ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	nucleobase catabolic process (GO:0046113)	8.22262780
2	presynaptic membrane assembly (GO:0097105)	6.39196056
3	presynaptic membrane organization (GO:0097090)	6.00540510
4	glycosphingolipid biosynthetic process (GO:0006688)	5.71287705
5	olfactory bulb development (GO:0021772)	5.59280268
6	limb bud formation (GO:0060174)	5.37614980
7	cell migration in hindbrain (GO:0021535)	5.23133325
8	neural tube formation (GO:0001841)	5.11222778
9	central nervous system projection neuron axonogenesis (GO:0021952)	4.72898326
10	negative regulation of oligodendrocyte differentiation (GO:0048715)	4.60664708
11	vocalization behavior (GO:0071625)	4.41169198
12	brain morphogenesis (GO:0048854)	4.29281918
13	cerebral cortex cell migration (GO:0021795)	4.24430014
14	opioid receptor signaling pathway (GO:0038003)	4.18084303
15	startle response (GO:0001964)	4.17558553
16	central nervous system neuron axonogenesis (GO:0021955)	4.17141869
17	sialylation (GO:0097503)	4.17032978
18	sympathetic nervous system development (GO:0048485)	4.15951885
19	cerebral cortex radially oriented cell migration (GO:0021799)	4.15371279
20	regulation of short-term neuronal synaptic plasticity (GO:0048172)	4.12324320
21	regulation of collateral sprouting (GO:0048670)	4.10682982
22	negative regulation of dendrite development (GO:2000171)	3.86988557
23	retinal ganglion cell axon guidance (GO:0031290)	3.82082029
24	neuron recognition (GO:0008038)	3.79487458
25	keratinocyte development (GO:0003334)	3.77115585
26	neuron cell-cell adhesion (GO:0007158)	3.73742583
27	negative regulation of axon extension involved in axon guidance (GO:0048843)	3.67922989
28	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.66299518
29	synaptic vesicle maturation (GO:0016188)	3.52662052
30	adaptation of signaling pathway (GO:0023058)	3.51102756
31	cardiac ventricle formation (GO:0003211)	3.50646165
32	detection of light stimulus involved in visual perception (GO:0050908)	3.49257828
33	detection of light stimulus involved in sensory perception (GO:0050962)	3.49257828
34	hippocampus development (GO:0021766)	3.45162582
35	protein localization to cilium (GO:0061512)	3.41212863
36	dendrite morphogenesis (GO:0048813)	3.40917373
37	inositol phosphate catabolic process (GO:0071545)	3.38381592
38	innervation (GO:0060384)	3.37761557
39	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.37287431
40	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.37287431
41	regulation of translation, ncRNA-mediated (GO:0045974)	3.37287431
42	negative regulation of neurological system process (GO:0031645)	3.32674913
43	intraciliary transport (GO:0042073)	3.29962412
44	positive regulation of synapse assembly (GO:0051965)	3.29851518
45	forebrain neuron differentiation (GO:0021879)	3.27849165
46	glial cell proliferation (GO:0014009)	3.24847050
47	negative regulation of axon guidance (GO:1902668)	3.23557188
48	prenylation (GO:0097354)	3.20277852
49	protein prenylation (GO:0018342)	3.20277852
50	cardiac chamber formation (GO:0003207)	3.19815593
51	positive regulation of amino acid transport (GO:0051957)	3.19573021
52	gamma-aminobutyric acid transport (GO:0015812)	3.18664261
53	negative regulation of microtubule depolymerization (GO:0007026)	3.18274078
54	regulation of secondary heart field cardioblast proliferation (GO:0003266)	3.18149463
55	regulation of cardioblast proliferation (GO:0003264)	3.18149463
56	histone H2A acetylation (GO:0043968)	3.18079645
57	regulation of cilium movement (GO:0003352)	3.13667776
58	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.13517486
59	response to pheromone (GO:0019236)	3.12039406
60	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.12022212
61	cerebral cortex neuron differentiation (GO:0021895)	3.05216708
62	establishment of mitochondrion localization (GO:0051654)	3.04090662
63	protein localization to microtubule cytoskeleton (GO:0072698)	3.03688842
64	forebrain neuron development (GO:0021884)	3.03637695
65	regulation of microtubule depolymerization (GO:0031114)	3.03350193
66	regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)	3.03277637
67	ectoderm development (GO:0007398)	2.95793082
68	primary amino compound metabolic process (GO:1901160)	2.92042627
69	microtubule depolymerization (GO:0007019)	2.91735660
70	regulation of synapse structural plasticity (GO:0051823)	2.90395650
71	regulation of synapse assembly (GO:0051963)	2.90200664
72	telencephalon cell migration (GO:0022029)	2.87065457
73	regulation of telomere maintenance (GO:0032204)	2.85747453
74	indolalkylamine metabolic process (GO:0006586)	2.84057735
75	reflex (GO:0060004)	2.83883050
76	spinal cord development (GO:0021510)	2.83597142
77	righting reflex (GO:0060013)	2.83573413
78	regulation of timing of cell differentiation (GO:0048505)	2.82431132
79	regulation of pigment cell differentiation (GO:0050932)	2.80711668
80	positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)	2.80076573
81	protein polyglutamylation (GO:0018095)	2.79284691
82	hindbrain development (GO:0030902)	2.79196069
83	regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)	2.77346814
84	regulation of axon extension involved in axon guidance (GO:0048841)	2.76807597
85	carnitine metabolic process (GO:0009437)	2.75949785
86	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	2.74604008
87	serotonin metabolic process (GO:0042428)	2.71185492
88	regulation of oligodendrocyte differentiation (GO:0048713)	2.70966636
89	positive regulation of developmental pigmentation (GO:0048087)	2.70283102
90	pyrimidine-containing compound catabolic process (GO:0072529)	2.69028924
91	DNA damage response, detection of DNA damage (GO:0042769)	2.65954074
92	centrosome duplication (GO:0051298)	2.65349579
93	protein localization to cytoskeleton (GO:0044380)	2.64320375
94	negative regulation of microtubule polymerization or depolymerization (GO:0031111)	2.63830312
95	ganglion development (GO:0061548)	2.62741873
96	forebrain cell migration (GO:0021885)	2.62590685
97	cell wall macromolecule catabolic process (GO:0016998)	2.61913284
98	ubiquinone metabolic process (GO:0006743)	2.59228096
99	regulation of axon guidance (GO:1902667)	2.58819772
100	pyrimidine nucleobase catabolic process (GO:0006208)	10.1805435

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IGF1R_20145208_ChIP-Seq_DFB_Human	3.88245694
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.86892705
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.85830717
4	ZFP57_27257070_Chip-Seq_ESCs_Mouse	3.26249365
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.11659544
6	VDR_22108803_ChIP-Seq_LS180_Human	2.81674381
7	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.62950063
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.58130669
9	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	2.40025474
10	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.36301620
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.35235014
12	ZNF274_21170338_ChIP-Seq_K562_Hela	2.32673684
13	EZH2_22144423_ChIP-Seq_EOC_Human	2.27816509
14	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.25364848
15	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.24765854
16	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.22949392
17	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.00778073
18	EWS_26573619_Chip-Seq_HEK293_Human	1.94991908
19	P300_19829295_ChIP-Seq_ESCs_Human	1.94407510
20	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.92632917
21	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.92517870
22	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.91633150
23	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.87176906
24	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.85727667
25	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.79326810
26	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.78128967
27	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.75653057
28	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.74322910
29	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.74195160
30	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.72005607
31	TAF15_26573619_Chip-Seq_HEK293_Human	1.70379001
32	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.66450293
33	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.64453194
34	REST_21632747_ChIP-Seq_MESCs_Mouse	1.63147053
35	AR_21572438_ChIP-Seq_LNCaP_Human	1.63098451
36	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.60314974
37	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.60121858
38	SMAD4_21799915_ChIP-Seq_A2780_Human	1.59557997
39	FUS_26573619_Chip-Seq_HEK293_Human	1.59284405
40	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.58423210
41	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.52685267
42	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.50837696
43	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.50074821
44	JUN_21703547_ChIP-Seq_K562_Human	1.48601406
45	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.48558064
46	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.45867796
47	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.45399090
48	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.44336760
49	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.41967738
50	STAT3_23295773_ChIP-Seq_U87_Human	1.40150787
51	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.39923301
52	CBP_20019798_ChIP-Seq_JUKART_Human	1.38949964
53	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.38949964
54	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.35560914
55	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.33942165
56	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.33330150
57	AR_25329375_ChIP-Seq_VCAP_Human	1.32883539
58	TCF4_23295773_ChIP-Seq_U87_Human	1.32694358
59	RNF2_27304074_Chip-Seq_NSC_Mouse	1.31927354
60	SOX9_26525672_Chip-Seq_HEART_Mouse	1.30805238
61	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.30466978
62	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.30382913
63	P53_22387025_ChIP-Seq_ESCs_Mouse	1.30313005
64	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.28469169
65	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.27958244
66	TCF4_22108803_ChIP-Seq_LS180_Human	1.27872416
67	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.26602051
68	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.24668157
69	TP53_22573176_ChIP-Seq_HFKS_Human	1.22529031
70	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.22385363
71	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.22385363
72	ER_23166858_ChIP-Seq_MCF-7_Human	1.20793693
73	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.18899871
74	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.18610198
75	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.17149105
76	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.15775438
77	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.15634323
78	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.13845550
79	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	1.13247688
80	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.12373650
81	RUNX2_22187159_ChIP-Seq_PCA_Human	1.11296623
82	EGR1_19032775_ChIP-ChIP_M12_Human	1.09328403
83	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.08296736
84	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.07989756
85	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.07702976
86	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.07587853
87	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.07311191
88	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.06784604
89	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.06027130
90	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.06017834
91	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.05859812
92	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.04761691
93	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.04258670
94	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.04009245
95	TBL1_22424771_ChIP-Seq_293T_Human	1.02025957
96	TP53_18474530_ChIP-ChIP_U2OS_Human	1.01121435
97	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.00757636
98	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.00682237
99	BCAT_22108803_ChIP-Seq_LS180_Human	1.00143704
100	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.99775554

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	3.06621048
2	MP0006054_spinal_hemorrhage	2.98199309
3	MP0004147_increased_porphyrin_level	2.95387953
4	MP0002751_abnormal_autonomic_nervous	2.94357922
5	MP0002736_abnormal_nociception_after	2.85767673
6	MP0008789_abnormal_olfactory_epithelium	2.84494441
7	MP0003011_delayed_dark_adaptation	2.78710604
8	MP0000778_abnormal_nervous_system	2.75843401
9	MP0003283_abnormal_digestive_organ	2.64645452
10	MP0000516_abnormal_urinary_system	2.64465500
11	MP0005367_renal/urinary_system_phenotyp	2.64465500
12	MP0000372_irregular_coat_pigmentation	2.64133887
13	MP0005394_taste/olfaction_phenotype	2.52746277
14	MP0005499_abnormal_olfactory_system	2.52746277
15	MP0001529_abnormal_vocalization	2.46186561
16	MP0004270_analgesia	2.30032949
17	MP0009046_muscle_twitch	2.20778769
18	MP0000049_abnormal_middle_ear	2.18642749
19	MP0001984_abnormal_olfaction	2.15582843
20	MP0001968_abnormal_touch/_nociception	2.14489724
21	MP0005503_abnormal_tendon_morphology	2.13127202
22	MP0005253_abnormal_eye_physiology	2.07624434
23	MP0006072_abnormal_retinal_apoptosis	1.97568216
24	MP0003195_calcinosis	1.94835080
25	MP0003635_abnormal_synaptic_transmissio	1.93450387
26	MP0005551_abnormal_eye_electrophysiolog	1.91516349
27	MP0003122_maternal_imprinting	1.85638050
28	MP0002063_abnormal_learning/memory/cond	1.81647185
29	MP0001486_abnormal_startle_reflex	1.77749365
30	MP0003121_genomic_imprinting	1.66420992
31	MP0004742_abnormal_vestibular_system	1.61830499
32	MP0002102_abnormal_ear_morphology	1.59901828
33	MP0008995_early_reproductive_senescence	1.59334806
34	MP0003787_abnormal_imprinting	1.57184162
35	MP0004811_abnormal_neuron_physiology	1.54806707
36	MP0005171_absent_coat_pigmentation	1.53915608
37	MP0002184_abnormal_innervation	1.46414088
38	MP0002557_abnormal_social/conspecific_i	1.43845990
39	MP0002735_abnormal_chemical_nociception	1.40574520
40	MP0006276_abnormal_autonomic_nervous	1.40454097
41	MP0005187_abnormal_penis_morphology	1.39414466
42	MP0005275_abnormal_skin_tensile	1.38879462
43	MP0002882_abnormal_neuron_morphology	1.36870160
44	MP0004142_abnormal_muscle_tone	1.35467885
45	MP0002572_abnormal_emotion/affect_behav	1.33142132
46	MP0006292_abnormal_olfactory_placode	1.31870944
47	MP0000955_abnormal_spinal_cord	1.31461304
48	MP0005083_abnormal_biliary_tract	1.31199363
49	MP0004134_abnormal_chest_morphology	1.28140018
50	MP0008058_abnormal_DNA_repair	1.27273992
51	MP0002734_abnormal_mechanical_nocicepti	1.24068937
52	MP0002064_seizures	1.22896994
53	MP0004883_abnormal_blood_vessel	1.17254871
54	MP0002067_abnormal_sensory_capabilities	1.16126679
55	MP0002272_abnormal_nervous_system	1.16030029
56	MP0005386_behavior/neurological_phenoty	1.13703993
57	MP0004924_abnormal_behavior	1.13703993
58	MP0003755_abnormal_palate_morphology	1.13458081
59	MP0002752_abnormal_somatic_nervous	1.11105927
60	MP0001502_abnormal_circadian_rhythm	1.11074804
61	MP0000647_abnormal_sebaceous_gland	1.10138623
62	MP0003935_abnormal_craniofacial_develop	1.10099852
63	MP0009745_abnormal_behavioral_response	1.09291329
64	MP0005623_abnormal_meninges_morphology	1.09020932
65	MP0004859_abnormal_synaptic_plasticity	1.08759531
66	MP0003861_abnormal_nervous_system	1.06588768
67	MP0001270_distended_abdomen	1.02464244
68	MP0003329_amyloid_beta_deposits	1.01970623
69	MP0000631_abnormal_neuroendocrine_gland	1.00564321
70	MP0002152_abnormal_brain_morphology	1.00064904
71	MP0003938_abnormal_ear_development	0.99193819
72	MP0005646_abnormal_pituitary_gland	0.96380801
73	MP0003718_maternal_effect	0.96115959
74	MP0000427_abnormal_hair_cycle	0.95972965
75	MP0001905_abnormal_dopamine_level	0.94769072
76	MP0002233_abnormal_nose_morphology	0.94246572
77	MP0005085_abnormal_gallbladder_physiolo	0.93978753
78	MP0001501_abnormal_sleep_pattern	0.92560290
79	MP0003119_abnormal_digestive_system	0.90687427
80	MP0008877_abnormal_DNA_methylation	0.90157581
81	MP0001188_hyperpigmentation	0.89640667
82	MP0009250_abnormal_appendicular_skeleto	0.89296750
83	MP0001970_abnormal_pain_threshold	0.89030838
84	MP0001177_atelectasis	0.83976080
85	MP0005257_abnormal_intraocular_pressure	0.80879098
86	MP0005084_abnormal_gallbladder_morpholo	0.80799285
87	MP0003698_abnormal_male_reproductive	0.79831587
88	MP0000026_abnormal_inner_ear	0.79071620
89	MP0003656_abnormal_erythrocyte_physiolo	0.75886235
90	MP0002066_abnormal_motor_capabilities/c	0.75795562
91	MP0009384_cardiac_valve_regurgitation	0.72680876
92	MP0000537_abnormal_urethra_morphology	0.72564017
93	MP0008872_abnormal_physiological_respon	0.72004551
94	MP0005391_vision/eye_phenotype	0.71665571
95	MP0001348_abnormal_lacrimal_gland	0.71274534
96	MP0003937_abnormal_limbs/digits/tail_de	0.71079927
97	MP0002069_abnormal_eating/drinking_beha	0.68713176
98	MP0008873_increased_physiological_sensi	0.68311567
99	MP0001986_abnormal_taste_sensitivity	0.66410664
100	MP0004215_abnormal_myocardial_fiber	0.66325963

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypoplastic pelvis (HP:0008839)	6.42246589
2	Retinal dysplasia (HP:0007973)	5.38692628
3	Absent speech (HP:0001344)	4.26222671
4	Chronic hepatic failure (HP:0100626)	3.89394697
5	Amyotrophic lateral sclerosis (HP:0007354)	3.73226776
6	Action tremor (HP:0002345)	3.62091494
7	Hyperventilation (HP:0002883)	3.53305603
8	Tubulointerstitial nephritis (HP:0001970)	3.52485263
9	Diminished motivation (HP:0000745)	3.23549182
10	Polyphagia (HP:0002591)	3.09280930
11	Broad distal phalanx of finger (HP:0009836)	3.05586760
12	Small epiphyses (HP:0010585)	3.05566932
13	Tented upper lip vermilion (HP:0010804)	3.01767966
14	Vaginal atresia (HP:0000148)	2.99778797
15	Genital tract atresia (HP:0001827)	2.98475282
16	Progressive cerebellar ataxia (HP:0002073)	2.97515869
17	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	2.97418750
18	Split foot (HP:0001839)	2.97028815
19	Abnormality of midbrain morphology (HP:0002418)	2.91053010
20	Molar tooth sign on MRI (HP:0002419)	2.91053010
21	Apathy (HP:0000741)	2.89555867
22	Lissencephaly (HP:0001339)	2.86676348
23	Drooling (HP:0002307)	2.85681917
24	Delusions (HP:0000746)	2.76602366
25	Patellar aplasia (HP:0006443)	2.64521345
26	Excessive salivation (HP:0003781)	2.64215798
27	Type II lissencephaly (HP:0007260)	2.61229866
28	Aplasia/Hypoplasia of the 5th finger (HP:0006262)	2.61181523
29	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.60836931
30	Pancreatic cysts (HP:0001737)	2.55178628
31	Hypoplasia of the brainstem (HP:0002365)	2.54828829
32	Aplasia/Hypoplasia of the brainstem (HP:0007362)	2.54828829
33	Focal seizures (HP:0007359)	2.48778607
34	Focal motor seizures (HP:0011153)	2.48577802
35	Gaze-evoked nystagmus (HP:0000640)	2.48313360
36	Aplasia/Hypoplasia of the patella (HP:0006498)	2.47383757
37	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.45171047
38	Inappropriate behavior (HP:0000719)	2.44169305
39	Carpal bone hypoplasia (HP:0001498)	2.44163008
40	Bifid tongue (HP:0010297)	2.43462622
41	Irregular vertebral endplates (HP:0003301)	2.43056152
42	Cutaneous finger syndactyly (HP:0010554)	2.42047045
43	Pachygyria (HP:0001302)	2.40413879
44	Progressive inability to walk (HP:0002505)	2.39797476
45	Myokymia (HP:0002411)	2.33771863
46	Stomach cancer (HP:0012126)	2.32685338
47	Volvulus (HP:0002580)	2.30854810
48	Small hand (HP:0200055)	2.28670156
49	Esotropia (HP:0000565)	2.27089863
50	Cupped ear (HP:0000378)	2.24701483
51	Disinhibition (HP:0000734)	2.24507418
52	Neonatal respiratory distress (HP:0002643)	2.22218097
53	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.20683465
54	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.19462041
55	Short foot (HP:0001773)	2.17479927
56	Abnormality of the pancreatic islet cells (HP:0006476)	2.16431275
57	Abnormality of endocrine pancreas physiology (HP:0012093)	2.16431275
58	Pancreatic islet-cell hyperplasia (HP:0004510)	2.16156370
59	Nephronophthisis (HP:0000090)	2.14948245
60	Gait imbalance (HP:0002141)	2.13065009
61	Barrel-shaped chest (HP:0001552)	2.12123667
62	Cutaneous syndactyly (HP:0012725)	2.11304821
63	Renal hypoplasia (HP:0000089)	2.10659944
64	Pancreatic fibrosis (HP:0100732)	2.10496919
65	True hermaphroditism (HP:0010459)	2.08750045
66	Abnormality of the pubic bones (HP:0003172)	2.06502083
67	Medial flaring of the eyebrow (HP:0010747)	2.06200664
68	Sensorimotor neuropathy (HP:0007141)	1.98191480
69	Abnormal rod and cone electroretinograms (HP:0008323)	1.96742657
70	Short 5th finger (HP:0009237)	1.95064188
71	Abnormality of the labia minora (HP:0012880)	1.93475472
72	Abnormal lung lobation (HP:0002101)	1.92932318
73	Dysdiadochokinesis (HP:0002075)	1.92743691
74	Congenital primary aphakia (HP:0007707)	1.91776809
75	Sclerocornea (HP:0000647)	1.91677944
76	Limb dystonia (HP:0002451)	1.91017265
77	Fibular aplasia (HP:0002990)	1.89958353
78	Skull defect (HP:0001362)	1.89219316
79	Congenital stationary night blindness (HP:0007642)	1.88335737
80	Polymicrogyria (HP:0002126)	1.87572248
81	Vitreoretinal degeneration (HP:0000655)	1.85733439
82	Morphological abnormality of the middle ear (HP:0008609)	1.85619716
83	Absent eyebrow (HP:0002223)	1.83556967
84	Intellectual disability, moderate (HP:0002342)	1.82845912
85	Nephrogenic diabetes insipidus (HP:0009806)	1.79940544
86	Attenuation of retinal blood vessels (HP:0007843)	1.79360431
87	Dyskinesia (HP:0100660)	1.79330167
88	Submucous cleft hard palate (HP:0000176)	1.78356145
89	Cortical dysplasia (HP:0002539)	1.78343682
90	Abolished electroretinogram (ERG) (HP:0000550)	1.77369704
91	Specific learning disability (HP:0001328)	1.76475834
92	Abnormality of the vertebral endplates (HP:0005106)	1.75240772
93	Protruding tongue (HP:0010808)	1.73816312
94	Metaphyseal cupping (HP:0003021)	1.73735425
95	High anterior hairline (HP:0009890)	1.73541014
96	Decreased central vision (HP:0007663)	1.72148209
97	Inability to walk (HP:0002540)	1.71477797
98	Adactyly (HP:0009776)	1.71377084
99	Abnormality of the lower motor neuron (HP:0002366)	1.70939019
100	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.70507990

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	7.91115511
2	MARK1	4.37045479
3	FRK	4.12572446
4	MAP2K7	2.82315183
5	CASK	2.73457808
6	EPHA4	2.47982884
7	MAP3K4	2.40833170
8	EIF2AK3	2.40626736
9	WNK3	2.35424761
10	BCR	2.20616445
11	GRK7	1.96740782
12	ACVR1B	1.93899338
13	DYRK2	1.88554312
14	MAPK13	1.88195534
15	MKNK2	1.86232072
16	SRPK1	1.83119770
17	BMPR1B	1.76318581
18	PAK3	1.76308120
19	ZAK	1.74809295
20	TRIM28	1.73555992
21	EPHA3	1.61416988
22	MKNK1	1.43331877
23	FGFR2	1.41506077
24	PAK6	1.39400756
25	TNIK	1.29295257
26	TAOK1	1.18128368
27	NUAK1	1.14071972
28	KSR1	1.13535483
29	YES1	1.05044942
30	DYRK1A	1.00951612
31	PLK3	0.96820682
32	PKN1	0.95664258
33	ADRBK1	0.93312815
34	MAP2K4	0.90707768
35	WEE1	0.90074585
36	CDC7	0.86269232
37	RAF1	0.84840628
38	MINK1	0.82636195
39	DAPK2	0.78507121
40	PRKCG	0.77296889
41	CSNK1D	0.76261243
42	CSNK1G1	0.76110645
43	CSNK1G3	0.73907232
44	PRKCZ	0.73403025
45	PLK1	0.71375181
46	CSNK1A1L	0.70797481
47	CSNK1G2	0.68566003
48	SIK3	0.68226475
49	PRKCE	0.67335606
50	EPHB2	0.65890106
51	GRK5	0.65151816
52	STK16	0.63692091
53	TNK2	0.62628957
54	ADRBK2	0.62581651
55	CDK5	0.61892097
56	PLK2	0.60730947
57	STK24	0.60426762
58	DMPK	0.60411762
59	INSRR	0.55967242
60	ERBB2	0.55907120
61	PRKAA1	0.52618611
62	CAMK4	0.51799388
63	TGFBR1	0.51577283
64	NTRK2	0.51470824
65	PTK2B	0.50732346
66	MATK	0.48796291
67	PLK4	0.48370147
68	SGK2	0.47775629
69	CSNK1A1	0.46542727
70	CAMK1	0.46368065
71	PHKG1	0.43358597
72	PHKG2	0.43358597
73	NEK1	0.43128461
74	RPS6KB1	0.39952296
75	PKN2	0.39639064
76	GRK1	0.37812650
77	MAPK8	0.36767969
78	SIK2	0.36742204
79	ERBB3	0.36398410
80	ATR	0.34955149
81	CLK1	0.34762732
82	CAMK2A	0.34276552
83	CAMKK2	0.34093380
84	PRKACA	0.32641161
85	PRKG1	0.30119653
86	EGFR	0.29954539
87	SGK223	0.28952547
88	SGK494	0.28952547
89	AURKB	0.28748479
90	OBSCN	0.28733022
91	VRK1	0.27858974
92	ATM	0.27667684
93	PRKACG	0.26929040
94	DYRK3	0.26448444
95	CDK14	0.26016664
96	PRKACB	0.25897878
97	SYK	0.25257135
98	BUB1	0.23521837
99	CDK18	0.23323683
100	PRKCA	0.23309679

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	6.90440176
2	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.14450231
3	Phototransduction_Homo sapiens_hsa04744	2.85833988
4	Nicotine addiction_Homo sapiens_hsa05033	2.71523201
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.35634352
6	Non-homologous end-joining_Homo sapiens_hsa03450	2.21326814
7	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.02400628
8	Butanoate metabolism_Homo sapiens_hsa00650	2.01128541
9	Axon guidance_Homo sapiens_hsa04360	2.00827175
10	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.97779084
11	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.95619858
12	GABAergic synapse_Homo sapiens_hsa04727	1.88629215
13	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.86916671
14	Gap junction_Homo sapiens_hsa04540	1.81181244
15	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.79156257
16	Caffeine metabolism_Homo sapiens_hsa00232	1.78895789
17	Circadian entrainment_Homo sapiens_hsa04713	1.71969871
18	Morphine addiction_Homo sapiens_hsa05032	1.69499955
19	Glutamatergic synapse_Homo sapiens_hsa04724	1.53218857
20	Oocyte meiosis_Homo sapiens_hsa04114	1.52348850
21	Dopaminergic synapse_Homo sapiens_hsa04728	1.52118252
22	Fanconi anemia pathway_Homo sapiens_hsa03460	1.44670352
23	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.42441402
24	Ether lipid metabolism_Homo sapiens_hsa00565	1.36897345
25	Long-term depression_Homo sapiens_hsa04730	1.36868530
26	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.32051930
27	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.28555252
28	Circadian rhythm_Homo sapiens_hsa04710	1.26830903
29	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.20848230
30	African trypanosomiasis_Homo sapiens_hsa05143	1.17914299
31	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.16677512
32	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.14174323
33	Olfactory transduction_Homo sapiens_hsa04740	1.09422380
34	Salivary secretion_Homo sapiens_hsa04970	1.08441242
35	Regulation of autophagy_Homo sapiens_hsa04140	0.90818535
36	Taste transduction_Homo sapiens_hsa04742	0.89166900
37	Linoleic acid metabolism_Homo sapiens_hsa00591	0.86821349
38	Chemical carcinogenesis_Homo sapiens_hsa05204	0.86550496
39	Collecting duct acid secretion_Homo sapiens_hsa04966	0.82069508
40	Retinol metabolism_Homo sapiens_hsa00830	0.81840716
41	Peroxisome_Homo sapiens_hsa04146	0.81687106
42	Hippo signaling pathway_Homo sapiens_hsa04390	0.79223016
43	Insulin secretion_Homo sapiens_hsa04911	0.76023230
44	AMPK signaling pathway_Homo sapiens_hsa04152	0.75426021
45	Amphetamine addiction_Homo sapiens_hsa05031	0.75098967
46	Melanogenesis_Homo sapiens_hsa04916	0.71625530
47	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.70144890
48	Endometrial cancer_Homo sapiens_hsa05213	0.67180253
49	Tryptophan metabolism_Homo sapiens_hsa00380	0.66375624
50	Protein export_Homo sapiens_hsa03060	0.64580407
51	Serotonergic synapse_Homo sapiens_hsa04726	0.64467530
52	Steroid biosynthesis_Homo sapiens_hsa00100	0.63710794
53	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.63691009
54	RNA degradation_Homo sapiens_hsa03018	0.62901325
55	Cholinergic synapse_Homo sapiens_hsa04725	0.62337188
56	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.60796460
57	mRNA surveillance pathway_Homo sapiens_hsa03015	0.60208365
58	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.58615566
59	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.56632953
60	Wnt signaling pathway_Homo sapiens_hsa04310	0.54584115
61	Calcium signaling pathway_Homo sapiens_hsa04020	0.53848797
62	Fatty acid metabolism_Homo sapiens_hsa01212	0.52457281
63	Cocaine addiction_Homo sapiens_hsa05030	0.52290989
64	Pertussis_Homo sapiens_hsa05133	0.49723679
65	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.47979518
66	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.47749012
67	Long-term potentiation_Homo sapiens_hsa04720	0.47050245
68	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.46910247
69	Propanoate metabolism_Homo sapiens_hsa00640	0.46198090
70	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.45548928
71	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.44549001
72	MicroRNAs in cancer_Homo sapiens_hsa05206	0.44379998
73	FoxO signaling pathway_Homo sapiens_hsa04068	0.43384428
74	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.43249646
75	Ras signaling pathway_Homo sapiens_hsa04014	0.42406936
76	Homologous recombination_Homo sapiens_hsa03440	0.42150777
77	beta-Alanine metabolism_Homo sapiens_hsa00410	0.41343345
78	Alcoholism_Homo sapiens_hsa05034	0.41227782
79	Basal cell carcinoma_Homo sapiens_hsa05217	0.40610108
80	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.39007110
81	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.38093868
82	Basal transcription factors_Homo sapiens_hsa03022	0.37560643
83	Phagosome_Homo sapiens_hsa04145	0.36217680
84	Gastric acid secretion_Homo sapiens_hsa04971	0.35262033
85	Nitrogen metabolism_Homo sapiens_hsa00910	0.33966671
86	Selenocompound metabolism_Homo sapiens_hsa00450	0.33371640
87	Renin-angiotensin system_Homo sapiens_hsa04614	0.31681705
88	Colorectal cancer_Homo sapiens_hsa05210	0.31177763
89	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.30658567
90	cAMP signaling pathway_Homo sapiens_hsa04024	0.30105292
91	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.28603755
92	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.28271071
93	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.27944653
94	Melanoma_Homo sapiens_hsa05218	0.24946514
95	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.24798931
96	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.24471720
97	mTOR signaling pathway_Homo sapiens_hsa04150	0.24301888
98	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.23577865
99	ErbB signaling pathway_Homo sapiens_hsa04012	0.23108603
100	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.22695473

IFIT6P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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