IFITM3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an interferon-induced membrane protein that helps confer immunity to influenza A H1N1 virus, West Nile virus, and dengue virus. Two transcript variants, only one of them protein-coding, have been found for this gene. Another variant encoding an N-terminally truncated isoform has been reported, but the full-length nature of this variant has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.20683886
2* response to interferon-alpha (GO:0035455)4.99612207
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.66516687
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.66516687
5* response to interferon-beta (GO:0035456)4.57144165
6antigen processing and presentation of endogenous antigen (GO:0019883)4.37225970
7* type I interferon signaling pathway (GO:0060337)4.36152663
8* cellular response to type I interferon (GO:0071357)4.36152663
9* response to type I interferon (GO:0034340)4.33796004
10leukocyte migration involved in inflammatory response (GO:0002523)4.26050563
11positive regulation of interferon-alpha production (GO:0032727)4.12223621
12immunoglobulin mediated immune response (GO:0016064)3.94467725
13regulation of interferon-alpha production (GO:0032647)3.92276109
14detection of bacterium (GO:0016045)3.85601693
15ribosomal small subunit assembly (GO:0000028)3.62651908
16positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.59821812
17extracellular fibril organization (GO:0043206)3.56857401
18fibril organization (GO:0097435)3.55448384
19response to peptidoglycan (GO:0032494)3.34913202
20* negative regulation of viral genome replication (GO:0045071)3.34822126
21antigen processing and presentation via MHC class Ib (GO:0002475)3.33955774
22positive regulation of interleukin-8 secretion (GO:2000484)3.28582554
23T-helper 1 type immune response (GO:0042088)3.24391936
24modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.24194638
25modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.24194638
26positive regulation by organism of defense response of other organism involved in symbiotic interact3.24194638
27modulation by symbiont of host immune response (GO:0052553)3.24194638
28positive regulation by symbiont of host defense response (GO:0052509)3.24194638
29modulation by symbiont of host defense response (GO:0052031)3.24194638
30positive regulation of natural killer cell differentiation (GO:0032825)3.22280087
31B cell mediated immunity (GO:0019724)3.21052211
32regulation of interferon-beta biosynthetic process (GO:0045357)3.19323186
33neutrophil activation involved in immune response (GO:0002283)3.17532402
34* regulation of viral entry into host cell (GO:0046596)3.14654222
35interferon-gamma-mediated signaling pathway (GO:0060333)3.14629422
36leukocyte aggregation (GO:0070486)3.13677577
37negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.12585761
38negative regulation of cell killing (GO:0031342)3.12585761
39positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.12131382
40cellular response to interferon-beta (GO:0035458)3.08752737
41regulation of interleukin-8 secretion (GO:2000482)3.08361128
42chronic inflammatory response (GO:0002544)3.00939924
43regulation of T-helper 1 cell differentiation (GO:0045625)2.98705932
44detection of biotic stimulus (GO:0009595)2.96385096
45defense response to protozoan (GO:0042832)2.92765358
46mature B cell differentiation involved in immune response (GO:0002313)2.90365852
47production of molecular mediator involved in inflammatory response (GO:0002532)2.90318498
48regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.89720488
49response to protozoan (GO:0001562)2.88468383
50keratan sulfate catabolic process (GO:0042340)2.88029070
51negative regulation of complement activation (GO:0045916)2.87858330
52cellular response to virus (GO:0098586)2.85843336
53cell migration involved in heart development (GO:0060973)2.83299163
54fibrinolysis (GO:0042730)2.83129091
55positive regulation of interferon-beta production (GO:0032728)2.81764227
56basement membrane organization (GO:0071711)2.80350903
57cellular response to exogenous dsRNA (GO:0071360)2.79996504
58regulation of natural killer cell differentiation (GO:0032823)2.79371791
59phospholipid scrambling (GO:0017121)2.79361706
60lipopolysaccharide-mediated signaling pathway (GO:0031663)2.78416016
61positive regulation of antigen processing and presentation (GO:0002579)2.78358319
62regulation of type I interferon-mediated signaling pathway (GO:0060338)2.75261026
63skin morphogenesis (GO:0043589)2.74025071
64type B pancreatic cell proliferation (GO:0044342)2.73916086
65definitive hemopoiesis (GO:0060216)2.73753869
66negative regulation of innate immune response (GO:0045824)2.70598389
67regulation of RIG-I signaling pathway (GO:0039535)2.70438520
68positive regulation of Cdc42 GTPase activity (GO:0043089)2.69735419
69negative regulation of protein activation cascade (GO:2000258)2.66951039
70myeloid dendritic cell differentiation (GO:0043011)2.66009711
71barbed-end actin filament capping (GO:0051016)2.65571491
72platelet dense granule organization (GO:0060155)2.65252962
73negative regulation of myeloid cell apoptotic process (GO:0033033)2.64496110
74positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.64043532
75viral transcription (GO:0019083)2.64040603
76myeloid dendritic cell activation (GO:0001773)2.63603568
77negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.63266130
78complement activation (GO:0006956)2.63227611
79protein maturation by protein folding (GO:0022417)2.63050631
80complement activation, classical pathway (GO:0006958)2.62007896
81antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.60069786
82negative regulation of glycoprotein metabolic process (GO:1903019)2.59346241
83tooth mineralization (GO:0034505)2.58840038
84detection of molecule of bacterial origin (GO:0032490)2.57971749
85antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.56146558
86response to host (GO:0075136)2.55752885
87response to host defenses (GO:0052200)2.55752885
88response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.55752885
89cellular response to interferon-alpha (GO:0035457)2.55215029
90complement activation, alternative pathway (GO:0006957)2.54510830
91regulation of antigen processing and presentation (GO:0002577)2.54262304
92positive regulation of T cell migration (GO:2000406)2.53540271
93endosome to melanosome transport (GO:0035646)2.53250582
94endosome to pigment granule transport (GO:0043485)2.53250582
95cellular response to zinc ion (GO:0071294)2.51705378
96protein carboxylation (GO:0018214)2.49881985
97peptidyl-glutamic acid carboxylation (GO:0017187)2.49881985
98regulation of heterotypic cell-cell adhesion (GO:0034114)2.49454333
99pinocytosis (GO:0006907)2.49048934
100positive regulation of lymphocyte migration (GO:2000403)2.48286843
101negative regulation of humoral immune response (GO:0002921)2.46865672
102translational termination (GO:0006415)2.46828244
103regulation of T cell migration (GO:2000404)2.45360056
104response to muramyl dipeptide (GO:0032495)2.44657273
105* response to interferon-gamma (GO:0034341)2.44142381
106cellular response to interferon-gamma (GO:0071346)2.42414065
107positive regulation of hemostasis (GO:1900048)2.42063310
108positive regulation of blood coagulation (GO:0030194)2.42063310
109endothelial tube morphogenesis (GO:0061154)2.42014182
110morphogenesis of an endothelium (GO:0003159)2.42014182
111regulation of interleukin-8 biosynthetic process (GO:0045414)2.40297410
112opsonization (GO:0008228)2.39862313
113positive regulation of coagulation (GO:0050820)2.37957364
114positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.37457461
115dendritic cell differentiation (GO:0097028)2.35889879
116response to host immune response (GO:0052572)2.35486553
117response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.35486553
118positive regulation of respiratory burst (GO:0060267)2.35086015
119detection of external biotic stimulus (GO:0098581)2.34703490
120negative regulation of interleukin-12 production (GO:0032695)2.34350600
121* negative regulation of viral process (GO:0048525)2.33819316
122lymphocyte chemotaxis (GO:0048247)2.33643505
123Arp2/3 complex-mediated actin nucleation (GO:0034314)2.33480007
124regulation of mononuclear cell migration (GO:0071675)2.33250594
125protein activation cascade (GO:0072376)2.32987004
126macrophage activation involved in immune response (GO:0002281)2.31948625
127positive regulation of type 2 immune response (GO:0002830)2.31718555
128negative regulation of lipid storage (GO:0010888)2.31692268
129positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.31309017
130cellular response to thyroid hormone stimulus (GO:0097067)2.30724982
131regulation of extracellular matrix disassembly (GO:0010715)2.29800665
132negative regulation of cytokine production involved in immune response (GO:0002719)2.29204631
133positive regulation of chemokine biosynthetic process (GO:0045080)2.29002125
134regulation of dendritic cell antigen processing and presentation (GO:0002604)2.28935030
135positive regulation of T cell mediated cytotoxicity (GO:0001916)2.28816315
136acute-phase response (GO:0006953)2.28777692
137regulation of protein activation cascade (GO:2000257)2.28720445
138regulation of apoptotic process involved in morphogenesis (GO:1902337)2.28510616
139regulation of integrin-mediated signaling pathway (GO:2001044)2.27662595
140regulation of complement activation (GO:0030449)2.27559037
141phagocytosis, engulfment (GO:0006911)2.27200678
142* negative regulation of viral entry into host cell (GO:0046597)2.26798223
143* defense response to virus (GO:0051607)2.26750134
144positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.26700891
145protein heterotrimerization (GO:0070208)2.26514049
146regulation of interleukin-12 biosynthetic process (GO:0045075)2.26500290
147detection of other organism (GO:0098543)2.25940355
148regulation of T-helper 2 cell differentiation (GO:0045628)2.25817016
149adhesion of symbiont to host cell (GO:0044650)2.25579901
150virion attachment to host cell (GO:0019062)2.25579901
151regulation of metalloenzyme activity (GO:0048552)2.25158366
152regulation of cellular extravasation (GO:0002691)2.23213199
153positive regulation of NF-kappaB import into nucleus (GO:0042346)2.21056019
154regulation of chemokine biosynthetic process (GO:0045073)2.20769767

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.74031432
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.87409859
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.22473886
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.07523536
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.89311529
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.65651915
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.49517921
8EGR1_23403033_ChIP-Seq_LIVER_Mouse2.81951989
9* IRF8_27001747_Chip-Seq_BMDM_Mouse2.69148522
10RXR_22158963_ChIP-Seq_LIVER_Mouse2.66684265
11RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.65368708
12PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.57805868
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.55257185
14* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.50623317
15SCL_19346495_ChIP-Seq_HPC-7_Human2.49125234
16* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.44873102
17PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.44102821
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.37815834
19PPARA_22158963_ChIP-Seq_LIVER_Mouse2.35103370
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.33569450
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.24883735
22EGR1_19374776_ChIP-ChIP_THP-1_Human2.24409251
23FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.20732470
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.19665765
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.12610586
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.10427489
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.07339316
28* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.97860600
29RARG_19884340_ChIP-ChIP_MEFs_Mouse1.97811255
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.94101105
31CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.93161912
32Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.89351417
33GATA1_22025678_ChIP-Seq_K562_Human1.88948799
34LXR_22292898_ChIP-Seq_THP-1_Human1.88151789
35LXR_22158963_ChIP-Seq_LIVER_Mouse1.87076467
36STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.84719429
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.77064393
38STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.76690653
39SPI1_23547873_ChIP-Seq_NB4_Human1.74771981
40GATA2_21666600_ChIP-Seq_HMVEC_Human1.67175010
41STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.62178665
42BRD4_27068464_Chip-Seq_AML-cells_Mouse1.61799371
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.60227715
44THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.59598102
45TRIM28_21343339_ChIP-Seq_HEK293_Human1.56085977
46NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.52986936
47* RACK7_27058665_Chip-Seq_MCF-7_Human1.52683166
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.51433045
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.46796425
50* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.44225064
51LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.43469375
52VDR_24763502_ChIP-Seq_THP-1_Human1.41013020
53RUNX1_22412390_ChIP-Seq_EML_Mouse1.37889759
54* ELK3_25401928_ChIP-Seq_HUVEC_Human1.35836357
55* MAF_26560356_Chip-Seq_TH1_Human1.35663942
56TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34979812
57TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34450320
58CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.33382475
59STAT3_1855785_ChIP-Seq_MESCs_Mouse1.32323829
60MYB_26560356_Chip-Seq_TH2_Human1.29388354
61TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.28731833
62FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.28708920
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.26273828
64SMC3_22415368_ChIP-Seq_MEFs_Mouse1.25552076
65NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.25445232
66EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.25196748
67VDR_21846776_ChIP-Seq_THP-1_Human1.24902508
68LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.23775311
69GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.23715548
70CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23588532
71SMC1_22415368_ChIP-Seq_MEFs_Mouse1.23512779
72SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.23192034
73HIF1A_21447827_ChIP-Seq_MCF-7_Human1.22727385
74* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.20936514
75CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20199966
76GATA2_22383799_ChIP-Seq_G1ME_Mouse1.18968383
77KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.18335484
78MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.18054195
79MYB_26560356_Chip-Seq_TH1_Human1.16597647
80BCL6_27268052_Chip-Seq_Bcells_Human1.15631124
81POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.14876364
82ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.14190180
83SRY_22984422_ChIP-ChIP_TESTIS_Rat1.13307050
84JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12529515
85CLOCK_20551151_ChIP-Seq_293T_Human1.11507482
86PU_27001747_Chip-Seq_BMDM_Mouse1.11231712
87SA1_27219007_Chip-Seq_ERYTHROID_Human1.11100883
88SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10048705
89SOX2_20726797_ChIP-Seq_SW620_Human1.09293005
90GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07255416
91SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07124871
92ESR1_21235772_ChIP-Seq_MCF-7_Human1.07108642
93KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05096754
94KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04065576
95CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.03141504
96* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01643381
97SA1_27219007_Chip-Seq_Bcells_Human1.00633526
98STAT6_21828071_ChIP-Seq_BEAS2B_Human0.98507227
99P63_26484246_Chip-Seq_KERATINOCYTES_Human0.98055032
100RUNX_20019798_ChIP-Seq_JUKART_Human0.97975170
101JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97806262
102TET1_21451524_ChIP-Seq_MESCs_Mouse0.97632247
103TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96988611
104* BCOR_27268052_Chip-Seq_Bcells_Human0.96831653
105ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.96630994
106ATF3_27146783_Chip-Seq_COLON_Human0.96476549
107* CTCF_26484167_Chip-Seq_Bcells_Mouse0.96113623
108PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95438543
109* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.95349115
110CSB_26484114_Chip-Seq_FIBROBLAST_Human0.94500514
111CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94430334
112PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93582150
113SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.93522240
114SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.93522240
115ELF1_20517297_ChIP-Seq_JURKAT_Human0.93419369
116SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.93173978
117UTX_26944678_Chip-Seq_JUKART_Human0.92571383
118HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92424521
119CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.92207471
120PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92116566
121SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.92091323
122ELF1_17652178_ChIP-ChIP_JURKAT_Human0.90404091
123PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89812515
124SPI1_23127762_ChIP-Seq_K562_Human0.89382804
125CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89118495
126TCF7_22412390_ChIP-Seq_EML_Mouse0.88252830
127CDX2_20551321_ChIP-Seq_CACO-2_Human0.87887187
128ERG_20887958_ChIP-Seq_HPC-7_Mouse0.87712057
129CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.86554937
130PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86115762
131E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.82493885
132HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.82120426
133FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.81221614
134SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.80640815

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to3.65273978
2MP0001835_abnormal_antigen_presentation3.27577566
3MP0009785_altered_susceptibility_to3.09642707
4MP0003436_decreased_susceptibility_to2.77542818
5MP0004272_abnormal_basement_membrane2.62195905
6MP0000685_abnormal_immune_system2.52711399
7MP0002148_abnormal_hypersensitivity_rea2.51171908
8MP0001542_abnormal_bone_strength2.35915678
9MP0005025_abnormal_response_to2.29830708
10MP0002254_reproductive_system_inflammat2.09103703
11MP0002419_abnormal_innate_immunity2.05838788
12MP0006082_CNS_inflammation2.05070042
13MP0010368_abnormal_lymphatic_system2.03745315
14MP0005000_abnormal_immune_tolerance1.95337078
15MP0005387_immune_system_phenotype1.94339486
16MP0001790_abnormal_immune_system1.94339486
17MP0001853_heart_inflammation1.93599739
18MP0008438_abnormal_cutaneous_collagen1.89935574
19MP0003191_abnormal_cellular_cholesterol1.87840576
20MP0009840_abnormal_foam_cell1.85411027
21MP0002295_abnormal_pulmonary_circulatio1.84244794
22MP0005464_abnormal_platelet_physiology1.82007340
23MP0001533_abnormal_skeleton_physiology1.80478007
24MP0000343_altered_response_to1.77254250
25MP0001545_abnormal_hematopoietic_system1.76511116
26MP0005397_hematopoietic_system_phenotyp1.76511116
27MP0005360_urolithiasis1.73319788
28MP0001800_abnormal_humoral_immune1.73304511
29MP0010155_abnormal_intestine_physiology1.71666694
30MP0009764_decreased_sensitivity_to1.70323682
31MP0002452_abnormal_antigen_presenting1.70209524
32MP0002132_abnormal_respiratory_system1.67941329
33MP0009278_abnormal_bone_marrow1.67490475
34MP0005671_abnormal_response_to1.65732328
35MP0002723_abnormal_immune_serum1.64473912
36MP0002166_altered_tumor_susceptibility1.59972810
37MP0002139_abnormal_hepatobiliary_system1.56399727
38MP0003186_abnormal_redox_activity1.56004547
39MP0008469_abnormal_protein_level1.53868292
40MP0002396_abnormal_hematopoietic_system1.53609843
41MP0005257_abnormal_intraocular_pressure1.52302806
42MP0005085_abnormal_gallbladder_physiolo1.48861845
43MP0001845_abnormal_inflammatory_respons1.47830273
44MP0004947_skin_inflammation1.47226600
45MP0008260_abnormal_autophagy1.47150759
46MP0003300_gastrointestinal_ulcer1.47136596
47MP0003950_abnormal_plasma_membrane1.47079544
48MP0006054_spinal_hemorrhage1.45114439
49MP0003279_aneurysm1.43029145
50MP0001879_abnormal_lymphatic_vessel1.42070385
51MP0005023_abnormal_wound_healing1.41857486
52MP0008875_abnormal_xenobiotic_pharmacok1.41393072
53MP0005365_abnormal_bile_salt1.40755910
54MP0010030_abnormal_orbit_morphology1.40725232
55MP0001819_abnormal_immune_cell1.40039712
56MP0003303_peritoneal_inflammation1.40014237
57MP0002420_abnormal_adaptive_immunity1.39188351
58MP0002405_respiratory_system_inflammati1.37935706
59MP0003705_abnormal_hypodermis_morpholog1.37746041
60MP0004510_myositis1.31291232
61MP0003828_pulmonary_edema1.29901468
62MP0002006_tumorigenesis1.29306569
63MP0009379_abnormal_foot_pigmentation1.28322353
64MP0000465_gastrointestinal_hemorrhage1.26260569
65MP0002138_abnormal_hepatobiliary_system1.26251138
66MP0005508_abnormal_skeleton_morphology1.26096929
67MP0004808_abnormal_hematopoietic_stem1.25399127
68MP0005083_abnormal_biliary_tract1.25373049
69MP0003075_altered_response_to1.23458602
70MP0003448_altered_tumor_morphology1.18386908
71MP0005275_abnormal_skin_tensile1.17110306
72MP0005058_abnormal_lysosome_morphology1.15521735
73MP0003806_abnormal_nucleotide_metabolis1.12918335
74MP0008004_abnormal_stomach_pH1.12765023
75MP0004858_abnormal_nervous_system1.12756708
76MP0009763_increased_sensitivity_to1.12434620
77MP0000716_abnormal_immune_system1.10721576
78MP0005390_skeleton_phenotype1.08864734
79MP0005167_abnormal_blood-brain_barrier1.07265300
80MP0003566_abnormal_cell_adhesion1.06832631
81MP0002398_abnormal_bone_marrow1.06272751
82MP0001851_eye_inflammation1.05375757
83MP0004782_abnormal_surfactant_physiolog1.05342078
84MP0005164_abnormal_response_to1.04785229
85MP0001958_emphysema1.03138735
86MP0000689_abnormal_spleen_morphology1.02853531
87MP0005319_abnormal_enzyme/_coenzyme1.02536196
88MP0003252_abnormal_bile_duct1.01936816
89MP0000858_altered_metastatic_potential1.01797303
90MP0005595_abnormal_vascular_smooth1.00190150
91MP0010329_abnormal_lipoprotein_level0.99808991
92MP0003453_abnormal_keratinocyte_physiol0.99480425
93MP0000767_abnormal_smooth_muscle0.99336341
94MP0005503_abnormal_tendon_morphology0.99228450
95MP0009333_abnormal_splenocyte_physiolog0.98893943
96MP0002429_abnormal_blood_cell0.98810526
97MP0001849_ear_inflammation0.97903056
98MP0000249_abnormal_blood_vessel0.96195183
99MP0002060_abnormal_skin_morphology0.95583357
100MP0000750_abnormal_muscle_regeneration0.94514286
101MP0002722_abnormal_immune_system0.94301582
102MP0001873_stomach_inflammation0.90643870
103MP0003795_abnormal_bone_structure0.89635534
104MP0000609_abnormal_liver_physiology0.88912724
105MP0002108_abnormal_muscle_morphology0.86974635
106MP0002933_joint_inflammation0.86315892
107MP0000490_abnormal_crypts_of0.85616336
108MP0001243_abnormal_dermal_layer0.85440724
109MP0003091_abnormal_cell_migration0.84960431
110MP0004883_abnormal_blood_vessel0.80512547
111MP0002998_abnormal_bone_remodeling0.80178774
112MP0010352_gastrointestinal_tract_polyps0.79865120
113MP0000598_abnormal_liver_morphology0.79383742
114MP0002277_abnormal_respiratory_mucosa0.79191635
115MP0003011_delayed_dark_adaptation0.78635887
116MP0005165_increased_susceptibility_to0.77817746
117MP0005166_decreased_susceptibility_to0.77796323
118MP0002282_abnormal_trachea_morphology0.77526869
119MP0003943_abnormal_hepatobiliary_system0.75986839
120MP0009384_cardiac_valve_regurgitation0.74393686
121MP0000604_amyloidosis0.72660305
122MP0004019_abnormal_vitamin_homeostasis0.71871768
123MP0000751_myopathy0.70395752
124MP0005084_abnormal_gallbladder_morpholo0.68712000
125MP0000749_muscle_degeneration0.64707396

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.17811281
2Systemic lupus erythematosus (HP:0002725)4.64985233
3Elevated erythrocyte sedimentation rate (HP:0003565)4.45064374
4Myositis (HP:0100614)4.06602943
5Recurrent abscess formation (HP:0002722)3.96444076
6Eczematoid dermatitis (HP:0000976)3.92297835
7Recurrent bacterial skin infections (HP:0005406)3.72790823
8Orchitis (HP:0100796)3.48113862
9Recurrent gram-negative bacterial infections (HP:0005420)3.44356639
10Aortic aneurysm (HP:0004942)3.40019893
11Thrombocytosis (HP:0001894)3.26421491
12Aortic dissection (HP:0002647)3.25529575
13Complement deficiency (HP:0004431)3.17387312
14Cervical subluxation (HP:0003308)3.15742376
15Abnormality of the nasal mucosa (HP:0000433)3.14111564
16Vascular tortuosity (HP:0004948)3.09555124
17Chronic otitis media (HP:0000389)3.02278198
18Vertebral compression fractures (HP:0002953)3.01220650
19Autoimmune thrombocytopenia (HP:0001973)3.01100378
20Joint hemorrhage (HP:0005261)2.99530212
21Petechiae (HP:0000967)2.99116101
22Interstitial pulmonary disease (HP:0006530)2.95932976
23Vacuolated lymphocytes (HP:0001922)2.94713433
24Abnormality of complement system (HP:0005339)2.93200985
25Glomerulonephritis (HP:0000099)2.91518670
26Spontaneous hematomas (HP:0007420)2.90251496
27Gingival bleeding (HP:0000225)2.88639448
28Purpura (HP:0000979)2.87559726
29Abnormality of macrophages (HP:0004311)2.81935475
30Blue sclerae (HP:0000592)2.81355968
31Peritonitis (HP:0002586)2.72664322
32Protrusio acetabuli (HP:0003179)2.69656005
33Deep venous thrombosis (HP:0002625)2.68051947
34Epistaxis (HP:0000421)2.66927425
35Follicular hyperkeratosis (HP:0007502)2.65345775
36Pustule (HP:0200039)2.65076243
37Prolonged bleeding time (HP:0003010)2.63595253
38Dilatation of the ascending aorta (HP:0005111)2.59906234
39Atrophic scars (HP:0001075)2.59595012
40Periodontitis (HP:0000704)2.57248897
41Soft skin (HP:0000977)2.57157218
42Abnormality of monocarboxylic acid metabolism (HP:0010996)2.54940377
43Ankle contracture (HP:0006466)2.54875425
44Arterial tortuosity (HP:0005116)2.54867505
45Nasal polyposis (HP:0100582)2.54770228
46Nephritis (HP:0000123)2.53627706
47Prolonged partial thromboplastin time (HP:0003645)2.52996441
48Abnormality of aromatic amino acid family metabolism (HP:0004338)2.49528250
49Hematochezia (HP:0002573)2.49217992
50Recurrent skin infections (HP:0001581)2.48533018
51Increased neuronal autofluorescent lipopigment (HP:0002074)2.44651574
52Esophageal varix (HP:0002040)2.41618256
53Abnormality of the common coagulation pathway (HP:0010990)2.40203544
54Vasculitis (HP:0002633)2.39688233
55Optic neuritis (HP:0100653)2.38847418
56Retrobulbar optic neuritis (HP:0100654)2.38847418
57Mediastinal lymphadenopathy (HP:0100721)2.38543577
58Arterial thrombosis (HP:0004420)2.35863281
59Increased cerebral lipofuscin (HP:0011813)2.35472281
60Thick nail (HP:0001805)2.31535974
61Osteolytic defects of the phalanges of the hand (HP:0009771)2.30206026
62Osteolytic defects of the hand bones (HP:0009699)2.30206026
63Tetraparesis (HP:0002273)2.30153934
64Xanthomatosis (HP:0000991)2.29530581
65Beaking of vertebral bodies (HP:0004568)2.28320721
66Fragile skin (HP:0001030)2.25948939
67Basal ganglia calcification (HP:0002135)2.23924070
68Abnormal platelet function (HP:0011869)2.23753830
69Impaired platelet aggregation (HP:0003540)2.23753830
70Joint stiffness (HP:0001387)2.23149099
71Myocardial infarction (HP:0001658)2.23001915
72Intrahepatic cholestasis (HP:0001406)2.22910455
73Colitis (HP:0002583)2.22185757
74Abnormality of glycolipid metabolism (HP:0010969)2.21232135
75Abnormality of liposaccharide metabolism (HP:0010968)2.21232135
76Abnormality of glycosphingolipid metabolism (HP:0004343)2.21232135
77Spondylolisthesis (HP:0003302)2.19655876
78Menorrhagia (HP:0000132)2.19534521
79Axonal loss (HP:0003447)2.18747939
80Cellulitis (HP:0100658)2.18445032
81Increased connective tissue (HP:0009025)2.18050096
82Abnormality of dentin (HP:0010299)2.17465190
83Increased serum ferritin (HP:0003281)2.15211463
84Broad metatarsal (HP:0001783)2.14949204
85Slender build (HP:0001533)2.12462262
86Hepatosplenomegaly (HP:0001433)2.12246171
87Distal lower limb muscle weakness (HP:0009053)2.10429809
88Recurrent fungal infections (HP:0002841)2.08841357
89Biconcave vertebral bodies (HP:0004586)2.08523117
90Thrombophlebitis (HP:0004418)2.07787767
91Amyloidosis (HP:0011034)2.07409535
92Abnormality of the pericardium (HP:0001697)2.05504982
93Urticaria (HP:0001025)2.05226887
94Reduced antithrombin III activity (HP:0001976)2.04822733
95Abnormality of the intrinsic pathway (HP:0010989)2.04781212
96Reticulocytopenia (HP:0001896)2.04154461
97Bladder diverticulum (HP:0000015)2.03375844
98Cerebral aneurysm (HP:0004944)2.03125937
99Increased variability in muscle fiber diameter (HP:0003557)2.01451966
100Inflammation of the large intestine (HP:0002037)2.01419124
101IgM deficiency (HP:0002850)2.00008350
102Ectopia lentis (HP:0001083)1.97282332
103Spontaneous abortion (HP:0005268)1.95876813
104Gingivitis (HP:0000230)1.94262601
105Loss of speech (HP:0002371)1.94222193
106Pulmonary infiltrates (HP:0002113)1.93446987
107Gastrointestinal inflammation (HP:0004386)1.93366343
108Generalized amyotrophy (HP:0003700)1.93328890
109Pulmonary embolism (HP:0002204)1.93311420
110Abnormality of the vasculature of the conjunctiva (HP:0008054)1.92472367
111Hemorrhage of the eye (HP:0011885)1.92239232
112Abnormality of iron homeostasis (HP:0011031)1.91760154
113Abnormality of the peritoneum (HP:0002585)1.91508653
114Type 1 muscle fiber predominance (HP:0003803)1.91457069
115Keratoconjunctivitis sicca (HP:0001097)1.90117867
116Hyperlipoproteinemia (HP:0010980)1.89964965
117Recurrent viral infections (HP:0004429)1.89824006
118Reduced subcutaneous adipose tissue (HP:0003758)1.89023305
119Segmental peripheral demyelination/remyelination (HP:0003481)1.88716149
120Polycythemia (HP:0001901)1.88669650
121Wormian bones (HP:0002645)1.88208104
122Hypergammaglobulinemia (HP:0010702)1.88037622
123Episodic fever (HP:0001954)1.87397113
124Hypochromic microcytic anemia (HP:0004840)1.86927069
125Increased IgM level (HP:0003496)1.86816172
126Chronic obstructive pulmonary disease (HP:0006510)1.86761790
127Obstructive lung disease (HP:0006536)1.86761790
128Abnormality of cells of the erythroid lineage (HP:0012130)1.86746921
129Increased IgE level (HP:0003212)1.86700932
130Microcytic anemia (HP:0001935)1.86534094
131Recurrent bronchitis (HP:0002837)1.84208123
132Anorexia (HP:0002039)1.83946005
133Gastrointestinal infarctions (HP:0005244)1.83245712
134Emphysema (HP:0002097)1.82877505
135Nonimmune hydrops fetalis (HP:0001790)1.82107708
136Hemoptysis (HP:0002105)1.81679581
137Abnormal gallbladder physiology (HP:0012438)1.81126479
138Cholecystitis (HP:0001082)1.81126479
139Rough bone trabeculation (HP:0100670)1.80767056
140Abnormal delivery (HP:0001787)1.80685194
141Polygenic inheritance (HP:0010982)1.79432440
142Abnormal hemoglobin (HP:0011902)1.78825331
143Aneurysm (HP:0002617)1.78508207
144Abnormality of skeletal muscle fiber size (HP:0012084)1.77728219
145Cardiovascular calcification (HP:0011915)1.77662988
146Poor head control (HP:0002421)1.77412238
147Alopecia of scalp (HP:0002293)1.77385343
148Abnormality of glutamine family amino acid metabolism (HP:0010902)1.77220326
149Abnormality of T cell physiology (HP:0011840)1.76464525
150Hypercholesterolemia (HP:0003124)1.76194500
151Mucopolysacchariduria (HP:0008155)1.75826624
152Urinary glycosaminoglycan excretion (HP:0003541)1.75826624
153Premature loss of primary teeth (HP:0006323)1.75353762
154Spinal rigidity (HP:0003306)1.73166374
155Hypertriglyceridemia (HP:0002155)1.72816831

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.78296987
2TYK23.04424253
3KIT2.96719105
4TBK12.95402295
5VRK22.81092886
6TESK12.64853415
7IKBKE2.59300068
8TGFBR22.58998927
9MAP3K142.54767996
10TIE12.48337420
11NME22.42304238
12TGFBR12.41932626
13PIM22.37007717
14JAK32.27936494
15TESK22.26738829
16BLK2.15250958
17IRAK32.09473345
18KDR2.08253598
19IRAK42.04530912
20IKBKB1.90868370
21FGFR41.90146330
22MAP4K11.87206061
23LIMK11.70949383
24MAP2K31.60313407
25FLT31.57293817
26BTK1.53682197
27EPHB11.51955260
28TEC1.51566892
29ARAF1.51485018
30RPS6KA41.50710733
31GRK61.43049708
32BCKDK1.42147511
33DDR21.40653847
34JAK11.38154724
35EPHA31.37402822
36MAP3K31.35694613
37TNK21.32599876
38PTK21.29798819
39MATK1.29632229
40TAOK21.28464641
41ZAP701.27705625
42LMTK21.22344771
43NEK91.19791086
44CSF1R1.19287429
45PRKD21.17387238
46LRRK21.15854204
47CHUK1.15821217
48PTK2B1.12105601
49MAP3K61.11359258
50PRKG21.07239429
51SMG11.06467988
52MYLK1.05146192
53INSRR1.03150354
54CDC42BPA1.01251235
55ILK1.01108830
56PIM11.00933971
57NLK1.00171443
58TXK0.99883568
59RIPK10.98485843
60FES0.95410731
61GRK70.94598178
62RPS6KB20.93775838
63MAP3K110.93298077
64CSK0.92958133
65ADRBK10.92446545
66PIK3CG0.91122595
67TRPM70.90049684
68FER0.89924019
69TAOK30.89161913
70MAPKAPK30.89156962
71PAK40.86691989
72ABL20.85508477
73GRK50.84929115
74PDGFRA0.83403295
75SYK0.81026698
76LYN0.80798399
77STK160.79539429
78PTK60.78721298
79HCK0.78184429
80MUSK0.77385740
81STK100.76571883
82FGFR30.73814522
83SIK10.73026998
84DAPK30.72271813
85MAPK70.72228108
86PKN20.71294739
87JAK20.71100092
88MST1R0.69975999
89EPHB20.69575116
90PRKD10.68372879
91CDK80.66772580
92PAK10.66737028
93LCK0.65656218
94EIF2AK20.64034832
95SIK30.64024100
96CDK60.63000652
97HIPK20.61577666
98PRPF4B0.61555189
99MAPKAPK50.59218656
100IRAK10.58093565
101CAMKK20.57178043
102STK380.56899049
103BMX0.56679422
104MAP3K120.56346045
105PDK20.55512129
106BMPR1B0.54607375
107MAP2K60.54554877
108NUAK10.54036098
109FGR0.53648960
110MAPK150.53559656
111MST40.52552742
112MOS0.52492095
113TAOK10.50382333
114ROCK20.50240643
115ABL10.49870496
116ERBB30.49660276
117ROCK10.49547828
118MAPK40.49485390
119DAPK10.48855616
120GRK10.47837503
121MAPKAPK20.47221037
122MAPK110.46684193
123PRKCD0.46601007
124PBK0.46553385
125ACVR1B0.44835643
126MET0.44659699
127ZAK0.44085187
128TTN0.44031326
129RIPK40.42686772
130ADRBK20.41758863
131CAMK1D0.41207266
132EPHA20.40962165
133TRIB30.40249444
134RPS6KA50.40248034
135DMPK0.39908335
136PAK20.39178825
137WEE10.38177438
138RPS6KA60.38169598
139MAP3K10.38167809
140MAP2K20.37492563
141CDK70.37297761
142EGFR0.36854162
143GSK3A0.36827345
144DYRK1B0.35259529

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.45606628
2Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.56397016
3Complement and coagulation cascades_Homo sapiens_hsa046102.45376017
4Leishmaniasis_Homo sapiens_hsa051402.42601455
5Malaria_Homo sapiens_hsa051442.20993511
6Caffeine metabolism_Homo sapiens_hsa002322.19825901
7RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.19307182
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.16263362
9Toll-like receptor signaling pathway_Homo sapiens_hsa046202.09292084
10Ribosome_Homo sapiens_hsa030102.04149713
11Pentose and glucuronate interconversions_Homo sapiens_hsa000401.97395280
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.91105668
13Pertussis_Homo sapiens_hsa051331.88567384
14Legionellosis_Homo sapiens_hsa051341.83943973
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.80084587
16Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.76714852
17Measles_Homo sapiens_hsa051621.70149998
18Autoimmune thyroid disease_Homo sapiens_hsa053201.69702450
19Asthma_Homo sapiens_hsa053101.65204642
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.61268735
21Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.58825975
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.56106710
23Influenza A_Homo sapiens_hsa051641.53424955
24Herpes simplex infection_Homo sapiens_hsa051681.51786653
25TNF signaling pathway_Homo sapiens_hsa046681.45799924
26Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.43994437
27Antigen processing and presentation_Homo sapiens_hsa046121.43110485
28Osteoclast differentiation_Homo sapiens_hsa043801.40443721
29Chemical carcinogenesis_Homo sapiens_hsa052041.38380285
30African trypanosomiasis_Homo sapiens_hsa051431.36602399
31NOD-like receptor signaling pathway_Homo sapiens_hsa046211.36247490
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.33413512
33Glycosaminoglycan degradation_Homo sapiens_hsa005311.32686154
34Toxoplasmosis_Homo sapiens_hsa051451.30954987
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.29701946
36Allograft rejection_Homo sapiens_hsa053301.28333635
37SNARE interactions in vesicular transport_Homo sapiens_hsa041301.26804156
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.19864659
39Oxidative phosphorylation_Homo sapiens_hsa001901.18532525
40Folate biosynthesis_Homo sapiens_hsa007901.18396044
41Drug metabolism - other enzymes_Homo sapiens_hsa009831.16315417
42Hematopoietic cell lineage_Homo sapiens_hsa046401.16284106
43Other glycan degradation_Homo sapiens_hsa005111.16168987
44Tuberculosis_Homo sapiens_hsa051521.05253933
45Histidine metabolism_Homo sapiens_hsa003401.02951598
46Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00986935
47Apoptosis_Homo sapiens_hsa042101.00775736
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.99848510
49Parkinsons disease_Homo sapiens_hsa050120.99086248
50Shigellosis_Homo sapiens_hsa051310.97431430
51Arginine biosynthesis_Homo sapiens_hsa002200.97292040
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.95311692
53Graft-versus-host disease_Homo sapiens_hsa053320.95246304
54Retinol metabolism_Homo sapiens_hsa008300.95043449
55Hepatitis C_Homo sapiens_hsa051600.94623398
56Sulfur metabolism_Homo sapiens_hsa009200.94602479
57Salmonella infection_Homo sapiens_hsa051320.93126937
58Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.92665370
59Rheumatoid arthritis_Homo sapiens_hsa053230.91837789
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.91804099
61Tryptophan metabolism_Homo sapiens_hsa003800.88574309
62B cell receptor signaling pathway_Homo sapiens_hsa046620.87871249
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.87483694
64Peroxisome_Homo sapiens_hsa041460.86398493
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84471232
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.84379894
67Lysosome_Homo sapiens_hsa041420.83761774
68Type I diabetes mellitus_Homo sapiens_hsa049400.81743372
69Protein digestion and absorption_Homo sapiens_hsa049740.81145357
70Focal adhesion_Homo sapiens_hsa045100.81130298
71Amoebiasis_Homo sapiens_hsa051460.80361655
72Hepatitis B_Homo sapiens_hsa051610.79740335
73Sulfur relay system_Homo sapiens_hsa041220.78229304
74Fatty acid degradation_Homo sapiens_hsa000710.77346875
75Leukocyte transendothelial migration_Homo sapiens_hsa046700.76950796
76Fructose and mannose metabolism_Homo sapiens_hsa000510.75756688
77Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.75598722
78Starch and sucrose metabolism_Homo sapiens_hsa005000.71294251
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71134046
80Phenylalanine metabolism_Homo sapiens_hsa003600.70865971
81Glutathione metabolism_Homo sapiens_hsa004800.69628108
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69134775
83Proteasome_Homo sapiens_hsa030500.68257289
84Tyrosine metabolism_Homo sapiens_hsa003500.67570862
85Endocytosis_Homo sapiens_hsa041440.67029210
86PPAR signaling pathway_Homo sapiens_hsa033200.66237544
87Alzheimers disease_Homo sapiens_hsa050100.66218405
88Platelet activation_Homo sapiens_hsa046110.66128573
89Arachidonic acid metabolism_Homo sapiens_hsa005900.65942183
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63940120
91Primary immunodeficiency_Homo sapiens_hsa053400.63096501
92Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62017081
93Vibrio cholerae infection_Homo sapiens_hsa051100.58316201
94Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58203041
95Acute myeloid leukemia_Homo sapiens_hsa052210.58125474
96Mineral absorption_Homo sapiens_hsa049780.57881312
97Galactose metabolism_Homo sapiens_hsa000520.57461664
98ABC transporters_Homo sapiens_hsa020100.56602452
99Vitamin digestion and absorption_Homo sapiens_hsa049770.56258265
100Phagosome_Homo sapiens_hsa041450.55654583
101Small cell lung cancer_Homo sapiens_hsa052220.54994547
102DNA replication_Homo sapiens_hsa030300.54350771
103Proteoglycans in cancer_Homo sapiens_hsa052050.54216217
104ECM-receptor interaction_Homo sapiens_hsa045120.53107869
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52422031
106Cyanoamino acid metabolism_Homo sapiens_hsa004600.52406761
107beta-Alanine metabolism_Homo sapiens_hsa004100.52290153
108Chemokine signaling pathway_Homo sapiens_hsa040620.52105729
109Prion diseases_Homo sapiens_hsa050200.51401078
110Pentose phosphate pathway_Homo sapiens_hsa000300.50288525
111Nitrogen metabolism_Homo sapiens_hsa009100.49639031
112Viral myocarditis_Homo sapiens_hsa054160.47021480
113Fatty acid elongation_Homo sapiens_hsa000620.46541271
114p53 signaling pathway_Homo sapiens_hsa041150.46165058
115Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46150275
116Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45881255
117Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.45742302
118Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42993244
119Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42950291
120Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.42331621
121Huntingtons disease_Homo sapiens_hsa050160.40346157
122One carbon pool by folate_Homo sapiens_hsa006700.40142663
123Notch signaling pathway_Homo sapiens_hsa043300.40129598
124Pyrimidine metabolism_Homo sapiens_hsa002400.38202318
125Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37939620

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