IFI16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.62207796
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.59916857
3antigen processing and presentation of endogenous antigen (GO:0019883)5.51918176
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.37657053
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.33558050
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.01216796
7negative regulation of cell killing (GO:0031342)5.01216796
8regulation of B cell receptor signaling pathway (GO:0050855)4.85550771
9type I interferon signaling pathway (GO:0060337)4.67760092
10cellular response to type I interferon (GO:0071357)4.67760092
11response to type I interferon (GO:0034340)4.64934248
12positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.37731771
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.34848377
14positive regulation by organism of defense response of other organism involved in symbiotic interact4.34848377
15modulation by symbiont of host immune response (GO:0052553)4.34848377
16positive regulation by symbiont of host defense response (GO:0052509)4.34848377
17modulation by symbiont of host defense response (GO:0052031)4.34848377
18modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.34848377
19immunoglobulin mediated immune response (GO:0016064)4.30156260
20negative thymic T cell selection (GO:0045060)4.12663676
21negative T cell selection (GO:0043383)4.12314018
22regulation of gamma-delta T cell activation (GO:0046643)4.08869368
23detection of other organism (GO:0098543)4.05596470
24positive thymic T cell selection (GO:0045059)4.00022563
25interferon-gamma-mediated signaling pathway (GO:0060333)3.96564876
26detection of bacterium (GO:0016045)3.92039153
27response to interleukin-15 (GO:0070672)3.89876031
28macrophage activation involved in immune response (GO:0002281)3.86189645
29B cell receptor signaling pathway (GO:0050853)3.84187530
30regulation of gamma-delta T cell differentiation (GO:0045586)3.83230220
31cellular response to interleukin-15 (GO:0071350)3.71939793
32regulation of interferon-beta biosynthetic process (GO:0045357)3.67544220
33positive regulation of B cell differentiation (GO:0045579)3.66856315
34T cell migration (GO:0072678)3.65741895
35negative regulation of interleukin-12 production (GO:0032695)3.65477674
36leukocyte aggregation (GO:0070486)3.65310333
37response to interferon-alpha (GO:0035455)3.60452049
38antigen processing and presentation via MHC class Ib (GO:0002475)3.59328960
39detection of external biotic stimulus (GO:0098581)3.59069601
40neutrophil activation involved in immune response (GO:0002283)3.57784825
41B cell mediated immunity (GO:0019724)3.54685888
42positive T cell selection (GO:0043368)3.52216547
43detection of molecule of bacterial origin (GO:0032490)3.48573179
44regulation of B cell differentiation (GO:0045577)3.43321554
45positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.41530031
46regulation of T cell tolerance induction (GO:0002664)3.41296675
47response to peptidoglycan (GO:0032494)3.40157744
48thymic T cell selection (GO:0045061)3.40133421
49response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.39121276
50response to host immune response (GO:0052572)3.39121276
51negative regulation of T cell mediated immunity (GO:0002710)3.38780151
52regulation of alpha-beta T cell proliferation (GO:0046640)3.33828303
53positive regulation of interferon-alpha production (GO:0032727)3.33798543
54regulation of dendritic cell antigen processing and presentation (GO:0002604)3.33514290
55positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.33025602
56T cell selection (GO:0045058)3.31160128
57negative regulation of lymphocyte mediated immunity (GO:0002707)3.28443499
58response to interferon-beta (GO:0035456)3.27709750
59regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.22819332
60response to host defenses (GO:0052200)3.22794996
61response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.22794996
62response to host (GO:0075136)3.22794996
63regulation of antigen processing and presentation (GO:0002577)3.22482330
64regulation of tolerance induction (GO:0002643)3.20532260
65regulation of interferon-alpha production (GO:0032647)3.16418863
66* negative regulation of viral genome replication (GO:0045071)3.13231158
67detection of biotic stimulus (GO:0009595)3.10695398
68myeloid cell activation involved in immune response (GO:0002275)3.10666847
69germinal center formation (GO:0002467)3.08308208
70negative regulation of leukocyte mediated immunity (GO:0002704)3.07874061
71cellular extravasation (GO:0045123)3.06199751
72cellular response to interferon-gamma (GO:0071346)3.05852377
73defense response to protozoan (GO:0042832)3.05088580
74positive regulation of granulocyte differentiation (GO:0030854)3.03324100
75NIK/NF-kappaB signaling (GO:0038061)3.02957893
76positive regulation of antigen processing and presentation (GO:0002579)3.02336507
77positive regulation of tolerance induction (GO:0002645)3.00955061
78regulation of regulatory T cell differentiation (GO:0045589)3.00455929
79positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.96698027
80regulation of T cell mediated cytotoxicity (GO:0001914)2.93486967
81response to muramyl dipeptide (GO:0032495)2.91053781
82tolerance induction (GO:0002507)2.90761639
83antigen receptor-mediated signaling pathway (GO:0050851)2.89343931
84lipopolysaccharide-mediated signaling pathway (GO:0031663)2.89173103
85positive regulation of alpha-beta T cell proliferation (GO:0046641)2.88403844
86negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.87194131
87positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.87105041
88regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.86830140
89positive regulation of T cell mediated cytotoxicity (GO:0001916)2.86687867
90regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.86374126
91microglial cell activation (GO:0001774)2.86105353
92regulation of type I interferon-mediated signaling pathway (GO:0060338)2.84365393
93regulation of natural killer cell mediated immunity (GO:0002715)2.83101879
94regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.83101879
95negative regulation of T-helper cell differentiation (GO:0045623)2.82267760
96negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.82267760
97T cell costimulation (GO:0031295)2.81378921
98response to interferon-gamma (GO:0034341)2.78316042
99response to protozoan (GO:0001562)2.77547964
100lymphocyte costimulation (GO:0031294)2.77059448

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.23498717
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.52238757
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.74544988
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.55451749
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.48783383
6IRF8_21731497_ChIP-ChIP_J774_Mouse4.11889307
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.57449667
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.24410039
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.15306323
10IRF8_27001747_Chip-Seq_BMDM_Mouse3.03358917
11RUNX_20019798_ChIP-Seq_JUKART_Human3.00697200
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.00500774
13* MYB_26560356_Chip-Seq_TH2_Human2.82731840
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.76483412
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.71404075
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.68342235
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.68025454
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.55006920
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.52785081
20SPI1_23547873_ChIP-Seq_NB4_Human2.43612441
21FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.31114379
22* MYB_26560356_Chip-Seq_TH1_Human2.26005443
23* MAF_26560356_Chip-Seq_TH1_Human2.24754293
24RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.23640927
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.23155848
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.20581893
27MYC_22102868_ChIP-Seq_BL_Human2.11170156
28VDR_24763502_ChIP-Seq_THP-1_Human2.09178806
29SCL_19346495_ChIP-Seq_HPC-7_Human2.06233297
30RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.05825802
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.03148035
32ELF1_17652178_ChIP-ChIP_JURKAT_Human1.97236495
33SPI1_23127762_ChIP-Seq_K562_Human1.95215779
34BRD4_27068464_Chip-Seq_AML-cells_Mouse1.92343741
35VDR_21846776_ChIP-Seq_THP-1_Human1.89457576
36Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.87134982
37* UTX_26944678_Chip-Seq_JUKART_Human1.86455111
38RUNX1_22412390_ChIP-Seq_EML_Mouse1.84311535
39E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.83200110
40* GATA3_27048872_Chip-Seq_THYMUS_Human1.79971236
41GATA1_22025678_ChIP-Seq_K562_Human1.71867687
42GATA2_21666600_ChIP-Seq_HMVEC_Human1.71517041
43VDR_24787735_ChIP-Seq_THP-1_Human1.65963189
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.60519423
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.59296706
46TP63_17297297_ChIP-ChIP_HaCaT_Human1.56813095
47* MAF_26560356_Chip-Seq_TH2_Human1.53260378
48GATA3_26560356_Chip-Seq_TH2_Human1.51899825
49MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.47361911
50ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.43127421
51TCF7_22412390_ChIP-Seq_EML_Mouse1.34625945
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.33674488
53GATA2_22383799_ChIP-Seq_G1ME_Mouse1.33618907
54PU_27001747_Chip-Seq_BMDM_Mouse1.30935258
55LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.30399297
56NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.27219009
57RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.22392199
58CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21257156
59LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.21205245
60SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.20413160
61KDM2B_26808549_Chip-Seq_SUP-B15_Human1.20088883
62ELK3_25401928_ChIP-Seq_HUVEC_Human1.17323926
63STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.17171014
64TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.15333745
65PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14209484
66PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12314957
67KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.08428199
68GATA1_19941827_ChIP-Seq_MEL_Mouse1.07488871
69KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.06773011
70GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06174994
71PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05062522
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03944988
73KDM2B_26808549_Chip-Seq_DND41_Human1.01662995
74TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99228822
75PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98410629
76CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.95777966
77CIITA_25753668_ChIP-Seq_RAJI_Human0.95121782
78GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94876677
79CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94613274
80CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92795989
81CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92357815
82VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.88335506
83SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87245438
84STAT6_21828071_ChIP-Seq_BEAS2B_Human0.85986226
85TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.85224177
86GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83584372
87SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79180411
88GATA1_19941826_ChIP-Seq_K562_Human0.78826633
89PU.1_20513432_ChIP-Seq_Bcells_Mouse0.75549062
90BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.75309942
91TFEB_21752829_ChIP-Seq_HELA_Human0.72947999
92JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71679205
93SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.70652659
94SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.70652659
95SMRT_27268052_Chip-Seq_Bcells_Human0.67321779
96GATA2_19941826_ChIP-Seq_K562_Human0.66966168
97GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.65218869
98NCOR1_26117541_ChIP-Seq_K562_Human0.65171965
99JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.64277867
100* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.63320967

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.34211934
2MP0003724_increased_susceptibility_to4.01965708
3MP0005671_abnormal_response_to3.48199780
4MP0003436_decreased_susceptibility_to3.29822280
5MP0000685_abnormal_immune_system3.18156669
6MP0001800_abnormal_humoral_immune3.02121697
7MP0005387_immune_system_phenotype3.02108814
8MP0001790_abnormal_immune_system3.02108814
9MP0009785_altered_susceptibility_to2.99126122
10MP0003763_abnormal_thymus_physiology2.97964179
11MP0005000_abnormal_immune_tolerance2.96430293
12MP0003303_peritoneal_inflammation2.77928762
13MP0005025_abnormal_response_to2.63432880
14MP0002723_abnormal_immune_serum2.58516487
15MP0002419_abnormal_innate_immunity2.55706066
16MP0002452_abnormal_antigen_presenting2.55308114
17MP0002148_abnormal_hypersensitivity_rea2.51274098
18MP0003300_gastrointestinal_ulcer2.44625611
19MP0002420_abnormal_adaptive_immunity2.43862118
20MP0002166_altered_tumor_susceptibility2.42381026
21MP0001819_abnormal_immune_cell2.41309452
22MP0006082_CNS_inflammation2.27957563
23MP0002398_abnormal_bone_marrow2.00714699
24MP0002405_respiratory_system_inflammati1.99306925
25MP0010155_abnormal_intestine_physiology1.98914265
26MP0000716_abnormal_immune_system1.91260671
27MP0004947_skin_inflammation1.89253092
28MP0009333_abnormal_splenocyte_physiolog1.89033226
29MP0001533_abnormal_skeleton_physiology1.83521427
30MP0002006_tumorigenesis1.78725652
31MP0005464_abnormal_platelet_physiology1.74378789
32MP0002396_abnormal_hematopoietic_system1.72874340
33MP0001845_abnormal_inflammatory_respons1.71408948
34MP0000465_gastrointestinal_hemorrhage1.68689261
35MP0004381_abnormal_hair_follicle1.63177916
36MP0000689_abnormal_spleen_morphology1.60212916
37MP0002722_abnormal_immune_system1.59130828
38MP0003191_abnormal_cellular_cholesterol1.56571208
39MP0002429_abnormal_blood_cell1.54500946
40MP0008260_abnormal_autophagy1.54256595
41MP0000703_abnormal_thymus_morphology1.50918126
42MP0003828_pulmonary_edema1.50225264
43MP0006054_spinal_hemorrhage1.49270758
44MP0000858_altered_metastatic_potential1.43577593
45MP0001853_heart_inflammation1.40434297
46MP0003866_abnormal_defecation1.34736073
47MP0003448_altered_tumor_morphology1.33295054
48MP0002877_abnormal_melanocyte_morpholog1.32888009
49MP0008469_abnormal_protein_level1.32773525
50MP0002998_abnormal_bone_remodeling1.28181447
51MP0009764_decreased_sensitivity_to1.27864208
52MP0001873_stomach_inflammation1.27189769
53MP0002933_joint_inflammation1.25704764
54MP0003045_fibrosis1.25494422
55MP0001851_eye_inflammation1.24389408
56MP0005075_abnormal_melanosome_morpholog1.23950856
57MP0005310_abnormal_salivary_gland1.23064516
58MP0003172_abnormal_lysosome_physiology1.18900834
59MP0009278_abnormal_bone_marrow1.17634630
60MP0002138_abnormal_hepatobiliary_system1.12932044
61MP0004808_abnormal_hematopoietic_stem1.11549169
62MP0001545_abnormal_hematopoietic_system1.05256632
63MP0005397_hematopoietic_system_phenotyp1.05256632
64MP0005451_abnormal_body_composition1.04151237
65MP0008438_abnormal_cutaneous_collagen1.04125334
66MP0004883_abnormal_blood_vessel1.01765843
67MP0005164_abnormal_response_to1.01520616
68MP0003075_altered_response_to1.01182227
69MP0001958_emphysema0.99824569
70MP0005166_decreased_susceptibility_to0.99435523
71MP0003091_abnormal_cell_migration0.99093314
72MP0002132_abnormal_respiratory_system0.97973260
73MP0003183_abnormal_peptide_metabolism0.97606245
74MP0000343_altered_response_to0.93922898
75MP0009763_increased_sensitivity_to0.93677659
76MP0005390_skeleton_phenotype0.92353260
77MP0000015_abnormal_ear_pigmentation0.92177446
78MP0000569_abnormal_digit_pigmentation0.90099085
79MP0003279_aneurysm0.87834831
80MP0005275_abnormal_skin_tensile0.83280955
81MP0000249_abnormal_blood_vessel0.78691613
82MP0005023_abnormal_wound_healing0.78479016
83MP0005058_abnormal_lysosome_morphology0.77882911
84MP0004510_myositis0.74564379
85MP0003795_abnormal_bone_structure0.72266669
86MP0002019_abnormal_tumor_incidence0.72204682
87MP0003806_abnormal_nucleotide_metabolis0.71630267
88MP0002009_preneoplasia0.71255131
89MP0005165_increased_susceptibility_to0.67619308
90MP0001663_abnormal_digestive_system0.66369603
91MP0008004_abnormal_stomach_pH0.66066060
92MP0000604_amyloidosis0.63018755
93MP0003453_abnormal_keratinocyte_physiol0.60533044
94MP0009765_abnormal_xenobiotic_induced0.55214440
95MP0003566_abnormal_cell_adhesion0.55194634
96MP0000371_diluted_coat_color0.54938941
97MP0000490_abnormal_crypts_of0.54378527
98MP0002060_abnormal_skin_morphology0.54100980
99MP0001542_abnormal_bone_strength0.53756169
100MP0003656_abnormal_erythrocyte_physiolo0.53000355

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.83943926
2Myositis (HP:0100614)4.50121828
3Elevated erythrocyte sedimentation rate (HP:0003565)4.46123386
4Recurrent bacterial skin infections (HP:0005406)4.45685355
5T lymphocytopenia (HP:0005403)4.40395903
6Recurrent abscess formation (HP:0002722)4.35697209
7Abnormality of T cell number (HP:0011839)4.31098855
8Abnormal delayed hypersensitivity skin test (HP:0002963)4.26070397
9Orchitis (HP:0100796)4.17307256
10Recurrent fungal infections (HP:0002841)4.15438851
11Meningitis (HP:0001287)4.03020661
12Retrobulbar optic neuritis (HP:0100654)3.97171692
13Optic neuritis (HP:0100653)3.97171692
14Recurrent viral infections (HP:0004429)3.93464299
15Chronic mucocutaneous candidiasis (HP:0002728)3.89748526
16Recurrent cutaneous fungal infections (HP:0011370)3.89748526
17Abnormality of macrophages (HP:0004311)3.77907539
18Panhypogammaglobulinemia (HP:0003139)3.70560264
19Mediastinal lymphadenopathy (HP:0100721)3.65990915
20Vasculitis (HP:0002633)3.64485539
21Agammaglobulinemia (HP:0004432)3.54361338
22Recurrent skin infections (HP:0001581)3.51637766
23Spontaneous hematomas (HP:0007420)3.50284296
24Abnormality of T cells (HP:0002843)3.45837555
25Stomatitis (HP:0010280)3.45730783
26Gastrointestinal infarctions (HP:0005244)3.43252512
27Recurrent bronchitis (HP:0002837)3.42361647
28Pulmonary infiltrates (HP:0002113)3.40976239
29Increased IgE level (HP:0003212)3.32042622
30Autoimmune hemolytic anemia (HP:0001890)3.31350785
31Encephalitis (HP:0002383)3.26808922
32Cellulitis (HP:0100658)3.14453589
33Recurrent gram-negative bacterial infections (HP:0005420)3.13734804
34Increased IgM level (HP:0003496)3.13349075
35Keratoconjunctivitis sicca (HP:0001097)3.10260962
36Granulocytopenia (HP:0001913)3.02693954
37Hemoptysis (HP:0002105)3.02224477
38Eosinophilia (HP:0001880)3.01549257
39Chronic obstructive pulmonary disease (HP:0006510)2.99334401
40Obstructive lung disease (HP:0006536)2.99334401
41Chest pain (HP:0100749)2.98182751
42Abnormality of B cell number (HP:0010975)2.97234565
43Urticaria (HP:0001025)2.93566702
44Gingivitis (HP:0000230)2.89559141
45Abnormality of T cell physiology (HP:0011840)2.85964843
46Pustule (HP:0200039)2.85762817
47Leukocytosis (HP:0001974)2.85696550
48Keratoconjunctivitis (HP:0001096)2.84508004
49IgG deficiency (HP:0004315)2.83711844
50B lymphocytopenia (HP:0010976)2.79525123
51Hypergammaglobulinemia (HP:0010702)2.74614179
52Gastrointestinal stroma tumor (HP:0100723)2.71380881
53Osteomyelitis (HP:0002754)2.63368951
54Arterial thrombosis (HP:0004420)2.60818107
55Inflammation of the large intestine (HP:0002037)2.58913474
56Abnormality of cells of the lymphoid lineage (HP:0012140)2.57262831
57Lymphopenia (HP:0001888)2.56296148
58Abnormality of eosinophils (HP:0001879)2.53145985
59IgM deficiency (HP:0002850)2.51673577
60Severe combined immunodeficiency (HP:0004430)2.50580367
61Gastrointestinal inflammation (HP:0004386)2.47930631
62Colitis (HP:0002583)2.47780120
63Autoimmune thrombocytopenia (HP:0001973)2.46882184
64Peritonitis (HP:0002586)2.45928061
65Chronic diarrhea (HP:0002028)2.43044195
66Papilloma (HP:0012740)2.42707845
67Verrucae (HP:0200043)2.42707845
68Gingival bleeding (HP:0000225)2.38670072
69Epistaxis (HP:0000421)2.36896886
70Pulmonary embolism (HP:0002204)2.34654571
71Abnormality of the prostate (HP:0008775)2.34282115
72Gangrene (HP:0100758)2.29537143
73Skin ulcer (HP:0200042)2.28575271
74Abnormality of the pleura (HP:0002103)2.27425874
75Abnormality of the peritoneum (HP:0002585)2.24999205
76Sepsis (HP:0100806)2.24359519
77Chronic otitis media (HP:0000389)2.18282340
78Spondylolisthesis (HP:0003302)2.16055429
79Skin rash (HP:0000988)2.14840449
80Prolonged bleeding time (HP:0003010)2.14452367
81Viral hepatitis (HP:0006562)2.11764277
82Emphysema (HP:0002097)2.11716181
83Combined immunodeficiency (HP:0005387)2.08148748
84Glomerulopathy (HP:0100820)2.06959677
85Thyroiditis (HP:0100646)2.06761303
86Lymphoma (HP:0002665)2.04428200
87IgA deficiency (HP:0002720)2.04209560
88Recurrent lower respiratory tract infections (HP:0002783)2.02957413
89Fatigue (HP:0012378)2.02367983
90Restrictive lung disease (HP:0002091)2.01711205
91Recurrent pneumonia (HP:0006532)1.99841498
92Abnormality of glycolipid metabolism (HP:0010969)1.98561675
93Abnormality of liposaccharide metabolism (HP:0010968)1.98561675
94Abnormality of glycosphingolipid metabolism (HP:0004343)1.98561675
95Premature loss of primary teeth (HP:0006323)1.96811233
96Hypoplasia of the thymus (HP:0000778)1.91852113
97Hypoproteinemia (HP:0003075)1.91817988
98Prostate neoplasm (HP:0100787)1.88801884
99Recurrent sinusitis (HP:0011108)1.88599584
100Abnormality of the pericardium (HP:0001697)1.88543928

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.07356120
2RIPK43.67563006
3TYK23.25818781
4TXK2.76718642
5MAP3K142.74299491
6BLK2.64812407
7ERN12.62662724
8JAK32.58218549
9JAK12.48752144
10KIT2.40353236
11FES2.34308952
12IKBKE2.31848409
13CSK2.30437037
14PRPF4B2.26015251
15ZAP702.11945185
16IRAK42.02619396
17MAP3K131.98599229
18SYK1.98007110
19BTK1.96085990
20TBK11.89422347
21SIK31.88970274
22TAOK31.78543610
23FGFR41.71260419
24MAP2K31.67908490
25MAP3K31.60427989
26ITK1.59972977
27HCK1.58680129
28FGFR31.51392438
29CSF1R1.50912796
30TEC1.50165202
31GRK61.46662953
32NLK1.40728290
33EPHB11.40607217
34LYN1.37809516
35BMPR21.37764032
36LCK1.36301344
37TGFBR21.35999287
38IKBKB1.31036744
39TNK21.20563183
40JAK21.19809713
41KDR1.16917547
42STK101.09962442
43PIK3CG1.01785632
44FGR0.96726786
45MAPK70.94443927
46MARK30.94324572
47NEK90.92944772
48EIF2AK30.87459405
49MATK0.87109606
50SMG10.81943783
51TRPM70.81082037
52MAPK110.79555716
53IRAK10.76858045
54PRKCQ0.73899041
55TESK20.73721847
56CDC42BPA0.73240754
57MAP3K10.71828219
58LRRK20.67655134
59CDK40.65028545
60HIPK20.64921766
61GRK70.61062447
62EPHA30.59366751
63MAP3K60.57608114
64MAPKAPK20.56682772
65MAP3K100.56351070
66MAPK120.53770700
67PTK2B0.53301385
68PDK10.52807684
69CLK10.52299427
70MAP3K110.51624918
71CDK60.51102626
72YES10.50816954
73PIM10.47100436
74PRKD20.45656364
75FYN0.45598781
76TAOK20.43611342
77ABL10.42532371
78TIE10.41969720
79SCYL20.41532602
80MELK0.41512095
81DDR20.40998909
82CAMKK20.40633684
83IRAK30.40563849
84MAPKAPK30.40115769
85CHUK0.38873791
86PDGFRB0.37996670
87RIPK10.36956502
88MAP3K20.36647522
89MAP3K70.32379806
90MAPK40.30181858
91MOS0.28524626
92PDPK10.28257733
93MARK20.27913563
94PRKCD0.27537673
95MAP3K50.26696546
96KSR20.26674028
97TGFBR10.26432515
98EGFR0.26425503
99IGF1R0.26225660
100CDK120.25533934

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.42441829
2Graft-versus-host disease_Homo sapiens_hsa053323.30373754
3Autoimmune thyroid disease_Homo sapiens_hsa053203.24319210
4Primary immunodeficiency_Homo sapiens_hsa053403.09536111
5Leishmaniasis_Homo sapiens_hsa051402.81164861
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.65811702
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.55768533
8Asthma_Homo sapiens_hsa053102.55514579
9Staphylococcus aureus infection_Homo sapiens_hsa051502.53717532
10Type I diabetes mellitus_Homo sapiens_hsa049402.40672471
11Antigen processing and presentation_Homo sapiens_hsa046122.39621694
12Osteoclast differentiation_Homo sapiens_hsa043802.24783726
13Measles_Homo sapiens_hsa051622.22030740
14B cell receptor signaling pathway_Homo sapiens_hsa046622.14963699
15NF-kappa B signaling pathway_Homo sapiens_hsa040642.06502073
16Viral myocarditis_Homo sapiens_hsa054162.05220638
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.03945689
18Hematopoietic cell lineage_Homo sapiens_hsa046401.95367034
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.89835530
20Influenza A_Homo sapiens_hsa051641.86396378
21Herpes simplex infection_Homo sapiens_hsa051681.79076045
22Tuberculosis_Homo sapiens_hsa051521.76940641
23Toxoplasmosis_Homo sapiens_hsa051451.73761136
24T cell receptor signaling pathway_Homo sapiens_hsa046601.69714238
25RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.67729060
26Malaria_Homo sapiens_hsa051441.66549232
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.54505925
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.48852198
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.45441009
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.42906546
31Rheumatoid arthritis_Homo sapiens_hsa053231.41895601
32TNF signaling pathway_Homo sapiens_hsa046681.31145460
33Hepatitis B_Homo sapiens_hsa051611.26924925
34Acute myeloid leukemia_Homo sapiens_hsa052211.24855942
35Chemokine signaling pathway_Homo sapiens_hsa040621.24661597
36Legionellosis_Homo sapiens_hsa051341.16036556
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.15152082
38Hepatitis C_Homo sapiens_hsa051601.14491252
39African trypanosomiasis_Homo sapiens_hsa051431.13651748
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.10077043
41Phagosome_Homo sapiens_hsa041451.09359747
42Shigellosis_Homo sapiens_hsa051311.08467483
43Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.07768048
44Pertussis_Homo sapiens_hsa051331.04990944
45Pancreatic cancer_Homo sapiens_hsa052121.03733876
46Apoptosis_Homo sapiens_hsa042101.01440313
47Platelet activation_Homo sapiens_hsa046110.98969748
48Other glycan degradation_Homo sapiens_hsa005110.95699211
49Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.95633146
50Leukocyte transendothelial migration_Homo sapiens_hsa046700.95318501
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.93214515
52Non-small cell lung cancer_Homo sapiens_hsa052230.91675513
53Epstein-Barr virus infection_Homo sapiens_hsa051690.88557784
54Chronic myeloid leukemia_Homo sapiens_hsa052200.85315750
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83488137
56Salmonella infection_Homo sapiens_hsa051320.81665148
57HTLV-I infection_Homo sapiens_hsa051660.79408374
58Viral carcinogenesis_Homo sapiens_hsa052030.75325360
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72923493
60VEGF signaling pathway_Homo sapiens_hsa043700.66121225
61Prolactin signaling pathway_Homo sapiens_hsa049170.65988019
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60772972
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57783144
64Lysosome_Homo sapiens_hsa041420.56620082
65Systemic lupus erythematosus_Homo sapiens_hsa053220.56480334
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.55706894
67Endocytosis_Homo sapiens_hsa041440.53572191
68Amoebiasis_Homo sapiens_hsa051460.53009920
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52920521
70Small cell lung cancer_Homo sapiens_hsa052220.52595808
71Dorso-ventral axis formation_Homo sapiens_hsa043200.52344523
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.50885548
73Renal cell carcinoma_Homo sapiens_hsa052110.50803887
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.46340840
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42041857
76HIF-1 signaling pathway_Homo sapiens_hsa040660.40947684
77Prostate cancer_Homo sapiens_hsa052150.39673837
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38541096
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.37745641
80FoxO signaling pathway_Homo sapiens_hsa040680.36153230
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35436323
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.31585110
83Focal adhesion_Homo sapiens_hsa045100.31312362
84Proteoglycans in cancer_Homo sapiens_hsa052050.30494366
85Notch signaling pathway_Homo sapiens_hsa043300.30454431
86Bladder cancer_Homo sapiens_hsa052190.29676338
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.29268277
88Insulin resistance_Homo sapiens_hsa049310.28991243
89Glioma_Homo sapiens_hsa052140.28758111
90MAPK signaling pathway_Homo sapiens_hsa040100.27831302
91mTOR signaling pathway_Homo sapiens_hsa041500.26623620
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.26604978
93Colorectal cancer_Homo sapiens_hsa052100.26245559
94Choline metabolism in cancer_Homo sapiens_hsa052310.22423587
95GnRH signaling pathway_Homo sapiens_hsa049120.22193551
96Endometrial cancer_Homo sapiens_hsa052130.21010100
97p53 signaling pathway_Homo sapiens_hsa041150.20736061
98Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.19489767
99Complement and coagulation cascades_Homo sapiens_hsa046100.19453547
100Inositol phosphate metabolism_Homo sapiens_hsa005620.19031433

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