IFITM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)9.75329057
2viral transcription (GO:0019083)7.48485298
3translational termination (GO:0006415)7.14611854
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.64879315
5platelet dense granule organization (GO:0060155)6.34045215
6ribosomal small subunit biogenesis (GO:0042274)6.22460359
7translational elongation (GO:0006414)6.15013467
8DNA deamination (GO:0045006)6.09262346
9SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.07124097
10definitive hemopoiesis (GO:0060216)5.94041340
11cotranslational protein targeting to membrane (GO:0006613)5.93921410
12protein targeting to ER (GO:0045047)5.91244607
13maturation of SSU-rRNA (GO:0030490)5.71825820
14protein localization to endoplasmic reticulum (GO:0070972)5.67348499
15establishment of protein localization to endoplasmic reticulum (GO:0072599)5.63261480
16viral life cycle (GO:0019058)5.55322718
17nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.50395180
18antigen processing and presentation via MHC class Ib (GO:0002475)5.30561979
19cellular protein complex disassembly (GO:0043624)5.29721801
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.23272166
21negative regulation of cell killing (GO:0031342)5.23272166
22negative regulation of erythrocyte differentiation (GO:0045647)5.15047267
23translational initiation (GO:0006413)4.95532700
24mature B cell differentiation involved in immune response (GO:0002313)4.82683043
25* response to interferon-beta (GO:0035456)4.74159579
26protein complex disassembly (GO:0043241)4.73465551
27positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.64013977
28megakaryocyte development (GO:0035855)4.47131791
29macromolecular complex disassembly (GO:0032984)4.40028925
30regulation of B cell receptor signaling pathway (GO:0050855)4.38272977
31cellular response to interleukin-15 (GO:0071350)4.21311118
32endosome to melanosome transport (GO:0035646)4.20741346
33endosome to pigment granule transport (GO:0043485)4.20741346
34nuclear-transcribed mRNA catabolic process (GO:0000956)4.09242410
35response to interleukin-15 (GO:0070672)4.03459217
36negative T cell selection (GO:0043383)4.02157107
37cytidine catabolic process (GO:0006216)4.00669904
38cytidine deamination (GO:0009972)4.00669904
39cytidine metabolic process (GO:0046087)4.00669904
40secretory granule organization (GO:0033363)3.97040776
41antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.95618588
42mRNA catabolic process (GO:0006402)3.95164673
43protein targeting to membrane (GO:0006612)3.88082280
44* response to interferon-alpha (GO:0035455)3.85731790
45antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.84856958
46negative thymic T cell selection (GO:0045060)3.83142181
47leukocyte aggregation (GO:0070486)3.75288627
48defense response to protozoan (GO:0042832)3.69257226
49RNA catabolic process (GO:0006401)3.67040711
50regulation of T cell mediated cytotoxicity (GO:0001914)3.66844908
51response to protozoan (GO:0001562)3.65520921
52lymph node development (GO:0048535)3.60667698
53mature B cell differentiation (GO:0002335)3.60063632
54antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.59802486
55antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.59802486
56positive regulation of gamma-delta T cell activation (GO:0046645)3.59733818
57cellular response to interferon-beta (GO:0035458)3.58928883
58positive regulation of B cell differentiation (GO:0045579)3.57703911
59ribosomal large subunit biogenesis (GO:0042273)3.57158680
60pyrimidine ribonucleoside catabolic process (GO:0046133)3.47536491
61proteasome assembly (GO:0043248)3.46370285
62T cell migration (GO:0072678)3.45376216
63detection of bacterium (GO:0016045)3.44386431
64* regulation of viral genome replication (GO:0045069)3.43326016
65lymphoid progenitor cell differentiation (GO:0002320)3.42794083
66positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.41499283
67ribonucleoprotein complex biogenesis (GO:0022613)3.41181471
68negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.40248781
69interferon-gamma-mediated signaling pathway (GO:0060333)3.39273279
70positive thymic T cell selection (GO:0045059)3.35592137
71daunorubicin metabolic process (GO:0044597)3.34708560
72polyketide metabolic process (GO:0030638)3.34708560
73doxorubicin metabolic process (GO:0044598)3.34708560
74translation (GO:0006412)3.32829232
75mucosal-associated lymphoid tissue development (GO:0048537)3.32632346
76Peyers patch development (GO:0048541)3.32632346
77regulation of alpha-beta T cell proliferation (GO:0046640)3.30335610
78purine-containing compound salvage (GO:0043101)3.28666068
79detection of other organism (GO:0098543)3.27872993
80DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.26663690
81positive regulation of respiratory burst (GO:0060267)3.23715587
82positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.23354825
83regulation of T cell tolerance induction (GO:0002664)3.23322364
84negative regulation of lymphocyte mediated immunity (GO:0002707)3.18767089
85regulation of leukocyte mediated cytotoxicity (GO:0001910)3.17817409
86signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.16719807
87intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.16719807
88regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.15538576
89regulation of natural killer cell mediated immunity (GO:0002715)3.15538576
90signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.15158993
91signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.15158993
92signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.15158993
93regulation of cellular amino acid metabolic process (GO:0006521)3.11499046
94antigen processing and presentation of endogenous antigen (GO:0019883)3.10304978
95regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.10273808
96antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.08387417
97negative regulation of phagocytosis (GO:0050765)3.06725493
98negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.04592610
99negative regulation of ligase activity (GO:0051352)3.04592610
100positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.03648370
101thymic T cell selection (GO:0045061)3.02169342
102pseudouridine synthesis (GO:0001522)3.01318144
103interferon-gamma production (GO:0032609)3.01111228
104negative regulation of leukocyte mediated immunity (GO:0002704)3.01102477
105* defense response to virus (GO:0051607)2.99752508
106positive T cell selection (GO:0043368)2.99110940
107regulation of B cell differentiation (GO:0045577)2.98708700
108signal transduction involved in DNA integrity checkpoint (GO:0072401)2.98474789
109signal transduction involved in DNA damage checkpoint (GO:0072422)2.98474789
110positive regulation of alpha-beta T cell proliferation (GO:0046641)2.97970119
111regulation of respiratory burst (GO:0060263)2.97885208
112regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.97481875
113regulation of erythrocyte differentiation (GO:0045646)2.96650519
114positive regulation of interferon-alpha production (GO:0032727)2.96551525
115respiratory chain complex IV assembly (GO:0008535)2.93599593
116positive regulation by symbiont of host defense response (GO:0052509)2.92751884
117modulation by symbiont of host defense response (GO:0052031)2.92751884
118modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.92751884
119modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.92751884
120positive regulation by organism of defense response of other organism involved in symbiotic interact2.92751884
121modulation by symbiont of host immune response (GO:0052553)2.92751884
122positive regulation of T cell mediated immunity (GO:0002711)2.92573099
123negative regulation of T cell mediated immunity (GO:0002710)2.91565332
124* negative regulation of viral process (GO:0048525)2.91506474
125regulation of regulatory T cell differentiation (GO:0045589)2.91353660
126cellular response to interferon-alpha (GO:0035457)2.91151094
127negative regulation of bone mineralization (GO:0030502)2.90722689
128negative regulation of innate immune response (GO:0045824)2.90162059
129signal transduction involved in cell cycle checkpoint (GO:0072395)2.90036132
130regulation of natural killer cell differentiation (GO:0032823)2.89157554
131regulation of gamma-delta T cell differentiation (GO:0045586)2.89046225
132positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.86940960
133myeloid dendritic cell activation (GO:0001773)2.86875031
134respiratory burst (GO:0045730)2.85906163
135positive regulation of cell killing (GO:0031343)2.85518946
136regulation of cell killing (GO:0031341)2.84449959
137fucose catabolic process (GO:0019317)2.83992503
138L-fucose metabolic process (GO:0042354)2.83992503
139L-fucose catabolic process (GO:0042355)2.83992503
140T cell selection (GO:0045058)2.83735492
141T cell homeostasis (GO:0043029)2.83490031
142* response to type I interferon (GO:0034340)2.82624585
143* cellular response to type I interferon (GO:0071357)2.81358754
144* type I interferon signaling pathway (GO:0060337)2.81358754
145CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.81310617
146exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.80813070
147neutrophil activation involved in immune response (GO:0002283)2.80710919
148heparin biosynthetic process (GO:0030210)2.79323494
149heparin metabolic process (GO:0030202)2.79323494
150regulation of interferon-alpha production (GO:0032647)2.79057774
151positive regulation of defense response to virus by host (GO:0002230)2.78511150
152regulation of T cell mediated immunity (GO:0002709)2.77997567
153telomere maintenance via semi-conservative replication (GO:0032201)2.77526729
154positive regulation of T cell mediated cytotoxicity (GO:0001916)2.77285234
155formation of translation preinitiation complex (GO:0001731)2.76439157
156regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.75546539
157* negative regulation of viral genome replication (GO:0045071)2.74856096
158tRNA methylation (GO:0030488)2.70068629
159B cell mediated immunity (GO:0019724)2.69521268
160positive regulation of granulocyte differentiation (GO:0030854)2.68382825
161myeloid dendritic cell differentiation (GO:0043011)2.67988847
162* negative regulation of viral entry into host cell (GO:0046597)2.67600142
163granulocyte differentiation (GO:0030851)2.67084659
164rRNA processing (GO:0006364)2.66333179
165cellular component biogenesis (GO:0044085)2.65618955
166immunoglobulin mediated immune response (GO:0016064)2.65249971
167IMP metabolic process (GO:0046040)2.62216420
168thrombin receptor signaling pathway (GO:0070493)2.61913020
169regulation of gamma-delta T cell activation (GO:0046643)2.61392325
170nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.61210417
171deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.60174377
172embryonic hemopoiesis (GO:0035162)2.59672995
173T-helper 1 type immune response (GO:0042088)2.59086614
174phospholipid scrambling (GO:0017121)2.58941142
175mast cell activation (GO:0045576)2.57829755
176B cell activation involved in immune response (GO:0002312)2.57818644
177rRNA metabolic process (GO:0016072)2.56536561
178establishment of protein localization to membrane (GO:0090150)2.55160955

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SCL_19346495_ChIP-Seq_HPC-7_Human4.58550276
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.00290469
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.58637147
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.39926615
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.38944725
6RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.24895888
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.21387491
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.99363543
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.98567593
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.94244447
11TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.93573088
12SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.93251031
13FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.73652389
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.73478104
15E2F7_22180533_ChIP-Seq_HELA_Human2.66082568
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.57321703
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.50882220
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.50125816
19NOTCH1_21737748_ChIP-Seq_TLL_Human2.40813108
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.30097524
21LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.25620389
22MYC_18358816_ChIP-ChIP_MESCs_Mouse2.23420635
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.22814178
24MYC_19079543_ChIP-ChIP_MESCs_Mouse2.18452623
25EST1_17652178_ChIP-ChIP_JURKAT_Human2.15785453
26VDR_21846776_ChIP-Seq_THP-1_Human2.13470324
27* SPI1_23547873_ChIP-Seq_NB4_Human2.12978276
28ERG_20887958_ChIP-Seq_HPC-7_Mouse2.11240666
29MYB_21317192_ChIP-Seq_ERMYB_Mouse2.07816349
30MYC_22102868_ChIP-Seq_BL_Human2.05422891
31GABP_17652178_ChIP-ChIP_JURKAT_Human2.02015427
32HOXB4_20404135_ChIP-ChIP_EML_Mouse1.99676646
33LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.99058700
34SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.97289837
35MYC_19030024_ChIP-ChIP_MESCs_Mouse1.90787865
36IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.87675497
37STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.85899466
38ETS1_20019798_ChIP-Seq_JURKAT_Human1.84883311
39MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.84366601
40XRN2_22483619_ChIP-Seq_HELA_Human1.81469794
41JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.80380671
42VDR_23849224_ChIP-Seq_CD4+_Human1.76122560
43STAT4_19710469_ChIP-ChIP_TH1__Mouse1.74362724
44RUNX1_22412390_ChIP-Seq_EML_Mouse1.73531534
45GATA3_27048872_Chip-Seq_THYMUS_Human1.69431582
46GATA3_26560356_Chip-Seq_TH2_Human1.67608158
47GATA1_22383799_ChIP-Seq_G1ME_Mouse1.66556244
48ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.66532549
49SRF_21415370_ChIP-Seq_HL-1_Mouse1.64446605
50FOXP3_21729870_ChIP-Seq_TREG_Human1.62802783
51VDR_24763502_ChIP-Seq_THP-1_Human1.61894799
52GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.57877077
53GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.54037531
54* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.52354462
55CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.50255844
56TCF7_22412390_ChIP-Seq_EML_Mouse1.48710528
57GATA2_22383799_ChIP-Seq_G1ME_Mouse1.48200352
58STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.47732660
59KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.46802258
60KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.46802258
61KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.46802258
62HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.46072718
63* MAF_26560356_Chip-Seq_TH1_Human1.44067674
64CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.43737614
65CIITA_25753668_ChIP-Seq_RAJI_Human1.43713592
66IRF8_21731497_ChIP-ChIP_J774_Mouse1.40272219
67MYB_26560356_Chip-Seq_TH2_Human1.39432309
68NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.38390431
69FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.37627424
70CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.36359672
71EGR1_19374776_ChIP-ChIP_THP-1_Human1.34777161
72CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.31934994
73TTF2_22483619_ChIP-Seq_HELA_Human1.31515973
74UTX_26944678_Chip-Seq_JUKART_Human1.28744780
75* MYB_26560356_Chip-Seq_TH1_Human1.27875577
76STAT3_1855785_ChIP-Seq_MESCs_Mouse1.27584125
77CREB1_15753290_ChIP-ChIP_HEK293T_Human1.26206829
78NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.26032491
79ZFX_18555785_ChIP-Seq_MESCs_Mouse1.25039861
80NELFA_20434984_ChIP-Seq_ESCs_Mouse1.24492602
81ELK1_19687146_ChIP-ChIP_HELA_Human1.24437304
82GABP_19822575_ChIP-Seq_HepG2_Human1.23532882
83RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.23492162
84THAP11_20581084_ChIP-Seq_MESCs_Mouse1.23401883
85EGR1_23403033_ChIP-Seq_LIVER_Mouse1.20043209
86SPI1_23127762_ChIP-Seq_K562_Human1.19933683
87SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.19602149
88TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19213521
89DCP1A_22483619_ChIP-Seq_HELA_Human1.18127320
90* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.16367593
91TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16323840
92PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.15541299
93GATA1_19941827_ChIP-Seq_MEL_Mouse1.14055475
94KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.13569790
95SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12915642
96GATA1_22025678_ChIP-Seq_K562_Human1.07824925
97E2F4_17652178_ChIP-ChIP_JURKAT_Human1.07367146
98CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07334728
99POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.06360823
100* MAF_26560356_Chip-Seq_TH2_Human1.05185049
101RBPJ_22232070_ChIP-Seq_NCS_Mouse1.05072522
102BRD4_27068464_Chip-Seq_AML-cells_Mouse1.04863508
103FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.04342875
104CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00256264
105CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00087714
106ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.00029430
107IRF8_27001747_Chip-Seq_BMDM_Mouse0.99974481
108E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.99743823
109FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.99106176
110STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.98344419
111CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.98162952
112ETS1_22383799_ChIP-Seq_G1ME_Mouse0.96107717
113PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95820661
114RUNX_20019798_ChIP-Seq_JUKART_Human0.94537363
115PU.1_20513432_ChIP-Seq_Bcells_Mouse0.93332107
116CTCF_18555785_ChIP-Seq_MESCs_Mouse0.93022583
117ELK3_25401928_ChIP-Seq_HUVEC_Human0.91814875
118EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.91768858
119RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.91720436
120FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90302331
121RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.88427488
122* BCOR_27268052_Chip-Seq_Bcells_Human0.88159527
123* BCL6_27268052_Chip-Seq_Bcells_Human0.87325527
124NANOG_18555785_ChIP-Seq_MESCs_Mouse0.86666805
125YY1_21170310_ChIP-Seq_MESCs_Mouse0.86438091
126CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85231098
127CTCF_26484167_Chip-Seq_Bcells_Mouse0.84674652

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.39749580
2MP0002396_abnormal_hematopoietic_system3.38034043
3MP0005174_abnormal_tail_pigmentation3.31519145
4MP0004808_abnormal_hematopoietic_stem3.29558569
5MP0001545_abnormal_hematopoietic_system3.26312570
6MP0005397_hematopoietic_system_phenotyp3.26312570
7MP0001835_abnormal_antigen_presentation3.25502024
8MP0000685_abnormal_immune_system3.18066227
9MP0009785_altered_susceptibility_to3.00794448
10MP0005671_abnormal_response_to2.71543932
11MP0005464_abnormal_platelet_physiology2.59811013
12MP0005075_abnormal_melanosome_morpholog2.58655728
13MP0000465_gastrointestinal_hemorrhage2.52011198
14MP0002254_reproductive_system_inflammat2.46630076
15MP0002877_abnormal_melanocyte_morpholog2.46403945
16MP0009278_abnormal_bone_marrow2.33185391
17MP0005025_abnormal_response_to2.29274994
18MP0000490_abnormal_crypts_of2.28766355
19MP0003866_abnormal_defecation2.19442788
20MP0002095_abnormal_skin_pigmentation2.16842902
21MP0003724_increased_susceptibility_to2.13797701
22MP0002148_abnormal_hypersensitivity_rea2.10512992
23MP0002398_abnormal_bone_marrow2.08873151
24MP0003806_abnormal_nucleotide_metabolis2.00489789
25MP0003436_decreased_susceptibility_to2.00007210
26MP0001800_abnormal_humoral_immune1.99838376
27MP0010155_abnormal_intestine_physiology1.99335563
28MP0000689_abnormal_spleen_morphology1.91865913
29MP0002277_abnormal_respiratory_mucosa1.90721238
30MP0001853_heart_inflammation1.90534086
31MP0002452_abnormal_antigen_presenting1.89950458
32MP0002420_abnormal_adaptive_immunity1.89002810
33MP0002723_abnormal_immune_serum1.87675286
34MP0003763_abnormal_thymus_physiology1.87009540
35MP0001819_abnormal_immune_cell1.85949497
36MP0002722_abnormal_immune_system1.84643849
37MP0000716_abnormal_immune_system1.75268954
38MP0002138_abnormal_hepatobiliary_system1.74510408
39MP0001873_stomach_inflammation1.73961229
40MP0005000_abnormal_immune_tolerance1.67223912
41MP0001986_abnormal_taste_sensitivity1.66067236
42MP0002429_abnormal_blood_cell1.65670403
43MP0004147_increased_porphyrin_level1.60699595
44MP0002419_abnormal_innate_immunity1.59914041
45MP0009333_abnormal_splenocyte_physiolog1.50636670
46MP0003693_abnormal_embryo_hatching1.50515695
47MP0005387_immune_system_phenotype1.47661520
48MP0001790_abnormal_immune_system1.47661520
49MP0006292_abnormal_olfactory_placode1.45560907
50MP0010368_abnormal_lymphatic_system1.42974438
51MP0000015_abnormal_ear_pigmentation1.40306573
52MP0002166_altered_tumor_susceptibility1.37785369
53MP0008058_abnormal_DNA_repair1.35404499
54MP0000858_altered_metastatic_potential1.34514289
55MP0002933_joint_inflammation1.29840756
56MP0003943_abnormal_hepatobiliary_system1.29195685
57MP0000703_abnormal_thymus_morphology1.24547053
58MP0008007_abnormal_cellular_replicative1.23939342
59MP0001845_abnormal_inflammatory_respons1.23082838
60MP0000372_irregular_coat_pigmentation1.21729142
61MP0002405_respiratory_system_inflammati1.20823350
62MP0002234_abnormal_pharynx_morphology1.18588794
63MP0003303_peritoneal_inflammation1.18362771
64MP0003136_yellow_coat_color1.15859920
65MP0008057_abnormal_DNA_replication1.15150576
66MP0008469_abnormal_protein_level1.13633520
67MP0005409_darkened_coat_color1.11054227
68MP0003011_delayed_dark_adaptation1.10561598
69MP0004957_abnormal_blastocyst_morpholog1.10369210
70MP0004381_abnormal_hair_follicle1.09639282
71MP0002132_abnormal_respiratory_system1.07320558
72MP0003448_altered_tumor_morphology1.04840715
73MP0002006_tumorigenesis1.03095578
74MP0002019_abnormal_tumor_incidence1.02959179
75MP0003868_abnormal_feces_composition1.02402687
76MP0002163_abnormal_gland_morphology1.01954117
77MP0003077_abnormal_cell_cycle1.00565108
78MP0003828_pulmonary_edema1.00450015
79MP0010094_abnormal_chromosome_stability0.98404545
80MP0003186_abnormal_redox_activity0.97859885
81MP0008004_abnormal_stomach_pH0.97817722
82MP0000313_abnormal_cell_death0.96437689
83MP0006082_CNS_inflammation0.94703893
84MP0008995_early_reproductive_senescence0.92103592
85MP0006054_spinal_hemorrhage0.92093069
86MP0005390_skeleton_phenotype0.91902968
87MP0005310_abnormal_salivary_gland0.91190968
88MP0000681_abnormal_thyroid_gland0.91058888
89MP0001879_abnormal_lymphatic_vessel0.90714246
90MP0006036_abnormal_mitochondrial_physio0.89821394
91MP0003656_abnormal_erythrocyte_physiolo0.87772751
92MP0008872_abnormal_physiological_respon0.87751125
93MP0000477_abnormal_intestine_morphology0.86557959
94MP0003567_abnormal_fetal_cardiomyocyte0.83140533
95MP0001663_abnormal_digestive_system0.81597067
96MP0003195_calcinosis0.81106061
97MP0003191_abnormal_cellular_cholesterol0.80669535
98MP0001348_abnormal_lacrimal_gland0.79805625
99MP0005503_abnormal_tendon_morphology0.78919644
100MP0005166_decreased_susceptibility_to0.76514255
101MP0002075_abnormal_coat/hair_pigmentati0.74912510
102MP0004510_myositis0.74861462
103MP0000343_altered_response_to0.74760701
104MP0009765_abnormal_xenobiotic_induced0.74744366
105MP0004947_skin_inflammation0.73842331
106MP0009764_decreased_sensitivity_to0.71457435
107MP0001851_eye_inflammation0.70701075
108MP0001533_abnormal_skeleton_physiology0.69947725
109MP0001542_abnormal_bone_strength0.69691369
110MP0002089_abnormal_postnatal_growth/wei0.67836882
111MP0002998_abnormal_bone_remodeling0.67772282
112MP0003786_premature_aging0.66844607
113MP0003300_gastrointestinal_ulcer0.66371626
114MP0000371_diluted_coat_color0.65654633
115MP0008260_abnormal_autophagy0.65114226
116MP0003638_abnormal_response/metabolism_0.64947959
117MP0003890_abnormal_embryonic-extraembry0.64157401
118MP0002938_white_spotting0.63594508
119MP0009763_increased_sensitivity_to0.63586431
120MP0002177_abnormal_outer_ear0.62136543
121MP0003795_abnormal_bone_structure0.61924034
122MP0000678_abnormal_parathyroid_gland0.61887464
123MP0005670_abnormal_white_adipose0.61763708
124MP0001188_hyperpigmentation0.61676221
125MP0000598_abnormal_liver_morphology0.61540608
126MP0004883_abnormal_blood_vessel0.59871657
127MP0000613_abnormal_salivary_gland0.59719673
128MP0008873_increased_physiological_sensi0.58628766
129MP0006035_abnormal_mitochondrial_morpho0.57547462
130MP0001881_abnormal_mammary_gland0.57193830
131MP0005319_abnormal_enzyme/_coenzyme0.53271287
132MP0001919_abnormal_reproductive_system0.52036272
133MP0001764_abnormal_homeostasis0.50503219
134MP0005584_abnormal_enzyme/coenzyme_acti0.50093105
135MP0005083_abnormal_biliary_tract0.47286112
136MP0005084_abnormal_gallbladder_morpholo0.44022436

Predicted human phenotypes

RankGene SetZ-score
1Thrombocytosis (HP:0001894)6.34693863
2Abnormality of cells of the erythroid lineage (HP:0012130)6.16557747
3Abnormal number of erythroid precursors (HP:0012131)5.83781444
4Aplastic anemia (HP:0001915)5.28310827
5Reticulocytopenia (HP:0001896)5.10223142
6Prolonged bleeding time (HP:0003010)4.84246422
7Eczematoid dermatitis (HP:0000976)4.52657379
8Stomatitis (HP:0010280)4.34881052
9IgM deficiency (HP:0002850)4.13184510
10Petechiae (HP:0000967)4.11188064
11Increased IgM level (HP:0003496)4.03918384
12Myositis (HP:0100614)3.99044000
13Elevated erythrocyte sedimentation rate (HP:0003565)3.95082673
14Type 2 muscle fiber atrophy (HP:0003554)3.84347742
15Abnormality of T cell number (HP:0011839)3.84301263
16Pallor (HP:0000980)3.76979999
17Muscle fiber atrophy (HP:0100295)3.75655031
18Nonprogressive disorder (HP:0003680)3.68259336
19T lymphocytopenia (HP:0005403)3.67156206
20Encephalitis (HP:0002383)3.59931323
21Epistaxis (HP:0000421)3.48364362
22Macrocytic anemia (HP:0001972)3.43320654
23Autoimmune hemolytic anemia (HP:0001890)3.37154677
24Type I transferrin isoform profile (HP:0003642)3.36772409
25Pustule (HP:0200039)3.33584006
26Amaurosis fugax (HP:0100576)3.33001006
27Recurrent cutaneous fungal infections (HP:0011370)3.22935323
28Chronic mucocutaneous candidiasis (HP:0002728)3.22935323
29Abnormal delayed hypersensitivity skin test (HP:0002963)3.18987874
30Keratoconjunctivitis sicca (HP:0001097)3.16479109
31Abnormal platelet function (HP:0011869)3.15163965
32Impaired platelet aggregation (HP:0003540)3.15163965
33Gastrointestinal infarctions (HP:0005244)3.14050375
34Keratoconjunctivitis (HP:0001096)3.12029557
35Abnormality of the heme biosynthetic pathway (HP:0010472)3.09630265
36Abnormality of T cell physiology (HP:0011840)3.09246850
37Eosinophilia (HP:0001880)3.07564828
38Granulocytopenia (HP:0001913)3.06229681
39Mediastinal lymphadenopathy (HP:0100721)2.99073068
40Reduced antithrombin III activity (HP:0001976)2.97531098
41Anorexia (HP:0002039)2.94945734
42Myelodysplasia (HP:0002863)2.93415218
43Lymphopenia (HP:0001888)2.90020275
44Recurrent skin infections (HP:0001581)2.86639281
45Abnormality of cells of the lymphoid lineage (HP:0012140)2.84131619
46Leukocytosis (HP:0001974)2.82131604
47Radial bowing (HP:0002986)2.80677679
48Chronic otitis media (HP:0000389)2.79117486
49Obstructive lung disease (HP:0006536)2.78533761
50Chronic obstructive pulmonary disease (HP:0006510)2.78533761
51Severe combined immunodeficiency (HP:0004430)2.77265710
52Abnormality of the nasal mucosa (HP:0000433)2.75327294
53Colon cancer (HP:0003003)2.74718001
54Abnormality of eosinophils (HP:0001879)2.70127384
55Purpura (HP:0000979)2.69974485
56Hypochromic microcytic anemia (HP:0004840)2.66813269
57Respiratory difficulties (HP:0002880)2.64106133
58Hypochromic anemia (HP:0001931)2.63340744
59Abnormality of B cell number (HP:0010975)2.59113444
60Mitochondrial inheritance (HP:0001427)2.58158114
61Hypergammaglobulinemia (HP:0010702)2.57793359
62Beaking of vertebral bodies (HP:0004568)2.57524745
63Gingival bleeding (HP:0000225)2.57325949
64Pulmonary infiltrates (HP:0002113)2.55461769
65Stomach cancer (HP:0012126)2.54395945
66Recurrent gram-negative bacterial infections (HP:0005420)2.53095148
67Acute necrotizing encephalopathy (HP:0006965)2.52147695
68Urticaria (HP:0001025)2.52026436
69Asplenia (HP:0001746)2.51566209
70Albinism (HP:0001022)2.50482583
71Weak cry (HP:0001612)2.47961682
72Panhypogammaglobulinemia (HP:0003139)2.47943764
7311 pairs of ribs (HP:0000878)2.47675682
74Aplasia/Hypoplasia of the sacrum (HP:0008517)2.47540603
75Cellulitis (HP:0100658)2.46872833
76Hemoptysis (HP:0002105)2.46240805
77Recurrent abscess formation (HP:0002722)2.44619031
78Orchitis (HP:0100796)2.44178047
79Increased IgE level (HP:0003212)2.43464075
80Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.43222732
81Abnormal protein N-linked glycosylation (HP:0012347)2.43222732
82Abnormal protein glycosylation (HP:0012346)2.43222732
83Abnormal glycosylation (HP:0012345)2.43222732
84Poikiloderma (HP:0001029)2.38994889
85Abnormal mitochondria in muscle tissue (HP:0008316)2.38979058
86Increased CSF lactate (HP:0002490)2.37873892
87Spontaneous hematomas (HP:0007420)2.35220963
88Exertional dyspnea (HP:0002875)2.34785038
89Oral leukoplakia (HP:0002745)2.34597100
90Gastrointestinal inflammation (HP:0004386)2.31925461
91Absent rod-and cone-mediated responses on ERG (HP:0007688)2.31471976
92Recurrent bronchitis (HP:0002837)2.30259199
93Hepatocellular necrosis (HP:0001404)2.27352683
94Fatigue (HP:0012378)2.26790478
95Aplasia/Hypoplasia of the spleen (HP:0010451)2.25815821
96Recurrent bacterial skin infections (HP:0005406)2.25718692
97Combined immunodeficiency (HP:0005387)2.25111499
98Acute myeloid leukemia (HP:0004808)2.25087098
99Pancytopenia (HP:0001876)2.21668798
100Migraine (HP:0002076)2.19559179
101Annular pancreas (HP:0001734)2.19455270
102Microcytic anemia (HP:0001935)2.19108784
103Menorrhagia (HP:0000132)2.19068386
104Chest pain (HP:0100749)2.18163111
105Interstitial pulmonary disease (HP:0006530)2.18113850
106Increased hepatocellular lipid droplets (HP:0006565)2.17403961
107Acute encephalopathy (HP:0006846)2.15654622
108Recurrent viral infections (HP:0004429)2.15092334
109Supernumerary spleens (HP:0009799)2.13785075
110Acute hepatic failure (HP:0006554)2.13376948
111Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.12415640
112Hypoproteinemia (HP:0003075)2.11763149
113Meningitis (HP:0001287)2.08385323
114Decreased activity of mitochondrial respiratory chain (HP:0008972)2.07116730
115Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.07116730
116Abnormality of T cells (HP:0002843)2.06985485
117Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.05247251
118Gonadotropin excess (HP:0000837)2.05074200
119Progressive macrocephaly (HP:0004481)2.04936675
120Gastrointestinal stroma tumor (HP:0100723)2.04569190
121Inflammation of the large intestine (HP:0002037)2.04406396
122Lymphoma (HP:0002665)2.04179645
123Arterial thrombosis (HP:0004420)2.03952124
124Skin rash (HP:0000988)2.02663910
125Increased intramyocellular lipid droplets (HP:0012240)2.02343294
126Premature loss of primary teeth (HP:0006323)2.01053976
127Nasal polyposis (HP:0100582)1.99818580
128Thoracic kyphosis (HP:0002942)1.99467421
129Agammaglobulinemia (HP:0004432)1.98590210
130Broad face (HP:0000283)1.97941293
131IgG deficiency (HP:0004315)1.97073865
132Increased muscle lipid content (HP:0009058)1.96997809
133Lipid accumulation in hepatocytes (HP:0006561)1.95539775
134Gangrene (HP:0100758)1.94771564
135Bowed forearm bones (HP:0003956)1.94718815
136Bowing of the arm (HP:0006488)1.94718815
137Erythema (HP:0010783)1.92628596
138Bronchitis (HP:0012387)1.92568094
139Autoimmune thrombocytopenia (HP:0001973)1.92276544
140Depressed nasal tip (HP:0000437)1.91558413
141Recurrent fungal infections (HP:0002841)1.90558043
142B lymphocytopenia (HP:0010976)1.90513097
143Keratitis (HP:0000491)1.90196267
144Increased neuronal autofluorescent lipopigment (HP:0002074)1.88224267
145Chronic sinusitis (HP:0011109)1.87939950
146Abnormality of macrophages (HP:0004311)1.87723076
147Severe visual impairment (HP:0001141)1.87205339
148Abnormality of the prostate (HP:0008775)1.87158189
149Abnormality of the pleura (HP:0002103)1.85960074
150Acute lymphatic leukemia (HP:0006721)1.85219708
151Vasculitis (HP:0002633)1.85194439
152Prostate neoplasm (HP:0100787)1.85030749
153Neutropenia (HP:0001875)1.84567716
154Easy fatigability (HP:0003388)1.83640435
155Chronic diarrhea (HP:0002028)1.83245099
156Abnormal platelet volume (HP:0011876)1.82848719
157Retrobulbar optic neuritis (HP:0100654)1.81905875
158Optic neuritis (HP:0100653)1.81905875
159Bruising susceptibility (HP:0000978)1.81367805

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MUSK3.98906436
2TGFBR13.37304222
3NME23.28547811
4TESK23.19852313
5STK163.07153111
6MST42.97983106
7MAP4K12.95402854
8EEF2K2.82014315
9KIT2.67736905
10CDK192.66379062
11TNIK2.64929618
12VRK22.61920807
13GRK62.35007591
14FLT32.34417630
15RPS6KB22.33465863
16TGFBR22.30297704
17TIE12.28147761
18BTK2.19057842
19JAK12.05496424
20ACVR1B2.03177098
21TEC1.97133117
22MAP3K121.92780490
23CSK1.83450070
24MATK1.83249279
25JAK31.76986492
26WEE11.73961413
27STK101.73714485
28ITK1.66701539
29MAP2K31.61997007
30PIM21.54665297
31TBK11.51801685
32SIK31.43137737
33ZAP701.40083750
34CSF1R1.39893208
35FGFR41.37780640
36MAP3K111.32482999
37DYRK31.31783799
38ERN11.29642793
39PBK1.28062178
40PRKG21.25646598
41BCKDK1.25391783
42MAPKAPK51.24908486
43KDR1.23795501
44IKBKB1.23472482
45CDK81.23382085
46MKNK11.21596234
47LRRK21.21566376
48MAP3K141.21061780
49NME11.20742607
50TXK1.20203848
51SYK1.19400233
52CAMKK21.17806116
53NUAK11.16449127
54IRAK41.15776895
55IKBKE1.13546338
56MAP2K61.12752353
57PASK1.09666431
58ADRBK21.09634365
59EPHB11.09548691
60MARK31.08942541
61CAMK11.05741566
62PKN21.04406455
63MAPKAPK31.01351656
64FES1.01100742
65MYLK0.99578525
66VRK10.99293551
67ZAK0.97646801
68NLK0.97185765
69PIM10.94793433
70TLK10.93639397
71RPS6KA40.93624437
72PRKCQ0.91391973
73EIF2AK30.87786297
74SRPK10.87238461
75SCYL20.87073924
76BLK0.82198420
77LYN0.82087427
78CDK70.81047548
79TYK20.80310266
80TAOK30.78977204
81CLK10.76886373
82TNK20.76336222
83HIPK20.75335922
84MKNK20.74543082
85IRAK30.73622779
86LCK0.71402906
87BRSK20.71235415
88PAK40.70873208
89MAP3K30.70439975
90RIPK40.69014053
91EIF2AK20.65518853
92BMPR20.65498101
93MAP3K80.64386108
94IRAK10.58049840
95GRK10.57313810
96MAP3K130.57109466
97BMPR1B0.56054086
98MAP3K70.54499675
99HCK0.49906316
100GRK70.49611770
101ILK0.49468755
102RAF10.49407814
103FGR0.48637482
104EIF2AK10.48233467
105OXSR10.46301665
106PAK10.45374638
107MAPK40.43731765
108ATR0.43572200
109YES10.41673114
110RPS6KA50.40528897
111FYN0.38906991
112PTK60.38799088
113BMX0.38275063
114ALK0.37370973
115DAPK10.37334014
116EPHA30.37261921
117TESK10.36561291
118RPS6KA60.36319160
119CDK40.36105155
120FGFR30.35607137
121FER0.35446820
122MAP3K10.35261136
123ADRBK10.34831797
124PRKCD0.34314289
125CCNB10.33498961
126IGF1R0.33138864
127BUB10.32746809
128NEK20.32578634
129JAK20.32168507
130TRPM70.32062119
131PRKCH0.32043503
132PIK3CG0.31747419
133PINK10.31737311
134TAOK20.31103544
135ABL10.30815262
136CHUK0.30079016
137PLK40.29576027
138DYRK20.29469731
139STK40.29398450
140EGFR0.28564127
141ARAF0.28241713
142AURKB0.26953519
143CDK90.26826941
144RPS6KC10.26474527
145RPS6KL10.26474527
146TSSK60.25598535
147CSNK2A10.25423586
148CSNK2A20.24608794
149MAPKAPK20.24451751

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.78991930
2DNA replication_Homo sapiens_hsa030303.61469799
3Graft-versus-host disease_Homo sapiens_hsa053323.37584108
4Autoimmune thyroid disease_Homo sapiens_hsa053203.18073643
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.02129046
6Mismatch repair_Homo sapiens_hsa034302.88867277
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.49363921
8Base excision repair_Homo sapiens_hsa034102.43994359
9Type I diabetes mellitus_Homo sapiens_hsa049402.30797536
10Homologous recombination_Homo sapiens_hsa034402.21556167
11Staphylococcus aureus infection_Homo sapiens_hsa051502.19849805
12Oxidative phosphorylation_Homo sapiens_hsa001902.16251957
13RNA polymerase_Homo sapiens_hsa030202.11005413
14Pyrimidine metabolism_Homo sapiens_hsa002402.09568047
15Parkinsons disease_Homo sapiens_hsa050121.97819686
16Spliceosome_Homo sapiens_hsa030401.97721790
17Primary immunodeficiency_Homo sapiens_hsa053401.84358809
18Nucleotide excision repair_Homo sapiens_hsa034201.78387705
19Viral myocarditis_Homo sapiens_hsa054161.78010626
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.74491812
21RNA degradation_Homo sapiens_hsa030181.68633273
22Proteasome_Homo sapiens_hsa030501.64927947
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.64404426
24Transcriptional misregulation in cancer_Homo sapiens_hsa052021.56287747
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.56165929
26T cell receptor signaling pathway_Homo sapiens_hsa046601.50966718
27Jak-STAT signaling pathway_Homo sapiens_hsa046301.45330919
28Sulfur relay system_Homo sapiens_hsa041221.44482381
29Herpes simplex infection_Homo sapiens_hsa051681.44025257
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.40203778
31Folate biosynthesis_Homo sapiens_hsa007901.39538819
32N-Glycan biosynthesis_Homo sapiens_hsa005101.38090547
33Leishmaniasis_Homo sapiens_hsa051401.37269586
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.36167857
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.36126046
36Acute myeloid leukemia_Homo sapiens_hsa052211.34854659
37Platelet activation_Homo sapiens_hsa046111.31974287
38Measles_Homo sapiens_hsa051621.31729238
39NF-kappa B signaling pathway_Homo sapiens_hsa040641.28291395
40Antigen processing and presentation_Homo sapiens_hsa046121.27724841
41Hematopoietic cell lineage_Homo sapiens_hsa046401.21713033
42Purine metabolism_Homo sapiens_hsa002301.21249364
43Asthma_Homo sapiens_hsa053101.20274235
44Protein export_Homo sapiens_hsa030601.18220466
45* B cell receptor signaling pathway_Homo sapiens_hsa046621.14313549
46Huntingtons disease_Homo sapiens_hsa050161.12015968
47Rheumatoid arthritis_Homo sapiens_hsa053231.11953433
48Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.11181383
49Alzheimers disease_Homo sapiens_hsa050101.10985337
50Shigellosis_Homo sapiens_hsa051311.06048766
51RNA transport_Homo sapiens_hsa030131.03960331
52Tuberculosis_Homo sapiens_hsa051521.03001635
53Other glycan degradation_Homo sapiens_hsa005111.01388641
54Galactose metabolism_Homo sapiens_hsa000521.00635280
55NOD-like receptor signaling pathway_Homo sapiens_hsa046210.99105445
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.97464289
57Non-homologous end-joining_Homo sapiens_hsa034500.95564178
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.93395798
59Allograft rejection_Homo sapiens_hsa053300.92890940
60Toll-like receptor signaling pathway_Homo sapiens_hsa046200.91899627
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.91815994
62Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.91804312
63Drug metabolism - other enzymes_Homo sapiens_hsa009830.89722603
64Fanconi anemia pathway_Homo sapiens_hsa034600.88359141
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.86858642
66Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.86191725
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83903823
68p53 signaling pathway_Homo sapiens_hsa041150.81308990
69Basal transcription factors_Homo sapiens_hsa030220.79555406
70Influenza A_Homo sapiens_hsa051640.78568219
71Osteoclast differentiation_Homo sapiens_hsa043800.76565199
72Legionellosis_Homo sapiens_hsa051340.75553050
73Cell cycle_Homo sapiens_hsa041100.75521017
74Caffeine metabolism_Homo sapiens_hsa002320.75122388
75Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.74860929
76Pertussis_Homo sapiens_hsa051330.74198763
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.73623271
78Hepatitis B_Homo sapiens_hsa051610.72475528
79Thyroid cancer_Homo sapiens_hsa052160.72421189
80Malaria_Homo sapiens_hsa051440.70156259
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.68865601
82Pentose phosphate pathway_Homo sapiens_hsa000300.66928615
83Epstein-Barr virus infection_Homo sapiens_hsa051690.65023322
84Apoptosis_Homo sapiens_hsa042100.63066160
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55665831
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55353758
87Cysteine and methionine metabolism_Homo sapiens_hsa002700.55265182
88Toxoplasmosis_Homo sapiens_hsa051450.53299155
89Phagosome_Homo sapiens_hsa041450.53169911
90TNF signaling pathway_Homo sapiens_hsa046680.50200755
91Fructose and mannose metabolism_Homo sapiens_hsa000510.49982295
92Arachidonic acid metabolism_Homo sapiens_hsa005900.49740545
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49275208
94Leukocyte transendothelial migration_Homo sapiens_hsa046700.48627615
95Chronic myeloid leukemia_Homo sapiens_hsa052200.48463842
96Salmonella infection_Homo sapiens_hsa051320.48269957
97Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.47580703
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43062429
99Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.42873332
100Prolactin signaling pathway_Homo sapiens_hsa049170.41457988
101One carbon pool by folate_Homo sapiens_hsa006700.41445829
102African trypanosomiasis_Homo sapiens_hsa051430.40982397
103alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38144251
104HTLV-I infection_Homo sapiens_hsa051660.37770036
105Viral carcinogenesis_Homo sapiens_hsa052030.37329589
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36679578
107Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36341145
108Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36076041
109HIF-1 signaling pathway_Homo sapiens_hsa040660.35830295
110Notch signaling pathway_Homo sapiens_hsa043300.35571327
111AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.35496391
112Chemical carcinogenesis_Homo sapiens_hsa052040.33901406
113Nitrogen metabolism_Homo sapiens_hsa009100.30744746
114Glutathione metabolism_Homo sapiens_hsa004800.28763985
115Systemic lupus erythematosus_Homo sapiens_hsa053220.27874749
116Chemokine signaling pathway_Homo sapiens_hsa040620.27702887
117Hepatitis C_Homo sapiens_hsa051600.26793912
118Neurotrophin signaling pathway_Homo sapiens_hsa047220.26775422
119Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.23418558
120Regulation of autophagy_Homo sapiens_hsa041400.23057130
121Vitamin digestion and absorption_Homo sapiens_hsa049770.23008473
122Phototransduction_Homo sapiens_hsa047440.21897290
123Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.20880127
124Peroxisome_Homo sapiens_hsa041460.18499956
125Linoleic acid metabolism_Homo sapiens_hsa005910.15498172
126Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.13692200
127Olfactory transduction_Homo sapiens_hsa047400.12684798
128Metabolic pathways_Homo sapiens_hsa011000.11863591

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