IFITM9P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of interleukin-17 production (GO:0032740)5.65672587
2DNA deamination (GO:0045006)5.31010620
3negative regulation of B cell apoptotic process (GO:0002903)5.19519173
4response to interferon-beta (GO:0035456)5.14909612
5regulation of memory T cell differentiation (GO:0043380)4.72326701
6rRNA catabolic process (GO:0016075)4.59721099
7regulation of regulatory T cell differentiation (GO:0045589)4.50365262
8positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.46008119
9positive regulation of defense response to virus by host (GO:0002230)4.38573279
10fucose catabolic process (GO:0019317)4.35468879
11L-fucose metabolic process (GO:0042354)4.35468879
12L-fucose catabolic process (GO:0042355)4.35468879
13multicellular organism reproduction (GO:0032504)4.30032392
14positive regulation of antigen processing and presentation (GO:0002579)4.16801161
15regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)4.12512317
16negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.02756649
17negative regulation of cell killing (GO:0031342)4.02756649
18negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.99691814
19regulation of dendritic cell antigen processing and presentation (GO:0002604)3.89849666
20negative regulation of mast cell activation (GO:0033004)3.88741897
21behavioral response to nicotine (GO:0035095)3.85182237
22regulation of germinal center formation (GO:0002634)3.79303468
23platelet dense granule organization (GO:0060155)3.66265491
24protein-cofactor linkage (GO:0018065)3.61754539
25positive regulation of T cell mediated cytotoxicity (GO:0001916)3.61358473
26regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.55735268
27positive regulation of T-helper 1 type immune response (GO:0002827)3.50742367
28negative thymic T cell selection (GO:0045060)3.49285535
29regulation of isotype switching to IgG isotypes (GO:0048302)3.49209009
30RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.48607547
31regulation of T cell mediated cytotoxicity (GO:0001914)3.45504438
32cellular response to exogenous dsRNA (GO:0071360)3.44947011
33negative T cell selection (GO:0043383)3.42289861
34regulation of defense response to virus by host (GO:0050691)3.41062840
35regulation of interleukin-17 production (GO:0032660)3.41016553
36regulation of B cell apoptotic process (GO:0002902)3.40355634
37mannosylation (GO:0097502)3.40210067
38cellular response to interleukin-15 (GO:0071350)3.40118891
39positive thymic T cell selection (GO:0045059)3.38321746
40negative regulation of DNA-templated transcription, elongation (GO:0032785)3.36257850
41negative regulation of lymphocyte apoptotic process (GO:0070229)3.35435366
42response to gravity (GO:0009629)3.34817874
43regulation of immunoglobulin secretion (GO:0051023)3.30257390
44antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.21779664
45response to interferon-alpha (GO:0035455)3.21702011
46nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.18493184
47mast cell activation (GO:0045576)3.17631805
48regulation of antigen processing and presentation (GO:0002577)3.16304557
49mast cell activation involved in immune response (GO:0002279)3.14256952
50mast cell degranulation (GO:0043303)3.14256952
51T-helper cell differentiation (GO:0042093)3.13412279
52CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.13412279
53exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.10855990
54S-adenosylmethionine metabolic process (GO:0046500)3.08679655
55regulation of activation of Janus kinase activity (GO:0010533)3.08674611
56sleep (GO:0030431)3.07720386
57positive regulation of activated T cell proliferation (GO:0042104)3.04470802
58antigen processing and presentation of endogenous antigen (GO:0019883)3.02283296
59cytidine catabolic process (GO:0006216)2.98121405
60cytidine deamination (GO:0009972)2.98121405
61cytidine metabolic process (GO:0046087)2.98121405
62glutathione biosynthetic process (GO:0006750)2.97242189
63rhodopsin mediated signaling pathway (GO:0016056)2.95213560
64regulation of T-helper 1 type immune response (GO:0002825)2.93172839
65positive regulation of T cell differentiation in thymus (GO:0033089)2.89303716
66natural killer cell activation (GO:0030101)2.89116013
67RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.86360212
68tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.86360212
69positive regulation of T cell mediated immunity (GO:0002711)2.85182588
70positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.81610025
71T cell differentiation involved in immune response (GO:0002292)2.81118011
72alpha-beta T cell differentiation involved in immune response (GO:0002293)2.81118011
73alpha-beta T cell activation involved in immune response (GO:0002287)2.81118011
74negative regulation of reactive oxygen species metabolic process (GO:2000378)2.79831305
75response to interleukin-15 (GO:0070672)2.78500238
76regulation of leukocyte mediated cytotoxicity (GO:0001910)2.77106947
77positive regulation of adaptive immune response based on somatic recombination of immune receptors b2.76349719
78preassembly of GPI anchor in ER membrane (GO:0016254)2.75992238
79reproduction (GO:0000003)2.72859559
80negative regulation of leukocyte apoptotic process (GO:2000107)2.70617333
81nonribosomal peptide biosynthetic process (GO:0019184)2.70552023
82positive regulation of adaptive immune response (GO:0002821)2.68198823
83positive regulation of DNA recombination (GO:0045911)2.67810643
84tyrosine phosphorylation of STAT protein (GO:0007260)2.66499423
85purine deoxyribonucleotide catabolic process (GO:0009155)2.65545337
86fusion of sperm to egg plasma membrane (GO:0007342)2.65099103
87regulation of rhodopsin mediated signaling pathway (GO:0022400)2.61988801
88positive regulation of interferon-gamma production (GO:0032729)2.61164693
89endoderm formation (GO:0001706)2.60584167
90negative regulation of viral genome replication (GO:0045071)2.59115222
91interferon-gamma production (GO:0032609)2.56049312
92positive regulation of isotype switching (GO:0045830)2.55488051
93pyrimidine ribonucleoside catabolic process (GO:0046133)2.55345689
94regulation of gamma-delta T cell differentiation (GO:0045586)2.53584969
95regulation of T cell receptor signaling pathway (GO:0050856)2.52558291
96somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.49135631
97isotype switching (GO:0045190)2.49135631
98somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.49135631
99thymic T cell selection (GO:0045061)2.48830435
100cellular response to interferon-beta (GO:0035458)2.48234808

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.41399500
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.81691565
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.87016882
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.77050880
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.61767450
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.49826781
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.20199406
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.97881330
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.81851956
10ZNF274_21170338_ChIP-Seq_K562_Hela2.81622781
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.72408971
12RUNX_20019798_ChIP-Seq_JUKART_Human2.54680521
13NOTCH1_21737748_ChIP-Seq_TLL_Human2.39515242
14GATA3_26560356_Chip-Seq_TH2_Human2.33278522
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.32119883
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.23600093
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.12152721
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.05921173
19MYB_26560356_Chip-Seq_TH2_Human1.99488362
20IRF8_21731497_ChIP-ChIP_J774_Mouse1.99289792
21PCGF2_27294783_Chip-Seq_ESCs_Mouse1.94279483
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.92812629
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.91704399
24VDR_23849224_ChIP-Seq_CD4+_Human1.89531681
25GATA3_27048872_Chip-Seq_THYMUS_Human1.85051540
26CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.83725413
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.82059382
28PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.78831184
29LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.78204447
30RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.72802938
31TP53_22573176_ChIP-Seq_HFKS_Human1.67124312
32SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.66933636
33MYC_18940864_ChIP-ChIP_HL60_Human1.59574175
34ELK1_19687146_ChIP-ChIP_HELA_Human1.55359160
35EST1_17652178_ChIP-ChIP_JURKAT_Human1.55170118
36FOXP3_21729870_ChIP-Seq_TREG_Human1.51719724
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.51718720
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.49376580
39EGR1_23403033_ChIP-Seq_LIVER_Mouse1.48224956
40EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.43798838
41CIITA_25753668_ChIP-Seq_RAJI_Human1.43719053
42LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.42233941
43MYB_26560356_Chip-Seq_TH1_Human1.39070654
44SPI1_23547873_ChIP-Seq_NB4_Human1.37767977
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.36662412
46AUTS2_25519132_ChIP-Seq_293T-REX_Human1.35909492
47AR_20517297_ChIP-Seq_VCAP_Human1.34857342
48PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33649739
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33221336
50ETS1_20019798_ChIP-Seq_JURKAT_Human1.32511725
51SRF_21415370_ChIP-Seq_HL-1_Mouse1.32379747
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.28142424
53EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.27190834
54GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.26284117
55STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.25596276
56BCAT_22108803_ChIP-Seq_LS180_Human1.22564524
57BCL6_27268052_Chip-Seq_Bcells_Human1.21672533
58GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.20124367
59CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.19607934
60ERA_21632823_ChIP-Seq_H3396_Human1.17226046
61RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15851337
62TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.15039724
63VDR_22108803_ChIP-Seq_LS180_Human1.12743541
64GATA2_21666600_ChIP-Seq_HMVEC_Human1.11467476
65NANOG_20526341_ChIP-Seq_ESCs_Human1.11299236
66TAF2_19829295_ChIP-Seq_ESCs_Human1.09175445
67IRF1_19129219_ChIP-ChIP_H3396_Human1.06930369
68NANOG_19829295_ChIP-Seq_ESCs_Human1.06688183
69SOX2_19829295_ChIP-Seq_ESCs_Human1.06688183
70NFE2_27457419_Chip-Seq_LIVER_Mouse1.05144090
71RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.03756741
72FOXA1_25329375_ChIP-Seq_VCAP_Human1.03676279
73FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03676279
74GATA4_25053715_ChIP-Seq_YYC3_Human1.02973643
75STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.02797619
76FOXH1_21741376_ChIP-Seq_EPCs_Human1.02459211
77HOXB4_20404135_ChIP-ChIP_EML_Mouse1.02345725
78IRF8_27001747_Chip-Seq_BMDM_Mouse1.01194024
79FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00776258
80RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.00447023
81HOXB7_26014856_ChIP-Seq_BT474_Human0.99184013
82GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.96829801
83VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.96599429
84MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.95545687
85NCOR_22424771_ChIP-Seq_293T_Human0.95430971
86FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.94315746
87RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.92600833
88MAF_26560356_Chip-Seq_TH1_Human0.92097048
89MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.92082605
90FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.92077340
91SUZ12_27294783_Chip-Seq_NPCs_Mouse0.91194614
92PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.90616554
93GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89427786
94CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.88975875
95MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.87755505
96SPI1_20517297_ChIP-Seq_HL60_Human0.87148783
97P300_27268052_Chip-Seq_Bcells_Human0.87002902
98FOXA1_21572438_ChIP-Seq_LNCaP_Human0.86988413
99STAT1_20625510_ChIP-Seq_HELA_Human0.86940063
100EGR1_19032775_ChIP-ChIP_M12_Human0.86826621

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.23344933
2MP0003011_delayed_dark_adaptation4.13938366
3MP0005671_abnormal_response_to3.56114571
4MP0000465_gastrointestinal_hemorrhage3.52480909
5MP0002138_abnormal_hepatobiliary_system3.49840302
6MP0002166_altered_tumor_susceptibility3.37534053
7MP0003724_increased_susceptibility_to2.93478402
8MP0002006_tumorigenesis2.68713495
9MP0006054_spinal_hemorrhage2.68374262
10MP0000372_irregular_coat_pigmentation2.66029651
11MP0005000_abnormal_immune_tolerance2.46536152
12MP0003763_abnormal_thymus_physiology2.42403798
13MP0003806_abnormal_nucleotide_metabolis2.35967920
14MP0002148_abnormal_hypersensitivity_rea2.29209986
15MP0003195_calcinosis2.27442033
16MP0005075_abnormal_melanosome_morpholog2.13430754
17MP0003191_abnormal_cellular_cholesterol2.09873413
18MP0003436_decreased_susceptibility_to2.03366529
19MP0001800_abnormal_humoral_immune2.01592655
20MP0002723_abnormal_immune_serum1.97679585
21MP0002009_preneoplasia1.90052280
22MP0009785_altered_susceptibility_to1.90017426
23MP0001790_abnormal_immune_system1.89706269
24MP0005387_immune_system_phenotype1.89706269
25MP0008872_abnormal_physiological_respon1.88273983
26MP0001819_abnormal_immune_cell1.84831321
27MP0002420_abnormal_adaptive_immunity1.84009537
28MP0005253_abnormal_eye_physiology1.73049825
29MP0000685_abnormal_immune_system1.71874495
30MP0002452_abnormal_antigen_presenting1.67735362
31MP0005025_abnormal_response_to1.67491240
32MP0004043_abnormal_pH_regulation1.66236411
33MP0010368_abnormal_lymphatic_system1.60647889
34MP0000013_abnormal_adipose_tissue1.58838155
35MP0002933_joint_inflammation1.57863546
36MP0002638_abnormal_pupillary_reflex1.57808329
37MP0009333_abnormal_splenocyte_physiolog1.55771314
38MP0001764_abnormal_homeostasis1.54254458
39MP0001986_abnormal_taste_sensitivity1.51818965
40MP0006072_abnormal_retinal_apoptosis1.51597434
41MP0002398_abnormal_bone_marrow1.49949634
42MP0002405_respiratory_system_inflammati1.48610917
43MP0001853_heart_inflammation1.43057457
44MP0000689_abnormal_spleen_morphology1.41604471
45MP0009764_decreased_sensitivity_to1.39150644
46MP0005167_abnormal_blood-brain_barrier1.38353762
47MP0000716_abnormal_immune_system1.36834739
48MP0002419_abnormal_innate_immunity1.35659454
49MP0003786_premature_aging1.31965898
50MP0001845_abnormal_inflammatory_respons1.31549736
51MP0001348_abnormal_lacrimal_gland1.27214751
52MP0002722_abnormal_immune_system1.27048638
53MP0001533_abnormal_skeleton_physiology1.25130854
54MP0010155_abnormal_intestine_physiology1.24055110
55MP0001879_abnormal_lymphatic_vessel1.21828261
56MP0008875_abnormal_xenobiotic_pharmacok1.17696523
57MP0002102_abnormal_ear_morphology1.17119030
58MP0002429_abnormal_blood_cell1.15440458
59MP0003252_abnormal_bile_duct1.13958652
60MP0001958_emphysema1.12123847
61MP0005464_abnormal_platelet_physiology1.07738988
62MP0001919_abnormal_reproductive_system1.04373078
63MP0000703_abnormal_thymus_morphology1.03924286
64MP0002876_abnormal_thyroid_physiology1.03023660
65MP0003866_abnormal_defecation1.01068396
66MP0003303_peritoneal_inflammation0.96866722
67MP0005332_abnormal_amino_acid0.95593496
68MP0005551_abnormal_eye_electrophysiolog0.91720202
69MP0005645_abnormal_hypothalamus_physiol0.91095440
70MP0006036_abnormal_mitochondrial_physio0.86957961
71MP0005174_abnormal_tail_pigmentation0.85858340
72MP0008995_early_reproductive_senescence0.82847215
73MP0002396_abnormal_hematopoietic_system0.82061963
74MP0003186_abnormal_redox_activity0.81532394
75MP0008469_abnormal_protein_level0.81326028
76MP0005390_skeleton_phenotype0.80769391
77MP0010329_abnormal_lipoprotein_level0.74727112
78MP0005083_abnormal_biliary_tract0.73039256
79MP0005377_hearing/vestibular/ear_phenot0.71767311
80MP0003878_abnormal_ear_physiology0.71767311
81MP0008775_abnormal_heart_ventricle0.71218327
82MP0001968_abnormal_touch/_nociception0.67358099
83MP0005310_abnormal_salivary_gland0.66773738
84MP0004885_abnormal_endolymph0.65937280
85MP0005389_reproductive_system_phenotype0.65236500
86MP0001501_abnormal_sleep_pattern0.65051549
87MP0003638_abnormal_response/metabolism_0.64788189
88MP0001905_abnormal_dopamine_level0.63626272
89MP0001663_abnormal_digestive_system0.63587989
90MP0001765_abnormal_ion_homeostasis0.63139698
91MP0005084_abnormal_gallbladder_morpholo0.62557295
92MP0008877_abnormal_DNA_methylation0.61333817
93MP0001873_stomach_inflammation0.60859902
94MP0000604_amyloidosis0.60349866
95MP0000613_abnormal_salivary_gland0.58018222
96MP0000538_abnormal_urinary_bladder0.57133281
97MP0003300_gastrointestinal_ulcer0.57057605
98MP0003646_muscle_fatigue0.55636359
99MP0005165_increased_susceptibility_to0.54703597
100MP0003448_altered_tumor_morphology0.54478958

Predicted human phenotypes

RankGene SetZ-score
1Prostate neoplasm (HP:0100787)4.54764921
2IgG deficiency (HP:0004315)4.19637706
3Decreased electroretinogram (ERG) amplitude (HP:0000654)3.83273664
4Severe combined immunodeficiency (HP:0004430)3.76281192
5Myositis (HP:0100614)3.59324447
6Elevated erythrocyte sedimentation rate (HP:0003565)3.45698465
7Hypokalemic alkalosis (HP:0001949)3.40737461
8Metabolic alkalosis (HP:0200114)3.35748423
9Retrobulbar optic neuritis (HP:0100654)3.35460821
10Optic neuritis (HP:0100653)3.35460821
11Abnormality of T cell physiology (HP:0011840)3.32807503
12Abnormal delayed hypersensitivity skin test (HP:0002963)3.22789361
13Bile duct proliferation (HP:0001408)3.18770069
14Abnormal biliary tract physiology (HP:0012439)3.18770069
15Panhypogammaglobulinemia (HP:0003139)3.18652984
16Abnormality of T cells (HP:0002843)3.17463251
17Abnormality of T cell number (HP:0011839)3.16941449
18Stomach cancer (HP:0012126)3.16338452
193-Methylglutaconic aciduria (HP:0003535)3.13902990
20T lymphocytopenia (HP:0005403)3.13183383
21Abolished electroretinogram (ERG) (HP:0000550)3.10837297
22Abnormality of the prostate (HP:0008775)3.08572728
23Type I transferrin isoform profile (HP:0003642)3.05141828
24Retinal dysplasia (HP:0007973)3.05019586
25Orchitis (HP:0100796)3.00096243
26Alkalosis (HP:0001948)2.98170026
27Combined immunodeficiency (HP:0005387)2.90941409
28Thyroiditis (HP:0100646)2.82660947
29Pustule (HP:0200039)2.79519169
30Abnormality of the renal cortex (HP:0011035)2.76640777
31Abnormality of midbrain morphology (HP:0002418)2.75508611
32Molar tooth sign on MRI (HP:0002419)2.75508611
33Dry hair (HP:0011359)2.72401618
34Congenital stationary night blindness (HP:0007642)2.66055899
35Pulmonary fibrosis (HP:0002206)2.62922713
36Hypoproteinemia (HP:0003075)2.60221774
37Congenital, generalized hypertrichosis (HP:0004540)2.55741598
38Anhidrosis (HP:0000970)2.51295648
39Encephalitis (HP:0002383)2.49782762
40Stomatitis (HP:0010280)2.46742166
41Delayed CNS myelination (HP:0002188)2.38398622
42Type 2 muscle fiber atrophy (HP:0003554)2.37393729
43Renal cortical cysts (HP:0000803)2.35963792
44Renal duplication (HP:0000075)2.35012150
45Hypomagnesemia (HP:0002917)2.31584158
46Abnormality of eosinophils (HP:0001879)2.31043729
47Dyschromatopsia (HP:0007641)2.30833971
48Conical tooth (HP:0000698)2.30230992
49Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.24923430
50Abnormal protein N-linked glycosylation (HP:0012347)2.24923430
51Abnormal protein glycosylation (HP:0012346)2.24923430
52Abnormal glycosylation (HP:0012345)2.24923430
53Pulmonary infiltrates (HP:0002113)2.23199471
54Recurrent cutaneous fungal infections (HP:0011370)2.22535383
55Chronic mucocutaneous candidiasis (HP:0002728)2.22535383
56Abnormality of magnesium homeostasis (HP:0004921)2.18992500
57Recurrent fungal infections (HP:0002841)2.18847197
58Abnormality of B cell number (HP:0010975)2.18157626
59Muscle fiber atrophy (HP:0100295)2.15303179
60Increased IgM level (HP:0003496)2.11818879
61Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.11064614
62Severe visual impairment (HP:0001141)2.04902005
63Pancreatic cysts (HP:0001737)2.01722415
64Polyuria (HP:0000103)2.01590246
65Tetany (HP:0001281)1.98143537
66Keratoconjunctivitis sicca (HP:0001097)1.96218580
67Leukocytosis (HP:0001974)1.95950728
68Ketosis (HP:0001946)1.94231684
69Abnormality of the phalanges of the 5th finger (HP:0004213)1.94144438
70Keratoconjunctivitis (HP:0001096)1.92117380
71Dicarboxylic aciduria (HP:0003215)1.91956193
72Abnormality of dicarboxylic acid metabolism (HP:0010995)1.91956193
73Mediastinal lymphadenopathy (HP:0100721)1.90665088
74Eosinophilia (HP:0001880)1.89773567
75Hypoplasia of the uterus (HP:0000013)1.89608883
76Hyperammonemia (HP:0001987)1.86095956
77Aplasia/hypoplasia of the uterus (HP:0008684)1.85340273
78Abnormal rod and cone electroretinograms (HP:0008323)1.84553138
79Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.84242001
80Short middle phalanx of the 5th finger (HP:0004220)1.84089831
81Meningitis (HP:0001287)1.83497051
82Mesomelia (HP:0003027)1.80286026
83Pancreatitis (HP:0001733)1.79514628
84Albinism (HP:0001022)1.77760198
85Broad-based gait (HP:0002136)1.77353455
86Cortical visual impairment (HP:0100704)1.76448667
87Hemoptysis (HP:0002105)1.75949967
88Type II lissencephaly (HP:0007260)1.73928569
89Neutropenia (HP:0001875)1.72960227
90Brushfield spots (HP:0001088)1.72936747
91Recurrent abscess formation (HP:0002722)1.71853098
92Abnormality of DNA repair (HP:0003254)1.71714272
93Decreased central vision (HP:0007663)1.70603944
94Opisthotonus (HP:0002179)1.69207113
95Large for gestational age (HP:0001520)1.68904714
96Chronic hepatic failure (HP:0100626)1.68738495
97Methylmalonic acidemia (HP:0002912)1.67943454
98Facial diplegia (HP:0001349)1.67266739
99Oral leukoplakia (HP:0002745)1.65300181
100Fair hair (HP:0002286)1.64842746

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.05707444
2FES4.03040155
3ZAK3.15588912
4KIT2.94862100
5TESK22.78057089
6TLK12.70391050
7MUSK2.68877165
8KDR2.46178196
9ADRBK22.33899642
10PINK12.32099340
11MST42.11045512
12GRK12.03573724
13MAP2K22.02717261
14IKBKE1.99028284
15TAOK31.96655440
16MAP4K11.79219585
17IKBKB1.77683870
18NUAK11.75961335
19CSF1R1.71457204
20WNK41.68091337
21JAK31.63988730
22PHKG21.60862459
23PHKG11.60862459
24MAP3K141.56946767
25TBK11.54018422
26VRK21.53572259
27FRK1.50822444
28GRK61.48492730
29SIK31.45426307
30EIF2AK31.38000851
31JAK11.37128053
32FER1.36765897
33ITK1.35788192
34CSK1.35528065
35TYK21.28281310
36MAPK111.16154836
37MARK31.10059200
38BRSK21.10015793
39SYK1.05811696
40HCK1.04622296
41TEC1.03543629
42LCK0.99826575
43LYN0.98782912
44CDK80.97147149
45OXSR10.96386849
46MAPKAPK30.92010646
47PRKCQ0.89327223
48MATK0.89296803
49EIF2AK20.89047107
50BMPR1B0.87146187
51CDC70.84027065
52SCYL20.81957958
53NLK0.77388348
54TIE10.76907576
55IGF1R0.76597573
56ADRBK10.75722356
57MAP4K20.73013488
58PIM10.71810671
59TESK10.70712754
60PIK3CA0.69494872
61ZAP700.68793119
62MYLK0.67932349
63STK390.65972264
64RPS6KA50.64564776
65DAPK10.64537027
66SIK20.64322984
67LRRK20.63716378
68PDK20.62262673
69GRK50.62111361
70LIMK10.60754749
71BCKDK0.58967777
72PLK40.57511876
73STK100.51371213
74IRAK40.51014139
75TNK20.50944828
76MAP3K110.50429974
77ATR0.49981201
78TYRO30.49651640
79INSRR0.49211378
80PLK20.49199662
81EIF2AK10.44338027
82ABL10.42623610
83CAMKK10.41740739
84BTK0.39856338
85CAMKK20.38729681
86MAPKAPK50.38708294
87VRK10.38232030
88MAPK40.37793821
89INSR0.36967773
90PRKCI0.36827135
91EGFR0.36419710
92WNK30.36353799
93EPHB20.35307925
94MAP2K60.33689292
95MAPKAPK20.33039491
96MAPK70.32846514
97CHEK20.31466600
98CLK10.30513081
99BMPR20.29309743
100SRPK10.29236639

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.75240372
2Proteasome_Homo sapiens_hsa030503.48680861
3Intestinal immune network for IgA production_Homo sapiens_hsa046723.39991872
4Allograft rejection_Homo sapiens_hsa053303.36464316
5Autoimmune thyroid disease_Homo sapiens_hsa053203.34455354
6Asthma_Homo sapiens_hsa053103.00187754
7Primary immunodeficiency_Homo sapiens_hsa053402.85174171
8Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.74799618
9Nitrogen metabolism_Homo sapiens_hsa009102.73812794
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.60814250
11Type I diabetes mellitus_Homo sapiens_hsa049402.38256709
12Antigen processing and presentation_Homo sapiens_hsa046122.32050866
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.13620010
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.09259549
15Rheumatoid arthritis_Homo sapiens_hsa053231.77788988
16Linoleic acid metabolism_Homo sapiens_hsa005911.74840583
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.73090209
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.65765402
19Hematopoietic cell lineage_Homo sapiens_hsa046401.64975082
20RNA degradation_Homo sapiens_hsa030181.62632820
21Cyanoamino acid metabolism_Homo sapiens_hsa004601.51216019
22Oxidative phosphorylation_Homo sapiens_hsa001901.47902393
23SNARE interactions in vesicular transport_Homo sapiens_hsa041301.37352491
24Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.33466912
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27780167
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.26405715
27RNA polymerase_Homo sapiens_hsa030201.25771750
28Peroxisome_Homo sapiens_hsa041461.24523094
29Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.24519756
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.22546726
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.20352624
32Arachidonic acid metabolism_Homo sapiens_hsa005901.19413989
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.14321683
34Viral myocarditis_Homo sapiens_hsa054161.12084514
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.09283036
36Parkinsons disease_Homo sapiens_hsa050121.08925441
37Sulfur metabolism_Homo sapiens_hsa009201.08355117
38Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.05992481
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.04273568
40Basal transcription factors_Homo sapiens_hsa030221.03912450
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02470563
42Fatty acid biosynthesis_Homo sapiens_hsa000611.01810831
43Measles_Homo sapiens_hsa051621.01033414
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.00094509
45Staphylococcus aureus infection_Homo sapiens_hsa051501.00005976
46Leishmaniasis_Homo sapiens_hsa051400.96806256
47Herpes simplex infection_Homo sapiens_hsa051680.94451815
48Caffeine metabolism_Homo sapiens_hsa002320.90459710
49Ribosome_Homo sapiens_hsa030100.88687671
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.88321794
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82500765
52Regulation of autophagy_Homo sapiens_hsa041400.81979721
53T cell receptor signaling pathway_Homo sapiens_hsa046600.81063197
54NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78236594
55Ether lipid metabolism_Homo sapiens_hsa005650.78103521
56Retinol metabolism_Homo sapiens_hsa008300.77718981
57Protein export_Homo sapiens_hsa030600.77452205
58Phototransduction_Homo sapiens_hsa047440.74958044
59One carbon pool by folate_Homo sapiens_hsa006700.73813575
60Nucleotide excision repair_Homo sapiens_hsa034200.69585414
61Base excision repair_Homo sapiens_hsa034100.68138448
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68135089
63Chemical carcinogenesis_Homo sapiens_hsa052040.67023538
64Tryptophan metabolism_Homo sapiens_hsa003800.66382689
65Purine metabolism_Homo sapiens_hsa002300.66340710
66Collecting duct acid secretion_Homo sapiens_hsa049660.62475405
67Olfactory transduction_Homo sapiens_hsa047400.61798709
68Legionellosis_Homo sapiens_hsa051340.60088236
69Homologous recombination_Homo sapiens_hsa034400.59016055
70Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57552151
71Alzheimers disease_Homo sapiens_hsa050100.55704240
72Pyrimidine metabolism_Homo sapiens_hsa002400.55156944
73TNF signaling pathway_Homo sapiens_hsa046680.53614749
74Epstein-Barr virus infection_Homo sapiens_hsa051690.49770313
75Glutathione metabolism_Homo sapiens_hsa004800.46486148
76Malaria_Homo sapiens_hsa051440.46415277
77Huntingtons disease_Homo sapiens_hsa050160.43458098
78Fatty acid degradation_Homo sapiens_hsa000710.42259709
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40768822
80Fatty acid metabolism_Homo sapiens_hsa012120.40517964
81Apoptosis_Homo sapiens_hsa042100.39028544
82Systemic lupus erythematosus_Homo sapiens_hsa053220.37940582
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37359370
84Pertussis_Homo sapiens_hsa051330.36639789
85Tuberculosis_Homo sapiens_hsa051520.35732999
86Morphine addiction_Homo sapiens_hsa050320.33766763
87Pyruvate metabolism_Homo sapiens_hsa006200.33285555
88Fanconi anemia pathway_Homo sapiens_hsa034600.32781678
89Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.31057097
90N-Glycan biosynthesis_Homo sapiens_hsa005100.30915941
91Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.26466940
92Propanoate metabolism_Homo sapiens_hsa006400.24541841
93Glycosaminoglycan degradation_Homo sapiens_hsa005310.23771309
94Toxoplasmosis_Homo sapiens_hsa051450.23513604
95B cell receptor signaling pathway_Homo sapiens_hsa046620.23458344
96Osteoclast differentiation_Homo sapiens_hsa043800.23113831
97Metabolic pathways_Homo sapiens_hsa011000.21665220
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.17780175
99Fat digestion and absorption_Homo sapiens_hsa049750.17753578
100Folate biosynthesis_Homo sapiens_hsa007900.15584360

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