IFITM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.69441149
2negative regulation of cell killing (GO:0031342)6.69441149
3ribosomal small subunit assembly (GO:0000028)6.35243247
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.69288305
5positive regulation by organism of defense response of other organism involved in symbiotic interact5.69288305
6modulation by symbiont of host immune response (GO:0052553)5.69288305
7positive regulation by symbiont of host defense response (GO:0052509)5.69288305
8modulation by symbiont of host defense response (GO:0052031)5.69288305
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.69288305
10neutrophil activation involved in immune response (GO:0002283)5.40911970
11positive regulation of gamma-delta T cell activation (GO:0046645)5.39451648
12detection of other organism (GO:0098543)5.25697372
13detection of bacterium (GO:0016045)5.19099093
14leukocyte aggregation (GO:0070486)5.03142768
15regulation of B cell receptor signaling pathway (GO:0050855)4.98526850
16DNA deamination (GO:0045006)4.76791631
17response to interleukin-15 (GO:0070672)4.75267586
18leukocyte migration involved in inflammatory response (GO:0002523)4.65938790
19viral transcription (GO:0019083)4.63876918
20macrophage activation involved in immune response (GO:0002281)4.62377188
21positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.60928995
22cellular response to interleukin-15 (GO:0071350)4.57405837
23translational termination (GO:0006415)4.47222225
24neutrophil activation (GO:0042119)4.44886452
25negative regulation of lymphocyte mediated immunity (GO:0002707)4.44075659
26detection of external biotic stimulus (GO:0098581)4.42675709
27respiratory burst (GO:0045730)4.32752853
28negative regulation of interleukin-12 production (GO:0032695)4.14392651
29* type I interferon signaling pathway (GO:0060337)4.10950349
30* cellular response to type I interferon (GO:0071357)4.10950349
31* response to type I interferon (GO:0034340)4.07349875
32cellular extravasation (GO:0045123)4.06365456
33negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.06042296
34SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.03486796
35ribosomal small subunit biogenesis (GO:0042274)4.03147244
36response to host immune response (GO:0052572)4.02479899
37response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.02479899
38detection of molecule of bacterial origin (GO:0032490)3.99854957
39translational elongation (GO:0006414)3.98035227
40negative regulation of leukocyte mediated immunity (GO:0002704)3.97528109
41regulation of interferon-beta biosynthetic process (GO:0045357)3.95560521
42granulocyte activation (GO:0036230)3.95329251
43protein targeting to ER (GO:0045047)3.89557277
44cotranslational protein targeting to membrane (GO:0006613)3.89096229
45regulation of gamma-delta T cell activation (GO:0046643)3.88127790
46detection of biotic stimulus (GO:0009595)3.85181945
47positive regulation of T cell mediated cytotoxicity (GO:0001916)3.81579507
48maturation of SSU-rRNA (GO:0030490)3.78083526
49microglial cell activation (GO:0001774)3.72066701
50positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.70095045
51myeloid cell activation involved in immune response (GO:0002275)3.69365428
52regulation of mast cell degranulation (GO:0043304)3.68776268
53protein localization to endoplasmic reticulum (GO:0070972)3.68553756
54response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.68371951
55response to host (GO:0075136)3.68371951
56response to host defenses (GO:0052200)3.68371951
57telomere maintenance via semi-conservative replication (GO:0032201)3.68124124
58establishment of protein localization to endoplasmic reticulum (GO:0072599)3.64941191
59regulation of T cell mediated cytotoxicity (GO:0001914)3.64395871
60DNA strand elongation involved in DNA replication (GO:0006271)3.54723825
61regulation of T cell tolerance induction (GO:0002664)3.54186365
62negative regulation of T cell mediated immunity (GO:0002710)3.50270777
63viral life cycle (GO:0019058)3.49269613
64nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.48551033
65neutrophil mediated immunity (GO:0002446)3.48264070
66regulation of gamma-delta T cell differentiation (GO:0045586)3.47264109
67leukocyte degranulation (GO:0043299)3.44256579
68DNA strand elongation (GO:0022616)3.41743655
69interferon-gamma-mediated signaling pathway (GO:0060333)3.39944167
70translational initiation (GO:0006413)3.39827596
71regulation of mast cell activation involved in immune response (GO:0033006)3.38925920
72regulation of B cell differentiation (GO:0045577)3.37487325
73regulation of tolerance induction (GO:0002643)3.34585391
74macrophage activation (GO:0042116)3.34025832
75regulation of myeloid leukocyte mediated immunity (GO:0002886)3.31896446
76regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.31577222
77regulation of natural killer cell mediated immunity (GO:0002715)3.31577222
78* response to interferon-beta (GO:0035456)3.30595045
79regulation of mast cell activation (GO:0033003)3.26665704
80formation of translation preinitiation complex (GO:0001731)3.26646434
81dendritic cell chemotaxis (GO:0002407)3.25872593
82defense response to protozoan (GO:0042832)3.24982750
83negative regulation of innate immune response (GO:0045824)3.24604603
84cellular protein complex disassembly (GO:0043624)3.24568659
85positive regulation of mast cell activation (GO:0033005)3.24029619
86telomere maintenance via recombination (GO:0000722)3.23376505
87regulation of dendritic cell antigen processing and presentation (GO:0002604)3.22190661
88negative regulation of T-helper cell differentiation (GO:0045623)3.21820581
89negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.21820581
90B cell receptor signaling pathway (GO:0050853)3.20613990
91positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.17171759
92tolerance induction (GO:0002507)3.16506492
93dendritic cell migration (GO:0036336)3.15907754
94negative thymic T cell selection (GO:0045060)3.12243033
95negative T cell selection (GO:0043383)3.09317389
96negative regulation of alpha-beta T cell activation (GO:0046636)3.07500029
97regulation of alpha-beta T cell proliferation (GO:0046640)3.07089772
98definitive hemopoiesis (GO:0060216)3.06638649
99regulation of regulatory T cell differentiation (GO:0045589)3.06577541
100positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.05221582
101negative regulation of cytokine production involved in immune response (GO:0002719)3.04714211
102myeloid leukocyte mediated immunity (GO:0002444)3.03892345
103regulation of leukocyte degranulation (GO:0043300)3.03080713
104regulation of leukocyte mediated cytotoxicity (GO:0001910)2.98768796
105negative regulation of interleukin-6 production (GO:0032715)2.97480718
106regulation of T-helper 2 cell differentiation (GO:0045628)2.97443138
107germinal center formation (GO:0002467)2.97173036
108positive thymic T cell selection (GO:0045059)2.96290616
109platelet dense granule organization (GO:0060155)2.93888004
110antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.93769029
111mast cell activation (GO:0045576)2.91924905
112protein complex disassembly (GO:0043241)2.88069723
113DNA replication initiation (GO:0006270)2.86628411
114mitotic recombination (GO:0006312)2.84473117
115ribosomal large subunit biogenesis (GO:0042273)2.80619081
116* response to interferon-alpha (GO:0035455)2.80210440
117ribonucleoprotein complex biogenesis (GO:0022613)2.77042602
118deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.76901135
119nuclear-transcribed mRNA catabolic process (GO:0000956)2.73271375
120IMP biosynthetic process (GO:0006188)2.72825275
121telomere maintenance via telomere lengthening (GO:0010833)2.72346376
122antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.67883108
123antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.67883108
124macromolecular complex disassembly (GO:0032984)2.66069083
125nucleobase biosynthetic process (GO:0046112)2.64731334
126translation (GO:0006412)2.63679081
127mRNA catabolic process (GO:0006402)2.61539457
128IMP metabolic process (GO:0046040)2.56216671
129DNA unwinding involved in DNA replication (GO:0006268)2.55887783
130Arp2/3 complex-mediated actin nucleation (GO:0034314)2.53086712
131antigen processing and presentation via MHC class Ib (GO:0002475)2.53005415
132protein targeting to membrane (GO:0006612)2.51143854
133RNA catabolic process (GO:0006401)2.50974617
134B cell mediated immunity (GO:0019724)2.50959500
135immunoglobulin mediated immune response (GO:0016064)2.50603486
136nucleotide-excision repair, DNA gap filling (GO:0006297)2.46885636
137folic acid-containing compound biosynthetic process (GO:0009396)2.44340777
138negative regulation of phagocytosis (GO:0050765)2.43959386
139purine nucleobase biosynthetic process (GO:0009113)2.41412078
140pseudouridine synthesis (GO:0001522)2.41402472
141proteasome assembly (GO:0043248)2.41296810
142T cell apoptotic process (GO:0070231)2.40619847
143antigen processing and presentation of endogenous antigen (GO:0019883)2.33205733
144positive regulation of protein import into nucleus, translocation (GO:0033160)2.31783229
145ribosome biogenesis (GO:0042254)2.31252342
146rRNA processing (GO:0006364)2.29875534
147production of molecular mediator involved in inflammatory response (GO:0002532)2.29387989
148pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.28061144
149pteridine-containing compound biosynthetic process (GO:0042559)2.25973403
150endosome to pigment granule transport (GO:0043485)2.24169459
151endosome to melanosome transport (GO:0035646)2.24169459
152antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.21674112
153CENP-A containing nucleosome assembly (GO:0034080)2.21673554
154purine-containing compound salvage (GO:0043101)2.21328505
155antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.19236789
156rRNA metabolic process (GO:0016072)2.18417136
157regulation of protein heterodimerization activity (GO:0043497)2.16898408
158negative regulation of erythrocyte differentiation (GO:0045647)2.14679966
159pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.13890252
160telomere maintenance (GO:0000723)2.12800584
161chromatin remodeling at centromere (GO:0031055)2.12133113
162telomere organization (GO:0032200)2.11830751
163response to peptidoglycan (GO:0032494)2.09481055
164positive regulation of B cell differentiation (GO:0045579)2.09433924
165nucleoside salvage (GO:0043174)2.09139112
166DNA replication checkpoint (GO:0000076)2.06482742
167lymphocyte apoptotic process (GO:0070227)2.05456997
168exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.04705560
169mitotic nuclear envelope disassembly (GO:0007077)2.02970377
170cellular component biogenesis (GO:0044085)2.02165463
1713-UTR-mediated mRNA stabilization (GO:0070935)2.00739532
172establishment of integrated proviral latency (GO:0075713)2.00500624
173pinocytosis (GO:0006907)1.98868927
174viral mRNA export from host cell nucleus (GO:0046784)1.98516937
175response to protozoan (GO:0001562)1.97817119
176daunorubicin metabolic process (GO:0044597)1.97406399
177polyketide metabolic process (GO:0030638)1.97406399
178doxorubicin metabolic process (GO:0044598)1.97406399
179protein localization to kinetochore (GO:0034501)1.97070054
180regulation of antigen processing and presentation of peptide antigen (GO:0002583)1.95572336
181negative regulation of myeloid cell apoptotic process (GO:0033033)1.93364739
182regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)1.93362999
183cellular response to interferon-beta (GO:0035458)1.93186248
184negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)1.90869904
185kinetochore organization (GO:0051383)1.90468840
186DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:001.90114221

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.91070285
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.67350383
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.52585860
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.47236404
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.08145568
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.64289532
7RUNX_20019798_ChIP-Seq_JUKART_Human2.60080684
8SPI1_23127762_ChIP-Seq_K562_Human2.48185117
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.43069880
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.37502429
11UTX_26944678_Chip-Seq_JUKART_Human2.32943259
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.28248730
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.25937039
14SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.25087635
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.22536258
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.21155660
17E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.19489546
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.16713278
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.13487790
20* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.12255861
21TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.08076334
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.05861578
23GABP_17652178_ChIP-ChIP_JURKAT_Human2.00175016
24MAF_26560356_Chip-Seq_TH2_Human1.95271330
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.94833727
26SCL_19346495_ChIP-Seq_HPC-7_Human1.93442133
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.89098190
28JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.88607645
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.87584850
30FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.84561557
31LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.83821792
32ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.83004042
33ETS1_20019798_ChIP-Seq_JURKAT_Human1.82855537
34NELFA_20434984_ChIP-Seq_ESCs_Mouse1.80759781
35XRN2_22483619_ChIP-Seq_HELA_Human1.79832694
36IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.78297720
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.78252821
38FOXM1_23109430_ChIP-Seq_U2OS_Human1.77593026
39CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.77552629
40* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.77546656
41MYB_21317192_ChIP-Seq_ERMYB_Mouse1.75518685
42SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.75082967
43GATA3_27048872_Chip-Seq_THYMUS_Human1.74930723
44MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.72595459
45RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.69750365
46PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.69648023
47CREB1_15753290_ChIP-ChIP_HEK293T_Human1.66936341
48IRF8_21731497_ChIP-ChIP_J774_Mouse1.62772371
49CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.59831640
50VDR_21846776_ChIP-Seq_THP-1_Human1.59264957
51KDM2B_26808549_Chip-Seq_SUP-B15_Human1.58670990
52HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.58611235
53TCF7_22412390_ChIP-Seq_EML_Mouse1.57796171
54* SPI1_23547873_ChIP-Seq_NB4_Human1.57654226
55MYC_22102868_ChIP-Seq_BL_Human1.57602592
56VDR_23849224_ChIP-Seq_CD4+_Human1.56823284
57GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.56818374
58STAT3_1855785_ChIP-Seq_MESCs_Mouse1.56640842
59VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.54857378
60* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.53246234
61THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.52618231
62NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.51149464
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.50123051
64* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.48752364
65CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.48560266
66GATA3_26560356_Chip-Seq_TH2_Human1.47250327
67BCL6_27268052_Chip-Seq_Bcells_Human1.47250178
68* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.46356478
69ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.46079060
70CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.45897553
71SRF_21415370_ChIP-Seq_HL-1_Mouse1.45523487
72KDM2B_26808549_Chip-Seq_DND41_Human1.44490393
73FOXP3_21729870_ChIP-Seq_TREG_Human1.43192372
74DCP1A_22483619_ChIP-Seq_HELA_Human1.41606841
75NOTCH1_21737748_ChIP-Seq_TLL_Human1.41272393
76PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.40862999
77SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.37084956
78* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.36903429
79KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.36207946
80STAT6_21828071_ChIP-Seq_BEAS2B_Human1.35625154
81VDR_24787735_ChIP-Seq_THP-1_Human1.33903858
82CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.33064562
83STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.32752208
84NANOG_18555785_ChIP-Seq_MESCs_Mouse1.32190041
85GATA1_19941827_ChIP-Seq_MEL_Mouse1.31437158
86AR_21909140_ChIP-Seq_LNCAP_Human1.31004363
87ELK1_19687146_ChIP-ChIP_HELA_Human1.30379562
88LXR_22292898_ChIP-Seq_THP-1_Human1.29345423
89TP63_17297297_ChIP-ChIP_HaCaT_Human1.27975754
90TTF2_22483619_ChIP-Seq_HELA_Human1.27599770
91GABP_19822575_ChIP-Seq_HepG2_Human1.27184606
92E2F1_21310950_ChIP-Seq_MCF-7_Human1.26243480
93VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.25743974
94* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.25038430
95BCOR_27268052_Chip-Seq_Bcells_Human1.24628284
96TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.23560143
97SMAD_19615063_ChIP-ChIP_OVARY_Human1.22926029
98PU.1_20513432_ChIP-Seq_Bcells_Mouse1.22679692
99ZFX_18555785_ChIP-Seq_MESCs_Mouse1.22666888
100PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22394487
101CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.21721071
102Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.20773138
103HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.19295864
104CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.18914122
105CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18141277
106* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.17937062
107STAT4_19710469_ChIP-ChIP_TH1__Mouse1.17775827
108IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.17347151
109KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.17245706
110PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17141296
111TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16762675
112FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16698020
113NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.16613971
114RUNX1_22412390_ChIP-Seq_EML_Mouse1.15478084
115GATA1_22025678_ChIP-Seq_K562_Human1.15346314
116BRD4_27068464_Chip-Seq_AML-cells_Mouse1.15086122
117* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.12962214
118IKZF1_21737484_ChIP-ChIP_HCT116_Human1.12650666
119POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.12430357
120GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.11863839
121VDR_24763502_ChIP-Seq_THP-1_Human1.11516840
122PPARA_22158963_ChIP-Seq_LIVER_Mouse1.10405750
123SPI1_20517297_ChIP-Seq_HL60_Human1.09382698
124* RXR_22158963_ChIP-Seq_LIVER_Mouse1.07990021
125RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.07496267
126ELF1_20517297_ChIP-Seq_JURKAT_Human1.07308490
127MYCN_18555785_ChIP-Seq_MESCs_Mouse1.06709147
128SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06538703
129PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06465698
130CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.05215056
131CIITA_25753668_ChIP-Seq_RAJI_Human1.03889069
132TFEB_21752829_ChIP-Seq_HELA_Human1.03425577
133* MAF_26560356_Chip-Seq_TH1_Human1.01780870
134ELK3_25401928_ChIP-Seq_HUVEC_Human1.00314566
135PU_27001747_Chip-Seq_BMDM_Mouse0.99400367
136* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.98652294
137EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.97699216
138GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97378266
139RARG_19884340_ChIP-ChIP_MEFs_Mouse0.97311145
140SA1_27219007_Chip-Seq_ERYTHROID_Human0.97106826
141GATA1_19941826_ChIP-Seq_K562_Human0.96599669
142* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.95600343
143MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.95353258
144MYB_26560356_Chip-Seq_TH2_Human0.95176225
145CTCF_27219007_Chip-Seq_ERYTHROID_Human0.94948373
146TCF3_18692474_ChIP-Seq_MEFs_Mouse0.94811695
147* GATA2_21666600_ChIP-Seq_HMVEC_Human0.94790249
148GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94598487
149IRF8_27001747_Chip-Seq_BMDM_Mouse0.94425741
150SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93937012
151LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.93635134
152MYB_26560356_Chip-Seq_TH1_Human0.93227147
153RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.92213179
154STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.90738400
155PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90719269
156P300_27268052_Chip-Seq_Bcells_Human0.90421653
157CTCF_26484167_Chip-Seq_Bcells_Mouse0.90119318
158RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89335993
159KDM2B_26808549_Chip-Seq_JURKAT_Human0.88715959
160FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87960446

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.23697985
2MP0006082_CNS_inflammation2.74222726
3MP0002396_abnormal_hematopoietic_system2.67744256
4MP0001835_abnormal_antigen_presentation2.24707503
5MP0001545_abnormal_hematopoietic_system2.24386419
6MP0005397_hematopoietic_system_phenotyp2.24386419
7MP0003724_increased_susceptibility_to2.20544684
8MP0003693_abnormal_embryo_hatching2.12318905
9MP0003436_decreased_susceptibility_to2.11995495
10MP0003806_abnormal_nucleotide_metabolis2.05822361
11MP0006054_spinal_hemorrhage2.01456817
12MP0009785_altered_susceptibility_to1.99657347
13MP0008438_abnormal_cutaneous_collagen1.96387082
14MP0003186_abnormal_redox_activity1.95745235
15MP0002277_abnormal_respiratory_mucosa1.94203396
16MP0004808_abnormal_hematopoietic_stem1.89596464
17MP0008007_abnormal_cellular_replicative1.86549734
18MP0003866_abnormal_defecation1.78826599
19MP0001853_heart_inflammation1.77218896
20MP0000685_abnormal_immune_system1.73635556
21MP0002148_abnormal_hypersensitivity_rea1.71727307
22MP0010352_gastrointestinal_tract_polyps1.68177857
23MP0000490_abnormal_crypts_of1.67792903
24MP0004957_abnormal_blastocyst_morpholog1.67096361
25MP0010368_abnormal_lymphatic_system1.61460804
26MP0010094_abnormal_chromosome_stability1.60949060
27MP0005025_abnormal_response_to1.60820492
28MP0003077_abnormal_cell_cycle1.60685443
29MP0005464_abnormal_platelet_physiology1.59556142
30MP0009278_abnormal_bone_marrow1.57870389
31MP0008057_abnormal_DNA_replication1.57214596
32MP0000343_altered_response_to1.55086352
33MP0008260_abnormal_autophagy1.50013857
34MP0002419_abnormal_innate_immunity1.47392861
35MP0005023_abnormal_wound_healing1.44736648
36MP0009379_abnormal_foot_pigmentation1.44713701
37MP0003279_aneurysm1.41640827
38MP0009333_abnormal_splenocyte_physiolog1.38505836
39MP0003183_abnormal_peptide_metabolism1.37910484
40MP0010155_abnormal_intestine_physiology1.37383959
41MP0003111_abnormal_nucleus_morphology1.37222419
42MP0000465_gastrointestinal_hemorrhage1.36480114
43MP0002166_altered_tumor_susceptibility1.31101083
44MP0000858_altered_metastatic_potential1.29423582
45MP0001851_eye_inflammation1.27958872
46MP0005503_abnormal_tendon_morphology1.27423896
47MP0003705_abnormal_hypodermis_morpholog1.26858951
48MP0004510_myositis1.25472777
49MP0004883_abnormal_blood_vessel1.25161035
50MP0005000_abnormal_immune_tolerance1.24485327
51MP0002452_abnormal_antigen_presenting1.24011941
52MP0008058_abnormal_DNA_repair1.24003477
53MP0004381_abnormal_hair_follicle1.23537799
54MP0003075_altered_response_to1.23394242
55MP0001533_abnormal_skeleton_physiology1.21745813
56MP0002405_respiratory_system_inflammati1.21041516
57MP0003566_abnormal_cell_adhesion1.20961932
58MP0003191_abnormal_cellular_cholesterol1.20596383
59MP0001800_abnormal_humoral_immune1.20490843
60MP0002398_abnormal_bone_marrow1.19288488
61MP0000689_abnormal_spleen_morphology1.18313116
62MP0009840_abnormal_foam_cell1.17105560
63MP0005671_abnormal_response_to1.16869609
64MP0005275_abnormal_skin_tensile1.15858454
65MP0002722_abnormal_immune_system1.14011620
66MP0002132_abnormal_respiratory_system1.13935880
67MP0002723_abnormal_immune_serum1.12112643
68MP0008469_abnormal_protein_level1.10829961
69MP0002420_abnormal_adaptive_immunity1.10638127
70MP0002877_abnormal_melanocyte_morpholog1.10050831
71MP0001819_abnormal_immune_cell1.09947227
72MP0003828_pulmonary_edema1.09237774
73MP0002006_tumorigenesis1.09178429
74MP0005164_abnormal_response_to1.07299276
75MP0001845_abnormal_inflammatory_respons1.07258365
76MP0002429_abnormal_blood_cell1.07053052
77MP0002998_abnormal_bone_remodeling1.06683740
78MP0002138_abnormal_hepatobiliary_system1.05620351
79MP0005310_abnormal_salivary_gland1.04890207
80MP0002019_abnormal_tumor_incidence1.04173347
81MP0005166_decreased_susceptibility_to1.03055283
82MP0000716_abnormal_immune_system1.03007549
83MP0005174_abnormal_tail_pigmentation1.01292904
84MP0010307_abnormal_tumor_latency1.00898374
85MP0003567_abnormal_fetal_cardiomyocyte0.98195936
86MP0003172_abnormal_lysosome_physiology0.97907417
87MP0005319_abnormal_enzyme/_coenzyme0.95878107
88MP0003763_abnormal_thymus_physiology0.95586789
89MP0001790_abnormal_immune_system0.94504682
90MP0005387_immune_system_phenotype0.94504682
91MP0001879_abnormal_lymphatic_vessel0.93216718
92MP0002933_joint_inflammation0.92838929
93MP0005451_abnormal_body_composition0.92806784
94MP0001663_abnormal_digestive_system0.92768359
95MP0005075_abnormal_melanosome_morpholog0.92584750
96MP0005365_abnormal_bile_salt0.92218222
97MP0003448_altered_tumor_morphology0.91749220
98MP0000598_abnormal_liver_morphology0.90356418
99MP0005390_skeleton_phenotype0.89739778
100MP0009764_decreased_sensitivity_to0.86803548
101MP0000350_abnormal_cell_proliferation0.85333363
102MP0008004_abnormal_stomach_pH0.85015571
103MP0009763_increased_sensitivity_to0.83908648
104MP0000313_abnormal_cell_death0.83533732
105MP0003943_abnormal_hepatobiliary_system0.83020206
106MP0001873_stomach_inflammation0.82778309
107MP0003878_abnormal_ear_physiology0.82775005
108MP0005377_hearing/vestibular/ear_phenot0.82775005
109MP0003786_premature_aging0.81242289
110MP0001986_abnormal_taste_sensitivity0.80996775
111MP0005084_abnormal_gallbladder_morpholo0.79501696
112MP0005360_urolithiasis0.77480751
113MP0002060_abnormal_skin_morphology0.76950340
114MP0009765_abnormal_xenobiotic_induced0.76490975
115MP0008875_abnormal_xenobiotic_pharmacok0.75966439
116MP0001915_intracranial_hemorrhage0.75728481
117MP0003045_fibrosis0.75057804
118MP0005085_abnormal_gallbladder_physiolo0.74614546
119MP0000703_abnormal_thymus_morphology0.73147472
120MP0001764_abnormal_homeostasis0.73005679
121MP0000767_abnormal_smooth_muscle0.72939932
122MP0010030_abnormal_orbit_morphology0.72844786
123MP0004947_skin_inflammation0.71567200
124MP0009697_abnormal_copulation0.70358001
125MP0008932_abnormal_embryonic_tissue0.70215296
126MP0003011_delayed_dark_adaptation0.69512267
127MP0003300_gastrointestinal_ulcer0.69478167
128MP0000249_abnormal_blood_vessel0.68712013
129MP0003690_abnormal_glial_cell0.68092226
130MP0005083_abnormal_biliary_tract0.67784517
131MP0003795_abnormal_bone_structure0.67176586
132MP0004858_abnormal_nervous_system0.61000662
133MP0002653_abnormal_ependyma_morphology0.60650557
134MP0008874_decreased_physiological_sensi0.57395731
135MP0001542_abnormal_bone_strength0.56342727
136MP0002254_reproductive_system_inflammat0.53924984
137MP0001958_emphysema0.52328672
138MP0002928_abnormal_bile_duct0.52023309
139MP0008873_increased_physiological_sensi0.51733852
140MP0005381_digestive/alimentary_phenotyp0.49349808
141MP0003252_abnormal_bile_duct0.47249368

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)5.48353200
2Retrobulbar optic neuritis (HP:0100654)5.45079956
3Optic neuritis (HP:0100653)5.45079956
4Hypochromic microcytic anemia (HP:0004840)4.92612708
5Chronic obstructive pulmonary disease (HP:0006510)4.58204844
6Obstructive lung disease (HP:0006536)4.58204844
7Abnormal delayed hypersensitivity skin test (HP:0002963)4.50006417
8Recurrent fungal infections (HP:0002841)4.30227119
9Meningitis (HP:0001287)4.30194458
10Gastrointestinal infarctions (HP:0005244)4.27499073
11Thrombocytosis (HP:0001894)4.24755779
12Reticulocytopenia (HP:0001896)4.15954320
13Encephalitis (HP:0002383)4.10290511
14Aplastic anemia (HP:0001915)4.07832885
15Hypochromic anemia (HP:0001931)4.06143974
16Abnormality of cells of the erythroid lineage (HP:0012130)4.02855809
17Abnormal number of erythroid precursors (HP:0012131)3.98765443
18Keratoconjunctivitis sicca (HP:0001097)3.90583469
19Increased IgE level (HP:0003212)3.87495283
20Recurrent skin infections (HP:0001581)3.87082135
21Keratoconjunctivitis (HP:0001096)3.72697931
22Urticaria (HP:0001025)3.68577122
23Vasculitis (HP:0002633)3.65657773
24Recurrent cutaneous fungal infections (HP:0011370)3.58132867
25Chronic mucocutaneous candidiasis (HP:0002728)3.58132867
26Increased IgM level (HP:0003496)3.36746520
27Gingivitis (HP:0000230)3.36719650
28Elevated erythrocyte sedimentation rate (HP:0003565)3.31607915
29Chest pain (HP:0100749)3.28158371
30Petechiae (HP:0000967)3.23413874
31Episodic fever (HP:0001954)3.21622008
32Pulmonary infiltrates (HP:0002113)3.13872695
33Anorexia (HP:0002039)3.12328505
34Hemoptysis (HP:0002105)3.09352469
35Protrusio acetabuli (HP:0003179)3.09124811
36Abnormality of T cell number (HP:0011839)3.02688624
37Leukocytosis (HP:0001974)3.01981764
38Reduced antithrombin III activity (HP:0001976)2.99356818
39Panhypogammaglobulinemia (HP:0003139)2.97933454
40Abnormality of T cells (HP:0002843)2.97351074
41T lymphocytopenia (HP:0005403)2.97103859
42Myositis (HP:0100614)2.91748859
43Granulocytopenia (HP:0001913)2.83536718
44Systemic lupus erythematosus (HP:0002725)2.76567410
45Pulmonary embolism (HP:0002204)2.74488528
46Prolonged bleeding time (HP:0003010)2.72509500
47Hypergammaglobulinemia (HP:0010702)2.71098605
48Recurrent abscess formation (HP:0002722)2.70918941
49Arterial thrombosis (HP:0004420)2.69736117
50Inflammation of the large intestine (HP:0002037)2.69509156
51Type I transferrin isoform profile (HP:0003642)2.67743104
52Oral leukoplakia (HP:0002745)2.64405121
53Gastrointestinal inflammation (HP:0004386)2.61760522
54Vertebral compression fractures (HP:0002953)2.58288817
55Abnormality of the pleura (HP:0002103)2.57550920
56Pallor (HP:0000980)2.56419623
57Lymphopenia (HP:0001888)2.55548524
58Recurrent viral infections (HP:0004429)2.53808554
59Osteomyelitis (HP:0002754)2.45159022
60Eosinophilia (HP:0001880)2.43468325
61Abnormality of cells of the lymphoid lineage (HP:0012140)2.43290186
62Recurrent bacterial skin infections (HP:0005406)2.43159862
63Sepsis (HP:0100806)2.41272262
64Gangrene (HP:0100758)2.41011675
65Biconcave vertebral bodies (HP:0004586)2.40889055
66Abnormality of the peritoneum (HP:0002585)2.36533533
67Epistaxis (HP:0000421)2.36514393
68IgM deficiency (HP:0002850)2.35696512
69Spontaneous hematomas (HP:0007420)2.34838361
70Macrocytic anemia (HP:0001972)2.33991887
71Hepatosplenomegaly (HP:0001433)2.33639258
72Amyloidosis (HP:0011034)2.32984234
73Abnormality of the pericardium (HP:0001697)2.30704829
74Selective tooth agenesis (HP:0001592)2.29902499
75Agammaglobulinemia (HP:0004432)2.28708722
76Premature loss of primary teeth (HP:0006323)2.24984276
77Purpura (HP:0000979)2.24319515
7811 pairs of ribs (HP:0000878)2.22451422
79Abnormality of pyrimidine metabolism (HP:0004353)2.21790947
80Colon cancer (HP:0003003)2.21223198
81Abnormal platelet function (HP:0011869)2.20929257
82Impaired platelet aggregation (HP:0003540)2.20929257
83Recurrent bronchitis (HP:0002837)2.20659365
84Skin ulcer (HP:0200042)2.19974032
85Aplasia/Hypoplasia of the sacrum (HP:0008517)2.19941249
86Nasal polyposis (HP:0100582)2.16197545
87Acne (HP:0001061)2.15630656
88Glomerulopathy (HP:0100820)2.15269588
89Poor head control (HP:0002421)2.14236201
90Orchitis (HP:0100796)2.12726942
91Toxemia of pregnancy (HP:0100603)2.12510853
92Acute hepatic failure (HP:0006554)2.11320890
93Keratitis (HP:0000491)2.10987256
94Gingival bleeding (HP:0000225)2.07987568
95Skin rash (HP:0000988)2.05838191
96Abnormality of eosinophils (HP:0001879)2.03809533
97Eczematoid dermatitis (HP:0000976)2.03649679
98Abnormality of monocarboxylic acid metabolism (HP:0010996)2.00868400
99Beaking of vertebral bodies (HP:0004568)2.00735870
100Autoimmune hemolytic anemia (HP:0001890)2.00303671
101Cervical subluxation (HP:0003308)1.99979835
102Abnormality of the endocardium (HP:0004306)1.99630047
103Vertigo (HP:0002321)1.98114495
104Vacuolated lymphocytes (HP:0001922)1.96746177
105Abnormality of T cell physiology (HP:0011840)1.96218430
106Recurrent gram-negative bacterial infections (HP:0005420)1.96169440
107Peritonitis (HP:0002586)1.95933534
108Abnormality of complement system (HP:0005339)1.95621301
109Abnormal platelet volume (HP:0011876)1.94968091
110Hypertensive crisis (HP:0100735)1.94408641
111Myelodysplasia (HP:0002863)1.93729594
112Recurrent pneumonia (HP:0006532)1.91819792
113Periodontitis (HP:0000704)1.91077484
114IgG deficiency (HP:0004315)1.88725614
115Chronic otitis media (HP:0000389)1.88654361
116Abnormal protein glycosylation (HP:0012346)1.87901992
117Abnormal glycosylation (HP:0012345)1.87901992
118Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.87901992
119Abnormal protein N-linked glycosylation (HP:0012347)1.87901992
120Nonimmune hydrops fetalis (HP:0001790)1.87893062
121Multiple enchondromatosis (HP:0005701)1.87374847
122Glomerulonephritis (HP:0000099)1.87089313
123Recurrent lower respiratory tract infections (HP:0002783)1.85749308
124Absent rod-and cone-mediated responses on ERG (HP:0007688)1.85478086
125Abnormality of the anterior horn cell (HP:0006802)1.85379339
126Degeneration of anterior horn cells (HP:0002398)1.85379339
127Spinal cord lesions (HP:0100561)1.84793393
128Syringomyelia (HP:0003396)1.84793393
129Joint swelling (HP:0001386)1.84510350
130Ankle contracture (HP:0006466)1.84314498
131Mediastinal lymphadenopathy (HP:0100721)1.83997075
132Polycythemia (HP:0001901)1.83391708
133Osteolytic defects of the hand bones (HP:0009699)1.82717075
134Osteolytic defects of the phalanges of the hand (HP:0009771)1.82717075
135Microretrognathia (HP:0000308)1.82322222
136Nausea (HP:0002018)1.81528874
137Interstitial pulmonary disease (HP:0006530)1.80988120
138Complement deficiency (HP:0004431)1.80424027
139Abnormality of the prostate (HP:0008775)1.79501033
140Cellulitis (HP:0100658)1.79156273
141Autoimmune thrombocytopenia (HP:0001973)1.78859056
142Pancytopenia (HP:0001876)1.76950067
143Acute myeloid leukemia (HP:0004808)1.75993087
144Agnosia (HP:0010524)1.75171693
145Increased mean platelet volume (HP:0011877)1.74720538
146Birth length less than 3rd percentile (HP:0003561)1.73466168
147Increased serum ferritin (HP:0003281)1.73295949
148Decreased activity of mitochondrial respiratory chain (HP:0008972)1.71372198
149Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.71372198
150Amaurosis fugax (HP:0100576)1.70946101
151Generalized aminoaciduria (HP:0002909)1.70595561
152Abnormality of the intrinsic pathway (HP:0010989)1.70225433
153Sparse eyelashes (HP:0000653)1.69956654
154Joint hemorrhage (HP:0005261)1.69560156
155Microcytic anemia (HP:0001935)1.69171888
156Pustule (HP:0200039)1.68081362
157Rough bone trabeculation (HP:0100670)1.67853225
158Muscle fiber atrophy (HP:0100295)1.67441144
159Abnormality of the heme biosynthetic pathway (HP:0010472)1.66875257
160Abnormality of the nasal mucosa (HP:0000433)1.66730754
161Abnormality of the common coagulation pathway (HP:0010990)1.65782940
162Abnormality of iron homeostasis (HP:0011031)1.63392425
163Trismus (HP:0000211)1.62524289
164Thrombophlebitis (HP:0004418)1.61501804
165Abnormality of macrophages (HP:0004311)1.61444553
166Abnormality of reticulocytes (HP:0004312)1.59594108
167Abnormal hemoglobin (HP:0011902)1.59295462
168Abnormality of aromatic amino acid family metabolism (HP:0004338)1.56615718
169Mesangial abnormality (HP:0001966)1.54425204
170Menorrhagia (HP:0000132)1.52530218
171Esophageal neoplasm (HP:0100751)1.51837828
172Neoplasm of head and neck (HP:0012288)1.51837828

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.61216924
2TNK22.86814564
3NME22.86566899
4PIM22.85272064
5CSK2.75790240
6GRK62.74174015
7FES2.73218992
8WEE12.60946557
9ERN12.53464287
10EPHB12.36320450
11FLT32.26929542
12TGFBR12.26391633
13KIT2.08106851
14KDR2.01243034
15HCK1.87298995
16MAP2K31.87229588
17BUB11.78434388
18RPS6KB21.75254161
19TGFBR21.71010279
20BCKDK1.68834945
21BTK1.68625535
22TAOK11.67340325
23RPS6KA41.65274319
24PAK41.64669610
25TEC1.59077788
26STK161.56771934
27TYK21.52175224
28CDK71.51632828
29TBK11.50803536
30TIE11.48045599
31VRK11.47918399
32EIF2AK11.46931051
33BLK1.46455374
34ACVR1B1.45514846
35LRRK21.43665688
36FGR1.42350009
37MAP4K11.41490100
38PIM11.35837914
39MAPKAPK31.34962793
40CDC71.33944284
41LCK1.32583550
42IRAK41.32179943
43SIK31.31556333
44JAK21.31324037
45JAK11.30844282
46MAP3K131.30784508
47JAK31.30775890
48EEF2K1.30277730
49BRSK21.29442843
50IKBKB1.29114098
51MATK1.25809620
52ITK1.25809589
53SCYL21.25194510
54PKN21.23354426
55EIF2AK31.20523182
56MAP3K141.18318029
57MYLK1.17304202
58DYRK31.16100147
59IRAK31.16008751
60MAP3K111.15443174
61ZAP701.14940445
62MAP3K11.13735122
63PRPF4B1.12360625
64CDK191.11667358
65PRKD21.09118257
66TESK21.06253243
67CDK81.04548879
68MAP3K31.02626677
69MKNK11.02493071
70NEK21.02362618
71MARK30.99961457
72ATR0.98547876
73CSF1R0.98415728
74IKBKE0.97416583
75PTK60.96678423
76PASK0.96559213
77STK100.94240904
78SRPK10.92466060
79ZAK0.92418566
80CDK60.89737552
81CDK40.87976287
82AURKB0.86007811
83ABL20.83115100
84TESK10.82401903
85PIK3CG0.81974572
86KSR20.80072053
87CHUK0.79912573
88PRKG20.77315586
89NEK90.76972834
90PTK2B0.75799743
91IRAK10.75221787
92EIF2AK20.74953991
93MAP3K80.74695950
94STK40.73953639
95PDK10.73271425
96BMPR20.71729480
97SIK20.71561541
98MARK20.71521047
99ILK0.71519722
100PRKCQ0.71008291
101TAOK20.70505400
102SMG10.70467030
103PLK40.70380461
104FYN0.69541646
105PLK10.68773879
106NEK10.67996359
107EPHA30.66096535
108LYN0.65326206
109MAP3K70.63261019
110PDPK10.59717080
111TRPM70.59395633
112RPS6KA60.57808760
113MAP3K60.57552240
114TSSK60.56839566
115MAP2K60.53461604
116TRIB30.52445386
117CSNK2A10.52193890
118NLK0.51149368
119MAPKAPK20.51002353
120TAOK30.50794333
121GRK70.49784549
122RPS6KL10.49607939
123RPS6KC10.49607939
124PAK20.49117116
125MAP3K50.48701093
126STK380.47482165
127SYK0.46712118
128MAPK120.46509886
129TLK10.45368188
130FGFR40.45108903
131HIPK20.45058967
132TXK0.44991741
133MAP3K120.44364347
134MAP3K100.44082761
135EPHA20.43855441
136YES10.43128968
137DYRK1B0.42496404
138STK110.41806552
139MAPK110.41801828
140PRKCD0.41214653
141MAPK70.40719413
142MAPK40.40697884
143IRAK20.40274837
144PAK10.40030768
145ADRBK10.39807066
146MAP2K40.39291891
147CDC42BPA0.38886839
148SIK10.38273149
149ALK0.34236370
150DAPK20.32802231
151RAF10.29747492
152PRKD10.28962748
153ABL10.26612492
154PRKCH0.26520161
155PRKCZ0.25764674
156BMX0.24602966

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.95725854
2Ribosome_Homo sapiens_hsa030103.93023612
3Graft-versus-host disease_Homo sapiens_hsa053323.30139043
4Mismatch repair_Homo sapiens_hsa034302.99879115
5Autoimmune thyroid disease_Homo sapiens_hsa053202.99022401
6Primary immunodeficiency_Homo sapiens_hsa053402.96200178
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.86269195
8Type I diabetes mellitus_Homo sapiens_hsa049402.32313795
9Base excision repair_Homo sapiens_hsa034102.31123142
10Proteasome_Homo sapiens_hsa030502.17921703
11Tuberculosis_Homo sapiens_hsa051522.12116841
12B cell receptor signaling pathway_Homo sapiens_hsa046622.09554900
13Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.08398740
14One carbon pool by folate_Homo sapiens_hsa006702.07650564
15Viral myocarditis_Homo sapiens_hsa054161.99408399
16Pyrimidine metabolism_Homo sapiens_hsa002401.92297193
17Homologous recombination_Homo sapiens_hsa034401.89732677
18Spliceosome_Homo sapiens_hsa030401.87665201
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.84183105
20Nucleotide excision repair_Homo sapiens_hsa034201.78110777
21RNA polymerase_Homo sapiens_hsa030201.76094452
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.74842994
23Chemokine signaling pathway_Homo sapiens_hsa040621.68948455
24African trypanosomiasis_Homo sapiens_hsa051431.62137696
25T cell receptor signaling pathway_Homo sapiens_hsa046601.59237596
26Folate biosynthesis_Homo sapiens_hsa007901.56844187
27Staphylococcus aureus infection_Homo sapiens_hsa051501.53749995
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.49249967
29Pentose and glucuronate interconversions_Homo sapiens_hsa000401.46043873
30Phagosome_Homo sapiens_hsa041451.45895561
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.42790507
32Caffeine metabolism_Homo sapiens_hsa002321.41081607
33Legionellosis_Homo sapiens_hsa051341.36524940
34RNA transport_Homo sapiens_hsa030131.35505738
35Leishmaniasis_Homo sapiens_hsa051401.32111364
36Cell cycle_Homo sapiens_hsa041101.31369749
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.25842636
38Herpes simplex infection_Homo sapiens_hsa051681.21061574
39RNA degradation_Homo sapiens_hsa030181.18029038
40Complement and coagulation cascades_Homo sapiens_hsa046101.17252184
41p53 signaling pathway_Homo sapiens_hsa041151.16667148
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.16048198
43Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.15879423
44Rheumatoid arthritis_Homo sapiens_hsa053231.11283870
45Platelet activation_Homo sapiens_hsa046111.09234386
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.07811415
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.07383121
48Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.07308049
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.05899456
50Antigen processing and presentation_Homo sapiens_hsa046121.05454782
51Sulfur relay system_Homo sapiens_hsa041221.03444488
52Non-homologous end-joining_Homo sapiens_hsa034501.03059868
53Hepatitis C_Homo sapiens_hsa051601.02771558
54Protein export_Homo sapiens_hsa030601.02267745
55Glutathione metabolism_Homo sapiens_hsa004801.01877704
56SNARE interactions in vesicular transport_Homo sapiens_hsa041301.00799378
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.00738864
58Pentose phosphate pathway_Homo sapiens_hsa000301.00526026
59Selenocompound metabolism_Homo sapiens_hsa004500.99918484
60Galactose metabolism_Homo sapiens_hsa000520.98784363
61Malaria_Homo sapiens_hsa051440.98413936
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.97556758
63Pertussis_Homo sapiens_hsa051330.97040662
64Salmonella infection_Homo sapiens_hsa051320.93957948
65Measles_Homo sapiens_hsa051620.93916106
66Fanconi anemia pathway_Homo sapiens_hsa034600.90817402
67NF-kappa B signaling pathway_Homo sapiens_hsa040640.90409245
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90046406
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.88873473
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.87049165
71Chemical carcinogenesis_Homo sapiens_hsa052040.85206207
72Other glycan degradation_Homo sapiens_hsa005110.83990362
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82155373
74Shigellosis_Homo sapiens_hsa051310.80347262
75Endocytosis_Homo sapiens_hsa041440.79175163
76Toll-like receptor signaling pathway_Homo sapiens_hsa046200.79138728
77Glycosaminoglycan degradation_Homo sapiens_hsa005310.78389010
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.76560221
79Purine metabolism_Homo sapiens_hsa002300.75521394
80Biosynthesis of amino acids_Homo sapiens_hsa012300.75270873
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75077005
82N-Glycan biosynthesis_Homo sapiens_hsa005100.74867521
83Non-small cell lung cancer_Homo sapiens_hsa052230.74770554
84Apoptosis_Homo sapiens_hsa042100.74297909
85Intestinal immune network for IgA production_Homo sapiens_hsa046720.72209199
86Hematopoietic cell lineage_Homo sapiens_hsa046400.71851256
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70072147
88Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.69638794
89Epstein-Barr virus infection_Homo sapiens_hsa051690.69021897
90Regulation of autophagy_Homo sapiens_hsa041400.68187006
91Influenza A_Homo sapiens_hsa051640.68086928
92Systemic lupus erythematosus_Homo sapiens_hsa053220.68007579
93Pancreatic cancer_Homo sapiens_hsa052120.67815660
94Asthma_Homo sapiens_hsa053100.67536778
95Acute myeloid leukemia_Homo sapiens_hsa052210.65698878
96NOD-like receptor signaling pathway_Homo sapiens_hsa046210.64237210
97Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63309872
98Small cell lung cancer_Homo sapiens_hsa052220.63217651
99Jak-STAT signaling pathway_Homo sapiens_hsa046300.62755545
100Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60310171
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59423981
102Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59193404
103Cyanoamino acid metabolism_Homo sapiens_hsa004600.59149507
104Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59061264
105Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58615002
106Thyroid cancer_Homo sapiens_hsa052160.58339086
107VEGF signaling pathway_Homo sapiens_hsa043700.58160644
108Steroid hormone biosynthesis_Homo sapiens_hsa001400.57790963
109Toxoplasmosis_Homo sapiens_hsa051450.57236976
110Hepatitis B_Homo sapiens_hsa051610.57125804
111Viral carcinogenesis_Homo sapiens_hsa052030.55945446
112Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.54311868
113Arachidonic acid metabolism_Homo sapiens_hsa005900.53207013
114TNF signaling pathway_Homo sapiens_hsa046680.52785089
115Basal transcription factors_Homo sapiens_hsa030220.52659170
116Peroxisome_Homo sapiens_hsa041460.51349191
117Starch and sucrose metabolism_Homo sapiens_hsa005000.50880543
118Renin-angiotensin system_Homo sapiens_hsa046140.50352540
1192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49608524
120Retinol metabolism_Homo sapiens_hsa008300.48784148
121Osteoclast differentiation_Homo sapiens_hsa043800.48732423
122HTLV-I infection_Homo sapiens_hsa051660.48478038
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.46991865
124Carbon metabolism_Homo sapiens_hsa012000.45830610
125Prolactin signaling pathway_Homo sapiens_hsa049170.45039584
126Fatty acid degradation_Homo sapiens_hsa000710.44986748
127Phospholipase D signaling pathway_Homo sapiens_hsa040720.43247668
128Amoebiasis_Homo sapiens_hsa051460.43246978
129Allograft rejection_Homo sapiens_hsa053300.42165298
130Adipocytokine signaling pathway_Homo sapiens_hsa049200.42106025
131Chronic myeloid leukemia_Homo sapiens_hsa052200.42103320
132Leukocyte transendothelial migration_Homo sapiens_hsa046700.41337334
133Fructose and mannose metabolism_Homo sapiens_hsa000510.40802705
134Lysosome_Homo sapiens_hsa041420.40790498
135Glycerophospholipid metabolism_Homo sapiens_hsa005640.39910748
136Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.38411852
137Neurotrophin signaling pathway_Homo sapiens_hsa047220.36040054
138Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34297303
139Notch signaling pathway_Homo sapiens_hsa043300.33836042
140Rap1 signaling pathway_Homo sapiens_hsa040150.33619814
141FoxO signaling pathway_Homo sapiens_hsa040680.33464367
142AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.30470298
143Collecting duct acid secretion_Homo sapiens_hsa049660.30091754
144Renal cell carcinoma_Homo sapiens_hsa052110.30070899
145HIF-1 signaling pathway_Homo sapiens_hsa040660.29972821
146MAPK signaling pathway_Homo sapiens_hsa040100.28577794
147Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.26504574
148Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26300737
149Choline metabolism in cancer_Homo sapiens_hsa052310.25362070
150Insulin resistance_Homo sapiens_hsa049310.24914486
151Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.23342466
152Colorectal cancer_Homo sapiens_hsa052100.18538607
153Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.17514609
154Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.14168335
155alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.13196708

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