IFI27L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.80691737
2ATP synthesis coupled proton transport (GO:0015986)6.03422310
3energy coupled proton transport, down electrochemical gradient (GO:0015985)6.03422310
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.82317761
5respiratory electron transport chain (GO:0022904)5.43531153
6electron transport chain (GO:0022900)5.32057673
7establishment of protein localization to mitochondrial membrane (GO:0090151)4.89215517
8protein neddylation (GO:0045116)4.86769966
9protein complex biogenesis (GO:0070271)4.79523060
10chaperone-mediated protein transport (GO:0072321)4.47675970
11mitochondrial respiratory chain complex assembly (GO:0033108)4.42440931
12mitochondrial respiratory chain complex I assembly (GO:0032981)4.34257651
13NADH dehydrogenase complex assembly (GO:0010257)4.34257651
14mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.34257651
15regulation of mitochondrial translation (GO:0070129)4.01439947
16proteasome assembly (GO:0043248)4.00980131
17viral transcription (GO:0019083)3.98865845
18sequestering of actin monomers (GO:0042989)3.95689197
19translational termination (GO:0006415)3.94553777
20SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.86903723
21cotranslational protein targeting to membrane (GO:0006613)3.85632572
22ribosomal small subunit assembly (GO:0000028)3.81609637
23protein targeting to ER (GO:0045047)3.78642169
24establishment of protein localization to endoplasmic reticulum (GO:0072599)3.67114723
25respiratory chain complex IV assembly (GO:0008535)3.61171536
26protein localization to endoplasmic reticulum (GO:0070972)3.60152989
27hydrogen ion transmembrane transport (GO:1902600)3.58486993
28ATP biosynthetic process (GO:0006754)3.53107086
29inner mitochondrial membrane organization (GO:0007007)3.49627209
30chromatin remodeling at centromere (GO:0031055)3.38325652
31cullin deneddylation (GO:0010388)3.34808890
32cytochrome complex assembly (GO:0017004)3.34191386
33translational elongation (GO:0006414)3.33148370
34nonmotile primary cilium assembly (GO:0035058)3.26465448
35purine nucleoside triphosphate biosynthetic process (GO:0009145)3.25460198
36purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.24734433
37CENP-A containing nucleosome assembly (GO:0034080)3.20618688
38proton transport (GO:0015992)3.19576174
39protein-cofactor linkage (GO:0018065)3.18342987
40regulation of cilium movement (GO:0003352)3.17384553
41maturation of SSU-rRNA (GO:0030490)3.15039635
42viral life cycle (GO:0019058)3.12301133
43termination of RNA polymerase III transcription (GO:0006386)3.11733501
44transcription elongation from RNA polymerase III promoter (GO:0006385)3.11733501
45hydrogen transport (GO:0006818)3.11698648
46protein deneddylation (GO:0000338)3.11508383
47oxidative phosphorylation (GO:0006119)3.09614150
48cellular protein complex disassembly (GO:0043624)3.09418811
49ribosomal small subunit biogenesis (GO:0042274)3.08662947
50protein targeting to mitochondrion (GO:0006626)3.04911906
51negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.04192307
52nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.04081201
53establishment of protein localization to mitochondrion (GO:0072655)3.01800734
54epithelial cilium movement (GO:0003351)2.99374385
55protein localization to mitochondrion (GO:0070585)2.96815161
56translation (GO:0006412)2.95472502
57platelet dense granule organization (GO:0060155)2.91347684
58peptidyl-histidine modification (GO:0018202)2.91313992
59exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.89094276
60ribonucleoside triphosphate biosynthetic process (GO:0009201)2.89080214
61ribosomal large subunit biogenesis (GO:0042273)2.87146543
62positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.86641585
63nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.82877624
64regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.82398876
65translational initiation (GO:0006413)2.81577608
66aldehyde catabolic process (GO:0046185)2.79620249
67behavioral response to nicotine (GO:0035095)2.78168447
68intraciliary transport (GO:0042073)2.77412511
69negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.74451106
70negative regulation of ligase activity (GO:0051352)2.74451106
71nucleoside triphosphate biosynthetic process (GO:0009142)2.69380058
72anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.69203562
73kinetochore assembly (GO:0051382)2.69187285
74intracellular protein transmembrane import (GO:0044743)2.69012516
75deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.68965730
76protein complex disassembly (GO:0043241)2.68248277
77RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.66644121
78tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.66644121
79regulation of cellular amino acid metabolic process (GO:0006521)2.64996797
80DNA damage response, detection of DNA damage (GO:0042769)2.64284295
81spliceosomal snRNP assembly (GO:0000387)2.63851299
82cellular component biogenesis (GO:0044085)2.61810371
83mitochondrial transport (GO:0006839)2.61318498
84mannosylation (GO:0097502)2.61273738
85macromolecular complex disassembly (GO:0032984)2.59873409
867-methylguanosine mRNA capping (GO:0006370)2.58537927
87epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.58057896
88pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.56179421
89substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.55568507
90substrate-independent telencephalic tangential migration (GO:0021826)2.55568507
91negative regulation of appetite (GO:0032099)2.55070640
92negative regulation of response to food (GO:0032096)2.55070640
93positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.51795771
94RNA capping (GO:0036260)2.50780267
957-methylguanosine RNA capping (GO:0009452)2.50780267
96ubiquinone biosynthetic process (GO:0006744)2.49461178
97anterograde synaptic vesicle transport (GO:0048490)2.48114181
98histone exchange (GO:0043486)2.47102663
99DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.46928860
100protein targeting to membrane (GO:0006612)2.46488492

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.80594919
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.23456008
3EST1_17652178_ChIP-ChIP_JURKAT_Human4.07224213
4* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.39463234
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.38921938
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.33072334
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.18226260
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.15853541
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.11620592
10CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.83229998
11EZH2_22144423_ChIP-Seq_EOC_Human2.66154335
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.62029609
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.59814255
14PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.50585749
15ELK1_19687146_ChIP-ChIP_HELA_Human2.29976506
16THAP11_20581084_ChIP-Seq_MESCs_Mouse2.28440648
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.25171887
18VDR_23849224_ChIP-Seq_CD4+_Human2.17441306
19SRF_21415370_ChIP-Seq_HL-1_Mouse2.16133278
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.12243323
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.09120418
22E2F4_17652178_ChIP-ChIP_JURKAT_Human1.98376566
23FOXP3_21729870_ChIP-Seq_TREG_Human1.87539678
24XRN2_22483619_ChIP-Seq_HELA_Human1.86440131
25ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.86287185
26TTF2_22483619_ChIP-Seq_HELA_Human1.85911937
27GABP_19822575_ChIP-Seq_HepG2_Human1.84264891
28E2F1_18555785_ChIP-Seq_MESCs_Mouse1.80498343
29YY1_21170310_ChIP-Seq_MESCs_Mouse1.79001427
30EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.77038429
31DCP1A_22483619_ChIP-Seq_HELA_Human1.76820852
32MYC_19030024_ChIP-ChIP_MESCs_Mouse1.76358259
33MYC_18940864_ChIP-ChIP_HL60_Human1.74663238
34HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.69455410
35ZNF274_21170338_ChIP-Seq_K562_Hela1.64394164
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58226160
37DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.53322434
38FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.52414309
39E2F7_22180533_ChIP-Seq_HELA_Human1.51777249
40MYC_19079543_ChIP-ChIP_MESCs_Mouse1.48214934
41POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.46659938
42TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.46118239
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45500043
44CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.44836409
45NELFA_20434984_ChIP-Seq_ESCs_Mouse1.44122319
46RBPJ_22232070_ChIP-Seq_NCS_Mouse1.40071085
47CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.37449691
48FUS_26573619_Chip-Seq_HEK293_Human1.34890667
49EWS_26573619_Chip-Seq_HEK293_Human1.33960207
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.31390526
51SOX2_16153702_ChIP-ChIP_HESCs_Human1.29853768
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.26006369
53IRF1_19129219_ChIP-ChIP_H3396_Human1.25661848
54SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.24668547
55POU5F1_16153702_ChIP-ChIP_HESCs_Human1.23026960
56VDR_22108803_ChIP-Seq_LS180_Human1.21744809
57TP53_22573176_ChIP-Seq_HFKS_Human1.19647794
58PADI4_21655091_ChIP-ChIP_MCF-7_Human1.19508970
59YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17585419
60IGF1R_20145208_ChIP-Seq_DFB_Human1.16224091
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14698132
62CTBP2_25329375_ChIP-Seq_LNCAP_Human1.14159009
63ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.13895284
64CBX2_27304074_Chip-Seq_ESCs_Mouse1.12927660
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12617455
66ELK1_22589737_ChIP-Seq_MCF10A_Human1.11726825
67* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.11337891
68POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.10755662
69HOXB4_20404135_ChIP-ChIP_EML_Mouse1.10574777
70NANOG_16153702_ChIP-ChIP_HESCs_Human1.07431002
71SOX2_18555785_ChIP-Seq_MESCs_Mouse1.05145454
72ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04831688
73CTBP1_25329375_ChIP-Seq_LNCAP_Human1.04740753
74GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.04254524
75BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03578072
76GBX2_23144817_ChIP-Seq_PC3_Human1.02538249
77KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.95916423
78NANOG_18555785_ChIP-Seq_MESCs_Mouse0.92726911
79RNF2_27304074_Chip-Seq_NSC_Mouse0.92630423
80MYCN_18555785_ChIP-Seq_MESCs_Mouse0.92198392
81FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.91802911
82CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.90173303
83HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.90143736
84ZFP57_27257070_Chip-Seq_ESCs_Mouse0.90120995
85KDM5A_27292631_Chip-Seq_BREAST_Human0.90091733
86P300_19829295_ChIP-Seq_ESCs_Human0.89271766
87SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.89258192
88CTCF_18555785_ChIP-Seq_MESCs_Mouse0.88960022
89HTT_18923047_ChIP-ChIP_STHdh_Human0.87723945
90GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.87569514
91SRY_22984422_ChIP-ChIP_TESTIS_Rat0.87377886
92CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86135051
93REST_18959480_ChIP-ChIP_MESCs_Mouse0.83280671
94POU3F2_20337985_ChIP-ChIP_501MEL_Human0.82722699
95EZH2_27304074_Chip-Seq_ESCs_Mouse0.82266833
96EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.81756715
97BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.80017216
98CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.79906506
99ETV2_25802403_ChIP-Seq_MESCs_Mouse0.78534881
100E2F1_21310950_ChIP-Seq_MCF-7_Human0.77705180

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color3.07020749
2MP0009379_abnormal_foot_pigmentation2.60408425
3MP0006292_abnormal_olfactory_placode2.52571841
4MP0003123_paternal_imprinting2.42332175
5MP0003122_maternal_imprinting2.34451070
6MP0003880_abnormal_central_pattern2.32875062
7MP0008789_abnormal_olfactory_epithelium2.23327882
8MP0003121_genomic_imprinting2.22175479
9MP0001984_abnormal_olfaction2.19916762
10MP0001529_abnormal_vocalization2.18499019
11MP0002653_abnormal_ependyma_morphology2.07789852
12MP0005394_taste/olfaction_phenotype2.07105835
13MP0005499_abnormal_olfactory_system2.07105835
14MP0003011_delayed_dark_adaptation2.05159567
15MP0002938_white_spotting2.00891801
16MP0006072_abnormal_retinal_apoptosis1.98764485
17MP0002638_abnormal_pupillary_reflex1.97204538
18MP0008995_early_reproductive_senescence1.95240757
19MP0008877_abnormal_DNA_methylation1.95186263
20MP0003186_abnormal_redox_activity1.94306718
21MP0002822_catalepsy1.88267148
22MP0000372_irregular_coat_pigmentation1.87903261
23MP0006276_abnormal_autonomic_nervous1.85235223
24MP0002837_dystrophic_cardiac_calcinosis1.77404263
25MP0008058_abnormal_DNA_repair1.76211605
26MP0002736_abnormal_nociception_after1.71188734
27MP0004142_abnormal_muscle_tone1.71025177
28MP0009046_muscle_twitch1.70179657
29MP0010030_abnormal_orbit_morphology1.63354634
30MP0005423_abnormal_somatic_nervous1.59636205
31MP0005551_abnormal_eye_electrophysiolog1.58452865
32MP0001968_abnormal_touch/_nociception1.54416660
33MP0004133_heterotaxia1.52107097
34MP0001293_anophthalmia1.49248742
35MP0003787_abnormal_imprinting1.48420373
36MP0003786_premature_aging1.43645848
37MP0006036_abnormal_mitochondrial_physio1.39988481
38MP0000631_abnormal_neuroendocrine_gland1.38827359
39MP0002102_abnormal_ear_morphology1.37823637
40MP0005253_abnormal_eye_physiology1.36552171
41MP0002272_abnormal_nervous_system1.35781036
42MP0001905_abnormal_dopamine_level1.35738609
43MP0001188_hyperpigmentation1.31004259
44MP0002160_abnormal_reproductive_system1.30391137
45MP0008932_abnormal_embryonic_tissue1.28135611
46MP0002234_abnormal_pharynx_morphology1.26682001
47MP0006035_abnormal_mitochondrial_morpho1.26659204
48MP0005171_absent_coat_pigmentation1.26457910
49MP0002557_abnormal_social/conspecific_i1.21977605
50MP0000778_abnormal_nervous_system1.21058499
51MP0005084_abnormal_gallbladder_morpholo1.20187334
52MP0000566_synostosis1.19127951
53MP0002734_abnormal_mechanical_nocicepti1.18165306
54MP0009745_abnormal_behavioral_response1.17230436
55MP0010094_abnormal_chromosome_stability1.14351484
56MP0002735_abnormal_chemical_nociception1.13707222
57MP0005389_reproductive_system_phenotype1.13178387
58MP0003693_abnormal_embryo_hatching1.10916017
59MP0003718_maternal_effect1.09456832
60MP0002210_abnormal_sex_determination1.09068103
61MP0003890_abnormal_embryonic-extraembry1.05994220
62MP0001970_abnormal_pain_threshold1.02806079
63MP0001919_abnormal_reproductive_system0.99140594
64MP0004957_abnormal_blastocyst_morpholog0.99058586
65MP0000049_abnormal_middle_ear0.98593292
66MP0005195_abnormal_posterior_eye0.97929845
67MP0002752_abnormal_somatic_nervous0.97540600
68MP0001485_abnormal_pinna_reflex0.96614335
69MP0003315_abnormal_perineum_morphology0.96119808
70MP0002095_abnormal_skin_pigmentation0.95567715
71MP0002572_abnormal_emotion/affect_behav0.94829692
72MP0002233_abnormal_nose_morphology0.94691646
73MP0002163_abnormal_gland_morphology0.94127786
74MP0002909_abnormal_adrenal_gland0.93621099
75MP0001986_abnormal_taste_sensitivity0.92585554
76MP0002733_abnormal_thermal_nociception0.92525094
77MP0001286_abnormal_eye_development0.92193637
78MP0005391_vision/eye_phenotype0.90775704
79MP0004147_increased_porphyrin_level0.90595528
80MP0004145_abnormal_muscle_electrophysio0.90400937
81MP0009697_abnormal_copulation0.89368946
82MP0005646_abnormal_pituitary_gland0.89198307
83MP0001764_abnormal_homeostasis0.87826235
84MP0001324_abnormal_eye_pigmentation0.87411670
85MP0003698_abnormal_male_reproductive0.86402495
86MP0000653_abnormal_sex_gland0.85999978
87MP0001299_abnormal_eye_distance/0.85653559
88MP0001145_abnormal_male_reproductive0.85248268
89MP0003195_calcinosis0.84894019
90MP0001486_abnormal_startle_reflex0.84420954
91MP0001929_abnormal_gametogenesis0.83862808
92MP0000026_abnormal_inner_ear0.83532006
93MP0002090_abnormal_vision0.82047592
94MP0002067_abnormal_sensory_capabilities0.81905581
95MP0005645_abnormal_hypothalamus_physiol0.81690672
96MP0005187_abnormal_penis_morphology0.81325102
97MP0003806_abnormal_nucleotide_metabolis0.81292541
98MP0003942_abnormal_urinary_system0.81161128
99MP0002882_abnormal_neuron_morphology0.81003805
100MP0000358_abnormal_cell_content/0.79928973

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.55742411
2Abnormal mitochondria in muscle tissue (HP:0008316)5.28396266
3Mitochondrial inheritance (HP:0001427)5.02773882
4Acute encephalopathy (HP:0006846)4.99731773
5Progressive macrocephaly (HP:0004481)4.60689152
6Hepatocellular necrosis (HP:0001404)4.43252772
7Increased CSF lactate (HP:0002490)4.30189351
8Hepatic necrosis (HP:0002605)4.20064096
9Increased hepatocellular lipid droplets (HP:0006565)3.76531979
10Renal Fanconi syndrome (HP:0001994)3.55968397
11Cerebral edema (HP:0002181)3.54948512
12Decreased activity of mitochondrial respiratory chain (HP:0008972)3.50525405
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.50525405
14Abnormal number of erythroid precursors (HP:0012131)3.49818039
15Reticulocytopenia (HP:0001896)3.47426262
16Lipid accumulation in hepatocytes (HP:0006561)3.42079435
17Abnormality of cells of the erythroid lineage (HP:0012130)3.39513057
18Medial flaring of the eyebrow (HP:0010747)3.23930443
19Increased intramyocellular lipid droplets (HP:0012240)3.07741254
20Pancreatic fibrosis (HP:0100732)3.03491432
213-Methylglutaconic aciduria (HP:0003535)2.99272104
22Gait imbalance (HP:0002141)2.98078763
23Congenital primary aphakia (HP:0007707)2.92624075
24True hermaphroditism (HP:0010459)2.87330782
25Abnormality of midbrain morphology (HP:0002418)2.85721448
26Molar tooth sign on MRI (HP:0002419)2.85721448
27Lactic acidosis (HP:0003128)2.85083680
28Respiratory failure (HP:0002878)2.84657599
29Pancreatic cysts (HP:0001737)2.74742332
30Optic disc pallor (HP:0000543)2.70341226
31Nephrogenic diabetes insipidus (HP:0009806)2.66702137
32Myokymia (HP:0002411)2.63884006
33Exercise intolerance (HP:0003546)2.63846477
34Increased serum lactate (HP:0002151)2.59012695
35Increased muscle lipid content (HP:0009058)2.52481419
36Sclerocornea (HP:0000647)2.41033712
37Macrocytic anemia (HP:0001972)2.37157140
38Hyperglycinemia (HP:0002154)2.36468448
39Genital tract atresia (HP:0001827)2.34643524
40Leukodystrophy (HP:0002415)2.32990119
41Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.32956522
42Exertional dyspnea (HP:0002875)2.31257034
43Vaginal atresia (HP:0000148)2.31219143
44Abnormality of the anterior horn cell (HP:0006802)2.28990912
45Degeneration of anterior horn cells (HP:0002398)2.28990912
46Glycosuria (HP:0003076)2.26321365
47Abnormality of urine glucose concentration (HP:0011016)2.26321365
48X-linked dominant inheritance (HP:0001423)2.26024645
49Respiratory difficulties (HP:0002880)2.21777167
50Male pseudohermaphroditism (HP:0000037)2.21138873
51Nephronophthisis (HP:0000090)2.20846190
52Abnormality of the labia minora (HP:0012880)2.20596644
53Abnormal respiratory epithelium morphology (HP:0012253)2.20134029
54Abnormal respiratory motile cilium morphology (HP:0005938)2.20134029
55Generalized aminoaciduria (HP:0002909)2.19313247
56Abnormality of renal resorption (HP:0011038)2.17960022
57Septo-optic dysplasia (HP:0100842)2.10791436
58Aplasia/Hypoplasia of the sacrum (HP:0008517)2.10202977
59Lethargy (HP:0001254)2.09243202
60Polyphagia (HP:0002591)2.02662545
61CNS demyelination (HP:0007305)2.02527521
62Short tibia (HP:0005736)1.98435798
63Increased serum pyruvate (HP:0003542)1.96286172
64Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.93052875
65Supernumerary spleens (HP:0009799)1.92754789
66Emotional lability (HP:0000712)1.90661261
67Abnormal respiratory motile cilium physiology (HP:0012261)1.90426770
68Hyperphosphaturia (HP:0003109)1.88856823
69Anencephaly (HP:0002323)1.88101112
70Decreased testicular size (HP:0008734)1.86648190
71Aplasia/Hypoplasia of the tongue (HP:0010295)1.85264010
72Poor coordination (HP:0002370)1.84900914
73Aplasia/Hypoplasia of the tibia (HP:0005772)1.84756961
74Abnormal ciliary motility (HP:0012262)1.84445513
75Occipital encephalocele (HP:0002085)1.83171611
76Adrenal hypoplasia (HP:0000835)1.80560759
77Methylmalonic aciduria (HP:0012120)1.79131836
78Aganglionic megacolon (HP:0002251)1.78555309
79Retinal dysplasia (HP:0007973)1.77094780
80Anophthalmia (HP:0000528)1.75601180
81Absent septum pellucidum (HP:0001331)1.74269279
82Aplasia/Hypoplasia of the uvula (HP:0010293)1.72005643
83Abnormality of glycolysis (HP:0004366)1.71550951
84Preaxial hand polydactyly (HP:0001177)1.70296021
85Meckel diverticulum (HP:0002245)1.70111388
86Blindness (HP:0000618)1.68834468
87Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.67564284
88Colon cancer (HP:0003003)1.67299387
89Pallor (HP:0000980)1.67041235
90Type II lissencephaly (HP:0007260)1.66254857
91Aplastic anemia (HP:0001915)1.65838266
92Absent thumb (HP:0009777)1.65709965
93Rib fusion (HP:0000902)1.65697328
94Optic nerve hypoplasia (HP:0000609)1.65514428
95Hypoplastic pelvis (HP:0008839)1.65022284
96Poor suck (HP:0002033)1.64244141
97Methylmalonic acidemia (HP:0002912)1.63291699
98Congenital, generalized hypertrichosis (HP:0004540)1.61495370
99Postaxial hand polydactyly (HP:0001162)1.61334619
100Triphalangeal thumb (HP:0001199)1.61166478

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.35652004
2ZAK2.85181235
3STK162.75376129
4BCKDK2.70640757
5WNK32.40083003
6BUB12.39274935
7CASK2.35651704
8CDC72.34136645
9MAP4K22.17262275
10BMPR1B2.07571844
11DYRK22.00896704
12EPHB21.94977008
13MAP2K71.91943536
14MAP3K41.76979311
15PLK41.74191471
16VRK11.73331342
17SRPK11.57110358
18NME21.56273206
19TNIK1.53600424
20NME11.53039306
21PDK21.48972098
22CSNK1G31.47480064
23NEK11.46457069
24LIMK11.42617498
25CSNK1G21.42151714
26PLK31.41753875
27INSRR1.41162842
28NUAK11.38368796
29EIF2AK11.35637457
30PLK21.30943973
31MARK11.30391974
32EPHA41.29195598
33TESK21.26291642
34CSNK1G11.24925414
35MAPK131.23670032
36PIM21.22645127
37TRIM281.22343485
38PLK11.20994191
39GRK11.20214780
40DYRK31.19730820
41WEE11.18937184
42BCR1.18678484
43TLK11.18406623
44TESK11.16594023
45MST41.16249545
46BRSK11.15858088
47CCNB11.12966175
48PBK1.11336529
49CSNK1A1L1.10496512
50TTK1.07939047
51ADRBK21.06949639
52PRKCG1.00123508
53MUSK0.96810646
54PINK10.96378471
55AURKA0.93797353
56FRK0.91706208
57MINK10.91067914
58NTRK20.89917249
59BRSK20.88636766
60CDK190.82546298
61MAP3K120.78182707
62PHKG10.76215617
63PHKG20.76215617
64LRRK20.73977202
65CHEK20.72747364
66ABL20.72631578
67PAK30.70961812
68AURKB0.70006568
69MKNK20.69683164
70PNCK0.68064327
71ARAF0.66424090
72NTRK30.66416279
73RPS6KA50.66331602
74WNK40.65577165
75PRKCE0.64899654
76ATR0.63080374
77CDK80.62804466
78CDK140.62146440
79CSNK2A10.59210938
80PKN10.59184874
81CSNK2A20.58325713
82MKNK10.56711252
83MAP3K110.55477332
84GRK50.55321622
85BRAF0.53482266
86CDK11A0.53068376
87CDK180.51722224
88CDK150.50140928
89ERBB30.50054027
90STK38L0.49770035
91ADRBK10.49200998
92DAPK30.48757891
93CAMK2A0.47977319
94EIF2AK30.47179478
95CSNK1E0.46226461
96PRKACA0.44982493
97CSNK1A10.43423373
98FGFR20.43250312
99PAK10.43086108
100DYRK1A0.41008354

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.80047695
2Parkinsons disease_Homo sapiens_hsa050124.12402278
3Ribosome_Homo sapiens_hsa030103.55627201
4Proteasome_Homo sapiens_hsa030503.04444084
5Huntingtons disease_Homo sapiens_hsa050162.98367973
6Protein export_Homo sapiens_hsa030602.92521673
7Alzheimers disease_Homo sapiens_hsa050102.80105232
8RNA polymerase_Homo sapiens_hsa030202.48298680
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.33714105
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.19916543
11Mismatch repair_Homo sapiens_hsa034302.16961287
12Cardiac muscle contraction_Homo sapiens_hsa042602.10704454
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.01666194
14DNA replication_Homo sapiens_hsa030301.96714457
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.96428635
16Homologous recombination_Homo sapiens_hsa034401.89530264
17Fatty acid elongation_Homo sapiens_hsa000621.85200047
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.68962572
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.66953904
20Fanconi anemia pathway_Homo sapiens_hsa034601.55480198
21Folate biosynthesis_Homo sapiens_hsa007901.54450080
22Butanoate metabolism_Homo sapiens_hsa006501.44189310
23Propanoate metabolism_Homo sapiens_hsa006401.40625886
24Base excision repair_Homo sapiens_hsa034101.39403439
25Nucleotide excision repair_Homo sapiens_hsa034201.37197703
26Sulfur relay system_Homo sapiens_hsa041221.36332181
27Pyrimidine metabolism_Homo sapiens_hsa002401.32771376
28Steroid biosynthesis_Homo sapiens_hsa001001.28314702
29Spliceosome_Homo sapiens_hsa030401.27031605
30Collecting duct acid secretion_Homo sapiens_hsa049661.25805455
31Glutathione metabolism_Homo sapiens_hsa004801.25346588
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.24277837
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.17065990
34Pyruvate metabolism_Homo sapiens_hsa006201.16022477
35Phototransduction_Homo sapiens_hsa047441.11948698
36Basal transcription factors_Homo sapiens_hsa030221.10529325
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.09100961
38Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.05670542
39RNA degradation_Homo sapiens_hsa030181.05627481
40Purine metabolism_Homo sapiens_hsa002301.03157156
41Peroxisome_Homo sapiens_hsa041461.03125254
42One carbon pool by folate_Homo sapiens_hsa006701.01120990
43Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.00536263
44Sulfur metabolism_Homo sapiens_hsa009200.92183504
45Metabolic pathways_Homo sapiens_hsa011000.91776852
46Nicotine addiction_Homo sapiens_hsa050330.83284493
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.83001108
48RNA transport_Homo sapiens_hsa030130.82172013
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.81501907
502-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.75608827
51Carbon metabolism_Homo sapiens_hsa012000.75342066
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69209443
53Synaptic vesicle cycle_Homo sapiens_hsa047210.66375764
54Vibrio cholerae infection_Homo sapiens_hsa051100.66330696
55Primary bile acid biosynthesis_Homo sapiens_hsa001200.65700794
56Selenocompound metabolism_Homo sapiens_hsa004500.64761643
57Chemical carcinogenesis_Homo sapiens_hsa052040.64476367
58Non-homologous end-joining_Homo sapiens_hsa034500.61849946
59Maturity onset diabetes of the young_Homo sapiens_hsa049500.61576409
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61449076
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60251660
62Fatty acid metabolism_Homo sapiens_hsa012120.59365316
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58130263
64Biosynthesis of amino acids_Homo sapiens_hsa012300.57659582
65Cell cycle_Homo sapiens_hsa041100.56502719
66N-Glycan biosynthesis_Homo sapiens_hsa005100.56044016
67Hedgehog signaling pathway_Homo sapiens_hsa043400.55460524
68Tryptophan metabolism_Homo sapiens_hsa003800.53531710
69Nitrogen metabolism_Homo sapiens_hsa009100.52626556
70Basal cell carcinoma_Homo sapiens_hsa052170.52579866
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48742039
72GABAergic synapse_Homo sapiens_hsa047270.48496519
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46721215
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46494069
75Arginine and proline metabolism_Homo sapiens_hsa003300.44471655
76Oocyte meiosis_Homo sapiens_hsa041140.44302824
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44011136
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42994090
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42685013
80Alcoholism_Homo sapiens_hsa050340.41480908
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40135751
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40015310
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38469389
84Olfactory transduction_Homo sapiens_hsa047400.37173521
85Morphine addiction_Homo sapiens_hsa050320.34448875
86Regulation of autophagy_Homo sapiens_hsa041400.33254860
87Fatty acid degradation_Homo sapiens_hsa000710.32472916
88beta-Alanine metabolism_Homo sapiens_hsa004100.32000501
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.31511139
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.31403052
91Vitamin B6 metabolism_Homo sapiens_hsa007500.31129052
92Linoleic acid metabolism_Homo sapiens_hsa005910.30665378
93alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28919873
94Galactose metabolism_Homo sapiens_hsa000520.28775940
95Fat digestion and absorption_Homo sapiens_hsa049750.27733224
96Retinol metabolism_Homo sapiens_hsa008300.26823514
97Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.25268263
98Tyrosine metabolism_Homo sapiens_hsa003500.24770454
99Taste transduction_Homo sapiens_hsa047420.24758312
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.20746036

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