IFIT3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* type I interferon signaling pathway (GO:0060337)7.34176263
2* cellular response to type I interferon (GO:0071357)7.34176263
3* response to type I interferon (GO:0034340)7.29684594
4positive regulation of interferon-alpha production (GO:0032727)7.17456485
5regulation of interferon-alpha production (GO:0032647)6.74342748
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.52618307
7positive regulation of type I interferon-mediated signaling pathway (GO:0060340)6.03701787
8cellular response to virus (GO:0098586)5.59644228
9* response to interferon-alpha (GO:0035455)5.46499981
10negative regulation of viral genome replication (GO:0045071)5.13988910
11immunoglobulin mediated immune response (GO:0016064)5.11401518
12cellular response to interferon-beta (GO:0035458)5.08862532
13interferon-gamma-mediated signaling pathway (GO:0060333)5.08510220
14antigen processing and presentation of endogenous antigen (GO:0019883)4.94949570
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.94922131
16antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.94922131
17modulation by symbiont of host immune response (GO:0052553)4.93852069
18positive regulation by symbiont of host defense response (GO:0052509)4.93852069
19modulation by symbiont of host defense response (GO:0052031)4.93852069
20modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.93852069
21modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.93852069
22positive regulation by organism of defense response of other organism involved in symbiotic interact4.93852069
23regulation of type I interferon-mediated signaling pathway (GO:0060338)4.88391840
24cellular response to exogenous dsRNA (GO:0071360)4.87595590
25response to interferon-beta (GO:0035456)4.79149675
26positive regulation of interferon-beta production (GO:0032728)4.71110424
27regulation of RIG-I signaling pathway (GO:0039535)4.68705890
28negative regulation of interleukin-12 production (GO:0032695)4.64207875
29* cellular response to interferon-alpha (GO:0035457)4.61332618
30response to peptidoglycan (GO:0032494)4.54892744
31regulation of interferon-beta biosynthetic process (GO:0045357)4.22681980
32positive regulation of natural killer cell differentiation (GO:0032825)4.14448651
33negative regulation of cell killing (GO:0031342)4.14062436
34negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.14062436
35T cell migration (GO:0072678)4.10685944
36lipopolysaccharide-mediated signaling pathway (GO:0031663)4.07507786
37cellular response to interferon-gamma (GO:0071346)4.03701513
38B cell mediated immunity (GO:0019724)4.01305915
39regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.91291580
40neutrophil activation involved in immune response (GO:0002283)3.91204838
41positive regulation of type 2 immune response (GO:0002830)3.89730752
42response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.88312299
43response to host immune response (GO:0052572)3.88312299
44detection of molecule of bacterial origin (GO:0032490)3.79031962
45cellular response to zinc ion (GO:0071294)3.77136157
46regulation of type 2 immune response (GO:0002828)3.75589190
47lymphocyte chemotaxis (GO:0048247)3.74122061
48* defense response to virus (GO:0051607)3.70942795
49regulation of response to interferon-gamma (GO:0060330)3.65625200
50regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.64376779
51negative regulation of cytokine production involved in immune response (GO:0002719)3.64314864
52response to interferon-gamma (GO:0034341)3.58948483
53negative regulation of T cell mediated immunity (GO:0002710)3.57251602
54detection of other organism (GO:0098543)3.56867993
55regulation of vitamin D biosynthetic process (GO:0060556)3.48982729
56natural killer cell mediated immunity (GO:0002228)3.48452448
57natural killer cell mediated cytotoxicity (GO:0042267)3.48452448
58negative regulation of myeloid cell apoptotic process (GO:0033033)3.47898329
59positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.45215246
60regulation of MHC class I biosynthetic process (GO:0045343)3.44230387
61response to host (GO:0075136)3.43466640
62response to host defenses (GO:0052200)3.43466640
63response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.43466640
64regulation of T-helper 1 cell differentiation (GO:0045625)3.41761527
65positive regulation of cAMP-mediated signaling (GO:0043950)3.41496158
66macrophage activation involved in immune response (GO:0002281)3.41432954
67response to exogenous dsRNA (GO:0043330)3.38806045
68positive regulation of cytokine-mediated signaling pathway (GO:0001961)3.38792914
69regulation of interferon-beta production (GO:0032648)3.35965232
70response to protozoan (GO:0001562)3.35184667
71detection of bacterium (GO:0016045)3.32649825
72JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.32265597
73positive regulation of chemokine biosynthetic process (GO:0045080)3.32226012
74regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.31354970
75myeloid dendritic cell differentiation (GO:0043011)3.30291533
76detection of external biotic stimulus (GO:0098581)3.30264892
77regulation of chronic inflammatory response (GO:0002676)3.28188188
78T-helper 1 type immune response (GO:0042088)3.27572479
79regulation of chemokine biosynthetic process (GO:0045073)3.25451491
80negative regulation of type 2 immune response (GO:0002829)3.23310508
81positive regulation of antigen processing and presentation (GO:0002579)3.22989077
82respiratory burst (GO:0045730)3.22545922
83eosinophil chemotaxis (GO:0048245)3.22225439
84NIK/NF-kappaB signaling (GO:0038061)3.22221194
85regulation of dendritic cell antigen processing and presentation (GO:0002604)3.22135884
86positive regulation of response to cytokine stimulus (GO:0060760)3.20454797
87germinal center formation (GO:0002467)3.16960626
88natural killer cell activation involved in immune response (GO:0002323)3.15816174
89positive regulation of toll-like receptor signaling pathway (GO:0034123)3.15224486
90defense response to protozoan (GO:0042832)3.15010077
91regulation of defense response to virus by host (GO:0050691)3.14530938
92positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.13791672
93hydrogen peroxide biosynthetic process (GO:0050665)3.13556771
94positive regulation of interleukin-12 production (GO:0032735)3.12489392
95regulation of toll-like receptor signaling pathway (GO:0034121)3.12473773
96regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.08467376
97regulation of T cell tolerance induction (GO:0002664)3.07890195
98positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.07396150
99regulation of cytokine secretion involved in immune response (GO:0002739)3.07371139
100microglial cell activation (GO:0001774)3.06922817
101positive regulation of gamma-delta T cell activation (GO:0046645)3.04957386
102regulation of interleukin-12 production (GO:0032655)3.04542093
103interferon-gamma secretion (GO:0072643)3.03817606
104negative regulation of viral process (GO:0048525)3.03814997
105regulation of viral genome replication (GO:0045069)3.03404733
106regulation of gamma-delta T cell activation (GO:0046643)3.00705571
107negative regulation of type I interferon production (GO:0032480)2.97480619
108regulation of antigen processing and presentation (GO:0002577)2.96392511
109positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.93964271
110monocyte chemotaxis (GO:0002548)2.93829235
111regulation of interleukin-8 biosynthetic process (GO:0045414)2.91202729
112macrophage activation (GO:0042116)2.91030095
113negative regulation of lymphocyte mediated immunity (GO:0002707)2.90780190
114cell proliferation involved in metanephros development (GO:0072203)2.90690526
115negative regulation of innate immune response (GO:0045824)2.90491875
116lymphocyte mediated immunity (GO:0002449)2.90309608
117negative regulation of production of molecular mediator of immune response (GO:0002701)2.90056839
118response to muramyl dipeptide (GO:0032495)2.89059091
119myeloid dendritic cell activation (GO:0001773)2.88969974
120positive regulation of NF-kappaB import into nucleus (GO:0042346)2.88799297
121cytokine biosynthetic process (GO:0042089)2.88760114
122granulocyte activation (GO:0036230)2.88168024
123positive regulation of response to biotic stimulus (GO:0002833)2.86287983
124positive regulation of lymphocyte migration (GO:2000403)2.85799586
125positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.85064729
126positive regulation of T cell migration (GO:2000406)2.83685167
127regulation of mononuclear cell migration (GO:0071675)2.83022083
128regulation of B cell receptor signaling pathway (GO:0050855)2.82179549
129regulation of interferon-gamma biosynthetic process (GO:0045072)2.81776707
130positive regulation of monocyte chemotaxis (GO:0090026)2.81431688
131positive regulation of interleukin-17 production (GO:0032740)2.80614951
132regulation of natural killer cell differentiation (GO:0032823)2.80477003
133neutrophil activation (GO:0042119)2.80003733
134positive regulation of defense response to virus by host (GO:0002230)2.79763134
135eosinophil migration (GO:0072677)2.78637846
136regulation of activation of Janus kinase activity (GO:0010533)2.78265306

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* IRF8_22096565_ChIP-ChIP_GC-B_Human9.24749649
2IRF8_21731497_ChIP-ChIP_J774_Mouse7.66014726
3* IRF1_21803131_ChIP-Seq_MONOCYTES_Human7.43709044
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse6.08334080
5* FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.27753254
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.97431988
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.62026865
8STAT4_19710469_ChIP-ChIP_TH1__Mouse3.27745105
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.12590544
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.10087061
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.09820284
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.08602390
13RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.97603578
14GATA1_22025678_ChIP-Seq_K562_Human2.93210640
15STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.46143239
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.41557833
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.38228079
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.34631104
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.00175984
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.79151261
21EGR1_19374776_ChIP-ChIP_THP-1_Human1.73343527
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.70321258
23VDR_21846776_ChIP-Seq_THP-1_Human1.62587074
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.61393754
25* MYB_26560356_Chip-Seq_TH2_Human1.61267388
26TRIM28_21343339_ChIP-Seq_HEK293_Human1.57712977
27SMAD_19615063_ChIP-ChIP_OVARY_Human1.56619065
28TP63_17297297_ChIP-ChIP_HaCaT_Human1.55440211
29* MAF_26560356_Chip-Seq_TH1_Human1.53651549
30* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.48939035
31CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.44398156
32RUNX_20019798_ChIP-Seq_JUKART_Human1.43695441
33* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.42338444
34SPI1_23547873_ChIP-Seq_NB4_Human1.41366020
35BRD4_27068464_Chip-Seq_AML-cells_Mouse1.36913515
36* PU_27001747_Chip-Seq_BMDM_Mouse1.34763078
37EGR1_19032775_ChIP-ChIP_M12_Human1.32575609
38KDM2B_26808549_Chip-Seq_SUP-B15_Human1.31848154
39PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29790643
40FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.29279608
41* MYB_26560356_Chip-Seq_TH1_Human1.25676985
42CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23485866
43GATA2_21666600_ChIP-Seq_HMVEC_Human1.19473569
44SOX2_20726797_ChIP-Seq_SW620_Human1.17215547
45* GATA3_26560356_Chip-Seq_TH2_Human1.15998652
46RUNX1_22412390_ChIP-Seq_EML_Mouse1.15093358
47PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14244692
48SPI1_23127762_ChIP-Seq_K562_Human1.14183850
49TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14075210
50CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.12605838
51GATA1_19941827_ChIP-Seq_MEL_Mouse1.10484004
52ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.08284150
53RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.08269045
54CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08174656
55* KDM2B_26808549_Chip-Seq_DND41_Human1.07737862
56TCF7_22412390_ChIP-Seq_EML_Mouse1.07695223
57* GATA3_27048872_Chip-Seq_THYMUS_Human1.06768217
58VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05282713
59TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04812490
60PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03915834
61VDR_24787735_ChIP-Seq_THP-1_Human1.02120239
62TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97332641
63GATA1_19941826_ChIP-Seq_K562_Human0.95327844
64VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.95187410
65VDR_24763502_ChIP-Seq_THP-1_Human0.95047697
66PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94613507
67STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.92965386
68KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.92382837
69* UTX_26944678_Chip-Seq_JUKART_Human0.90788117
70RXR_22158963_ChIP-Seq_LIVER_Mouse0.89736471
71GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88074150
72RARG_19884340_ChIP-ChIP_MEFs_Mouse0.88060627
73PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.86920215
74PPARA_22158963_ChIP-Seq_LIVER_Mouse0.85494512
75LXR_22292898_ChIP-Seq_THP-1_Human0.84387527
76MYC_22102868_ChIP-Seq_BL_Human0.84369083
77LXR_22158963_ChIP-Seq_LIVER_Mouse0.83958179
78GATA2_22383799_ChIP-Seq_G1ME_Mouse0.83778343
79* MAF_26560356_Chip-Seq_TH2_Human0.83756742
80ESR2_21235772_ChIP-Seq_MCF-7_Human0.82500112
81* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.80783010
82FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.80687583
83SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.80312086
84GATA1_22383799_ChIP-Seq_G1ME_Mouse0.79998160
85STAT1_20625510_ChIP-Seq_HELA_Human0.79462334
86ELK3_25401928_ChIP-Seq_HUVEC_Human0.76690803
87CDX2_19796622_ChIP-Seq_MESCs_Mouse0.75943633
88CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.74020233
89* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72971556
90MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.70792444
91BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.70678739
92LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.70646879
93SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.69881545
94TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.69835783
95ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.69163636
96SCL_19346495_ChIP-Seq_HPC-7_Human0.68697424
97* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.68387827
98* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.67703704
99* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.67703704
100CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.67356091
101GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.66676132
102BCL6_27268052_Chip-Seq_Bcells_Human0.66473053
103CJUN_26792858_Chip-Seq_BT549_Human0.65252499
104NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.65069043
105SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.64994011
106TFEB_21752829_ChIP-Seq_HELA_Human0.64398784
107* KDM2B_26808549_Chip-Seq_JURKAT_Human0.62525905
108RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.62411140
109* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.62031253
110CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.61959599
111GATA2_19941826_ChIP-Seq_K562_Human0.61825263
112JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.60596724
113CTCF_26484167_Chip-Seq_Bcells_Mouse0.59284971
114* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.58186854
115P63_26484246_Chip-Seq_KERATINOCYTES_Human0.57538388
116JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.57255187
117FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.55402256
118LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.54600330
119IKZF1_21737484_ChIP-ChIP_HCT116_Human0.54092336
120CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.53104236
121* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.52914044
122SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.52899847
123SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.52899847

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.93403259
2MP0009785_altered_susceptibility_to4.68993305
3MP0003724_increased_susceptibility_to4.15479823
4MP0006082_CNS_inflammation4.00825006
5MP0002148_abnormal_hypersensitivity_rea3.32391335
6MP0005025_abnormal_response_to3.31562462
7MP0005671_abnormal_response_to3.26880347
8MP0000685_abnormal_immune_system3.21827896
9MP0005387_immune_system_phenotype3.15926061
10MP0001790_abnormal_immune_system3.15926061
11MP0003436_decreased_susceptibility_to3.12241529
12MP0005000_abnormal_immune_tolerance3.02530951
13MP0004510_myositis2.96769436
14MP0002166_altered_tumor_susceptibility2.74516339
15MP0002419_abnormal_innate_immunity2.66990219
16MP0002006_tumorigenesis2.62759000
17MP0002723_abnormal_immune_serum2.59940783
18MP0001800_abnormal_humoral_immune2.55989659
19MP0002452_abnormal_antigen_presenting2.44472550
20MP0003303_peritoneal_inflammation2.34879968
21MP0004947_skin_inflammation2.30464571
22MP0001819_abnormal_immune_cell2.15713329
23MP0001533_abnormal_skeleton_physiology2.12197027
24MP0002420_abnormal_adaptive_immunity2.09874242
25MP0009764_decreased_sensitivity_to1.99727546
26MP0008469_abnormal_protein_level1.97417344
27MP0005451_abnormal_body_composition1.92787109
28MP0001845_abnormal_inflammatory_respons1.88061406
29MP0005058_abnormal_lysosome_morphology1.83114895
30MP0000343_altered_response_to1.76817471
31MP0003448_altered_tumor_morphology1.74512323
32MP0010155_abnormal_intestine_physiology1.72156245
33MP0002405_respiratory_system_inflammati1.67735916
34MP0001853_heart_inflammation1.66915396
35MP0002998_abnormal_bone_remodeling1.63318221
36MP0005310_abnormal_salivary_gland1.59453083
37MP0000716_abnormal_immune_system1.58197186
38MP0003191_abnormal_cellular_cholesterol1.55879790
39MP0005167_abnormal_blood-brain_barrier1.50133417
40MP0003763_abnormal_thymus_physiology1.50112554
41MP0002398_abnormal_bone_marrow1.48004199
42MP0005464_abnormal_platelet_physiology1.44881166
43MP0008004_abnormal_stomach_pH1.38117108
44MP0003186_abnormal_redox_activity1.37559038
45MP0009333_abnormal_splenocyte_physiolog1.37161121
46MP0004782_abnormal_surfactant_physiolog1.34844067
47MP0003075_altered_response_to1.33555412
48MP0002138_abnormal_hepatobiliary_system1.32006027
49MP0008438_abnormal_cutaneous_collagen1.31681379
50MP0009840_abnormal_foam_cell1.30789594
51MP0002139_abnormal_hepatobiliary_system1.30528132
52MP0002254_reproductive_system_inflammat1.28494335
53MP0006054_spinal_hemorrhage1.25242971
54MP0000858_altered_metastatic_potential1.24473771
55MP0008260_abnormal_autophagy1.22463330
56MP0002429_abnormal_blood_cell1.21440374
57MP0000604_amyloidosis1.19504213
58MP0001958_emphysema1.15269045
59MP0003172_abnormal_lysosome_physiology1.15214517
60MP0009763_increased_sensitivity_to1.13583220
61MP0004883_abnormal_blood_vessel1.10947997
62MP0003300_gastrointestinal_ulcer1.10911012
63MP0003806_abnormal_nucleotide_metabolis1.10267942
64MP0000689_abnormal_spleen_morphology1.09121920
65MP0002722_abnormal_immune_system1.06783939
66MP0009278_abnormal_bone_marrow1.05325865
67MP0005166_decreased_susceptibility_to1.04728098
68MP0003045_fibrosis1.02075150
69MP0005164_abnormal_response_to0.98844141
70MP0001851_eye_inflammation0.98765584
71MP0005390_skeleton_phenotype0.95657512
72MP0003183_abnormal_peptide_metabolism0.93756527
73MP0002933_joint_inflammation0.92726144
74MP0002277_abnormal_respiratory_mucosa0.92547558
75MP0001545_abnormal_hematopoietic_system0.91565893
76MP0005397_hematopoietic_system_phenotyp0.91565893
77MP0003690_abnormal_glial_cell0.90377263
78MP0004858_abnormal_nervous_system0.90057205
79MP0003656_abnormal_erythrocyte_physiolo0.90015847
80MP0003091_abnormal_cell_migration0.89273265
81MP0003566_abnormal_cell_adhesion0.87627839
82MP0000465_gastrointestinal_hemorrhage0.84670854
83MP0005023_abnormal_wound_healing0.83650647
84MP0009765_abnormal_xenobiotic_induced0.81340403
85MP0003866_abnormal_defecation0.80675190
86MP0003453_abnormal_keratinocyte_physiol0.79738206
87MP0003195_calcinosis0.79214231
88MP0000249_abnormal_blood_vessel0.77247824
89MP0005083_abnormal_biliary_tract0.77066489
90MP0008874_decreased_physiological_sensi0.75648685
91MP0001542_abnormal_bone_strength0.73879456
92MP0001663_abnormal_digestive_system0.73242022
93MP0000920_abnormal_myelination0.72744594
94MP0004808_abnormal_hematopoietic_stem0.71324866
95MP0001348_abnormal_lacrimal_gland0.67717787
96MP0002136_abnormal_kidney_physiology0.67091288
97MP0001873_stomach_inflammation0.63529166
98MP0003221_abnormal_cardiomyocyte_apopto0.63037592
99MP0010307_abnormal_tumor_latency0.62779323
100MP0000569_abnormal_digit_pigmentation0.62090105
101MP0002877_abnormal_melanocyte_morpholog0.61825339
102MP0002332_abnormal_exercise_endurance0.61480732
103MP0003705_abnormal_hypodermis_morpholog0.60641139
104MP0001346_abnormal_lacrimal_gland0.60549755
105MP0003795_abnormal_bone_structure0.60536972
106MP0005275_abnormal_skin_tensile0.60441570
107MP0001881_abnormal_mammary_gland0.58799678
108MP0002163_abnormal_gland_morphology0.55887625
109MP0005165_increased_susceptibility_to0.55763126
110MP0000703_abnormal_thymus_morphology0.54981860
111MP0005319_abnormal_enzyme/_coenzyme0.54809517
112MP0003329_amyloid_beta_deposits0.54315321
113MP0001915_intracranial_hemorrhage0.52845288
114MP0000609_abnormal_liver_physiology0.51899095
115MP0000767_abnormal_smooth_muscle0.50624715
116MP0003879_abnormal_hair_cell0.50281795
117MP0009643_abnormal_urine_homeostasis0.49966870
118MP0003828_pulmonary_edema0.49706425
119MP0003646_muscle_fatigue0.49678353
120MP0001191_abnormal_skin_condition0.49532576

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.42567958
2Increased IgM level (HP:0003496)6.31632125
3Recurrent abscess formation (HP:0002722)5.84086060
4Elevated erythrocyte sedimentation rate (HP:0003565)5.56511355
5Recurrent bacterial skin infections (HP:0005406)5.38974194
6Autoimmune thrombocytopenia (HP:0001973)5.15423738
7Recurrent gram-negative bacterial infections (HP:0005420)4.88785838
8Recurrent cutaneous fungal infections (HP:0011370)4.65474310
9Chronic mucocutaneous candidiasis (HP:0002728)4.65474310
10Basal ganglia calcification (HP:0002135)4.45274936
11Recurrent skin infections (HP:0001581)4.36590762
12Systemic lupus erythematosus (HP:0002725)4.32709033
13Keratoconjunctivitis sicca (HP:0001097)4.31453575
14Abnormality of macrophages (HP:0004311)4.22561784
15Recurrent fungal infections (HP:0002841)4.11178879
16Mediastinal lymphadenopathy (HP:0100721)4.06786527
17Hypergammaglobulinemia (HP:0010702)4.00043730
18Keratoconjunctivitis (HP:0001096)3.97218134
19Autoimmune hemolytic anemia (HP:0001890)3.83044289
20Chronic otitis media (HP:0000389)3.81279172
21Vasculitis (HP:0002633)3.72009400
22Recurrent viral infections (HP:0004429)3.53990913
23Gingivitis (HP:0000230)3.52721434
24Orchitis (HP:0100796)3.50935767
25Interstitial pulmonary disease (HP:0006530)3.50277810
26Recurrent bronchitis (HP:0002837)3.45220598
27Myositis (HP:0100614)3.38376360
28Stomatitis (HP:0010280)3.36453565
29Abnormality of T cell number (HP:0011839)3.36257983
30Pustule (HP:0200039)3.33515187
31Abnormality of the nasal mucosa (HP:0000433)3.14202866
32Encephalitis (HP:0002383)3.09748363
33Thick nail (HP:0001805)3.08202627
34Retrobulbar optic neuritis (HP:0100654)3.05727951
35Optic neuritis (HP:0100653)3.05727951
36Tetraparesis (HP:0002273)3.04054559
37Periodontitis (HP:0000704)2.99889003
38Vacuolated lymphocytes (HP:0001922)2.99031281
39Porencephaly (HP:0002132)2.98889899
40Hemoptysis (HP:0002105)2.96757424
41Gangrene (HP:0100758)2.90582631
42T lymphocytopenia (HP:0005403)2.89674931
43Nasal polyposis (HP:0100582)2.88791377
44Increased cerebral lipofuscin (HP:0011813)2.87669631
45Prostate neoplasm (HP:0100787)2.87332000
46Abnormal delayed hypersensitivity skin test (HP:0002963)2.82115605
47Leukocytosis (HP:0001974)2.82018459
48Increased neuronal autofluorescent lipopigment (HP:0002074)2.79405318
49Osteolytic defects of the hand bones (HP:0009699)2.75451272
50Osteolytic defects of the phalanges of the hand (HP:0009771)2.75451272
51Pulmonary infiltrates (HP:0002113)2.74492880
52Cheilitis (HP:0100825)2.73842991
53Obstructive lung disease (HP:0006536)2.73576776
54Chronic obstructive pulmonary disease (HP:0006510)2.73576776
55Increased IgE level (HP:0003212)2.68848424
56Joint swelling (HP:0001386)2.63754417
57Combined immunodeficiency (HP:0005387)2.63355921
58IgG deficiency (HP:0004315)2.63351817
59Disinhibition (HP:0000734)2.62548285
60Dysostosis multiplex (HP:0000943)2.60559252
61Abnormality of the pleura (HP:0002103)2.58144106
62Abnormality of eosinophils (HP:0001879)2.58093279
63Chronic diarrhea (HP:0002028)2.57720444
64Severe combined immunodeficiency (HP:0004430)2.57565016
65Abnormality of the endocardium (HP:0004306)2.56899977
66Gastrointestinal infarctions (HP:0005244)2.55789809
67Purpura (HP:0000979)2.53922365
68Vertebral compression fractures (HP:0002953)2.53522525
69Hematochezia (HP:0002573)2.52759927
70Urticaria (HP:0001025)2.51056596
71Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.48783904
72Pulmonary embolism (HP:0002204)2.48559106
73Spontaneous hematomas (HP:0007420)2.48123922
74Thyroiditis (HP:0100646)2.44744958
75Abnormality of T cells (HP:0002843)2.44418266
76Nephritis (HP:0000123)2.43979796
77Amyloidosis (HP:0011034)2.43492455
78Eosinophilia (HP:0001880)2.43398700
79Progressive neurologic deterioration (HP:0002344)2.41265025
80IgA deficiency (HP:0002720)2.40368088
81Episodic fever (HP:0001954)2.39077895
82Gingival bleeding (HP:0000225)2.38599495
83Chronic sinusitis (HP:0011109)2.33788488
84Abnormality of glycolipid metabolism (HP:0010969)2.32696081
85Abnormality of liposaccharide metabolism (HP:0010968)2.32696081
86Abnormality of glycosphingolipid metabolism (HP:0004343)2.32696081
87Abnormality of the pericardium (HP:0001697)2.27075123
88Cellulitis (HP:0100658)2.25156341
89Polyneuropathy (HP:0001271)2.24005777
90Axonal loss (HP:0003447)2.23805965
91Keratitis (HP:0000491)2.23361633
92Hypoplasia of the thymus (HP:0000778)2.19959009
93Myocardial infarction (HP:0001658)2.19847742
94Arterial thrombosis (HP:0004420)2.18782925
95Vertigo (HP:0002321)2.18767446
96Abnormality of B cell number (HP:0010975)2.18604236
97Glomerulopathy (HP:0100820)2.18374599
98Acne (HP:0001061)2.17290049
99Glomerulonephritis (HP:0000099)2.17249955
100Abnormality of cells of the lymphoid lineage (HP:0012140)2.17132245
101Hepatosplenomegaly (HP:0001433)2.17089931
102Petechiae (HP:0000967)2.16667296
103Chest pain (HP:0100749)2.16032207
104Abnormality of the basal ganglia (HP:0002134)2.15653049
105Parakeratosis (HP:0001036)2.15514588
106Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.15323578
107Recurrent pneumonia (HP:0006532)2.15236449
108Increased serum ferritin (HP:0003281)2.14444106
109Premature loss of primary teeth (HP:0006323)2.14195000
110Abnormality of the peritoneum (HP:0002585)2.11915316
111Loss of speech (HP:0002371)2.11758011
112Esophageal varix (HP:0002040)2.11246317
113Mitral stenosis (HP:0001718)2.09185721
114Peritonitis (HP:0002586)2.08072924
115Arthralgia (HP:0002829)2.06865926
116Lymphopenia (HP:0001888)2.06349767
117Hemorrhage of the eye (HP:0011885)2.05023257
118Skin ulcer (HP:0200042)2.04882293
119Gastrointestinal stroma tumor (HP:0100723)2.04289020
120Meningitis (HP:0001287)2.02961406
121Abnormality of glycosaminoglycan metabolism (HP:0004371)2.02780065
122Abnormality of mucopolysaccharide metabolism (HP:0011020)2.02780065
123Abnormality of polysaccharide metabolism (HP:0011012)2.02780065
124Granulocytopenia (HP:0001913)2.01066786
125Recurrent lower respiratory tract infections (HP:0002783)2.00091789
126Hypochromic anemia (HP:0001931)1.98872483
127Osteomyelitis (HP:0002754)1.97713805
128Anorexia (HP:0002039)1.96856965
129Poor head control (HP:0002421)1.96818962
130Cleft eyelid (HP:0000625)1.95194128
131Hypochromic microcytic anemia (HP:0004840)1.94914077
132Bone pain (HP:0002653)1.94763973
133B lymphocytopenia (HP:0010976)1.94050832
134Emphysema (HP:0002097)1.93900618
135Bronchitis (HP:0012387)1.93852773

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IKBKE5.18371912
2FGFR45.10465445
3TYK24.88594416
4TBK14.40473398
5MAP3K143.75029682
6JAK33.71095419
7KIT3.68661936
8JAK13.23847483
9PBK3.10294599
10FGFR32.87600015
11TXK2.83837870
12IRAK42.29057998
13PRPF4B2.24487790
14BLK2.22294122
15MAP2K32.01784656
16TAOK21.95750348
17RIPK41.95242960
18ERN11.94400930
19MAP4K11.94387031
20IKBKB1.83543550
21MAP3K31.83229788
22TAOK11.62277569
23CSK1.53870073
24MAP3K131.50260222
25ZAP701.46996399
26MAP3K111.46676936
27EPHB11.40660601
28PIM21.35595473
29NEK91.34086273
30EPHA31.33008988
31MST41.25022826
32JAK21.22347802
33CDC42BPA1.16328952
34HCK1.12543570
35LCK1.07615668
36CHUK1.05864629
37SYK1.04502015
38TNK20.98000797
39IRAK30.93080773
40KDR0.92194204
41MAPK110.90078203
42BMPR20.89078006
43RPS6KA40.88481002
44BMX0.83482817
45IRAK10.83075879
46LYN0.81169965
47TESK10.80138143
48EIF2AK20.77621530
49TGFBR20.74585982
50RIPK10.73393950
51HIPK20.73001718
52CSF1R0.71891464
53MATK0.69566429
54SIK30.69289723
55TIE10.68164432
56BTK0.66949560
57ARAF0.66714219
58PRKCD0.63661602
59MARK30.63514541
60FGR0.63087360
61PRKD20.62540906
62EGFR0.61225615
63ABL20.60633245
64PRKCH0.58628978
65MAP3K120.58232263
66RPS6KA50.54732609
67MAP2K60.54363082
68MAP3K50.54272651
69MST1R0.53696427
70MAPK70.52955265
71KSR20.52672044
72CLK10.51515928
73STK100.50363433
74TRPM70.48994433
75TTN0.48865577
76ABL10.48751726
77TEC0.47974290
78BCR0.47735152
79LRRK20.45503920
80SIK10.43797646
81PRKCQ0.43303289
82FES0.43029113
83IRAK20.42952066
84PIM10.40791768
85MAP3K60.40281793
86PDPK10.37393029
87STK40.37343188
88TRIB30.36724181
89NLK0.35859599
90YES10.35550799
91PTK60.35294923
92MARK20.34498231
93NME20.34341648
94ITK0.34240382
95DAPK30.33599201
96TLK10.33553992
97DYRK30.33013502
98FYN0.32154726
99MOS0.31130062
100IGF1R0.30712424
101DDR20.30669823
102ERBB30.30021426
103TAOK30.29977925
104SIK20.29876994
105INSR0.28754785
106SRC0.26937954
107DAPK20.26255873
108MAPK40.24889615
109ACVR1B0.23683479
110CAMK2G0.23643301
111PDK10.22277174
112MAP3K10.21748605
113GRK70.21277490
114DYRK1B0.21043140
115MAPKAPK20.20385607
116PKN10.18626775
117MYLK0.17712575
118TYRO30.16892958
119CDK60.16841804
120PRKG20.15934747
121TESK20.15466878
122ADRBK20.13010710
123PDGFRB0.12129729
124PLK20.10837987
125GRK60.10742983
126ERBB40.08766309
127TGFBR10.07755395
128PTK20.07078205

Predicted pathways (KEGG)

RankGene SetZ-score
1Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.47459884
2Graft-versus-host disease_Homo sapiens_hsa053323.40571559
3Toll-like receptor signaling pathway_Homo sapiens_hsa046203.20694515
4Allograft rejection_Homo sapiens_hsa053303.15872640
5RIG-I-like receptor signaling pathway_Homo sapiens_hsa046223.07676976
6Leishmaniasis_Homo sapiens_hsa051403.02882833
7Staphylococcus aureus infection_Homo sapiens_hsa051502.97106933
8Measles_Homo sapiens_hsa051622.93559140
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.52663144
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.51562940
11Influenza A_Homo sapiens_hsa051642.46647705
12Malaria_Homo sapiens_hsa051442.32935579
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.32240178
14Asthma_Homo sapiens_hsa053102.27084979
15Herpes simplex infection_Homo sapiens_hsa051682.20149214
16Primary immunodeficiency_Homo sapiens_hsa053402.16329683
17Osteoclast differentiation_Homo sapiens_hsa043801.99460372
18Pertussis_Homo sapiens_hsa051331.98928307
19Legionellosis_Homo sapiens_hsa051341.97700704
20Antigen processing and presentation_Homo sapiens_hsa046121.94204597
21African trypanosomiasis_Homo sapiens_hsa051431.83433582
22Rheumatoid arthritis_Homo sapiens_hsa053231.80979702
23Caffeine metabolism_Homo sapiens_hsa002321.80144196
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.77804237
25Type I diabetes mellitus_Homo sapiens_hsa049401.76234607
26TNF signaling pathway_Homo sapiens_hsa046681.74412805
27Tuberculosis_Homo sapiens_hsa051521.72536567
28Toxoplasmosis_Homo sapiens_hsa051451.72003049
29Autoimmune thyroid disease_Homo sapiens_hsa053201.70188644
30Viral myocarditis_Homo sapiens_hsa054161.61102317
31Hepatitis C_Homo sapiens_hsa051601.56154487
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.53306345
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.48181339
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.45676596
35Lysosome_Homo sapiens_hsa041421.42928996
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.42017667
37Salmonella infection_Homo sapiens_hsa051321.32906097
38Hematopoietic cell lineage_Homo sapiens_hsa046401.32453193
39Chemokine signaling pathway_Homo sapiens_hsa040621.30180135
40Phagosome_Homo sapiens_hsa041451.22899191
41Hepatitis B_Homo sapiens_hsa051611.22370153
42Apoptosis_Homo sapiens_hsa042101.21223851
43B cell receptor signaling pathway_Homo sapiens_hsa046620.97314531
44Shigellosis_Homo sapiens_hsa051310.96963523
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.91174141
46Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89648610
47Glycosaminoglycan degradation_Homo sapiens_hsa005310.88181798
48Complement and coagulation cascades_Homo sapiens_hsa046100.87792909
49T cell receptor signaling pathway_Homo sapiens_hsa046600.80235087
50Prion diseases_Homo sapiens_hsa050200.77973819
51Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.77153070
52Leukocyte transendothelial migration_Homo sapiens_hsa046700.76644168
53Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.76096470
54Amoebiasis_Homo sapiens_hsa051460.75714027
55Proteasome_Homo sapiens_hsa030500.75147959
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73513823
57Other glycan degradation_Homo sapiens_hsa005110.73142436
58Prolactin signaling pathway_Homo sapiens_hsa049170.73043313
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67074684
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60784781
61Bladder cancer_Homo sapiens_hsa052190.54654324
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.51536530
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50904528
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.48240201
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47064757
66Pancreatic cancer_Homo sapiens_hsa052120.45966528
67Dorso-ventral axis formation_Homo sapiens_hsa043200.40106398
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37873845
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.37527170
70Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35779591
71FoxO signaling pathway_Homo sapiens_hsa040680.35035348
72Viral carcinogenesis_Homo sapiens_hsa052030.35000081
73Epstein-Barr virus infection_Homo sapiens_hsa051690.34419994
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.33478809
75Platelet activation_Homo sapiens_hsa046110.29947349
76HIF-1 signaling pathway_Homo sapiens_hsa040660.27833180
77Small cell lung cancer_Homo sapiens_hsa052220.26746846
78Notch signaling pathway_Homo sapiens_hsa043300.26261083
79Sphingolipid metabolism_Homo sapiens_hsa006000.25823106
80Systemic lupus erythematosus_Homo sapiens_hsa053220.25560080
81HTLV-I infection_Homo sapiens_hsa051660.24794843
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24538295
83Mineral absorption_Homo sapiens_hsa049780.24374280
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.23764864
85Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.23171944
86Non-small cell lung cancer_Homo sapiens_hsa052230.22518445
87MAPK signaling pathway_Homo sapiens_hsa040100.22452756
88Renal cell carcinoma_Homo sapiens_hsa052110.22332615
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.21602671
90Acute myeloid leukemia_Homo sapiens_hsa052210.18848595
91Arginine biosynthesis_Homo sapiens_hsa002200.17875881
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.15145984
93ECM-receptor interaction_Homo sapiens_hsa045120.14042201
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.14023406
95GnRH signaling pathway_Homo sapiens_hsa049120.13454422
96Proteoglycans in cancer_Homo sapiens_hsa052050.13066789
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.11628750
98VEGF signaling pathway_Homo sapiens_hsa043700.11207750
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.10947836
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.10374338
101Galactose metabolism_Homo sapiens_hsa000520.09822166
102Insulin resistance_Homo sapiens_hsa049310.09776346
103Focal adhesion_Homo sapiens_hsa045100.09600406
104Transcriptional misregulation in cancer_Homo sapiens_hsa052020.09159842
105Chronic myeloid leukemia_Homo sapiens_hsa052200.09096989
106Collecting duct acid secretion_Homo sapiens_hsa049660.08455396
107mTOR signaling pathway_Homo sapiens_hsa041500.08059874
108Type II diabetes mellitus_Homo sapiens_hsa049300.07940032
109Endocytosis_Homo sapiens_hsa041440.07938704
110Prostate cancer_Homo sapiens_hsa052150.07776810
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.05992705
112PPAR signaling pathway_Homo sapiens_hsa033200.05831877
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.05753827
114Peroxisome_Homo sapiens_hsa041460.05477050
115ABC transporters_Homo sapiens_hsa020100.05065289
116Fatty acid biosynthesis_Homo sapiens_hsa000610.03398505

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