IER5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is similar to other immediate early response proteins. In the mouse, a similar gene may play an important role in mediating the cellular response to mitogenic signals. Studies in rats found the expression of a similar gene to be increased after waking and sleep deprivation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of vitamin D biosynthetic process (GO:0060556)4.51709770
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.39004442
3regulation of interleukin-12 biosynthetic process (GO:0045075)4.24183724
4response to muramyl dipeptide (GO:0032495)4.21222889
5regulation of B cell receptor signaling pathway (GO:0050855)4.20086165
6positive regulation of gamma-delta T cell activation (GO:0046645)4.06641822
7antigen processing and presentation of endogenous antigen (GO:0019883)4.01120909
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.00441048
9negative regulation of cell killing (GO:0031342)4.00441048
10positive regulation by organism of defense response of other organism involved in symbiotic interact3.98752891
11modulation by symbiont of host immune response (GO:0052553)3.98752891
12positive regulation by symbiont of host defense response (GO:0052509)3.98752891
13modulation by symbiont of host defense response (GO:0052031)3.98752891
14modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.98752891
15modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.98752891
16microglial cell activation (GO:0001774)3.95154261
17regulation of interferon-beta biosynthetic process (GO:0045357)3.91372889
18activation of MAPKKK activity (GO:0000185)3.88667695
19NIK/NF-kappaB signaling (GO:0038061)3.78935082
20macrophage activation involved in immune response (GO:0002281)3.75414313
21T-helper 1 type immune response (GO:0042088)3.74008381
22antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.67666929
23antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.67666929
24CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.65522188
25tolerance induction (GO:0002507)3.59378202
26positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.52718200
27positive thymic T cell selection (GO:0045059)3.44424175
28negative regulation of erythrocyte differentiation (GO:0045647)3.43524448
29regulation of vitamin metabolic process (GO:0030656)3.38418165
30response to protozoan (GO:0001562)3.36933170
31regulation of T-helper 1 cell differentiation (GO:0045625)3.31917687
32positive regulation of chemokine secretion (GO:0090197)3.26344803
33myeloid dendritic cell differentiation (GO:0043011)3.26342115
34positive regulation of antigen processing and presentation (GO:0002579)3.26323768
35cellular extravasation (GO:0045123)3.25934381
36detection of other organism (GO:0098543)3.24725532
37regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.17089894
38defense response to protozoan (GO:0042832)3.16144978
39positive regulation of chemokine biosynthetic process (GO:0045080)3.14914403
40regulation of T cell tolerance induction (GO:0002664)3.14468279
41regulation of gamma-delta T cell differentiation (GO:0045586)3.14410565
42neutrophil activation involved in immune response (GO:0002283)3.14332646
43detection of bacterium (GO:0016045)3.13694422
44cellular response to arsenic-containing substance (GO:0071243)3.13587215
45JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.11264866
46regulation of dendritic cell antigen processing and presentation (GO:0002604)3.10775494
47negative regulation of granulocyte differentiation (GO:0030853)3.09544450
48interferon-gamma-mediated signaling pathway (GO:0060333)3.08125943
49myeloid dendritic cell activation (GO:0001773)3.07702023
50positive regulation of interferon-alpha production (GO:0032727)3.06580704
51mature B cell differentiation (GO:0002335)3.06481062
52negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.05586771
53regulation of gamma-delta T cell activation (GO:0046643)3.04541705
54leukocyte aggregation (GO:0070486)3.01814008
55B cell receptor signaling pathway (GO:0050853)3.00282454
56regulation of podosome assembly (GO:0071801)2.98971387
57response to laminar fluid shear stress (GO:0034616)2.98873102
58regulation of interferon-alpha production (GO:0032647)2.97698970
59immunoglobulin mediated immune response (GO:0016064)2.96808911
60macrophage activation (GO:0042116)2.91963883
61regulation of antigen processing and presentation (GO:0002577)2.91333127
62neutrophil activation (GO:0042119)2.90914096
63granulocyte activation (GO:0036230)2.88696367
64regulation of type I interferon-mediated signaling pathway (GO:0060338)2.87950140
65positive regulation of B cell differentiation (GO:0045579)2.84800561
66negative regulation of T cell mediated immunity (GO:0002710)2.84321934
67negative thymic T cell selection (GO:0045060)2.83733898
68regulation of B cell differentiation (GO:0045577)2.81717364
69regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.78584986
70positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.77581882
71regulation of interleukin-2 biosynthetic process (GO:0045076)2.77192327
72regulation of chemokine biosynthetic process (GO:0045073)2.77174391
73thymic T cell selection (GO:0045061)2.76321979
74dendritic cell differentiation (GO:0097028)2.74900989
75germinal center formation (GO:0002467)2.74891476
76negative regulation of cytokine production involved in immune response (GO:0002719)2.74760382
77detection of molecule of bacterial origin (GO:0032490)2.74171000
78negative T cell selection (GO:0043383)2.73821895
79myeloid cell activation involved in immune response (GO:0002275)2.73488384
80lipopolysaccharide-mediated signaling pathway (GO:0031663)2.73487456
81positive regulation of humoral immune response (GO:0002922)2.73098472
82positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.71012044
83detection of external biotic stimulus (GO:0098581)2.70759519
84positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.70506340
85negative regulation of interleukin-6 production (GO:0032715)2.70402228
86G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.70288255
87positive T cell selection (GO:0043368)2.70231702
88positive regulation of type 2 immune response (GO:0002830)2.70062581
89regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.69452682
90positive regulation of p38MAPK cascade (GO:1900745)2.69345316
91regulation of chronic inflammatory response (GO:0002676)2.69175561
92regulation of T-helper 2 cell differentiation (GO:0045628)2.67840660
93response to peptidoglycan (GO:0032494)2.67122386
94regulation of chemokine secretion (GO:0090196)2.65417163
95positive regulation of interleukin-12 production (GO:0032735)2.64377363
96T cell migration (GO:0072678)2.64154198
97regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.64113814
98regulation of interferon-gamma biosynthetic process (GO:0045072)2.63898187
99response to interleukin-15 (GO:0070672)2.63640558
100positive regulation of cytokine biosynthetic process (GO:0042108)2.62573755
101growth hormone receptor signaling pathway (GO:0060396)2.61889660
102embryonic process involved in female pregnancy (GO:0060136)2.60163878
103I-kappaB phosphorylation (GO:0007252)2.58167885
104interferon-gamma production (GO:0032609)2.57235402
105positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.56537690
106negative regulation of interleukin-12 production (GO:0032695)2.56004909
107positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.55626536
108regulation of tolerance induction (GO:0002643)2.54569498
109myeloid leukocyte activation (GO:0002274)2.54213778
110cellular response to interferon-gamma (GO:0071346)2.54186275
111positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.53557011
112negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.53414812
113B cell mediated immunity (GO:0019724)2.53168338
114negative regulation of toll-like receptor signaling pathway (GO:0034122)2.52878384
115positive regulation of interleukin-2 production (GO:0032743)2.52477575
116regulation of cytokine secretion involved in immune response (GO:0002739)2.52375426
117B cell homeostasis (GO:0001782)2.52189995
118regulation of interleukin-12 production (GO:0032655)2.52055326
119T cell selection (GO:0045058)2.52032252
120cellular response to lipopolysaccharide (GO:0071222)2.51708366
121protein localization to endosome (GO:0036010)2.51666982
122leukocyte cell-cell adhesion (GO:0007159)2.51231754
123regulation of T-helper cell differentiation (GO:0045622)2.51153629
124positive regulation of NF-kappaB import into nucleus (GO:0042346)2.49383903
125respiratory burst (GO:0045730)2.48412614
126response to type I interferon (GO:0034340)2.47546247
127response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.47293859
128response to host (GO:0075136)2.47293859
129response to host defenses (GO:0052200)2.47293859
130cellular response to interleukin-15 (GO:0071350)2.47100868
131germ cell migration (GO:0008354)2.46599572
132regulation of monocyte differentiation (GO:0045655)2.44891303
133cellular response to type I interferon (GO:0071357)2.44114479
134type I interferon signaling pathway (GO:0060337)2.44114479
135positive regulation of tolerance induction (GO:0002645)2.43734895
136response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.43083117
137response to host immune response (GO:0052572)2.43083117
138hepatocyte apoptotic process (GO:0097284)2.40612916
139negative regulation of bone resorption (GO:0045779)2.39696442
140positive regulation of macrophage differentiation (GO:0045651)2.38795678
141negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.38224578
142antigen receptor-mediated signaling pathway (GO:0050851)2.36767103
143natural killer cell differentiation (GO:0001779)2.35903240

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.27955350
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.30404536
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.16632379
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.12006695
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.84015612
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.63676079
7* IRF8_27001747_Chip-Seq_BMDM_Mouse3.24595561
8TP63_17297297_ChIP-ChIP_HaCaT_Human3.20874707
9* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.16900662
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.15056173
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.83758639
12* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.68349678
13* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.61249432
14* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.52576319
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.52059899
16* RUNX_20019798_ChIP-Seq_JUKART_Human2.51534271
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.35381318
18* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.28541298
19STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.27109000
20* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.18225175
21* MAF_26560356_Chip-Seq_TH1_Human2.17742833
22* TCF7_22412390_ChIP-Seq_EML_Mouse2.16235703
23Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.10316753
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.09318929
25STAT4_19710469_ChIP-ChIP_TH1__Mouse2.08471497
26TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.06873130
27* VDR_24763502_ChIP-Seq_THP-1_Human2.00875980
28MYC_22102868_ChIP-Seq_BL_Human1.98785734
29* MYB_26560356_Chip-Seq_TH2_Human1.97816738
30BRD4_27068464_Chip-Seq_AML-cells_Mouse1.97213010
31SCL_19346495_ChIP-Seq_HPC-7_Human1.94898959
32* VDR_21846776_ChIP-Seq_THP-1_Human1.92850738
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.92097116
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.91209618
35* KDM2B_26808549_Chip-Seq_DND41_Human1.85669122
36SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.85112348
37SMAD_19615063_ChIP-ChIP_OVARY_Human1.84955387
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.84784669
39* ELK3_25401928_ChIP-Seq_HUVEC_Human1.78023193
40* MYB_26560356_Chip-Seq_TH1_Human1.69916596
41* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.67184610
42SPI1_23127762_ChIP-Seq_K562_Human1.66735269
43UTX_26944678_Chip-Seq_JUKART_Human1.65972351
44* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.65651963
45* VDR_24787735_ChIP-Seq_THP-1_Human1.64264618
46TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.63884790
47E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.63485112
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.58273167
49* RACK7_27058665_Chip-Seq_MCF-7_Human1.55773805
50TRIM28_21343339_ChIP-Seq_HEK293_Human1.51906544
51* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.47455954
52* SPI1_23547873_ChIP-Seq_NB4_Human1.41316054
53* PU_27001747_Chip-Seq_BMDM_Mouse1.39196086
54NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.33563456
55* KDM2B_26808549_Chip-Seq_JURKAT_Human1.33033137
56RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.31317943
57PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31317889
58ATF3_27146783_Chip-Seq_COLON_Human1.29748453
59CLOCK_20551151_ChIP-Seq_293T_Human1.29682050
60* GATA2_21666600_ChIP-Seq_HMVEC_Human1.28454268
61FOXO3_23340844_ChIP-Seq_DLD1_Human1.27839825
62* GATA3_27048872_Chip-Seq_THYMUS_Human1.27686170
63NCOR1_26117541_ChIP-Seq_K562_Human1.24565185
64IKZF1_21737484_ChIP-ChIP_HCT116_Human1.24512989
65THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.22271603
66* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19975356
67MAF_26560356_Chip-Seq_TH2_Human1.17543622
68PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17095301
69DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15294545
70WT1_19549856_ChIP-ChIP_CCG9911_Human1.14110758
71* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.13882688
72* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.13882688
73FOXM1_23109430_ChIP-Seq_U2OS_Human1.13308074
74SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.13182387
75* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.12593769
76* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11353445
77SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.11294694
78* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.08713460
79* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.06854145
80* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.06684327
81STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05479440
82* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05408977
83* KDM2B_26808549_Chip-Seq_K562_Human1.04738580
84HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04223092
85* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.03641353
86RARG_19884340_ChIP-ChIP_MEFs_Mouse1.03292249
87CJUN_26792858_Chip-Seq_BT549_Human1.01638595
88JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01412566
89CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00980422
90PU.1_20513432_ChIP-Seq_Bcells_Mouse0.99597129
91* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.99232669
92* SA1_27219007_Chip-Seq_ERYTHROID_Human0.99168491
93* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.99156763
94PPAR_26484153_Chip-Seq_NCI-H1993_Human0.98895926
95TP53_22127205_ChIP-Seq_IMR90_Human0.98680517
96BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.98545793
97* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98439895
98* UBF1/2_26484160_Chip-Seq_HMECs_Human0.98012195
99CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97975251
100* GATA2_19941826_ChIP-Seq_K562_Human0.97642028
101ESR2_21235772_ChIP-Seq_MCF-7_Human0.97627928
102SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96361065
103GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95689897
104LXR_22292898_ChIP-Seq_THP-1_Human0.95092391
105TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93631299
106JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93589814
107* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.93452546
108EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.92366035
109NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91855860
110P63_26484246_Chip-Seq_KERATINOCYTES_Human0.91641506
111ESR1_21235772_ChIP-Seq_MCF-7_Human0.91434583
112* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.90639471
113PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90094898
114* GATA1_19941826_ChIP-Seq_K562_Human0.89930478
115STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89214324
116CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86265354
117GATA1_22025678_ChIP-Seq_K562_Human0.84956241
118* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.84507888
119* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.83004494
120ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.82887467
121* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.82500051
122EGR1_19032775_ChIP-ChIP_M12_Human0.82172069

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.19613964
2MP0001835_abnormal_antigen_presentation3.59705455
3MP0004510_myositis3.52124408
4MP0003436_decreased_susceptibility_to2.90493797
5MP0000685_abnormal_immune_system2.82631847
6MP0005387_immune_system_phenotype2.81291096
7MP0001790_abnormal_immune_system2.81291096
8MP0005671_abnormal_response_to2.76582984
9MP0005000_abnormal_immune_tolerance2.73133508
10MP0001800_abnormal_humoral_immune2.69916295
11MP0002452_abnormal_antigen_presenting2.60991596
12MP0003300_gastrointestinal_ulcer2.58132773
13MP0006082_CNS_inflammation2.54141521
14MP0003724_increased_susceptibility_to2.52161249
15MP0002723_abnormal_immune_serum2.42775184
16MP0002148_abnormal_hypersensitivity_rea2.36598384
17MP0002419_abnormal_innate_immunity2.34684347
18MP0009785_altered_susceptibility_to2.28134821
19MP0001819_abnormal_immune_cell2.24233983
20MP0002420_abnormal_adaptive_immunity2.23254474
21MP0002166_altered_tumor_susceptibility2.19524050
22MP0004947_skin_inflammation2.10858457
23MP0005025_abnormal_response_to2.10228775
24MP0005451_abnormal_body_composition2.08838578
25MP0002405_respiratory_system_inflammati1.97156432
26MP0002254_reproductive_system_inflammat1.92069458
27MP0002138_abnormal_hepatobiliary_system1.88220285
28MP0003763_abnormal_thymus_physiology1.82678583
29MP0002006_tumorigenesis1.82308996
30MP0001533_abnormal_skeleton_physiology1.81297377
31MP0001853_heart_inflammation1.80358943
32MP0003828_pulmonary_edema1.78262587
33MP0009840_abnormal_foam_cell1.78008264
34MP0001873_stomach_inflammation1.76901045
35MP0009278_abnormal_bone_marrow1.73468846
36MP0003191_abnormal_cellular_cholesterol1.71416162
37MP0002398_abnormal_bone_marrow1.70647330
38MP0000716_abnormal_immune_system1.70569422
39MP0010155_abnormal_intestine_physiology1.65152409
40MP0005464_abnormal_platelet_physiology1.64822446
41MP0005076_abnormal_cell_differentiation1.64634446
42MP0002933_joint_inflammation1.62293389
43MP0001845_abnormal_inflammatory_respons1.54753469
44MP0001851_eye_inflammation1.52307126
45MP0003091_abnormal_cell_migration1.50547813
46MP0008260_abnormal_autophagy1.49581940
47MP0002998_abnormal_bone_remodeling1.48810499
48MP0005310_abnormal_salivary_gland1.47411344
49MP0003453_abnormal_keratinocyte_physiol1.46419659
50MP0003566_abnormal_cell_adhesion1.43647157
51MP0005058_abnormal_lysosome_morphology1.42500347
52MP0003448_altered_tumor_morphology1.41275574
53MP0009333_abnormal_splenocyte_physiolog1.40728043
54MP0000689_abnormal_spleen_morphology1.39465460
55MP0003279_aneurysm1.38653997
56MP0010352_gastrointestinal_tract_polyps1.37704529
57MP0003075_altered_response_to1.37427969
58MP0002722_abnormal_immune_system1.34898854
59MP0002429_abnormal_blood_cell1.33951259
60MP0000465_gastrointestinal_hemorrhage1.28288087
61MP0000343_altered_response_to1.27230655
62MP0003045_fibrosis1.26499465
63MP0004808_abnormal_hematopoietic_stem1.25380689
64MP0005397_hematopoietic_system_phenotyp1.23954123
65MP0001545_abnormal_hematopoietic_system1.23954123
66MP0002009_preneoplasia1.23805965
67MP0000858_altered_metastatic_potential1.18582189
68MP0003172_abnormal_lysosome_physiology1.17017988
69MP0010234_abnormal_vibrissa_follicle1.16612151
70MP0000767_abnormal_smooth_muscle1.16327310
71MP0000703_abnormal_thymus_morphology1.11323812
72MP0005390_skeleton_phenotype1.09989537
73MP0008469_abnormal_protein_level1.07108082
74MP0005023_abnormal_wound_healing1.05130342
75MP0002332_abnormal_exercise_endurance1.01474193
76MP0005166_decreased_susceptibility_to1.00945558
77MP0003705_abnormal_hypodermis_morpholog0.99685177
78MP0000249_abnormal_blood_vessel0.99147358
79MP0003656_abnormal_erythrocyte_physiolo0.98001246
80MP0009764_decreased_sensitivity_to0.97649325
81MP0008438_abnormal_cutaneous_collagen0.96956112
82MP0008004_abnormal_stomach_pH0.96256285
83MP0002877_abnormal_melanocyte_morpholog0.95660159
84MP0003866_abnormal_defecation0.93222327
85MP0002796_impaired_skin_barrier0.90514582
86MP0002396_abnormal_hematopoietic_system0.90434329
87MP0001879_abnormal_lymphatic_vessel0.90339556
88MP0001958_emphysema0.90249676
89MP0002928_abnormal_bile_duct0.86027071
90MP0005623_abnormal_meninges_morphology0.84811881
91MP0008961_abnormal_basal_metabolism0.83352307
92MP0001216_abnormal_epidermal_layer0.82310302
93MP0005275_abnormal_skin_tensile0.81925826
94MP0005164_abnormal_response_to0.79904881
95MP0003795_abnormal_bone_structure0.79700122
96MP0005167_abnormal_blood-brain_barrier0.78631299
97MP0003221_abnormal_cardiomyocyte_apopto0.78396325
98MP0003183_abnormal_peptide_metabolism0.78321596
99MP0004185_abnormal_adipocyte_glucose0.77966091
100MP0004381_abnormal_hair_follicle0.77658391
101MP0000733_abnormal_muscle_development0.75824236
102MP0009931_abnormal_skin_appearance0.74404626
103MP0001348_abnormal_lacrimal_gland0.73615909
104MP0009763_increased_sensitivity_to0.73476287
105MP0002132_abnormal_respiratory_system0.71386841
106MP0000604_amyloidosis0.71007234
107MP0008007_abnormal_cellular_replicative0.70781315
108MP0004883_abnormal_blood_vessel0.70661983
109MP0002060_abnormal_skin_morphology0.69926848
110MP0005621_abnormal_cell_physiology0.69748855
111MP0001663_abnormal_digestive_system0.68137872
112MP0010307_abnormal_tumor_latency0.67906818
113MP0005501_abnormal_skin_physiology0.66754566
114MP0001542_abnormal_bone_strength0.65436781
115MP0002277_abnormal_respiratory_mucosa0.65436664
116MP0000490_abnormal_crypts_of0.64607442

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.12070423
2Recurrent abscess formation (HP:0002722)4.75030256
3Recurrent bacterial skin infections (HP:0005406)4.43010958
4Hematochezia (HP:0002573)4.20125107
5Elevated erythrocyte sedimentation rate (HP:0003565)3.78485404
6Stomatitis (HP:0010280)3.72492446
7Systemic lupus erythematosus (HP:0002725)3.65982918
8Cerebral aneurysm (HP:0004944)3.65591499
9Myositis (HP:0100614)3.59841591
10Recurrent fungal infections (HP:0002841)3.58713025
11Colitis (HP:0002583)3.56801893
12Mediastinal lymphadenopathy (HP:0100721)3.18950296
13Inflammation of the large intestine (HP:0002037)3.16976247
14Arterial tortuosity (HP:0005116)3.16516146
15Cellulitis (HP:0100658)3.14251342
16Increased IgE level (HP:0003212)3.12142767
17Glomerulonephritis (HP:0000099)3.09977210
18Recurrent skin infections (HP:0001581)3.07884437
19Orchitis (HP:0100796)3.06298568
20Recurrent viral infections (HP:0004429)3.05981560
21Aortic aneurysm (HP:0004942)2.97466858
22Chronic otitis media (HP:0000389)2.97041920
23Myocardial infarction (HP:0001658)2.96385328
24Vascular tortuosity (HP:0004948)2.94365073
25Recurrent gram-negative bacterial infections (HP:0005420)2.94330096
26Gastrointestinal inflammation (HP:0004386)2.94128877
27Interstitial pulmonary disease (HP:0006530)2.93575569
28Spontaneous hematomas (HP:0007420)2.92138897
29Chronic mucocutaneous candidiasis (HP:0002728)2.90673961
30Recurrent cutaneous fungal infections (HP:0011370)2.90673961
31Optic neuritis (HP:0100653)2.83930279
32Retrobulbar optic neuritis (HP:0100654)2.83930279
33Abnormality of glycolipid metabolism (HP:0010969)2.74419428
34Abnormality of liposaccharide metabolism (HP:0010968)2.74419428
35Abnormality of glycosphingolipid metabolism (HP:0004343)2.74419428
36Aortic dissection (HP:0002647)2.72574825
37Abnormality of macrophages (HP:0004311)2.68637344
38Vasculitis (HP:0002633)2.65857741
39Obstructive lung disease (HP:0006536)2.65768422
40Chronic obstructive pulmonary disease (HP:0006510)2.65768422
41Agammaglobulinemia (HP:0004432)2.62120622
42Increased cerebral lipofuscin (HP:0011813)2.61685442
43Arterial thrombosis (HP:0004420)2.61103388
44Abnormality of the nasal mucosa (HP:0000433)2.60687524
45Nasal polyposis (HP:0100582)2.52659739
46IgA deficiency (HP:0002720)2.52054464
47Pulmonary infiltrates (HP:0002113)2.51880633
48Increased density of long bones (HP:0006392)2.47161752
49Mitral valve prolapse (HP:0001634)2.45986827
50Meningitis (HP:0001287)2.45332425
51Emphysema (HP:0002097)2.44540288
52Recurrent bronchitis (HP:0002837)2.43732269
53Gingivitis (HP:0000230)2.36779605
54Increased neuronal autofluorescent lipopigment (HP:0002074)2.35579080
55Dysostosis multiplex (HP:0000943)2.35076148
56Abnormal delayed hypersensitivity skin test (HP:0002963)2.33559027
57Hypertensive crisis (HP:0100735)2.33355774
58Pustule (HP:0200039)2.32361554
59Distal lower limb muscle weakness (HP:0009053)2.29768330
60Chronic diarrhea (HP:0002028)2.29374105
61Restrictive lung disease (HP:0002091)2.27297691
62Peritonitis (HP:0002586)2.26947741
63Autoimmune hemolytic anemia (HP:0001890)2.24731178
64Urticaria (HP:0001025)2.23330578
65Leukocytosis (HP:0001974)2.22931614
66Thick nail (HP:0001805)2.22930463
67Vacuolated lymphocytes (HP:0001922)2.21289405
68Osteolytic defects of the phalanges of the hand (HP:0009771)2.20996861
69Osteolytic defects of the hand bones (HP:0009699)2.20996861
70Petechiae (HP:0000967)2.20967679
71Gastrointestinal stroma tumor (HP:0100723)2.18781224
72Fatigue (HP:0012378)2.18406092
73Osteomyelitis (HP:0002754)2.18264416
74Abnormality of cells of the lymphoid lineage (HP:0012140)2.18041401
75Panhypogammaglobulinemia (HP:0003139)2.17758619
76Axonal loss (HP:0003447)2.15812567
77Dilatation of the ascending aorta (HP:0005111)2.13782781
78Hemoptysis (HP:0002105)2.13615448
79Spondylolisthesis (HP:0003302)2.13485875
80Increased IgM level (HP:0003496)2.13330404
81Deep palmar crease (HP:0006191)2.10909255
82Persistence of primary teeth (HP:0006335)2.09967209
83Syringomyelia (HP:0003396)2.09651229
84Spinal cord lesions (HP:0100561)2.09651229
85Eosinophilia (HP:0001880)2.09122756
86Abnormality of nail color (HP:0100643)2.08372291
87Sparse lateral eyebrow (HP:0005338)2.07834073
88Thrombocytosis (HP:0001894)2.06415267
89Premature rupture of membranes (HP:0001788)2.05478525
90Nephritis (HP:0000123)2.05361519
91Autoimmune thrombocytopenia (HP:0001973)2.03371286
92IgM deficiency (HP:0002850)2.02795510
93Disinhibition (HP:0000734)2.02327273
94Hypergammaglobulinemia (HP:0010702)2.01728169
95Segmental peripheral demyelination/remyelination (HP:0003481)2.00881934
96Gangrene (HP:0100758)2.00583120
97Striae distensae (HP:0001065)1.96496944
98Gastrointestinal infarctions (HP:0005244)1.93100454
99Chronic sinusitis (HP:0011109)1.92403148
100Nuclear cataract (HP:0100018)1.91311915
101Thin bony cortex (HP:0002753)1.91027122
102Abnormal platelet function (HP:0011869)1.90618186
103Impaired platelet aggregation (HP:0003540)1.90618186
104Abnormality of T cell number (HP:0011839)1.90443169
105Chest pain (HP:0100749)1.90094293
106Periodontitis (HP:0000704)1.90001392
107Vertebral compression fractures (HP:0002953)1.89981187
108Encephalitis (HP:0002383)1.89277317
109Viral hepatitis (HP:0006562)1.88447082
110Achilles tendon contracture (HP:0001771)1.88270681
111Polycythemia (HP:0001901)1.87988281
112Loss of speech (HP:0002371)1.87008938
113T lymphocytopenia (HP:0005403)1.86481767
114Arthralgia (HP:0002829)1.85738182
115Increased serum ferritin (HP:0003281)1.85699560
116Keratoconjunctivitis sicca (HP:0001097)1.83344242
117Distal lower limb amyotrophy (HP:0008944)1.82793601
118Abnormality of the pericardium (HP:0001697)1.81510722
119Acrocyanosis (HP:0001063)1.81404272
120Hyperparathyroidism (HP:0000843)1.79634834
121Urethral obstruction (HP:0000796)1.79560839
122Lymphopenia (HP:0001888)1.78398731
123Papilloma (HP:0012740)1.78172617
124Verrucae (HP:0200043)1.78172617
125Polygenic inheritance (HP:0010982)1.77361478
126Protrusio acetabuli (HP:0003179)1.77190809
127Skin ulcer (HP:0200042)1.76963555
128Keratoconjunctivitis (HP:0001096)1.75734839
129Disproportionate tall stature (HP:0001519)1.75460217
130Squamous cell carcinoma (HP:0002860)1.73266835
131Recurrent lower respiratory tract infections (HP:0002783)1.70942818
132Abnormality of T cell physiology (HP:0011840)1.70548737
133Broad face (HP:0000283)1.69483763
134Slow saccadic eye movements (HP:0000514)1.68894474
135Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.66731623
136Recurrent sinusitis (HP:0011108)1.63959512
137Abnormality of the pleura (HP:0002103)1.63813663
138Glomerulopathy (HP:0100820)1.62904261
139Sepsis (HP:0100806)1.62687810

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR24.03532570
2PRPF4B3.88110739
3MAP3K143.43489925
4MAP4K13.25688788
5TBK12.80346814
6TYK22.69291613
7MAPK152.66207108
8RIPK42.65500407
9IRAK32.32494525
10BLK2.25918440
11IKBKB2.24846235
12STK102.09835452
13JAK12.03925349
14SIK12.01936612
15IKBKE1.93650686
16CSF1R1.91897520
17NME21.88913053
18EPHB11.88613048
19JAK31.87486981
20TAOK21.85931960
21IRAK41.85781964
22MAP3K131.73518762
23TXK1.69115109
24CSK1.68875398
25ITK1.64656221
26CHUK1.60871691
27ZAP701.57408031
28AKT31.53511428
29SMG11.53063608
30BMPR21.52103621
31ERN11.48030357
32MAP3K101.44863802
33HCK1.44754748
34FGFR41.30800403
35EPHA31.30634360
36KIT1.26154325
37FES1.25379291
38TRIB31.23470612
39RIPK11.21684895
40MST41.21565225
41TSSK61.20973760
42SIK31.20910361
43RPS6KA41.17114331
44TEC1.16524188
45IRAK21.14154369
46MAP2K31.13821704
47MAP3K31.12818116
48SIK21.11374033
49GRK71.10861233
50MAP3K111.09799183
51FGFR31.09681570
52PAK41.08685687
53LCK1.08395512
54BTK1.08289540
55PTK61.06588573
56NLK1.06011382
57CLK11.05408291
58GRK61.05032385
59LRRK21.03836061
60DDR20.99342937
61SYK0.99337420
62CDC42BPA0.98203223
63NEK90.96841212
64MOS0.96025574
65PRKG20.95585736
66PIM20.95571417
67MARK30.94442925
68DMPK0.93890456
69EPHA20.93681735
70PIM10.92792968
71JAK20.92687959
72LATS20.90793524
73CDK120.85316955
74TTN0.83647889
75FGR0.81057892
76EEF2K0.77185803
77LYN0.72782369
78HIPK20.72500483
79RPS6KL10.72325767
80RPS6KC10.72325767
81ICK0.71553437
82CDK60.70543948
83PKN20.69884406
84MAP2K20.69694245
85TAOK10.68838316
86PAK20.68483534
87MAPKAPK20.68251739
88BRAF0.64512510
89CDK90.63451054
90STK110.59444863
91ALK0.58032413
92PDGFRB0.57388971
93PDPK10.56675296
94KSR20.56619203
95MTOR0.55942000
96PDK20.55904994
97CDK40.55835168
98IRAK10.55696322
99BMX0.55164493
100STK240.54913026
101ABL20.54097308
102ARAF0.51968250
103ABL10.51333495
104CAMK1D0.50723253
105MATK0.50596892
106PDGFRA0.49554064
107MAPKAPK30.49217807
108TAOK30.48981554
109BRD40.48544345
110INSR0.46039235
111RPS6KB20.45729014
112MAPK120.44959661
113MAP3K80.44206322
114TRPM70.43240590
115PTK2B0.42990271
116PRKAA20.42483888
117EGFR0.42119023
118RPS6KA10.42053953
119PRKD20.41813918
120GSK3A0.41668474
121MAPK110.41557856
122RPS6KA20.41086876
123MAP3K70.40025642
124MAP3K90.39878415
125PRKCQ0.38965106
126PKN10.38600749
127PRKD10.38492689
128MAPK40.37674194
129MAPK70.37094125
130MAP3K10.36383764
131MELK0.35579353
132CAMK1G0.35205796
133PDK10.32529399
134DYRK1B0.32205240
135RPS6KA60.31885825

Predicted pathways (KEGG)

RankGene SetZ-score
1Osteoclast differentiation_Homo sapiens_hsa043802.65755646
2Leishmaniasis_Homo sapiens_hsa051402.57446762
3B cell receptor signaling pathway_Homo sapiens_hsa046622.27426716
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.22311379
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.93286010
6Antigen processing and presentation_Homo sapiens_hsa046121.89648461
7Toll-like receptor signaling pathway_Homo sapiens_hsa046201.81282854
8Toxoplasmosis_Homo sapiens_hsa051451.78262399
9TNF signaling pathway_Homo sapiens_hsa046681.76368205
10Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.76328835
11Measles_Homo sapiens_hsa051621.74203752
12Graft-versus-host disease_Homo sapiens_hsa053321.73654600
13T cell receptor signaling pathway_Homo sapiens_hsa046601.69625856
14Pertussis_Homo sapiens_hsa051331.68302414
15Primary immunodeficiency_Homo sapiens_hsa053401.67723307
16Staphylococcus aureus infection_Homo sapiens_hsa051501.63871436
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.60549130
18AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.60381434
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.58824015
20Tuberculosis_Homo sapiens_hsa051521.55283830
21Malaria_Homo sapiens_hsa051441.53214836
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.52081302
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.52003700
24Hematopoietic cell lineage_Homo sapiens_hsa046401.47427171
25Chemokine signaling pathway_Homo sapiens_hsa040621.43849595
26Bladder cancer_Homo sapiens_hsa052191.38759969
27Legionellosis_Homo sapiens_hsa051341.38138501
28Leukocyte transendothelial migration_Homo sapiens_hsa046701.37637287
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.36710948
30Allograft rejection_Homo sapiens_hsa053301.31965060
31Chronic myeloid leukemia_Homo sapiens_hsa052201.31507009
32Apoptosis_Homo sapiens_hsa042101.31463263
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.29429746
34Influenza A_Homo sapiens_hsa051641.27896609
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.24075535
36Salmonella infection_Homo sapiens_hsa051321.21766122
37Shigellosis_Homo sapiens_hsa051311.21598172
38Hepatitis B_Homo sapiens_hsa051611.20835879
39African trypanosomiasis_Homo sapiens_hsa051431.20438586
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.17920503
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.17689141
42Acute myeloid leukemia_Homo sapiens_hsa052211.17552345
43Other glycan degradation_Homo sapiens_hsa005111.17072781
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.16698605
45Platelet activation_Homo sapiens_hsa046111.11834240
46Herpes simplex infection_Homo sapiens_hsa051681.11680763
47Rheumatoid arthritis_Homo sapiens_hsa053231.08742928
48Pancreatic cancer_Homo sapiens_hsa052121.07497180
49Systemic lupus erythematosus_Homo sapiens_hsa053221.04216880
50Viral myocarditis_Homo sapiens_hsa054161.01195346
51Neurotrophin signaling pathway_Homo sapiens_hsa047221.00700142
52Small cell lung cancer_Homo sapiens_hsa052220.94058122
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.93377213
54Amoebiasis_Homo sapiens_hsa051460.92875106
55VEGF signaling pathway_Homo sapiens_hsa043700.92765185
56Lysosome_Homo sapiens_hsa041420.90470753
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.89827106
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.89076080
59Prolactin signaling pathway_Homo sapiens_hsa049170.89019955
60Asthma_Homo sapiens_hsa053100.88001838
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.87349617
62Hepatitis C_Homo sapiens_hsa051600.83598519
63MAPK signaling pathway_Homo sapiens_hsa040100.81414761
64HTLV-I infection_Homo sapiens_hsa051660.78509400
65Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.78370643
66Proteoglycans in cancer_Homo sapiens_hsa052050.77028029
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76000187
68Colorectal cancer_Homo sapiens_hsa052100.75834323
69Focal adhesion_Homo sapiens_hsa045100.75676292
70p53 signaling pathway_Homo sapiens_hsa041150.74593430
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.74378929
72Renal cell carcinoma_Homo sapiens_hsa052110.74325324
73Estrogen signaling pathway_Homo sapiens_hsa049150.72018064
74Adherens junction_Homo sapiens_hsa045200.71631370
75Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70968847
76Endocytosis_Homo sapiens_hsa041440.70653741
77Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69162530
78MicroRNAs in cancer_Homo sapiens_hsa052060.68978400
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68755414
80Epstein-Barr virus infection_Homo sapiens_hsa051690.68331337
81Prion diseases_Homo sapiens_hsa050200.66997886
82Dorso-ventral axis formation_Homo sapiens_hsa043200.65171876
83FoxO signaling pathway_Homo sapiens_hsa040680.64675956
84Viral carcinogenesis_Homo sapiens_hsa052030.63989661
85Endometrial cancer_Homo sapiens_hsa052130.62069476
86Rap1 signaling pathway_Homo sapiens_hsa040150.61383852
87Autoimmune thyroid disease_Homo sapiens_hsa053200.60890642
88mTOR signaling pathway_Homo sapiens_hsa041500.59903092
89Phagosome_Homo sapiens_hsa041450.58845189
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58652311
91GnRH signaling pathway_Homo sapiens_hsa049120.56286396
92HIF-1 signaling pathway_Homo sapiens_hsa040660.55980962
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55819036
94Non-small cell lung cancer_Homo sapiens_hsa052230.55756495
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.55513891
96Glioma_Homo sapiens_hsa052140.55300515
97Renin secretion_Homo sapiens_hsa049240.54941953
98Notch signaling pathway_Homo sapiens_hsa043300.54690379
99Type I diabetes mellitus_Homo sapiens_hsa049400.54672387
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.53233992
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52680958
102Insulin resistance_Homo sapiens_hsa049310.51198823
103Prostate cancer_Homo sapiens_hsa052150.50729495
104Pathways in cancer_Homo sapiens_hsa052000.49691605
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49147281
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48209105
107ECM-receptor interaction_Homo sapiens_hsa045120.46781840
108Type II diabetes mellitus_Homo sapiens_hsa049300.46565382
109ErbB signaling pathway_Homo sapiens_hsa040120.46085619
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.43287342
111Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39958620

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