IER3IP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a small protein that is localized to the endoplasmic reticulum (ER) and may play a role in the ER stress response by mediating cell differentiation and apoptosis. Transcription of this gene is regulated by tumor necrosis factor alpha and specificity protein 1 (Sp1). Mutations in this gene may play a role in microcephaly, epilepsy, and diabetes syndrome (MEDS), and a pseudogene of this gene is located on the long arm of chromosome 12. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.14843398
2mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.86363563
3ATP synthesis coupled proton transport (GO:0015986)6.81341384
4energy coupled proton transport, down electrochemical gradient (GO:0015985)6.81341384
5respiratory electron transport chain (GO:0022904)5.86472226
6electron transport chain (GO:0022900)5.72992076
7protein neddylation (GO:0045116)5.01128153
8protein complex biogenesis (GO:0070271)4.79131540
9GTP biosynthetic process (GO:0006183)4.34533271
10chaperone-mediated protein transport (GO:0072321)4.34365834
11NADH dehydrogenase complex assembly (GO:0010257)4.28667580
12mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.28667580
13mitochondrial respiratory chain complex I assembly (GO:0032981)4.28667580
14ribosomal small subunit biogenesis (GO:0042274)4.25008417
15mitochondrial respiratory chain complex assembly (GO:0033108)4.18998947
16establishment of protein localization to mitochondrial membrane (GO:0090151)4.10858608
17signal peptide processing (GO:0006465)4.04094990
18cotranslational protein targeting to membrane (GO:0006613)3.97304799
19water-soluble vitamin biosynthetic process (GO:0042364)3.91790133
20SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.90090223
21protein targeting to ER (GO:0045047)3.87859485
22hydrogen ion transmembrane transport (GO:1902600)3.80446820
23respiratory chain complex IV assembly (GO:0008535)3.79609717
24regulation of meiosis I (GO:0060631)3.74930812
25protein localization to endoplasmic reticulum (GO:0070972)3.74652753
26cytochrome complex assembly (GO:0017004)3.71408848
27establishment of protein localization to endoplasmic reticulum (GO:0072599)3.66545306
28viral transcription (GO:0019083)3.59900742
29CENP-A containing nucleosome assembly (GO:0034080)3.57395540
30proteasome assembly (GO:0043248)3.54353944
31platelet dense granule organization (GO:0060155)3.53976516
32regulation of mitochondrial translation (GO:0070129)3.52974687
33purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.43985445
34cellular ketone body metabolic process (GO:0046950)3.43488323
35UTP biosynthetic process (GO:0006228)3.43458446
36proton transport (GO:0015992)3.43365997
37ketone body metabolic process (GO:1902224)3.43048218
38chromatin remodeling at centromere (GO:0031055)3.41626975
39ribosomal small subunit assembly (GO:0000028)3.41449170
40regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.39113441
41guanosine-containing compound biosynthetic process (GO:1901070)3.37602362
42translational termination (GO:0006415)3.37347753
43DNA double-strand break processing (GO:0000729)3.36822648
44purine nucleoside triphosphate biosynthetic process (GO:0009145)3.36412858
45inner mitochondrial membrane organization (GO:0007007)3.34870822
46hydrogen transport (GO:0006818)3.32040183
47termination of RNA polymerase III transcription (GO:0006386)3.28138775
48transcription elongation from RNA polymerase III promoter (GO:0006385)3.28138775
49cullin deneddylation (GO:0010388)3.25155195
50anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.20885883
51ATP biosynthetic process (GO:0006754)3.18114638
52protein targeting to mitochondrion (GO:0006626)3.13147153
53exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.06864208
54antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.05404296
55rRNA modification (GO:0000154)3.04647721
56dopamine transport (GO:0015872)3.03363571
57establishment of protein localization to mitochondrion (GO:0072655)3.03330032
58synapsis (GO:0007129)3.03322186
59histone exchange (GO:0043486)2.98978103
60regulation of mitotic spindle checkpoint (GO:1903504)2.97625645
61regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.97625645
62nucleoside diphosphate phosphorylation (GO:0006165)2.96107739
63positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.94489471
64regulation of cellular amino acid metabolic process (GO:0006521)2.94403639
65translation (GO:0006412)2.93522487
66organelle disassembly (GO:1903008)2.91720928
67deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.91675227
68antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.91190749
69GDP-mannose metabolic process (GO:0019673)2.89424813
70ribonucleoside triphosphate biosynthetic process (GO:0009201)2.89225035
71energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.88875164
72ATP hydrolysis coupled proton transport (GO:0015991)2.88875164
73viral life cycle (GO:0019058)2.86145129
74protein localization to mitochondrion (GO:0070585)2.85763830
75protein deneddylation (GO:0000338)2.84738140
76postreplication repair (GO:0006301)2.83461117
77protein K6-linked ubiquitination (GO:0085020)2.83226219
78mannosylation (GO:0097502)2.81611956
79ribosome assembly (GO:0042255)2.81513278
807-methylguanosine mRNA capping (GO:0006370)2.81190847
817-methylguanosine RNA capping (GO:0009452)2.80386382
82RNA capping (GO:0036260)2.80386382
83positive regulation of ligase activity (GO:0051351)2.80226900
84DNA catabolic process, exonucleolytic (GO:0000738)2.79721284
85cellular protein complex disassembly (GO:0043624)2.79652825
86CTP metabolic process (GO:0046036)2.78180659
87CTP biosynthetic process (GO:0006241)2.78180659
88negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.77244471
89regulation of hexokinase activity (GO:1903299)2.76987070
90regulation of glucokinase activity (GO:0033131)2.76987070
91lactate metabolic process (GO:0006089)2.76504268
92pteridine-containing compound biosynthetic process (GO:0042559)2.76426318
93anterograde synaptic vesicle transport (GO:0048490)2.76374985
94negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.75523514
95rRNA methylation (GO:0031167)2.73880447
96inositol phosphate catabolic process (GO:0071545)2.73290351
97ribonucleoprotein complex disassembly (GO:0032988)2.70232913
98piRNA metabolic process (GO:0034587)2.69870023
99UTP metabolic process (GO:0046051)2.69344539
100peptidyl-histidine modification (GO:0018202)2.69057721
101ribosomal large subunit biogenesis (GO:0042273)2.68900508
1022-deoxyribonucleotide biosynthetic process (GO:0009265)2.67854088
103deoxyribose phosphate biosynthetic process (GO:0046385)2.67854088
104signal transduction involved in cell cycle checkpoint (GO:0072395)2.67508258
105nucleotide transmembrane transport (GO:1901679)2.67373237
106transcription elongation from RNA polymerase I promoter (GO:0006362)2.67062101
107translational elongation (GO:0006414)2.66750060
108histone mRNA metabolic process (GO:0008334)2.66474919
109protein K11-linked ubiquitination (GO:0070979)2.65714208
110DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.65011651
111RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.64245207
112tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.64245207
113maturation of 5.8S rRNA (GO:0000460)2.63384271
114iron-sulfur cluster assembly (GO:0016226)2.62406262
115metallo-sulfur cluster assembly (GO:0031163)2.62406262
116inositol phosphate dephosphorylation (GO:0046855)2.61295508
117phosphorylated carbohydrate dephosphorylation (GO:0046838)2.61295508
118L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.61152329
119nucleoside triphosphate biosynthetic process (GO:0009142)2.60198501
120regulation of ubiquitin-protein transferase activity (GO:0051438)2.59190502
121protein localization to cilium (GO:0061512)2.58080657
122intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.57011263
123signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.57011263
124presynaptic membrane assembly (GO:0097105)2.56795627
125DNA deamination (GO:0045006)2.56499447
126signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.55881919
127signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.55881919
128signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.55881919
129intracellular protein transmembrane import (GO:0044743)2.54832960
130positive regulation of mitochondrial fission (GO:0090141)2.54227905
131protein targeting to membrane (GO:0006612)2.52565963
132protein-cofactor linkage (GO:0018065)2.52076000
133phagosome maturation (GO:0090382)2.52005042
134antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.51393370
135cellular respiration (GO:0045333)2.51237973
136C-terminal protein lipidation (GO:0006501)2.51099769
137regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.50480940
138dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.50354791
139negative regulation of ligase activity (GO:0051352)2.49612589
140negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.49612589
141neutrophil activation involved in immune response (GO:0002283)2.48979451
142pseudouridine synthesis (GO:0001522)2.48962475
143positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.46615572
144nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.44066672
145maturation of SSU-rRNA (GO:0030490)2.42688980
146dopamine biosynthetic process (GO:0042416)2.42088580
147regulation of cellular amine metabolic process (GO:0033238)2.41988353
148signal transduction involved in DNA damage checkpoint (GO:0072422)2.41110159
149signal transduction involved in DNA integrity checkpoint (GO:0072401)2.41110159
150oxidative phosphorylation (GO:0006119)2.38863255

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.20711498
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.78761662
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.57794467
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.26040129
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.89477548
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.81456604
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.72726097
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.72384534
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.63805711
10VDR_22108803_ChIP-Seq_LS180_Human2.54547719
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.52407711
12BMI1_23680149_ChIP-Seq_NPCS_Mouse2.45789257
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.41659307
14TAF15_26573619_Chip-Seq_HEK293_Human2.38006612
15PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.37313868
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.26682699
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.21840322
18ELK1_19687146_ChIP-ChIP_HELA_Human2.21477336
19GBX2_23144817_ChIP-Seq_PC3_Human2.20346629
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.10152358
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.07455303
22E2F4_17652178_ChIP-ChIP_JURKAT_Human2.01024786
23ZNF274_21170338_ChIP-Seq_K562_Hela1.97534137
24BP1_19119308_ChIP-ChIP_Hs578T_Human1.97472840
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.93937667
26ETS1_20019798_ChIP-Seq_JURKAT_Human1.89528787
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.88579056
28ELF1_17652178_ChIP-ChIP_JURKAT_Human1.86959647
29EZH2_22144423_ChIP-Seq_EOC_Human1.86845218
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.84301371
31* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.83946634
32PADI4_21655091_ChIP-ChIP_MCF-7_Human1.82611169
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.80477546
34FUS_26573619_Chip-Seq_HEK293_Human1.78965777
35FOXP3_21729870_ChIP-Seq_TREG_Human1.78808713
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.76018155
37IGF1R_20145208_ChIP-Seq_DFB_Human1.64072946
38SRF_21415370_ChIP-Seq_HL-1_Mouse1.63950240
39HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.61656626
40* ELK1_22589737_ChIP-Seq_MCF10A_Human1.59987857
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.58311018
42MYC_18940864_ChIP-ChIP_HL60_Human1.54333292
43VDR_23849224_ChIP-Seq_CD4+_Human1.53599330
44CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.52347674
45* P300_19829295_ChIP-Seq_ESCs_Human1.50395652
46ER_23166858_ChIP-Seq_MCF-7_Human1.49962444
47FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.49510627
48EWS_26573619_Chip-Seq_HEK293_Human1.48991197
49EZH2_27304074_Chip-Seq_ESCs_Mouse1.48365530
50DCP1A_22483619_ChIP-Seq_HELA_Human1.48164483
51RNF2_27304074_Chip-Seq_NSC_Mouse1.43320942
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39641356
53JARID2_20064375_ChIP-Seq_MESCs_Mouse1.38844020
54RBPJ_22232070_ChIP-Seq_NCS_Mouse1.38079447
55* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.38057612
56SALL1_21062744_ChIP-ChIP_HESCs_Human1.37428023
57GABP_19822575_ChIP-Seq_HepG2_Human1.34159204
58SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.33161797
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.33069142
60* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32472134
61MYC_19030024_ChIP-ChIP_MESCs_Mouse1.31219288
62EED_16625203_ChIP-ChIP_MESCs_Mouse1.30598701
63HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.30579867
64FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.28258767
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.27179092
66RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.26678968
67MYC_18555785_ChIP-Seq_MESCs_Mouse1.26190365
68PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.25432223
69SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.24099495
70SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.23048764
71SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.21683032
72HTT_18923047_ChIP-ChIP_STHdh_Human1.20238720
73BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.19388643
74TTF2_22483619_ChIP-Seq_HELA_Human1.19175771
75ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.18659634
76EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17714381
77JUN_21703547_ChIP-Seq_K562_Human1.17643479
78SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.17460280
79TP53_22573176_ChIP-Seq_HFKS_Human1.16045615
80OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15471178
81STAT3_18555785_Chip-Seq_ESCs_Mouse1.15095979
82NANOG_18555785_Chip-Seq_ESCs_Mouse1.14818001
83NANOG_19829295_ChIP-Seq_ESCs_Human1.13950477
84SOX2_19829295_ChIP-Seq_ESCs_Human1.13950477
85SUZ12_18555785_Chip-Seq_ESCs_Mouse1.13313923
86PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13171746
87P53_22387025_ChIP-Seq_ESCs_Mouse1.12592759
88SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12519999
89SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12381856
90NELFA_20434984_ChIP-Seq_ESCs_Mouse1.10089030
91YY1_21170310_ChIP-Seq_MESCs_Mouse1.09487921
92NMYC_18555785_Chip-Seq_ESCs_Mouse1.08910682
93PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.08352269
94CRX_20693478_ChIP-Seq_RETINA_Mouse1.07586659
95E2F1_18555785_ChIP-Seq_MESCs_Mouse1.07566038
96EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07374179
97AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07107582
98YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06581117
99* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05924905
100MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05594700
101JARID2_20075857_ChIP-Seq_MESCs_Mouse1.05392832
102TRIM28_21343339_ChIP-Seq_HEK293_Human1.05001183
103CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.04403270
104E2F1_18555785_Chip-Seq_ESCs_Mouse1.04079796
105EZH2_27294783_Chip-Seq_NPCs_Mouse1.04023118
106* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03891882
107CBP_20019798_ChIP-Seq_JUKART_Human1.03724145
108IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03724145
109* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.03705431
110THAP11_20581084_ChIP-Seq_MESCs_Mouse1.03634953
111AR_21909140_ChIP-Seq_LNCAP_Human1.03630755
112P300_18555785_Chip-Seq_ESCs_Mouse1.03472525
113POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03448525
114NFE2_27457419_Chip-Seq_LIVER_Mouse1.03039305
115SOX2_18555785_Chip-Seq_ESCs_Mouse1.02667971
116FOXA1_25329375_ChIP-Seq_VCAP_Human1.02566525
117FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02566525
118CMYC_18555785_Chip-Seq_ESCs_Mouse1.02526274
119TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02253903
120EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01704372
121NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.01565494
122EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.00926604
123KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.00845781
124MYCN_18555785_ChIP-Seq_MESCs_Mouse1.00188127
125AR_21572438_ChIP-Seq_LNCaP_Human0.99096441
126TAL1_26923725_Chip-Seq_HPCs_Mouse0.97563871
127CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96341303
128WT1_19549856_ChIP-ChIP_CCG9911_Human0.94569474
129GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94422391
130IRF1_19129219_ChIP-ChIP_H3396_Human0.94213917
131SMAD1_18555785_Chip-Seq_ESCs_Mouse0.93967675
132RUNX1_27457419_Chip-Seq_LIVER_Mouse0.93312581
133KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93097858
134MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.93060716
135MYC_18358816_ChIP-ChIP_MESCs_Mouse0.92898057
136* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92149624
137POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.91868316
138FOXA1_21572438_ChIP-Seq_LNCaP_Human0.91560586
139AR_20517297_ChIP-Seq_VCAP_Human0.91503202
140NRF2_20460467_ChIP-Seq_MEFs_Mouse0.91013509
141CDX2_22108803_ChIP-Seq_LS180_Human0.90603873

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.39667095
2MP0003880_abnormal_central_pattern3.85686329
3MP0002163_abnormal_gland_morphology2.97559489
4MP0001529_abnormal_vocalization2.95885666
5MP0003195_calcinosis2.90422845
6MP0008058_abnormal_DNA_repair2.90177636
7MP0003718_maternal_effect2.76842068
8MP0004270_analgesia2.75282386
9MP0006276_abnormal_autonomic_nervous2.71516824
10MP0001905_abnormal_dopamine_level2.60895101
11MP0002822_catalepsy2.54583449
12MP0010386_abnormal_urinary_bladder2.43075885
13MP0008877_abnormal_DNA_methylation2.42186582
14MP0003806_abnormal_nucleotide_metabolis2.32417626
15MP0003136_yellow_coat_color2.31286867
16MP0001188_hyperpigmentation2.26585307
17MP0005379_endocrine/exocrine_gland_phen2.25881520
18MP0000372_irregular_coat_pigmentation2.22632672
19MP0005408_hypopigmentation2.20121361
20MP0001986_abnormal_taste_sensitivity2.11553560
21MP0005075_abnormal_melanosome_morpholog2.07354825
22MP0002638_abnormal_pupillary_reflex2.02948447
23MP0006054_spinal_hemorrhage1.95956159
24MP0008057_abnormal_DNA_replication1.95547120
25MP0002736_abnormal_nociception_after1.93422252
26MP0001984_abnormal_olfaction1.88045995
27MP0002876_abnormal_thyroid_physiology1.86853685
28MP0010094_abnormal_chromosome_stability1.85986274
29MP0003786_premature_aging1.83426217
30MP0002735_abnormal_chemical_nociception1.83068788
31MP0001968_abnormal_touch/_nociception1.80567101
32MP0004957_abnormal_blastocyst_morpholog1.78439404
33MP0005171_absent_coat_pigmentation1.76290679
34MP0005645_abnormal_hypothalamus_physiol1.75251962
35MP0002148_abnormal_hypersensitivity_rea1.74071677
36MP0002139_abnormal_hepatobiliary_system1.67334415
37MP0003724_increased_susceptibility_to1.66786424
38MP0002734_abnormal_mechanical_nocicepti1.64261015
39MP0002751_abnormal_autonomic_nervous1.64082950
40MP0004147_increased_porphyrin_level1.63591144
41MP0004215_abnormal_myocardial_fiber1.61388751
42MP0004142_abnormal_muscle_tone1.59765861
43MP0009250_abnormal_appendicular_skeleto1.53659984
44MP0009780_abnormal_chondrocyte_physiolo1.53650723
45MP0002272_abnormal_nervous_system1.52869551
46MP0002090_abnormal_vision1.52790300
47MP0001764_abnormal_homeostasis1.45777376
48MP0003693_abnormal_embryo_hatching1.45709217
49MP0005409_darkened_coat_color1.45494106
50MP0003122_maternal_imprinting1.42090636
51MP0005332_abnormal_amino_acid1.41779486
52MP0004742_abnormal_vestibular_system1.40775713
53MP0010234_abnormal_vibrissa_follicle1.39429965
54MP0003011_delayed_dark_adaptation1.38240169
55MP0003950_abnormal_plasma_membrane1.37763430
56MP0006072_abnormal_retinal_apoptosis1.34050332
57MP0004134_abnormal_chest_morphology1.33795833
58MP0008932_abnormal_embryonic_tissue1.33790514
59MP0002095_abnormal_skin_pigmentation1.32387017
60MP0009745_abnormal_behavioral_response1.32151738
61MP0005551_abnormal_eye_electrophysiolog1.31906459
62MP0002277_abnormal_respiratory_mucosa1.30650864
63MP0005174_abnormal_tail_pigmentation1.29422793
64MP0002064_seizures1.27711464
65MP0001542_abnormal_bone_strength1.27361905
66MP0002160_abnormal_reproductive_system1.26984101
67MP0002234_abnormal_pharynx_morphology1.26979689
68MP0008789_abnormal_olfactory_epithelium1.26205987
69MP0009046_muscle_twitch1.25966340
70MP0002067_abnormal_sensory_capabilities1.24308400
71MP0005084_abnormal_gallbladder_morpholo1.23103093
72MP0001970_abnormal_pain_threshold1.21285359
73MP0003283_abnormal_digestive_organ1.20945643
74MP0005386_behavior/neurological_phenoty1.18932755
75MP0004924_abnormal_behavior1.18932755
76MP0001963_abnormal_hearing_physiology1.18456394
77MP0001501_abnormal_sleep_pattern1.17833181
78MP0005646_abnormal_pituitary_gland1.17227996
79MP0002210_abnormal_sex_determination1.15078250
80MP0002572_abnormal_emotion/affect_behav1.14986256
81MP0002909_abnormal_adrenal_gland1.13163806
82MP0005187_abnormal_penis_morphology1.12468013
83MP0008260_abnormal_autophagy1.10525961
84MP0002938_white_spotting1.10102757
85MP0000026_abnormal_inner_ear1.09696983
86MP0009785_altered_susceptibility_to1.09302940
87MP0003252_abnormal_bile_duct1.07470198
88MP0000358_abnormal_cell_content/1.07429621
89MP0008875_abnormal_xenobiotic_pharmacok1.07148250
90MP0001324_abnormal_eye_pigmentation1.06772424
91MP0003077_abnormal_cell_cycle1.06058994
92MP0000631_abnormal_neuroendocrine_gland1.05964883
93MP0003878_abnormal_ear_physiology1.05777138
94MP0005377_hearing/vestibular/ear_phenot1.05777138
95MP0001929_abnormal_gametogenesis1.03280639
96MP0003890_abnormal_embryonic-extraembry1.03116892
97MP0002733_abnormal_thermal_nociception1.03034233
98MP0002009_preneoplasia1.02483455
99MP0009697_abnormal_copulation1.01963156
100MP0000653_abnormal_sex_gland1.01259464
101MP0002933_joint_inflammation1.01059329
102MP0003646_muscle_fatigue1.00289933
103MP0005499_abnormal_olfactory_system1.00174608
104MP0005394_taste/olfaction_phenotype1.00174608
105MP0006292_abnormal_olfactory_placode1.00055936
106MP0001486_abnormal_startle_reflex0.99923702
107MP0001440_abnormal_grooming_behavior0.99093048
108MP0005423_abnormal_somatic_nervous0.98714546
109MP0008007_abnormal_cellular_replicative0.98346653
110MP0005389_reproductive_system_phenotype0.98050667
111MP0000049_abnormal_middle_ear0.97462989
112MP0000538_abnormal_urinary_bladder0.96629539
113MP0003186_abnormal_redox_activity0.95933029
114MP0003121_genomic_imprinting0.95760656
115MP0005395_other_phenotype0.94928982
116MP0003635_abnormal_synaptic_transmissio0.94711045
117MP0000013_abnormal_adipose_tissue0.94295097
118MP0003567_abnormal_fetal_cardiomyocyte0.93972961
119MP0001664_abnormal_digestion0.91981537
120MP0002282_abnormal_trachea_morphology0.91873958
121MP0001145_abnormal_male_reproductive0.91720876
122MP0002184_abnormal_innervation0.90920894
123MP0003111_abnormal_nucleus_morphology0.89787576
124MP0003941_abnormal_skin_development0.89593012
125MP0000778_abnormal_nervous_system0.89226503
126MP0002102_abnormal_ear_morphology0.89012675
127MP0000427_abnormal_hair_cycle0.88948877
128MP0005085_abnormal_gallbladder_physiolo0.88025178
129MP0005503_abnormal_tendon_morphology0.87286158
130MP0000762_abnormal_tongue_morphology0.86712202
131MP0001485_abnormal_pinna_reflex0.86534232
132MP0002557_abnormal_social/conspecific_i0.86410750
133MP0003315_abnormal_perineum_morphology0.85840750
134MP0004043_abnormal_pH_regulation0.85484940
135MP0005410_abnormal_fertilization0.84062286
136MP0004381_abnormal_hair_follicle0.83891720
137MP0002837_dystrophic_cardiac_calcinosis0.83854174
138MP0002063_abnormal_learning/memory/cond0.82934117
139MP0001293_anophthalmia0.82397676
140MP0000920_abnormal_myelination0.81528634
141MP0000647_abnormal_sebaceous_gland0.80021262
142MP0001756_abnormal_urination0.79826255
143MP0000015_abnormal_ear_pigmentation0.79611295
144MP0000749_muscle_degeneration0.79555024
145MP0005636_abnormal_mineral_homeostasis0.79265834
146MP0006035_abnormal_mitochondrial_morpho0.79237645
147MP0000681_abnormal_thyroid_gland0.78104169
148MP0001944_abnormal_pancreas_morphology0.78080015
149MP0004782_abnormal_surfactant_physiolog0.77683239
150MP0005164_abnormal_response_to0.76172595
151MP0010368_abnormal_lymphatic_system0.75951144
152MP0002132_abnormal_respiratory_system0.75334308
153MP0005000_abnormal_immune_tolerance0.75175978
154MP0005671_abnormal_response_to0.74674439
155MP0002233_abnormal_nose_morphology0.74443592
156MP0001835_abnormal_antigen_presentation0.74096071
157MP0002295_abnormal_pulmonary_circulatio0.72430860
158MP0000462_abnormal_digestive_system0.69002194
159MP0001727_abnormal_embryo_implantation0.68956908
160MP0006036_abnormal_mitochondrial_physio0.68688985
161MP0000163_abnormal_cartilage_morphology0.68262134
162MP0003937_abnormal_limbs/digits/tail_de0.67966859
163MP0005253_abnormal_eye_physiology0.67771580
164MP0002177_abnormal_outer_ear0.66391675
165MP0005220_abnormal_exocrine_pancreas0.65039250

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.10622225
2Abnormal mitochondria in muscle tissue (HP:0008316)5.40468800
3Mitochondrial inheritance (HP:0001427)5.38122142
4Progressive macrocephaly (HP:0004481)5.17286614
5Increased hepatocellular lipid droplets (HP:0006565)4.69034288
6Acute encephalopathy (HP:0006846)4.63606805
7Increased CSF lactate (HP:0002490)4.35086487
8Renal Fanconi syndrome (HP:0001994)4.07296705
9Hepatocellular necrosis (HP:0001404)4.05081087
10Methylmalonic acidemia (HP:0002912)4.03168372
11Lipid accumulation in hepatocytes (HP:0006561)4.02757999
12Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.91299702
13Irregular epiphyses (HP:0010582)3.88568851
14Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.45552611
15Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.34517968
16Hepatic necrosis (HP:0002605)3.32488810
17Exertional dyspnea (HP:0002875)3.19452592
18Optic disc pallor (HP:0000543)3.15323278
19Hypoglycemic coma (HP:0001325)3.11877972
20Methylmalonic aciduria (HP:0012120)3.11330519
21Hypothermia (HP:0002045)3.08019753
223-Methylglutaconic aciduria (HP:0003535)3.03755260
23Exercise intolerance (HP:0003546)2.97869770
24Epiphyseal dysplasia (HP:0002656)2.91454686
25Respiratory failure (HP:0002878)2.91401148
26Genu varum (HP:0002970)2.88845011
27Abnormality of vitamin B metabolism (HP:0004340)2.87520570
28Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.86614916
29Decreased activity of mitochondrial respiratory chain (HP:0008972)2.86614916
30Increased intramyocellular lipid droplets (HP:0012240)2.85255697
31Generalized aminoaciduria (HP:0002909)2.78392671
32Abnormality of aromatic amino acid family metabolism (HP:0004338)2.76541161
33Medial flaring of the eyebrow (HP:0010747)2.73549017
34Parakeratosis (HP:0001036)2.68659085
35Abnormality of renal resorption (HP:0011038)2.67138441
36Leukodystrophy (HP:0002415)2.67005027
37Abnormal pancreas size (HP:0012094)2.66902341
38Hyperinsulinemic hypoglycemia (HP:0000825)2.61502971
39Congenital, generalized hypertrichosis (HP:0004540)2.59021433
40Renal cortical cysts (HP:0000803)2.58616879
41Respiratory difficulties (HP:0002880)2.56162856
42Cerebral edema (HP:0002181)2.54454877
43Increased serum lactate (HP:0002151)2.52086074
44Abnormality of cells of the erythroid lineage (HP:0012130)2.51586850
45Lactic acidosis (HP:0003128)2.51327111
46Aplasia/Hypoplasia of the fovea (HP:0008060)2.50535061
47Hypoplasia of the fovea (HP:0007750)2.50535061
48Abnormality of the vitamin B12 metabolism (HP:0004341)2.45852419
49Metaphyseal dysplasia (HP:0100255)2.44434074
50Ketoacidosis (HP:0001993)2.42859610
51Abnormality of methionine metabolism (HP:0010901)2.41737283
52Molar tooth sign on MRI (HP:0002419)2.38063281
53Abnormality of midbrain morphology (HP:0002418)2.38063281
54Abnormality of the fovea (HP:0000493)2.38010790
55Short femoral neck (HP:0100864)2.35873114
56Gait imbalance (HP:0002141)2.35372297
57Congenital primary aphakia (HP:0007707)2.33084641
58Cupped ribs (HP:0000887)2.32576767
59Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.32110383
60Degeneration of anterior horn cells (HP:0002398)2.30977683
61Abnormality of the anterior horn cell (HP:0006802)2.30977683
62Flat capital femoral epiphysis (HP:0003370)2.30876296
63Type I transferrin isoform profile (HP:0003642)2.27349574
64Long foot (HP:0001833)2.27139215
65Pancreatic cysts (HP:0001737)2.26045428
66Hyperglycinemia (HP:0002154)2.25769379
67Congenital ichthyosiform erythroderma (HP:0007431)2.24124343
68Nephrogenic diabetes insipidus (HP:0009806)2.23396347
69Hypoglycemic seizures (HP:0002173)2.23153611
70Abnormal number of erythroid precursors (HP:0012131)2.21804347
71Lethargy (HP:0001254)2.20658103
72Increased serum pyruvate (HP:0003542)2.18159345
73Abnormality of glycolysis (HP:0004366)2.18159345
74Increased muscle lipid content (HP:0009058)2.17460898
75Abnormality of aspartate family amino acid metabolism (HP:0010899)2.17417086
76Reticulocytopenia (HP:0001896)2.16822909
77Aplasia/Hypoplasia of the tibia (HP:0005772)2.12645129
78Diastasis recti (HP:0001540)2.11051178
79Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.10044283
80Abnormality of femoral epiphyses (HP:0006499)2.10044283
81Neoplasm of the adrenal gland (HP:0100631)2.09827789
82Short tibia (HP:0005736)2.08974050
83Abnormality of the epiphysis of the femoral head (HP:0010574)2.08037329
84Abnormality of the renal cortex (HP:0011035)2.07938584
85Abnormality of the femoral head (HP:0003368)2.07713018
86Poor suck (HP:0002033)2.07191190
87Abnormality of the labia minora (HP:0012880)2.06927166
88X-linked dominant inheritance (HP:0001423)2.06679781
89Poor coordination (HP:0002370)2.05608866
90True hermaphroditism (HP:0010459)2.04085469
91Neuroendocrine neoplasm (HP:0100634)2.04074449
92Megaloblastic anemia (HP:0001889)2.03645024
93Macrocytic anemia (HP:0001972)2.02528929
94Abnormality of vitamin metabolism (HP:0100508)2.02261896
95Delayed epiphyseal ossification (HP:0002663)2.01729479
96Intestinal atresia (HP:0011100)2.00153247
97Neoplasm of the adrenal cortex (HP:0100641)1.99154766
98Abnormality of macular pigmentation (HP:0008002)1.98311705
99Hepatoblastoma (HP:0002884)1.98285989
100Retinal dysplasia (HP:0007973)1.96681134
101Dicarboxylic aciduria (HP:0003215)1.95602758
102Abnormality of dicarboxylic acid metabolism (HP:0010995)1.95602758
103Hyperphosphaturia (HP:0003109)1.94447059
104Small epiphyses (HP:0010585)1.90733864
105Nephronophthisis (HP:0000090)1.90029081
106Pancreatic fibrosis (HP:0100732)1.89961541
107Abnormal hair whorl (HP:0010721)1.89303936
108Pancreatic islet-cell hyperplasia (HP:0004510)1.89120284
109Abnormal pupillary function (HP:0007686)1.89084773
110Median cleft lip (HP:0000161)1.87092264
111Vaginal atresia (HP:0000148)1.86954767
112Abnormal tarsal ossification (HP:0008369)1.86403334
113Congenital sensorineural hearing impairment (HP:0008527)1.85748210
114CNS demyelination (HP:0007305)1.82707044
115Genital tract atresia (HP:0001827)1.82642279
116Aplasia/hypoplasia of the uterus (HP:0008684)1.81746632
117Large for gestational age (HP:0001520)1.81653373
118Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.80283984
119Abnormal protein N-linked glycosylation (HP:0012347)1.80283984
120Abnormal protein glycosylation (HP:0012346)1.80283984
121Abnormal glycosylation (HP:0012345)1.80283984
122Pheochromocytoma (HP:0002666)1.80112853
123Abnormality of the vertebral endplates (HP:0005106)1.79932522
124Patchy hypopigmentation of hair (HP:0011365)1.79826196
125Proximal tubulopathy (HP:0000114)1.79726508
126Metaphyseal irregularity (HP:0003025)1.78661721
127Hypokinesia (HP:0002375)1.78539544
128Glycosuria (HP:0003076)1.78310651
129Abnormality of urine glucose concentration (HP:0011016)1.78310651
130Renal tubular dysfunction (HP:0000124)1.78065981
131Exercise-induced muscle cramps (HP:0003710)1.75385948
132Abnormality of placental membranes (HP:0011409)1.75328579
133Amniotic constriction ring (HP:0009775)1.75328579
134Conjunctival hamartoma (HP:0100780)1.75115594
135Aplastic anemia (HP:0001915)1.74885005
136Abnormality of incisor morphology (HP:0011063)1.74543068
137Pallor (HP:0000980)1.74402202
138Ketosis (HP:0001946)1.73615763
139Vitreoretinal degeneration (HP:0000655)1.71914407
140Reduced antithrombin III activity (HP:0001976)1.71695353
141Sensory axonal neuropathy (HP:0003390)1.71477795
142Abnormality of serum amino acid levels (HP:0003112)1.71210786
143Volvulus (HP:0002580)1.70637693
144Focal motor seizures (HP:0011153)1.69824982
145Limb dystonia (HP:0002451)1.69057451
146Abnormality of carpal bone ossification (HP:0006257)1.68408353
147Supernumerary spleens (HP:0009799)1.67773929
148Muscular hypotonia of the trunk (HP:0008936)1.66851887
149Irregular vertebral endplates (HP:0003301)1.65390447
150Aplasia/Hypoplasia of the sacrum (HP:0008517)1.64795567
151Flattened epiphyses (HP:0003071)1.64484029

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K124.14476650
2STK164.11212542
3CASK3.15064701
4NME13.13679731
5FRK3.00390730
6TRIM282.94167057
7NME22.63896335
8MST42.47153262
9PBK2.19301051
10ACVR1B2.01140880
11MAP4K21.95923114
12BMPR21.95744983
13VRK21.92891267
14PIM21.87570957
15NEK11.83766462
16BCR1.79606524
17MKNK21.79462970
18TNIK1.76869039
19EIF2AK31.75639151
20BMPR1B1.64079658
21PRKG21.63231877
22ADRBK21.63231605
23ARAF1.63214469
24NUAK11.62598137
25GRK71.59733396
26EIF2AK11.57717230
27MYLK1.56929124
28MST1R1.56195936
29ERBB31.55881171
30MKNK11.45607501
31VRK11.44664783
32TTK1.36687572
33IRAK41.36639148
34RIPK41.36629318
35STK391.35506365
36PDK21.34580846
37LIMK11.34535925
38PIK3CA1.33422681
39PLK21.31486986
40SRPK11.29287668
41INSRR1.28830502
42MAP2K71.24692471
43MUSK1.24631190
44CAMK2B1.19535689
45YES11.19151224
46SIK31.17198905
47CAMK2D1.16882167
48CDC71.16396503
49OXSR11.14092411
50CDK81.13795973
51PINK11.11902043
52BRAF1.09376484
53MAPK131.06508157
54STK31.03546161
55BCKDK1.02670939
56PLK11.02645028
57CDK190.99788303
58DYRK20.99658736
59TLK10.97728299
60GRK50.97097209
61CCNB10.92790518
62STK38L0.88294033
63IRAK10.88137236
64TEC0.86149150
65TIE10.85683490
66PHKG20.85273375
67PHKG10.85273375
68BUB10.85156641
69MAP3K140.84788515
70WNK40.84708077
71CSNK1G30.82080997
72IRAK30.81554025
73CSNK1A1L0.74276777
74STK240.73830900
75IRAK20.72464731
76PRKCG0.72352018
77TAF10.72162918
78MAPKAPK50.72007640
79CAMK2A0.71792112
80PRPF4B0.71311069
81EIF2AK20.71002769
82CAMK2G0.70396005
83ADRBK10.70175573
84NEK60.68901352
85PRKCE0.68395799
86TXK0.66796989
87MARK10.66732233
88ZAK0.66701991
89TESK10.65699331
90UHMK10.65479405
91TGFBR10.65397508
92ABL20.63672525
93MAP2K20.63174879
94BRSK10.62495842
95NTRK30.59834999
96ERBB40.59810474
97MINK10.58055102
98PAK30.58025198
99PLK30.56897435
100RPS6KA40.54880683
101CSNK1G10.54686462
102FER0.53508436
103FGFR20.53029010
104WEE10.51870512
105DYRK1A0.51661390
106MAPK150.51448408
107PLK40.50027880
108PNCK0.50009969
109CDK30.49896399
110AURKB0.49576481
111CSNK2A20.49531704
112ATM0.48106865
113PASK0.47901364
114BRSK20.47702777
115DAPK10.46608626
116NLK0.45674167
117PKN10.43673665
118OBSCN0.42673703
119PIK3CG0.40297183
120CSNK2A10.40122824
121LYN0.40092907
122CLK10.39925666
123STK40.39425020
124DAPK30.38664539
125GRK10.37739786
126PRKACA0.36361309
127PRKG10.36123474
128TSSK60.36081314
129CSNK1A10.35950272
130CSNK1G20.35743535
131PRKCD0.35667241
132CHEK20.35387171
133WNK30.34800317
134AURKA0.33225538
135MAP3K40.31454576
136RPS6KA50.30378097
137CDK140.30180137
138CAMKK20.29653953
139MAPK40.29478277
140PRKCI0.29002486

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.40471579
2Parkinsons disease_Homo sapiens_hsa050124.46245620
3Protein export_Homo sapiens_hsa030603.93835073
4Ribosome_Homo sapiens_hsa030103.64177729
5Alzheimers disease_Homo sapiens_hsa050103.54680281
6Proteasome_Homo sapiens_hsa030503.36006245
7Huntingtons disease_Homo sapiens_hsa050163.27942739
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.71144795
9Sulfur metabolism_Homo sapiens_hsa009202.62084183
10RNA polymerase_Homo sapiens_hsa030202.49264162
11Collecting duct acid secretion_Homo sapiens_hsa049662.08668439
12Propanoate metabolism_Homo sapiens_hsa006401.94089796
13Cardiac muscle contraction_Homo sapiens_hsa042601.85175861
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.74704552
15SNARE interactions in vesicular transport_Homo sapiens_hsa041301.71444687
16Vibrio cholerae infection_Homo sapiens_hsa051101.65140534
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.61091564
18Butanoate metabolism_Homo sapiens_hsa006501.54582583
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.46837079
20Rheumatoid arthritis_Homo sapiens_hsa053231.46651518
21Fanconi anemia pathway_Homo sapiens_hsa034601.45915545
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.35600929
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.32935186
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.30991412
25Pyrimidine metabolism_Homo sapiens_hsa002401.27596537
26RNA transport_Homo sapiens_hsa030131.27062868
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.21178433
28Sphingolipid metabolism_Homo sapiens_hsa006001.17478699
29Serotonergic synapse_Homo sapiens_hsa047261.14937613
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.14913815
31Peroxisome_Homo sapiens_hsa041461.11777187
32Pyruvate metabolism_Homo sapiens_hsa006201.11229910
33Graft-versus-host disease_Homo sapiens_hsa053321.07760491
34Nicotine addiction_Homo sapiens_hsa050331.05154140
35One carbon pool by folate_Homo sapiens_hsa006701.03331649
36Selenocompound metabolism_Homo sapiens_hsa004501.00568075
37Base excision repair_Homo sapiens_hsa034100.98948203
38Phagosome_Homo sapiens_hsa041450.97571093
39Arachidonic acid metabolism_Homo sapiens_hsa005900.96013404
40Homologous recombination_Homo sapiens_hsa034400.95136201
41Synaptic vesicle cycle_Homo sapiens_hsa047210.94719159
42Vitamin B6 metabolism_Homo sapiens_hsa007500.93948275
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.90445792
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90276958
45Allograft rejection_Homo sapiens_hsa053300.90093960
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.88518436
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88192684
48Sulfur relay system_Homo sapiens_hsa041220.86825886
49Basal transcription factors_Homo sapiens_hsa030220.86288056
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85414802
51Steroid biosynthesis_Homo sapiens_hsa001000.85058312
52Nucleotide excision repair_Homo sapiens_hsa034200.84602885
53Purine metabolism_Homo sapiens_hsa002300.83798021
54Pentose and glucuronate interconversions_Homo sapiens_hsa000400.83350878
55African trypanosomiasis_Homo sapiens_hsa051430.81819825
56Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.81161595
57Oocyte meiosis_Homo sapiens_hsa041140.79668129
58Autoimmune thyroid disease_Homo sapiens_hsa053200.79108455
59Caffeine metabolism_Homo sapiens_hsa002320.77315307
60Phototransduction_Homo sapiens_hsa047440.76859055
61Type I diabetes mellitus_Homo sapiens_hsa049400.76436735
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.76142386
63Fatty acid metabolism_Homo sapiens_hsa012120.75943169
64Fatty acid elongation_Homo sapiens_hsa000620.75656883
65Ether lipid metabolism_Homo sapiens_hsa005650.75015771
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74471332
67Fatty acid degradation_Homo sapiens_hsa000710.73886869
68Asthma_Homo sapiens_hsa053100.73353464
69Other glycan degradation_Homo sapiens_hsa005110.72405947
70Circadian rhythm_Homo sapiens_hsa047100.72385568
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72024035
72Tryptophan metabolism_Homo sapiens_hsa003800.71914237
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.69443238
74Spliceosome_Homo sapiens_hsa030400.68668518
75Chemical carcinogenesis_Homo sapiens_hsa052040.67384652
76Cell cycle_Homo sapiens_hsa041100.65190410
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65115267
78Taste transduction_Homo sapiens_hsa047420.64804161
79Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.64122833
80Long-term depression_Homo sapiens_hsa047300.63860317
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63482856
82RNA degradation_Homo sapiens_hsa030180.62594236
83Retinol metabolism_Homo sapiens_hsa008300.62195949
84Mismatch repair_Homo sapiens_hsa034300.61458461
85Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60144209
86Maturity onset diabetes of the young_Homo sapiens_hsa049500.58415834
872-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.58102145
88beta-Alanine metabolism_Homo sapiens_hsa004100.57203142
89Carbon metabolism_Homo sapiens_hsa012000.56754110
90Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56530763
91Metabolic pathways_Homo sapiens_hsa011000.55312151
92Nitrogen metabolism_Homo sapiens_hsa009100.55149955
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54343884
94Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53778368
95Regulation of autophagy_Homo sapiens_hsa041400.53009647
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51014446
97Cocaine addiction_Homo sapiens_hsa050300.49473847
98Mineral absorption_Homo sapiens_hsa049780.49465840
99Dopaminergic synapse_Homo sapiens_hsa047280.49375387
100Intestinal immune network for IgA production_Homo sapiens_hsa046720.49347384
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49124700
102Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.48588573
103Linoleic acid metabolism_Homo sapiens_hsa005910.48054195
104Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46779794
105Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45293924
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45266012
107Circadian entrainment_Homo sapiens_hsa047130.44493560
108Morphine addiction_Homo sapiens_hsa050320.44493212
109p53 signaling pathway_Homo sapiens_hsa041150.44342656
110Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44108535
111Arginine and proline metabolism_Homo sapiens_hsa003300.44018514
112N-Glycan biosynthesis_Homo sapiens_hsa005100.42857755
113GABAergic synapse_Homo sapiens_hsa047270.42733566
114Amphetamine addiction_Homo sapiens_hsa050310.42693238
115Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40239639
116Drug metabolism - other enzymes_Homo sapiens_hsa009830.40058222
117Folate biosynthesis_Homo sapiens_hsa007900.37538436
118Legionellosis_Homo sapiens_hsa051340.37408713
119Glutathione metabolism_Homo sapiens_hsa004800.37277563
120DNA replication_Homo sapiens_hsa030300.36464388
121Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.36013218
122Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35860334
123Steroid hormone biosynthesis_Homo sapiens_hsa001400.35044946
124Cholinergic synapse_Homo sapiens_hsa047250.34973718
125Malaria_Homo sapiens_hsa051440.34857444
126Long-term potentiation_Homo sapiens_hsa047200.33821426
127Salivary secretion_Homo sapiens_hsa049700.33091472
128Renin secretion_Homo sapiens_hsa049240.33058770
129Insulin secretion_Homo sapiens_hsa049110.32901880
130Epstein-Barr virus infection_Homo sapiens_hsa051690.32504452
131Tyrosine metabolism_Homo sapiens_hsa003500.32389818
132Pancreatic secretion_Homo sapiens_hsa049720.31847314
133Glutamatergic synapse_Homo sapiens_hsa047240.31613937
134Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30200482
135Hematopoietic cell lineage_Homo sapiens_hsa046400.29646015
136Non-homologous end-joining_Homo sapiens_hsa034500.29459080
137Pertussis_Homo sapiens_hsa051330.28512627
138Vitamin digestion and absorption_Homo sapiens_hsa049770.26551726
139Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26230655
140NOD-like receptor signaling pathway_Homo sapiens_hsa046210.25691217
141mRNA surveillance pathway_Homo sapiens_hsa030150.23918834
142Alcoholism_Homo sapiens_hsa050340.23343429
143Olfactory transduction_Homo sapiens_hsa047400.23123487
144Phenylalanine metabolism_Homo sapiens_hsa003600.22920371
145Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.21808571
146Salmonella infection_Homo sapiens_hsa051320.19354502
147Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.18708343
148Calcium signaling pathway_Homo sapiens_hsa040200.18426766

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »