IFITM4P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)9.93843131
2regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)8.39540219
3regulation of regulatory T cell differentiation (GO:0045589)6.62146209
4regulation of isotype switching to IgG isotypes (GO:0048302)6.45681409
5regulation of immunoglobulin secretion (GO:0051023)6.29104264
6positive regulation of interleukin-17 production (GO:0032740)6.10013241
7regulation of chronic inflammatory response (GO:0002676)5.85458241
8GTP biosynthetic process (GO:0006183)5.21288747
9negative regulation of B cell apoptotic process (GO:0002903)4.91768365
10positive regulation of isotype switching (GO:0045830)4.88769475
11mRNA cleavage (GO:0006379)4.78207395
12UTP biosynthetic process (GO:0006228)4.77845722
13nucleoside diphosphate phosphorylation (GO:0006165)4.63243459
14positive regulation of immunoglobulin mediated immune response (GO:0002891)4.53147277
15positive regulation of B cell mediated immunity (GO:0002714)4.53147277
16positive regulation of DNA recombination (GO:0045911)4.47885002
17regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.36409582
18positive regulation of activated T cell proliferation (GO:0042104)4.24785370
19negative regulation of defense response to virus (GO:0050687)4.19776508
20UTP metabolic process (GO:0046051)4.14866666
21AMP metabolic process (GO:0046033)4.06997619
22positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)3.98675006
23regulation of phospholipase A2 activity (GO:0032429)3.95411832
24cellular response to zinc ion (GO:0071294)3.87874928
25response to interferon-alpha (GO:0035455)3.80325839
26positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.73634139
27regulation of interleukin-17 production (GO:0032660)3.67474301
28embryonic hemopoiesis (GO:0035162)3.66135636
29negative regulation of viral entry into host cell (GO:0046597)3.62195779
30positive regulation of humoral immune response (GO:0002922)3.62060922
31CTP biosynthetic process (GO:0006241)3.59182378
32CTP metabolic process (GO:0046036)3.59182378
33guanosine-containing compound biosynthetic process (GO:1901070)3.51261087
34glyoxylate metabolic process (GO:0046487)3.48852636
35regulation of B cell apoptotic process (GO:0002902)3.47820186
36negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.44342175
37regulation of tyrosine phosphorylation of STAT protein (GO:0042509)3.43426335
38L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.42820305
39pyrimidine ribonucleoside biosynthetic process (GO:0046132)3.39671872
40rRNA methylation (GO:0031167)3.38382663
41pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.36812770
42regulation of autophagic vacuole assembly (GO:2000785)3.32229509
43positive regulation of cellular amide metabolic process (GO:0034250)3.30899115
44cellular response to cadmium ion (GO:0071276)3.30596300
45regulation of immunoglobulin mediated immune response (GO:0002889)3.30358015
46positive regulation of JAK-STAT cascade (GO:0046427)3.30169409
47cofactor catabolic process (GO:0051187)3.29019390
48regulation of B cell mediated immunity (GO:0002712)3.24158089
49regulation of activated T cell proliferation (GO:0046006)3.20609229
50regulation of isotype switching (GO:0045191)3.19089087
51coenzyme catabolic process (GO:0009109)3.18806360
52positive regulation of immunoglobulin production (GO:0002639)3.17876997
53pyrimidine ribonucleotide biosynthetic process (GO:0009220)3.17495868
54response to interferon-beta (GO:0035456)3.15847871
55positive regulation of tissue remodeling (GO:0034105)3.14634172
56regulation of vacuole organization (GO:0044088)3.10932371
57negative regulation of smooth muscle cell proliferation (GO:0048662)3.06338697
58positive regulation of T cell migration (GO:2000406)3.03682856
59negative regulation of response to biotic stimulus (GO:0002832)2.98832177
60pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.97829936
61DNA double-strand break processing (GO:0000729)2.97496752
62nucleoside diphosphate biosynthetic process (GO:0009133)2.96662667
63lymph node development (GO:0048535)2.91867062
64rRNA modification (GO:0000154)2.91366849
65ADP metabolic process (GO:0046031)2.90902041
66negative regulation of growth of symbiont in host (GO:0044130)2.90237870
67negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.90237870
68modulation of growth of symbiont involved in interaction with host (GO:0044144)2.90237870
69regulation of growth of symbiont in host (GO:0044126)2.90237870
70amino acid salvage (GO:0043102)2.85842568
71L-methionine salvage (GO:0071267)2.85842568
72L-methionine biosynthetic process (GO:0071265)2.85842568
73pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.84898507
74negative regulation of viral genome replication (GO:0045071)2.83388491
75maturation of 5.8S rRNA (GO:0000460)2.83010684
76ribosome assembly (GO:0042255)2.81621508
77activation of protein kinase B activity (GO:0032148)2.80279292
78positive regulation of protein kinase C signaling (GO:0090037)2.79929796
79regulation of podosome assembly (GO:0071801)2.78552967
80positive regulation of T cell mediated cytotoxicity (GO:0001916)2.77128928
81diterpenoid biosynthetic process (GO:0016102)2.74628311
82CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.73881032
83nucleotide phosphorylation (GO:0046939)2.73216810
84TOR signaling (GO:0031929)2.72450100
85negative regulation of lymphocyte apoptotic process (GO:0070229)2.69797201
86proteasome assembly (GO:0043248)2.69715652
87terpenoid biosynthetic process (GO:0016114)2.68177691
88positive regulation of interferon-gamma production (GO:0032729)2.67988966
89regulation of inflammatory response to antigenic stimulus (GO:0002861)2.67876291
90pyrimidine ribonucleotide metabolic process (GO:0009218)2.64725302
91response to mercury ion (GO:0046689)2.64271629
92hormone catabolic process (GO:0042447)2.64270216
93DNA deamination (GO:0045006)2.63853540
94SMAD protein complex assembly (GO:0007183)2.63836173
95regulation of JAK-STAT cascade (GO:0046425)2.63614641
96positive regulation of B cell proliferation (GO:0030890)2.59946359
97cytokine production involved in immune response (GO:0002367)2.59701800
98regulation of T cell migration (GO:2000404)2.59461553
99regulation of viral entry into host cell (GO:0046596)2.59017543
100pyrimidine nucleoside biosynthetic process (GO:0046134)2.58054097

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human8.23364099
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.90710035
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.45011552
4GATA1_22025678_ChIP-Seq_K562_Human3.29924107
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.82020686
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.63637167
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.44599509
8STAT4_19710469_ChIP-ChIP_TH1__Mouse2.29290544
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.28297307
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.26638446
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.19237545
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.01555656
13CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.97070767
14NOTCH1_21737748_ChIP-Seq_TLL_Human1.95741019
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.95189359
16MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.91102766
17EGR1_23403033_ChIP-Seq_LIVER_Mouse1.89166446
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.78490097
19RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.74081193
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.71354992
21SRF_21415370_ChIP-Seq_HL-1_Mouse1.62548907
22IRF8_21731497_ChIP-ChIP_J774_Mouse1.59120610
23DCP1A_22483619_ChIP-Seq_HELA_Human1.56660120
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.55635091
25ESR1_20079471_ChIP-ChIP_T-47D_Human1.53529251
26ELF1_20517297_ChIP-Seq_JURKAT_Human1.52451443
27ETS1_20019798_ChIP-Seq_JURKAT_Human1.51686143
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.49313269
29PPARA_22158963_ChIP-Seq_LIVER_Mouse1.48699292
30MAF_26560356_Chip-Seq_TH2_Human1.48600958
31TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47214906
32ZNF263_19887448_ChIP-Seq_K562_Human1.46767206
33GATA3_26560356_Chip-Seq_TH2_Human1.41197999
34ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.39363897
35RXR_22158963_ChIP-Seq_LIVER_Mouse1.39316296
36MYB_26560356_Chip-Seq_TH1_Human1.36611745
37SRY_22984422_ChIP-ChIP_TESTIS_Rat1.34174613
38HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.30556367
39SPI1_23547873_ChIP-Seq_NB4_Human1.29451865
40EST1_17652178_ChIP-ChIP_JURKAT_Human1.29285206
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.27737940
42VDR_23849224_ChIP-Seq_CD4+_Human1.27687764
43NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.26196826
44SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.24801844
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.19727336
46GATA3_27048872_Chip-Seq_THYMUS_Human1.19467836
47* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.18934534
48SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.17567242
49CTCF_20526341_ChIP-Seq_ESCs_Human1.17011346
50TBX5_21415370_ChIP-Seq_HL-1_Mouse1.15873482
51FOXP3_21729870_ChIP-Seq_TREG_Human1.15416393
52FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.14355116
53CTCF_21964334_ChIP-Seq_BJAB-B_Human1.13198035
54ERA_21632823_ChIP-Seq_H3396_Human1.13123816
55VDR_22108803_ChIP-Seq_LS180_Human1.12723644
56SPI1_23127762_ChIP-Seq_K562_Human1.12702602
57BCL6_27268052_Chip-Seq_Bcells_Human1.11106723
58* ELK3_25401928_ChIP-Seq_HUVEC_Human1.10333764
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.10217004
60VDR_21846776_ChIP-Seq_THP-1_Human1.09858445
61* CTCF_21964334_Chip-Seq_Bcells_Human1.09732985
62GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.08092056
63MAF_26560356_Chip-Seq_TH1_Human1.06802500
64NANOG_20526341_ChIP-Seq_ESCs_Human1.06107561
65MYB_26560356_Chip-Seq_TH2_Human1.05592468
66SPI1_20517297_ChIP-Seq_HL60_Human1.03984354
67SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03643791
68ER_23166858_ChIP-Seq_MCF-7_Human1.03336717
69IKZF1_21737484_ChIP-ChIP_HCT116_Human1.03257551
70STAT1_20625510_ChIP-Seq_HELA_Human1.01673745
71TFEB_21752829_ChIP-Seq_HELA_Human0.99601599
72PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.99590201
73GATA6_21074721_ChIP-Seq_CACO-2_Human0.98940930
74CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98030728
75DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97662088
76TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.97523062
77UTX_26944678_Chip-Seq_JUKART_Human0.96445819
78E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.96228856
79ELF5_23300383_ChIP-Seq_T47D_Human0.96052706
80CSB_26484114_Chip-Seq_FIBROBLAST_Human0.95830472
81SA1_27219007_Chip-Seq_Bcells_Human0.95456106
82CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.95278882
83HNFA_21074721_ChIP-Seq_CACO-2_Human0.94051887
84RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.92277786
85BCOR_27268052_Chip-Seq_Bcells_Human0.92264066
86PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92011574
87VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.90548432
88* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.89774260
89TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87809345
90PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.86972424
91TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86960261
92CBP_21632823_ChIP-Seq_H3396_Human0.86837150
93PHF8_20622853_ChIP-Seq_HELA_Human0.86464532
94* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86285477
95YY1_21170310_ChIP-Seq_MESCs_Mouse0.85957244
96E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.85880888
97ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85254761
98CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.84456060
99SA1_27219007_Chip-Seq_ERYTHROID_Human0.83388150
100GATA1_19941826_ChIP-Seq_K562_Human0.82272859

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002138_abnormal_hepatobiliary_system6.98570733
2MP0003806_abnormal_nucleotide_metabolis4.79528553
3MP0001835_abnormal_antigen_presentation4.25135547
4MP0009697_abnormal_copulation3.54678005
5MP0003300_gastrointestinal_ulcer3.39439409
6MP0000685_abnormal_immune_system3.06083972
7MP0001853_heart_inflammation2.92183384
8MP0002139_abnormal_hepatobiliary_system2.69165365
9MP0003656_abnormal_erythrocyte_physiolo2.48972806
10MP0009785_altered_susceptibility_to2.46894282
11MP0000465_gastrointestinal_hemorrhage2.34567010
12MP0002148_abnormal_hypersensitivity_rea2.22807127
13MP0002132_abnormal_respiratory_system2.19832465
14MP0003436_decreased_susceptibility_to2.09353573
15MP0004272_abnormal_basement_membrane1.99353837
16MP0000604_amyloidosis1.97084998
17MP0000749_muscle_degeneration1.83678136
18MP0005360_urolithiasis1.83189932
19MP0008004_abnormal_stomach_pH1.79869656
20MP0001849_ear_inflammation1.71724713
21MP0005387_immune_system_phenotype1.68649695
22MP0001790_abnormal_immune_system1.68649695
23MP0005083_abnormal_biliary_tract1.66537021
24MP0004147_increased_porphyrin_level1.65376358
25MP0009840_abnormal_foam_cell1.62185270
26MP0003868_abnormal_feces_composition1.55738375
27MP0005025_abnormal_response_to1.50011007
28MP0002876_abnormal_thyroid_physiology1.44046272
29MP0001800_abnormal_humoral_immune1.40937934
30MP0004084_abnormal_cardiac_muscle1.34710903
31MP0001845_abnormal_inflammatory_respons1.28976310
32MP0005671_abnormal_response_to1.28432386
33MP0005000_abnormal_immune_tolerance1.27583483
34MP0003195_calcinosis1.27257748
35MP0002405_respiratory_system_inflammati1.27197980
36MP0002837_dystrophic_cardiac_calcinosis1.24348536
37MP0008775_abnormal_heart_ventricle1.18243512
38MP0003878_abnormal_ear_physiology1.17501879
39MP0005377_hearing/vestibular/ear_phenot1.17501879
40MP0001764_abnormal_homeostasis1.17053027
41MP0009764_decreased_sensitivity_to1.16832308
42MP0003186_abnormal_redox_activity1.14108717
43MP0000747_muscle_weakness1.10413017
44MP0010155_abnormal_intestine_physiology1.09683249
45MP0002419_abnormal_innate_immunity1.08882050
46MP0002723_abnormal_immune_serum1.06602077
47MP0006036_abnormal_mitochondrial_physio1.06554966
48MP0002420_abnormal_adaptive_immunity1.06454561
49MP0009333_abnormal_splenocyte_physiolog1.06195178
50MP0001661_extended_life_span1.05470401
51MP0004036_abnormal_muscle_relaxation1.03953633
52MP0001819_abnormal_immune_cell1.03426358
53MP0000490_abnormal_crypts_of1.02781929
54MP0005451_abnormal_body_composition1.02009003
55MP0000343_altered_response_to1.01155959
56MP0001873_stomach_inflammation1.00281969
57MP0002452_abnormal_antigen_presenting1.00107668
58MP0002166_altered_tumor_susceptibility0.98762290
59MP0002398_abnormal_bone_marrow0.98173588
60MP0001501_abnormal_sleep_pattern0.97806213
61MP0008469_abnormal_protein_level0.97048482
62MP0005166_decreased_susceptibility_to0.96796145
63MP0008438_abnormal_cutaneous_collagen0.94978730
64MP0004145_abnormal_muscle_electrophysio0.94412610
65MP0005330_cardiomyopathy0.93310369
66MP0005503_abnormal_tendon_morphology0.91239347
67MP0001958_emphysema0.91135395
68MP0003724_increased_susceptibility_to0.91036390
69MP0004510_myositis0.90199209
70MP0005165_increased_susceptibility_to0.89474567
71MP0001348_abnormal_lacrimal_gland0.89198141
72MP0010368_abnormal_lymphatic_system0.85878335
73MP0001533_abnormal_skeleton_physiology0.83112592
74MP0005058_abnormal_lysosome_morphology0.82841005
75MP0006082_CNS_inflammation0.82605045
76MP0008875_abnormal_xenobiotic_pharmacok0.81613222
77MP0002722_abnormal_immune_system0.81577443
78MP0005085_abnormal_gallbladder_physiolo0.80556247
79MP0005332_abnormal_amino_acid0.80534397
80MP0002332_abnormal_exercise_endurance0.80387873
81MP0005319_abnormal_enzyme/_coenzyme0.80207943
82MP0004381_abnormal_hair_follicle0.78833490
83MP0003763_abnormal_thymus_physiology0.78396548
84MP0000689_abnormal_spleen_morphology0.77675661
85MP0010386_abnormal_urinary_bladder0.75535491
86MP0002998_abnormal_bone_remodeling0.73673653
87MP0002429_abnormal_blood_cell0.72828679
88MP0000249_abnormal_blood_vessel0.72639180
89MP0000716_abnormal_immune_system0.72626282
90MP0002269_muscular_atrophy0.69080771
91MP0004264_abnormal_extraembryonic_tissu0.68270659
92MP0003172_abnormal_lysosome_physiology0.66098969
93MP0002295_abnormal_pulmonary_circulatio0.65793230
94MP0000609_abnormal_liver_physiology0.64835312
95MP0002006_tumorigenesis0.64244843
96MP0002108_abnormal_muscle_morphology0.61346390
97MP0003879_abnormal_hair_cell0.60723509
98MP0004782_abnormal_surfactant_physiolog0.59717283
99MP0002254_reproductive_system_inflammat0.59591133
100MP0005376_homeostasis/metabolism_phenot0.59321540

Predicted human phenotypes

RankGene SetZ-score
1Reduced antithrombin III activity (HP:0001976)4.45039812
2Cholecystitis (HP:0001082)4.22618502
3Abnormal gallbladder physiology (HP:0012438)4.22618502
4Retinal dysplasia (HP:0007973)4.13101610
5Stomatitis (HP:0010280)4.01750330
6Diaphragmatic weakness (HP:0009113)3.89647007
7Ulnar claw (HP:0001178)3.74949143
8Abnormality of pyrimidine metabolism (HP:0004353)3.59115051
9Segmental peripheral demyelination/remyelination (HP:0003481)3.47093302
10Abnormality of the heme biosynthetic pathway (HP:0010472)3.33557329
11Gastrointestinal infarctions (HP:0005244)3.22381423
12Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)3.14687959
13Abnormality of the columella (HP:0009929)3.08570132
14Deep venous thrombosis (HP:0002625)3.03676955
15Eosinophilia (HP:0001880)3.02542464
16Abnormal pupillary function (HP:0007686)2.97101675
17Glomerulonephritis (HP:0000099)2.83516067
18Delayed CNS myelination (HP:0002188)2.76022486
19Acute necrotizing encephalopathy (HP:0006965)2.74454870
20Tongue fasciculations (HP:0001308)2.74164980
21Abnormality of monocarboxylic acid metabolism (HP:0010996)2.70655735
22Granulocytopenia (HP:0001913)2.69184604
23Sensory axonal neuropathy (HP:0003390)2.67841028
24Microcytic anemia (HP:0001935)2.65970324
25Acute encephalopathy (HP:0006846)2.63560246
26Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.62840769
27Cholelithiasis (HP:0001081)2.61653593
28Hypertensive crisis (HP:0100735)2.55926898
29Muscle fibrillation (HP:0010546)2.55806501
30Clumsiness (HP:0002312)2.49620721
31Hyporeflexia of lower limbs (HP:0002600)2.48460230
32Abnormality of the shoulder girdle musculature (HP:0001435)2.47924431
33Abnormal tarsal ossification (HP:0008369)2.46731441
34Abnormality of the frontal sinuses (HP:0002687)2.45619912
35Progressive macrocephaly (HP:0004481)2.43823941
36Increased IgM level (HP:0003496)2.43093351
37Poikilocytosis (HP:0004447)2.41562771
38Abnormality of the vocal cords (HP:0008777)2.40155905
39Absent rod-and cone-mediated responses on ERG (HP:0007688)2.38807497
40Abnormal mitochondria in muscle tissue (HP:0008316)2.37075129
41Aortic aneurysm (HP:0004942)2.36346546
42Aplasia/Hypoplasia involving the musculature (HP:0001460)2.36345446
43Ileus (HP:0002595)2.35783152
44Paralysis (HP:0003470)2.35462029
45Foot dorsiflexor weakness (HP:0009027)2.29476857
46Hepatocellular necrosis (HP:0001404)2.25236740
47Systemic lupus erythematosus (HP:0002725)2.23850651
48Inflammation of the large intestine (HP:0002037)2.22934846
49Abnormal gallbladder morphology (HP:0012437)2.21679595
50Recurrent cutaneous fungal infections (HP:0011370)2.16410105
51Chronic mucocutaneous candidiasis (HP:0002728)2.16410105
52Squamous cell carcinoma (HP:0002860)2.13344188
53Difficulty walking (HP:0002355)2.12587805
54Elevated erythrocyte sedimentation rate (HP:0003565)2.11311539
55Ventricular fibrillation (HP:0001663)2.07033990
56Abnormality of aromatic amino acid family metabolism (HP:0004338)2.06914266
57Chronic sinusitis (HP:0011109)2.06869783
58Centrally nucleated skeletal muscle fibers (HP:0003687)2.06232143
59Pustule (HP:0200039)2.05316133
60Anorexia (HP:0002039)2.05126305
61IgA deficiency (HP:0002720)2.04577818
62Gastrointestinal inflammation (HP:0004386)2.02297490
63Increased CSF protein (HP:0002922)2.00524270
64Abnormality of the foot musculature (HP:0001436)2.00028468
65Spinal muscular atrophy (HP:0007269)1.96164611
66Duplicated collecting system (HP:0000081)1.95550678
67Aplastic anemia (HP:0001915)1.95279113
68Mitochondrial inheritance (HP:0001427)1.95136524
69Abnormality of the incisor (HP:0000676)1.95013276
70Rough bone trabeculation (HP:0100670)1.94366542
71Median cleft lip (HP:0000161)1.93996868
72Stridor (HP:0010307)1.91070111
73IgG deficiency (HP:0004315)1.90778378
74Abnormality of the anterior horn cell (HP:0006802)1.89397294
75Degeneration of anterior horn cells (HP:0002398)1.89397294
76Prolonged partial thromboplastin time (HP:0003645)1.88746323
77Reticulocytosis (HP:0001923)1.87937136
78Muscle fiber splitting (HP:0003555)1.86844810
79Type II lissencephaly (HP:0007260)1.86005032
80Scapular winging (HP:0003691)1.83135009
81Metaphyseal dysplasia (HP:0100255)1.82548100
82Cerebral hypomyelination (HP:0006808)1.81915897
83Increased CSF lactate (HP:0002490)1.81002619
84Hypochromic microcytic anemia (HP:0004840)1.80662208
85Complement deficiency (HP:0004431)1.79993602
86Gangrene (HP:0100758)1.78912440
87Decreased activity of mitochondrial respiratory chain (HP:0008972)1.78551077
88Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.78551077
89Abnormal delayed hypersensitivity skin test (HP:0002963)1.77434288
90Hypothermia (HP:0002045)1.77050659
91Abnormality of the intrinsic pathway (HP:0010989)1.76057693
92Abnormality of eosinophils (HP:0001879)1.75461301
93Recurrent fungal infections (HP:0002841)1.74964638
94Recurrent viral infections (HP:0004429)1.74676405
95Increased serum ferritin (HP:0003281)1.74575818
96Abnormality of the renal collecting system (HP:0004742)1.74269498
97Joint hemorrhage (HP:0005261)1.73554866
98Premature ovarian failure (HP:0008209)1.73527162
99Polycythemia (HP:0001901)1.73422242
100Nausea (HP:0002018)1.73181579

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR1B5.33955379
2NME24.06408594
3PINK13.97842895
4CDK83.86218731
5TGFBR13.73125965
6MYLK3.54260600
7MARK33.30798181
8MAPKAPK33.01976146
9BLK2.85582731
10NEK22.65648056
11EIF2AK12.35946204
12EIF2AK32.24603100
13LATS12.14124047
14OBSCN1.78360232
15STK38L1.73016689
16MAP3K131.64958819
17MOS1.48981516
18RIPK41.48852646
19TLK11.47681807
20ILK1.46159620
21SIK31.44126034
22NME11.43866027
23STK381.41118252
24TEC1.34648179
25VRK11.33689127
26PAK41.27814067
27SIK21.26515381
28ARAF1.26260406
29CDK91.23322064
30DAPK31.07306852
31LATS21.06498897
32MAP4K11.06049777
33GRK61.01655281
34RPS6KA40.98647971
35DAPK10.98234727
36PRKG20.97002670
37PAK10.96294021
38BUB10.93814426
39TRIM280.93334631
40SRPK10.92987020
41MAP3K90.92696546
42ZAK0.88573542
43MAPKAPK20.86745733
44PIK3CG0.85391161
45VRK20.84670445
46PRKCQ0.81365764
47CDK30.80247225
48MAP3K10.79855958
49CSNK1A1L0.77956384
50MELK0.75799864
51MAPK120.75757442
52ZAP700.75323754
53PLK30.72795166
54GRK10.72133038
55MAP3K50.71843017
56PAK20.71608537
57CLK10.65948861
58MST40.64702723
59MAP2K70.63478595
60BTK0.63146802
61MAP3K30.62227515
62FRK0.61093759
63CSNK1G30.56512194
64EGFR0.55127908
65PKN10.52355957
66PTK2B0.51542492
67PHKG10.50890086
68PHKG20.50890086
69SIK10.50776429
70BMPR20.49124020
71ICK0.49073808
72ADRBK20.48002795
73CDC42BPA0.47818886
74CSK0.47395433
75GRK50.47175045
76TAOK20.47144230
77RPS6KA50.44812222
78PBK0.44437258
79KIT0.42057694
80CDK70.41587840
81TIE10.41449821
82JAK10.37551598
83PRPF4B0.36733070
84STK30.35957011
85IKBKB0.35859138
86EIF2AK20.34387997
87SMG10.33327162
88RPS6KB10.33295049
89TGFBR20.31790776
90DYRK30.31748514
91MUSK0.30329756
92PLK10.29828770
93TRPM70.27814010
94SYK0.27077894
95LYN0.23961507
96TNK20.23767587
97MAP3K140.23049050
98SGK2230.22769516
99SGK4940.22769516
100PDPK10.20368899

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.36546731
2Allograft rejection_Homo sapiens_hsa053303.51905309
3Autoimmune thyroid disease_Homo sapiens_hsa053203.21232008
4Graft-versus-host disease_Homo sapiens_hsa053322.91892305
5Type I diabetes mellitus_Homo sapiens_hsa049402.90345384
6Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.87142283
7Hematopoietic cell lineage_Homo sapiens_hsa046402.72321314
8Proteasome_Homo sapiens_hsa030502.61497884
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.58849890
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.34898877
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.25731159
12Jak-STAT signaling pathway_Homo sapiens_hsa046302.01134761
13Pentose and glucuronate interconversions_Homo sapiens_hsa000401.95306089
14Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.85047681
15Basal transcription factors_Homo sapiens_hsa030221.82774832
16Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.76623281
17Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.71760861
18SNARE interactions in vesicular transport_Homo sapiens_hsa041301.71166064
19Complement and coagulation cascades_Homo sapiens_hsa046101.70300882
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.52272425
21Chemical carcinogenesis_Homo sapiens_hsa052041.50406569
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.43613812
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.41984979
24Staphylococcus aureus infection_Homo sapiens_hsa051501.36327919
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.30364414
26Dorso-ventral axis formation_Homo sapiens_hsa043201.26293974
27Malaria_Homo sapiens_hsa051441.25402010
28Olfactory transduction_Homo sapiens_hsa047401.25112660
29Peroxisome_Homo sapiens_hsa041461.24237705
30Nitrogen metabolism_Homo sapiens_hsa009101.22140453
31Primary immunodeficiency_Homo sapiens_hsa053401.19421550
32Pentose phosphate pathway_Homo sapiens_hsa000301.15873174
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.15800108
34Pyrimidine metabolism_Homo sapiens_hsa002401.15472562
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.11346816
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.08769826
37Apoptosis_Homo sapiens_hsa042101.05317643
38Rheumatoid arthritis_Homo sapiens_hsa053231.05230713
39Arginine biosynthesis_Homo sapiens_hsa002201.02441800
40Phenylalanine metabolism_Homo sapiens_hsa003601.02168114
41Retinol metabolism_Homo sapiens_hsa008300.98108152
42Measles_Homo sapiens_hsa051620.97026501
43Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.96665184
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.95168299
45Butanoate metabolism_Homo sapiens_hsa006500.92138307
46RNA degradation_Homo sapiens_hsa030180.90152942
47Cysteine and methionine metabolism_Homo sapiens_hsa002700.90013470
48Regulation of autophagy_Homo sapiens_hsa041400.88559191
49Mineral absorption_Homo sapiens_hsa049780.86873500
50Herpes simplex infection_Homo sapiens_hsa051680.82391022
51RNA polymerase_Homo sapiens_hsa030200.82237106
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.81707496
53Antigen processing and presentation_Homo sapiens_hsa046120.78536678
54Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.77589551
55Nucleotide excision repair_Homo sapiens_hsa034200.77509937
56Glutathione metabolism_Homo sapiens_hsa004800.77466331
57Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.75653561
58Base excision repair_Homo sapiens_hsa034100.74633602
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.74528317
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73992344
61T cell receptor signaling pathway_Homo sapiens_hsa046600.72790165
62TNF signaling pathway_Homo sapiens_hsa046680.72648462
63Pyruvate metabolism_Homo sapiens_hsa006200.70864171
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69118784
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68920950
66PPAR signaling pathway_Homo sapiens_hsa033200.68782046
67Fructose and mannose metabolism_Homo sapiens_hsa000510.67265568
68Purine metabolism_Homo sapiens_hsa002300.66380817
69Biosynthesis of amino acids_Homo sapiens_hsa012300.65910497
70Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.64529382
71Arachidonic acid metabolism_Homo sapiens_hsa005900.63946420
72Ribosome_Homo sapiens_hsa030100.62658768
73Viral myocarditis_Homo sapiens_hsa054160.58571611
74beta-Alanine metabolism_Homo sapiens_hsa004100.58154764
75HTLV-I infection_Homo sapiens_hsa051660.57903872
76Mismatch repair_Homo sapiens_hsa034300.53711119
77PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53560717
78African trypanosomiasis_Homo sapiens_hsa051430.53504310
79Sulfur relay system_Homo sapiens_hsa041220.52215378
80Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.51418534
81Starch and sucrose metabolism_Homo sapiens_hsa005000.48922252
82Protein export_Homo sapiens_hsa030600.48358822
83Other glycan degradation_Homo sapiens_hsa005110.45932865
84Galactose metabolism_Homo sapiens_hsa000520.44820220
85Arginine and proline metabolism_Homo sapiens_hsa003300.43551155
86TGF-beta signaling pathway_Homo sapiens_hsa043500.43023499
87Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.42765844
88DNA replication_Homo sapiens_hsa030300.41082053
89Leishmaniasis_Homo sapiens_hsa051400.39568346
90Pertussis_Homo sapiens_hsa051330.38543280
91One carbon pool by folate_Homo sapiens_hsa006700.38200416
92Glycosaminoglycan degradation_Homo sapiens_hsa005310.38147818
93Carbon metabolism_Homo sapiens_hsa012000.35107735
94Metabolic pathways_Homo sapiens_hsa011000.33768168
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.33490150
96Legionellosis_Homo sapiens_hsa051340.33028283
97Fanconi anemia pathway_Homo sapiens_hsa034600.30980223
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.30319156
99Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30216609
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30202159

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