IFIT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of interferon-alpha production (GO:0032727)6.55789382
2modulation by symbiont of host defense response (GO:0052031)6.35583271
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.35583271
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.35583271
5positive regulation by organism of defense response of other organism involved in symbiotic interact6.35583271
6modulation by symbiont of host immune response (GO:0052553)6.35583271
7positive regulation by symbiont of host defense response (GO:0052509)6.35583271
8regulation of interferon-alpha production (GO:0032647)6.18414486
9* type I interferon signaling pathway (GO:0060337)6.05181698
10* cellular response to type I interferon (GO:0071357)6.05181698
11* response to type I interferon (GO:0034340)5.99787546
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.67375520
13negative regulation of viral genome replication (GO:0045071)5.38585234
14positive regulation of type 2 immune response (GO:0002830)5.00491686
15response to peptidoglycan (GO:0032494)4.92216866
16* response to interferon-alpha (GO:0035455)4.91962666
17cellular response to exogenous dsRNA (GO:0071360)4.91401621
18negative regulation of interleukin-12 production (GO:0032695)4.78749734
19response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.75427433
20response to host immune response (GO:0052572)4.75427433
21regulation of interferon-beta biosynthetic process (GO:0045357)4.73143312
22neutrophil activation involved in immune response (GO:0002283)4.72970442
23regulation of T-helper 1 cell differentiation (GO:0045625)4.72753861
24positive regulation of natural killer cell differentiation (GO:0032825)4.68393263
25positive regulation of interferon-beta production (GO:0032728)4.62697546
26positive regulation of interferon-gamma biosynthetic process (GO:0045078)4.59949738
27antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.56364913
28antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.56364913
29positive regulation of gamma-delta T cell activation (GO:0046645)4.51641930
30regulation of RIG-I signaling pathway (GO:0039535)4.43621660
31natural killer cell mediated immunity (GO:0002228)4.42989467
32natural killer cell mediated cytotoxicity (GO:0042267)4.42989467
33cellular response to interferon-beta (GO:0035458)4.41308813
34cellular response to virus (GO:0098586)4.40401416
35macrophage activation involved in immune response (GO:0002281)4.40050128
36immunoglobulin mediated immune response (GO:0016064)4.37869068
37antigen processing and presentation of endogenous antigen (GO:0019883)4.36356807
38positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.31838200
39positive regulation of T cell cytokine production (GO:0002726)4.23938968
40response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.21663194
41response to host (GO:0075136)4.21663194
42response to host defenses (GO:0052200)4.21663194
43lipopolysaccharide-mediated signaling pathway (GO:0031663)4.21555212
44negative regulation of cell killing (GO:0031342)4.20388761
45negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.20388761
46interferon-gamma-mediated signaling pathway (GO:0060333)4.14366200
47detection of molecule of bacterial origin (GO:0032490)4.13381046
48T-helper 1 type immune response (GO:0042088)4.10162029
49positive regulation of toll-like receptor signaling pathway (GO:0034123)4.04802584
50response to interferon-beta (GO:0035456)4.04264367
51T cell migration (GO:0072678)4.02790313
52regulation of type 2 immune response (GO:0002828)3.96645495
53lymphocyte chemotaxis (GO:0048247)3.91231245
54negative regulation of T cell mediated immunity (GO:0002710)3.90302254
55regulation of interferon-gamma biosynthetic process (GO:0045072)3.89255288
56positive regulation of cAMP-mediated signaling (GO:0043950)3.87460374
57microglial cell activation (GO:0001774)3.81921098
58positive regulation of chemokine biosynthetic process (GO:0045080)3.80513894
59regulation of MHC class I biosynthetic process (GO:0045343)3.77460632
60granulocyte activation (GO:0036230)3.74628679
61regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.73701541
62positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.70550574
63detection of other organism (GO:0098543)3.63393507
64positive regulation of interleukin-12 production (GO:0032735)3.61942436
65negative regulation of type 2 immune response (GO:0002829)3.60933874
66hydrogen peroxide biosynthetic process (GO:0050665)3.59934391
67negative regulation of cytokine production involved in immune response (GO:0002719)3.59762017
68regulation of type I interferon-mediated signaling pathway (GO:0060338)3.59693461
69* defense response to virus (GO:0051607)3.59493055
70regulation of activation of Janus kinase activity (GO:0010533)3.59320397
71* cellular response to interferon-alpha (GO:0035457)3.58608426
72cellular response to interferon-gamma (GO:0071346)3.51875585
73positive regulation of interleukin-17 production (GO:0032740)3.50382562
74positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.50206698
75regulation of dendritic cell antigen processing and presentation (GO:0002604)3.48687358
76neutrophil activation (GO:0042119)3.47962257
77respiratory burst (GO:0045730)3.46320053
78natural killer cell activation involved in immune response (GO:0002323)3.44655024
79regulation of mononuclear cell migration (GO:0071675)3.44240774
80detection of external biotic stimulus (GO:0098581)3.41117094
81positive regulation of antigen processing and presentation (GO:0002579)3.40650944
82B cell mediated immunity (GO:0019724)3.40185729
83regulation of chemokine biosynthetic process (GO:0045073)3.39381979
84defense response to protozoan (GO:0042832)3.37591717
85regulation of interferon-beta production (GO:0032648)3.33965184
86myeloid cell activation involved in immune response (GO:0002275)3.30973062
87regulation of defense response to virus by host (GO:0050691)3.29885611
88monocyte chemotaxis (GO:0002548)3.27239185
89eosinophil chemotaxis (GO:0048245)3.26836995
90detection of bacterium (GO:0016045)3.26080056
91cellular response to zinc ion (GO:0071294)3.25464254
92positive regulation of lymphocyte migration (GO:2000403)3.25294390
93response to exogenous dsRNA (GO:0043330)3.24320345
94regulation of interleukin-17 production (GO:0032660)3.21561333
95regulation of vitamin D biosynthetic process (GO:0060556)3.21081614
96negative regulation of viral process (GO:0048525)3.20491513
97response to interferon-gamma (GO:0034341)3.19728081
98regulation of viral genome replication (GO:0045069)3.17511708
99reactive oxygen species biosynthetic process (GO:1903409)3.16657413
100negative regulation of interleukin-17 production (GO:0032700)3.16467902
101regulation of gamma-delta T cell activation (GO:0046643)3.15426124
102negative regulation of myeloid cell apoptotic process (GO:0033033)3.13533322
103positive regulation of response to biotic stimulus (GO:0002833)3.13413144
104negative regulation of lymphocyte mediated immunity (GO:0002707)3.10665059
105regulation of T cell tolerance induction (GO:0002664)3.10303481
106response to muramyl dipeptide (GO:0032495)3.10244209
107positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.09370045
108germinal center formation (GO:0002467)3.08520434
109JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.07992312
110regulation of T cell cytokine production (GO:0002724)3.07912932
111regulation of toll-like receptor signaling pathway (GO:0034121)3.07751460
112leukocyte mediated cytotoxicity (GO:0001909)3.06878694
113regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.04845982
114macrophage activation (GO:0042116)3.04740716
115myeloid dendritic cell differentiation (GO:0043011)3.03598548
116positive regulation of heat generation (GO:0031652)3.03587648
117regulation of chronic inflammatory response (GO:0002676)3.03317301
118regulation of immunoglobulin secretion (GO:0051023)3.02863070
119response to protozoan (GO:0001562)3.01546946
120detection of biotic stimulus (GO:0009595)3.00459535
121positive regulation of monocyte chemotaxis (GO:0090026)2.99979999
122regulation of T-helper 2 cell differentiation (GO:0045628)2.99977376
123NIK/NF-kappaB signaling (GO:0038061)2.99501974
124interferon-gamma secretion (GO:0072643)2.98987724
125I-kappaB phosphorylation (GO:0007252)2.98486214
126regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.97515432
127positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.97515432
128positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.96688708
129negative regulation of type I interferon production (GO:0032480)2.95800150
130regulation of natural killer cell differentiation (GO:0032823)2.95752247
131regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.95570236
132regulation of antigen processing and presentation (GO:0002577)2.94401743
133regulation of interleukin-12 production (GO:0032655)2.94062344
134regulation of fever generation (GO:0031620)2.93381496
135positive regulation of defense response to virus by host (GO:0002230)2.92907000
136negative regulation of production of molecular mediator of immune response (GO:0002701)2.91235662
137regulation of cytokine secretion involved in immune response (GO:0002739)2.90498127
138positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.90234752
139regulation of interleukin-8 biosynthetic process (GO:0045414)2.89188367

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* IRF8_22096565_ChIP-ChIP_GC-B_Human8.86344789
2IRF8_21731497_ChIP-ChIP_J774_Mouse8.08144959
3* IRF1_21803131_ChIP-Seq_MONOCYTES_Human7.39646400
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse5.92099054
5BP1_19119308_ChIP-ChIP_Hs578T_Human5.35424280
6IRF8_27001747_Chip-Seq_BMDM_Mouse4.50652923
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.48684039
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.55077178
9* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.49453917
10RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.25826695
11GATA1_22025678_ChIP-Seq_K562_Human3.07495651
12STAT4_19710469_ChIP-ChIP_TH1__Mouse3.04438302
13Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.89254048
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.88464646
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.58226986
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.57307432
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.49116151
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.38875549
19STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.33593435
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.13922535
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.77087538
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.71752552
23* SPI1_23547873_ChIP-Seq_NB4_Human1.57796062
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.55317768
25PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.53552815
26PU_27001747_Chip-Seq_BMDM_Mouse1.50958668
27CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.50607741
28MYB_26560356_Chip-Seq_TH2_Human1.48030973
29CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.47995604
30BRD4_27068464_Chip-Seq_AML-cells_Mouse1.44486332
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.43369420
32TP63_17297297_ChIP-ChIP_HaCaT_Human1.42140273
33PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31578598
34EGR1_19032775_ChIP-ChIP_M12_Human1.27396575
35MAF_26560356_Chip-Seq_TH1_Human1.26557549
36KDM2B_26808549_Chip-Seq_SUP-B15_Human1.22797647
37MYB_26560356_Chip-Seq_TH1_Human1.22561751
38VDR_24787735_ChIP-Seq_THP-1_Human1.21353582
39GATA3_26560356_Chip-Seq_TH2_Human1.20259107
40CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19565818
41TRIM28_21343339_ChIP-Seq_HEK293_Human1.18871716
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17172311
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14858739
44STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.13676172
45FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.13223300
46CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13013561
47PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12261028
48TCF7_22412390_ChIP-Seq_EML_Mouse1.11613201
49RUNX1_22412390_ChIP-Seq_EML_Mouse1.10998402
50RUNX_20019798_ChIP-Seq_JUKART_Human1.10418399
51CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.10089512
52TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09442544
53GATA2_21666600_ChIP-Seq_HMVEC_Human1.07661754
54SPI1_23127762_ChIP-Seq_K562_Human1.05256899
55KDM2B_26808549_Chip-Seq_DND41_Human1.04323906
56VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03861410
57EGR1_23403033_ChIP-Seq_LIVER_Mouse1.01978068
58VDR_24763502_ChIP-Seq_THP-1_Human1.01194671
59* SOX2_20726797_ChIP-Seq_SW620_Human1.00891772
60GATA3_27048872_Chip-Seq_THYMUS_Human0.99162458
61PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95814528
62FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.94901334
63VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.93504575
64* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92005668
65GATA1_19941826_ChIP-Seq_K562_Human0.89558433
66RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.88976476
67NRF2_20460467_ChIP-Seq_MEFs_Mouse0.88628735
68NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.88628735
69NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.87898882
70CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.87040651
71SCL_19346495_ChIP-Seq_HPC-7_Human0.86558510
72CDX2_19796622_ChIP-Seq_MESCs_Mouse0.86330401
73KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.86159112
74KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.86041517
75TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83844488
76SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82540611
77* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.82486307
78RXR_22158963_ChIP-Seq_LIVER_Mouse0.80460562
79* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78156477
80GATA1_22383799_ChIP-Seq_G1ME_Mouse0.76812925
81LXR_22158963_ChIP-Seq_LIVER_Mouse0.76312925
82CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.75693227
83ESR2_21235772_ChIP-Seq_MCF-7_Human0.75622888
84* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.75503885
85CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.73940463
86* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.73281494
87LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.72889952
88PPARA_22158963_ChIP-Seq_LIVER_Mouse0.71183494
89MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.70281554
90SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69999406
91STAT1_20625510_ChIP-Seq_HELA_Human0.69561158
92MYC_22102868_ChIP-Seq_BL_Human0.68658963
93KDM2B_26808549_Chip-Seq_JURKAT_Human0.68351458
94SMRT_27268052_Chip-Seq_Bcells_Human0.67132023
95GATA2_19941826_ChIP-Seq_K562_Human0.66079434
96UTX_26944678_Chip-Seq_JUKART_Human0.65479374
97GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.64463539
98JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.64395818
99BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.64274648
100BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.62158393
101STAT6_21828071_ChIP-Seq_BEAS2B_Human0.61288639
102MAF_26560356_Chip-Seq_TH2_Human0.60578055
103LXR_22292898_ChIP-Seq_THP-1_Human0.60435803
104GATA1_19941827_ChIP-Seq_MEL86_Mouse0.60064496
105JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.59752243
106* CJUN_26792858_Chip-Seq_BT549_Human0.58761462
107SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.56579678
108SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.56579678
109PU.1_20513432_ChIP-Seq_Bcells_Mouse0.56351623
110ELK3_25401928_ChIP-Seq_HUVEC_Human0.55123519
111LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.54331296
112* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.53164723
113E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.52311893
114GATA1_19941827_ChIP-Seq_MEL_Mouse0.50018905
115RARG_19884340_ChIP-ChIP_MEFs_Mouse0.48916310
116* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.48573914
117IKZF1_21737484_ChIP-ChIP_HCT116_Human0.48485367
118SPI1_20517297_ChIP-Seq_HL60_Human0.48470775
119KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.47019852
120FOXO3_23340844_ChIP-Seq_DLD1_Human0.46870565
121* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.46446218
122RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.45449009
123* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.44909645
124VDR_21846776_ChIP-Seq_THP-1_Human0.44290086

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.82194563
2MP0009785_altered_susceptibility_to4.69283890
3MP0002148_abnormal_hypersensitivity_rea3.96418612
4MP0006082_CNS_inflammation3.92601939
5MP0003724_increased_susceptibility_to3.84259756
6MP0003436_decreased_susceptibility_to3.65703317
7MP0005000_abnormal_immune_tolerance3.34669136
8MP0005025_abnormal_response_to3.30688301
9MP0003303_peritoneal_inflammation3.29774728
10MP0001790_abnormal_immune_system3.23982489
11MP0005387_immune_system_phenotype3.23982489
12MP0000685_abnormal_immune_system3.23871104
13MP0004510_myositis2.98140765
14MP0002419_abnormal_innate_immunity2.97750106
15MP0005671_abnormal_response_to2.84145017
16MP0002723_abnormal_immune_serum2.63810502
17MP0002452_abnormal_antigen_presenting2.62918094
18MP0001800_abnormal_humoral_immune2.60261240
19MP0005058_abnormal_lysosome_morphology2.42706004
20MP0001533_abnormal_skeleton_physiology2.32127514
21MP0001819_abnormal_immune_cell2.21033801
22MP0009764_decreased_sensitivity_to2.18572800
23MP0004947_skin_inflammation2.17800439
24MP0002420_abnormal_adaptive_immunity2.12519347
25MP0005451_abnormal_body_composition2.05298845
26MP0008469_abnormal_protein_level1.91085909
27MP0003448_altered_tumor_morphology1.90076400
28MP0001845_abnormal_inflammatory_respons1.87989174
29MP0002006_tumorigenesis1.85514503
30MP0001853_heart_inflammation1.83071961
31MP0005464_abnormal_platelet_physiology1.79909032
32MP0003075_altered_response_to1.77395411
33MP0010155_abnormal_intestine_physiology1.70331779
34MP0000343_altered_response_to1.66594272
35MP0008004_abnormal_stomach_pH1.58006324
36MP0003172_abnormal_lysosome_physiology1.56285292
37MP0000716_abnormal_immune_system1.56182199
38MP0000604_amyloidosis1.55107011
39MP0004858_abnormal_nervous_system1.54845500
40MP0002405_respiratory_system_inflammati1.50628635
41MP0005310_abnormal_salivary_gland1.49966256
42MP0002166_altered_tumor_susceptibility1.48774076
43MP0009278_abnormal_bone_marrow1.46247927
44MP0004782_abnormal_surfactant_physiolog1.44446625
45MP0008260_abnormal_autophagy1.43896807
46MP0002398_abnormal_bone_marrow1.43533815
47MP0002139_abnormal_hepatobiliary_system1.38165279
48MP0003191_abnormal_cellular_cholesterol1.37090152
49MP0002998_abnormal_bone_remodeling1.35936598
50MP0005167_abnormal_blood-brain_barrier1.33552401
51MP0009840_abnormal_foam_cell1.32631801
52MP0009333_abnormal_splenocyte_physiolog1.32570158
53MP0010307_abnormal_tumor_latency1.30388893
54MP0005164_abnormal_response_to1.29204153
55MP0000858_altered_metastatic_potential1.26374928
56MP0001545_abnormal_hematopoietic_system1.26140331
57MP0005397_hematopoietic_system_phenotyp1.26140331
58MP0002277_abnormal_respiratory_mucosa1.24720454
59MP0006054_spinal_hemorrhage1.24569397
60MP0005166_decreased_susceptibility_to1.20957925
61MP0002429_abnormal_blood_cell1.20508807
62MP0009763_increased_sensitivity_to1.11271887
63MP0003186_abnormal_redox_activity1.11268100
64MP0003690_abnormal_glial_cell1.10218420
65MP0003806_abnormal_nucleotide_metabolis1.07924116
66MP0005390_skeleton_phenotype1.05749261
67MP0000689_abnormal_spleen_morphology1.05017254
68MP0003656_abnormal_erythrocyte_physiolo1.04535604
69MP0003300_gastrointestinal_ulcer0.99487116
70MP0002722_abnormal_immune_system0.97748356
71MP0003091_abnormal_cell_migration0.97409046
72MP0003221_abnormal_cardiomyocyte_apopto0.94778622
73MP0000569_abnormal_digit_pigmentation0.89110885
74MP0000465_gastrointestinal_hemorrhage0.87521762
75MP0009765_abnormal_xenobiotic_induced0.85343852
76MP0002163_abnormal_gland_morphology0.84098420
77MP0008438_abnormal_cutaneous_collagen0.83017529
78MP0001348_abnormal_lacrimal_gland0.82505133
79MP0003866_abnormal_defecation0.80408855
80MP0008874_decreased_physiological_sensi0.80121564
81MP0003763_abnormal_thymus_physiology0.79317829
82MP0003045_fibrosis0.78356133
83MP0002332_abnormal_exercise_endurance0.73940599
84MP0000249_abnormal_blood_vessel0.71132727
85MP0001663_abnormal_digestive_system0.70775669
86MP0001958_emphysema0.69717075
87MP0002132_abnormal_respiratory_system0.69379970
88MP0003566_abnormal_cell_adhesion0.69067069
89MP0000703_abnormal_thymus_morphology0.68998562
90MP0001851_eye_inflammation0.68762979
91MP0010352_gastrointestinal_tract_polyps0.67278500
92MP0010386_abnormal_urinary_bladder0.67274238
93MP0003453_abnormal_keratinocyte_physiol0.66614884
94MP0002933_joint_inflammation0.66385431
95MP0002138_abnormal_hepatobiliary_system0.65601864
96MP0002254_reproductive_system_inflammat0.64691526
97MP0003195_calcinosis0.64251118
98MP0004808_abnormal_hematopoietic_stem0.62135385
99MP0001542_abnormal_bone_strength0.62086789
100MP0001501_abnormal_sleep_pattern0.61233886
101MP0003828_pulmonary_edema0.60470184
102MP0002136_abnormal_kidney_physiology0.60088718
103MP0005023_abnormal_wound_healing0.59282605
104MP0005076_abnormal_cell_differentiation0.58635187
105MP0008775_abnormal_heart_ventricle0.56181920
106MP0005165_increased_susceptibility_to0.55591178
107MP0001881_abnormal_mammary_gland0.54990926
108MP0003646_muscle_fatigue0.53624205
109MP0005083_abnormal_biliary_tract0.52894458
110MP0005376_homeostasis/metabolism_phenot0.52177516
111MP0000609_abnormal_liver_physiology0.51883202
112MP0002090_abnormal_vision0.50943133
113MP0003329_amyloid_beta_deposits0.50133554
114MP0005535_abnormal_body_temperature0.50092676
115MP0003795_abnormal_bone_structure0.49150544
116MP0005319_abnormal_enzyme/_coenzyme0.46377907
117MP0003183_abnormal_peptide_metabolism0.45909955
118MP0004883_abnormal_blood_vessel0.45842225
119MP0000767_abnormal_smooth_muscle0.45654075
120MP0001915_intracranial_hemorrhage0.45230388
121MP0000920_abnormal_myelination0.45128012
122MP0002693_abnormal_pancreas_physiology0.44726445

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.77467436
2Recurrent abscess formation (HP:0002722)6.67733385
3Recurrent bacterial skin infections (HP:0005406)6.46149352
4Autoimmune thrombocytopenia (HP:0001973)6.36207730
5Increased IgM level (HP:0003496)5.55600215
6Recurrent gram-negative bacterial infections (HP:0005420)5.48523823
7Elevated erythrocyte sedimentation rate (HP:0003565)5.17289722
8Abnormality of macrophages (HP:0004311)5.08161348
9Mediastinal lymphadenopathy (HP:0100721)4.89389074
10Basal ganglia calcification (HP:0002135)4.57551129
11Systemic lupus erythematosus (HP:0002725)4.36346018
12Chronic otitis media (HP:0000389)4.30124131
13Keratoconjunctivitis (HP:0001096)4.20154250
14Vasculitis (HP:0002633)4.10786572
15Stomatitis (HP:0010280)4.05361567
16Recurrent skin infections (HP:0001581)4.01373226
17Orchitis (HP:0100796)3.93127146
18Gingivitis (HP:0000230)3.85200216
19Tetraparesis (HP:0002273)3.83671247
20Recurrent viral infections (HP:0004429)3.83104643
21Myositis (HP:0100614)3.80364908
22Hypergammaglobulinemia (HP:0010702)3.76195404
23Recurrent fungal infections (HP:0002841)3.70715419
24Optic neuritis (HP:0100653)3.67662624
25Retrobulbar optic neuritis (HP:0100654)3.67662624
26Porencephaly (HP:0002132)3.65676812
27Prostate neoplasm (HP:0100787)3.60482497
28Interstitial pulmonary disease (HP:0006530)3.55358682
29Vacuolated lymphocytes (HP:0001922)3.47526743
30Increased cerebral lipofuscin (HP:0011813)3.46372775
31T lymphocytopenia (HP:0005403)3.35204462
32Autoimmune hemolytic anemia (HP:0001890)3.34916871
33Thick nail (HP:0001805)3.32870845
34Increased neuronal autofluorescent lipopigment (HP:0002074)3.31100045
35Encephalitis (HP:0002383)3.26694360
36Periodontitis (HP:0000704)3.20804203
37Obstructive lung disease (HP:0006536)3.14982622
38Chronic obstructive pulmonary disease (HP:0006510)3.14982622
39Gangrene (HP:0100758)3.08176175
40Pustule (HP:0200039)3.07924030
41Nasal polyposis (HP:0100582)2.99302956
42Chronic mucocutaneous candidiasis (HP:0002728)2.81565665
43Recurrent cutaneous fungal infections (HP:0011370)2.81565665
44Pulmonary infiltrates (HP:0002113)2.81085226
45Osteolytic defects of the hand bones (HP:0009699)2.80468903
46Osteolytic defects of the phalanges of the hand (HP:0009771)2.80468903
47Poor head control (HP:0002421)2.77651446
48Abnormality of the nasal mucosa (HP:0000433)2.77646880
49Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.77211682
50Cellulitis (HP:0100658)2.74897239
51Abnormal delayed hypersensitivity skin test (HP:0002963)2.71703638
52Gastrointestinal infarctions (HP:0005244)2.71537784
53Pulmonary embolism (HP:0002204)2.66837867
54Urticaria (HP:0001025)2.65565656
55Amyloidosis (HP:0011034)2.64840059
56Axonal loss (HP:0003447)2.63848513
57Premature loss of primary teeth (HP:0006323)2.63057308
58Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.61999870
59Recurrent bronchitis (HP:0002837)2.61709095
60Chronic sinusitis (HP:0011109)2.60570095
61Abnormality of the endocardium (HP:0004306)2.60536360
62Episodic fever (HP:0001954)2.60300244
63Spontaneous hematomas (HP:0007420)2.60030542
64Cleft eyelid (HP:0000625)2.54108855
65Leukocytosis (HP:0001974)2.52109795
66Recurrent pneumonia (HP:0006532)2.52101291
67Increased IgE level (HP:0003212)2.49372402
68Hematochezia (HP:0002573)2.48210624
69Disinhibition (HP:0000734)2.47232973
70Purpura (HP:0000979)2.46697594
71Recurrent lower respiratory tract infections (HP:0002783)2.44668054
72Loss of speech (HP:0002371)2.39811457
73Eosinophilia (HP:0001880)2.39030262
74Joint swelling (HP:0001386)2.38538678
75Chest pain (HP:0100749)2.37644836
76Gingival bleeding (HP:0000225)2.37638198
77Osteomyelitis (HP:0002754)2.37007469
78Hemoptysis (HP:0002105)2.36362468
79Abnormality of the pericardium (HP:0001697)2.36025401
80Vertigo (HP:0002321)2.35873379
81Polyneuropathy (HP:0001271)2.34689328
82Petechiae (HP:0000967)2.33749142
83Abnormality of glycosphingolipid metabolism (HP:0004343)2.33720262
84Abnormality of glycolipid metabolism (HP:0010969)2.33720262
85Abnormality of liposaccharide metabolism (HP:0010968)2.33720262
86Abnormality of T cell number (HP:0011839)2.32206985
87Nephritis (HP:0000123)2.30561435
88Neoplasm of head and neck (HP:0012288)2.29328076
89Esophageal neoplasm (HP:0100751)2.29328076
90Cheilitis (HP:0100825)2.28994227
91Hepatosplenomegaly (HP:0001433)2.28308653
92Arterial thrombosis (HP:0004420)2.28298584
93Acne (HP:0001061)2.25205558
94Glomerulopathy (HP:0100820)2.24951933
95Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.23304535
96Myocardial infarction (HP:0001658)2.22790077
97Vertebral compression fractures (HP:0002953)2.22560006
98Glomerulonephritis (HP:0000099)2.20147902
99Keratitis (HP:0000491)2.20038553
100Meningitis (HP:0001287)2.19490511
101Lower limb hyperreflexia (HP:0002395)2.15464756
102Plagiocephaly (HP:0001357)2.13353961
103Increased serum ferritin (HP:0003281)2.13160297
104Progressive visual loss (HP:0000529)2.11389973
105Parakeratosis (HP:0001036)2.10886393
106Bone pain (HP:0002653)2.07626252
107Abnormality of the peritoneum (HP:0002585)2.06792014
108Abnormality of the basal ganglia (HP:0002134)2.06660073
109Progressive neurologic deterioration (HP:0002344)2.05798783
110Anorexia (HP:0002039)2.05578381
111Peritonitis (HP:0002586)2.03005583
112Skin ulcer (HP:0200042)2.02174545
113Granulocytopenia (HP:0001913)2.01925642
114Abnormality of the pleura (HP:0002103)2.01608327
115Keratoconjunctivitis sicca (HP:0001097)2.01424406
116IgA deficiency (HP:0002720)2.01298590
117Abnormality of mucopolysaccharide metabolism (HP:0011020)2.01223887
118Abnormality of polysaccharide metabolism (HP:0011012)2.01223887
119Abnormality of glycosaminoglycan metabolism (HP:0004371)2.01223887
120Abnormality of the prostate (HP:0008775)2.01220623
121Dysostosis multiplex (HP:0000943)1.99546971
122Prolonged neonatal jaundice (HP:0006579)1.98816644
123Abnormality of T cell physiology (HP:0011840)1.98645966
124Abnormality of eosinophils (HP:0001879)1.98348408
125Arthralgia (HP:0002829)1.97880748
126Abnormality of T cells (HP:0002843)1.95746354
127Inflammation of the large intestine (HP:0002037)1.92299827
128Thrombophlebitis (HP:0004418)1.92169064
129Mucopolysacchariduria (HP:0008155)1.91012491
130Urinary glycosaminoglycan excretion (HP:0003541)1.91012491
131Memory impairment (HP:0002354)1.90070395
132Hypochromic anemia (HP:0001931)1.89971952
133Hemorrhage of the eye (HP:0011885)1.88990795
134Epistaxis (HP:0000421)1.88670118
135Mutism (HP:0002300)1.88423810
136Amaurosis fugax (HP:0100576)1.87852741

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK5.14103204
2TYK24.51103593
3MAP3K144.46572800
4TBK14.10255977
5IKBKE3.74554613
6RIPK43.21754481
7JAK33.05084311
8BLK2.98902607
9JAK12.95716986
10IRAK42.93216968
11PIM22.60138230
12MAP3K132.46388475
13KIT2.41246014
14IKBKB2.31731930
15FGFR42.22520898
16PRPF4B2.14247672
17MAP2K31.97548042
18IRAK31.95834162
19TAOK21.83990042
20ARAF1.83290044
21TXK1.75763450
22MAP3K31.74540443
23ERN11.66241271
24MAP4K11.63028528
25CSK1.61299344
26TAOK11.60693853
27EPHB11.56448056
28EPHA31.52072884
29FGFR31.44069365
30MAP3K111.41095412
31BMPR21.37722805
32CHUK1.37547081
33MATK1.32776559
34SYK1.31158292
35MST41.30255799
36NEK91.21285246
37ZAP701.19136647
38HCK1.17402481
39BMX1.17118408
40EIF2AK21.15272367
41MAP3K51.13227413
42IRAK11.11997171
43TNK21.10872166
44FGR1.05072664
45RPS6KA41.03064743
46JAK21.00583696
47STK40.95813284
48MARK30.95579631
49ABL20.94457641
50LYN0.93946342
51LCK0.93381515
52CDC42BPA0.92837861
53PIM10.92382992
54SIK30.89592738
55MST1R0.82871584
56NME20.80118484
57FES0.74133589
58IRAK20.71187548
59HIPK20.70825777
60PRKCD0.64656995
61TAOK30.64459338
62TRPM70.63614310
63GRK60.63386499
64CSF1R0.62031658
65ERBB30.60236188
66PRKCQ0.59108822
67EGFR0.57718580
68PLK20.57635925
69BCR0.56596311
70MOS0.55678639
71ABL10.55362976
72BTK0.54695390
73CLK10.54571550
74DYRK30.54488222
75SIK20.51416525
76ITK0.50510829
77RIPK10.47705802
78TESK10.47621881
79STK100.46862214
80MAPK70.45776896
81MAP3K90.45429017
82STK30.44612087
83MAP3K60.44372365
84YES10.43167334
85DAPK30.42638594
86RPS6KA50.40866023
87GRK70.40441735
88MARK20.38572600
89ACVR1B0.38221166
90TEC0.38186794
91TRIB30.36550804
92MAP2K60.36021213
93PRKD20.35697500
94TESK20.33803074
95MAP3K10.33232652
96DYRK1B0.31670335
97TTN0.31607790
98NLK0.28321494
99MAPKAPK20.27349989
100CDK60.27170681
101ADRBK20.26986784
102LRRK20.26626461
103TGFBR20.26457897
104PKN10.26096979
105DAPK20.25469420
106KSR20.25065338
107FYN0.24629667
108CAMKK20.24277228
109PIK3CG0.23366754
110MAPK110.21401197
111MAP3K20.20232683
112PDGFRB0.20133247
113RAF10.19824781
114PRKCE0.19719023
115SRC0.18797572
116KSR10.18682070
117PTK60.18141542
118IGF1R0.18132522
119INSR0.17866380
120PDPK10.16459987
121SGK30.15933307
122ALK0.13937589
123ERBB40.13512683
124BRAF0.11416637
125PDK10.11156425
126MAPK40.11147665
127DDR20.10906630
128RPS6KA10.10133946
129PRKG20.09064898
130MAP3K100.08060495

Predicted pathways (KEGG)

RankGene SetZ-score
1Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.57984528
2Graft-versus-host disease_Homo sapiens_hsa053323.49796363
3Toll-like receptor signaling pathway_Homo sapiens_hsa046203.46731454
4Allograft rejection_Homo sapiens_hsa053303.34613306
5Leishmaniasis_Homo sapiens_hsa051403.13468780
6RIG-I-like receptor signaling pathway_Homo sapiens_hsa046223.10692584
7Staphylococcus aureus infection_Homo sapiens_hsa051502.75412045
8Measles_Homo sapiens_hsa051622.60197251
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.58829194
10Influenza A_Homo sapiens_hsa051642.56679629
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.43607090
12NOD-like receptor signaling pathway_Homo sapiens_hsa046212.28286562
13Pertussis_Homo sapiens_hsa051332.27858713
14Malaria_Homo sapiens_hsa051442.25115583
15Legionellosis_Homo sapiens_hsa051342.24076139
16Type I diabetes mellitus_Homo sapiens_hsa049402.23763330
17Rheumatoid arthritis_Homo sapiens_hsa053232.17403343
18Herpes simplex infection_Homo sapiens_hsa051682.11861291
19TNF signaling pathway_Homo sapiens_hsa046682.10588622
20Asthma_Homo sapiens_hsa053102.07200290
21Osteoclast differentiation_Homo sapiens_hsa043801.95451267
22Tuberculosis_Homo sapiens_hsa051521.93365451
23African trypanosomiasis_Homo sapiens_hsa051431.91186716
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.87569715
25Autoimmune thyroid disease_Homo sapiens_hsa053201.78661284
26Toxoplasmosis_Homo sapiens_hsa051451.66471143
27Salmonella infection_Homo sapiens_hsa051321.61180268
28Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.50736385
29Hepatitis C_Homo sapiens_hsa051601.47938095
30Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.45080418
31Antigen processing and presentation_Homo sapiens_hsa046121.42158500
32Viral myocarditis_Homo sapiens_hsa054161.39907975
33Chemokine signaling pathway_Homo sapiens_hsa040621.39672626
34Phagosome_Homo sapiens_hsa041451.39186089
35Lysosome_Homo sapiens_hsa041421.34403476
36Apoptosis_Homo sapiens_hsa042101.31712241
37Jak-STAT signaling pathway_Homo sapiens_hsa046301.31627276
38Hepatitis B_Homo sapiens_hsa051611.20737282
39Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.18096995
40Primary immunodeficiency_Homo sapiens_hsa053401.16005789
41Shigellosis_Homo sapiens_hsa051311.12566073
42B cell receptor signaling pathway_Homo sapiens_hsa046621.11254686
43Hematopoietic cell lineage_Homo sapiens_hsa046401.04980869
44Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.94084853
45Prion diseases_Homo sapiens_hsa050200.90956811
46AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.90349525
47Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.89892221
48Amoebiasis_Homo sapiens_hsa051460.85298137
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.81867963
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73781316
51Prolactin signaling pathway_Homo sapiens_hsa049170.73183810
52Glycosaminoglycan degradation_Homo sapiens_hsa005310.72123410
53Proteasome_Homo sapiens_hsa030500.59344545
54Leukocyte transendothelial migration_Homo sapiens_hsa046700.58791292
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58213459
56Adipocytokine signaling pathway_Homo sapiens_hsa049200.55403181
57T cell receptor signaling pathway_Homo sapiens_hsa046600.54779538
58Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52919750
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51160084
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51015662
61Acute myeloid leukemia_Homo sapiens_hsa052210.48817282
62Epstein-Barr virus infection_Homo sapiens_hsa051690.48535402
63Caffeine metabolism_Homo sapiens_hsa002320.47376189
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.47312896
65HIF-1 signaling pathway_Homo sapiens_hsa040660.47255229
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46587974
67Other glycan degradation_Homo sapiens_hsa005110.46300883
68Bladder cancer_Homo sapiens_hsa052190.45847074
69Small cell lung cancer_Homo sapiens_hsa052220.45392111
70Complement and coagulation cascades_Homo sapiens_hsa046100.44454087
71Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.41018375
72Viral carcinogenesis_Homo sapiens_hsa052030.40138740
73Collecting duct acid secretion_Homo sapiens_hsa049660.39769736
74Platelet activation_Homo sapiens_hsa046110.39670215
75Chronic myeloid leukemia_Homo sapiens_hsa052200.37458855
76Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36263165
77Non-small cell lung cancer_Homo sapiens_hsa052230.36079748
78Mineral absorption_Homo sapiens_hsa049780.35532801
79Type II diabetes mellitus_Homo sapiens_hsa049300.34575703
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.34280170
81Pancreatic cancer_Homo sapiens_hsa052120.33981665
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33582061
83Renal cell carcinoma_Homo sapiens_hsa052110.32611505
84Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.32151910
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.31357381
86Notch signaling pathway_Homo sapiens_hsa043300.29616191
87Dorso-ventral axis formation_Homo sapiens_hsa043200.28445443
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.24152580
89Sphingolipid metabolism_Homo sapiens_hsa006000.23412887
90Proteoglycans in cancer_Homo sapiens_hsa052050.23265948
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.23152026
92HTLV-I infection_Homo sapiens_hsa051660.20379177
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.17508594
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.15120018
95Prostate cancer_Homo sapiens_hsa052150.15072449
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.14847162
97VEGF signaling pathway_Homo sapiens_hsa043700.14340140
98GnRH signaling pathway_Homo sapiens_hsa049120.13468965
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.12856564
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.12201622
101Systemic lupus erythematosus_Homo sapiens_hsa053220.11890386
102Primary bile acid biosynthesis_Homo sapiens_hsa001200.11712291
103mTOR signaling pathway_Homo sapiens_hsa041500.11621079
104p53 signaling pathway_Homo sapiens_hsa041150.10926904
105Endometrial cancer_Homo sapiens_hsa052130.09318872
106Insulin resistance_Homo sapiens_hsa049310.07863547
107MicroRNAs in cancer_Homo sapiens_hsa052060.07862884
108FoxO signaling pathway_Homo sapiens_hsa040680.06514790
109Arginine biosynthesis_Homo sapiens_hsa002200.06195531
110Endocytosis_Homo sapiens_hsa041440.05721028
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.04159194
112Carbohydrate digestion and absorption_Homo sapiens_hsa049730.02276186
113MAPK signaling pathway_Homo sapiens_hsa040100.01354044

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