IFI35

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.06636486
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.06636486
3antigen processing and presentation of endogenous antigen (GO:0019883)5.84043642
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.01936410
5* type I interferon signaling pathway (GO:0060337)4.96685465
6* cellular response to type I interferon (GO:0071357)4.96685465
7* response to type I interferon (GO:0034340)4.95386906
8positive regulation of interferon-alpha production (GO:0032727)4.39220635
9response to interferon-beta (GO:0035456)4.33199119
10negative regulation of interleukin-12 production (GO:0032695)4.23298031
11response to interferon-alpha (GO:0035455)4.19489823
12positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.18324117
13regulation of interferon-alpha production (GO:0032647)4.14902109
14cellular response to interferon-beta (GO:0035458)4.07346916
15negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.07018271
16negative regulation of cell killing (GO:0031342)4.07018271
17positive regulation of gamma-delta T cell activation (GO:0046645)3.89795685
18immunoglobulin mediated immune response (GO:0016064)3.81140655
19macrophage activation involved in immune response (GO:0002281)3.81104486
20interferon-gamma-mediated signaling pathway (GO:0060333)3.76102144
21negative regulation of viral genome replication (GO:0045071)3.73208224
22neutrophil activation involved in immune response (GO:0002283)3.69412918
23positive regulation of antigen processing and presentation (GO:0002579)3.62832664
24positive regulation of natural killer cell differentiation (GO:0032825)3.57355763
25regulation of RIG-I signaling pathway (GO:0039535)3.54361285
26detection of other organism (GO:0098543)3.52563586
27detection of bacterium (GO:0016045)3.52500388
28cellular response to exogenous dsRNA (GO:0071360)3.52141092
29regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.48701901
30negative regulation of cytokine production involved in immune response (GO:0002719)3.46708692
31regulation of type I interferon-mediated signaling pathway (GO:0060338)3.37271226
32positive regulation of type 2 immune response (GO:0002830)3.36153317
33antigen processing and presentation via MHC class Ib (GO:0002475)3.33827159
34regulation of chronic inflammatory response (GO:0002676)3.32512304
35regulation of T-helper 1 cell differentiation (GO:0045625)3.31117875
36NIK/NF-kappaB signaling (GO:0038061)3.27717909
37regulation of interferon-beta biosynthetic process (GO:0045357)3.24129842
38defense response to protozoan (GO:0042832)3.23972225
39natural killer cell mediated cytotoxicity (GO:0042267)3.23241189
40natural killer cell mediated immunity (GO:0002228)3.23241189
41regulation of antigen processing and presentation (GO:0002577)3.22552639
42B cell mediated immunity (GO:0019724)3.22309260
43response to peptidoglycan (GO:0032494)3.21053426
44positive regulation of interferon-beta production (GO:0032728)3.19343282
45cellular response to virus (GO:0098586)3.18730877
46positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.17298308
47cellular response to zinc ion (GO:0071294)3.16953140
48regulation of interleukin-12 biosynthetic process (GO:0045075)3.11860518
49myeloid dendritic cell activation (GO:0001773)3.10657944
50myeloid dendritic cell differentiation (GO:0043011)3.05517751
51regulation of T cell tolerance induction (GO:0002664)3.05042958
52regulation of vitamin D biosynthetic process (GO:0060556)3.04121712
53regulation of dendritic cell antigen processing and presentation (GO:0002604)3.03874595
54T cell migration (GO:0072678)3.00771956
55lipopolysaccharide-mediated signaling pathway (GO:0031663)3.00106191
56regulation of type 2 immune response (GO:0002828)2.98194207
57response to protozoan (GO:0001562)2.97785399
58ribosomal small subunit assembly (GO:0000028)2.97668179
59germinal center formation (GO:0002467)2.97471213
60lymphocyte chemotaxis (GO:0048247)2.97308039
61negative regulation of T cell mediated immunity (GO:0002710)2.97053472
62regulation of response to interferon-gamma (GO:0060330)2.96842385
63detection of external biotic stimulus (GO:0098581)2.96273635
64regulation of alpha-beta T cell proliferation (GO:0046640)2.95866341
65negative regulation of innate immune response (GO:0045824)2.95588725
66regulation of viral genome replication (GO:0045069)2.94985651
67response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.94641874
68response to host immune response (GO:0052572)2.94641874
69regulation of cytokine secretion involved in immune response (GO:0002739)2.93386218
70Arp2/3 complex-mediated actin nucleation (GO:0034314)2.91141864
71T-helper 1 type immune response (GO:0042088)2.90332682
72negative regulation of viral process (GO:0048525)2.89920450
73cellular response to interferon-gamma (GO:0071346)2.89862115
74positive regulation by symbiont of host defense response (GO:0052509)2.88446582
75modulation by symbiont of host defense response (GO:0052031)2.88446582
76modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.88446582
77modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.88446582
78positive regulation by organism of defense response of other organism involved in symbiotic interact2.88446582
79modulation by symbiont of host immune response (GO:0052553)2.88446582
80positive regulation of interleukin-12 production (GO:0032735)2.87689685
81negative thymic T cell selection (GO:0045060)2.86863878
82cellular response to interferon-alpha (GO:0035457)2.86825535
83negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.85769009
84regulation of T cell mediated cytotoxicity (GO:0001914)2.85315465
85positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.84097392
86response to interferon-gamma (GO:0034341)2.83961316
87positive regulation of alpha-beta T cell proliferation (GO:0046641)2.83767622
88neutrophil activation (GO:0042119)2.83742600
89regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.82989006
90regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.82922752
91JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.82588290
92granulocyte activation (GO:0036230)2.82480975
93regulation of gamma-delta T cell differentiation (GO:0045586)2.80826567
94regulation of activation of Janus kinase activity (GO:0010533)2.79330716
95negative T cell selection (GO:0043383)2.79197211
96respiratory burst (GO:0045730)2.79195864
97regulation of natural killer cell differentiation (GO:0032823)2.78406375
98defense response to virus (GO:0051607)2.76469771
99regulation of chemokine biosynthetic process (GO:0045073)2.75827090
100negative regulation of production of molecular mediator of immune response (GO:0002701)2.75295803
101regulation of inflammatory response to antigenic stimulus (GO:0002861)2.75022966
102positive regulation of defense response to virus by host (GO:0002230)2.73090740
103regulation of gamma-delta T cell activation (GO:0046643)2.71891509
104regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.71282819
105regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.70712997
106positive regulation of humoral immune response (GO:0002922)2.70622648
107regulation of B cell receptor signaling pathway (GO:0050855)2.69819943
108negative regulation of lymphocyte mediated immunity (GO:0002707)2.69652223
109regulation of tolerance induction (GO:0002643)2.66697375
110regulation of defense response to virus by host (GO:0050691)2.66441231
111detection of molecule of bacterial origin (GO:0032490)2.66283624
112dendritic cell differentiation (GO:0097028)2.66051992
113positive regulation of NF-kappaB import into nucleus (GO:0042346)2.64949194
114positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.63202317
115negative regulation of leukocyte mediated immunity (GO:0002704)2.63142716
116regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.58113779
117natural killer cell activation (GO:0030101)2.57405060
118hydrogen peroxide biosynthetic process (GO:0050665)2.55271252
119regulation of hypersensitivity (GO:0002883)2.52876941
120cellular extravasation (GO:0045123)2.51641244
121regulation of interferon-beta production (GO:0032648)2.51177268
122negative regulation of myeloid cell apoptotic process (GO:0033033)2.49379026
123positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.48258327
124positive regulation of T cell mediated cytotoxicity (GO:0001916)2.46501606
125positive regulation of chemokine biosynthetic process (GO:0045080)2.46025446
126regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.45682207
127leukocyte mediated cytotoxicity (GO:0001909)2.45330412
128leukocyte aggregation (GO:0070486)2.45281889
129regulation of interleukin-12 production (GO:0032655)2.44538971
130positive regulation of interleukin-17 production (GO:0032740)2.43988374
131positive regulation of B cell differentiation (GO:0045579)2.43551122
132positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.41906665
133negative regulation of type I interferon production (GO:0032480)2.39783088
134myeloid cell activation involved in immune response (GO:0002275)2.38272427
135negative regulation of nitric oxide biosynthetic process (GO:0045019)2.38225270

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* IRF8_22096565_ChIP-ChIP_GC-B_Human6.66522018
2* IRF8_21731497_ChIP-ChIP_J774_Mouse4.93711160
3* IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.72299588
4* IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.55379589
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.03619150
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.19439714
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.89518065
8* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.82379942
9* IRF8_27001747_Chip-Seq_BMDM_Mouse2.80247524
10SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.71848344
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.70698330
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.51677006
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.50098421
14RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.47795114
15GATA1_22025678_ChIP-Seq_K562_Human2.42866412
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.29410998
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.26215695
18* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.15418750
19TP63_17297297_ChIP-ChIP_HaCaT_Human2.10629750
20* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.06701863
21ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.05023601
22SPI1_23547873_ChIP-Seq_NB4_Human1.95149080
23EGR1_23403033_ChIP-Seq_LIVER_Mouse1.90747556
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.90047537
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.89965861
26MYB_26560356_Chip-Seq_TH2_Human1.88923182
27FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.86170145
28EGR1_19374776_ChIP-ChIP_THP-1_Human1.83864910
29MAF_26560356_Chip-Seq_TH1_Human1.83170216
30PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.79643177
31EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.65095358
32MYB_26560356_Chip-Seq_TH1_Human1.63161910
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.62980330
34BRD4_27068464_Chip-Seq_AML-cells_Mouse1.58802907
35E2F7_22180533_ChIP-Seq_HELA_Human1.54099785
36CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.52043698
37Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.51827918
38PPARA_22158963_ChIP-Seq_LIVER_Mouse1.51679743
39FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.48954763
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.48214826
41VDR_24763502_ChIP-Seq_THP-1_Human1.46164144
42RXR_22158963_ChIP-Seq_LIVER_Mouse1.44945885
43VDR_24787735_ChIP-Seq_THP-1_Human1.41954155
44SCL_19346495_ChIP-Seq_HPC-7_Human1.41577948
45BCL6_27268052_Chip-Seq_Bcells_Human1.41371921
46* VDR_21846776_ChIP-Seq_THP-1_Human1.41170054
47ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40533685
48STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.38334279
49CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.37251413
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.36287744
51GATA2_22383799_ChIP-Seq_G1ME_Mouse1.35887547
52CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.34458831
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.33011012
54RUNX_20019798_ChIP-Seq_JUKART_Human1.31604688
55ELF1_17652178_ChIP-ChIP_JURKAT_Human1.31066924
56LXR_22292898_ChIP-Seq_THP-1_Human1.29026337
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28346727
58UTX_26944678_Chip-Seq_JUKART_Human1.27540210
59NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.24778842
60MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.24306353
61VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.24104299
62BCOR_27268052_Chip-Seq_Bcells_Human1.22792743
63LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.21318585
64* MAF_26560356_Chip-Seq_TH2_Human1.20837818
65* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18405738
66GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.16945853
67PU_27001747_Chip-Seq_BMDM_Mouse1.16689391
68GATA1_22383799_ChIP-Seq_G1ME_Mouse1.16396678
69MYC_22102868_ChIP-Seq_BL_Human1.15331230
70ELF1_20517297_ChIP-Seq_JURKAT_Human1.14376395
71STAT1_20625510_ChIP-Seq_HELA_Human1.12562520
72GABP_17652178_ChIP-ChIP_JURKAT_Human1.12294440
73ERG_20887958_ChIP-Seq_HPC-7_Mouse1.12154892
74CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.11989158
75SPI1_23127762_ChIP-Seq_K562_Human1.11317445
76CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10800849
77CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10204898
78SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.09378582
79E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.09171784
80GATA1_19941827_ChIP-Seq_MEL_Mouse1.08613713
81GATA3_27048872_Chip-Seq_THYMUS_Human1.07602308
82LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.07257640
83TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.06269332
84KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05850452
85PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05292572
86VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.03887634
87HOXB4_20404135_ChIP-ChIP_EML_Mouse1.03338731
88GATA3_26560356_Chip-Seq_TH2_Human1.03312968
89CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.02816984
90PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02763152
91PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01319319
92TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00335196
93SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99608636
94ELK3_25401928_ChIP-Seq_HUVEC_Human0.96893231
95NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.96456803
96VDR_23849224_ChIP-Seq_CD4+_Human0.96331862
97LXR_22158963_ChIP-Seq_LIVER_Mouse0.96128084
98PU.1_20513432_ChIP-Seq_Bcells_Mouse0.94863702
99NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.91666693
100KDM2B_26808549_Chip-Seq_DND41_Human0.90320157
101KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.88934533
102IKZF1_21737484_ChIP-ChIP_HCT116_Human0.88616264
103SRF_21415370_ChIP-Seq_HL-1_Mouse0.87915916
104GATA2_21666600_ChIP-Seq_HMVEC_Human0.87761167
105TCF7_22412390_ChIP-Seq_EML_Mouse0.87615037
106TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84545359
107HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.84544761
108P300_27268052_Chip-Seq_Bcells_Human0.84261110
109TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84017802
110EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.83915235
111SA1_27219007_Chip-Seq_Bcells_Human0.83665384
112CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.83655300
113STAT3_1855785_ChIP-Seq_MESCs_Mouse0.83402737
114EGR1_19032775_ChIP-ChIP_M12_Human0.82812657
115* CTCF_26484167_Chip-Seq_Bcells_Mouse0.82675145
116PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82466848
117ELK1_19687146_ChIP-ChIP_HELA_Human0.82099043
118HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.82012649
119GATA1_19941826_ChIP-Seq_K562_Human0.80512901
120CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.79776692
121GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.79538174
122TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.79401430
123TFEB_21752829_ChIP-Seq_HELA_Human0.78385621
124SPI1_20517297_ChIP-Seq_HL60_Human0.77508471

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.45061112
2MP0009785_altered_susceptibility_to3.65778673
3MP0003724_increased_susceptibility_to3.36553496
4MP0000685_abnormal_immune_system3.32766138
5MP0005671_abnormal_response_to3.11260727
6MP0002148_abnormal_hypersensitivity_rea2.99520242
7MP0003436_decreased_susceptibility_to2.82385599
8MP0005025_abnormal_response_to2.79979838
9MP0005387_immune_system_phenotype2.79259621
10MP0001790_abnormal_immune_system2.79259621
11MP0005000_abnormal_immune_tolerance2.68741838
12MP0006082_CNS_inflammation2.53113886
13MP0001800_abnormal_humoral_immune2.52593893
14MP0002166_altered_tumor_susceptibility2.38174130
15MP0002452_abnormal_antigen_presenting2.36331381
16MP0002723_abnormal_immune_serum2.35870357
17MP0002419_abnormal_innate_immunity2.35805025
18MP0001819_abnormal_immune_cell2.17297688
19MP0002420_abnormal_adaptive_immunity2.14929084
20MP0002138_abnormal_hepatobiliary_system2.14058688
21MP0003763_abnormal_thymus_physiology2.11317480
22MP0002006_tumorigenesis2.09790761
23MP0010155_abnormal_intestine_physiology1.94797413
24MP0003806_abnormal_nucleotide_metabolis1.88945255
25MP0003303_peritoneal_inflammation1.86843251
26MP0001853_heart_inflammation1.84948252
27MP0009333_abnormal_splenocyte_physiolog1.82641925
28MP0004947_skin_inflammation1.81691778
29MP0002405_respiratory_system_inflammati1.79636734
30MP0001845_abnormal_inflammatory_respons1.78803898
31MP0004510_myositis1.75121294
32MP0009764_decreased_sensitivity_to1.74479125
33MP0002398_abnormal_bone_marrow1.73099934
34MP0005464_abnormal_platelet_physiology1.72876080
35MP0000716_abnormal_immune_system1.72490502
36MP0008469_abnormal_protein_level1.68626071
37MP0003191_abnormal_cellular_cholesterol1.62346546
38MP0001533_abnormal_skeleton_physiology1.57961289
39MP0001873_stomach_inflammation1.51942742
40MP0001545_abnormal_hematopoietic_system1.49296630
41MP0005397_hematopoietic_system_phenotyp1.49296630
42MP0009840_abnormal_foam_cell1.48153552
43MP0002429_abnormal_blood_cell1.44797389
44MP0000689_abnormal_spleen_morphology1.42408423
45MP0002722_abnormal_immune_system1.41653543
46MP0003300_gastrointestinal_ulcer1.40242643
47MP0002396_abnormal_hematopoietic_system1.35710780
48MP0003186_abnormal_redox_activity1.35346457
49MP0000858_altered_metastatic_potential1.35310448
50MP0005451_abnormal_body_composition1.30942241
51MP0005310_abnormal_salivary_gland1.26233678
52MP0005360_urolithiasis1.26010794
53MP0005058_abnormal_lysosome_morphology1.25666011
54MP0003448_altered_tumor_morphology1.23054447
55MP0000604_amyloidosis1.20989324
56MP0003866_abnormal_defecation1.19842643
57MP0002254_reproductive_system_inflammat1.19792762
58MP0000343_altered_response_to1.13414390
59MP0004782_abnormal_surfactant_physiolog1.07434971
60MP0009763_increased_sensitivity_to1.07309226
61MP0003183_abnormal_peptide_metabolism1.07178753
62MP0001348_abnormal_lacrimal_gland1.03691342
63MP0002277_abnormal_respiratory_mucosa1.03621389
64MP0002132_abnormal_respiratory_system1.01984820
65MP0000490_abnormal_crypts_of1.00813506
66MP0003195_calcinosis0.99812665
67MP0009278_abnormal_bone_marrow0.95740633
68MP0008004_abnormal_stomach_pH0.95281721
69MP0002933_joint_inflammation0.95022019
70MP0000703_abnormal_thymus_morphology0.94847969
71MP0003690_abnormal_glial_cell0.93547419
72MP0002139_abnormal_hepatobiliary_system0.91846407
73MP0003656_abnormal_erythrocyte_physiolo0.91210572
74MP0005085_abnormal_gallbladder_physiolo0.89445602
75MP0002163_abnormal_gland_morphology0.88888545
76MP0002998_abnormal_bone_remodeling0.88441696
77MP0002332_abnormal_exercise_endurance0.88421714
78MP0005365_abnormal_bile_salt0.86315342
79MP0004808_abnormal_hematopoietic_stem0.86248879
80MP0005083_abnormal_biliary_tract0.85374117
81MP0010352_gastrointestinal_tract_polyps0.85061652
82MP0005164_abnormal_response_to0.84888521
83MP0000609_abnormal_liver_physiology0.84856029
84MP0010307_abnormal_tumor_latency0.83261629
85MP0000465_gastrointestinal_hemorrhage0.81582597
86MP0009643_abnormal_urine_homeostasis0.81412913
87MP0001542_abnormal_bone_strength0.80274704
88MP0003453_abnormal_keratinocyte_physiol0.79643047
89MP0005319_abnormal_enzyme/_coenzyme0.79586013
90MP0003828_pulmonary_edema0.79419839
91MP0005167_abnormal_blood-brain_barrier0.77004423
92MP0003075_altered_response_to0.76463428
93MP0002136_abnormal_kidney_physiology0.75042434
94MP0008875_abnormal_xenobiotic_pharmacok0.74219425
95MP0002019_abnormal_tumor_incidence0.73718619
96MP0004883_abnormal_blood_vessel0.73677517
97MP0000249_abnormal_blood_vessel0.72384134
98MP0003045_fibrosis0.72334559
99MP0009379_abnormal_foot_pigmentation0.72113311
100MP0005165_increased_susceptibility_to0.71651856
101MP0008260_abnormal_autophagy0.71391654
102MP0005023_abnormal_wound_healing0.70880516
103MP0003252_abnormal_bile_duct0.70609494
104MP0001764_abnormal_homeostasis0.70489046
105MP0003172_abnormal_lysosome_physiology0.69462176
106MP0005166_decreased_susceptibility_to0.68711929
107MP0003566_abnormal_cell_adhesion0.68650600
108MP0002693_abnormal_pancreas_physiology0.68596820
109MP0006054_spinal_hemorrhage0.67981217
110MP0005390_skeleton_phenotype0.67437359
111MP0005174_abnormal_tail_pigmentation0.65029057
112MP0008874_decreased_physiological_sensi0.64719080
113MP0009765_abnormal_xenobiotic_induced0.63899540
114MP0005584_abnormal_enzyme/coenzyme_acti0.62743019
115MP0000598_abnormal_liver_morphology0.62586227
116MP0001851_eye_inflammation0.62472606
117MP0001663_abnormal_digestive_system0.60691347
118MP0003795_abnormal_bone_structure0.60588089

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)5.07173052
2Eczematoid dermatitis (HP:0000976)5.01632571
3Autoimmune thrombocytopenia (HP:0001973)4.69668800
4Recurrent abscess formation (HP:0002722)4.59421952
5Abnormality of liposaccharide metabolism (HP:0010968)4.38238291
6Abnormality of glycosphingolipid metabolism (HP:0004343)4.38238291
7Abnormality of glycolipid metabolism (HP:0010969)4.38238291
8Recurrent bacterial skin infections (HP:0005406)4.27125684
9Chronic otitis media (HP:0000389)4.04633766
10Myositis (HP:0100614)3.95499562
11Increased IgM level (HP:0003496)3.79875411
12Recurrent gram-negative bacterial infections (HP:0005420)3.73807606
13Recurrent fungal infections (HP:0002841)3.60313900
14Recurrent bronchitis (HP:0002837)3.47255343
15Autoimmune hemolytic anemia (HP:0001890)3.43782144
16Vasculitis (HP:0002633)3.39762164
17Recurrent viral infections (HP:0004429)3.36807890
18Abnormality of macrophages (HP:0004311)3.32235267
19Pustule (HP:0200039)3.31269078
20Orchitis (HP:0100796)3.28626896
21Nasal polyposis (HP:0100582)3.27378111
22Recurrent skin infections (HP:0001581)3.24014691
23Abnormality of the nasal mucosa (HP:0000433)3.23961510
24Dysostosis multiplex (HP:0000943)3.10205624
25Interstitial pulmonary disease (HP:0006530)3.09747264
26Recurrent cutaneous fungal infections (HP:0011370)3.08248330
27Chronic mucocutaneous candidiasis (HP:0002728)3.08248330
28Loss of speech (HP:0002371)3.03775343
29Thrombocytosis (HP:0001894)3.02021005
30Hypergammaglobulinemia (HP:0010702)3.01033109
31Mediastinal lymphadenopathy (HP:0100721)2.96196844
32Abnormality of T cell number (HP:0011839)2.93122686
33Increased cerebral lipofuscin (HP:0011813)2.92490824
34Vacuolated lymphocytes (HP:0001922)2.91186471
35Retrobulbar optic neuritis (HP:0100654)2.90280918
36Optic neuritis (HP:0100653)2.90280918
37Abnormality of T cell physiology (HP:0011840)2.84306698
38Abnormality of T cells (HP:0002843)2.82600975
39Basal ganglia calcification (HP:0002135)2.78677342
40Petechiae (HP:0000967)2.77610940
41Systemic lupus erythematosus (HP:0002725)2.76319454
42Periodontitis (HP:0000704)2.72693684
43Gangrene (HP:0100758)2.68870326
44Abnormal delayed hypersensitivity skin test (HP:0002963)2.63225270
45Gastrointestinal infarctions (HP:0005244)2.62157908
46Stomatitis (HP:0010280)2.61638141
47Gingivitis (HP:0000230)2.59785751
48IgG deficiency (HP:0004315)2.58418156
49T lymphocytopenia (HP:0005403)2.57719612
50IgM deficiency (HP:0002850)2.57510160
51Increased neuronal autofluorescent lipopigment (HP:0002074)2.55292291
52Abnormality of the pleura (HP:0002103)2.54016347
53Chronic diarrhea (HP:0002028)2.53295854
54Meningitis (HP:0001287)2.49662873
55Gingival bleeding (HP:0000225)2.49414904
56Abnormality of polysaccharide metabolism (HP:0011012)2.45318882
57Abnormality of glycosaminoglycan metabolism (HP:0004371)2.45318882
58Abnormality of mucopolysaccharide metabolism (HP:0011020)2.45318882
59Leukocytosis (HP:0001974)2.44191033
60Cellulitis (HP:0100658)2.43280219
61Spontaneous hematomas (HP:0007420)2.42181235
62Increased IgE level (HP:0003212)2.39785208
63Urticaria (HP:0001025)2.39557373
64Eosinophilia (HP:0001880)2.39102441
65Agammaglobulinemia (HP:0004432)2.36482376
66Obstructive lung disease (HP:0006536)2.35875374
67Chronic obstructive pulmonary disease (HP:0006510)2.35875374
68Abnormality of cells of the lymphoid lineage (HP:0012140)2.35170781
69Progressive neurologic deterioration (HP:0002344)2.33418367
70Hepatosplenomegaly (HP:0001433)2.32706928
71Pulmonary infiltrates (HP:0002113)2.31865410
72Abnormality of B cell number (HP:0010975)2.31525636
73Hemoptysis (HP:0002105)2.31322759
74Pulmonary embolism (HP:0002204)2.30627380
75Chronic sinusitis (HP:0011109)2.27453610
76Urinary glycosaminoglycan excretion (HP:0003541)2.27019470
77Mucopolysacchariduria (HP:0008155)2.27019470
78Lymphopenia (HP:0001888)2.26912596
79Abnormality of eosinophils (HP:0001879)2.25512279
80Tetraparesis (HP:0002273)2.25162085
81Granulocytopenia (HP:0001913)2.23629744
82Abnormality of the pericardium (HP:0001697)2.23232818
83Joint swelling (HP:0001386)2.22944304
84Chest pain (HP:0100749)2.22920378
85IgA deficiency (HP:0002720)2.22888650
86Combined immunodeficiency (HP:0005387)2.22690752
87Inflammation of the large intestine (HP:0002037)2.21735752
88Abnormality of iron homeostasis (HP:0011031)2.21673509
89Arterial thrombosis (HP:0004420)2.21340135
90Amyloidosis (HP:0011034)2.19467391
91Epistaxis (HP:0000421)2.19295591
92Polyneuropathy (HP:0001271)2.18760835
93Disinhibition (HP:0000734)2.18413971
94Severe combined immunodeficiency (HP:0004430)2.17803270
95Purpura (HP:0000979)2.17171222
96Colitis (HP:0002583)2.15322908
97Episodic fever (HP:0001954)2.14310805
98Osteomyelitis (HP:0002754)2.11675787
99Gastrointestinal stroma tumor (HP:0100723)2.11067505
100Malnutrition (HP:0004395)2.09779440
101Gastrointestinal inflammation (HP:0004386)2.09524634
102Hypertensive crisis (HP:0100735)2.09358730
103Glomerulonephritis (HP:0000099)2.08505018
104Anorexia (HP:0002039)2.08290949
105Skin ulcer (HP:0200042)2.08055626
106Encephalitis (HP:0002383)2.07857225
107Arthralgia (HP:0002829)2.07374349
108Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.05860453
109Skin rash (HP:0000988)2.03410775
110B lymphocytopenia (HP:0010976)2.02751564
111Thyroiditis (HP:0100646)2.02397940
112Glomerulopathy (HP:0100820)2.02378805
113Emphysema (HP:0002097)2.02108733
114Hematochezia (HP:0002573)2.01492390
115Recurrent lower respiratory tract infections (HP:0002783)2.01429775
116Increased serum ferritin (HP:0003281)2.00816391
117Recurrent pneumonia (HP:0006532)2.00383775
118Keratoconjunctivitis sicca (HP:0001097)1.98044233
119Joint hemorrhage (HP:0005261)1.97986417
120Poor head control (HP:0002421)1.96578614
121Premature loss of primary teeth (HP:0006323)1.96390310
122Keratoconjunctivitis (HP:0001096)1.95078874
123Myocardial infarction (HP:0001658)1.91719078
124Vertebral compression fractures (HP:0002953)1.91082642
125Nausea (HP:0002018)1.88483767
126Prolonged bleeding time (HP:0003010)1.87430353
127Bronchitis (HP:0012387)1.86233371
128Panhypogammaglobulinemia (HP:0003139)1.85104506
129Abnormality of cells of the erythroid lineage (HP:0012130)1.84232865
130Cheilitis (HP:0100825)1.83418823
131Reduced antithrombin III activity (HP:0001976)1.83111440
132Microcytic anemia (HP:0001935)1.83015192
133Pallor (HP:0000980)1.83012860

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K143.53726360
2TYK23.48685806
3TBK13.45020742
4MAP4K13.40145065
5IKBKE3.19750512
6JAK32.90592742
7NME22.75611198
8BLK2.66009067
9TXK2.45132903
10KIT2.44864459
11FGFR42.42906808
12PIM22.42854470
13IRAK42.37688394
14IKBKB2.21613290
15JAK12.19036525
16IRAK32.17947918
17ERN12.16709162
18ZAP702.00438849
19TAOK21.88436275
20KDR1.76142571
21MST41.71212766
22TEC1.57841634
23CSK1.51188891
24PRPF4B1.50762453
25TAOK11.42446947
26SYK1.42166122
27BTK1.41230993
28NEK91.36859693
29PBK1.36706145
30TNK21.35583744
31BMPR21.31790803
32CHUK1.28337373
33FGR1.20954739
34TAOK31.20879275
35MAP3K131.20198197
36RPS6KA41.20027089
37NLK1.19478934
38EPHA31.18914884
39FGFR31.18547929
40RIPK41.17531229
41TGFBR21.13213817
42FLT31.10924351
43STK101.10699023
44PIM11.09823151
45LCK1.09397746
46CSF1R1.06005635
47EPHB11.04347559
48LYN0.98589726
49LRRK20.98126571
50HCK0.97802900
51SIK30.96024064
52MATK0.93425527
53EIF2AK10.92860946
54ITK0.92567387
55JAK20.90596300
56DDR20.88993330
57EIF2AK20.88778028
58MAP3K110.87230492
59MOS0.84978218
60MST1R0.83328917
61TGFBR10.83249412
62TRPM70.83137625
63CDC42BPA0.81532486
64STK40.76577969
65EIF2AK30.72274985
66MAP2K30.69848615
67TESK10.69617260
68FRK0.67201902
69PIK3CG0.63336652
70NUAK10.62764158
71MAPK110.62481353
72GRK60.61549801
73ACVR1B0.60194598
74ARAF0.58371556
75IRAK10.57940460
76ABL20.56695683
77SIK20.56309012
78PRKCD0.55495485
79NME10.55262954
80IRAK20.55172882
81MARK30.54229401
82RPS6KB20.54221551
83TIE10.53760759
84PDK10.53001201
85PRKG20.51486587
86PTK60.50752954
87MYLK0.50187781
88TLK10.50130378
89PRKCQ0.49219686
90MAP3K30.46730939
91MAPK70.45725835
92MAPKAPK20.43531689
93STK240.42987711
94FES0.42835686
95ABL10.42307610
96STK160.41478191
97PDPK10.41326879
98MAP3K50.40771406
99VRK10.40497652
100TESK20.39661452
101MAP2K60.39252393
102RPS6KA50.39169058
103CAMKK20.38835989
104PASK0.38768752
105BCKDK0.37964778
106ADRBK20.37065412
107PRKD20.36377714
108MAPKAPK30.36217415
109FYN0.36053718
110DAPK10.34720997
111MAP2K20.34356435
112MAP3K10.33684589
113RIPK10.31165742
114GRK70.30585647
115DAPK30.30140906
116DAPK20.29975299
117MAPK40.28731507
118BMX0.28519267
119TRIB30.26646784
120HIPK20.25696912
121ZAK0.25605884
122MAP3K120.24954569
123TTN0.24800346
124PKN10.23641914
125SMG10.21851902
126INSR0.19458697
127MAPK30.16518808
128CDK40.15954114

Predicted pathways (KEGG)

RankGene SetZ-score
1Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.23143798
2Graft-versus-host disease_Homo sapiens_hsa053322.90381643
3Allograft rejection_Homo sapiens_hsa053302.87429321
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.71199590
5Primary immunodeficiency_Homo sapiens_hsa053402.67777303
6Leishmaniasis_Homo sapiens_hsa051402.63865784
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.57486834
8RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.53418836
9Measles_Homo sapiens_hsa051622.45651263
10Toll-like receptor signaling pathway_Homo sapiens_hsa046202.31211632
11Antigen processing and presentation_Homo sapiens_hsa046122.12396850
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.10813800
13Staphylococcus aureus infection_Homo sapiens_hsa051502.07698101
14Legionellosis_Homo sapiens_hsa051342.01339458
15Herpes simplex infection_Homo sapiens_hsa051681.93035328
16Influenza A_Homo sapiens_hsa051641.86919978
17Ribosome_Homo sapiens_hsa030101.84004664
18Pertussis_Homo sapiens_hsa051331.80421546
19Proteasome_Homo sapiens_hsa030501.80268235
20Malaria_Homo sapiens_hsa051441.72748425
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.71237642
22Osteoclast differentiation_Homo sapiens_hsa043801.60788916
23Hematopoietic cell lineage_Homo sapiens_hsa046401.58902897
24Asthma_Homo sapiens_hsa053101.49380541
25TNF signaling pathway_Homo sapiens_hsa046681.47823943
26Autoimmune thyroid disease_Homo sapiens_hsa053201.47758808
27Toxoplasmosis_Homo sapiens_hsa051451.46272953
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.46126326
29Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.40697887
30Type I diabetes mellitus_Homo sapiens_hsa049401.40433721
31Apoptosis_Homo sapiens_hsa042101.33522514
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.32612278
33Caffeine metabolism_Homo sapiens_hsa002321.32124554
34Tuberculosis_Homo sapiens_hsa051521.30872677
35Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.26863081
36Viral myocarditis_Homo sapiens_hsa054161.22368998
37Rheumatoid arthritis_Homo sapiens_hsa053231.20995284
38B cell receptor signaling pathway_Homo sapiens_hsa046621.19588813
39African trypanosomiasis_Homo sapiens_hsa051431.19313268
40Folate biosynthesis_Homo sapiens_hsa007901.12582627
41Other glycan degradation_Homo sapiens_hsa005111.12239830
42Hepatitis C_Homo sapiens_hsa051601.11885501
43Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.10775289
44Hepatitis B_Homo sapiens_hsa051611.01902331
45Salmonella infection_Homo sapiens_hsa051320.97753541
46Pentose and glucuronate interconversions_Homo sapiens_hsa000400.96573520
47Shigellosis_Homo sapiens_hsa051310.93691245
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.88253055
49Chemokine signaling pathway_Homo sapiens_hsa040620.86405202
50T cell receptor signaling pathway_Homo sapiens_hsa046600.85109734
51Complement and coagulation cascades_Homo sapiens_hsa046100.82682669
52Lysosome_Homo sapiens_hsa041420.82218709
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81273380
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80429336
55Systemic lupus erythematosus_Homo sapiens_hsa053220.78883380
56Sulfur metabolism_Homo sapiens_hsa009200.76758808
57Pentose phosphate pathway_Homo sapiens_hsa000300.76236031
58Sulfur relay system_Homo sapiens_hsa041220.73818150
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73028733
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.70054963
61Primary bile acid biosynthesis_Homo sapiens_hsa001200.70015427
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.69534290
63DNA replication_Homo sapiens_hsa030300.67303556
64p53 signaling pathway_Homo sapiens_hsa041150.66027705
65Histidine metabolism_Homo sapiens_hsa003400.64717231
66Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.63978307
67Epstein-Barr virus infection_Homo sapiens_hsa051690.63496628
68Acute myeloid leukemia_Homo sapiens_hsa052210.62029713
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60240331
70Drug metabolism - other enzymes_Homo sapiens_hsa009830.60126200
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59231390
72Tryptophan metabolism_Homo sapiens_hsa003800.55243370
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55220150
74Phagosome_Homo sapiens_hsa041450.54742719
75Pyrimidine metabolism_Homo sapiens_hsa002400.54420500
76Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54031183
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52421239
78Glycosaminoglycan degradation_Homo sapiens_hsa005310.51959044
79Protein export_Homo sapiens_hsa030600.51931885
80Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50162845
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48760573
82Base excision repair_Homo sapiens_hsa034100.48453488
83Prolactin signaling pathway_Homo sapiens_hsa049170.47756123
84Prion diseases_Homo sapiens_hsa050200.46733152
85Peroxisome_Homo sapiens_hsa041460.45801758
86ABC transporters_Homo sapiens_hsa020100.44245779
87Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43501506
88Collecting duct acid secretion_Homo sapiens_hsa049660.42750315
89Phenylalanine metabolism_Homo sapiens_hsa003600.42059970
90HTLV-I infection_Homo sapiens_hsa051660.42019134
91Galactose metabolism_Homo sapiens_hsa000520.41836131
92Small cell lung cancer_Homo sapiens_hsa052220.41095467
93Viral carcinogenesis_Homo sapiens_hsa052030.39552891
94Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38980010
95Amoebiasis_Homo sapiens_hsa051460.38904325
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38762161
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.38640347
98One carbon pool by folate_Homo sapiens_hsa006700.38336289
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38063008
100Vitamin digestion and absorption_Homo sapiens_hsa049770.36024686
101Chemical carcinogenesis_Homo sapiens_hsa052040.35336614
102Arginine biosynthesis_Homo sapiens_hsa002200.34811259
103Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33900468
104Arachidonic acid metabolism_Homo sapiens_hsa005900.32627374
105Platelet activation_Homo sapiens_hsa046110.32607074
106Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32511551
107Sphingolipid metabolism_Homo sapiens_hsa006000.31703882
108Fructose and mannose metabolism_Homo sapiens_hsa000510.29701750
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29369429
110Selenocompound metabolism_Homo sapiens_hsa004500.28258294
111Fatty acid degradation_Homo sapiens_hsa000710.26524012
112Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26286086
113RNA polymerase_Homo sapiens_hsa030200.26204701
114alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26199507
115Bladder cancer_Homo sapiens_hsa052190.21119545
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.18988009
117Endocytosis_Homo sapiens_hsa041440.17424007
118Mineral absorption_Homo sapiens_hsa049780.17289523
119Insulin resistance_Homo sapiens_hsa049310.15891208
120PPAR signaling pathway_Homo sapiens_hsa033200.13653365
121Renin-angiotensin system_Homo sapiens_hsa046140.12255190
122VEGF signaling pathway_Homo sapiens_hsa043700.11259637
123Glutathione metabolism_Homo sapiens_hsa004800.09995712
124Cyanoamino acid metabolism_Homo sapiens_hsa004600.09040424
125Type II diabetes mellitus_Homo sapiens_hsa049300.05572632
126Pancreatic cancer_Homo sapiens_hsa052120.04417366
127Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.04237747

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