IFI6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene was first identified as one of the many genes induced by interferon. The encoded protein may play a critical role in the regulation of apoptosis. A minisatellite that consists of 26 repeats of a 12 nucleotide repeating element resembling the mammalian splice donor consensus sequence begins near the end of the second exon. Alternatively spliced transcript variants that encode different isoforms by using the two downstream repeat units as splice donor sites have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* cellular response to type I interferon (GO:0071357)7.32175921
2* type I interferon signaling pathway (GO:0060337)7.32175921
3* response to type I interferon (GO:0034340)7.23165451
4response to interferon-alpha (GO:0035455)6.20148072
5negative regulation of viral genome replication (GO:0045071)6.04878739
6cellular response to interferon-alpha (GO:0035457)5.47184398
7response to interferon-beta (GO:0035456)5.34674104
8antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.90562925
9antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.81766159
10antigen processing and presentation of endogenous antigen (GO:0019883)4.51624290
11interferon-gamma-mediated signaling pathway (GO:0060333)4.29528624
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.24678252
13immunoglobulin mediated immune response (GO:0016064)4.05804401
14regulation of interferon-alpha production (GO:0032647)4.03765847
15regulation of viral genome replication (GO:0045069)4.01218394
16negative regulation of viral process (GO:0048525)3.96566901
17positive regulation of interferon-alpha production (GO:0032727)3.90652916
18cellular response to exogenous dsRNA (GO:0071360)3.84613061
19cellular response to interferon-beta (GO:0035458)3.76495522
20regulation of type I interferon-mediated signaling pathway (GO:0060338)3.71180755
21defense response to virus (GO:0051607)3.61904228
22lipopolysaccharide-mediated signaling pathway (GO:0031663)3.55147082
23negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.54968357
24negative regulation of cell killing (GO:0031342)3.54968357
25response to peptidoglycan (GO:0032494)3.54821045
26cellular response to virus (GO:0098586)3.52653871
27negative regulation of interleukin-12 production (GO:0032695)3.46210335
28cellular response to interferon-gamma (GO:0071346)3.43276167
29macrophage activation involved in immune response (GO:0002281)3.42629477
30response to interferon-gamma (GO:0034341)3.39542505
31negative regulation of cytokine production involved in immune response (GO:0002719)3.31855824
32regulation of interferon-beta biosynthetic process (GO:0045357)3.20162442
33positive regulation of gamma-delta T cell activation (GO:0046645)3.18903276
34detection of other organism (GO:0098543)3.18308823
35detection of bacterium (GO:0016045)3.17164033
36positive regulation of type 2 immune response (GO:0002830)3.15769594
37NIK/NF-kappaB signaling (GO:0038061)3.05814505
38interferon-gamma secretion (GO:0072643)3.04486803
39positive regulation by symbiont of host defense response (GO:0052509)3.00445651
40modulation by symbiont of host defense response (GO:0052031)3.00445651
41modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.00445651
42modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.00445651
43positive regulation by organism of defense response of other organism involved in symbiotic interact3.00445651
44modulation by symbiont of host immune response (GO:0052553)3.00445651
45positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.00205704
46B cell mediated immunity (GO:0019724)2.98272266
47negative regulation of myeloid cell apoptotic process (GO:0033033)2.95770273
48regulation of mononuclear cell migration (GO:0071675)2.95507314
49positive regulation of interferon-beta production (GO:0032728)2.91723775
50positive regulation of chemokine biosynthetic process (GO:0045080)2.90975338
51regulation of type 2 immune response (GO:0002828)2.90395775
52negative regulation of type I interferon production (GO:0032480)2.88696997
53myeloid dendritic cell differentiation (GO:0043011)2.88137046
54lymphocyte chemotaxis (GO:0048247)2.86852806
55regulation of antigen processing and presentation (GO:0002577)2.85887322
56T cell migration (GO:0072678)2.85402025
57regulation of T-helper 1 cell differentiation (GO:0045625)2.85396428
58positive regulation of antigen processing and presentation (GO:0002579)2.82956048
59regulation of chemokine biosynthetic process (GO:0045073)2.81913965
60detection of external biotic stimulus (GO:0098581)2.81843824
61neutrophil activation involved in immune response (GO:0002283)2.80353650
62regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.78989628
63negative regulation of innate immune response (GO:0045824)2.78398878
64regulation of dendritic cell antigen processing and presentation (GO:0002604)2.77931584
65eosinophil chemotaxis (GO:0048245)2.74487285
66regulation of T cell tolerance induction (GO:0002664)2.73825869
67negative regulation of viral entry into host cell (GO:0046597)2.72216501
68response to host immune response (GO:0052572)2.66341823
69response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.66341823
70positive regulation of defense response to virus by host (GO:0002230)2.65849685
71response to protozoan (GO:0001562)2.65447850
72detection of molecule of bacterial origin (GO:0032490)2.64939666
73regulation of vitamin D biosynthetic process (GO:0060556)2.64795014
74negative regulation of multi-organism process (GO:0043901)2.62878468
75regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.62663207
76defense response to protozoan (GO:0042832)2.62449274
77negative regulation of production of molecular mediator of immune response (GO:0002701)2.61865823
78negative regulation of defense response to virus (GO:0050687)2.61738587
79positive regulation of T cell mediated cytotoxicity (GO:0001916)2.60296151
80regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.59711050
81regulation of T cell mediated cytotoxicity (GO:0001914)2.59097747
82amino sugar catabolic process (GO:0046348)2.58235000
83germinal center formation (GO:0002467)2.55185535
84regulation of defense response to virus by host (GO:0050691)2.54446877
85granulocyte activation (GO:0036230)2.53892708
86myeloid dendritic cell activation (GO:0001773)2.53404063
87regulation of viral entry into host cell (GO:0046596)2.52834502
88response to exogenous dsRNA (GO:0043330)2.52761938
89regulation of chronic inflammatory response (GO:0002676)2.51774257
90positive regulation of monocyte chemotaxis (GO:0090026)2.51620708
91regulation of RIG-I signaling pathway (GO:0039535)2.50055200
92T-helper 1 type immune response (GO:0042088)2.49871814
93positive regulation of lymphocyte migration (GO:2000403)2.47554809
94positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.47523381
95response to virus (GO:0009615)2.47162745
96regulation of lymphocyte migration (GO:2000401)2.46078998
97negative regulation of type 2 immune response (GO:0002829)2.46069683
98positive regulation of toll-like receptor signaling pathway (GO:0034123)2.45582241
99JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.45570182
100response to host defenses (GO:0052200)2.44895707

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.58060911
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.32732747
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.17334563
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.93526316
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.38407607
6* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.04829724
7RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.85024835
8IRF8_27001747_Chip-Seq_BMDM_Mouse2.59370509
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.40168440
10STAT4_19710469_ChIP-ChIP_TH1__Mouse2.38594548
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.33653062
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.29325282
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.12716357
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.09222179
15VDR_21846776_ChIP-Seq_THP-1_Human2.05136530
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.97797658
17LXR_22292898_ChIP-Seq_THP-1_Human1.95515829
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.92823734
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.92430428
20RARG_19884340_ChIP-ChIP_MEFs_Mouse1.89684222
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.89323556
22VDR_24763502_ChIP-Seq_THP-1_Human1.84860448
23ELK3_25401928_ChIP-Seq_HUVEC_Human1.81797630
24ESR2_21235772_ChIP-Seq_MCF-7_Human1.76629988
25MAF_26560356_Chip-Seq_TH1_Human1.71842841
26SMAD_19615063_ChIP-ChIP_OVARY_Human1.65836691
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.65822131
28MYB_21317192_ChIP-Seq_ERMYB_Mouse1.64138315
29TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.64125615
30TRIM28_21343339_ChIP-Seq_HEK293_Human1.57952969
31Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.56346461
32KDM2B_26808549_Chip-Seq_SUP-B15_Human1.55520920
33PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.55399483
34BRD4_27068464_Chip-Seq_AML-cells_Mouse1.55348246
35* RACK7_27058665_Chip-Seq_MCF-7_Human1.52959014
36NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.48629068
37* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.48599333
38EGR1_19374776_ChIP-ChIP_THP-1_Human1.47536735
39SPI1_23127762_ChIP-Seq_K562_Human1.45688405
40SPI1_23547873_ChIP-Seq_NB4_Human1.45411671
41RUNX1_22412390_ChIP-Seq_EML_Mouse1.44797665
42CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36450026
43* MAF_26560356_Chip-Seq_TH2_Human1.35751471
44ESR1_21235772_ChIP-Seq_MCF-7_Human1.32211230
45LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.28807639
46UTX_26944678_Chip-Seq_JUKART_Human1.28547398
47MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.26265795
48GATA1_22025678_ChIP-Seq_K562_Human1.25242252
49* KDM2B_26808549_Chip-Seq_DND41_Human1.25046360
50TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23485973
51* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.23449458
52LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.22878230
53PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21778367
54* MYB_26560356_Chip-Seq_TH2_Human1.20897910
55RXR_22158963_ChIP-Seq_LIVER_Mouse1.20877535
56CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18685768
57STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.17301901
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15646623
59PPARA_22158963_ChIP-Seq_LIVER_Mouse1.15365996
60TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.15302235
61STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.13991791
62GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.13822259
63TCF7_22412390_ChIP-Seq_EML_Mouse1.12995393
64VDR_24787735_ChIP-Seq_THP-1_Human1.12754163
65PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11606335
66BCL6_27268052_Chip-Seq_Bcells_Human1.10678515
67BCOR_27268052_Chip-Seq_Bcells_Human1.09107525
68SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08432108
69P63_26484246_Chip-Seq_KERATINOCYTES_Human1.08169087
70GATA2_21666600_ChIP-Seq_HMVEC_Human1.07440238
71* MYB_26560356_Chip-Seq_TH1_Human1.05177078
72VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03438040
73CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03240178
74GATA1_19941827_ChIP-Seq_MEL_Mouse1.01475935
75* SOX2_20726797_ChIP-Seq_SW620_Human1.01047714
76ELF1_20517297_ChIP-Seq_JURKAT_Human0.99348797
77TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.98890822
78FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.98248063
79ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.97821582
80RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.96595179
81SRY_22984422_ChIP-ChIP_TESTIS_Rat0.96295482
82MYC_22102868_ChIP-Seq_BL_Human0.96149341
83ZNF263_19887448_ChIP-Seq_K562_Human0.95740906
84SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.95643543
85TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95491280
86TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.95410799
87CTCF_27219007_Chip-Seq_ERYTHROID_Human0.95134630
88CTCF_26484167_Chip-Seq_Bcells_Mouse0.93879737
89CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.93460502
90TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93144734
91FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.92668105
92RUNX_20019798_ChIP-Seq_JUKART_Human0.92212621
93TFEB_21752829_ChIP-Seq_HELA_Human0.91596600
94PU.1_20513432_ChIP-Seq_Bcells_Mouse0.90930311
95SA1_27219007_Chip-Seq_ERYTHROID_Human0.90197706
96ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.90110472
97GATA2_22383799_ChIP-Seq_G1ME_Mouse0.89746561
98PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89724260
99SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89008112
100SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88960689

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.77587079
2MP0009785_altered_susceptibility_to3.71477820
3MP0006082_CNS_inflammation3.64485280
4MP0003724_increased_susceptibility_to3.55820046
5MP0003303_peritoneal_inflammation3.19988021
6MP0003436_decreased_susceptibility_to3.16081843
7MP0005058_abnormal_lysosome_morphology3.08164265
8MP0002148_abnormal_hypersensitivity_rea3.05633735
9MP0005025_abnormal_response_to2.79215207
10MP0003191_abnormal_cellular_cholesterol2.74141175
11MP0005671_abnormal_response_to2.72537942
12MP0005000_abnormal_immune_tolerance2.67002487
13MP0005387_immune_system_phenotype2.59182454
14MP0001790_abnormal_immune_system2.59182454
15MP0002419_abnormal_innate_immunity2.43832738
16MP0009840_abnormal_foam_cell2.42706576
17MP0004510_myositis2.29163225
18MP0000685_abnormal_immune_system2.24193279
19MP0002723_abnormal_immune_serum2.20896039
20MP0001800_abnormal_humoral_immune2.15624779
21MP0001533_abnormal_skeleton_physiology2.15397006
22MP0002452_abnormal_antigen_presenting2.10193299
23MP0003075_altered_response_to2.07375105
24MP0003300_gastrointestinal_ulcer2.05172442
25MP0000343_altered_response_to1.93647884
26MP0004947_skin_inflammation1.89336106
27MP0002420_abnormal_adaptive_immunity1.84494240
28MP0001819_abnormal_immune_cell1.84455484
29MP0000604_amyloidosis1.81733159
30MP0001845_abnormal_inflammatory_respons1.75914388
31MP0003172_abnormal_lysosome_physiology1.74719463
32MP0009333_abnormal_splenocyte_physiolog1.74213908
33MP0008469_abnormal_protein_level1.71010379
34MP0010155_abnormal_intestine_physiology1.69518155
35MP0005451_abnormal_body_composition1.65611281
36MP0009764_decreased_sensitivity_to1.61994521
37MP0002998_abnormal_bone_remodeling1.53027585
38MP0001853_heart_inflammation1.50775056
39MP0000858_altered_metastatic_potential1.47808784
40MP0003448_altered_tumor_morphology1.47106472
41MP0001542_abnormal_bone_strength1.46016404
42MP0002877_abnormal_melanocyte_morpholog1.44013152
43MP0002139_abnormal_hepatobiliary_system1.39944216
44MP0005166_decreased_susceptibility_to1.38463286
45MP0003806_abnormal_nucleotide_metabolis1.37917806
46MP0008438_abnormal_cutaneous_collagen1.36479677
47MP0002405_respiratory_system_inflammati1.36140682
48MP0000716_abnormal_immune_system1.31398662
49MP0005464_abnormal_platelet_physiology1.31046689
50MP0003183_abnormal_peptide_metabolism1.30150475
51MP0002933_joint_inflammation1.28409814
52MP0009278_abnormal_bone_marrow1.27441849
53MP0005310_abnormal_salivary_gland1.25284731
54MP0003329_amyloid_beta_deposits1.20900544
55MP0003763_abnormal_thymus_physiology1.20445747
56MP0003453_abnormal_keratinocyte_physiol1.19356718
57MP0005390_skeleton_phenotype1.11418829
58MP0008260_abnormal_autophagy1.10679805
59MP0005164_abnormal_response_to1.08944270
60MP0002398_abnormal_bone_marrow1.08914979
61MP0003045_fibrosis1.08814696
62MP0002166_altered_tumor_susceptibility1.08728211
63MP0005023_abnormal_wound_healing1.08645415
64MP0003690_abnormal_glial_cell1.05765778
65MP0009763_increased_sensitivity_to1.03632473
66MP0003279_aneurysm1.02470511
67MP0002254_reproductive_system_inflammat1.02185585
68MP0005165_increased_susceptibility_to1.01588755
69MP0002429_abnormal_blood_cell0.98546835
70MP0006054_spinal_hemorrhage0.96361193
71MP0004883_abnormal_blood_vessel0.96124574
72MP0001958_emphysema0.94158162
73MP0005397_hematopoietic_system_phenotyp0.93902066
74MP0001545_abnormal_hematopoietic_system0.93902066
75MP0002138_abnormal_hepatobiliary_system0.91561812
76MP0003705_abnormal_hypodermis_morpholog0.91057220
77MP0003866_abnormal_defecation0.89866334
78MP0003795_abnormal_bone_structure0.89248198
79MP0000689_abnormal_spleen_morphology0.88213352
80MP0002332_abnormal_exercise_endurance0.87466385
81MP0003091_abnormal_cell_migration0.86512853
82MP0002722_abnormal_immune_system0.83417014
83MP0002006_tumorigenesis0.80772673
84MP0001873_stomach_inflammation0.80211875
85MP0000920_abnormal_myelination0.79780970
86MP0008874_decreased_physiological_sensi0.77680610
87MP0005257_abnormal_intraocular_pressure0.73011162
88MP0001243_abnormal_dermal_layer0.71444195
89MP0004381_abnormal_hair_follicle0.67844402
90MP0005319_abnormal_enzyme/_coenzyme0.67810189
91MP0003186_abnormal_redox_activity0.67786199
92MP0000249_abnormal_blood_vessel0.66671254
93MP0010234_abnormal_vibrissa_follicle0.62637474
94MP0003195_calcinosis0.61072700
95MP0008004_abnormal_stomach_pH0.60140391
96MP0005167_abnormal_blood-brain_barrier0.60036347
97MP0001216_abnormal_epidermal_layer0.59900548
98MP0003879_abnormal_hair_cell0.58758903
99MP0009765_abnormal_xenobiotic_induced0.57426318
100MP0001348_abnormal_lacrimal_gland0.54667904

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)5.65101863
2Abnormality of glycosphingolipid metabolism (HP:0004343)5.65101863
3Abnormality of glycolipid metabolism (HP:0010969)5.65101863
4Abnormality of macrophages (HP:0004311)4.63648869
5Systemic lupus erythematosus (HP:0002725)4.24806433
6Eczematoid dermatitis (HP:0000976)4.12191578
7Orchitis (HP:0100796)3.93110310
8Myositis (HP:0100614)3.86386309
9Loss of speech (HP:0002371)3.85916130
10Recurrent bacterial skin infections (HP:0005406)3.85095114
11Recurrent abscess formation (HP:0002722)3.81879524
12Dysostosis multiplex (HP:0000943)3.81411430
13Vacuolated lymphocytes (HP:0001922)3.69342139
14Retrobulbar optic neuritis (HP:0100654)3.66322368
15Optic neuritis (HP:0100653)3.66322368
16Mediastinal lymphadenopathy (HP:0100721)3.40911259
17Elevated erythrocyte sedimentation rate (HP:0003565)3.33803553
18Increased cerebral lipofuscin (HP:0011813)3.24902514
19Abnormality of mucopolysaccharide metabolism (HP:0011020)3.16785431
20Abnormality of polysaccharide metabolism (HP:0011012)3.16785431
21Abnormality of glycosaminoglycan metabolism (HP:0004371)3.16785431
22Recurrent gram-negative bacterial infections (HP:0005420)3.16644162
23Urinary glycosaminoglycan excretion (HP:0003541)2.99465477
24Mucopolysacchariduria (HP:0008155)2.99465477
25Recurrent skin infections (HP:0001581)2.88794538
26Recurrent fungal infections (HP:0002841)2.86017390
27Chronic mucocutaneous candidiasis (HP:0002728)2.84852252
28Recurrent cutaneous fungal infections (HP:0011370)2.84852252
29Vertebral compression fractures (HP:0002953)2.83453031
30Vasculitis (HP:0002633)2.83177394
31Pulmonary infiltrates (HP:0002113)2.81857256
32Stomatitis (HP:0010280)2.80818266
33Progressive neurologic deterioration (HP:0002344)2.75545724
34Recurrent viral infections (HP:0004429)2.75221468
35Increased neuronal autofluorescent lipopigment (HP:0002074)2.73131856
36Hypergammaglobulinemia (HP:0010702)2.70047686
37Increased IgM level (HP:0003496)2.68869951
38Interstitial pulmonary disease (HP:0006530)2.67157224
39Gingivitis (HP:0000230)2.65377201
40Recurrent bronchitis (HP:0002837)2.64959098
41Obstructive lung disease (HP:0006536)2.62042714
42Chronic obstructive pulmonary disease (HP:0006510)2.62042714
43Meningitis (HP:0001287)2.59712331
44Hemoptysis (HP:0002105)2.58853336
45Purpura (HP:0000979)2.51004037
46Glomerulonephritis (HP:0000099)2.47961070
47Basal ganglia calcification (HP:0002135)2.43609237
48Abnormality of the nasal mucosa (HP:0000433)2.43199522
49Increased serum ferritin (HP:0003281)2.39801353
50Hepatosplenomegaly (HP:0001433)2.36799372
51Neurofibrillary tangles (HP:0002185)2.31673082
52Axonal loss (HP:0003447)2.31219697
53Autoimmune thrombocytopenia (HP:0001973)2.30686949
54Petechiae (HP:0000967)2.29586852
55T lymphocytopenia (HP:0005403)2.29192489
56Nasal polyposis (HP:0100582)2.28009747
57Abnormality of the pericardium (HP:0001697)2.27998847
58J-shaped sella turcica (HP:0002680)2.27713498
59Gastrointestinal infarctions (HP:0005244)2.25632800
60Keratoconjunctivitis sicca (HP:0001097)2.25556912
61Abnormality of T cell number (HP:0011839)2.23416016
62Complement deficiency (HP:0004431)2.21883680
63Amyloidosis (HP:0011034)2.21737134
64Emphysema (HP:0002097)2.20760255
65Cellulitis (HP:0100658)2.18334563
66Urticaria (HP:0001025)2.17801169
67Chronic otitis media (HP:0000389)2.17272991
68Abnormality of complement system (HP:0005339)2.16700081
69Prolonged neonatal jaundice (HP:0006579)2.16104183
70Increased IgE level (HP:0003212)2.14849069
71Nuclear cataract (HP:0100018)2.14044389
72Disinhibition (HP:0000734)2.11020669
73Cervical subluxation (HP:0003308)2.08774183
74Abnormal delayed hypersensitivity skin test (HP:0002963)2.03028396
75Arterial thrombosis (HP:0004420)2.02996360
76Bone pain (HP:0002653)2.02039030
77Keratoconjunctivitis (HP:0001096)2.01825094
78Gastrointestinal stroma tumor (HP:0100723)1.99478877
79Gangrene (HP:0100758)1.98663997
80Encephalitis (HP:0002383)1.97198908
81Autoimmune hemolytic anemia (HP:0001890)1.97130699
82Abnormality of iron homeostasis (HP:0011031)1.94969439
83Distal lower limb muscle weakness (HP:0009053)1.94189931
84Restrictive lung disease (HP:0002091)1.94114558
85Abnormality of the pleura (HP:0002103)1.92742496
86Cheilitis (HP:0100825)1.88085682
87Asymmetric septal hypertrophy (HP:0001670)1.86635981
88Cardiomegaly (HP:0001640)1.86321513
89Cerebral inclusion bodies (HP:0100314)1.84288519
90Arthralgia (HP:0002829)1.83309466
91Malnutrition (HP:0004395)1.83279070
92Joint swelling (HP:0001386)1.82970921
93Pulmonary embolism (HP:0002204)1.81431635
94Peritonitis (HP:0002586)1.81421082
95Premature loss of primary teeth (HP:0006323)1.80785256
96Nephritis (HP:0000123)1.80291758
97Glomerulopathy (HP:0100820)1.78111150
98Chest pain (HP:0100749)1.77760913
99Polyneuropathy (HP:0001271)1.76277979
100Pathologic fracture (HP:0002756)1.75909155

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TYK23.62732367
2ERN13.17222455
3TBK13.03890581
4IKBKE3.00865916
5IRAK32.78568785
6NME22.76453224
7FGFR42.67422286
8MAP4K12.51157621
9JAK32.47201328
10JAK12.40678713
11BLK2.32533563
12RIPK42.07403502
13KIT2.02572030
14TESK21.96981253
15IRAK41.94828523
16MAP3K111.90914752
17GRK71.89811982
18MAP3K141.85196530
19TRIB31.84991859
20RIPK11.84771868
21TESK11.80423844
22MAP3K31.75888237
23ZAP701.70027271
24CSK1.62652726
25PIM21.60774118
26TXK1.56602424
27IKBKB1.49912919
28TAOK21.49472396
29EPHB11.40497258
30SIK11.39731903
31PRPF4B1.39426412
32DDR21.34017741
33SMG11.32319153
34TAOK11.27227156
35EPHA21.25779558
36MAPKAPK31.25261400
37FGFR31.19574889
38MATK1.19144817
39MAP2K31.18050776
40TGFBR21.16475336
41TNK21.16368295
42CSF1R1.10348662
43JAK21.02377258
44SYK0.93884734
45CDC42BPA0.93294965
46MAP3K10.92808509
47LCK0.89420234
48HIPK20.86950721
49FES0.85969564
50LYN0.85120703
51MAPK110.84674539
52CHUK0.82770289
53SCYL20.82721219
54BTK0.80909282
55GRK60.78938522
56MOS0.78672999
57ABL20.78394381
58PAK40.78144039
59MAP3K130.78126668
60FGR0.77642842
61PRKD20.77065177
62ARAF0.74422348
63DAPK30.72198418
64KDR0.71630319
65BCKDK0.71243399
66LIMK10.70024439
67PKN20.64256502
68HCK0.63298600
69BMPR20.62736283
70FER0.59255197
71NEK90.59086236
72LRRK20.57177597
73ITK0.56345164
74PDPK10.55056075
75MAPK70.54344692
76ADRBK20.53070700
77MAP2K60.51484703
78BMX0.49413533
79EPHA30.48044573
80IRAK10.46552637
81PTK60.46399204
82PDK10.45624835
83PRKCD0.45178529
84RPS6KA20.42277496
85ABL10.41054571
86CAMK2G0.40743233
87MAPKAPK20.39961726
88MUSK0.39580842
89IRAK20.36277696
90STK100.34798648
91SIK30.33700703
92FYN0.33678398
93DAPK20.32763965
94MAP2K20.31633137
95TTN0.31392386
96RPS6KA50.30919285
97MAPK40.30836321
98PRKCQ0.30468849
99MARK30.29962299
100PRKD10.29929519

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053302.94398439
2Other glycan degradation_Homo sapiens_hsa005112.72396201
3Autoimmune thyroid disease_Homo sapiens_hsa053202.69527442
4Graft-versus-host disease_Homo sapiens_hsa053322.68117833
5Staphylococcus aureus infection_Homo sapiens_hsa051502.63690719
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.62138081
7RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.56808397
8Rheumatoid arthritis_Homo sapiens_hsa053232.39798913
9Leishmaniasis_Homo sapiens_hsa051402.37838294
10Osteoclast differentiation_Homo sapiens_hsa043802.37622398
11Measles_Homo sapiens_hsa051622.25260615
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.23933561
13Lysosome_Homo sapiens_hsa041422.17580816
14Influenza A_Homo sapiens_hsa051642.15067367
15Type I diabetes mellitus_Homo sapiens_hsa049402.10476309
16Antigen processing and presentation_Homo sapiens_hsa046122.09280641
17Asthma_Homo sapiens_hsa053102.07682158
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.99615378
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.97363676
20Glycosaminoglycan degradation_Homo sapiens_hsa005311.97297445
21Hepatitis C_Homo sapiens_hsa051601.90988836
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.89703752
23Primary immunodeficiency_Homo sapiens_hsa053401.87591286
24Herpes simplex infection_Homo sapiens_hsa051681.84880851
25Tuberculosis_Homo sapiens_hsa051521.81791142
26Malaria_Homo sapiens_hsa051441.81489498
27TNF signaling pathway_Homo sapiens_hsa046681.63572882
28Pertussis_Homo sapiens_hsa051331.60216963
29Viral myocarditis_Homo sapiens_hsa054161.51922760
30Phagosome_Homo sapiens_hsa041451.48815767
31Toxoplasmosis_Homo sapiens_hsa051451.42348061
32African trypanosomiasis_Homo sapiens_hsa051431.40240500
33NOD-like receptor signaling pathway_Homo sapiens_hsa046211.40017810
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.37816924
35Hematopoietic cell lineage_Homo sapiens_hsa046401.37438429
36Salmonella infection_Homo sapiens_hsa051321.33375453
37B cell receptor signaling pathway_Homo sapiens_hsa046621.30108837
38Legionellosis_Homo sapiens_hsa051341.29262925
39Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.27282646
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.23600261
41Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.14719801
42Jak-STAT signaling pathway_Homo sapiens_hsa046301.12607564
43Prion diseases_Homo sapiens_hsa050201.12455980
44Systemic lupus erythematosus_Homo sapiens_hsa053221.10121453
45Chemokine signaling pathway_Homo sapiens_hsa040621.09467640
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.06782588
47Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.06383441
48Hepatitis B_Homo sapiens_hsa051611.01385253
49Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.95847707
50Complement and coagulation cascades_Homo sapiens_hsa046100.92107627
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91775215
52Shigellosis_Homo sapiens_hsa051310.87489567
53Apoptosis_Homo sapiens_hsa042100.84527868
54Collecting duct acid secretion_Homo sapiens_hsa049660.83739478
55Acute myeloid leukemia_Homo sapiens_hsa052210.83270353
56Bladder cancer_Homo sapiens_hsa052190.79298796
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79278530
58T cell receptor signaling pathway_Homo sapiens_hsa046600.78636993
59Amoebiasis_Homo sapiens_hsa051460.74217864
60Vibrio cholerae infection_Homo sapiens_hsa051100.69403521
61Sulfur metabolism_Homo sapiens_hsa009200.68609372
62Prolactin signaling pathway_Homo sapiens_hsa049170.66365528
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64614449
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.63190893
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61131889
66Endocytosis_Homo sapiens_hsa041440.56781138
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.56220389
68Epstein-Barr virus infection_Homo sapiens_hsa051690.55626159
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55105936
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54585346
71Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54090047
72Sphingolipid metabolism_Homo sapiens_hsa006000.52553890
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.50887874
74Galactose metabolism_Homo sapiens_hsa000520.50293886
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49138854
76Viral carcinogenesis_Homo sapiens_hsa052030.48739652
77VEGF signaling pathway_Homo sapiens_hsa043700.46554130
78PPAR signaling pathway_Homo sapiens_hsa033200.42142845
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40661861
80Notch signaling pathway_Homo sapiens_hsa043300.39140808
81HTLV-I infection_Homo sapiens_hsa051660.38868308
82Fructose and mannose metabolism_Homo sapiens_hsa000510.38729463
83Pancreatic cancer_Homo sapiens_hsa052120.38011805
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.36733208
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35700936
86Mineral absorption_Homo sapiens_hsa049780.26713725
87Insulin resistance_Homo sapiens_hsa049310.25139080
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.20479494
89Chronic myeloid leukemia_Homo sapiens_hsa052200.19969468
90Platelet activation_Homo sapiens_hsa046110.19242107
91Proteoglycans in cancer_Homo sapiens_hsa052050.18026419
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.17159960
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.16348007
94Phenylalanine metabolism_Homo sapiens_hsa003600.16263379
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.16198492
96ABC transporters_Homo sapiens_hsa020100.15987692
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.15438270
98HIF-1 signaling pathway_Homo sapiens_hsa040660.14334275
99Type II diabetes mellitus_Homo sapiens_hsa049300.13921262
100Pentose phosphate pathway_Homo sapiens_hsa000300.13861757

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »