IFIT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing tetratricopeptide repeats that was originally identified as induced upon treatment with interferon. The encoded protein may inhibit viral replication and translational initiation. This gene is located in a cluster on chromosome 10 with five other closely related genes. There is a pseudogene for this gene on chromosome 13. Alternatively spliced transcript variants encoding multiple isoforms have been observed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to interferon-alpha (GO:0035457)6.67599284
2positive regulation of interferon-alpha production (GO:0032727)6.42804347
3* cellular response to type I interferon (GO:0071357)6.07029832
4* type I interferon signaling pathway (GO:0060337)6.07029832
5regulation of interferon-alpha production (GO:0032647)6.05590694
6* response to type I interferon (GO:0034340)6.01510601
7response to interferon-alpha (GO:0035455)5.95576192
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.81122294
9positive regulation by organism of defense response of other organism involved in symbiotic interact5.81122294
10modulation by symbiont of host immune response (GO:0052553)5.81122294
11positive regulation by symbiont of host defense response (GO:0052509)5.81122294
12modulation by symbiont of host defense response (GO:0052031)5.81122294
13modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.81122294
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.75345268
15response to peptidoglycan (GO:0032494)5.20168866
16cellular response to interferon-beta (GO:0035458)5.02658808
17* negative regulation of viral genome replication (GO:0045071)4.69005825
18regulation of T-helper 1 cell differentiation (GO:0045625)4.61913723
19neutrophil activation involved in immune response (GO:0002283)4.59828629
20positive regulation of interferon-beta production (GO:0032728)4.57170749
21response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.52216803
22response to host immune response (GO:0052572)4.52216803
23cellular response to virus (GO:0098586)4.48968093
24response to interferon-beta (GO:0035456)4.45399168
25immunoglobulin mediated immune response (GO:0016064)4.42153742
26regulation of RIG-I signaling pathway (GO:0039535)4.40611831
27lipopolysaccharide-mediated signaling pathway (GO:0031663)4.35480201
28positive regulation of type 2 immune response (GO:0002830)4.28621203
29* regulation of viral genome replication (GO:0045069)4.26967154
30positive regulation of chemokine biosynthetic process (GO:0045080)4.25099975
31negative regulation of interleukin-12 production (GO:0032695)4.23840656
32interferon-gamma-mediated signaling pathway (GO:0060333)4.17630630
33positive regulation of natural killer cell differentiation (GO:0032825)4.17606630
34T cell migration (GO:0072678)4.13522603
35regulation of type 2 immune response (GO:0002828)4.10441675
36natural killer cell activation involved in immune response (GO:0002323)4.07548226
37regulation of MHC class I biosynthetic process (GO:0045343)4.02219959
38positive regulation of cAMP-mediated signaling (GO:0043950)4.01756315
39macrophage activation involved in immune response (GO:0002281)4.00831187
40positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.00396051
41response to host defenses (GO:0052200)3.97165600
42response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.97165600
43response to host (GO:0075136)3.97165600
44negative regulation of type 2 immune response (GO:0002829)3.92598624
45regulation of interferon-beta biosynthetic process (GO:0045357)3.91359195
46positive regulation of toll-like receptor signaling pathway (GO:0034123)3.87153523
47lymphocyte chemotaxis (GO:0048247)3.84764309
48regulation of chemokine biosynthetic process (GO:0045073)3.80916308
49antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.78672308
50antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.78672308
51negative regulation of cell killing (GO:0031342)3.78002199
52negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.78002199
53natural killer cell mediated cytotoxicity (GO:0042267)3.77821637
54natural killer cell mediated immunity (GO:0002228)3.77821637
55eosinophil chemotaxis (GO:0048245)3.76801259
56positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.74464439
57positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.72999942
58hydrogen peroxide biosynthetic process (GO:0050665)3.72155186
59antigen processing and presentation of endogenous antigen (GO:0019883)3.71273787
60regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.67322681
61negative regulation of T cell mediated immunity (GO:0002710)3.65039697
62regulation of type I interferon-mediated signaling pathway (GO:0060338)3.61929741
63negative regulation of cytokine production involved in immune response (GO:0002719)3.60774058
64respiratory burst (GO:0045730)3.58103477
65positive regulation of gamma-delta T cell activation (GO:0046645)3.57093253
66microglial cell activation (GO:0001774)3.57014696
67defense response to protozoan (GO:0042832)3.54759070
68granulocyte activation (GO:0036230)3.51921989
69positive regulation of T cell cytokine production (GO:0002726)3.48957374
70positive regulation of interleukin-12 production (GO:0032735)3.47639687
71* defense response to virus (GO:0051607)3.47220633
72positive regulation of interleukin-17 production (GO:0032740)3.45498097
73regulation of activation of Janus kinase activity (GO:0010533)3.45246087
74cellular response to interferon-gamma (GO:0071346)3.41902173
75detection of other organism (GO:0098543)3.40637341
76superoxide anion generation (GO:0042554)3.40477384
77regulation of mononuclear cell migration (GO:0071675)3.39833055
78positive regulation of lymphocyte migration (GO:2000403)3.38448094
79B cell mediated immunity (GO:0019724)3.38432342
80negative regulation of type I interferon production (GO:0032480)3.37366439
81monocyte chemotaxis (GO:0002548)3.33769317
82positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.33445749
83regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.32421089
84eosinophil migration (GO:0072677)3.29933909
85regulation of interleukin-17 production (GO:0032660)3.29065518
86regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.27118323
87positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.27118323
88regulation of interferon-beta production (GO:0032648)3.26736495
89reactive oxygen species biosynthetic process (GO:1903409)3.25030548
90regulation of interferon-gamma biosynthetic process (GO:0045072)3.24986313
91neutrophil activation (GO:0042119)3.24673176
92response to muramyl dipeptide (GO:0032495)3.22151991
93detection of external biotic stimulus (GO:0098581)3.21649235
94* cellular response to exogenous dsRNA (GO:0071360)3.21037069
95detection of bacterium (GO:0016045)3.18772541
96T-helper 1 type immune response (GO:0042088)3.16762892
97positive regulation of monocyte chemotaxis (GO:0090026)3.15550726
98negative regulation of interleukin-17 production (GO:0032700)3.11930265
99regulation of toll-like receptor signaling pathway (GO:0034121)3.11153508
100myeloid cell activation involved in immune response (GO:0002275)3.10853399
101positive regulation of defense response to virus by host (GO:0002230)3.09439307
102positive regulation of heat generation (GO:0031652)3.08901523
103production of molecular mediator involved in inflammatory response (GO:0002532)3.08502396
104detection of molecule of bacterial origin (GO:0032490)3.08249402
105positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.07848849
106negative regulation of myeloid cell apoptotic process (GO:0033033)3.06528672
107positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.05255868
108response to interferon-gamma (GO:0034341)3.04295828
109* response to exogenous dsRNA (GO:0043330)3.04154992
110regulation of dendritic cell antigen processing and presentation (GO:0002604)3.02119485
111positive regulation of response to biotic stimulus (GO:0002833)2.99514673
112regulation of fever generation (GO:0031620)2.98116746
113response to protozoan (GO:0001562)2.97916938
114regulation of T-helper 2 cell differentiation (GO:0045628)2.96946218
115regulation of vitamin D biosynthetic process (GO:0060556)2.96755569
116regulation of lymphocyte chemotaxis (GO:1901623)2.96338929
117NIK/NF-kappaB signaling (GO:0038061)2.94925977
118* negative regulation of viral process (GO:0048525)2.94331380
119cellular response to zinc ion (GO:0071294)2.93835702
120positive regulation of antigen processing and presentation (GO:0002579)2.93446752
121interferon-gamma secretion (GO:0072643)2.92538591
122myeloid dendritic cell differentiation (GO:0043011)2.92457870
123germinal center formation (GO:0002467)2.91865987
124positive regulation of chemokine production (GO:0032722)2.91109019
125regulation of T cell tolerance induction (GO:0002664)2.90163925
126regulation of T cell cytokine production (GO:0002724)2.90151437
127negative regulation of production of molecular mediator of immune response (GO:0002701)2.89566303
128JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.88420926
129* response to virus (GO:0009615)2.87270137
130negative regulation of lymphocyte mediated immunity (GO:0002707)2.85515564
131macrophage activation (GO:0042116)2.82025370
132regulation of response to interferon-gamma (GO:0060330)2.77647037
133regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.75689863
134detection of biotic stimulus (GO:0009595)2.75299097
135negative regulation of viral entry into host cell (GO:0046597)2.74109920
136positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.73515824
137regulation of cytokine production involved in immune response (GO:0002718)2.71738285
138JAK-STAT cascade (GO:0007259)2.71237256

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human9.19914681
2IRF8_21731497_ChIP-ChIP_J774_Mouse7.63235205
3* IRF1_21803131_ChIP-Seq_MONOCYTES_Human6.78237045
4BP1_19119308_ChIP-ChIP_Hs578T_Human6.04290493
5* IRF8_22096565_ChIP-ChIP_GC-B_Mouse5.46958809
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.61188827
7IRF8_27001747_Chip-Seq_BMDM_Mouse4.14579585
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.39253754
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.27344683
10RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.17509021
11STAT4_19710469_ChIP-ChIP_TH1__Mouse2.99726697
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.94305640
13Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.80552129
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.64523355
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.38012299
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.36332578
17GATA1_22025678_ChIP-Seq_K562_Human2.32599208
18STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.32447111
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.04225590
20EGR1_19374776_ChIP-ChIP_THP-1_Human1.54473359
21SMAD_19615063_ChIP-ChIP_OVARY_Human1.53368048
22TP63_17297297_ChIP-ChIP_HaCaT_Human1.52127226
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.49118374
24EGR1_23403033_ChIP-Seq_LIVER_Mouse1.48188235
25CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.47612188
26CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.45058083
27MYB_26560356_Chip-Seq_TH2_Human1.44836794
28SPI1_23547873_ChIP-Seq_NB4_Human1.44616771
29PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.44552916
30PU_27001747_Chip-Seq_BMDM_Mouse1.42574911
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.42048601
32PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.38173652
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30869416
34BRD4_27068464_Chip-Seq_AML-cells_Mouse1.28618417
35EGR1_19032775_ChIP-ChIP_M12_Human1.27384847
36E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.26231919
37NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.25212311
38RUNX_20019798_ChIP-Seq_JUKART_Human1.23624940
39TRIM28_21343339_ChIP-Seq_HEK293_Human1.20567082
40VDR_24787735_ChIP-Seq_THP-1_Human1.19258043
41CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18170658
42MAF_26560356_Chip-Seq_TH1_Human1.15828985
43FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.15670234
44GATA3_26560356_Chip-Seq_TH2_Human1.15257405
45PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13545700
46VDR_21846776_ChIP-Seq_THP-1_Human1.13117357
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12587558
48KDM2B_26808549_Chip-Seq_SUP-B15_Human1.12127341
49CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11989459
50VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05627692
51GATA1_19941827_ChIP-Seq_MEL_Mouse1.04061436
52* MYB_26560356_Chip-Seq_TH1_Human1.01900515
53ESR2_21235772_ChIP-Seq_MCF-7_Human1.01141177
54* SOX2_20726797_ChIP-Seq_SW620_Human1.00834220
55CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00237335
56GATA2_21666600_ChIP-Seq_HMVEC_Human0.96905120
57RUNX1_22412390_ChIP-Seq_EML_Mouse0.96183106
58TCF7_22412390_ChIP-Seq_EML_Mouse0.95586498
59RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.94498278
60SPI1_23127762_ChIP-Seq_K562_Human0.93760671
61ELK3_25401928_ChIP-Seq_HUVEC_Human0.93403557
62GATA3_27048872_Chip-Seq_THYMUS_Human0.93126074
63STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.93111877
64KDM2B_26808549_Chip-Seq_DND41_Human0.92485828
65VDR_24763502_ChIP-Seq_THP-1_Human0.92200686
66PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91065436
67CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90830593
68NRF2_20460467_ChIP-Seq_MEFs_Mouse0.89819145
69NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.89819145
70FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.89706725
71RXR_22158963_ChIP-Seq_LIVER_Mouse0.88246621
72CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.87034261
73GATA2_22383799_ChIP-Seq_G1ME_Mouse0.86710601
74* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86044016
75* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.85821752
76RARG_19884340_ChIP-ChIP_MEFs_Mouse0.82296516
77SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81864693
78BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.81787331
79VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.81778258
80SCL_19346495_ChIP-Seq_HPC-7_Human0.81765423
81GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81363996
82LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.76511701
83LXR_22158963_ChIP-Seq_LIVER_Mouse0.76019080
84ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.75437072
85FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.74594583
86ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.73525550
87ESR1_21235772_ChIP-Seq_MCF-7_Human0.73226908
88GATA1_19941826_ChIP-Seq_K562_Human0.73092334
89NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.72846515
90RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.72801017
91KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.72435072
92GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71396423
93MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.71245733
94CJUN_26792858_Chip-Seq_BT549_Human0.70959230
95LXR_22292898_ChIP-Seq_THP-1_Human0.70526645
96IKZF1_21737484_ChIP-ChIP_HCT116_Human0.70100264
97CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.67548567
98P63_26484246_Chip-Seq_KERATINOCYTES_Human0.67430167
99GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.67256297
100BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.67200329
101PPARA_22158963_ChIP-Seq_LIVER_Mouse0.66894846
102* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.65897973
103JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.65520076
104STAT1_20625510_ChIP-Seq_HELA_Human0.65201132
105JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.65166596
106KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.64236407
107LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.64059544
108SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.62880176
109KDM2B_26808549_Chip-Seq_JURKAT_Human0.62346642
110SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.60104623
111PU1_27457419_Chip-Seq_LIVER_Mouse0.58250809
112TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.57403428
113STAT3_18555785_Chip-Seq_ESCs_Mouse0.57099452
114UTX_26944678_Chip-Seq_JUKART_Human0.55949347
115FLI1_27457419_Chip-Seq_LIVER_Mouse0.55908797
116SMRT_27268052_Chip-Seq_Bcells_Human0.55684387
117KAP1_22055183_ChIP-Seq_ESCs_Mouse0.55440589
118PU.1_20513432_ChIP-Seq_Bcells_Mouse0.54731134
119TP53_18474530_ChIP-ChIP_U2OS_Human0.54089272
120CMYC_18555785_Chip-Seq_ESCs_Mouse0.54021284
121SMAD1_18555785_Chip-Seq_ESCs_Mouse0.53668072
122SUZ12_18555785_Chip-Seq_ESCs_Mouse0.53154891
123PCGF2_27294783_Chip-Seq_ESCs_Mouse0.52316850
124ZFP57_27257070_Chip-Seq_ESCs_Mouse0.52097159
125NMYC_18555785_Chip-Seq_ESCs_Mouse0.51925883
126SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.51446205
127SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.51446205
128MAF_26560356_Chip-Seq_TH2_Human0.50451897
129RUNX1_27457419_Chip-Seq_LIVER_Mouse0.50427308

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009785_altered_susceptibility_to4.89296614
2MP0001835_abnormal_antigen_presentation4.78448940
3MP0003724_increased_susceptibility_to4.32900531
4MP0006082_CNS_inflammation4.32358815
5MP0002148_abnormal_hypersensitivity_rea4.00535916
6MP0003436_decreased_susceptibility_to3.72055384
7MP0005000_abnormal_immune_tolerance3.50496191
8MP0005025_abnormal_response_to3.41879601
9MP0001790_abnormal_immune_system3.08196190
10MP0005387_immune_system_phenotype3.08196190
11MP0005671_abnormal_response_to3.07763126
12MP0004510_myositis3.05816950
13MP0002419_abnormal_innate_immunity3.01864910
14MP0000685_abnormal_immune_system2.93797348
15MP0003303_peritoneal_inflammation2.75218238
16MP0002723_abnormal_immune_serum2.69961994
17MP0002452_abnormal_antigen_presenting2.63348940
18MP0001800_abnormal_humoral_immune2.62941555
19MP0009764_decreased_sensitivity_to2.45433444
20MP0001533_abnormal_skeleton_physiology2.25486450
21MP0001819_abnormal_immune_cell2.22816339
22MP0004947_skin_inflammation2.15993309
23MP0002420_abnormal_adaptive_immunity2.15959302
24MP0002006_tumorigenesis2.08191188
25MP0008469_abnormal_protein_level1.99129521
26MP0001853_heart_inflammation1.98400400
27MP0001845_abnormal_inflammatory_respons1.95299168
28MP0005058_abnormal_lysosome_morphology1.82377868
29MP0003448_altered_tumor_morphology1.81257731
30MP0010155_abnormal_intestine_physiology1.77310334
31MP0000343_altered_response_to1.75404098
32MP0002877_abnormal_melanocyte_morpholog1.74250984
33MP0005464_abnormal_platelet_physiology1.67281611
34MP0005451_abnormal_body_composition1.65203069
35MP0002405_respiratory_system_inflammati1.61602921
36MP0000716_abnormal_immune_system1.57516076
37MP0003075_altered_response_to1.56998451
38MP0002166_altered_tumor_susceptibility1.55873122
39MP0005310_abnormal_salivary_gland1.51225113
40MP0009333_abnormal_splenocyte_physiolog1.47327277
41MP0002398_abnormal_bone_marrow1.42487279
42MP0004782_abnormal_surfactant_physiolog1.40579739
43MP0002998_abnormal_bone_remodeling1.40091279
44MP0006054_spinal_hemorrhage1.38162860
45MP0003191_abnormal_cellular_cholesterol1.32415483
46MP0008004_abnormal_stomach_pH1.31139070
47MP0005167_abnormal_blood-brain_barrier1.30897867
48MP0002277_abnormal_respiratory_mucosa1.30496897
49MP0009278_abnormal_bone_marrow1.30005849
50MP0000858_altered_metastatic_potential1.28489211
51MP0005166_decreased_susceptibility_to1.25386258
52MP0005164_abnormal_response_to1.20971476
53MP0003186_abnormal_redox_activity1.19903017
54MP0002429_abnormal_blood_cell1.19691023
55MP0009763_increased_sensitivity_to1.16359520
56MP0009840_abnormal_foam_cell1.13863207
57MP0002139_abnormal_hepatobiliary_system1.12532851
58MP0000604_amyloidosis1.11717902
59MP0005397_hematopoietic_system_phenotyp1.10197296
60MP0001545_abnormal_hematopoietic_system1.10197296
61MP0005390_skeleton_phenotype1.06980103
62MP0003806_abnormal_nucleotide_metabolis1.06076270
63MP0003183_abnormal_peptide_metabolism1.05979828
64MP0001542_abnormal_bone_strength1.05351274
65MP0000689_abnormal_spleen_morphology1.04013791
66MP0003172_abnormal_lysosome_physiology1.03961477
67MP0002254_reproductive_system_inflammat1.03629011
68MP0003763_abnormal_thymus_physiology1.00431316
69MP0002722_abnormal_immune_system0.99261150
70MP0003690_abnormal_glial_cell0.98070678
71MP0003195_calcinosis0.96175216
72MP0002933_joint_inflammation0.95873188
73MP0004858_abnormal_nervous_system0.95743691
74MP0003221_abnormal_cardiomyocyte_apopto0.89764554
75MP0010307_abnormal_tumor_latency0.87042680
76MP0002138_abnormal_hepatobiliary_system0.85739999
77MP0008874_decreased_physiological_sensi0.84693217
78MP0003045_fibrosis0.83912326
79MP0003453_abnormal_keratinocyte_physiol0.82516620
80MP0010386_abnormal_urinary_bladder0.80416372
81MP0001851_eye_inflammation0.79313730
82MP0003252_abnormal_bile_duct0.77530074
83MP0003091_abnormal_cell_migration0.76818370
84MP0004808_abnormal_hematopoietic_stem0.76253909
85MP0008438_abnormal_cutaneous_collagen0.76210839
86MP0003879_abnormal_hair_cell0.74930299
87MP0003656_abnormal_erythrocyte_physiolo0.74085183
88MP0000249_abnormal_blood_vessel0.70814334
89MP0000465_gastrointestinal_hemorrhage0.70581277
90MP0003866_abnormal_defecation0.69096495
91MP0003705_abnormal_hypodermis_morpholog0.67894759
92MP0003300_gastrointestinal_ulcer0.67096803
93MP0003136_yellow_coat_color0.66377574
94MP0002136_abnormal_kidney_physiology0.65665837
95MP0003279_aneurysm0.63651623
96MP0002332_abnormal_exercise_endurance0.61169172
97MP0003828_pulmonary_edema0.58863725
98MP0009765_abnormal_xenobiotic_induced0.57971372
99MP0000372_irregular_coat_pigmentation0.57038256
100MP0008260_abnormal_autophagy0.55239214
101MP0001958_emphysema0.55099299
102MP0003329_amyloid_beta_deposits0.54927985
103MP0003795_abnormal_bone_structure0.53874643
104MP0002693_abnormal_pancreas_physiology0.53573842
105MP0005023_abnormal_wound_healing0.53034995
106MP0004883_abnormal_blood_vessel0.52346154
107MP0001881_abnormal_mammary_gland0.52060067
108MP0002090_abnormal_vision0.50195067
109MP0003566_abnormal_cell_adhesion0.49985420
110MP0000920_abnormal_myelination0.48349221
111MP0001348_abnormal_lacrimal_gland0.47272111
112MP0000767_abnormal_smooth_muscle0.46517687
113MP0005165_increased_susceptibility_to0.46276825
114MP0005319_abnormal_enzyme/_coenzyme0.45915463
115MP0001346_abnormal_lacrimal_gland0.45571284
116MP0001873_stomach_inflammation0.45216535
117MP0002168_other_aberrant_phenotype0.44800747
118MP0001663_abnormal_digestive_system0.44582032
119MP0001501_abnormal_sleep_pattern0.44565617

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)7.01442555
2Recurrent abscess formation (HP:0002722)6.48168564
3Recurrent bacterial skin infections (HP:0005406)6.18121044
4Elevated erythrocyte sedimentation rate (HP:0003565)5.82624954
5Increased IgM level (HP:0003496)5.69792524
6Autoimmune thrombocytopenia (HP:0001973)5.62983122
7Recurrent gram-negative bacterial infections (HP:0005420)5.57116410
8Abnormality of macrophages (HP:0004311)4.94218850
9Basal ganglia calcification (HP:0002135)4.71732784
10Mediastinal lymphadenopathy (HP:0100721)4.71233892
11Stomatitis (HP:0010280)4.36072785
12Systemic lupus erythematosus (HP:0002725)4.30939180
13Recurrent skin infections (HP:0001581)4.29001132
14Vasculitis (HP:0002633)4.27455975
15Recurrent fungal infections (HP:0002841)4.01964462
16Myositis (HP:0100614)3.87334765
17Hypergammaglobulinemia (HP:0010702)3.87280861
18Orchitis (HP:0100796)3.82348439
19Gingivitis (HP:0000230)3.79548405
20Recurrent cutaneous fungal infections (HP:0011370)3.78945832
21Chronic mucocutaneous candidiasis (HP:0002728)3.78945832
22Autoimmune hemolytic anemia (HP:0001890)3.75007901
23Porencephaly (HP:0002132)3.69414753
24Loss of speech (HP:0002371)3.64807673
25Interstitial pulmonary disease (HP:0006530)3.64566830
26Optic neuritis (HP:0100653)3.59666295
27Retrobulbar optic neuritis (HP:0100654)3.59666295
28Keratoconjunctivitis (HP:0001096)3.55411260
29Recurrent viral infections (HP:0004429)3.54006474
30Obstructive lung disease (HP:0006536)3.46628937
31Chronic obstructive pulmonary disease (HP:0006510)3.46628937
32Chronic otitis media (HP:0000389)3.43262975
33Vacuolated lymphocytes (HP:0001922)3.42799829
34Prostate neoplasm (HP:0100787)3.42232193
35Tetraparesis (HP:0002273)3.24479621
36Pustule (HP:0200039)3.17113684
37Peritonitis (HP:0002586)3.07552765
38Abnormal delayed hypersensitivity skin test (HP:0002963)3.04862549
39Increased neuronal autofluorescent lipopigment (HP:0002074)2.92757101
40Recurrent bronchitis (HP:0002837)2.92734906
41Thick nail (HP:0001805)2.91589800
42Periodontitis (HP:0000704)2.90867584
43Recurrent pneumonia (HP:0006532)2.89442299
44Increased cerebral lipofuscin (HP:0011813)2.85834886
45Poor head control (HP:0002421)2.84249254
46Pulmonary infiltrates (HP:0002113)2.83356825
47Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.78552102
48Urticaria (HP:0001025)2.73651448
49Recurrent lower respiratory tract infections (HP:0002783)2.70423960
50Axonal loss (HP:0003447)2.65658681
51Gingival bleeding (HP:0000225)2.64119314
52Petechiae (HP:0000967)2.63254318
53Dysostosis multiplex (HP:0000943)2.62326414
54Abnormality of T cell number (HP:0011839)2.62310338
55Encephalitis (HP:0002383)2.59897853
56Gangrene (HP:0100758)2.59896779
57Purpura (HP:0000979)2.58133903
58Abnormality of the endocardium (HP:0004306)2.56870960
59Cleft eyelid (HP:0000625)2.56384808
60Alveolar cell carcinoma (HP:0006519)2.56260650
61Leukocytosis (HP:0001974)2.56063138
62Amyloidosis (HP:0011034)2.55263494
63Joint swelling (HP:0001386)2.53051499
64Progressive neurologic deterioration (HP:0002344)2.52858285
65Gastrointestinal infarctions (HP:0005244)2.50233593
66Cellulitis (HP:0100658)2.49791242
67Hemoptysis (HP:0002105)2.49392020
68Neoplasm of the tracheobronchial system (HP:0100552)2.47095102
69Prolonged neonatal jaundice (HP:0006579)2.45472198
70Nasal polyposis (HP:0100582)2.42656422
71Joint hemorrhage (HP:0005261)2.38131547
72Abnormality of T cell physiology (HP:0011840)2.36562409
73Abnormality of T cells (HP:0002843)2.35856287
74Premature loss of primary teeth (HP:0006323)2.35772455
75Meningitis (HP:0001287)2.34127186
76Hepatosplenomegaly (HP:0001433)2.33417365
77Increased serum ferritin (HP:0003281)2.33103644
78Chest pain (HP:0100749)2.32104216
79IgA deficiency (HP:0002720)2.31181352
80Abnormality of the nasal mucosa (HP:0000433)2.30415889
81Pulmonary embolism (HP:0002204)2.29142679
82Spontaneous hematomas (HP:0007420)2.28788893
83Myocardial infarction (HP:0001658)2.28354952
84Abnormality of the pericardium (HP:0001697)2.28109024
85Arterial thrombosis (HP:0004420)2.25369422
86Osteolytic defects of the phalanges of the hand (HP:0009771)2.23419713
87Osteolytic defects of the hand bones (HP:0009699)2.23419713
88Episodic fever (HP:0001954)2.23376848
89Eosinophilia (HP:0001880)2.22995912
90IgG deficiency (HP:0004315)2.22178786
91Nephritis (HP:0000123)2.21970456
92Cheilitis (HP:0100825)2.17259410
93Anorexia (HP:0002039)2.17094708
94T lymphocytopenia (HP:0005403)2.16895961
95Disinhibition (HP:0000734)2.15193502
96Vertebral compression fractures (HP:0002953)2.14239975
97Osteomyelitis (HP:0002754)2.13113751
98Abnormality of the prostate (HP:0008775)2.12390494
99Bone pain (HP:0002653)2.12171280
100Glomerulonephritis (HP:0000099)2.11896943
101Increased IgE level (HP:0003212)2.11869085
102Progressive visual loss (HP:0000529)2.11019964
103Arthralgia (HP:0002829)2.09983894
104Hemorrhage of the eye (HP:0011885)2.09153777
105Abnormality of the basal ganglia (HP:0002134)2.08974671
106Abnormality of eosinophils (HP:0001879)2.07919478
107Abnormality of polysaccharide metabolism (HP:0011012)2.07700520
108Abnormality of glycosaminoglycan metabolism (HP:0004371)2.07700520
109Abnormality of mucopolysaccharide metabolism (HP:0011020)2.07700520
110Lower limb hyperreflexia (HP:0002395)2.06583355
111Emphysema (HP:0002097)2.06483602
112Abnormality of iron homeostasis (HP:0011031)2.05768031
113Hematochezia (HP:0002573)2.05754587
114Vertigo (HP:0002321)2.05482080
115Glomerulopathy (HP:0100820)2.04059945
116Skin ulcer (HP:0200042)2.03169930
117Chronic sinusitis (HP:0011109)2.03067976
118Polyneuropathy (HP:0001271)2.02148165
119Abnormality of glycolipid metabolism (HP:0010969)2.01681100
120Abnormality of liposaccharide metabolism (HP:0010968)2.01681100
121Abnormality of glycosphingolipid metabolism (HP:0004343)2.01681100
122Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.01252131
123Parakeratosis (HP:0001036)2.00576285
124Chronic diarrhea (HP:0002028)1.99672193
125Neurofibrillary tangles (HP:0002185)1.99617113
126Mucopolysacchariduria (HP:0008155)1.98873632
127Urinary glycosaminoglycan excretion (HP:0003541)1.98873632
128Keratoconjunctivitis sicca (HP:0001097)1.98468268
129Abnormality of the pleura (HP:0002103)1.96602302
130Keratitis (HP:0000491)1.96251705
131Abnormality of cells of the lymphoid lineage (HP:0012140)1.95725323
132Apathy (HP:0000741)1.95188332
133Acne (HP:0001061)1.94753861
134Pigmentary retinal degeneration (HP:0001146)1.94228318
135Hypochromic microcytic anemia (HP:0004840)1.91692501
136Abnormality of the peritoneum (HP:0002585)1.89702987
137Diminished motivation (HP:0000745)1.86511904
138Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.83481053

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK5.14090029
2MAP3K144.49263710
3TBK14.20413290
4TYK23.99175201
5IKBKE3.97327007
6IRAK43.27477340
7BLK3.26970445
8JAK33.03718902
9RIPK42.99610449
10TXK2.75520768
11JAK12.72342798
12FGFR42.58522862
13IRAK32.37622237
14KIT2.35251372
15IKBKB2.33548493
16PIM22.28917153
17MAP3K132.03140853
18MAP2K31.91811262
19PRPF4B1.79016035
20MST41.75826029
21MAP3K31.75578803
22TAOK21.67616751
23MAP4K11.64149058
24CSK1.57123672
25BMPR21.55423914
26FGFR31.51442663
27ERN11.45745562
28TAOK11.40158904
29IRAK11.38924004
30CHUK1.36620907
31EPHA31.34005402
32ZAP701.33734666
33EIF2AK21.31695046
34MAP3K111.31678621
35EPHB11.26606953
36SYK1.24508784
37NEK91.21708436
38MATK1.17097349
39HCK1.15593566
40FGR1.07603667
41IRAK21.06326949
42MAP3K51.03943123
43BMX1.03147715
44LCK1.00571550
45RPS6KA40.98317184
46ABL20.97483872
47CDC42BPA0.96360248
48LYN0.94979941
49MST1R0.91251347
50TNK20.88932732
51JAK20.88374853
52STK40.87212668
53ARAF0.86026992
54PIM10.85342725
55NME20.78942116
56SIK30.77770642
57ADRBK20.77273951
58RIPK10.74614768
59ERBB30.71486757
60MARK30.70498841
61TAOK30.69542560
62TRPM70.69328451
63BTK0.67598229
64HIPK20.66565552
65STK240.66137456
66PRKCD0.66061631
67PRKD20.63719909
68TAF10.62020355
69GRK70.59234689
70ABL10.58822599
71MAP3K60.57793853
72MAP3K120.56959041
73TEC0.56156375
74EGFR0.52944029
75DAPK30.51130188
76MAPK70.50727838
77PRKCQ0.49477631
78PIK3CG0.48710095
79CSF1R0.47633530
80RPS6KA50.47507177
81TESK10.47407367
82BCR0.46298210
83SIK10.45175209
84NLK0.44890858
85TRIB30.42098397
86TGFBR20.41309298
87FES0.39242894
88STK30.39101083
89YES10.38124232
90MAP2K60.37446858
91KSR20.37169924
92ERBB40.35206017
93TTN0.34564434
94BMPR1B0.34472690
95KDR0.32561459
96SIK20.32554736
97MOS0.31817254
98GRK60.30549963
99DAPK20.28718448
100STK100.28378749
101MAP3K10.28209335
102MAPK110.27351375
103PDGFRA0.25588840
104FYN0.25383618
105MARK20.25351649
106TESK20.24648231
107LATS20.23281985
108PDGFRB0.22537820
109PRKCI0.22399131
110PKN10.22256946
111MELK0.21254217
112INSR0.21142098
113STK380.21015195
114IGF1R0.20093072
115SGK30.19752964
116NUAK10.19438986
117DYRK1B0.18505847
118MAPKAPK20.17719394
119PTK2B0.17591525
120PLK20.17513089
121CAMKK20.16768898
122ITK0.16651841
123SRC0.15765200
124PDK10.14360166
125PRKCE0.13575962
126DDR20.11539240
127CLK10.10757714
128PRKG20.10427098
129PDPK10.09757197
130CAMK1D0.08594201
131MAPK40.06716538
132RPS6KA10.04477610
133MAPK30.04246864
134PRKCH0.02741940

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.95575914
2Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.69483426
3Allograft rejection_Homo sapiens_hsa053303.40679514
4Toll-like receptor signaling pathway_Homo sapiens_hsa046203.34881031
5RIG-I-like receptor signaling pathway_Homo sapiens_hsa046223.10841523
6Leishmaniasis_Homo sapiens_hsa051403.10315204
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.75937835
8Staphylococcus aureus infection_Homo sapiens_hsa051502.62997723
9Measles_Homo sapiens_hsa051622.54863672
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.42612465
11Malaria_Homo sapiens_hsa051442.39906697
12Type I diabetes mellitus_Homo sapiens_hsa049402.37719505
13Asthma_Homo sapiens_hsa053102.37105230
14Influenza A_Homo sapiens_hsa051642.32494327
15Rheumatoid arthritis_Homo sapiens_hsa053232.31969320
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.31805115
17Legionellosis_Homo sapiens_hsa051342.29446740
18NOD-like receptor signaling pathway_Homo sapiens_hsa046212.26218391
19Pertussis_Homo sapiens_hsa051332.11229702
20TNF signaling pathway_Homo sapiens_hsa046682.01546783
21African trypanosomiasis_Homo sapiens_hsa051431.95566273
22Osteoclast differentiation_Homo sapiens_hsa043801.95249026
23* Herpes simplex infection_Homo sapiens_hsa051681.93395008
24Tuberculosis_Homo sapiens_hsa051521.92722493
25Autoimmune thyroid disease_Homo sapiens_hsa053201.81733074
26Salmonella infection_Homo sapiens_hsa051321.72849931
27Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.66416158
28Toxoplasmosis_Homo sapiens_hsa051451.50903122
29Primary immunodeficiency_Homo sapiens_hsa053401.50615325
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.42667635
31Chemokine signaling pathway_Homo sapiens_hsa040621.39248959
32Antigen processing and presentation_Homo sapiens_hsa046121.35408267
33Phagosome_Homo sapiens_hsa041451.34501696
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.34408700
35Hematopoietic cell lineage_Homo sapiens_hsa046401.31731506
36Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.31649420
37Viral myocarditis_Homo sapiens_hsa054161.24951128
38* Hepatitis C_Homo sapiens_hsa051601.19001555
39Lysosome_Homo sapiens_hsa041421.17914062
40Apoptosis_Homo sapiens_hsa042101.14641427
41Hepatitis B_Homo sapiens_hsa051611.11557808
42Shigellosis_Homo sapiens_hsa051311.01082974
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89108494
44Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88029630
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86355969
46B cell receptor signaling pathway_Homo sapiens_hsa046620.85954561
47Amoebiasis_Homo sapiens_hsa051460.80975838
48Prion diseases_Homo sapiens_hsa050200.79764271
49Caffeine metabolism_Homo sapiens_hsa002320.71060462
50T cell receptor signaling pathway_Homo sapiens_hsa046600.70146008
51SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66331293
52Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.62507826
53Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61907205
54Prolactin signaling pathway_Homo sapiens_hsa049170.61830695
55Complement and coagulation cascades_Homo sapiens_hsa046100.61581691
56Bladder cancer_Homo sapiens_hsa052190.59356641
57Proteasome_Homo sapiens_hsa030500.58813033
58Other glycan degradation_Homo sapiens_hsa005110.57601297
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57581613
60Glycosaminoglycan degradation_Homo sapiens_hsa005310.53493691
61Leukocyte transendothelial migration_Homo sapiens_hsa046700.53069134
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.50117097
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47257802
64VEGF signaling pathway_Homo sapiens_hsa043700.46356833
65Collecting duct acid secretion_Homo sapiens_hsa049660.45827689
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45079590
67Epstein-Barr virus infection_Homo sapiens_hsa051690.44414745
68Mineral absorption_Homo sapiens_hsa049780.43422252
69Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42634192
70Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42145576
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41206089
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.35304433
73FoxO signaling pathway_Homo sapiens_hsa040680.33934794
74Insulin resistance_Homo sapiens_hsa049310.32342168
75Sulfur metabolism_Homo sapiens_hsa009200.31992624
76HIF-1 signaling pathway_Homo sapiens_hsa040660.29690170
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29503067
78Viral carcinogenesis_Homo sapiens_hsa052030.29132613
79Platelet activation_Homo sapiens_hsa046110.28345021
80Notch signaling pathway_Homo sapiens_hsa043300.26432586
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.25668341
82Acute myeloid leukemia_Homo sapiens_hsa052210.25475126
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.24927819
84Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.24357301
85Pancreatic cancer_Homo sapiens_hsa052120.23142934
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.21256819
87Renal cell carcinoma_Homo sapiens_hsa052110.21250817
88Type II diabetes mellitus_Homo sapiens_hsa049300.20866768
89Small cell lung cancer_Homo sapiens_hsa052220.20138196
90GnRH signaling pathway_Homo sapiens_hsa049120.20100890
91Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.19644743
92mTOR signaling pathway_Homo sapiens_hsa041500.19608151
93Galactose metabolism_Homo sapiens_hsa000520.19056319
94Non-small cell lung cancer_Homo sapiens_hsa052230.18613479
95PPAR signaling pathway_Homo sapiens_hsa033200.17956635
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.17584518
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.17009908
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.16159886
99Steroid biosynthesis_Homo sapiens_hsa001000.14235433
100Dorso-ventral axis formation_Homo sapiens_hsa043200.13202764
101Chronic myeloid leukemia_Homo sapiens_hsa052200.13123887
102Sphingolipid metabolism_Homo sapiens_hsa006000.13022446
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.12883663
104HTLV-I infection_Homo sapiens_hsa051660.11604825
105Proteoglycans in cancer_Homo sapiens_hsa052050.08421403
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.08204645
107Primary bile acid biosynthesis_Homo sapiens_hsa001200.08025806
108Systemic lupus erythematosus_Homo sapiens_hsa053220.06267276
109Vibrio cholerae infection_Homo sapiens_hsa051100.02606097
110Renin-angiotensin system_Homo sapiens_hsa046140.02333638
111Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.02330828
112p53 signaling pathway_Homo sapiens_hsa041150.00102352
113Endocytosis_Homo sapiens_hsa04144-0.0071363
114ABC transporters_Homo sapiens_hsa02010-0.0059876
115MAPK signaling pathway_Homo sapiens_hsa04010-0.0055928

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