ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	6.06889787
2	protein neddylation (GO:0045116)	5.76457612
3	ATP synthesis coupled proton transport (GO:0015986)	5.61688039
4	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.61688039
5	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	5.53875525
6	protein complex biogenesis (GO:0070271)	5.18229796
7	respiratory electron transport chain (GO:0022904)	5.16048160
8	sequestering of actin monomers (GO:0042989)	5.10575269
9	electron transport chain (GO:0022900)	5.07060280
10	platelet dense granule organization (GO:0060155)	4.76376022
11	mitochondrial respiratory chain complex assembly (GO:0033108)	4.42248315
12	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.23074085
13	DNA deamination (GO:0045006)	4.05003571
14	chaperone-mediated protein transport (GO:0072321)	4.03805918
15	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.03331509
16	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.03331509
17	NADH dehydrogenase complex assembly (GO:0010257)	4.03331509
18	ribosomal small subunit assembly (GO:0000028)	3.98094473
19	cytidine deamination (GO:0009972)	3.97702648
20	cytidine metabolic process (GO:0046087)	3.97702648
21	cytidine catabolic process (GO:0006216)	3.97702648
22	viral transcription (GO:0019083)	3.91326080
23	protein targeting to ER (GO:0045047)	3.73901721
24	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.73896859
25	cotranslational protein targeting to membrane (GO:0006613)	3.71544622
26	protein localization to endoplasmic reticulum (GO:0070972)	3.66384943
27	translational termination (GO:0006415)	3.65700704
28	hydrogen ion transmembrane transport (GO:1902600)	3.62627026
29	eosinophil chemotaxis (GO:0048245)	3.58960606
30	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.57442977
31	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.56945205
32	cytochrome complex assembly (GO:0017004)	3.41271495
33	proton transport (GO:0015992)	3.31670617
34	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.31336797
35	behavioral response to nicotine (GO:0035095)	3.27589985
36	hydrogen transport (GO:0006818)	3.25201225
37	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.22702866
38	eosinophil migration (GO:0072677)	3.19879541
39	positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:00357	3.19078387
40	ATP biosynthetic process (GO:0006754)	3.15770877
41	translational elongation (GO:0006414)	3.13895659
42	positive regulation of TOR signaling (GO:0032008)	3.09508803
43	water-soluble vitamin biosynthetic process (GO:0042364)	3.02863812
44	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.98877230
45	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.98458914
46	viral life cycle (GO:0019058)	2.97521057
47	iron-sulfur cluster assembly (GO:0016226)	2.94634388
48	metallo-sulfur cluster assembly (GO:0031163)	2.94634388
49	ribosomal small subunit biogenesis (GO:0042274)	2.87065151
50	cellular response to zinc ion (GO:0071294)	2.82709809
51	proteasome assembly (GO:0043248)	2.79856528
52	protein maturation by protein folding (GO:0022417)	2.78791242
53	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.77418797
54	cellular protein complex disassembly (GO:0043624)	2.74854106
55	regulation of cilium movement (GO:0003352)	2.74715791
56	deoxyribonucleotide catabolic process (GO:0009264)	2.74245079
57	regulation of mitochondrial translation (GO:0070129)	2.73722606
58	response to interferon-beta (GO:0035456)	2.69535949
59	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.66669071
60	ATP hydrolysis coupled proton transport (GO:0015991)	2.63169369
61	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	2.63169369
62	neuron fate determination (GO:0048664)	2.60703169
63	negative regulation of membrane potential (GO:0045837)	2.60593963
64	positive regulation of T cell apoptotic process (GO:0070234)	2.60538992
65	cellular response to interferon-beta (GO:0035458)	2.60525485
66	positive regulation of lymphocyte apoptotic process (GO:0070230)	2.58413119
67	pyrimidine nucleotide catabolic process (GO:0006244)	2.57296341
68	termination of RNA polymerase III transcription (GO:0006386)	2.56124178
69	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.56124178
70	pyrimidine nucleoside catabolic process (GO:0046135)	2.55827607
71	respiratory chain complex IV assembly (GO:0008535)	2.55041716
72	response to gravity (GO:0009629)	2.54616583
73	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.54526778
74	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.54526778
75	regulation of cellular amino acid metabolic process (GO:0006521)	2.54255247
76	negative regulation of inflammatory response to antigenic stimulus (GO:0002862)	2.53596386
77	macrophage chemotaxis (GO:0048246)	2.52916979
78	mannosylation (GO:0097502)	2.52221794
79	base-excision repair, AP site formation (GO:0006285)	2.51654387
80	GTP biosynthetic process (GO:0006183)	2.45380684
81	deoxyribose phosphate catabolic process (GO:0046386)	2.45216428
82	negative regulation of appetite (GO:0032099)	2.45152433
83	negative regulation of response to food (GO:0032096)	2.45152433
84	inner mitochondrial membrane organization (GO:0007007)	2.43484787
85	protein targeting to membrane (GO:0006612)	2.43431962
86	anterograde synaptic vesicle transport (GO:0048490)	2.43201579
87	viral protein processing (GO:0019082)	2.43156921
88	intracellular protein transmembrane import (GO:0044743)	2.40270550
89	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.38396352
90	negative regulation of cation channel activity (GO:2001258)	2.38037682
91	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	2.37378431
92	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.35992267
93	regulation of mononuclear cell migration (GO:0071675)	2.34413497
94	positive regulation of monocyte chemotaxis (GO:0090026)	2.33897562
95	protein-cofactor linkage (GO:0018065)	2.30706919
96	pyrimidine-containing compound catabolic process (GO:0072529)	2.28775615
97	translation (GO:0006412)	2.28725107
98	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.27830962
99	glycerophospholipid catabolic process (GO:0046475)	2.25962989
100	epithelial cilium movement (GO:0003351)	2.25645884

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.70750122
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.47847286
3	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.13490661
4	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.94227763
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.73711908
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.70743158
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.70325631
8	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	2.65144098
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.50822172
10	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.39893709
11	EZH2_22144423_ChIP-Seq_EOC_Human	2.38042095
12	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.29947763
13	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	2.11156106
14	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.08195929
15	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.07659589
16	SRY_22984422_ChIP-ChIP_TESTIS_Rat	2.02402120
17	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.02060850
18	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.96321582
19	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.88989274
20	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.75898372
21	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.66967927
22	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.66702155
23	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.62269383
24	VDR_23849224_ChIP-Seq_CD4+_Human	1.59918765
25	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.58796975
26	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.57484988
27	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.55289575
28	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.40290577
29	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.39069419
30	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.38772284
31	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.37024008
32	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.36655928
33	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.36066860
34	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.35042115
35	BCL6_27268052_Chip-Seq_Bcells_Human	1.34011402
36	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.33648720
37	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.33616518
38	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.32270076
39	* TAF2_19829295_ChIP-Seq_ESCs_Human	1.29212631
40	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.28514824
41	TP53_22573176_ChIP-Seq_HFKS_Human	1.27561983
42	VDR_22108803_ChIP-Seq_LS180_Human	1.27524166
43	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.26613185
44	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.26086359
45	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.25874785
46	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.25853145
47	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.23927573
48	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.22675768
49	HTT_18923047_ChIP-ChIP_STHdh_Human	1.22486734
50	CTCF_20526341_ChIP-Seq_ESCs_Human	1.21382435
51	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.20503329
52	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.19632363
53	ERG_20517297_ChIP-Seq_VCAP_Human	1.19188566
54	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.18638469
55	NANOG_20526341_ChIP-Seq_ESCs_Human	1.18567849
56	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.18455327
57	ZNF274_21170338_ChIP-Seq_K562_Hela	1.14605858
58	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.14542007
59	MYC_19829295_ChIP-Seq_ESCs_Human	1.14330105
60	STAT1_20625510_ChIP-Seq_HELA_Human	1.11615427
61	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.11106260
62	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	1.10625277
63	REST_21632747_ChIP-Seq_MESCs_Mouse	1.09243250
64	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.08699193
65	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.07845937
66	RAD21_21589869_ChIP-Seq_MESCs_Mouse	1.06833689
67	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.06588763
68	ELK1_19687146_ChIP-ChIP_HELA_Human	1.05297667
69	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.05251898
70	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.05163047
71	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.04446186
72	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.04321479
73	* GATA3_21878914_ChIP-Seq_MCF-7_Human	1.03878622
74	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.03259393
75	AR_20517297_ChIP-Seq_VCAP_Human	1.01979917
76	* FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.99467619
77	* FOXA1_25329375_ChIP-Seq_VCAP_Human	0.99467619
78	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.99072537
79	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.97671289
80	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	0.97560053
81	NCOR_22424771_ChIP-Seq_293T_Human	0.96928407
82	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.96755987
83	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.96550095
84	MYC_18940864_ChIP-ChIP_HL60_Human	0.96490894
85	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.95894652
86	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.95203485
87	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.94918743
88	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.94672888
89	FOXP3_21729870_ChIP-Seq_TREG_Human	0.93981801
90	P300_27268052_Chip-Seq_Bcells_Human	0.93089566
91	SOX2_19829295_ChIP-Seq_ESCs_Human	0.93014001
92	NANOG_19829295_ChIP-Seq_ESCs_Human	0.93014001
93	GBX2_23144817_ChIP-Seq_PC3_Human	0.92971529
94	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.92192730
95	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.90950356
96	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.90821562
97	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.90179387
98	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.89854215
99	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.88965010
100	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.88715455

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002837_dystrophic_cardiac_calcinosis	3.57050108
2	MP0009379_abnormal_foot_pigmentation	3.46286094
3	MP0003011_delayed_dark_adaptation	2.44528589
4	MP0001905_abnormal_dopamine_level	2.38340900
5	MP0003880_abnormal_central_pattern	2.14176512
6	MP0005671_abnormal_response_to	2.12394357
7	MP0003136_yellow_coat_color	2.00805037
8	MP0006082_CNS_inflammation	1.98198527
9	MP0000343_altered_response_to	1.94187361
10	MP0003186_abnormal_redox_activity	1.89400627
11	MP0005084_abnormal_gallbladder_morpholo	1.86466061
12	MP0010386_abnormal_urinary_bladder	1.85811765
13	MP0006072_abnormal_retinal_apoptosis	1.80376742
14	MP0002148_abnormal_hypersensitivity_rea	1.80149772
15	MP0005058_abnormal_lysosome_morphology	1.73695333
16	MP0003806_abnormal_nucleotide_metabolis	1.73279420
17	MP0003122_maternal_imprinting	1.71544633
18	MP0001970_abnormal_pain_threshold	1.69230006
19	MP0001984_abnormal_olfaction	1.68989573
20	MP0002163_abnormal_gland_morphology	1.68720648
21	MP0003123_paternal_imprinting	1.68679327
22	MP0000372_irregular_coat_pigmentation	1.67553528
23	MP0003787_abnormal_imprinting	1.66923177
24	MP0009046_muscle_twitch	1.63138289
25	MP0009785_altered_susceptibility_to	1.56486401
26	MP0004142_abnormal_muscle_tone	1.56414298
27	MP0001542_abnormal_bone_strength	1.56278975
28	MP0002736_abnormal_nociception_after	1.48983087
29	MP0001968_abnormal_touch/_nociception	1.46882272
30	MP0002638_abnormal_pupillary_reflex	1.45621984
31	MP0005646_abnormal_pituitary_gland	1.44866674
32	MP0009745_abnormal_behavioral_response	1.42467315
33	MP0006292_abnormal_olfactory_placode	1.41442321
34	MP0003075_altered_response_to	1.39844978
35	MP0002733_abnormal_thermal_nociception	1.39541626
36	MP0005551_abnormal_eye_electrophysiolog	1.39347194
37	MP0002653_abnormal_ependyma_morphology	1.35734132
38	MP0009764_decreased_sensitivity_to	1.35218710
39	MP0005379_endocrine/exocrine_gland_phen	1.32261303
40	MP0002095_abnormal_skin_pigmentation	1.30743963
41	MP0006276_abnormal_autonomic_nervous	1.30658960
42	MP0004742_abnormal_vestibular_system	1.29550736
43	MP0001485_abnormal_pinna_reflex	1.27538752
44	MP0002272_abnormal_nervous_system	1.23493972
45	MP0005464_abnormal_platelet_physiology	1.23051960
46	MP0002277_abnormal_respiratory_mucosa	1.21982994
47	MP0001529_abnormal_vocalization	1.21706960
48	MP0008789_abnormal_olfactory_epithelium	1.20374345
49	MP0002064_seizures	1.19591446
50	MP0002295_abnormal_pulmonary_circulatio	1.18102967
51	MP0005174_abnormal_tail_pigmentation	1.17581925
52	MP0003121_genomic_imprinting	1.16820858
53	MP0004510_myositis	1.15105273
54	MP0001835_abnormal_antigen_presentation	1.12380333
55	MP0005000_abnormal_immune_tolerance	1.10634603
56	MP0006036_abnormal_mitochondrial_physio	1.10482639
57	MP0005253_abnormal_eye_physiology	1.09915795
58	MP0002938_white_spotting	1.07954148
59	MP0005645_abnormal_hypothalamus_physiol	1.07632400
60	MP0002572_abnormal_emotion/affect_behav	1.07405109
61	MP0002876_abnormal_thyroid_physiology	1.04775001
62	MP0001756_abnormal_urination	1.04369655
63	MP0002735_abnormal_chemical_nociception	1.02053247
64	MP0002557_abnormal_social/conspecific_i	1.00716793
65	MP0005025_abnormal_response_to	0.99654564
66	MP0000230_abnormal_systemic_arterial	0.99439215
67	MP0000026_abnormal_inner_ear	0.97251535
68	MP0005387_immune_system_phenotype	0.96481222
69	MP0001790_abnormal_immune_system	0.96481222
70	MP0002822_catalepsy	0.95757729
71	MP0002090_abnormal_vision	0.95634278
72	MP0005171_absent_coat_pigmentation	0.95446261
73	MP0003172_abnormal_lysosome_physiology	0.95405019
74	MP0002693_abnormal_pancreas_physiology	0.92731708
75	MP0001486_abnormal_startle_reflex	0.91655813
76	MP0001963_abnormal_hearing_physiology	0.88902738
77	MP0003646_muscle_fatigue	0.88612689
78	MP0001853_heart_inflammation	0.86524419
79	MP0006054_spinal_hemorrhage	0.85260728
80	MP0003633_abnormal_nervous_system	0.84611099
81	MP0005423_abnormal_somatic_nervous	0.84263650
82	MP0002102_abnormal_ear_morphology	0.84071325
83	MP0005503_abnormal_tendon_morphology	0.83353992
84	MP0001986_abnormal_taste_sensitivity	0.82412656
85	MP0001845_abnormal_inflammatory_respons	0.82048902
86	MP0000639_abnormal_adrenal_gland	0.81327301
87	MP0002909_abnormal_adrenal_gland	0.81203447
88	MP0010030_abnormal_orbit_morphology	0.79896713
89	MP0002234_abnormal_pharynx_morphology	0.79302837
90	MP0002723_abnormal_immune_serum	0.78183212
91	MP0002282_abnormal_trachea_morphology	0.77954651
92	MP0005075_abnormal_melanosome_morpholog	0.74465567
93	MP0002734_abnormal_mechanical_nocicepti	0.74119284
94	MP0002067_abnormal_sensory_capabilities	0.71978805
95	MP0005332_abnormal_amino_acid	0.70585634
96	MP0001501_abnormal_sleep_pattern	0.70377294
97	MP0003195_calcinosis	0.69774201
98	MP0002063_abnormal_learning/memory/cond	0.69742049
99	MP0008872_abnormal_physiological_respon	0.69340170
100	MP0004145_abnormal_muscle_electrophysio	0.69248106

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	5.63869549
2	Mitochondrial inheritance (HP:0001427)	5.41609278
3	Abnormal mitochondria in muscle tissue (HP:0008316)	5.28346072
4	Progressive macrocephaly (HP:0004481)	4.91384629
5	Hepatocellular necrosis (HP:0001404)	4.65288560
6	Renal Fanconi syndrome (HP:0001994)	4.53941470
7	Acute encephalopathy (HP:0006846)	4.51786750
8	Increased CSF lactate (HP:0002490)	4.39512182
9	Hepatic necrosis (HP:0002605)	4.32208693
10	Increased hepatocellular lipid droplets (HP:0006565)	4.15426529
11	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.97973161
12	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.97973161
13	3-Methylglutaconic aciduria (HP:0003535)	3.90949807
14	Increased intramyocellular lipid droplets (HP:0012240)	3.79603898
15	Lipid accumulation in hepatocytes (HP:0006561)	3.69551336
16	Exertional dyspnea (HP:0002875)	3.33701153
17	Cerebral edema (HP:0002181)	3.24639344
18	Increased muscle lipid content (HP:0009058)	3.16779773
19	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.06107985
20	Respiratory failure (HP:0002878)	2.93121146
21	Abnormality of liposaccharide metabolism (HP:0010968)	2.90034191
22	Abnormality of glycosphingolipid metabolism (HP:0004343)	2.90034191
23	Abnormality of glycolipid metabolism (HP:0010969)	2.90034191
24	Myokymia (HP:0002411)	2.86974137
25	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.85564401
26	Abnormality of renal resorption (HP:0011038)	2.83934825
27	Abnormal number of erythroid precursors (HP:0012131)	2.80465261
28	Abnormality of cells of the erythroid lineage (HP:0012130)	2.79809981
29	True hermaphroditism (HP:0010459)	2.76840677
30	Abnormality of midbrain morphology (HP:0002418)	2.76704368
31	Molar tooth sign on MRI (HP:0002419)	2.76704368
32	Optic disc pallor (HP:0000543)	2.73961987
33	Congenital, generalized hypertrichosis (HP:0004540)	2.68125663
34	Generalized aminoaciduria (HP:0002909)	2.66761954
35	Polyphagia (HP:0002591)	2.66566159
36	Lactic acidosis (HP:0003128)	2.59681956
37	Pancreatic fibrosis (HP:0100732)	2.59468123
38	Vacuolated lymphocytes (HP:0001922)	2.58486568
39	Exercise intolerance (HP:0003546)	2.53404597
40	Medial flaring of the eyebrow (HP:0010747)	2.49258004
41	Prolonged neonatal jaundice (HP:0006579)	2.47543354
42	Petechiae (HP:0000967)	2.46666681
43	Pancreatic cysts (HP:0001737)	2.39501848
44	Methylmalonic aciduria (HP:0012120)	2.38174444
45	Reticulocytopenia (HP:0001896)	2.34864232
46	Abnormality of urine glucose concentration (HP:0011016)	2.33885605
47	Glycosuria (HP:0003076)	2.33885605
48	Agitation (HP:0000713)	2.25981487
49	Increased serum lactate (HP:0002151)	2.22829708
50	Leukodystrophy (HP:0002415)	2.22681224
51	Nephronophthisis (HP:0000090)	2.22279533
52	Sclerocornea (HP:0000647)	2.19626796
53	Dicarboxylic aciduria (HP:0003215)	2.15220944
54	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.15220944
55	Cutaneous melanoma (HP:0012056)	2.11103871
56	Dysostosis multiplex (HP:0000943)	2.08473395
57	Aplastic anemia (HP:0001915)	2.08031132
58	Lethargy (HP:0001254)	2.05830244
59	Septo-optic dysplasia (HP:0100842)	1.99667534
60	Methylmalonic acidemia (HP:0002912)	1.99046783
61	Focal dystonia (HP:0004373)	1.98631410
62	Severe visual impairment (HP:0001141)	1.98420354
63	Emotional lability (HP:0000712)	1.93957196
64	Type I transferrin isoform profile (HP:0003642)	1.92691758
65	Respiratory difficulties (HP:0002880)	1.91371056
66	Progressive neurologic deterioration (HP:0002344)	1.91081754
67	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.90867346
68	CNS demyelination (HP:0007305)	1.90519202
69	X-linked dominant inheritance (HP:0001423)	1.89086953
70	Macrocytic anemia (HP:0001972)	1.88445743
71	Hemiparesis (HP:0001269)	1.86509629
72	Purpura (HP:0000979)	1.84190224
73	Hyperphosphaturia (HP:0003109)	1.82553220
74	Abnormality of macrophages (HP:0004311)	1.81389776
75	Elevated erythrocyte sedimentation rate (HP:0003565)	1.80910934
76	Abnormal rod and cone electroretinograms (HP:0008323)	1.79862532
77	Craniofacial dystonia (HP:0012179)	1.78944668
78	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.78543029
79	Albinism (HP:0001022)	1.77843504
80	Congenital stationary night blindness (HP:0007642)	1.77265560
81	Gait imbalance (HP:0002141)	1.76087299
82	Congenital primary aphakia (HP:0007707)	1.75101861
83	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	1.74693598
84	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.74596516
85	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.74295636
86	Irregular vertebral endplates (HP:0003301)	1.70013363
87	Axonal loss (HP:0003447)	1.69253423
88	Nephrogenic diabetes insipidus (HP:0009806)	1.66896267
89	Hyperglycinemia (HP:0002154)	1.65455936
90	Increased IgM level (HP:0003496)	1.65136330
91	Hypoalbuminemia (HP:0003073)	1.64554420
92	Abnormal albumin level (HP:0012116)	1.64554420
93	Abnormal eating behavior (HP:0100738)	1.63425615
94	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.62526533
95	Decreased central vision (HP:0007663)	1.59695187
96	Blindness (HP:0000618)	1.59618412
97	Abnormal respiratory motile cilium morphology (HP:0005938)	1.59401662
98	Abnormal respiratory epithelium morphology (HP:0012253)	1.59401662
99	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.58195006
100	Progressive microcephaly (HP:0000253)	1.55947915

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	3.73124754
2	BCKDK	3.22589923
3	LIMK1	2.88433313
4	STK16	2.83707236
5	TESK2	2.44966592
6	TESK1	2.36818789
7	EPHB2	2.31938425
8	MAP3K12	2.22016912
9	ADRBK2	2.20262783
10	MAP4K2	2.16684537
11	FRK	2.00418612
12	VRK1	1.99976610
13	MYLK	1.97831732
14	NME2	1.92570249
15	PIM2	1.89771339
16	MAP3K11	1.87091862
17	TXK	1.74876465
18	ZAK	1.73095542
19	GRK7	1.68801480
20	KDR	1.63099278
21	TLK1	1.61708026
22	GRK1	1.59131358
23	CDK19	1.54478393
24	DYRK2	1.54417082
25	MAP2K7	1.54053636
26	NUAK1	1.52689332
27	ABL2	1.46024588
28	PINK1	1.41939817
29	CSNK1G3	1.37255619
30	ARAF	1.36837697
31	DAPK3	1.35244605
32	CAMKK2	1.32036804
33	CSNK1G2	1.23358499
34	PRKD3	1.17250042
35	MST4	1.17176132
36	MAPK15	1.16942072
37	GRK5	1.16324284
38	IKBKB	1.12487425
39	BMPR1B	1.10163512
40	ADRBK1	1.07540321
41	CSNK1G1	1.03074925
42	TAOK3	0.94871834
43	CSNK1A1L	0.93995560
44	TBK1	0.89675061
45	ILK	0.88291998
46	WNK3	0.87845817
47	PRKCG	0.87255385
48	TAOK2	0.85535946
49	PAK3	0.83794823
50	EPHA4	0.82530312
51	MAPKAPK3	0.80611450
52	DAPK2	0.78909776
53	LRRK2	0.76121392
54	PRKCQ	0.74808659
55	IKBKE	0.73249215
56	INSRR	0.72006099
57	MUSK	0.68116641
58	DAPK1	0.67038333
59	SYK	0.66663853
60	LMTK2	0.66087129
61	PRKCE	0.65845785
62	KIT	0.63335469
63	PAK1	0.63258078
64	PHKG1	0.62941081
65	PHKG2	0.62941081
66	TNK2	0.62870038
67	PTK2B	0.59423393
68	ROCK1	0.58981362
69	PLK2	0.58904935
70	MAP3K4	0.58683922
71	NTRK2	0.57711074
72	MAP2K6	0.57676610
73	PKN1	0.55974856
74	MAPK13	0.55966013
75	RPS6KA5	0.55832408
76	CAMK2D	0.54187503
77	DDR2	0.53231896
78	PNCK	0.50717472
79	ITK	0.49878610
80	CAMK2G	0.49807161
81	FES	0.49153020
82	FGFR2	0.48181119
83	TAF1	0.47716738
84	PRKCD	0.46691499
85	LYN	0.46655359
86	PRKACA	0.44508673
87	CSNK1A1	0.44308205
88	PRKCA	0.43775241
89	MINK1	0.43684978
90	AURKA	0.43656912
91	PIK3CG	0.43248630
92	CAMK1	0.42469973
93	CAMK2A	0.42188963
94	MAPKAPK5	0.40620499
95	MARK1	0.35213958
96	TIE1	0.34569585
97	TEC	0.33758633
98	WNK4	0.33061554
99	CASK	0.32362597
100	TGFBR2	0.31291634

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	5.69261849
2	Parkinsons disease_Homo sapiens_hsa05012	4.55827411
3	Ribosome_Homo sapiens_hsa03010	3.72231248
4	Proteasome_Homo sapiens_hsa03050	3.22520338
5	Alzheimers disease_Homo sapiens_hsa05010	3.21340767
6	Huntingtons disease_Homo sapiens_hsa05016	2.99642357
7	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.90630257
8	Protein export_Homo sapiens_hsa03060	2.68527185
9	Cardiac muscle contraction_Homo sapiens_hsa04260	2.60587263
10	Collecting duct acid secretion_Homo sapiens_hsa04966	2.06904855
11	Rheumatoid arthritis_Homo sapiens_hsa05323	1.91419804
12	Sulfur metabolism_Homo sapiens_hsa00920	1.83516016
13	RNA polymerase_Homo sapiens_hsa03020	1.75886892
14	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.69422049
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.60938203
16	Type I diabetes mellitus_Homo sapiens_hsa04940	1.55496270
17	Graft-versus-host disease_Homo sapiens_hsa05332	1.54652146
18	Folate biosynthesis_Homo sapiens_hsa00790	1.50052256
19	Asthma_Homo sapiens_hsa05310	1.49543974
20	Allograft rejection_Homo sapiens_hsa05330	1.48246823
21	Primary immunodeficiency_Homo sapiens_hsa05340	1.46318611
22	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.42404702
23	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.41799149
24	Glutathione metabolism_Homo sapiens_hsa00480	1.38544776
25	Fatty acid elongation_Homo sapiens_hsa00062	1.33051513
26	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.29656189
27	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.19981196
28	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.14606421
29	Peroxisome_Homo sapiens_hsa04146	1.11781309
30	Antigen processing and presentation_Homo sapiens_hsa04612	1.11669300
31	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.11261089
32	Lysosome_Homo sapiens_hsa04142	1.08348622
33	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.08288758
34	Phototransduction_Homo sapiens_hsa04744	1.04703177
35	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.01552924
36	Vibrio cholerae infection_Homo sapiens_hsa05110	1.00052843
37	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.99583210
38	Sulfur relay system_Homo sapiens_hsa04122	0.98579278
39	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.90108267
40	Pyrimidine metabolism_Homo sapiens_hsa00240	0.89079032
41	Butanoate metabolism_Homo sapiens_hsa00650	0.85904896
42	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.84556500
43	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.82304654
44	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.80194113
45	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.79127686
46	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.78576175
47	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.77300062
48	Phagosome_Homo sapiens_hsa04145	0.75832571
49	Salmonella infection_Homo sapiens_hsa05132	0.73704441
50	Metabolic pathways_Homo sapiens_hsa01100	0.70473359
51	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.67197036
52	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.64979652
53	Nicotine addiction_Homo sapiens_hsa05033	0.64101219
54	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.63680750
55	Tryptophan metabolism_Homo sapiens_hsa00380	0.62663279
56	Purine metabolism_Homo sapiens_hsa00230	0.62284204
57	Mineral absorption_Homo sapiens_hsa04978	0.61304489
58	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.61116143
59	Chemical carcinogenesis_Homo sapiens_hsa05204	0.60528106
60	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.60097425
61	Linoleic acid metabolism_Homo sapiens_hsa00591	0.59623654
62	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.59124733
63	Other glycan degradation_Homo sapiens_hsa00511	0.58255560
64	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.55799739
65	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.55630501
66	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.53556803
67	Regulation of autophagy_Homo sapiens_hsa04140	0.50963531
68	GABAergic synapse_Homo sapiens_hsa04727	0.50454584
69	Nitrogen metabolism_Homo sapiens_hsa00910	0.49351292
70	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.46369809
71	Homologous recombination_Homo sapiens_hsa03440	0.46121376
72	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.45453115
73	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.44766058
74	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.44101838
75	Ether lipid metabolism_Homo sapiens_hsa00565	0.42292305
76	Morphine addiction_Homo sapiens_hsa05032	0.41799856
77	Malaria_Homo sapiens_hsa05144	0.41721478
78	Pertussis_Homo sapiens_hsa05133	0.40248176
79	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.35556163
80	Salivary secretion_Homo sapiens_hsa04970	0.34340991
81	Steroid biosynthesis_Homo sapiens_hsa00100	0.33653851
82	Insulin secretion_Homo sapiens_hsa04911	0.33153968
83	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.32499077
84	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.31618707
85	Alcoholism_Homo sapiens_hsa05034	0.31417877
86	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.30575959
87	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.30110595
88	Shigellosis_Homo sapiens_hsa05131	0.29605029
89	Olfactory transduction_Homo sapiens_hsa04740	0.27918979
90	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.27733875
91	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.27129507
92	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.24778086
93	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.24774309
94	Viral myocarditis_Homo sapiens_hsa05416	0.23201960
95	Serotonergic synapse_Homo sapiens_hsa04726	0.22558781
96	Circadian entrainment_Homo sapiens_hsa04713	0.21813501
97	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.19818687
98	Galactose metabolism_Homo sapiens_hsa00052	0.19729203
99	Cocaine addiction_Homo sapiens_hsa05030	0.19082136
100	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.18048961

IFI27L2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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