IFI30

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a lysosomal thiol reductase that at low pH can reduce protein disulfide bonds. The enzyme is expressed constitutively in antigen-presenting cells and induced by gamma-interferon in other cell types. This enzyme has an important role in MHC class II-restricted antigen processing. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous antigen (GO:0019883)5.78575961
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.55402181
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.55402181
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.49750377
5glycosphingolipid catabolic process (GO:0046479)4.49575289
6NIK/NF-kappaB signaling (GO:0038061)4.41435852
7immunoglobulin mediated immune response (GO:0016064)4.35848125
8regulation of interferon-beta biosynthetic process (GO:0045357)4.32143405
9neutrophil activation involved in immune response (GO:0002283)4.29662762
10cellular response to thyroid hormone stimulus (GO:0097067)4.17417002
11negative regulation of cell killing (GO:0031342)4.16088454
12negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.16088454
13regulation of B cell receptor signaling pathway (GO:0050855)4.16079049
14oligosaccharide catabolic process (GO:0009313)4.16066870
15detection of other organism (GO:0098543)4.13190056
16amino sugar catabolic process (GO:0046348)4.08849123
17regulation of mononuclear cell migration (GO:0071675)4.05292803
18positive regulation of mast cell activation (GO:0033005)4.05046890
19glycolipid catabolic process (GO:0019377)4.04430823
20regulation of dendritic cell antigen processing and presentation (GO:0002604)4.04094726
21detection of molecule of bacterial origin (GO:0032490)3.96736931
22positive regulation of antigen processing and presentation (GO:0002579)3.96304564
23positive regulation of interferon-alpha production (GO:0032727)3.93972804
24positive regulation by symbiont of host defense response (GO:0052509)3.88995083
25modulation by symbiont of host defense response (GO:0052031)3.88995083
26modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.88995083
27modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.88995083
28positive regulation by organism of defense response of other organism involved in symbiotic interact3.88995083
29modulation by symbiont of host immune response (GO:0052553)3.88995083
30detection of bacterium (GO:0016045)3.84764660
31T-helper 1 type immune response (GO:0042088)3.78160187
32detection of external biotic stimulus (GO:0098581)3.77711726
33B cell receptor signaling pathway (GO:0050853)3.75315968
34regulation of interferon-alpha production (GO:0032647)3.70113587
35regulation of mast cell activation involved in immune response (GO:0033006)3.68186753
36ceramide catabolic process (GO:0046514)3.58613763
37positive regulation of gamma-delta T cell activation (GO:0046645)3.57218889
38natural killer cell mediated cytotoxicity (GO:0042267)3.55972111
39natural killer cell mediated immunity (GO:0002228)3.55972111
40Arp2/3 complex-mediated actin nucleation (GO:0034314)3.55625748
41regulation of leukocyte degranulation (GO:0043300)3.51624584
42regulation of antigen processing and presentation (GO:0002577)3.50941709
43positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.50610957
44positive regulation of monocyte chemotaxis (GO:0090026)3.50357243
45positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.49908006
46N-acetylneuraminate metabolic process (GO:0006054)3.48986991
47regulation of mast cell activation (GO:0033003)3.48849296
48macrophage activation involved in immune response (GO:0002281)3.48806440
49neutrophil activation (GO:0042119)3.47258987
50cellular response to zinc ion (GO:0071294)3.46810480
51B cell mediated immunity (GO:0019724)3.46156476
52regulation of myeloid leukocyte mediated immunity (GO:0002886)3.45156123
53respiratory burst (GO:0045730)3.41780915
54macrophage activation (GO:0042116)3.39648368
55regulation of B cell differentiation (GO:0045577)3.34534839
56granulocyte activation (GO:0036230)3.34078460
57regulation of macrophage chemotaxis (GO:0010758)3.33799314
58detection of biotic stimulus (GO:0009595)3.33617844
59response to thyroid hormone (GO:0097066)3.29952898
60positive regulation of B cell differentiation (GO:0045579)3.28659883
61regulation of interleukin-12 biosynthetic process (GO:0045075)3.27504037
62positive regulation of cellular amide metabolic process (GO:0034250)3.25281364
63response to peptidoglycan (GO:0032494)3.20523715
64microglial cell activation (GO:0001774)3.16976995
65myeloid dendritic cell differentiation (GO:0043011)3.13107012
66myeloid dendritic cell activation (GO:0001773)3.07565584
67regulation of T cell tolerance induction (GO:0002664)3.07004979
68regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.04558921
69hepatocyte apoptotic process (GO:0097284)3.02407059
70negative regulation of cytokine production involved in immune response (GO:0002719)2.97080306
71negative regulation of erythrocyte differentiation (GO:0045647)2.95726214
72response to muramyl dipeptide (GO:0032495)2.93938669
73negative regulation of B cell proliferation (GO:0030889)2.93650970
74positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.93252075
75membrane lipid catabolic process (GO:0046466)2.93010344
76positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.92655977
77regulation of monocyte chemotaxis (GO:0090025)2.90968659
78positive regulation of interferon-beta production (GO:0032728)2.89497773
79phagosome maturation (GO:0090382)2.89477740
80response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.89441930
81response to host immune response (GO:0052572)2.89441930
82negative regulation of myeloid cell apoptotic process (GO:0033033)2.88133457
83regulation of tolerance induction (GO:0002643)2.87609279
84* interferon-gamma-mediated signaling pathway (GO:0060333)2.85012716
85positive regulation of type 2 immune response (GO:0002830)2.84167990
86JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.83819716
87leukocyte mediated cytotoxicity (GO:0001909)2.83118752
88regulation of cholesterol storage (GO:0010885)2.83012475
89sphingolipid catabolic process (GO:0030149)2.82976297
90dendritic cell differentiation (GO:0097028)2.82781166
91hydrogen peroxide biosynthetic process (GO:0050665)2.82713299
92regulation of podosome assembly (GO:0071801)2.79435146
93regulation of regulated secretory pathway (GO:1903305)2.79034518
94negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.78576897
95mature B cell differentiation (GO:0002335)2.78564917
96regulation of hypersensitivity (GO:0002883)2.77634878
97pinocytosis (GO:0006907)2.77629793
98* cellular response to interferon-gamma (GO:0071346)2.77522517
99germinal center formation (GO:0002467)2.77036201
100monocyte chemotaxis (GO:0002548)2.76950881
101response to protozoan (GO:0001562)2.76713653
102regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.76527486
103lymphocyte mediated immunity (GO:0002449)2.74283092
104lipopolysaccharide-mediated signaling pathway (GO:0031663)2.73982932
105response to type I interferon (GO:0034340)2.72612856
106positive regulation of protein oligomerization (GO:0032461)2.71328142
107cellular response to type I interferon (GO:0071357)2.70416169
108type I interferon signaling pathway (GO:0060337)2.70416169
109positive regulation of interleukin-12 production (GO:0032735)2.66128782
110actin nucleation (GO:0045010)2.63618577
111regulation of RIG-I signaling pathway (GO:0039535)2.63033522
112cellular response to interferon-beta (GO:0035458)2.62800343
113positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.62782996
114negative regulation of interleukin-12 production (GO:0032695)2.62001406
115regulation of B cell apoptotic process (GO:0002902)2.61636191
116regulation of gamma-delta T cell differentiation (GO:0045586)2.60035402
117interferon-gamma secretion (GO:0072643)2.59825133
118negative regulation of phagocytosis (GO:0050765)2.59442805
119regulation of interleukin-12 production (GO:0032655)2.56808822
120regulation of mast cell degranulation (GO:0043304)2.55269644
121regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.53472336
122negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.53452508
123regulation of gamma-delta T cell activation (GO:0046643)2.53045095
124defense response to protozoan (GO:0042832)2.52393968
125regulation of superoxide anion generation (GO:0032928)2.51699151
126positive thymic T cell selection (GO:0045059)2.49133849
127regulation of B cell proliferation (GO:0030888)2.47334097
128viral transcription (GO:0019083)2.47232531
129ribosomal small subunit assembly (GO:0000028)2.45524087
130regulation of type I interferon-mediated signaling pathway (GO:0060338)2.44931560
131positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.43257321
132regulation of interferon-beta production (GO:0032648)2.42412640
133myeloid cell activation involved in immune response (GO:0002275)2.42387440
134T cell migration (GO:0072678)2.42026791
135negative regulation of granulocyte differentiation (GO:0030853)2.41877718
136cellular response to exogenous dsRNA (GO:0071360)2.41675609
137cellular extravasation (GO:0045123)2.41416794
138cytokine secretion (GO:0050663)2.41212451
139regulation of alpha-beta T cell proliferation (GO:0046640)2.39773864
140adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.39629932
141dendritic cell migration (GO:0036336)2.37913581
142positive regulation of cytokine biosynthetic process (GO:0042108)2.37133526
143positive regulation of neutrophil migration (GO:1902624)2.36742176
144positive regulation of neutrophil chemotaxis (GO:0090023)2.36742176
145T cell apoptotic process (GO:0070231)2.36529120
146positive regulation of granulocyte chemotaxis (GO:0071624)2.35854652
147mature B cell differentiation involved in immune response (GO:0002313)2.35189841
148positive regulation of mast cell activation involved in immune response (GO:0033008)2.35140514
149positive regulation of mast cell degranulation (GO:0043306)2.35140514
150dendritic cell chemotaxis (GO:0002407)2.34861489
151positive regulation of leukocyte degranulation (GO:0043302)2.34515051
152antigen processing and presentation via MHC class Ib (GO:0002475)2.33367689

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.30742647
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.30372102
3E2F7_22180533_ChIP-Seq_HELA_Human3.24239880
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.23038885
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.17531389
6IRF8_27001747_Chip-Seq_BMDM_Mouse2.93651576
7* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.76777874
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.59828375
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.50883515
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.50725918
11MYC_22102868_ChIP-Seq_BL_Human2.49660132
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.45195663
13VDR_21846776_ChIP-Seq_THP-1_Human2.34699837
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.32870244
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.26379031
16* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.22548184
17VDR_24787735_ChIP-Seq_THP-1_Human2.18193248
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.12993576
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.09828555
20* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.08289354
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.98529846
22SPI1_23547873_ChIP-Seq_NB4_Human1.96895223
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.96548938
24EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.95865533
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.94349821
26STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.93878286
27BRD4_27068464_Chip-Seq_AML-cells_Mouse1.92944427
28MAF_26560356_Chip-Seq_TH1_Human1.90276775
29STAT4_19710469_ChIP-ChIP_TH1__Mouse1.86456142
30VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.84156647
31BP1_19119308_ChIP-ChIP_Hs578T_Human1.78206218
32VDR_24763502_ChIP-Seq_THP-1_Human1.73992382
33STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.73545465
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.73276080
35MYB_26560356_Chip-Seq_TH2_Human1.72233781
36FOXM1_23109430_ChIP-Seq_U2OS_Human1.71572550
37E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.70766758
38LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.60694478
39MYB_26560356_Chip-Seq_TH1_Human1.55511377
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.51114869
41FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.49987146
42RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.49056244
43Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.46880702
44ELK3_25401928_ChIP-Seq_HUVEC_Human1.46832532
45UTX_26944678_Chip-Seq_JUKART_Human1.44337598
46TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.40278991
47TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40147812
48STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.39174586
49* TCF7_22412390_ChIP-Seq_EML_Mouse1.34812666
50GATA1_19941827_ChIP-Seq_MEL_Mouse1.33097380
51SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.32848106
52STAT6_21828071_ChIP-Seq_BEAS2B_Human1.30831422
53SPI1_23127762_ChIP-Seq_K562_Human1.29490182
54NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.25763871
55FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.25646223
56GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.24808214
57FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.23915731
58GATA1_22025678_ChIP-Seq_K562_Human1.23896466
59TFEB_21752829_ChIP-Seq_HELA_Human1.23696096
60MAF_26560356_Chip-Seq_TH2_Human1.22647128
61PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21106682
62CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21064144
63* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19084553
64PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18815269
65* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18499230
66STAT3_1855785_ChIP-Seq_MESCs_Mouse1.16506164
67GATA2_22383799_ChIP-Seq_G1ME_Mouse1.15788519
68KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12722452
69PU_27001747_Chip-Seq_BMDM_Mouse1.12684430
70GATA1_19941826_ChIP-Seq_K562_Human1.10904615
71RUNX_20019798_ChIP-Seq_JUKART_Human1.10706240
72STAT1_20625510_ChIP-Seq_HELA_Human1.08246528
73MYC_18555785_ChIP-Seq_MESCs_Mouse1.08106307
74THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.06523404
75IKZF1_21737484_ChIP-ChIP_HCT116_Human1.05834316
76SCL_19346495_ChIP-Seq_HPC-7_Human1.05681311
77* BCL6_27268052_Chip-Seq_Bcells_Human1.05195823
78TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.04875434
79KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.04485646
80MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.04227780
81KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.03148997
82ELF1_17652178_ChIP-ChIP_JURKAT_Human1.02826567
83KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02682142
84* KDM2B_26808549_Chip-Seq_DND41_Human1.02179255
85* BCOR_27268052_Chip-Seq_Bcells_Human1.01903072
86FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.01764445
87E2F4_17652178_ChIP-ChIP_JURKAT_Human1.00853650
88CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.99887270
89TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.99373603
90PPARA_22158963_ChIP-Seq_LIVER_Mouse0.98866590
91SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98679378
92* LXR_22292898_ChIP-Seq_THP-1_Human0.98293125
93ERG_20887958_ChIP-Seq_HPC-7_Mouse0.96966283
94GATA3_27048872_Chip-Seq_THYMUS_Human0.96644216
95TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.96577801
96SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.95085683
97KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95008247
98CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94390939
99RARG_19884340_ChIP-ChIP_MEFs_Mouse0.94221603
100GATA3_26560356_Chip-Seq_TH2_Human0.93894756
101SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93840450
102GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92627736
103PU.1_20513432_ChIP-Seq_Bcells_Mouse0.92401970
104TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92055076
105MYC_19079543_ChIP-ChIP_MESCs_Mouse0.91486533
106GATA2_21666600_ChIP-Seq_HMVEC_Human0.91412065
107NCOR1_26117541_ChIP-Seq_K562_Human0.91231204
108ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.90982388
109HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.90823452
110LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.90742636
111CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90739744
112PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90456988
113PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.90008824
114CLOCK_20551151_ChIP-Seq_293T_Human0.89753119
115SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.89258627
116* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.89205598
117ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.88351235
118PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87915233
119ELF1_20517297_ChIP-Seq_JURKAT_Human0.87632850
120RACK7_27058665_Chip-Seq_MCF-7_Human0.87407721
121FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.86807233
122VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.85802145
123RXR_22158963_ChIP-Seq_LIVER_Mouse0.84439291
124SRY_22984422_ChIP-ChIP_TESTIS_Rat0.80367282

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.43229525
2MP0005387_immune_system_phenotype3.03447422
3MP0001790_abnormal_immune_system3.03447422
4MP0000685_abnormal_immune_system3.02211929
5MP0001800_abnormal_humoral_immune2.90860559
6MP0003436_decreased_susceptibility_to2.86086173
7MP0003303_peritoneal_inflammation2.84184609
8* MP0002452_abnormal_antigen_presenting2.66052986
9MP0005000_abnormal_immune_tolerance2.61064510
10MP0002148_abnormal_hypersensitivity_rea2.50762789
11MP0002138_abnormal_hepatobiliary_system2.33926924
12MP0002723_abnormal_immune_serum2.28812895
13MP0002419_abnormal_innate_immunity2.27798081
14MP0004510_myositis2.26052779
15MP0005025_abnormal_response_to2.22352613
16MP0005671_abnormal_response_to2.20088791
17MP0009785_altered_susceptibility_to2.18317770
18MP0002420_abnormal_adaptive_immunity2.17321027
19MP0001819_abnormal_immune_cell2.17282992
20MP0005058_abnormal_lysosome_morphology2.16235989
21MP0002166_altered_tumor_susceptibility2.07582724
22MP0002139_abnormal_hepatobiliary_system2.07286725
23MP0002254_reproductive_system_inflammat2.03561575
24MP0010352_gastrointestinal_tract_polyps2.01976924
25MP0003806_abnormal_nucleotide_metabolis1.93887887
26MP0004947_skin_inflammation1.88677564
27MP0001873_stomach_inflammation1.87889964
28MP0002405_respiratory_system_inflammati1.85749556
29MP0001853_heart_inflammation1.84188871
30MP0003300_gastrointestinal_ulcer1.81873981
31MP0005310_abnormal_salivary_gland1.79150542
32MP0000716_abnormal_immune_system1.74883670
33MP0002398_abnormal_bone_marrow1.74877335
34MP0003690_abnormal_glial_cell1.73884804
35MP0009333_abnormal_splenocyte_physiolog1.68475131
36MP0010155_abnormal_intestine_physiology1.67995488
37MP0006082_CNS_inflammation1.67606934
38MP0002006_tumorigenesis1.67452064
39MP0001845_abnormal_inflammatory_respons1.67030817
40MP0009840_abnormal_foam_cell1.66512854
41MP0000689_abnormal_spleen_morphology1.58944182
42MP0005451_abnormal_body_composition1.57949861
43MP0003705_abnormal_hypodermis_morpholog1.54808215
44MP0002429_abnormal_blood_cell1.49549186
45MP0002722_abnormal_immune_system1.44678054
46MP0008260_abnormal_autophagy1.44676429
47MP0003566_abnormal_cell_adhesion1.43488734
48MP0005464_abnormal_platelet_physiology1.42253260
49MP0005076_abnormal_cell_differentiation1.42175355
50MP0003191_abnormal_cellular_cholesterol1.40960151
51MP0001533_abnormal_skeleton_physiology1.39388736
52MP0010234_abnormal_vibrissa_follicle1.37612439
53MP0005166_decreased_susceptibility_to1.29083533
54MP0008469_abnormal_protein_level1.27924379
55MP0003448_altered_tumor_morphology1.27669521
56MP0003172_abnormal_lysosome_physiology1.25028847
57MP0003453_abnormal_keratinocyte_physiol1.24901645
58MP0000490_abnormal_crypts_of1.23867048
59MP0006054_spinal_hemorrhage1.22431259
60MP0005167_abnormal_blood-brain_barrier1.21363306
61MP0003329_amyloid_beta_deposits1.19980503
62MP0000858_altered_metastatic_potential1.17295526
63MP0002877_abnormal_melanocyte_morpholog1.15911553
64MP0002396_abnormal_hematopoietic_system1.12333619
65MP0003763_abnormal_thymus_physiology1.10585847
66MP0010307_abnormal_tumor_latency1.08832997
67MP0000920_abnormal_myelination1.07836998
68MP0002933_joint_inflammation1.02730025
69MP0003724_increased_susceptibility_to1.02607793
70MP0003693_abnormal_embryo_hatching1.02212950
71MP0003183_abnormal_peptide_metabolism1.01860064
72MP0005365_abnormal_bile_salt1.01012828
73MP0003866_abnormal_defecation0.99933067
74MP0002136_abnormal_kidney_physiology0.99744821
75MP0004883_abnormal_blood_vessel0.96511992
76MP0002998_abnormal_bone_remodeling0.95518353
77MP0003656_abnormal_erythrocyte_physiolo0.95266800
78MP0009764_decreased_sensitivity_to0.94652978
79MP0005164_abnormal_response_to0.93610276
80MP0005397_hematopoietic_system_phenotyp0.92958664
81MP0001545_abnormal_hematopoietic_system0.92958664
82MP0002277_abnormal_respiratory_mucosa0.92925805
83MP0008004_abnormal_stomach_pH0.92833991
84MP0000343_altered_response_to0.89306168
85MP0005023_abnormal_wound_healing0.89283773
86MP0009763_increased_sensitivity_to0.88087399
87MP0000703_abnormal_thymus_morphology0.87273193
88MP0000465_gastrointestinal_hemorrhage0.84782929
89MP0002019_abnormal_tumor_incidence0.83087535
90MP0004782_abnormal_surfactant_physiolog0.82872813
91MP0008438_abnormal_cutaneous_collagen0.82453151
92MP0003091_abnormal_cell_migration0.82362528
93MP0009278_abnormal_bone_marrow0.81801177
94MP0009643_abnormal_urine_homeostasis0.80145176
95MP0001958_emphysema0.79450490
96MP0003795_abnormal_bone_structure0.79241444
97MP0001348_abnormal_lacrimal_gland0.76589609
98MP0004808_abnormal_hematopoietic_stem0.75296733
99MP0001851_eye_inflammation0.75210582
100MP0002009_preneoplasia0.73413218
101MP0001216_abnormal_epidermal_layer0.73407404
102MP0001663_abnormal_digestive_system0.72896587
103MP0000604_amyloidosis0.72547864
104MP0003077_abnormal_cell_cycle0.70941783
105MP0000371_diluted_coat_color0.70576665
106MP0000609_abnormal_liver_physiology0.70535939
107MP0000249_abnormal_blood_vessel0.69843897
108MP0005165_increased_susceptibility_to0.69609528
109MP0005257_abnormal_intraocular_pressure0.69118493
110MP0004957_abnormal_blastocyst_morpholog0.68999595
111MP0003075_altered_response_to0.68070805
112MP0005390_skeleton_phenotype0.67735278
113MP0008057_abnormal_DNA_replication0.66857087
114MP0003828_pulmonary_edema0.65698516
115MP0005319_abnormal_enzyme/_coenzyme0.65361833
116MP0005174_abnormal_tail_pigmentation0.65318914
117MP0002796_impaired_skin_barrier0.65198448
118MP0002090_abnormal_vision0.65195624
119MP0000767_abnormal_smooth_muscle0.65111857
120MP0003186_abnormal_redox_activity0.64787213
121MP0004264_abnormal_extraembryonic_tissu0.64493073
122MP0005584_abnormal_enzyme/coenzyme_acti0.61115724
123MP0008874_decreased_physiological_sensi0.60977434
124MP0009765_abnormal_xenobiotic_induced0.58429299
125MP0004019_abnormal_vitamin_homeostasis0.57422622
126MP0001542_abnormal_bone_strength0.56934519
127MP0003634_abnormal_glial_cell0.56468943
128MP0000015_abnormal_ear_pigmentation0.53265359
129MP0002132_abnormal_respiratory_system0.52461802
130MP0005647_abnormal_sex_gland0.51432134

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.27649001
2Recurrent bacterial skin infections (HP:0005406)4.99132095
3Eczematoid dermatitis (HP:0000976)4.66215414
4Disinhibition (HP:0000734)4.61006665
5Agammaglobulinemia (HP:0004432)4.20971832
6Cellulitis (HP:0100658)4.02652728
7Colitis (HP:0002583)3.92377945
8Recurrent viral infections (HP:0004429)3.79606962
9Gastrointestinal stroma tumor (HP:0100723)3.74185330
10Interstitial pulmonary disease (HP:0006530)3.68625122
11Vacuolated lymphocytes (HP:0001922)3.67657627
12Recurrent gram-negative bacterial infections (HP:0005420)3.65609834
13Mutism (HP:0002300)3.64925558
14Recurrent fungal infections (HP:0002841)3.60929021
15Abnormality of macrophages (HP:0004311)3.54116776
16Recurrent bronchitis (HP:0002837)3.51795976
17Systemic lupus erythematosus (HP:0002725)3.48528173
18Pustule (HP:0200039)3.48094933
19Inflammation of the large intestine (HP:0002037)3.44969884
20Recurrent skin infections (HP:0001581)3.33376299
21Gastrointestinal inflammation (HP:0004386)3.31872345
22Elevated erythrocyte sedimentation rate (HP:0003565)3.29916912
23Autoimmune thrombocytopenia (HP:0001973)3.26173282
24IgM deficiency (HP:0002850)3.24533566
25Mediastinal lymphadenopathy (HP:0100721)3.22520956
26Stomatitis (HP:0010280)3.20218347
27Neurofibrillary tangles (HP:0002185)3.16954982
28Vasculitis (HP:0002633)3.14765227
29Emphysema (HP:0002097)3.05838069
30Hematochezia (HP:0002573)3.00372313
31Papilloma (HP:0012740)3.00268469
32Verrucae (HP:0200043)3.00268469
33Myositis (HP:0100614)2.99274379
34Dysostosis multiplex (HP:0000943)2.97961608
35Meningitis (HP:0001287)2.97597001
36Purpura (HP:0000979)2.95546683
37Increased cerebral lipofuscin (HP:0011813)2.89025785
38Chronic mucocutaneous candidiasis (HP:0002728)2.86099376
39Recurrent cutaneous fungal infections (HP:0011370)2.86099376
40Abnormality of the vasculature of the conjunctiva (HP:0008054)2.85190515
41Abnormal delayed hypersensitivity skin test (HP:0002963)2.85178169
42Recurrent pneumonia (HP:0006532)2.83404828
43Chronic otitis media (HP:0000389)2.83293406
44Agnosia (HP:0010524)2.82941483
45Osteomyelitis (HP:0002754)2.82612676
46Upper motor neuron abnormality (HP:0002127)2.77677457
47Gingivitis (HP:0000230)2.76250107
48Recurrent lower respiratory tract infections (HP:0002783)2.74727344
49Lymphopenia (HP:0001888)2.74580932
50Increased IgE level (HP:0003212)2.74517962
51Abnormality of cells of the lymphoid lineage (HP:0012140)2.73939499
52Thrombocytosis (HP:0001894)2.70290872
53Periodontitis (HP:0000704)2.68922071
54Increased serum ferritin (HP:0003281)2.64589483
55Apathy (HP:0000741)2.63742116
56Diminished motivation (HP:0000745)2.63662880
57Neuronal loss in central nervous system (HP:0002529)2.63456283
58Nuclear cataract (HP:0100018)2.61494354
59Chronic obstructive pulmonary disease (HP:0006510)2.60521461
60Obstructive lung disease (HP:0006536)2.60521461
61Amyloidosis (HP:0011034)2.58901552
62Inappropriate behavior (HP:0000719)2.58570156
63Myocardial infarction (HP:0001658)2.57762232
64Hepatosplenomegaly (HP:0001433)2.57143305
65Mucopolysacchariduria (HP:0008155)2.54975366
66Urinary glycosaminoglycan excretion (HP:0003541)2.54975366
67Osteolytic defects of the hand bones (HP:0009699)2.53951627
68Osteolytic defects of the phalanges of the hand (HP:0009771)2.53951627
69Abnormality of glycolipid metabolism (HP:0010969)2.52642780
70Abnormality of liposaccharide metabolism (HP:0010968)2.52642780
71Abnormality of glycosphingolipid metabolism (HP:0004343)2.52642780
72Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.51933317
73Progressive neurologic deterioration (HP:0002344)2.50015914
74Restrictive lung disease (HP:0002091)2.49834839
75Increased neuronal autofluorescent lipopigment (HP:0002074)2.49605036
76Orchitis (HP:0100796)2.45361461
77Abnormality of T cell physiology (HP:0011840)2.43961096
78Petechiae (HP:0000967)2.43608057
79Recurrent sinusitis (HP:0011108)2.38450592
80Nasal polyposis (HP:0100582)2.36692042
81Spontaneous hematomas (HP:0007420)2.34228340
82Hemoptysis (HP:0002105)2.33242457
83Urticaria (HP:0001025)2.30198453
84Personality changes (HP:0000751)2.29501986
85Abnormality of mucopolysaccharide metabolism (HP:0011020)2.27539995
86Abnormality of polysaccharide metabolism (HP:0011012)2.27539995
87Abnormality of glycosaminoglycan metabolism (HP:0004371)2.27539995
88Skin ulcer (HP:0200042)2.25693017
89Glomerulonephritis (HP:0000099)2.25421456
90Cerebral inclusion bodies (HP:0100314)2.24725872
91Fatigue (HP:0012378)2.22420904
92Abnormality of the nasal mucosa (HP:0000433)2.21448547
93Sepsis (HP:0100806)2.20647671
94Complement deficiency (HP:0004431)2.19787036
95Retinal atrophy (HP:0001105)2.17070136
96Abnormality of iron homeostasis (HP:0011031)2.15824876
97Panhypogammaglobulinemia (HP:0003139)2.15285638
98Keratoconjunctivitis sicca (HP:0001097)2.14557321
99Chronic sinusitis (HP:0011109)2.14021326
100Peritonitis (HP:0002586)2.13423229
101T lymphocytopenia (HP:0005403)2.13366102
102Pulmonary infiltrates (HP:0002113)2.12991321
103Poor head control (HP:0002421)2.12960235
104Arterial thrombosis (HP:0004420)2.12915169
105Polyneuropathy (HP:0001271)2.11600760
106Pathologic fracture (HP:0002756)2.11110021
107Malnutrition (HP:0004395)2.10330921
108IgA deficiency (HP:0002720)2.09864965
109Dementia (HP:0000726)2.06995451
110Abnormality of T cells (HP:0002843)2.06331545
111Gastrointestinal infarctions (HP:0005244)2.01968531
112Metaphyseal irregularity (HP:0003025)2.01130465
113Vertebral compression fractures (HP:0002953)1.99844173
114Encephalitis (HP:0002383)1.99335285
115Global brain atrophy (HP:0002283)1.98670706
116Bronchitis (HP:0012387)1.97648964
117Hypergammaglobulinemia (HP:0010702)1.96814969
118Abnormality of the periventricular white matter (HP:0002518)1.96499354
119Prolonged neonatal jaundice (HP:0006579)1.94890290
120Leukopenia (HP:0001882)1.94799627
121Keratoconjunctivitis (HP:0001096)1.94439987
122Peripheral demyelination (HP:0011096)1.94297011
123Increased IgM level (HP:0003496)1.94111268
124Abnormality of T cell number (HP:0011839)1.93923767
125Axonal loss (HP:0003447)1.93769993
126Basal ganglia calcification (HP:0002135)1.93418372
127Premature loss of primary teeth (HP:0006323)1.92308374
128Retrobulbar optic neuritis (HP:0100654)1.90639633
129Optic neuritis (HP:0100653)1.90639633
130Leukocytosis (HP:0001974)1.89035671
131Memory impairment (HP:0002354)1.88533147
132Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.88232727
133Asymmetric septal hypertrophy (HP:0001670)1.85635701
134Nephritis (HP:0000123)1.85595197
135Loss of speech (HP:0002371)1.85100761
136Mitral stenosis (HP:0001718)1.84943590
137Gingival bleeding (HP:0000225)1.84686973
138Increased CSF protein (HP:0002922)1.84479213
139Cardiomegaly (HP:0001640)1.83445918
140Reticulocytopenia (HP:0001896)1.83016754
141Villous atrophy (HP:0011473)1.82927350
142Abnormality of small intestinal villus morphology (HP:0011472)1.82927350
143Abnormality of complement system (HP:0005339)1.81790742
144Pulmonary embolism (HP:0002204)1.81510737
145Supranuclear gaze palsy (HP:0000605)1.80939463
146Conjunctival telangiectasia (HP:0000524)1.80261266
147Polycythemia (HP:0001901)1.80253261
148Bone pain (HP:0002653)1.78231924

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.97788876
2ERN13.61713004
3BLK3.59298511
4MAP3K143.12483185
5TYK23.03551644
6IRAK32.67692668
7TBK12.50201857
8GRK72.41505331
9STK102.24379501
10IRAK42.19877881
11LRRK22.17214900
12PRPF4B2.09965010
13IKBKB2.03854953
14MAP3K101.91746887
15RIPK41.88388538
16CSF1R1.87399570
17JAK31.80610517
18GRK61.79678825
19TRIB31.77592807
20TAOK21.72483026
21MST41.71252849
22FES1.66615772
23TAOK11.63243838
24CSK1.61970900
25KIT1.60229486
26DDR21.57285236
27MAP3K131.52578916
28PIM21.48856356
29NME21.48589119
30ZAP701.48313549
31IKBKE1.45453978
32JAK11.45416255
33RPS6KA41.45152414
34SYK1.42043742
35BTK1.39449176
36TGFBR21.39231227
37CHUK1.38789649
38CAMKK21.36643183
39TESK21.35657724
40BMPR21.34211435
41TXK1.33623625
42PIM11.33255929
43CDK121.22840759
44CDC42BPA1.18118204
45EPHB11.16465190
46ABL21.14857464
47TNK21.13972369
48MAP3K11.11647269
49TESK11.07488638
50NEK91.06124236
51SCYL21.06103255
52MATK1.05314609
53PKN21.05092202
54LYN1.04112998
55FGFR41.03523571
56FLT30.99995618
57SIK30.98743862
58MAP3K80.97542405
59PTK60.96434658
60MAP2K20.91384893
61MAP2K30.90459992
62BMX0.89100854
63STK40.88766932
64HCK0.84916018
65DYRK1B0.84681767
66IRAK20.82909668
67MAP3K30.82756263
68TLK10.82088058
69MST1R0.81166362
70ADRBK20.80943312
71PDK20.80599836
72MARK30.79868360
73LCK0.78880037
74PAK40.77691812
75NEK20.76588420
76EIF2AK30.75788561
77PDPK10.75768468
78EPHA20.75667206
79JAK20.74581004
80TEC0.74301286
81FRK0.70162055
82RIPK10.69806663
83TTN0.69516582
84MAP3K110.68611819
85TAOK30.68223712
86PDK10.67055511
87CDK60.66188040
88MAP3K50.66124951
89EIF2AK10.62221301
90FGR0.62087622
91DYRK30.60960774
92FGFR30.60813907
93MAPKAPK20.60663291
94IRAK10.60310698
95MAP2K60.58023767
96CLK10.57371487
97KDR0.56670987
98EPHA30.56122703
99RPS6KL10.55643828
100RPS6KB20.53047125
101CDK40.52760239
102ARAF0.52696017
103ITK0.51163039
104MAPK120.48420724
105EEF2K0.48226181
106DAPK20.46965870
107KSR20.46649190
108PRKCD0.46113137
109MAPK70.45086593
110FYN0.44420247
111RPS6KA20.41956127
112CAMKK10.41945883
113PRKCQ0.41587569
114ABL10.40900245
115EGFR0.40833492
116CAMK1D0.40811555
117STK30.40742857
118MAPKAPK30.40106576
119RPS6KA50.39710524
120MARK20.39396677
121TGFBR10.38884329
122CDK90.38819831
123SIK10.38605801
124SIK20.37867066
125ACVR1B0.37051993
126MAP2K10.36502661
127YES10.36481000
128RPS6KA60.36186538
129MAPK40.34640800
130HIPK20.33369266
131AURKB0.32969410
132MOS0.32225717
133PRKG20.31938614
134GRK10.30589303
135PRKD20.30289533
136ILK0.30063110
137MAPK110.29548259
138RPS6KC10.27854828
139MAP3K60.24781886
140CAMK1G0.22515014

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.88849196
2B cell receptor signaling pathway_Homo sapiens_hsa046622.88325447
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.79036711
4Autoimmune thyroid disease_Homo sapiens_hsa053202.62103900
5Primary immunodeficiency_Homo sapiens_hsa053402.48616623
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.37402417
7* Antigen processing and presentation_Homo sapiens_hsa046122.35139236
8Osteoclast differentiation_Homo sapiens_hsa043802.25933962
9Staphylococcus aureus infection_Homo sapiens_hsa051502.18729243
10Type I diabetes mellitus_Homo sapiens_hsa049402.16221283
11Other glycan degradation_Homo sapiens_hsa005112.12871125
12Toll-like receptor signaling pathway_Homo sapiens_hsa046202.08484903
13Lysosome_Homo sapiens_hsa041422.01715760
14Legionellosis_Homo sapiens_hsa051341.97420153
15Tuberculosis_Homo sapiens_hsa051521.91874278
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.83342266
17Apoptosis_Homo sapiens_hsa042101.81232543
18Pertussis_Homo sapiens_hsa051331.80647972
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.78709196
20Toxoplasmosis_Homo sapiens_hsa051451.73954357
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.70911101
22Measles_Homo sapiens_hsa051621.70187275
23Ribosome_Homo sapiens_hsa030101.60766701
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.58684997
25Herpes simplex infection_Homo sapiens_hsa051681.57659027
26Hematopoietic cell lineage_Homo sapiens_hsa046401.57307559
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.49712155
28Shigellosis_Homo sapiens_hsa051311.48004180
29Influenza A_Homo sapiens_hsa051641.47429386
30Collecting duct acid secretion_Homo sapiens_hsa049661.37521266
31TNF signaling pathway_Homo sapiens_hsa046681.36571540
32Malaria_Homo sapiens_hsa051441.30579761
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.26014552
34DNA replication_Homo sapiens_hsa030301.22704313
35Epstein-Barr virus infection_Homo sapiens_hsa051691.18100684
36Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.16613725
37Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.16108576
38Chemokine signaling pathway_Homo sapiens_hsa040621.15575830
39Graft-versus-host disease_Homo sapiens_hsa053321.14505796
40Salmonella infection_Homo sapiens_hsa051321.10507133
41Viral carcinogenesis_Homo sapiens_hsa052031.08193050
42Jak-STAT signaling pathway_Homo sapiens_hsa046301.07470825
43p53 signaling pathway_Homo sapiens_hsa041151.07065920
44Acute myeloid leukemia_Homo sapiens_hsa052211.06111510
45Hepatitis B_Homo sapiens_hsa051611.05307609
46Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.05112690
47Small cell lung cancer_Homo sapiens_hsa052221.04053669
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.03070302
49Allograft rejection_Homo sapiens_hsa053301.02037796
50Base excision repair_Homo sapiens_hsa034101.00790567
51Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.99613896
52Systemic lupus erythematosus_Homo sapiens_hsa053220.98731854
53Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.98616900
54Phagosome_Homo sapiens_hsa041450.94331121
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.93839769
56Viral myocarditis_Homo sapiens_hsa054160.90702834
57Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90668385
58Chronic myeloid leukemia_Homo sapiens_hsa052200.90293598
59Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.89835330
60Mismatch repair_Homo sapiens_hsa034300.88171399
61Hepatitis C_Homo sapiens_hsa051600.87615237
62AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86478672
63Proteasome_Homo sapiens_hsa030500.85659078
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.84335883
65Renin-angiotensin system_Homo sapiens_hsa046140.82944336
66Prion diseases_Homo sapiens_hsa050200.80352794
67Caffeine metabolism_Homo sapiens_hsa002320.77765382
68T cell receptor signaling pathway_Homo sapiens_hsa046600.76311673
69Pancreatic cancer_Homo sapiens_hsa052120.75359375
70Rheumatoid arthritis_Homo sapiens_hsa053230.74814852
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71118291
72Vibrio cholerae infection_Homo sapiens_hsa051100.70735044
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68743451
74Folate biosynthesis_Homo sapiens_hsa007900.68669370
75Pentose phosphate pathway_Homo sapiens_hsa000300.68084681
76HTLV-I infection_Homo sapiens_hsa051660.66641384
77Sphingolipid metabolism_Homo sapiens_hsa006000.66082661
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65768933
79Asthma_Homo sapiens_hsa053100.64678571
80Sulfur relay system_Homo sapiens_hsa041220.62182121
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61560945
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61017528
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.59709148
84Platelet activation_Homo sapiens_hsa046110.56879031
85Mineral absorption_Homo sapiens_hsa049780.55259917
86Fat digestion and absorption_Homo sapiens_hsa049750.53045972
87Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.52732904
88African trypanosomiasis_Homo sapiens_hsa051430.52466106
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52010820
90Amoebiasis_Homo sapiens_hsa051460.51683430
91One carbon pool by folate_Homo sapiens_hsa006700.51429536
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49494453
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48028462
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.46794881
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.46553799
96Complement and coagulation cascades_Homo sapiens_hsa046100.44595029
97Homologous recombination_Homo sapiens_hsa034400.43846920
98MicroRNAs in cancer_Homo sapiens_hsa052060.42717512
99Proteoglycans in cancer_Homo sapiens_hsa052050.41363530
100Adherens junction_Homo sapiens_hsa045200.40624892
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40590321
102Prolactin signaling pathway_Homo sapiens_hsa049170.39919736
103PPAR signaling pathway_Homo sapiens_hsa033200.38373697
104Primary bile acid biosynthesis_Homo sapiens_hsa001200.37673836
105HIF-1 signaling pathway_Homo sapiens_hsa040660.37138282
106Galactose metabolism_Homo sapiens_hsa000520.36997924
107VEGF signaling pathway_Homo sapiens_hsa043700.36669519
108Insulin resistance_Homo sapiens_hsa049310.36641568
109Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35067583
110Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33775938
111Fructose and mannose metabolism_Homo sapiens_hsa000510.33766760
112Non-small cell lung cancer_Homo sapiens_hsa052230.32556165
113Endocytosis_Homo sapiens_hsa041440.32540154
114Bladder cancer_Homo sapiens_hsa052190.32186701
115Sulfur metabolism_Homo sapiens_hsa009200.27715353
116Renal cell carcinoma_Homo sapiens_hsa052110.26933660
117Synaptic vesicle cycle_Homo sapiens_hsa047210.25079140
118Notch signaling pathway_Homo sapiens_hsa043300.20480127
119GnRH signaling pathway_Homo sapiens_hsa049120.18913593
120Phospholipase D signaling pathway_Homo sapiens_hsa040720.18533548
121Type II diabetes mellitus_Homo sapiens_hsa049300.15132656
122Carbohydrate digestion and absorption_Homo sapiens_hsa049730.14837336

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