endothelial cell apoptotic process (GO:2000353)2.53321588
113establishment of endothelial barrier (GO:0061028)2.53198317
114endothelium development (GO:0003158)2.52615176
115positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.51997656
116sphingosine metabolic process (GO:0006670)2.50624981
117collagen fibril organization (GO:0030199)2.50331648
118negative regulation of production of molecular mediator of immune response (GO:0002701)2.50042022
119production of molecular mediator involved in inflammatory response (GO:0002532)2.49678284
120granulocyte activation (GO:0036230)2.49452564
121regulation of cholesterol storage (GO:0010885)2.49387601
122lung vasculature development (GO:0060426)2.48594553
123neutrophil activation (GO:0042119)2.48462693
124regulation of mast cell degranulation (GO:0043304)2.48119372
125glial cell migration (GO:0008347)2.47514151
126lipoxygenase pathway (GO:0019372)2.47025417
127positive regulation of interferon-alpha production (GO:0032727)2.47012575
128detection of molecule of bacterial origin (GO:0032490)2.46887451
129ceramide catabolic process (GO:0046514)2.45326600
130positive regulation of T-helper cell differentiation (GO:0045624)2.45298562
131positive regulation of chemokine production (GO:0032722)2.45202871
132response to fluid shear stress (GO:0034405)2.44086482
133regulation of integrin-mediated signaling pathway (GO:2001044)2.43805331
134lung lobe morphogenesis (GO:0060463)2.43565453
135positive regulation of odontogenesis (GO:0042482)2.41569853
136regulation of podosome assembly (GO:0071801)2.41242885
137positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.40265367
138surfactant homeostasis (GO:0043129)2.39624930
139regulation of p38MAPK cascade (GO:1900744)2.39217294
140negative regulation of mast cell activation (GO:0033004)2.38266833
141regulation of mast cell activation involved in immune response (GO:0033006)2.37603595
142antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.36675893
143hyaluronan catabolic process (GO:0030214)2.36464378
144cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.35758662
145angiogenesis involved in wound healing (GO:0060055)2.35330645
146regulation of interferon-beta biosynthetic process (GO:0045357)2.35096412
147positive regulation of mast cell degranulation (GO:0043306)2.34945979
148positive regulation of mast cell activation involved in immune response (GO:0033008)2.34945979
149regulation of monocyte chemotaxis (GO:0090025)2.34856359
150keratan sulfate catabolic process (GO:0042340)2.33654072
151blood vessel remodeling (GO:0001974)2.30716784
152positive regulation of leukocyte degranulation (GO:0043302)2.29078997
153positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.28636918
154regulation of endothelial cell differentiation (GO:0045601)2.28139189
155chondrocyte proliferation (GO:0035988)2.27984227
156fibroblast migration (GO:0010761)2.27874107
157endodermal cell differentiation (GO:0035987)2.27804379
158regulation of dendritic cell antigen processing and presentation (GO:0002604)2.27715295
159regulation of fever generation (GO:0031620)2.26174428
160positive regulation of monocyte chemotaxis (GO:0090026)2.24509190
161response to interferon-alpha (GO:0035455)2.24479971
162response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.22995040
163response to host immune response (GO:0052572)2.22995040
164positive regulation of interleukin-6 production (GO:0032755)2.22419811
165immunoglobulin mediated immune response (GO:0016064)2.20200713
166positive regulation of heat generation (GO:0031652)2.20117324
167response to host (GO:0075136)2.19609238
168response to host defenses (GO:0052200)2.19609238
169response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.19609238
170response to interferon-beta (GO:0035456)2.19457354
171regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.19274642
172morphogenesis of an endothelium (GO:0003159)2.19055544
173endothelial tube morphogenesis (GO:0061154)2.19055544
174retina vasculature morphogenesis in camera-type eye (GO:0061299)2.18883550

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.92281017
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.86600076
3TRIM28_21343339_ChIP-Seq_HEK293_Human4.78127521
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.41918853
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.77582125
6RARG_19884340_ChIP-ChIP_MEFs_Mouse3.68065885
7ESR1_21235772_ChIP-Seq_MCF-7_Human3.13467012
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.12901119
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.01276306
10* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.89416484
11SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.81875525
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.56218736
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.40653499
14GATA2_21666600_ChIP-Seq_HMVEC_Human2.33216530
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.32143416
16HIF1A_21447827_ChIP-Seq_MCF-7_Human2.31199794
17IRF8_21731497_ChIP-ChIP_J774_Mouse2.25622335
18* ESR2_21235772_ChIP-Seq_MCF-7_Human2.17475353
19CLOCK_20551151_ChIP-Seq_293T_Human2.16583883
20* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.15545216
21TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.10401987
22* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.08239849
23STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.06275304
24* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.05259985
25* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.05259985
26* CJUN_26792858_Chip-Seq_BT549_Human2.02471555
27* IRF8_27001747_Chip-Seq_BMDM_Mouse2.02359953
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.99565008
29VDR_21846776_ChIP-Seq_THP-1_Human1.97671792
30SOX2_20726797_ChIP-Seq_SW620_Human1.80342284
31LXR_22292898_ChIP-Seq_THP-1_Human1.79584318
32* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.78811759
33TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.78254742
34ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.77562661
35STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.74221719
36SMAD_19615063_ChIP-ChIP_OVARY_Human1.71241588
37CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.67959139
38* ELK3_25401928_ChIP-Seq_HUVEC_Human1.65205525
39CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.64727116
40* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.61860809
41PPAR_26484153_Chip-Seq_NCI-H1993_Human1.59095879
42* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.53730473
43JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.53718427
44CDX2_20551321_ChIP-Seq_CACO-2_Human1.53122531
45KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.49001389
46PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.48837611
47WT1_19549856_ChIP-ChIP_CCG9911_Human1.48518166
48SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.46912694
49MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.45543154
50STAT6_21828071_ChIP-Seq_BEAS2B_Human1.44897022
51NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.41674560
52NRF2_20460467_ChIP-Seq_MEFs_Mouse1.41674560
53VDR_24787735_ChIP-Seq_THP-1_Human1.38848246
54PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.37812987
55* FOXO3_23340844_ChIP-Seq_DLD1_Human1.37104112
56SCL_19346495_ChIP-Seq_HPC-7_Human1.36699020
57JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36598715
58* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.34178717
59KDM2B_26808549_Chip-Seq_DND41_Human1.33216030
60BRD4_27068464_Chip-Seq_AML-cells_Mouse1.30360613
61FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28380532
62NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.27001208
63ZNF217_24962896_ChIP-Seq_MCF-7_Human1.22869077
64TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.22743988
65KDM2B_26808549_Chip-Seq_K562_Human1.21934281
66CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21648025
67CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21329239
68PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20802065
69KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.20515263
70SPI1_23127762_ChIP-Seq_K562_Human1.20413632
71MYC_22102868_ChIP-Seq_BL_Human1.19797891
72* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.19389545
73SOX9_24532713_ChIP-Seq_HFSC_Mouse1.19385582
74SALL4_18804426_ChIP-ChIP_XEN_Mouse1.18800285
75ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.18690604
76TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18496594
77* UBF1/2_26484160_Chip-Seq_HMECs_Human1.17703314
78VDR_24763502_ChIP-Seq_THP-1_Human1.17626500
79FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.15723453
80* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.15687196
81BRD4_25478319_ChIP-Seq_HGPS_Human1.14652789
82E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.14319549
83* RUNX_20019798_ChIP-Seq_JUKART_Human1.12089899
84EP300_21415370_ChIP-Seq_HL-1_Mouse1.11422686
85UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.11045687
86P300_27058665_Chip-Seq_ZR-75-30cells_Human1.09744399
87NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.09725772
88ATF3_27146783_Chip-Seq_COLON_Human1.09645346
89EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.09021163
90KDM2B_26808549_Chip-Seq_SUP-B15_Human1.08912082
91SPI1_23547873_ChIP-Seq_NB4_Human1.07585582
92SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07243963
93SMC1_22415368_ChIP-Seq_MEFs_Mouse1.07238907
94TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07201125
95RXR_22158963_ChIP-Seq_LIVER_Mouse1.06884473
96MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.06855417
97TP53_18474530_ChIP-ChIP_U2OS_Human1.06522682
98TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06276998
99IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.06143618
100TP53_22127205_ChIP-Seq_IMR90_Human1.01449306
101PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00716611
102ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.99501596
103ZNF263_19887448_ChIP-Seq_K562_Human0.98538478
104TFEB_21752829_ChIP-Seq_HELA_Human0.97623784
105VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.97321303
106IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.97173202
107ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.96954789
108DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.96771044
109* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.96223689
110KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96101108
111THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.96038947
112CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95610708
113FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.94104727
114PPARA_22158963_ChIP-Seq_LIVER_Mouse0.93816153
115CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93693444
116HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93284612
117RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.92024084
118KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.91818233
119RACK7_27058665_Chip-Seq_MCF-7_Human0.91116867
120PU_27001747_Chip-Seq_BMDM_Mouse0.90968202
121KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.89987033
122KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.89987033
123KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.89987033
124MAF_26560356_Chip-Seq_TH1_Human0.89956714
125RUNX1_22412390_ChIP-Seq_EML_Mouse0.89600620
126EGR1_19032775_ChIP-ChIP_M12_Human0.89495661
127CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.88533796
128KLF5_25053715_ChIP-Seq_YYC3_Human0.86028015
129PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85836907
130MYB_26560356_Chip-Seq_TH2_Human0.85027693
131TCF7_22412390_ChIP-Seq_EML_Mouse0.83801323
132NFIB_24661679_ChIP-Seq_LUNG_Mouse0.83679991
133* GATA2_19941826_ChIP-Seq_K562_Human0.80196714
134CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78592294
135* TP63_23658742_ChIP-Seq_EP156T_Human0.77501567

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009840_abnormal_foam_cell3.45012943
2MP0003724_increased_susceptibility_to3.34135646
3MP0008438_abnormal_cutaneous_collagen3.28171039
4MP0010368_abnormal_lymphatic_system3.03457124
5MP0003436_decreased_susceptibility_to2.79107265
6MP0005275_abnormal_skin_tensile2.77067369
7MP0003279_aneurysm2.44391622
8MP0003303_peritoneal_inflammation2.44227631
9MP0003566_abnormal_cell_adhesion2.33777756
10MP0005451_abnormal_body_composition2.29827291
11MP0001879_abnormal_lymphatic_vessel2.25572077
12MP0000343_altered_response_to2.25070254
13MP0002148_abnormal_hypersensitivity_rea2.22961052
14MP0001533_abnormal_skeleton_physiology2.22892834
15MP0002139_abnormal_hepatobiliary_system2.22076327
16MP0005023_abnormal_wound_healing2.18346816
17MP0006054_spinal_hemorrhage2.13650611
18MP0004272_abnormal_basement_membrane2.10655477
19MP0009785_altered_susceptibility_to2.10514579
20MP0005503_abnormal_tendon_morphology2.07000875
21MP0003828_pulmonary_edema1.99552250
22MP0003705_abnormal_hypodermis_morpholog1.89243474
23MP0001958_emphysema1.87199175
24MP0005164_abnormal_response_to1.86357701
25MP0002419_abnormal_innate_immunity1.86092066
26MP0010352_gastrointestinal_tract_polyps1.84988932
27MP0002332_abnormal_exercise_endurance1.81686632
28MP0002254_reproductive_system_inflammat1.77575297
29MP0001835_abnormal_antigen_presentation1.77202029
30MP0005390_skeleton_phenotype1.73201042
31MP0002933_joint_inflammation1.70709690
32MP0003300_gastrointestinal_ulcer1.70694245
33MP0003191_abnormal_cellular_cholesterol1.68968232
34MP0001853_heart_inflammation1.65545107
35MP0001542_abnormal_bone_strength1.64718860
36MP0003453_abnormal_keratinocyte_physiol1.61359022
37MP0003448_altered_tumor_morphology1.60768921
38MP0008004_abnormal_stomach_pH1.60592206
39MP0002060_abnormal_skin_morphology1.60510118
40MP0004883_abnormal_blood_vessel1.60253497
41MP0005000_abnormal_immune_tolerance1.59224706
42MP0003172_abnormal_lysosome_physiology1.57759624
43MP0009278_abnormal_bone_marrow1.57719688
44MP0000604_amyloidosis1.55920416
45MP0004510_myositis1.52472788
46MP0001851_eye_inflammation1.50883987
47MP0005167_abnormal_blood-brain_barrier1.50794012
48MP0000858_altered_metastatic_potential1.50096487
49MP0002998_abnormal_bone_remodeling1.49306718
50MP0004947_skin_inflammation1.47851671
51MP0003091_abnormal_cell_migration1.44229240
52MP0005671_abnormal_response_to1.42873663
53MP0005623_abnormal_meninges_morphology1.42221238
54MP0000767_abnormal_smooth_muscle1.41251613
55MP0002295_abnormal_pulmonary_circulatio1.40652084
56MP0005025_abnormal_response_to1.40149723
57MP0005508_abnormal_skeleton_morphology1.38848917
58MP0009764_decreased_sensitivity_to1.38642253
59MP0002405_respiratory_system_inflammati1.38241453
60MP0003045_fibrosis1.35100332
61MP0003806_abnormal_nucleotide_metabolis1.34946605
62MP0001790_abnormal_immune_system1.33308806
63MP0005387_immune_system_phenotype1.33308806
64MP0000249_abnormal_blood_vessel1.32901648
65MP0003075_altered_response_to1.31786296
66MP0000465_gastrointestinal_hemorrhage1.31694618
67MP0002452_abnormal_antigen_presenting1.31682482
68MP0010155_abnormal_intestine_physiology1.28923360
69MP0002282_abnormal_trachea_morphology1.24749953
70MP0002877_abnormal_melanocyte_morpholog1.23530212
71MP0006082_CNS_inflammation1.22292058
72MP0005166_decreased_susceptibility_to1.19735004
73MP0005076_abnormal_cell_differentiation1.18601361
74MP0003656_abnormal_erythrocyte_physiolo1.15758608
75MP0005397_hematopoietic_system_phenotyp1.14358627
76MP0001545_abnormal_hematopoietic_system1.14358627
77MP0000685_abnormal_immune_system1.13702874
78MP0003941_abnormal_skin_development1.11995070
79MP0000750_abnormal_muscle_regeneration1.11018328
80MP0005464_abnormal_platelet_physiology1.08247878
81MP0002723_abnormal_immune_serum1.07969524
82MP0005165_increased_susceptibility_to1.06354585
83MP0004808_abnormal_hematopoietic_stem1.05332618
84MP0001845_abnormal_inflammatory_respons1.05306045
85MP0003795_abnormal_bone_structure1.05277729
86MP0009384_cardiac_valve_regurgitation1.03556341
87MP0010234_abnormal_vibrissa_follicle1.03216230
88MP0001819_abnormal_immune_cell1.00050060
89MP0002420_abnormal_adaptive_immunity0.99982610
90MP0001800_abnormal_humoral_immune0.98598730
91MP0004782_abnormal_surfactant_physiolog0.98426659
92MP0005257_abnormal_intraocular_pressure0.97131033
93MP0002138_abnormal_hepatobiliary_system0.96646249
94MP0003690_abnormal_glial_cell0.96072918
95MP0005310_abnormal_salivary_gland0.95189389
96MP0001216_abnormal_epidermal_layer0.94585514
97MP0001849_ear_inflammation0.93952842
98MP0005058_abnormal_lysosome_morphology0.92894576
99MP0003329_amyloid_beta_deposits0.92818163
100MP0008260_abnormal_autophagy0.92230341
101MP0005595_abnormal_vascular_smooth0.92149974
102MP0002896_abnormal_bone_mineralization0.91073235
103MP0005367_renal/urinary_system_phenotyp0.87347714
104MP0000516_abnormal_urinary_system0.87347714
105MP0001243_abnormal_dermal_layer0.84094365
106MP0001614_abnormal_blood_vessel0.81631197
107MP0003950_abnormal_plasma_membrane0.81581737
108MP0009763_increased_sensitivity_to0.79946401
109MP0002113_abnormal_skeleton_development0.79247839
110MP0001727_abnormal_embryo_implantation0.77596339
111MP0000716_abnormal_immune_system0.77537090
112MP0001881_abnormal_mammary_gland0.76257110
113MP0008469_abnormal_protein_level0.76057875
114MP0009765_abnormal_xenobiotic_induced0.75963229
115MP0002133_abnormal_respiratory_system0.75128761
116MP0005388_respiratory_system_phenotype0.75128761
117MP0005197_abnormal_uvea_morphology0.75029437
118MP0000163_abnormal_cartilage_morphology0.74485474
119MP0001191_abnormal_skin_condition0.74031967
120MP0009333_abnormal_splenocyte_physiolog0.73909033
121MP0003195_calcinosis0.70668070
122MP0008874_decreased_physiological_sensi0.69196302
123MP0000920_abnormal_myelination0.68173110
124MP0004233_abnormal_muscle_weight0.67234954
125MP0001663_abnormal_digestive_system0.65937426
126MP0002796_impaired_skin_barrier0.63126222
127MP0010307_abnormal_tumor_latency0.62609419
128MP0004858_abnormal_nervous_system0.61566826

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)6.73601395
2Abnormality of liposaccharide metabolism (HP:0010968)6.73601395
3Abnormality of glycosphingolipid metabolism (HP:0004343)6.73601395
4Loss of speech (HP:0002371)4.24801485
5Premature rupture of membranes (HP:0001788)4.06835248
6Nuclear cataract (HP:0100018)3.99353532
7Neurofibrillary tangles (HP:0002185)3.91563331
8Eczematoid dermatitis (HP:0000976)3.73821992
9Atrophic scars (HP:0001075)3.68365061
10Disinhibition (HP:0000734)3.67273917
11Recurrent abscess formation (HP:0002722)3.48640005
12Protrusio acetabuli (HP:0003179)3.47674785
13Vascular tortuosity (HP:0004948)3.31956541
14Interstitial pulmonary disease (HP:0006530)3.31046912
15Abnormality of polysaccharide metabolism (HP:0011012)3.29353461
16Abnormality of glycosaminoglycan metabolism (HP:0004371)3.29353461
17Abnormality of mucopolysaccharide metabolism (HP:0011020)3.29353461
18Aortic dissection (HP:0002647)3.15970153
19Aortic aneurysm (HP:0004942)3.06282603
20Arterial tortuosity (HP:0005116)3.05877041
21Cervical subluxation (HP:0003308)3.01617705
22Vertebral compression fractures (HP:0002953)2.99718211
23Cerebral inclusion bodies (HP:0100314)2.98869668
24Cerebral aneurysm (HP:0004944)2.98683025
25Myositis (HP:0100614)2.95178016
26Recurrent bacterial skin infections (HP:0005406)2.95015854
27Orchitis (HP:0100796)2.94764482
28Hematochezia (HP:0002573)2.89101441
29Osteolytic defects of the hand bones (HP:0009699)2.88002545
30Osteolytic defects of the phalanges of the hand (HP:0009771)2.88002545
31Autoimmune thrombocytopenia (HP:0001973)2.86559148
32Mutism (HP:0002300)2.85549268
33Systemic lupus erythematosus (HP:0002725)2.85224806
34Apathy (HP:0000741)2.84102033
35Stomatitis (HP:0010280)2.77539321
36Amyloidosis (HP:0011034)2.76906471
37Onycholysis (HP:0001806)2.74302584
38Increased serum ferritin (HP:0003281)2.73032250
39Diminished motivation (HP:0000745)2.72433554
40Epiphyseal dysplasia (HP:0002656)2.70116755
41Pustule (HP:0200039)2.68663774
42Fragile skin (HP:0001030)2.63052110
43Axonal loss (HP:0003447)2.62984337
44Distal lower limb muscle weakness (HP:0009053)2.61351222
45Thick nail (HP:0001805)2.60480411
46Vitreoretinal degeneration (HP:0000655)2.48288333
47Vacuolated lymphocytes (HP:0001922)2.46021037
48Prolonged neonatal jaundice (HP:0006579)2.43658462
49Right ventricular cardiomyopathy (HP:0011663)2.43356427
50Increased neuronal autofluorescent lipopigment (HP:0002074)2.41232877
51Achilles tendon contracture (HP:0001771)2.40862359
52Peritonitis (HP:0002586)2.40219301
53Spontaneous hematomas (HP:0007420)2.39891460
54Neuronal loss in central nervous system (HP:0002529)2.39866170
55Milia (HP:0001056)2.39650229
56Abnormality of macrophages (HP:0004311)2.36425818
57Metaphyseal irregularity (HP:0003025)2.35536561
58Alopecia of scalp (HP:0002293)2.35054196
59Increased cerebral lipofuscin (HP:0011813)2.33364736
60Pulmonary artery stenosis (HP:0004415)2.29363665
61Abnormality of the distal phalanges of the toes (HP:0010182)2.28395978
62Thin bony cortex (HP:0002753)2.27790263
63Progressive neurologic deterioration (HP:0002344)2.25864533
64Elevated erythrocyte sedimentation rate (HP:0003565)2.24288160
65Beaking of vertebral bodies (HP:0004568)2.23811519
66Retrobulbar optic neuritis (HP:0100654)2.20086186
67Optic neuritis (HP:0100653)2.20086186
68Hyperparathyroidism (HP:0000843)2.19735014
69Dilatation of the ascending aorta (HP:0005111)2.18785092
70Neonatal short-limb short stature (HP:0008921)2.18678114
71Soft skin (HP:0000977)2.16923756
72Malnutrition (HP:0004395)2.16686047
73Abnormality of the Achilles tendon (HP:0005109)2.15054130
74Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.13636800
75Anhidrosis (HP:0000970)2.13320928
76Keratoconjunctivitis sicca (HP:0001097)2.12907517
77Joint stiffness (HP:0001387)2.12394784
78Flat acetabular roof (HP:0003180)2.11136701
79Parakeratosis (HP:0001036)2.10781929
80Bone pain (HP:0002653)2.10532165
81Spinal rigidity (HP:0003306)2.08801788
82Glomerulonephritis (HP:0000099)2.08782670
83Shallow orbits (HP:0000586)2.08673859
84Upper motor neuron abnormality (HP:0002127)2.08321228
85Wormian bones (HP:0002645)2.07708623
86Abnormality of proline metabolism (HP:0010907)2.06293453
87Hydroxyprolinuria (HP:0003080)2.06293453
88Abnormality of the vasculature of the conjunctiva (HP:0008054)2.05974805
89Spondylolisthesis (HP:0003302)2.05811786
90Plantar hyperkeratosis (HP:0007556)2.05392615
91Cellulitis (HP:0100658)2.04860001
92Cupped ribs (HP:0000887)2.03927894
93Broad metatarsal (HP:0001783)2.03323188
94Short hallux (HP:0010109)2.02654813
95Short nail (HP:0001799)2.01839389
96Complement deficiency (HP:0004431)2.00867412
97Segmental peripheral demyelination/remyelination (HP:0003481)2.00570835
98Mediastinal lymphadenopathy (HP:0100721)1.98741743
99Nephritis (HP:0000123)1.98609308
100Myocardial infarction (HP:0001658)1.98275300
101Purpura (HP:0000979)1.98238065
102Pathologic fracture (HP:0002756)1.96637742
103Gangrene (HP:0100758)1.94804063
104Supranuclear gaze palsy (HP:0000605)1.94715200
105Gingivitis (HP:0000230)1.94092647
106Fragile nails (HP:0001808)1.92992163
107Abnormality of complement system (HP:0005339)1.92043326
108Asymmetric septal hypertrophy (HP:0001670)1.91889981
109Pulmonary infiltrates (HP:0002113)1.91394567
110J-shaped sella turcica (HP:0002680)1.90205046
111Basal ganglia calcification (HP:0002135)1.87701506
112Abnormality of iron homeostasis (HP:0011031)1.87319499
113Increased connective tissue (HP:0009025)1.87303544
114Nausea (HP:0002018)1.84727472
115Abnormality of the nasal mucosa (HP:0000433)1.84707134
116Dementia (HP:0000726)1.84249002
117Blue sclerae (HP:0000592)1.83788835
118Aplasia/Hypoplasia of the hallux (HP:0008362)1.82918456
119Keratoconjunctivitis (HP:0001096)1.82594145
120Hepatosplenomegaly (HP:0001433)1.81887619
121Stomach cancer (HP:0012126)1.81407756
122Coxa vara (HP:0002812)1.79612862
123Esophageal varix (HP:0002040)1.79558189
124Platyspondyly (HP:0000926)1.78948646
125Petechiae (HP:0000967)1.78514488
126Hypoplastic ischia (HP:0003175)1.77859920
127Vasculitis (HP:0002633)1.77800620
128Dysostosis multiplex (HP:0000943)1.77475145
129Mitral valve prolapse (HP:0001634)1.77346785
130Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.74340360
131Abnormality of the odontoid process (HP:0003310)1.74316420
132Personality changes (HP:0000751)1.73677851
133Abnormality of the nasal septum (HP:0000419)1.73170817
134Ovoid vertebral bodies (HP:0003300)1.72655827
135Inappropriate behavior (HP:0000719)1.72111592
136Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.71734043
137Recurrent gram-negative bacterial infections (HP:0005420)1.71651173
138Abnormality of the pericardium (HP:0001697)1.71508254
139Deep venous thrombosis (HP:0002625)1.70302706
140Tetraparesis (HP:0002273)1.69308948
141Polyneuropathy (HP:0001271)1.68474364
142Prostate neoplasm (HP:0100787)1.68371890
143Zonular cataract (HP:0010920)1.67383707
144Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.66713010
145Osteoarthritis (HP:0002758)1.65896490
146Persistence of primary teeth (HP:0006335)1.64915490
147Hypoplasia of the odontoid process (HP:0003311)1.64448862
148Aneurysm (HP:0002617)1.63443912
149Polycythemia (HP:0001901)1.63059197
150Thoracolumbar scoliosis (HP:0002944)1.63025601
151Abnormality of the acetabulum (HP:0003170)1.62926845
152Abnormal vertebral ossification (HP:0100569)1.62449560
153Peripheral demyelination (HP:0011096)1.62179946
154Ankle contracture (HP:0006466)1.59896202
155Increased IgM level (HP:0003496)1.59625591
156Upper limb amyotrophy (HP:0009129)1.59302116
157Distal upper limb amyotrophy (HP:0007149)1.59302116
158Cardiomegaly (HP:0001640)1.59173964
159Prolonged bleeding time (HP:0003010)1.58990661
160Follicular hyperkeratosis (HP:0007502)1.58655754
161Urinary glycosaminoglycan excretion (HP:0003541)1.56517595
162Mucopolysacchariduria (HP:0008155)1.56517595

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.37496552
2PIM23.63826030
3TGFBR23.48672983
4MAP3K33.33011760
5MAP3K142.83687323
6TIE12.81779408
7ERN12.39028069
8TBK12.36298497
9EPHA32.24254265
10EPHB12.23399383
11PRPF4B1.92950272
12MST41.90054801
13EPHB21.86358906
14IKBKB1.84583216
15KDR1.66287506
16IKBKE1.60110520
17MAPK151.58251920
18LATS21.57774000
19SIK11.55277793
20BLK1.51852048
21TRPM71.51848845
22PAK41.48282049
23STK101.41070415
24FER1.40479193
25FGR1.40220703
26CDC42BPA1.39257915
27KIT1.38726310
28NEK91.35316086
29MYLK1.32432410
30CHUK1.28869786
31ICK1.28401697
32MAP2K21.26949160
33MAP2K31.26839513
34NME21.26597472
35ARAF1.23291589
36TYK21.22457725
37MATK1.20752760
38TTN1.20175167
39IRAK31.19271700
40PRKG21.19168736
41TESK11.18910169
42RIPK11.17092328
43LRRK21.15997424
44TGFBR11.15158695
45MAP3K131.11887914
46DDR21.11603247
47RPS6KA41.10738437
48IRAK21.09655713
49BMX1.08715392
50MAP3K111.08134597
51MAP3K121.05363458
52PIM11.02095542
53TEC0.96261228
54CSK0.95962956
55ZAP700.95436958
56PTK20.95345408
57JAK30.94127359
58PTK60.92261100
59MAP3K50.92133434
60IRAK40.92011265
61PBK0.90763621
62RPS6KB20.86170484
63JAK10.86016795
64SIK30.84252261
65PAK20.83992283
66TESK20.83955899
67FGFR40.82994480
68MOS0.81443550
69PTK2B0.80454536
70PDK20.79728936
71MAPKAPK30.79372006
72IRAK10.79276736
73MAPKAPK20.77913268
74FLT30.77684417
75CDK60.75172525
76MAP3K90.75091722
77TYRO30.73777250
78BTK0.73571462
79ERBB30.73520939
80MST1R0.71424935
81NLK0.70619119
82HCK0.70446262
83TAOK10.68442401
84BMPR20.68391654
85TAOK20.67874481
86PDGFRA0.67557612
87GSK3A0.67534099
88GRK70.66913158
89MAP3K10.66516589
90EIF2AK20.66326298
91NUAK10.66177785
92ABL20.65701610
93ADRBK20.63725657
94MET0.63434723
95PIK3CG0.62165202
96PDGFRB0.61977690
97TRIB30.61081908
98MAP2K10.60104587
99DYRK1B0.59171322
100ABL10.57048394
101ERBB40.55186571
102DAPK30.54178784
103EGFR0.52574535
104STK240.51511156
105STK30.51480854
106RIPK40.50821367
107RPS6KL10.50316510
108RPS6KC10.50316510
109LIMK10.49549389
110ZAK0.49343322
111MAPK40.48988975
112JAK20.47401987
113CLK10.46481903
114FGFR30.45900395
115DMPK0.45696474
116ITK0.44872640
117TXK0.44722929
118RPS6KA60.44274088
119LYN0.42087710
120CSF1R0.41810128
121MAP3K80.41104076
122MAP3K20.41027948
123SMG10.40191765
124GRK10.40123336
125MARK30.39828871
126MAP4K10.39581074
127HIPK20.38805470
128PDPK10.38626900
129BRAF0.38610369
130ACVR1B0.35870928
131MAP2K60.35558651
132PKN20.34351586
133LMTK20.34009119
134DYRK30.33391297
135RPS6KA20.32541595
136PRKD20.25690224
137MELK0.23744501
138MTOR0.23673082
139MAP3K60.22542983
140PAK10.20232887
141RPS6KA10.19715853
142MARK20.19145798

Predicted pathways (KEGG)

RankGene SetZ-score
1Malaria_Homo sapiens_hsa051442.81658737
2Leishmaniasis_Homo sapiens_hsa051402.75415366
3ECM-receptor interaction_Homo sapiens_hsa045122.30919782
4TNF signaling pathway_Homo sapiens_hsa046682.25474470
5Rheumatoid arthritis_Homo sapiens_hsa053232.21834502
6Legionellosis_Homo sapiens_hsa051342.19337901
7Osteoclast differentiation_Homo sapiens_hsa043802.03772193
8Pertussis_Homo sapiens_hsa051331.98079791
9AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.94927474
10Salmonella infection_Homo sapiens_hsa051321.85452287
11Toll-like receptor signaling pathway_Homo sapiens_hsa046201.83569409
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.83550939
13Toxoplasmosis_Homo sapiens_hsa051451.83434296
14NOD-like receptor signaling pathway_Homo sapiens_hsa046211.77373012
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.76240471
16Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.74546581
17Amoebiasis_Homo sapiens_hsa051461.72080987
18Staphylococcus aureus infection_Homo sapiens_hsa051501.71635399
19Hematopoietic cell lineage_Homo sapiens_hsa046401.65305881
20Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.64662456
21Leukocyte transendothelial migration_Homo sapiens_hsa046701.57699505
22Focal adhesion_Homo sapiens_hsa045101.57494990
23Shigellosis_Homo sapiens_hsa051311.52160958
24Small cell lung cancer_Homo sapiens_hsa052221.50251780
25Apoptosis_Homo sapiens_hsa042101.44265639
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.44207575
27Tuberculosis_Homo sapiens_hsa051521.41046807
28Phagosome_Homo sapiens_hsa041451.38592472
29Graft-versus-host disease_Homo sapiens_hsa053321.36730178
30Proteoglycans in cancer_Homo sapiens_hsa052051.36022012
31Asthma_Homo sapiens_hsa053101.35453807
32Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.33463324
33Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.32002436
34African trypanosomiasis_Homo sapiens_hsa051431.29441547
35Adherens junction_Homo sapiens_hsa045201.26562477
36Lysosome_Homo sapiens_hsa041421.22450097
37Bladder cancer_Homo sapiens_hsa052191.21224854
38Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.20184518
39Glycosaminoglycan degradation_Homo sapiens_hsa005311.19970141
40Measles_Homo sapiens_hsa051621.19872423
41Other glycan degradation_Homo sapiens_hsa005111.17232748
42Chronic myeloid leukemia_Homo sapiens_hsa052201.15764173
43TGF-beta signaling pathway_Homo sapiens_hsa043501.15208817
44Jak-STAT signaling pathway_Homo sapiens_hsa046301.14496295
45Influenza A_Homo sapiens_hsa051641.14061983
46Type I diabetes mellitus_Homo sapiens_hsa049401.06981111
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.03846653
48Platelet activation_Homo sapiens_hsa046111.03361646
49Hepatitis B_Homo sapiens_hsa051611.01506500
50RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.00773319
51HIF-1 signaling pathway_Homo sapiens_hsa040661.00178266
52Viral myocarditis_Homo sapiens_hsa054160.97365967
53Allograft rejection_Homo sapiens_hsa053300.95520934
54B cell receptor signaling pathway_Homo sapiens_hsa046620.95311946
55Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.94402396
56Autoimmune thyroid disease_Homo sapiens_hsa053200.93134308
57Chemokine signaling pathway_Homo sapiens_hsa040620.92630000
58PI3K-Akt signaling pathway_Homo sapiens_hsa041510.91130836
59Antigen processing and presentation_Homo sapiens_hsa046120.90015325
60Pancreatic cancer_Homo sapiens_hsa052120.89253071
61Intestinal immune network for IgA production_Homo sapiens_hsa046720.88197728
62Hepatitis C_Homo sapiens_hsa051600.87024695
63Acute myeloid leukemia_Homo sapiens_hsa052210.81553046
64MicroRNAs in cancer_Homo sapiens_hsa052060.81503999
65Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.81396056
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.81361633
67p53 signaling pathway_Homo sapiens_hsa041150.80782670
68Protein digestion and absorption_Homo sapiens_hsa049740.79821199
69Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.78225373
70Regulation of actin cytoskeleton_Homo sapiens_hsa048100.77744581
71Herpes simplex infection_Homo sapiens_hsa051680.76085211
72Dilated cardiomyopathy_Homo sapiens_hsa054140.74708328
73Arachidonic acid metabolism_Homo sapiens_hsa005900.73361292
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72965559
75Galactose metabolism_Homo sapiens_hsa000520.72149047
76Mineral absorption_Homo sapiens_hsa049780.71300059
77Complement and coagulation cascades_Homo sapiens_hsa046100.71246767
78HTLV-I infection_Homo sapiens_hsa051660.71050475
79Pathways in cancer_Homo sapiens_hsa052000.70286104
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68087813
81Rap1 signaling pathway_Homo sapiens_hsa040150.67713139
82Epstein-Barr virus infection_Homo sapiens_hsa051690.65343997
83T cell receptor signaling pathway_Homo sapiens_hsa046600.64437013
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63648039
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63436999
86Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.61732674
87Sulfur metabolism_Homo sapiens_hsa009200.60402010
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60329901
89Prostate cancer_Homo sapiens_hsa052150.58965912
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.58790035
91VEGF signaling pathway_Homo sapiens_hsa043700.57988604
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57329258
93Melanoma_Homo sapiens_hsa052180.56205083
94Fructose and mannose metabolism_Homo sapiens_hsa000510.55966698
95Prion diseases_Homo sapiens_hsa050200.54972803
96Hippo signaling pathway_Homo sapiens_hsa043900.53852561
97Renin-angiotensin system_Homo sapiens_hsa046140.52335743
98Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.52299929
99Prolactin signaling pathway_Homo sapiens_hsa049170.50170619
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50054720
101Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47696132
102Type II diabetes mellitus_Homo sapiens_hsa049300.47485080
103Sphingolipid metabolism_Homo sapiens_hsa006000.46929872
104Collecting duct acid secretion_Homo sapiens_hsa049660.46156072
105Viral carcinogenesis_Homo sapiens_hsa052030.45793218
106Notch signaling pathway_Homo sapiens_hsa043300.44598642
107Insulin resistance_Homo sapiens_hsa049310.44580728
108Renal cell carcinoma_Homo sapiens_hsa052110.44234943
109FoxO signaling pathway_Homo sapiens_hsa040680.43543123
110Vibrio cholerae infection_Homo sapiens_hsa051100.43052590
111Endocytosis_Homo sapiens_hsa041440.42469588
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.42213787
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.41738173
114Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38025907
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.37627357
116MAPK signaling pathway_Homo sapiens_hsa040100.35205204
117ErbB signaling pathway_Homo sapiens_hsa040120.33358302
118SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30963073
119Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27937757
120GnRH signaling pathway_Homo sapiens_hsa049120.24923432

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