

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 6.80691737 |
| 2 | ATP synthesis coupled proton transport (GO:0015986) | 6.03422310 |
| 3 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 6.03422310 |
| 4 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 5.82317761 |
| 5 | respiratory electron transport chain (GO:0022904) | 5.43531153 |
| 6 | electron transport chain (GO:0022900) | 5.32057673 |
| 7 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.89215517 |
| 8 | protein neddylation (GO:0045116) | 4.86769966 |
| 9 | protein complex biogenesis (GO:0070271) | 4.79523060 |
| 10 | chaperone-mediated protein transport (GO:0072321) | 4.47675970 |
| 11 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.42440931 |
| 12 | NADH dehydrogenase complex assembly (GO:0010257) | 4.34257651 |
| 13 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.34257651 |
| 14 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.34257651 |
| 15 | regulation of mitochondrial translation (GO:0070129) | 4.01439947 |
| 16 | proteasome assembly (GO:0043248) | 4.00980131 |
| 17 | viral transcription (GO:0019083) | 3.98865845 |
| 18 | sequestering of actin monomers (GO:0042989) | 3.95689197 |
| 19 | translational termination (GO:0006415) | 3.94553777 |
| 20 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.86903723 |
| 21 | cotranslational protein targeting to membrane (GO:0006613) | 3.85632572 |
| 22 | ribosomal small subunit assembly (GO:0000028) | 3.81609637 |
| 23 | protein targeting to ER (GO:0045047) | 3.78642169 |
| 24 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.67114723 |
| 25 | respiratory chain complex IV assembly (GO:0008535) | 3.61171536 |
| 26 | protein localization to endoplasmic reticulum (GO:0070972) | 3.60152989 |
| 27 | hydrogen ion transmembrane transport (GO:1902600) | 3.58486993 |
| 28 | ATP biosynthetic process (GO:0006754) | 3.53107086 |
| 29 | inner mitochondrial membrane organization (GO:0007007) | 3.49627209 |
| 30 | chromatin remodeling at centromere (GO:0031055) | 3.38325652 |
| 31 | cullin deneddylation (GO:0010388) | 3.34808890 |
| 32 | cytochrome complex assembly (GO:0017004) | 3.34191386 |
| 33 | translational elongation (GO:0006414) | 3.33148370 |
| 34 | nonmotile primary cilium assembly (GO:0035058) | 3.26465448 |
| 35 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.25460198 |
| 36 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.24734433 |
| 37 | CENP-A containing nucleosome assembly (GO:0034080) | 3.20618688 |
| 38 | proton transport (GO:0015992) | 3.19576174 |
| 39 | protein-cofactor linkage (GO:0018065) | 3.18342987 |
| 40 | regulation of cilium movement (GO:0003352) | 3.17384553 |
| 41 | maturation of SSU-rRNA (GO:0030490) | 3.15039635 |
| 42 | viral life cycle (GO:0019058) | 3.12301133 |
| 43 | termination of RNA polymerase III transcription (GO:0006386) | 3.11733501 |
| 44 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.11733501 |
| 45 | hydrogen transport (GO:0006818) | 3.11698648 |
| 46 | protein deneddylation (GO:0000338) | 3.11508383 |
| 47 | oxidative phosphorylation (GO:0006119) | 3.09614150 |
| 48 | cellular protein complex disassembly (GO:0043624) | 3.09418811 |
| 49 | ribosomal small subunit biogenesis (GO:0042274) | 3.08662947 |
| 50 | protein targeting to mitochondrion (GO:0006626) | 3.04911906 |
| 51 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.04192307 |
| 52 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.04081201 |
| 53 | establishment of protein localization to mitochondrion (GO:0072655) | 3.01800734 |
| 54 | epithelial cilium movement (GO:0003351) | 2.99374385 |
| 55 | protein localization to mitochondrion (GO:0070585) | 2.96815161 |
| 56 | translation (GO:0006412) | 2.95472502 |
| 57 | platelet dense granule organization (GO:0060155) | 2.91347684 |
| 58 | peptidyl-histidine modification (GO:0018202) | 2.91313992 |
| 59 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 2.89094276 |
| 60 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 2.89080214 |
| 61 | ribosomal large subunit biogenesis (GO:0042273) | 2.87146543 |
| 62 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 2.86641585 |
| 63 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 2.82877624 |
| 64 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 2.82398876 |
| 65 | translational initiation (GO:0006413) | 2.81577608 |
| 66 | aldehyde catabolic process (GO:0046185) | 2.79620249 |
| 67 | behavioral response to nicotine (GO:0035095) | 2.78168447 |
| 68 | intraciliary transport (GO:0042073) | 2.77412511 |
| 69 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 2.74451106 |
| 70 | negative regulation of ligase activity (GO:0051352) | 2.74451106 |
| 71 | nucleoside triphosphate biosynthetic process (GO:0009142) | 2.69380058 |
| 72 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 2.69203562 |
| 73 | kinetochore assembly (GO:0051382) | 2.69187285 |
| 74 | intracellular protein transmembrane import (GO:0044743) | 2.69012516 |
| 75 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 2.68965730 |
| 76 | protein complex disassembly (GO:0043241) | 2.68248277 |
| 77 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 2.66644121 |
| 78 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 2.66644121 |
| 79 | regulation of cellular amino acid metabolic process (GO:0006521) | 2.64996797 |
| 80 | DNA damage response, detection of DNA damage (GO:0042769) | 2.64284295 |
| 81 | spliceosomal snRNP assembly (GO:0000387) | 2.63851299 |
| 82 | cellular component biogenesis (GO:0044085) | 2.61810371 |
| 83 | mitochondrial transport (GO:0006839) | 2.61318498 |
| 84 | mannosylation (GO:0097502) | 2.61273738 |
| 85 | macromolecular complex disassembly (GO:0032984) | 2.59873409 |
| 86 | 7-methylguanosine mRNA capping (GO:0006370) | 2.58537927 |
| 87 | epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287) | 2.58057896 |
| 88 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 2.56179421 |
| 89 | substrate-independent telencephalic tangential interneuron migration (GO:0021843) | 2.55568507 |
| 90 | substrate-independent telencephalic tangential migration (GO:0021826) | 2.55568507 |
| 91 | negative regulation of appetite (GO:0032099) | 2.55070640 |
| 92 | negative regulation of response to food (GO:0032096) | 2.55070640 |
| 93 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.51795771 |
| 94 | 7-methylguanosine RNA capping (GO:0009452) | 2.50780267 |
| 95 | RNA capping (GO:0036260) | 2.50780267 |
| 96 | ubiquinone biosynthetic process (GO:0006744) | 2.49461178 |
| 97 | anterograde synaptic vesicle transport (GO:0048490) | 2.48114181 |
| 98 | histone exchange (GO:0043486) | 2.47102663 |
| 99 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.46928860 |
| 100 | protein targeting to membrane (GO:0006612) | 2.46488492 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.80594919 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.23456008 |
| 3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.07224213 |
| 4 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.39463234 |
| 5 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.38921938 |
| 6 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.33072334 |
| 7 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.18226260 |
| 8 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.15853541 |
| 9 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.11620592 |
| 10 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.83229998 |
| 11 | EZH2_22144423_ChIP-Seq_EOC_Human | 2.66154335 |
| 12 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.62029609 |
| 13 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 2.59814255 |
| 14 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.50585749 |
| 15 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.29976506 |
| 16 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.28440648 |
| 17 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.25171887 |
| 18 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.17441306 |
| 19 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.16133278 |
| 20 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.12243323 |
| 21 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.09120418 |
| 22 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.98376566 |
| 23 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.87539678 |
| 24 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.86440131 |
| 25 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.86287185 |
| 26 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.85911937 |
| 27 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.84264891 |
| 28 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.80498343 |
| 29 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.79001427 |
| 30 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.77038429 |
| 31 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.76820852 |
| 32 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.76358259 |
| 33 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.74663238 |
| 34 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.69455410 |
| 35 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.64394164 |
| 36 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.58226160 |
| 37 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.53322434 |
| 38 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.52414309 |
| 39 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.51777249 |
| 40 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.48214934 |
| 41 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.46659938 |
| 42 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.46118239 |
| 43 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.45500043 |
| 44 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.44836409 |
| 45 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.44122319 |
| 46 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.40071085 |
| 47 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.37449691 |
| 48 | FUS_26573619_Chip-Seq_HEK293_Human | 1.34890667 |
| 49 | EWS_26573619_Chip-Seq_HEK293_Human | 1.33960207 |
| 50 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.31390526 |
| 51 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.29853768 |
| 52 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.26006369 |
| 53 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.25661848 |
| 54 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.24668547 |
| 55 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.23026960 |
| 56 | VDR_22108803_ChIP-Seq_LS180_Human | 1.21744809 |
| 57 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.19647794 |
| 58 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.19508970 |
| 59 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.17585419 |
| 60 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.16224091 |
| 61 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.14698132 |
| 62 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.14159009 |
| 63 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.13895284 |
| 64 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.12927660 |
| 65 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.12617455 |
| 66 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.11726825 |
| 67 | * SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 1.11337891 |
| 68 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.10755662 |
| 69 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.10574777 |
| 70 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.07431002 |
| 71 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.05145454 |
| 72 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.04831688 |
| 73 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.04740753 |
| 74 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.04254524 |
| 75 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.03578072 |
| 76 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.02538249 |
| 77 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.95916423 |
| 78 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 0.92726911 |
| 79 | RNF2_27304074_Chip-Seq_NSC_Mouse | 0.92630423 |
| 80 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 0.92198392 |
| 81 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.91802911 |
| 82 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 0.90173303 |
| 83 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.90143736 |
| 84 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.90120995 |
| 85 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.90091733 |
| 86 | P300_19829295_ChIP-Seq_ESCs_Human | 0.89271766 |
| 87 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.89258192 |
| 88 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.88960022 |
| 89 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.87723945 |
| 90 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.87569514 |
| 91 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.87377886 |
| 92 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.86135051 |
| 93 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 0.83280671 |
| 94 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.82722699 |
| 95 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 0.82266833 |
| 96 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.81756715 |
| 97 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.80017216 |
| 98 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 0.79906506 |
| 99 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 0.78534881 |
| 100 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 0.77705180 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003136_yellow_coat_color | 3.07020749 |
| 2 | MP0009379_abnormal_foot_pigmentation | 2.60408425 |
| 3 | MP0006292_abnormal_olfactory_placode | 2.52571841 |
| 4 | MP0003123_paternal_imprinting | 2.42332175 |
| 5 | MP0003122_maternal_imprinting | 2.34451070 |
| 6 | MP0003880_abnormal_central_pattern | 2.32875062 |
| 7 | MP0008789_abnormal_olfactory_epithelium | 2.23327882 |
| 8 | MP0003121_genomic_imprinting | 2.22175479 |
| 9 | MP0001984_abnormal_olfaction | 2.19916762 |
| 10 | MP0001529_abnormal_vocalization | 2.18499019 |
| 11 | MP0002653_abnormal_ependyma_morphology | 2.07789852 |
| 12 | MP0005499_abnormal_olfactory_system | 2.07105835 |
| 13 | MP0005394_taste/olfaction_phenotype | 2.07105835 |
| 14 | MP0003011_delayed_dark_adaptation | 2.05159567 |
| 15 | MP0002938_white_spotting | 2.00891801 |
| 16 | MP0006072_abnormal_retinal_apoptosis | 1.98764485 |
| 17 | MP0002638_abnormal_pupillary_reflex | 1.97204538 |
| 18 | MP0008995_early_reproductive_senescence | 1.95240757 |
| 19 | MP0008877_abnormal_DNA_methylation | 1.95186263 |
| 20 | MP0003186_abnormal_redox_activity | 1.94306718 |
| 21 | MP0002822_catalepsy | 1.88267148 |
| 22 | MP0000372_irregular_coat_pigmentation | 1.87903261 |
| 23 | MP0006276_abnormal_autonomic_nervous | 1.85235223 |
| 24 | MP0002837_dystrophic_cardiac_calcinosis | 1.77404263 |
| 25 | MP0008058_abnormal_DNA_repair | 1.76211605 |
| 26 | MP0002736_abnormal_nociception_after | 1.71188734 |
| 27 | MP0004142_abnormal_muscle_tone | 1.71025177 |
| 28 | MP0009046_muscle_twitch | 1.70179657 |
| 29 | MP0010030_abnormal_orbit_morphology | 1.63354634 |
| 30 | MP0005423_abnormal_somatic_nervous | 1.59636205 |
| 31 | MP0005551_abnormal_eye_electrophysiolog | 1.58452865 |
| 32 | MP0001968_abnormal_touch/_nociception | 1.54416660 |
| 33 | MP0004133_heterotaxia | 1.52107097 |
| 34 | MP0001293_anophthalmia | 1.49248742 |
| 35 | MP0003787_abnormal_imprinting | 1.48420373 |
| 36 | MP0003786_premature_aging | 1.43645848 |
| 37 | MP0006036_abnormal_mitochondrial_physio | 1.39988481 |
| 38 | MP0000631_abnormal_neuroendocrine_gland | 1.38827359 |
| 39 | MP0002102_abnormal_ear_morphology | 1.37823637 |
| 40 | MP0005253_abnormal_eye_physiology | 1.36552171 |
| 41 | MP0002272_abnormal_nervous_system | 1.35781036 |
| 42 | MP0001905_abnormal_dopamine_level | 1.35738609 |
| 43 | MP0001188_hyperpigmentation | 1.31004259 |
| 44 | MP0002160_abnormal_reproductive_system | 1.30391137 |
| 45 | MP0008932_abnormal_embryonic_tissue | 1.28135611 |
| 46 | MP0002234_abnormal_pharynx_morphology | 1.26682001 |
| 47 | MP0006035_abnormal_mitochondrial_morpho | 1.26659204 |
| 48 | MP0005171_absent_coat_pigmentation | 1.26457910 |
| 49 | MP0002557_abnormal_social/conspecific_i | 1.21977605 |
| 50 | MP0000778_abnormal_nervous_system | 1.21058499 |
| 51 | MP0005084_abnormal_gallbladder_morpholo | 1.20187334 |
| 52 | MP0000566_synostosis | 1.19127951 |
| 53 | MP0002734_abnormal_mechanical_nocicepti | 1.18165306 |
| 54 | MP0009745_abnormal_behavioral_response | 1.17230436 |
| 55 | MP0010094_abnormal_chromosome_stability | 1.14351484 |
| 56 | MP0002735_abnormal_chemical_nociception | 1.13707222 |
| 57 | MP0005389_reproductive_system_phenotype | 1.13178387 |
| 58 | MP0003693_abnormal_embryo_hatching | 1.10916017 |
| 59 | MP0003718_maternal_effect | 1.09456832 |
| 60 | MP0002210_abnormal_sex_determination | 1.09068103 |
| 61 | MP0003890_abnormal_embryonic-extraembry | 1.05994220 |
| 62 | MP0001970_abnormal_pain_threshold | 1.02806079 |
| 63 | MP0001919_abnormal_reproductive_system | 0.99140594 |
| 64 | MP0004957_abnormal_blastocyst_morpholog | 0.99058586 |
| 65 | MP0000049_abnormal_middle_ear | 0.98593292 |
| 66 | MP0005195_abnormal_posterior_eye | 0.97929845 |
| 67 | MP0002752_abnormal_somatic_nervous | 0.97540600 |
| 68 | MP0001485_abnormal_pinna_reflex | 0.96614335 |
| 69 | MP0003315_abnormal_perineum_morphology | 0.96119808 |
| 70 | MP0002095_abnormal_skin_pigmentation | 0.95567715 |
| 71 | MP0002572_abnormal_emotion/affect_behav | 0.94829692 |
| 72 | MP0002233_abnormal_nose_morphology | 0.94691646 |
| 73 | MP0002163_abnormal_gland_morphology | 0.94127786 |
| 74 | MP0002909_abnormal_adrenal_gland | 0.93621099 |
| 75 | MP0001986_abnormal_taste_sensitivity | 0.92585554 |
| 76 | MP0002733_abnormal_thermal_nociception | 0.92525094 |
| 77 | MP0001286_abnormal_eye_development | 0.92193637 |
| 78 | MP0005391_vision/eye_phenotype | 0.90775704 |
| 79 | MP0004147_increased_porphyrin_level | 0.90595528 |
| 80 | MP0004145_abnormal_muscle_electrophysio | 0.90400937 |
| 81 | MP0009697_abnormal_copulation | 0.89368946 |
| 82 | MP0005646_abnormal_pituitary_gland | 0.89198307 |
| 83 | MP0001764_abnormal_homeostasis | 0.87826235 |
| 84 | MP0001324_abnormal_eye_pigmentation | 0.87411670 |
| 85 | MP0003698_abnormal_male_reproductive | 0.86402495 |
| 86 | MP0000653_abnormal_sex_gland | 0.85999978 |
| 87 | MP0001299_abnormal_eye_distance/ | 0.85653559 |
| 88 | MP0001145_abnormal_male_reproductive | 0.85248268 |
| 89 | MP0003195_calcinosis | 0.84894019 |
| 90 | MP0001486_abnormal_startle_reflex | 0.84420954 |
| 91 | MP0001929_abnormal_gametogenesis | 0.83862808 |
| 92 | MP0000026_abnormal_inner_ear | 0.83532006 |
| 93 | MP0002090_abnormal_vision | 0.82047592 |
| 94 | MP0002067_abnormal_sensory_capabilities | 0.81905581 |
| 95 | MP0005645_abnormal_hypothalamus_physiol | 0.81690672 |
| 96 | MP0005187_abnormal_penis_morphology | 0.81325102 |
| 97 | MP0003806_abnormal_nucleotide_metabolis | 0.81292541 |
| 98 | MP0003942_abnormal_urinary_system | 0.81161128 |
| 99 | MP0002882_abnormal_neuron_morphology | 0.81003805 |
| 100 | MP0000358_abnormal_cell_content/ | 0.79928973 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 5.55742411 |
| 2 | Abnormal mitochondria in muscle tissue (HP:0008316) | 5.28396266 |
| 3 | Mitochondrial inheritance (HP:0001427) | 5.02773882 |
| 4 | Acute encephalopathy (HP:0006846) | 4.99731773 |
| 5 | Progressive macrocephaly (HP:0004481) | 4.60689152 |
| 6 | Hepatocellular necrosis (HP:0001404) | 4.43252772 |
| 7 | Increased CSF lactate (HP:0002490) | 4.30189351 |
| 8 | Hepatic necrosis (HP:0002605) | 4.20064096 |
| 9 | Increased hepatocellular lipid droplets (HP:0006565) | 3.76531979 |
| 10 | Renal Fanconi syndrome (HP:0001994) | 3.55968397 |
| 11 | Cerebral edema (HP:0002181) | 3.54948512 |
| 12 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.50525405 |
| 13 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.50525405 |
| 14 | Abnormal number of erythroid precursors (HP:0012131) | 3.49818039 |
| 15 | Reticulocytopenia (HP:0001896) | 3.47426262 |
| 16 | Lipid accumulation in hepatocytes (HP:0006561) | 3.42079435 |
| 17 | Abnormality of cells of the erythroid lineage (HP:0012130) | 3.39513057 |
| 18 | Medial flaring of the eyebrow (HP:0010747) | 3.23930443 |
| 19 | Increased intramyocellular lipid droplets (HP:0012240) | 3.07741254 |
| 20 | Pancreatic fibrosis (HP:0100732) | 3.03491432 |
| 21 | 3-Methylglutaconic aciduria (HP:0003535) | 2.99272104 |
| 22 | Gait imbalance (HP:0002141) | 2.98078763 |
| 23 | Congenital primary aphakia (HP:0007707) | 2.92624075 |
| 24 | True hermaphroditism (HP:0010459) | 2.87330782 |
| 25 | Molar tooth sign on MRI (HP:0002419) | 2.85721448 |
| 26 | Abnormality of midbrain morphology (HP:0002418) | 2.85721448 |
| 27 | Lactic acidosis (HP:0003128) | 2.85083680 |
| 28 | Respiratory failure (HP:0002878) | 2.84657599 |
| 29 | Pancreatic cysts (HP:0001737) | 2.74742332 |
| 30 | Optic disc pallor (HP:0000543) | 2.70341226 |
| 31 | Nephrogenic diabetes insipidus (HP:0009806) | 2.66702137 |
| 32 | Myokymia (HP:0002411) | 2.63884006 |
| 33 | Exercise intolerance (HP:0003546) | 2.63846477 |
| 34 | Increased serum lactate (HP:0002151) | 2.59012695 |
| 35 | Increased muscle lipid content (HP:0009058) | 2.52481419 |
| 36 | Sclerocornea (HP:0000647) | 2.41033712 |
| 37 | Macrocytic anemia (HP:0001972) | 2.37157140 |
| 38 | Hyperglycinemia (HP:0002154) | 2.36468448 |
| 39 | Genital tract atresia (HP:0001827) | 2.34643524 |
| 40 | Leukodystrophy (HP:0002415) | 2.32990119 |
| 41 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.32956522 |
| 42 | Exertional dyspnea (HP:0002875) | 2.31257034 |
| 43 | Vaginal atresia (HP:0000148) | 2.31219143 |
| 44 | Abnormality of the anterior horn cell (HP:0006802) | 2.28990912 |
| 45 | Degeneration of anterior horn cells (HP:0002398) | 2.28990912 |
| 46 | Glycosuria (HP:0003076) | 2.26321365 |
| 47 | Abnormality of urine glucose concentration (HP:0011016) | 2.26321365 |
| 48 | X-linked dominant inheritance (HP:0001423) | 2.26024645 |
| 49 | Respiratory difficulties (HP:0002880) | 2.21777167 |
| 50 | Male pseudohermaphroditism (HP:0000037) | 2.21138873 |
| 51 | Nephronophthisis (HP:0000090) | 2.20846190 |
| 52 | Abnormality of the labia minora (HP:0012880) | 2.20596644 |
| 53 | Abnormal respiratory motile cilium morphology (HP:0005938) | 2.20134029 |
| 54 | Abnormal respiratory epithelium morphology (HP:0012253) | 2.20134029 |
| 55 | Generalized aminoaciduria (HP:0002909) | 2.19313247 |
| 56 | Abnormality of renal resorption (HP:0011038) | 2.17960022 |
| 57 | Septo-optic dysplasia (HP:0100842) | 2.10791436 |
| 58 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.10202977 |
| 59 | Lethargy (HP:0001254) | 2.09243202 |
| 60 | Polyphagia (HP:0002591) | 2.02662545 |
| 61 | CNS demyelination (HP:0007305) | 2.02527521 |
| 62 | Short tibia (HP:0005736) | 1.98435798 |
| 63 | Increased serum pyruvate (HP:0003542) | 1.96286172 |
| 64 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 1.93052875 |
| 65 | Supernumerary spleens (HP:0009799) | 1.92754789 |
| 66 | Emotional lability (HP:0000712) | 1.90661261 |
| 67 | Abnormal respiratory motile cilium physiology (HP:0012261) | 1.90426770 |
| 68 | Hyperphosphaturia (HP:0003109) | 1.88856823 |
| 69 | Anencephaly (HP:0002323) | 1.88101112 |
| 70 | Decreased testicular size (HP:0008734) | 1.86648190 |
| 71 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 1.85264010 |
| 72 | Poor coordination (HP:0002370) | 1.84900914 |
| 73 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 1.84756961 |
| 74 | Abnormal ciliary motility (HP:0012262) | 1.84445513 |
| 75 | Occipital encephalocele (HP:0002085) | 1.83171611 |
| 76 | Adrenal hypoplasia (HP:0000835) | 1.80560759 |
| 77 | Methylmalonic aciduria (HP:0012120) | 1.79131836 |
| 78 | Aganglionic megacolon (HP:0002251) | 1.78555309 |
| 79 | Retinal dysplasia (HP:0007973) | 1.77094780 |
| 80 | Anophthalmia (HP:0000528) | 1.75601180 |
| 81 | Absent septum pellucidum (HP:0001331) | 1.74269279 |
| 82 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.72005643 |
| 83 | Abnormality of glycolysis (HP:0004366) | 1.71550951 |
| 84 | Preaxial hand polydactyly (HP:0001177) | 1.70296021 |
| 85 | Meckel diverticulum (HP:0002245) | 1.70111388 |
| 86 | Blindness (HP:0000618) | 1.68834468 |
| 87 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.67564284 |
| 88 | Colon cancer (HP:0003003) | 1.67299387 |
| 89 | Pallor (HP:0000980) | 1.67041235 |
| 90 | Type II lissencephaly (HP:0007260) | 1.66254857 |
| 91 | Aplastic anemia (HP:0001915) | 1.65838266 |
| 92 | Absent thumb (HP:0009777) | 1.65709965 |
| 93 | Rib fusion (HP:0000902) | 1.65697328 |
| 94 | Optic nerve hypoplasia (HP:0000609) | 1.65514428 |
| 95 | Hypoplastic pelvis (HP:0008839) | 1.65022284 |
| 96 | Poor suck (HP:0002033) | 1.64244141 |
| 97 | Methylmalonic acidemia (HP:0002912) | 1.63291699 |
| 98 | Congenital, generalized hypertrichosis (HP:0004540) | 1.61495370 |
| 99 | Postaxial hand polydactyly (HP:0001162) | 1.61334619 |
| 100 | Triphalangeal thumb (HP:0001199) | 1.61166478 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 3.35652004 |
| 2 | ZAK | 2.85181235 |
| 3 | STK16 | 2.75376129 |
| 4 | BCKDK | 2.70640757 |
| 5 | WNK3 | 2.40083003 |
| 6 | BUB1 | 2.39274935 |
| 7 | CASK | 2.35651704 |
| 8 | CDC7 | 2.34136645 |
| 9 | MAP4K2 | 2.17262275 |
| 10 | BMPR1B | 2.07571844 |
| 11 | DYRK2 | 2.00896704 |
| 12 | EPHB2 | 1.94977008 |
| 13 | MAP2K7 | 1.91943536 |
| 14 | MAP3K4 | 1.76979311 |
| 15 | PLK4 | 1.74191471 |
| 16 | VRK1 | 1.73331342 |
| 17 | SRPK1 | 1.57110358 |
| 18 | NME2 | 1.56273206 |
| 19 | TNIK | 1.53600424 |
| 20 | NME1 | 1.53039306 |
| 21 | PDK2 | 1.48972098 |
| 22 | CSNK1G3 | 1.47480064 |
| 23 | NEK1 | 1.46457069 |
| 24 | LIMK1 | 1.42617498 |
| 25 | CSNK1G2 | 1.42151714 |
| 26 | PLK3 | 1.41753875 |
| 27 | INSRR | 1.41162842 |
| 28 | NUAK1 | 1.38368796 |
| 29 | EIF2AK1 | 1.35637457 |
| 30 | PLK2 | 1.30943973 |
| 31 | MARK1 | 1.30391974 |
| 32 | EPHA4 | 1.29195598 |
| 33 | TESK2 | 1.26291642 |
| 34 | CSNK1G1 | 1.24925414 |
| 35 | MAPK13 | 1.23670032 |
| 36 | PIM2 | 1.22645127 |
| 37 | TRIM28 | 1.22343485 |
| 38 | PLK1 | 1.20994191 |
| 39 | GRK1 | 1.20214780 |
| 40 | DYRK3 | 1.19730820 |
| 41 | WEE1 | 1.18937184 |
| 42 | BCR | 1.18678484 |
| 43 | TLK1 | 1.18406623 |
| 44 | TESK1 | 1.16594023 |
| 45 | MST4 | 1.16249545 |
| 46 | BRSK1 | 1.15858088 |
| 47 | CCNB1 | 1.12966175 |
| 48 | PBK | 1.11336529 |
| 49 | CSNK1A1L | 1.10496512 |
| 50 | TTK | 1.07939047 |
| 51 | ADRBK2 | 1.06949639 |
| 52 | PRKCG | 1.00123508 |
| 53 | MUSK | 0.96810646 |
| 54 | PINK1 | 0.96378471 |
| 55 | AURKA | 0.93797353 |
| 56 | FRK | 0.91706208 |
| 57 | MINK1 | 0.91067914 |
| 58 | NTRK2 | 0.89917249 |
| 59 | BRSK2 | 0.88636766 |
| 60 | CDK19 | 0.82546298 |
| 61 | MAP3K12 | 0.78182707 |
| 62 | PHKG2 | 0.76215617 |
| 63 | PHKG1 | 0.76215617 |
| 64 | LRRK2 | 0.73977202 |
| 65 | CHEK2 | 0.72747364 |
| 66 | ABL2 | 0.72631578 |
| 67 | PAK3 | 0.70961812 |
| 68 | AURKB | 0.70006568 |
| 69 | MKNK2 | 0.69683164 |
| 70 | PNCK | 0.68064327 |
| 71 | ARAF | 0.66424090 |
| 72 | NTRK3 | 0.66416279 |
| 73 | RPS6KA5 | 0.66331602 |
| 74 | WNK4 | 0.65577165 |
| 75 | PRKCE | 0.64899654 |
| 76 | ATR | 0.63080374 |
| 77 | CDK8 | 0.62804466 |
| 78 | CDK14 | 0.62146440 |
| 79 | CSNK2A1 | 0.59210938 |
| 80 | PKN1 | 0.59184874 |
| 81 | CSNK2A2 | 0.58325713 |
| 82 | MKNK1 | 0.56711252 |
| 83 | MAP3K11 | 0.55477332 |
| 84 | GRK5 | 0.55321622 |
| 85 | BRAF | 0.53482266 |
| 86 | CDK11A | 0.53068376 |
| 87 | CDK18 | 0.51722224 |
| 88 | CDK15 | 0.50140928 |
| 89 | ERBB3 | 0.50054027 |
| 90 | STK38L | 0.49770035 |
| 91 | ADRBK1 | 0.49200998 |
| 92 | DAPK3 | 0.48757891 |
| 93 | CAMK2A | 0.47977319 |
| 94 | EIF2AK3 | 0.47179478 |
| 95 | CSNK1E | 0.46226461 |
| 96 | PRKACA | 0.44982493 |
| 97 | CSNK1A1 | 0.43423373 |
| 98 | FGFR2 | 0.43250312 |
| 99 | PAK1 | 0.43086108 |
| 100 | DYRK1A | 0.41008354 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 4.80047695 |
| 2 | Parkinsons disease_Homo sapiens_hsa05012 | 4.12402278 |
| 3 | Ribosome_Homo sapiens_hsa03010 | 3.55627201 |
| 4 | Proteasome_Homo sapiens_hsa03050 | 3.04444084 |
| 5 | Huntingtons disease_Homo sapiens_hsa05016 | 2.98367973 |
| 6 | Protein export_Homo sapiens_hsa03060 | 2.92521673 |
| 7 | Alzheimers disease_Homo sapiens_hsa05010 | 2.80105232 |
| 8 | RNA polymerase_Homo sapiens_hsa03020 | 2.48298680 |
| 9 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.33714105 |
| 10 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.19916543 |
| 11 | Mismatch repair_Homo sapiens_hsa03430 | 2.16961287 |
| 12 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 2.10704454 |
| 13 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 2.01666194 |
| 14 | DNA replication_Homo sapiens_hsa03030 | 1.96714457 |
| 15 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.96428635 |
| 16 | Homologous recombination_Homo sapiens_hsa03440 | 1.89530264 |
| 17 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.85200047 |
| 18 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.68962572 |
| 19 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.66953904 |
| 20 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.55480198 |
| 21 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.54450080 |
| 22 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.44189310 |
| 23 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.40625886 |
| 24 | Base excision repair_Homo sapiens_hsa03410 | 1.39403439 |
| 25 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.37197703 |
| 26 | Sulfur relay system_Homo sapiens_hsa04122 | 1.36332181 |
| 27 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.32771376 |
| 28 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.28314702 |
| 29 | Spliceosome_Homo sapiens_hsa03040 | 1.27031605 |
| 30 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.25805455 |
| 31 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.25346588 |
| 32 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.24277837 |
| 33 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 1.17065990 |
| 34 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.16022477 |
| 35 | Phototransduction_Homo sapiens_hsa04744 | 1.11948698 |
| 36 | Basal transcription factors_Homo sapiens_hsa03022 | 1.10529325 |
| 37 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.09100961 |
| 38 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.05670542 |
| 39 | RNA degradation_Homo sapiens_hsa03018 | 1.05627481 |
| 40 | Purine metabolism_Homo sapiens_hsa00230 | 1.03157156 |
| 41 | Peroxisome_Homo sapiens_hsa04146 | 1.03125254 |
| 42 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.01120990 |
| 43 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.00536263 |
| 44 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.92183504 |
| 45 | Metabolic pathways_Homo sapiens_hsa01100 | 0.91776852 |
| 46 | Nicotine addiction_Homo sapiens_hsa05033 | 0.83284493 |
| 47 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.83001108 |
| 48 | RNA transport_Homo sapiens_hsa03013 | 0.82172013 |
| 49 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.81501907 |
| 50 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.75608827 |
| 51 | Carbon metabolism_Homo sapiens_hsa01200 | 0.75342066 |
| 52 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.69209443 |
| 53 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.66375764 |
| 54 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.66330696 |
| 55 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.65700794 |
| 56 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.64761643 |
| 57 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.64476367 |
| 58 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.61849946 |
| 59 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.61576409 |
| 60 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.61449076 |
| 61 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.60251660 |
| 62 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.59365316 |
| 63 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.58130263 |
| 64 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.57659582 |
| 65 | Cell cycle_Homo sapiens_hsa04110 | 0.56502719 |
| 66 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.56044016 |
| 67 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.55460524 |
| 68 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.53531710 |
| 69 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.52626556 |
| 70 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.52579866 |
| 71 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.48742039 |
| 72 | GABAergic synapse_Homo sapiens_hsa04727 | 0.48496519 |
| 73 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.46721215 |
| 74 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.46494069 |
| 75 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.44471655 |
| 76 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.44302824 |
| 77 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.44011136 |
| 78 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.42994090 |
| 79 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.42685013 |
| 80 | Alcoholism_Homo sapiens_hsa05034 | 0.41480908 |
| 81 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.40135751 |
| 82 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.40015310 |
| 83 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.38469389 |
| 84 | Olfactory transduction_Homo sapiens_hsa04740 | 0.37173521 |
| 85 | Morphine addiction_Homo sapiens_hsa05032 | 0.34448875 |
| 86 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.33254860 |
| 87 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.32472916 |
| 88 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.32000501 |
| 89 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.31511139 |
| 90 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.31403052 |
| 91 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.31129052 |
| 92 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.30665378 |
| 93 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.28919873 |
| 94 | Galactose metabolism_Homo sapiens_hsa00052 | 0.28775940 |
| 95 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.27733224 |
| 96 | Retinol metabolism_Homo sapiens_hsa00830 | 0.26823514 |
| 97 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.25268263 |
| 98 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.24770454 |
| 99 | Taste transduction_Homo sapiens_hsa04742 | 0.24758312 |
| 100 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.20746036 |

