IFNA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is produced by macrophages and has antiviral activity. This gene is intronless and the encoded protein is secreted. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to interferon-beta (GO:0035458)9.78161492
2cellular response to interferon-alpha (GO:0035457)9.36670272
3response to interferon-beta (GO:0035456)8.29682573
4negative regulation of viral genome replication (GO:0045071)8.29090719
5negative regulation of type 2 immune response (GO:0002829)8.28983107
6response to interferon-alpha (GO:0035455)7.92193164
7* regulation of type I interferon-mediated signaling pathway (GO:0060338)7.30168254
8negative regulation of T cell mediated immunity (GO:0002710)6.76118684
9regulation of dendritic cell antigen processing and presentation (GO:0002604)6.58163999
10regulation of T cell cytokine production (GO:0002724)6.42657887
11* response to exogenous dsRNA (GO:0043330)6.31327893
12cellular response to virus (GO:0098586)6.29821701
13T cell migration (GO:0072678)6.09658314
14cellular response to dsRNA (GO:0071359)5.70429370
15regulation of viral genome replication (GO:0045069)5.65016315
16* defense response to virus (GO:0051607)5.56559364
17positive regulation of interferon-alpha production (GO:0032727)5.50206647
18regulation of hypersensitivity (GO:0002883)5.42699481
19regulation of type 2 immune response (GO:0002828)5.24659780
20regulation of interferon-beta biosynthetic process (GO:0045357)5.23164470
21regulation of interferon-alpha production (GO:0032647)5.15412673
22* response to dsRNA (GO:0043331)4.87502738
23negative regulation of viral process (GO:0048525)4.82110301
24positive regulation of antigen processing and presentation (GO:0002579)4.69222261
25positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.65965499
26regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033394.57412368
27negative thymic T cell selection (GO:0045060)4.56085174
28negative regulation of cytokine production involved in immune response (GO:0002719)4.52375659
29lymphocyte chemotaxis (GO:0048247)4.38417696
30lymphocyte migration (GO:0072676)4.37155072
31interferon-gamma-mediated signaling pathway (GO:0060333)4.36688219
32positive regulation of cAMP-mediated signaling (GO:0043950)4.35207329
33* B cell proliferation (GO:0042100)4.31877624
34regulation of RIG-I signaling pathway (GO:0039535)4.24609613
35mesenchymal cell differentiation involved in renal system development (GO:2001012)4.24260803
36mesenchymal cell differentiation involved in kidney development (GO:0072161)4.24260803
37regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)4.19217490
38negative T cell selection (GO:0043383)4.18905228
39positive regulation of pseudopodium assembly (GO:0031274)4.13599106
40antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.07748559
41positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.00522883
42* natural killer cell activation (GO:0030101)3.95894087
43positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.94142441
44regulation of acute inflammatory response to antigenic stimulus (GO:0002864)3.90936480
45negative regulation of metanephros development (GO:0072217)3.88265052
46antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.87164327
47* T cell activation involved in immune response (GO:0002286)3.85810524
48cell proliferation involved in metanephros development (GO:0072203)3.81378613
49positive regulation of interferon-beta production (GO:0032728)3.76968730
50immunoglobulin mediated immune response (GO:0016064)3.73584626
51regulation of antigen processing and presentation (GO:0002577)3.72230235
52cell differentiation involved in metanephros development (GO:0072202)3.70513248
53negative regulation of production of molecular mediator of immune response (GO:0002701)3.69421536
54regulation of pseudopodium assembly (GO:0031272)3.68651031
55antigen processing and presentation of endogenous antigen (GO:0019883)3.67108898
56response to nitric oxide (GO:0071731)3.66801593
57regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.66174591
58positive regulation of humoral immune response (GO:0002922)3.66008637
59* response to virus (GO:0009615)3.44529709
60response to prostaglandin E (GO:0034695)3.43715367
61positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.37582188
62positive regulation of glycoprotein biosynthetic process (GO:0010560)3.37382813
63positive regulation of type 2 immune response (GO:0002830)3.29836551
64dendritic cell chemotaxis (GO:0002407)3.29673547
65negative regulation of defense response to virus (GO:0050687)3.26118009
66positive regulation by symbiont of host defense response (GO:0052509)3.21923436
67modulation by symbiont of host defense response (GO:0052031)3.21923436
68modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.21923436
69modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.21923436
70positive regulation by organism of defense response of other organism involved in symbiotic interact3.21923436
71modulation by symbiont of host immune response (GO:0052553)3.21923436
72negative regulation of lymphocyte mediated immunity (GO:0002707)3.15986070
73cellular response to interferon-gamma (GO:0071346)3.15685337
74negative regulation of multi-organism process (GO:0043901)3.13607228
75thymic T cell selection (GO:0045061)3.09538952
76positive regulation of T cell cytokine production (GO:0002726)3.05330764
77negative regulation of bone remodeling (GO:0046851)3.02771163
78chemokine-mediated signaling pathway (GO:0070098)3.02118694
79negative regulation of T cell differentiation (GO:0045581)3.00278284
80regulation of interferon-beta production (GO:0032648)2.96894355
81B cell mediated immunity (GO:0019724)2.94159959
82positive regulation of protein homooligomerization (GO:0032464)2.85984763
83regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.85504341
84macrophage activation involved in immune response (GO:0002281)2.82453525
85response to interferon-gamma (GO:0034341)2.81870803
86positive regulation of glycoprotein metabolic process (GO:1903020)2.80628904
87response to host (GO:0075136)2.80448804
88response to host defenses (GO:0052200)2.80448804
89response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.80448804
90response to hydroperoxide (GO:0033194)2.80186650
91negative regulation of bone resorption (GO:0045779)2.79821123
92response to host immune response (GO:0052572)2.78169210
93* positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)16.7354403
94* regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)16.7354403
95* regulation of MHC class I biosynthetic process (GO:0045343)12.3500468
96* natural killer cell activation involved in immune response (GO:0002323)11.2828336
97cellular response to exogenous dsRNA (GO:0071360)10.9002088
98* type I interferon signaling pathway (GO:0060337)10.8458894
99* cellular response to type I interferon (GO:0071357)10.8458894
100* response to type I interferon (GO:0034340)10.6534853

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF1_21803131_ChIP-Seq_MONOCYTES_Human9.02808681
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.41054243
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse6.14026114
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.69290545
5SMAD_19615063_ChIP-ChIP_OVARY_Human5.46840953
6GATA1_22025678_ChIP-Seq_K562_Human3.89457432
7RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.10476536
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.02990412
9* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.68497716
10NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human2.09658451
11SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.09557956
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.07028458
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.01141304
14IRF8_22096565_ChIP-ChIP_GC-B_Human12.4152606
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.99128525
16* MYB_26560356_Chip-Seq_TH2_Human1.82173488
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.80570041
18EGR1_19374776_ChIP-ChIP_THP-1_Human1.70104733
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.63876856
20MYB_21317192_ChIP-Seq_ERMYB_Mouse1.59180322
21STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.56430255
22MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.56306194
23MAF_26560356_Chip-Seq_TH1_Human1.43584279
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38658337
25GATA2_21666600_ChIP-Seq_HMVEC_Human1.29944977
26MYB_26560356_Chip-Seq_TH1_Human1.29021498
27SPI1_23547873_ChIP-Seq_NB4_Human1.26236316
28VDR_24787735_ChIP-Seq_THP-1_Human1.17054264
29PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16300284
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.12632430
31GATA3_26560356_Chip-Seq_TH2_Human1.10107174
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.08855365
33VDR_24763502_ChIP-Seq_THP-1_Human1.06883298
34DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.04481251
35GATA3_27048872_Chip-Seq_THYMUS_Human1.03373140
36CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.02060064
37Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.96015088
38SOX2_20726797_ChIP-Seq_SW620_Human0.89895546
39CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.88233698
40PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87649744
41FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.87342400
42SPI1_23127762_ChIP-Seq_K562_Human0.86139708
43NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.85169419
44MAF_26560356_Chip-Seq_TH2_Human0.84131235
45BRD4_25478319_ChIP-Seq_HGPS_Human0.83227224
46RUNX1_22412390_ChIP-Seq_EML_Mouse0.82788646
47TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82309757
48CJUN_26792858_Chip-Seq_BT549_Human0.81445790
49ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.79551072
50CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79438773
51TRIM28_21343339_ChIP-Seq_HEK293_Human0.77454441
52IKZF1_21737484_ChIP-ChIP_HCT116_Human0.77103352
53ELF5_23300383_ChIP-Seq_T47D_Human0.75745353
54PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.75680297
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.75294723
56ZNF263_19887448_ChIP-Seq_K562_Human0.74556085
57PU_27001747_Chip-Seq_BMDM_Mouse0.74388851
58THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.73904006
59STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.71163995
60SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.70698477
61SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.70698477
62GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.67988686
63RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.67468070
64RUNX1_26923725_Chip-Seq_HPCs_Mouse0.66900919
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.66646849
66RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.66620061
67AUTS2_25519132_ChIP-Seq_293T-REX_Human0.66245582
68TP53_18474530_ChIP-ChIP_U2OS_Human0.63812914
69SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.62097610
70RUNX_20019798_ChIP-Seq_JUKART_Human0.61874114
71EGR1_23403033_ChIP-Seq_LIVER_Mouse0.60846762
72AHR_22903824_ChIP-Seq_MCF-7_Human0.60736877
73BRD4_27068464_Chip-Seq_AML-cells_Mouse0.60383141
74TP63_19390658_ChIP-ChIP_HaCaT_Human0.59946002
75UTX_26944678_Chip-Seq_JUKART_Human0.59134027
76FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.58983498
77CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.58848370
78FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.58085074
79ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.57736106
80* SMRT_27268052_Chip-Seq_Bcells_Human0.57653863
81PCGF2_27294783_Chip-Seq_NPCs_Mouse0.56663388
82GATA2_22383799_ChIP-Seq_G1ME_Mouse0.56632435
83JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.53366682
84GF1_26923725_Chip-Seq_HPCs_Mouse0.52664113
85RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.52459039
86TFEB_21752829_ChIP-Seq_HELA_Human0.52011163
87PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.51048142
88JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.50950666
89SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.50860541
90MYC_22102868_ChIP-Seq_BL_Human0.50779569
91HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.48972742
92CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.48830812
93SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.48523744
94IRF1_19129219_ChIP-ChIP_H3396_Human0.47638424
95SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.47240575
96ARNT_22903824_ChIP-Seq_MCF-7_Human0.46026872
97* CDX2_22108803_ChIP-Seq_LS180_Human0.45538038
98ELK3_25401928_ChIP-Seq_HUVEC_Human0.45104041
99FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.44937639
100POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.44557979

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006082_CNS_inflammation7.46633255
2MP0001348_abnormal_lacrimal_gland6.38863744
3MP0002163_abnormal_gland_morphology5.58939974
4MP0001346_abnormal_lacrimal_gland5.15847901
5MP0001835_abnormal_antigen_presentation4.60129881
6MP0009785_altered_susceptibility_to4.17289110
7MP0003303_peritoneal_inflammation3.64313891
8MP0003724_increased_susceptibility_to3.57447882
9MP0005379_endocrine/exocrine_gland_phen3.30548181
10MP0003690_abnormal_glial_cell2.70375727
11MP0005000_abnormal_immune_tolerance2.56213521
12MP0005025_abnormal_response_to2.42265152
13MP0001800_abnormal_humoral_immune2.37562782
14MP0002166_altered_tumor_susceptibility2.34362611
15MP0005310_abnormal_salivary_gland2.21275489
16MP0000613_abnormal_salivary_gland2.20655737
17MP0002148_abnormal_hypersensitivity_rea2.19445719
18MP0002138_abnormal_hepatobiliary_system1.90466189
19MP0002723_abnormal_immune_serum1.88882534
20MP0000537_abnormal_urethra_morphology1.84980163
21MP0010030_abnormal_orbit_morphology1.84325096
22MP0003448_altered_tumor_morphology1.81577896
23MP0000516_abnormal_urinary_system1.80650892
24MP0005367_renal/urinary_system_phenotyp1.80650892
25MP0002452_abnormal_antigen_presenting1.79744577
26MP0002254_reproductive_system_inflammat1.78067073
27MP0008469_abnormal_protein_level1.76262528
28MP0003091_abnormal_cell_migration1.67139370
29MP0005387_immune_system_phenotype1.66232311
30MP0001790_abnormal_immune_system1.66232311
31MP0009333_abnormal_splenocyte_physiolog1.63737183
32MP0003315_abnormal_perineum_morphology1.62226243
33MP0009840_abnormal_foam_cell1.61194394
34MP0002006_tumorigenesis1.59675843
35MP0001873_stomach_inflammation1.39776484
36MP0001819_abnormal_immune_cell1.39612672
37MP0002419_abnormal_innate_immunity1.39543248
38MP0002420_abnormal_adaptive_immunity1.38380618
39MP0003221_abnormal_cardiomyocyte_apopto1.28472763
40MP0000716_abnormal_immune_system1.25530812
41MP0000920_abnormal_myelination1.24821317
42MP0001845_abnormal_inflammatory_respons1.19806862
43MP0002398_abnormal_bone_marrow1.19467913
44MP0005451_abnormal_body_composition1.16103116
45MP0005671_abnormal_response_to1.14824073
46MP0000343_altered_response_to1.12865635
47MP0000685_abnormal_immune_system1.09491968
48MP0005623_abnormal_meninges_morphology1.09268498
49MP0002405_respiratory_system_inflammati1.08800191
50MP0002653_abnormal_ependyma_morphology1.06438434
51MP0008438_abnormal_cutaneous_collagen1.04430226
52MP0002429_abnormal_blood_cell0.97058567
53MP0002751_abnormal_autonomic_nervous0.96931998
54MP0010155_abnormal_intestine_physiology0.95050602
55MP0003763_abnormal_thymus_physiology0.93472646
56MP0000689_abnormal_spleen_morphology0.92767217
57MP0009763_increased_sensitivity_to0.87423257
58MP0005187_abnormal_penis_morphology0.84353239
59MP0003172_abnormal_lysosome_physiology0.84111652
60MP0003300_gastrointestinal_ulcer0.82740480
61MP0008872_abnormal_physiological_respon0.82711194
62MP0002282_abnormal_trachea_morphology0.80158367
63MP0004947_skin_inflammation0.78224167
64MP0003186_abnormal_redox_activity0.72280045
65MP0000538_abnormal_urinary_bladder0.68559454
66MP0000703_abnormal_thymus_morphology0.67903281
67MP0003436_decreased_susceptibility_to0.65340819
68MP0000767_abnormal_smooth_muscle0.65075027
69MP0002722_abnormal_immune_system0.64774241
70MP0002877_abnormal_melanocyte_morpholog0.63751037
71MP0005275_abnormal_skin_tensile0.63112427
72MP0003950_abnormal_plasma_membrane0.60772471
73MP0009764_decreased_sensitivity_to0.60734613
74MP0005464_abnormal_platelet_physiology0.60302905
75MP0003795_abnormal_bone_structure0.60194663
76MP0001533_abnormal_skeleton_physiology0.60124897
77MP0004510_myositis0.58177946
78MP0002998_abnormal_bone_remodeling0.57262161
79MP0005084_abnormal_gallbladder_morpholo0.55694568
80MP0003866_abnormal_defecation0.53976045
81MP0003045_fibrosis0.48754617
82MP0005197_abnormal_uvea_morphology0.47276338
83MP0003191_abnormal_cellular_cholesterol0.44858675
84MP0008874_decreased_physiological_sensi0.44282286
85MP0000858_altered_metastatic_potential0.44080160
86MP0005621_abnormal_cell_physiology0.42817736
87MP0001915_intracranial_hemorrhage0.42057810
88MP0001663_abnormal_digestive_system0.41058150
89MP0003806_abnormal_nucleotide_metabolis0.40674024
90MP0005645_abnormal_hypothalamus_physiol0.39668398
91MP0003828_pulmonary_edema0.38323146
92MP0002396_abnormal_hematopoietic_system0.38203362
93MP0009250_abnormal_appendicular_skeleto0.36046520
94MP0000534_abnormal_ureter_morphology0.35570682
95MP0003943_abnormal_hepatobiliary_system0.35440705
96MP0000569_abnormal_digit_pigmentation0.33434135
97MP0005390_skeleton_phenotype0.32860113
98MP0002928_abnormal_bile_duct0.32803456
99MP0005075_abnormal_melanosome_morpholog0.31161310
100MP0003566_abnormal_cell_adhesion0.29986127

Predicted human phenotypes

RankGene SetZ-score
1Chronic mucocutaneous candidiasis (HP:0002728)7.61902646
2Recurrent cutaneous fungal infections (HP:0011370)7.61902646
3Short 1st metacarpal (HP:0010034)5.60361991
4Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)5.60361991
5Recurrent viral infections (HP:0004429)5.42765214
6Chronic otitis media (HP:0000389)5.37211609
7Cheilitis (HP:0100825)5.06422992
8Abnormality of the 1st metacarpal (HP:0010009)4.89524436
9Abnormality of the 2nd finger (HP:0004100)4.73121481
10Spinal cord lesions (HP:0100561)4.63885004
11Syringomyelia (HP:0003396)4.63885004
12Septate vagina (HP:0001153)4.57553673
13Abnormal tarsal ossification (HP:0008369)4.48329381
14Spontaneous abortion (HP:0005268)4.31843952
15Recurrent fungal infections (HP:0002841)3.92956029
16Cleft eyelid (HP:0000625)3.80931914
17Nasal polyposis (HP:0100582)3.74322276
18Recurrent skin infections (HP:0001581)3.68711072
193-Methylglutaconic aciduria (HP:0003535)3.52807202
20Loss of speech (HP:0002371)3.49556950
21Ureteral stenosis (HP:0000071)3.47687320
22Unilateral renal agenesis (HP:0000122)3.47553330
23Porencephaly (HP:0002132)3.41093664
24Abnormal foot bone ossification (HP:0010675)3.40639805
25Increased IgM level (HP:0003496)3.38890339
26Abnormality of the nasal mucosa (HP:0000433)3.38806993
27Abnormality of carpal bone ossification (HP:0006257)3.33365835
28Ureteral obstruction (HP:0006000)3.31480147
29Short phalanx of the thumb (HP:0009660)3.18676142
30Spondylolisthesis (HP:0003302)3.14567750
31Chronic sinusitis (HP:0011109)3.07525429
32Short 5th finger (HP:0009237)3.06357878
33Recurrent bronchitis (HP:0002837)3.03767397
34Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.77834605
35Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.71662445
36Hypergammaglobulinemia (HP:0010702)2.66015877
37Urticaria (HP:0001025)2.64768974
38Hemoptysis (HP:0002105)2.63857746
39Abnormal delayed hypersensitivity skin test (HP:0002963)2.58607386
40Short hallux (HP:0010109)2.54496932
41Pulmonary infiltrates (HP:0002113)2.51542175
42Aplasia/Hypoplasia of the hallux (HP:0008362)2.51276052
43Abnormal ossification of hand bones (HP:0005921)2.44799672
44Progressive inability to walk (HP:0002505)2.43163677
45Abnormality of the endocardium (HP:0004306)2.41579935
46Abnormal hand bone ossification (HP:0010660)2.38396624
47Dry hair (HP:0011359)2.30705725
48Absent frontal sinuses (HP:0002688)2.27327943
49Gingival bleeding (HP:0000225)2.24061472
50Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.23737117
51Plagiocephaly (HP:0001357)2.22355159
52Deviation of the hallux (HP:0010051)2.18671233
53Vasculitis (HP:0002633)2.16782549
54Osteolytic defects of the phalanges of the hand (HP:0009771)2.15285547
55Osteolytic defects of the hand bones (HP:0009699)2.15285547
56Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.13756278
57Premature loss of primary teeth (HP:0006323)2.12838524
58Abnormality of the musculature of the hand (HP:0001421)2.09345304
59Onycholysis (HP:0001806)2.07989761
60Global brain atrophy (HP:0002283)2.07045970
61Ridged nail (HP:0001807)2.06277878
62Eosinophilia (HP:0001880)2.05028145
63Patellar dislocation (HP:0002999)2.03228464
64Pulmonary artery stenosis (HP:0004415)2.02829981
65Abnormality of the frontal sinuses (HP:0002687)2.02299860
66Basal ganglia calcification (HP:0002135)1.97853655
67Fatigue (HP:0012378)1.97627549
68Albinism (HP:0001022)1.93242103
69Mediastinal lymphadenopathy (HP:0100721)1.92327914
70Eczematoid dermatitis (HP:0000976)1.91596043
71Mitral stenosis (HP:0001718)1.91015101
72Hematochezia (HP:0002573)1.90662335
73Hypertensive crisis (HP:0100735)1.90348275
74Short nail (HP:0001799)1.90033632
75Gingivitis (HP:0000230)1.88495357
76Flat capital femoral epiphysis (HP:0003370)1.88210454
77Skin rash (HP:0000988)1.87054217
78Skin ulcer (HP:0200042)1.86025864
79Flat cornea (HP:0007720)1.85332187
80Personality changes (HP:0000751)1.83034654
81Recurrent bacterial skin infections (HP:0005406)1.82396466
82Septo-optic dysplasia (HP:0100842)1.81848121
83Oral leukoplakia (HP:0002745)1.78730716
84Abnormality of chromosome segregation (HP:0002916)1.77287013
85Cervical subluxation (HP:0003308)1.76750221
86Elfin facies (HP:0004428)1.73483840
87Panhypogammaglobulinemia (HP:0003139)1.70962728
88Synostosis of carpal bones (HP:0005048)1.70686997
89Abnormality of T cell number (HP:0011839)1.68725704
90Abnormality of incisor morphology (HP:0011063)1.67773649
91Thick nail (HP:0001805)1.67300234
92Granulocytopenia (HP:0001913)1.67203107
93Orthostatic hypotension (HP:0001278)1.66101786
94Leukocytosis (HP:0001974)1.64036534
95Abnormality of the phalanges of the 2nd finger (HP:0009541)1.63333375
96Periodontitis (HP:0000704)1.62586419
97Emphysema (HP:0002097)1.61772644
98Dysautonomia (HP:0002459)1.61469371
99Deviation of the thumb (HP:0009603)1.60253370
100Blepharitis (HP:0000498)1.57977947

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR47.60757220
2TYK26.08523807
3IKBKE5.34828350
4KIT4.30955567
5FGFR34.26440398
6JAK34.05753011
7JAK13.55914544
8PIK3CG2.90443854
9TBK12.59881482
10MAPK112.49791322
11MAP4K12.41478157
12SIK32.30597603
13PRPF4B2.12435492
14MATK1.70157104
15TRIB31.64853070
16TAOK31.39987228
17DDR21.37912894
18RIPK41.32827349
19MAP3K141.29899685
20TESK21.27389363
21MAP3K121.13585057
22PRKD31.13315350
23EPHA31.06811492
24TESK11.05920932
25SIK11.04152614
26CHUK1.03975303
27RPS6KA41.02109755
28IKBKB1.01834840
29RPS6KA50.95963063
30EPHB10.91182178
31LATS20.86143754
32TYRO30.84543589
33JAK20.71391672
34GRK70.70070725
35RPS6KB20.69488438
36TNK20.68586861
37NLK0.65195781
38SMG10.61968064
39ILK0.57059216
40SIK20.54916473
41HIPK20.53908197
42DMPK0.51225506
43CLK10.50940106
44CSF1R0.48104636
45ADRBK20.47660723
46NUAK10.44309353
47TAF10.43344040
48MELK0.43341464
49CSNK1A1L0.42439852
50CSNK1G30.42344044
51MST1R0.41667727
52NEK90.41221012
53LCK0.39495843
54PRKD20.38956782
55BMX0.37255410
56FGR0.36692419
57CAMK2G0.36606223
58IRAK40.36091109
59EIF2AK20.35206380
60MAPKAPK20.32674099
61TSSK60.31830073
62PRKCD0.30319178
63MAP3K130.29403605
64EGFR0.28117498
65ZAP700.27994163
66RIPK10.27560762
67MARK30.26354015
68EIF2AK30.26277272
69CDK90.26166697
70STK390.25744319
71CSNK1G20.23713250
72CSNK1G10.23697972
73PRKCQ0.22152606
74CSK0.21020579
75TGFBR20.19677683
76CAMKK20.19310040
77MAPK70.18920653
78MAPK30.17503310
79CDC42BPA0.16784805
80WNK40.15818411
81CDK40.15549734
82OXSR10.14509209
83MAPK100.14502395
84LRRK20.13901652
85ABL10.13339155
86VRK20.12218455
87STK30.11941245
88TEC0.10625268
89LYN0.08834252
90DAPK10.08793678
91MARK20.07962075
92TRIM280.07224675
93PDGFRA0.06963077
94STK100.06880272
95MAPK10.06846183
96MAPK80.06660601
97PDGFRB0.05943275
98MAP2K10.05514795
99HCK0.04195285
100PAK30.03925770

Predicted pathways (KEGG)

RankGene SetZ-score
1* RIG-I-like receptor signaling pathway_Homo sapiens_hsa046225.82063326
2* Measles_Homo sapiens_hsa051624.76341121
3* Cytosolic DNA-sensing pathway_Homo sapiens_hsa046234.57374262
4* Influenza A_Homo sapiens_hsa051644.29622299
5* Toll-like receptor signaling pathway_Homo sapiens_hsa046204.10364865
6* Hepatitis C_Homo sapiens_hsa051603.52887421
7* Herpes simplex infection_Homo sapiens_hsa051683.36336652
8Allograft rejection_Homo sapiens_hsa053302.24874875
9* Hepatitis B_Homo sapiens_hsa051612.18351623
10* Autoimmune thyroid disease_Homo sapiens_hsa053202.11613794
11Graft-versus-host disease_Homo sapiens_hsa053322.02354639
12* Jak-STAT signaling pathway_Homo sapiens_hsa046301.89558763
13Osteoclast differentiation_Homo sapiens_hsa043801.82884317
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.77210847
15Viral myocarditis_Homo sapiens_hsa054161.76486188
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.69878668
17Leishmaniasis_Homo sapiens_hsa051401.57843282
18Toxoplasmosis_Homo sapiens_hsa051451.56765901
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.54813930
20Type I diabetes mellitus_Homo sapiens_hsa049401.53856972
21Antigen processing and presentation_Homo sapiens_hsa046121.51411151
22Pancreatic cancer_Homo sapiens_hsa052121.44943610
23Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.44453100
24Apoptosis_Homo sapiens_hsa042101.41812680
25Chemokine signaling pathway_Homo sapiens_hsa040621.37461544
26* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.35227339
27* Tuberculosis_Homo sapiens_hsa051521.33741874
28* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.30128313
29Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.28839057
30Asthma_Homo sapiens_hsa053101.27210759
31B cell receptor signaling pathway_Homo sapiens_hsa046621.24695933
32Prolactin signaling pathway_Homo sapiens_hsa049171.22144692
33TNF signaling pathway_Homo sapiens_hsa046681.20118157
34Primary immunodeficiency_Homo sapiens_hsa053401.18955476
35Acute myeloid leukemia_Homo sapiens_hsa052211.08326124
36Shigellosis_Homo sapiens_hsa051311.03977713
37AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.98396556
38Epstein-Barr virus infection_Homo sapiens_hsa051690.96779179
39Pertussis_Homo sapiens_hsa051330.92398688
40Viral carcinogenesis_Homo sapiens_hsa052030.72735978
41Small cell lung cancer_Homo sapiens_hsa052220.72116279
42Chronic myeloid leukemia_Homo sapiens_hsa052200.62568400
43Rheumatoid arthritis_Homo sapiens_hsa053230.62337992
44Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61124220
45Proteasome_Homo sapiens_hsa030500.60656750
46T cell receptor signaling pathway_Homo sapiens_hsa046600.57799575
47Neurotrophin signaling pathway_Homo sapiens_hsa047220.57681937
48Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55738116
49Non-small cell lung cancer_Homo sapiens_hsa052230.49612720
50NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48299042
51Legionellosis_Homo sapiens_hsa051340.47024795
52Endometrial cancer_Homo sapiens_hsa052130.44705710
53Phagosome_Homo sapiens_hsa041450.43372570
54Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42055435
55Adipocytokine signaling pathway_Homo sapiens_hsa049200.39964750
56Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.39883118
57African trypanosomiasis_Homo sapiens_hsa051430.39572936
58Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37842277
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37133111
60HTLV-I infection_Homo sapiens_hsa051660.35742639
61Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35730709
622-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.34933610
63Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34225565
64Renal cell carcinoma_Homo sapiens_hsa052110.34092703
65Hematopoietic cell lineage_Homo sapiens_hsa046400.33229105
66Colorectal cancer_Homo sapiens_hsa052100.31443958
67Prostate cancer_Homo sapiens_hsa052150.30656957
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.30029849
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.29157438
70Notch signaling pathway_Homo sapiens_hsa043300.28204006
71Proteoglycans in cancer_Homo sapiens_hsa052050.28015343
72Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.26867263
73Insulin resistance_Homo sapiens_hsa049310.26715014
74Staphylococcus aureus infection_Homo sapiens_hsa051500.26153963
75FoxO signaling pathway_Homo sapiens_hsa040680.25746939
76* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.24860205
77Pathways in cancer_Homo sapiens_hsa052000.23898536
78mTOR signaling pathway_Homo sapiens_hsa041500.23445445
79Salmonella infection_Homo sapiens_hsa051320.23128156
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.22665943
81Central carbon metabolism in cancer_Homo sapiens_hsa052300.21607290
82Platelet activation_Homo sapiens_hsa046110.21076893
83Basal transcription factors_Homo sapiens_hsa030220.20462777
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.19489782
85VEGF signaling pathway_Homo sapiens_hsa043700.18580950
86ABC transporters_Homo sapiens_hsa020100.18363187
87MAPK signaling pathway_Homo sapiens_hsa040100.18281455
88Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.18078518
89Protein export_Homo sapiens_hsa030600.18070251
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.17186037
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.16058347
92Melanoma_Homo sapiens_hsa052180.14917421
93Focal adhesion_Homo sapiens_hsa045100.14026216
94Basal cell carcinoma_Homo sapiens_hsa052170.13841217
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.13144444
96Amoebiasis_Homo sapiens_hsa051460.13060656
97Malaria_Homo sapiens_hsa051440.12466232
98Glioma_Homo sapiens_hsa052140.11357143
99Bladder cancer_Homo sapiens_hsa052190.10675525
100HIF-1 signaling pathway_Homo sapiens_hsa040660.10307807

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