

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | type I interferon signaling pathway (GO:0060337) | 6.29042890 |
| 2 | cellular response to type I interferon (GO:0071357) | 6.29042890 |
| 3 | response to type I interferon (GO:0034340) | 6.16121841 |
| 4 | cellular response to interferon-alpha (GO:0035457) | 5.37504801 |
| 5 | response to interferon-alpha (GO:0035455) | 5.03122775 |
| 6 | regulation of interferon-alpha production (GO:0032647) | 4.45668317 |
| 7 | negative regulation of cell killing (GO:0031342) | 4.44579276 |
| 8 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 4.44579276 |
| 9 | negative regulation of interleukin-12 production (GO:0032695) | 4.41924245 |
| 10 | modulation by symbiont of host immune response (GO:0052553) | 4.36367834 |
| 11 | positive regulation by symbiont of host defense response (GO:0052509) | 4.36367834 |
| 12 | modulation by symbiont of host defense response (GO:0052031) | 4.36367834 |
| 13 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 4.36367834 |
| 14 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 4.36367834 |
| 15 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 4.36367834 |
| 16 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 4.34638779 |
| 17 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 4.29611297 |
| 18 | negative regulation of viral genome replication (GO:0045071) | 4.23434762 |
| 19 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 4.20827935 |
| 20 | macrophage activation involved in immune response (GO:0002281) | 4.19543751 |
| 21 | positive regulation of interferon-alpha production (GO:0032727) | 4.18561244 |
| 22 | positive regulation of gamma-delta T cell activation (GO:0046645) | 4.09479976 |
| 23 | positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770) | 4.05184438 |
| 24 | regulation of interferon-beta biosynthetic process (GO:0045357) | 3.96691424 |
| 25 | interferon-gamma-mediated signaling pathway (GO:0060333) | 3.94779498 |
| 26 | detection of molecule of bacterial origin (GO:0032490) | 3.88461935 |
| 27 | antigen processing and presentation of endogenous antigen (GO:0019883) | 3.70163544 |
| 28 | regulation of T-helper 1 cell differentiation (GO:0045625) | 3.64083305 |
| 29 | positive regulation of interferon-beta production (GO:0032728) | 3.59499096 |
| 30 | response to peptidoglycan (GO:0032494) | 3.55114157 |
| 31 | regulation of interleukin-8 biosynthetic process (GO:0045414) | 3.44188309 |
| 32 | microglial cell activation (GO:0001774) | 3.42861532 |
| 33 | negative regulation of T cell mediated immunity (GO:0002710) | 3.40110654 |
| 34 | positive regulation of interleukin-8 biosynthetic process (GO:0045416) | 3.39871939 |
| 35 | response to host immune response (GO:0052572) | 3.36782302 |
| 36 | response to immune response of other organism involved in symbiotic interaction (GO:0052564) | 3.36782302 |
| 37 | positive regulation of type 2 immune response (GO:0002830) | 3.35193109 |
| 38 | positive regulation of toll-like receptor signaling pathway (GO:0034123) | 3.28645143 |
| 39 | detection of other organism (GO:0098543) | 3.25026375 |
| 40 | regulation of type I interferon-mediated signaling pathway (GO:0060338) | 3.23215091 |
| 41 | * defense response to virus (GO:0051607) | 3.20360335 |
| 42 | defense response to protozoan (GO:0042832) | 3.13633838 |
| 43 | interferon-gamma production (GO:0032609) | 3.13207430 |
| 44 | cellular response to interleukin-15 (GO:0071350) | 3.10901072 |
| 45 | response to interferon-beta (GO:0035456) | 3.09646977 |
| 46 | detection of external biotic stimulus (GO:0098581) | 3.09482816 |
| 47 | T cell migration (GO:0072678) | 3.05265996 |
| 48 | response to host (GO:0075136) | 3.04914768 |
| 49 | response to host defenses (GO:0052200) | 3.04914768 |
| 50 | response to defenses of other organism involved in symbiotic interaction (GO:0052173) | 3.04914768 |
| 51 | response to interleukin-15 (GO:0070672) | 3.04658597 |
| 52 | neutrophil mediated immunity (GO:0002446) | 3.03777321 |
| 53 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 3.02870681 |
| 54 | macrophage activation (GO:0042116) | 3.01620069 |
| 55 | NIK/NF-kappaB signaling (GO:0038061) | 3.01130719 |
| 56 | myeloid dendritic cell differentiation (GO:0043011) | 2.99926704 |
| 57 | regulation of regulatory T cell differentiation (GO:0045589) | 2.99599186 |
| 58 | regulation of RIG-I signaling pathway (GO:0039535) | 2.99383641 |
| 59 | regulation of nitric-oxide synthase biosynthetic process (GO:0051769) | 2.97575080 |
| 60 | regulation of T cell tolerance induction (GO:0002664) | 2.96156599 |
| 61 | lipopolysaccharide-mediated signaling pathway (GO:0031663) | 2.94672949 |
| 62 | regulation of cytokine secretion involved in immune response (GO:0002739) | 2.94477888 |
| 63 | regulation of type 2 immune response (GO:0002828) | 2.94029564 |
| 64 | regulation of viral genome replication (GO:0045069) | 2.92018393 |
| 65 | regulation of MHC class I biosynthetic process (GO:0045343) | 2.91387698 |
| 66 | cellular response to interferon-gamma (GO:0071346) | 2.85362834 |
| 67 | regulation of dendritic cell antigen processing and presentation (GO:0002604) | 2.84820455 |
| 68 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 2.83474888 |
| 69 | detection of bacterium (GO:0016045) | 2.83442956 |
| 70 | T-helper 1 type immune response (GO:0042088) | 2.81868497 |
| 71 | interleukin-6-mediated signaling pathway (GO:0070102) | 2.81542787 |
| 72 | regulation of interleukin-12 production (GO:0032655) | 2.80858341 |
| 73 | leukocyte aggregation (GO:0070486) | 2.80793817 |
| 74 | germinal center formation (GO:0002467) | 2.79841036 |
| 75 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 2.79549653 |
| 76 | regulation of chronic inflammatory response (GO:0002676) | 2.79028069 |
| 77 | production of molecular mediator involved in inflammatory response (GO:0002532) | 2.77594133 |
| 78 | negative regulation of cytokine production involved in immune response (GO:0002719) | 2.77045590 |
| 79 | positive regulation of NF-kappaB import into nucleus (GO:0042346) | 2.76041088 |
| 80 | cellular response to exogenous dsRNA (GO:0071360) | 2.74327822 |
| 81 | regulation of vitamin D biosynthetic process (GO:0060556) | 2.73126563 |
| 82 | cellular response to interferon-beta (GO:0035458) | 2.72749305 |
| 83 | regulation of response to interferon-gamma (GO:0060330) | 2.71990742 |
| 84 | regulation of interferon-beta production (GO:0032648) | 2.71300887 |
| 85 | response to protozoan (GO:0001562) | 2.70720570 |
| 86 | negative regulation of viral process (GO:0048525) | 2.70318772 |
| 87 | response to interferon-gamma (GO:0034341) | 2.69251949 |
| 88 | activated T cell proliferation (GO:0050798) | 2.69011480 |
| 89 | regulation of gamma-delta T cell activation (GO:0046643) | 2.67613304 |
| 90 | positive regulation of acute inflammatory response (GO:0002675) | 2.67010694 |
| 91 | regulation of interleukin-1 beta secretion (GO:0050706) | 2.66950828 |
| 92 | interferon-gamma secretion (GO:0072643) | 2.65802825 |
| 93 | positive regulation of interleukin-1 beta secretion (GO:0050718) | 2.65658342 |
| 94 | regulation of B cell receptor signaling pathway (GO:0050855) | 2.65612662 |
| 95 | myeloid leukocyte mediated immunity (GO:0002444) | 2.65494398 |
| 96 | positive regulation of natural killer cell differentiation (GO:0032825) | 2.64876643 |
| 97 | negative regulation of type 2 immune response (GO:0002829) | 2.64678190 |
| 98 | immunoglobulin mediated immune response (GO:0016064) | 2.61801831 |
| 99 | detection of biotic stimulus (GO:0009595) | 2.59792199 |
| 100 | neutrophil activation involved in immune response (GO:0002283) | 2.59107194 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | * IRF8_22096565_ChIP-ChIP_GC-B_Human | 5.95760536 |
| 2 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 5.17767149 |
| 3 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 4.66316157 |
| 4 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 4.50364266 |
| 5 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 4.45821528 |
| 6 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 3.35937911 |
| 7 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 2.98984461 |
| 8 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.89682449 |
| 9 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 2.75431640 |
| 10 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 2.52672047 |
| 11 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 2.37368177 |
| 12 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 2.24938506 |
| 13 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 2.20099906 |
| 14 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.13074594 |
| 15 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 2.05634547 |
| 16 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.02931594 |
| 17 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.99955878 |
| 18 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.96925743 |
| 19 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.89560368 |
| 20 | GATA1_22025678_ChIP-Seq_K562_Human | 1.88687525 |
| 21 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 1.87056440 |
| 22 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.84153599 |
| 23 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.78077469 |
| 24 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.67465452 |
| 25 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.64255039 |
| 26 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.62121147 |
| 27 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.57765962 |
| 28 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.54963959 |
| 29 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.54238054 |
| 30 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.50528739 |
| 31 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.48704977 |
| 32 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.46336125 |
| 33 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.45334452 |
| 34 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.44789067 |
| 35 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.42982352 |
| 36 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.41769294 |
| 37 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.36195200 |
| 38 | CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse | 1.32491100 |
| 39 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.31220400 |
| 40 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.30863561 |
| 41 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 1.28513361 |
| 42 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 1.28513361 |
| 43 | P300_19829295_ChIP-Seq_ESCs_Human | 1.24799801 |
| 44 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.23622978 |
| 45 | GATA3_26560356_Chip-Seq_TH2_Human | 1.23410670 |
| 46 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.21523036 |
| 47 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 1.21059287 |
| 48 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 1.17013655 |
| 49 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.15817021 |
| 50 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.14986258 |
| 51 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.14399251 |
| 52 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 1.14005619 |
| 53 | * MYB_26560356_Chip-Seq_TH2_Human | 1.13330587 |
| 54 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 1.10697881 |
| 55 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 1.10608670 |
| 56 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.10482297 |
| 57 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 1.10383673 |
| 58 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.08044021 |
| 59 | CMYC_18555785_Chip-Seq_ESCs_Mouse | 1.06666184 |
| 60 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 1.06511915 |
| 61 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.06326425 |
| 62 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.05243956 |
| 63 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.03686468 |
| 64 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.03325860 |
| 65 | * GATA3_27048872_Chip-Seq_THYMUS_Human | 1.02463504 |
| 66 | P53_22387025_ChIP-Seq_ESCs_Mouse | 1.02175611 |
| 67 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.01582588 |
| 68 | SUZ12_18555785_Chip-Seq_ESCs_Mouse | 1.00738104 |
| 69 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.00249711 |
| 70 | TAL1_26923725_Chip-Seq_HPCs_Mouse | 0.98078732 |
| 71 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 0.98029194 |
| 72 | EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse | 0.97407444 |
| 73 | CJUN_26792858_Chip-Seq_BT549_Human | 0.96631511 |
| 74 | STAT3_23295773_ChIP-Seq_U87_Human | 0.96319255 |
| 75 | BRD4_25478319_ChIP-Seq_HGPS_Human | 0.96228960 |
| 76 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 0.95967280 |
| 77 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 0.94475505 |
| 78 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.94279425 |
| 79 | TP53_16413492_ChIP-PET_HCT116_Human | 0.93093543 |
| 80 | TP53_18474530_ChIP-ChIP_U2OS_Human | 0.93070016 |
| 81 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.92494867 |
| 82 | OCT4_21477851_ChIP-Seq_ESCs_Mouse | 0.92212569 |
| 83 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.90961983 |
| 84 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 0.90669871 |
| 85 | PU_27001747_Chip-Seq_BMDM_Mouse | 0.90600008 |
| 86 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.89944797 |
| 87 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 0.89675716 |
| 88 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 0.88792767 |
| 89 | KDM2B_26808549_Chip-Seq_REH_Human | 0.85727973 |
| 90 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.85027941 |
| 91 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.85027941 |
| 92 | SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse | 0.83523908 |
| 93 | STAT3_18555785_Chip-Seq_ESCs_Mouse | 0.83049137 |
| 94 | P300_18555785_Chip-Seq_ESCs_Mouse | 0.83048192 |
| 95 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 0.81989608 |
| 96 | NMYC_18555785_Chip-Seq_ESCs_Mouse | 0.81720245 |
| 97 | AR_25329375_ChIP-Seq_VCAP_Human | 0.81542110 |
| 98 | SOX2_20726797_ChIP-Seq_SW620_Human | 0.80984446 |
| 99 | CDX2_22108803_ChIP-Seq_LS180_Human | 0.80866870 |
| 100 | SMRT_27268052_Chip-Seq_Bcells_Human | 0.80039971 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003724_increased_susceptibility_to | 5.42814772 |
| 2 | MP0003303_peritoneal_inflammation | 4.37592650 |
| 3 | MP0001835_abnormal_antigen_presentation | 3.86730417 |
| 4 | MP0006082_CNS_inflammation | 3.46660786 |
| 5 | MP0009785_altered_susceptibility_to | 3.43959514 |
| 6 | MP0005387_immune_system_phenotype | 2.91278127 |
| 7 | MP0001790_abnormal_immune_system | 2.91278127 |
| 8 | MP0003436_decreased_susceptibility_to | 2.83573269 |
| 9 | MP0000569_abnormal_digit_pigmentation | 2.69510994 |
| 10 | MP0005000_abnormal_immune_tolerance | 2.54831685 |
| 11 | MP0004510_myositis | 2.48436893 |
| 12 | MP0005671_abnormal_response_to | 2.47881792 |
| 13 | MP0002148_abnormal_hypersensitivity_rea | 2.44651081 |
| 14 | MP0001800_abnormal_humoral_immune | 2.43761580 |
| 15 | MP0005025_abnormal_response_to | 2.41452476 |
| 16 | MP0002419_abnormal_innate_immunity | 2.27630033 |
| 17 | MP0002723_abnormal_immune_serum | 2.25222982 |
| 18 | MP0003300_gastrointestinal_ulcer | 2.21515601 |
| 19 | MP0000685_abnormal_immune_system | 2.16642603 |
| 20 | MP0002452_abnormal_antigen_presenting | 2.12030290 |
| 21 | MP0009764_decreased_sensitivity_to | 2.11121520 |
| 22 | MP0004883_abnormal_blood_vessel | 1.94925582 |
| 23 | MP0006054_spinal_hemorrhage | 1.91105714 |
| 24 | MP0002332_abnormal_exercise_endurance | 1.89203379 |
| 25 | MP0001533_abnormal_skeleton_physiology | 1.79767516 |
| 26 | MP0001819_abnormal_immune_cell | 1.78178569 |
| 27 | MP0002420_abnormal_adaptive_immunity | 1.78040974 |
| 28 | MP0003191_abnormal_cellular_cholesterol | 1.72376714 |
| 29 | MP0001845_abnormal_inflammatory_respons | 1.72118196 |
| 30 | MP0005164_abnormal_response_to | 1.67241692 |
| 31 | MP0002405_respiratory_system_inflammati | 1.59688894 |
| 32 | MP0003221_abnormal_cardiomyocyte_apopto | 1.59234961 |
| 33 | MP0003690_abnormal_glial_cell | 1.57437949 |
| 34 | MP0000465_gastrointestinal_hemorrhage | 1.56583567 |
| 35 | MP0010155_abnormal_intestine_physiology | 1.51768296 |
| 36 | MP0008469_abnormal_protein_level | 1.47005090 |
| 37 | MP0008260_abnormal_autophagy | 1.46004818 |
| 38 | MP0005310_abnormal_salivary_gland | 1.45468199 |
| 39 | MP0003656_abnormal_erythrocyte_physiolo | 1.44556154 |
| 40 | MP0000343_altered_response_to | 1.35969669 |
| 41 | MP0004947_skin_inflammation | 1.30807084 |
| 42 | MP0003448_altered_tumor_morphology | 1.26166654 |
| 43 | MP0002277_abnormal_respiratory_mucosa | 1.25220327 |
| 44 | MP0003075_altered_response_to | 1.24115081 |
| 45 | MP0000716_abnormal_immune_system | 1.23962169 |
| 46 | MP0000604_amyloidosis | 1.23378112 |
| 47 | MP0003183_abnormal_peptide_metabolism | 1.22971147 |
| 48 | MP0001542_abnormal_bone_strength | 1.15111381 |
| 49 | MP0003195_calcinosis | 1.11087820 |
| 50 | MP0005248_abnormal_Harderian_gland | 1.10926971 |
| 51 | MP0003172_abnormal_lysosome_physiology | 1.10655927 |
| 52 | MP0003950_abnormal_plasma_membrane | 1.10556382 |
| 53 | MP0002163_abnormal_gland_morphology | 1.09274453 |
| 54 | MP0003787_abnormal_imprinting | 1.06808700 |
| 55 | MP0005623_abnormal_meninges_morphology | 1.06647972 |
| 56 | MP0003763_abnormal_thymus_physiology | 1.05164718 |
| 57 | MP0003091_abnormal_cell_migration | 1.04484017 |
| 58 | MP0002398_abnormal_bone_marrow | 1.01235773 |
| 59 | MP0005084_abnormal_gallbladder_morpholo | 1.00074705 |
| 60 | MP0005166_decreased_susceptibility_to | 0.97965974 |
| 61 | MP0002102_abnormal_ear_morphology | 0.97534588 |
| 62 | MP0000689_abnormal_spleen_morphology | 0.96023047 |
| 63 | MP0008004_abnormal_stomach_pH | 0.94115914 |
| 64 | MP0009763_increased_sensitivity_to | 0.93891277 |
| 65 | MP0010386_abnormal_urinary_bladder | 0.91413936 |
| 66 | MP0002166_altered_tumor_susceptibility | 0.89154246 |
| 67 | MP0001958_emphysema | 0.89025405 |
| 68 | MP0003045_fibrosis | 0.88071840 |
| 69 | MP0003866_abnormal_defecation | 0.87816899 |
| 70 | MP0002722_abnormal_immune_system | 0.81645261 |
| 71 | MP0003633_abnormal_nervous_system | 0.80775829 |
| 72 | MP0001529_abnormal_vocalization | 0.80511402 |
| 73 | MP0002998_abnormal_bone_remodeling | 0.78926549 |
| 74 | MP0008874_decreased_physiological_sensi | 0.78588176 |
| 75 | MP0002693_abnormal_pancreas_physiology | 0.78156801 |
| 76 | MP0002429_abnormal_blood_cell | 0.77632371 |
| 77 | MP0000249_abnormal_blood_vessel | 0.76676450 |
| 78 | MP0000858_altered_metastatic_potential | 0.75638030 |
| 79 | MP0005390_skeleton_phenotype | 0.75577755 |
| 80 | MP0003252_abnormal_bile_duct | 0.74668613 |
| 81 | MP0005535_abnormal_body_temperature | 0.74630320 |
| 82 | MP0005167_abnormal_blood-brain_barrier | 0.73935677 |
| 83 | MP0002006_tumorigenesis | 0.72602551 |
| 84 | MP0005379_endocrine/exocrine_gland_phen | 0.72472924 |
| 85 | MP0000371_diluted_coat_color | 0.72114102 |
| 86 | MP0009765_abnormal_xenobiotic_induced | 0.71185383 |
| 87 | MP0001851_eye_inflammation | 0.70817368 |
| 88 | MP0005376_homeostasis/metabolism_phenot | 0.69561661 |
| 89 | MP0000920_abnormal_myelination | 0.68754474 |
| 90 | MP0003828_pulmonary_edema | 0.68541801 |
| 91 | MP0001853_heart_inflammation | 0.67910165 |
| 92 | MP0003329_amyloid_beta_deposits | 0.67491908 |
| 93 | MP0002168_other_aberrant_phenotype | 0.65646280 |
| 94 | MP0005451_abnormal_body_composition | 0.65424099 |
| 95 | MP0002653_abnormal_ependyma_morphology | 0.64205492 |
| 96 | MP0001501_abnormal_sleep_pattern | 0.63300098 |
| 97 | MP0005266_abnormal_metabolism | 0.63029713 |
| 98 | MP0004142_abnormal_muscle_tone | 0.61927294 |
| 99 | MP0005464_abnormal_platelet_physiology | 0.60706305 |
| 100 | MP0005397_hematopoietic_system_phenotyp | 0.58480487 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Retrobulbar optic neuritis (HP:0100654) | 5.98084890 |
| 2 | Optic neuritis (HP:0100653) | 5.98084890 |
| 3 | Orchitis (HP:0100796) | 5.75396739 |
| 4 | Myositis (HP:0100614) | 5.03826743 |
| 5 | Stomatitis (HP:0010280) | 4.96820020 |
| 6 | Recurrent bacterial skin infections (HP:0005406) | 4.44317910 |
| 7 | Eczematoid dermatitis (HP:0000976) | 4.28433232 |
| 8 | Recurrent abscess formation (HP:0002722) | 4.13439560 |
| 9 | Recurrent cutaneous fungal infections (HP:0011370) | 4.06075424 |
| 10 | Chronic mucocutaneous candidiasis (HP:0002728) | 4.06075424 |
| 11 | Keratoconjunctivitis sicca (HP:0001097) | 4.03681062 |
| 12 | Keratoconjunctivitis (HP:0001096) | 3.87699573 |
| 13 | Abnormality of macrophages (HP:0004311) | 3.85136846 |
| 14 | Recurrent fungal infections (HP:0002841) | 3.71828765 |
| 15 | Abnormality of T cell number (HP:0011839) | 3.57054955 |
| 16 | T lymphocytopenia (HP:0005403) | 3.56998453 |
| 17 | Recurrent skin infections (HP:0001581) | 3.42319793 |
| 18 | Mediastinal lymphadenopathy (HP:0100721) | 3.41575975 |
| 19 | Hemoptysis (HP:0002105) | 3.32751014 |
| 20 | Increased IgM level (HP:0003496) | 3.32382724 |
| 21 | Elevated erythrocyte sedimentation rate (HP:0003565) | 3.30627284 |
| 22 | Pulmonary infiltrates (HP:0002113) | 3.27486462 |
| 23 | Recurrent gram-negative bacterial infections (HP:0005420) | 3.22497728 |
| 24 | Gingivitis (HP:0000230) | 3.07729700 |
| 25 | Vasculitis (HP:0002633) | 3.07138995 |
| 26 | Hypochromic microcytic anemia (HP:0004840) | 2.96547910 |
| 27 | Cheilitis (HP:0100825) | 2.94069092 |
| 28 | Gastrointestinal infarctions (HP:0005244) | 2.93620043 |
| 29 | Encephalitis (HP:0002383) | 2.92983236 |
| 30 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 2.79410824 |
| 31 | Abnormality of liposaccharide metabolism (HP:0010968) | 2.69796818 |
| 32 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 2.69796818 |
| 33 | Abnormality of glycolipid metabolism (HP:0010969) | 2.69796818 |
| 34 | Episodic fever (HP:0001954) | 2.67679169 |
| 35 | Loss of speech (HP:0002371) | 2.60804943 |
| 36 | Joint swelling (HP:0001386) | 2.59648587 |
| 37 | Disinhibition (HP:0000734) | 2.58847904 |
| 38 | Hematochezia (HP:0002573) | 2.55605823 |
| 39 | Vacuolated lymphocytes (HP:0001922) | 2.49219317 |
| 40 | Recurrent viral infections (HP:0004429) | 2.48060158 |
| 41 | Recurrent bronchitis (HP:0002837) | 2.43226783 |
| 42 | Gangrene (HP:0100758) | 2.39921413 |
| 43 | Abnormality of the endocardium (HP:0004306) | 2.34667880 |
| 44 | Interstitial pulmonary disease (HP:0006530) | 2.32752443 |
| 45 | Hypergammaglobulinemia (HP:0010702) | 2.32479635 |
| 46 | Peritonitis (HP:0002586) | 2.31538886 |
| 47 | Chronic otitis media (HP:0000389) | 2.30850162 |
| 48 | Abnormality of the musculature of the pelvis (HP:0001469) | 2.26232825 |
| 49 | Abnormality of the hip-girdle musculature (HP:0001445) | 2.26232825 |
| 50 | Leukocytosis (HP:0001974) | 2.25979130 |
| 51 | Meningitis (HP:0001287) | 2.23246301 |
| 52 | Abnormality of the pleura (HP:0002103) | 2.21706230 |
| 53 | Abnormality of T cells (HP:0002843) | 2.20993337 |
| 54 | Amyotrophic lateral sclerosis (HP:0007354) | 2.17218724 |
| 55 | Keratitis (HP:0000491) | 2.16864681 |
| 56 | Anorexia (HP:0002039) | 2.16564629 |
| 57 | Chronic diarrhea (HP:0002028) | 2.16442228 |
| 58 | Urticaria (HP:0001025) | 2.14984550 |
| 59 | Abnormality of the pericardium (HP:0001697) | 2.09906569 |
| 60 | Arterial thrombosis (HP:0004420) | 2.07147963 |
| 61 | Gingival bleeding (HP:0000225) | 2.04383092 |
| 62 | Eosinophilia (HP:0001880) | 2.02767864 |
| 63 | Mutism (HP:0002300) | 1.98667895 |
| 64 | Inappropriate behavior (HP:0000719) | 1.97022588 |
| 65 | Neoplasm of the tracheobronchial system (HP:0100552) | 1.96557926 |
| 66 | Parakeratosis (HP:0001036) | 1.96119967 |
| 67 | Spontaneous hematomas (HP:0007420) | 1.95452202 |
| 68 | Amyloidosis (HP:0011034) | 1.95022964 |
| 69 | Absent speech (HP:0001344) | 1.92704412 |
| 70 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 1.92604297 |
| 71 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 1.92604297 |
| 72 | Autoimmune hemolytic anemia (HP:0001890) | 1.90476181 |
| 73 | Papilledema (HP:0001085) | 1.88790002 |
| 74 | Excessive salivation (HP:0003781) | 1.87319278 |
| 75 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 1.87225676 |
| 76 | Autoimmune thrombocytopenia (HP:0001973) | 1.86427272 |
| 77 | Albinism (HP:0001022) | 1.85004098 |
| 78 | Absent frontal sinuses (HP:0002688) | 1.84932737 |
| 79 | Progressive inability to walk (HP:0002505) | 1.84845912 |
| 80 | Subacute progressive viral hepatitis (HP:0006572) | 1.84179256 |
| 81 | IgG deficiency (HP:0004315) | 1.83447914 |
| 82 | Abnormality of eosinophils (HP:0001879) | 1.82726057 |
| 83 | Polyneuropathy (HP:0001271) | 1.82002807 |
| 84 | Chest pain (HP:0100749) | 1.79676041 |
| 85 | Memory impairment (HP:0002354) | 1.79381339 |
| 86 | Alveolar cell carcinoma (HP:0006519) | 1.78482767 |
| 87 | IgA deficiency (HP:0002720) | 1.78116630 |
| 88 | Progressive neurologic deterioration (HP:0002344) | 1.77837358 |
| 89 | Pulmonary embolism (HP:0002204) | 1.77206535 |
| 90 | Glomerulopathy (HP:0100820) | 1.77046413 |
| 91 | Pelvic girdle muscle weakness (HP:0003749) | 1.75937738 |
| 92 | Hypochromic anemia (HP:0001931) | 1.74360535 |
| 93 | Abnormality of salivation (HP:0100755) | 1.72839840 |
| 94 | Basal ganglia calcification (HP:0002135) | 1.71175975 |
| 95 | Stomach cancer (HP:0012126) | 1.70827402 |
| 96 | Aplasia/Hypoplasia of the frontal sinuses (HP:0009119) | 1.69183752 |
| 97 | Medulloblastoma (HP:0002885) | 1.68666122 |
| 98 | Lymphopenia (HP:0001888) | 1.68143140 |
| 99 | Abnormality of T cell physiology (HP:0011840) | 1.66598153 |
| 100 | Thyroiditis (HP:0100646) | 1.66198630 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TYK2 | 3.65500136 |
| 2 | EPHA3 | 3.07447347 |
| 3 | GRK7 | 2.84781520 |
| 4 | IKBKE | 2.78198164 |
| 5 | MAP3K14 | 2.67569999 |
| 6 | JAK1 | 2.57007023 |
| 7 | TXK | 2.50520644 |
| 8 | BCR | 2.35345261 |
| 9 | IRAK4 | 2.16121571 |
| 10 | EPHB1 | 2.07922417 |
| 11 | RIPK4 | 2.05709054 |
| 12 | TAOK2 | 2.03518313 |
| 13 | SIK3 | 1.96682597 |
| 14 | BLK | 1.90738778 |
| 15 | CSK | 1.84450268 |
| 16 | CAMKK2 | 1.75355631 |
| 17 | TBK1 | 1.70977226 |
| 18 | MAP4K2 | 1.68928849 |
| 19 | FGFR3 | 1.66232254 |
| 20 | MAP4K1 | 1.58285046 |
| 21 | ERBB3 | 1.52277965 |
| 22 | JAK3 | 1.51320585 |
| 23 | FGR | 1.50663352 |
| 24 | BMPR2 | 1.48830538 |
| 25 | MAP3K4 | 1.46880229 |
| 26 | MAP2K7 | 1.43485755 |
| 27 | CASK | 1.41541803 |
| 28 | TAOK1 | 1.37812503 |
| 29 | MAP3K5 | 1.36327415 |
| 30 | MAP3K3 | 1.35677707 |
| 31 | IRAK1 | 1.31510225 |
| 32 | MAP3K12 | 1.29881454 |
| 33 | JAK2 | 1.29515759 |
| 34 | PAK3 | 1.29038849 |
| 35 | KIT | 1.26078030 |
| 36 | YES1 | 1.25789111 |
| 37 | IKBKB | 1.24241601 |
| 38 | IRAK3 | 1.17370728 |
| 39 | MATK | 1.15506995 |
| 40 | FRK | 1.14019413 |
| 41 | DDR2 | 1.13248449 |
| 42 | ADRBK2 | 1.12556526 |
| 43 | HCK | 1.07977406 |
| 44 | FGFR4 | 1.06742380 |
| 45 | RIPK1 | 1.04906742 |
| 46 | DYRK3 | 1.04841435 |
| 47 | TAOK3 | 1.02539161 |
| 48 | KSR1 | 0.99307662 |
| 49 | MAP2K3 | 0.98182458 |
| 50 | TRIM28 | 0.94323904 |
| 51 | MAP2K4 | 0.93566968 |
| 52 | NEK9 | 0.91091147 |
| 53 | LYN | 0.90702947 |
| 54 | SYK | 0.87054835 |
| 55 | FES | 0.84214447 |
| 56 | IRAK2 | 0.83567955 |
| 57 | PRPF4B | 0.82603982 |
| 58 | CHUK | 0.78055901 |
| 59 | LCK | 0.77148080 |
| 60 | CSNK1G2 | 0.74981952 |
| 61 | MARK1 | 0.74391946 |
| 62 | PTK2B | 0.74223522 |
| 63 | CSNK1A1L | 0.73721525 |
| 64 | TGFBR2 | 0.73523338 |
| 65 | MAP2K6 | 0.72489740 |
| 66 | DYRK1B | 0.72075178 |
| 67 | SIK2 | 0.70325454 |
| 68 | CSNK1G3 | 0.69211250 |
| 69 | MAP3K6 | 0.69182907 |
| 70 | MARK3 | 0.69052889 |
| 71 | ZAP70 | 0.67794360 |
| 72 | FER | 0.66914018 |
| 73 | SGK2 | 0.65362830 |
| 74 | MAPK13 | 0.62572770 |
| 75 | NLK | 0.61066365 |
| 76 | BTK | 0.58894324 |
| 77 | PRKD2 | 0.58620679 |
| 78 | CSNK1G1 | 0.55348778 |
| 79 | HIPK2 | 0.54799988 |
| 80 | EGFR | 0.54012680 |
| 81 | WNK3 | 0.53430827 |
| 82 | PIM2 | 0.52527024 |
| 83 | PRKCE | 0.51411387 |
| 84 | MAP3K1 | 0.50518561 |
| 85 | MOS | 0.47300972 |
| 86 | DYRK1A | 0.46988772 |
| 87 | MAP3K2 | 0.46520197 |
| 88 | PDGFRB | 0.45264670 |
| 89 | PINK1 | 0.45023756 |
| 90 | ABL1 | 0.44067442 |
| 91 | CSF1R | 0.43564676 |
| 92 | MAPK7 | 0.43172264 |
| 93 | PRKCQ | 0.43003763 |
| 94 | STK24 | 0.42018035 |
| 95 | TEC | 0.40498837 |
| 96 | SGK3 | 0.40298622 |
| 97 | STK38 | 0.38835232 |
| 98 | INSR | 0.38549859 |
| 99 | GRK6 | 0.38399273 |
| 100 | FYN | 0.38055706 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 2.83401115 |
| 2 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 2.81729490 |
| 3 | Osteoclast differentiation_Homo sapiens_hsa04380 | 2.72672781 |
| 4 | Measles_Homo sapiens_hsa05162 | 2.67579358 |
| 5 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 2.31389746 |
| 6 | Allograft rejection_Homo sapiens_hsa05330 | 2.24042914 |
| 7 | Leishmaniasis_Homo sapiens_hsa05140 | 2.22770608 |
| 8 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 2.19492082 |
| 9 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.18637168 |
| 10 | Influenza A_Homo sapiens_hsa05164 | 2.04885045 |
| 11 | TNF signaling pathway_Homo sapiens_hsa04668 | 1.98553871 |
| 12 | Malaria_Homo sapiens_hsa05144 | 1.97902968 |
| 13 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.93554385 |
| 14 | Tuberculosis_Homo sapiens_hsa05152 | 1.90632567 |
| 15 | African trypanosomiasis_Homo sapiens_hsa05143 | 1.88072197 |
| 16 | Legionellosis_Homo sapiens_hsa05134 | 1.86658922 |
| 17 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.82891846 |
| 18 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.81012314 |
| 19 | Hepatitis C_Homo sapiens_hsa05160 | 1.80850352 |
| 20 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.80593254 |
| 21 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.75814439 |
| 22 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.73838037 |
| 23 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.72228428 |
| 24 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.66347196 |
| 25 | Pertussis_Homo sapiens_hsa05133 | 1.64325777 |
| 26 | Phagosome_Homo sapiens_hsa04145 | 1.61375394 |
| 27 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.59550886 |
| 28 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 1.56391141 |
| 29 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.56205648 |
| 30 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.54256610 |
| 31 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.51967118 |
| 32 | Hepatitis B_Homo sapiens_hsa05161 | 1.50750634 |
| 33 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.45998266 |
| 34 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 1.45115661 |
| 35 | Salmonella infection_Homo sapiens_hsa05132 | 1.34506093 |
| 36 | Shigellosis_Homo sapiens_hsa05131 | 1.25373267 |
| 37 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.19310183 |
| 38 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.19065152 |
| 39 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.17354387 |
| 40 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.14999002 |
| 41 | Viral myocarditis_Homo sapiens_hsa05416 | 1.14798584 |
| 42 | Asthma_Homo sapiens_hsa05310 | 1.13497046 |
| 43 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 1.10914993 |
| 44 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 1.09397792 |
| 45 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.01077122 |
| 46 | Lysosome_Homo sapiens_hsa04142 | 0.98332731 |
| 47 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.97649822 |
| 48 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.95030255 |
| 49 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.93399754 |
| 50 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.91524389 |
| 51 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.81580370 |
| 52 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.81263505 |
| 53 | Apoptosis_Homo sapiens_hsa04210 | 0.79769273 |
| 54 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.79601270 |
| 55 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.76015313 |
| 56 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.75865832 |
| 57 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.75669087 |
| 58 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.69594438 |
| 59 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.68954976 |
| 60 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.68437742 |
| 61 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.66520864 |
| 62 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.61845533 |
| 63 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.61737736 |
| 64 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.60547044 |
| 65 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.59640828 |
| 66 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.57893954 |
| 67 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.53489933 |
| 68 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.51238274 |
| 69 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.51161916 |
| 70 | Endocytosis_Homo sapiens_hsa04144 | 0.50630326 |
| 71 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.48879126 |
| 72 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.47738039 |
| 73 | Other glycan degradation_Homo sapiens_hsa00511 | 0.47310963 |
| 74 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.46898329 |
| 75 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.46140929 |
| 76 | Circadian rhythm_Homo sapiens_hsa04710 | 0.45847669 |
| 77 | Amoebiasis_Homo sapiens_hsa05146 | 0.42206257 |
| 78 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.41704219 |
| 79 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.36353239 |
| 80 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.36237006 |
| 81 | Platelet activation_Homo sapiens_hsa04611 | 0.34973165 |
| 82 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.34846947 |
| 83 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.34038345 |
| 84 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.32402390 |
| 85 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.29812090 |
| 86 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.29304959 |
| 87 | Cocaine addiction_Homo sapiens_hsa05030 | 0.29259119 |
| 88 | Protein export_Homo sapiens_hsa03060 | 0.29258030 |
| 89 | Insulin resistance_Homo sapiens_hsa04931 | 0.28884703 |
| 90 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.28844407 |
| 91 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.28081169 |
| 92 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.27655036 |
| 93 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.26314807 |
| 94 | GABAergic synapse_Homo sapiens_hsa04727 | 0.24823934 |
| 95 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.24142689 |
| 96 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.22965646 |
| 97 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.20417122 |
| 98 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.20371670 |
| 99 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.19802701 |
| 100 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.19720867 |

