IFNA16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane organization (GO:0097090)9.48296906
2presynaptic membrane assembly (GO:0097105)8.52451568
3negative regulation of synaptic transmission, GABAergic (GO:0032229)5.29945792
4neurotransmitter-gated ion channel clustering (GO:0072578)5.00569335
5daunorubicin metabolic process (GO:0044597)4.55581896
6polyketide metabolic process (GO:0030638)4.55581896
7doxorubicin metabolic process (GO:0044598)4.55581896
8regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.26204029
9positive regulation of cellular amide metabolic process (GO:0034250)4.20836233
10startle response (GO:0001964)4.10119074
11synaptic transmission, glutamatergic (GO:0035249)4.09258497
12regulation of short-term neuronal synaptic plasticity (GO:0048172)4.05769529
13ionotropic glutamate receptor signaling pathway (GO:0035235)4.04914295
14postsynaptic membrane organization (GO:0001941)3.95986381
15regulation of synapse maturation (GO:0090128)3.90753920
16vocalization behavior (GO:0071625)3.88912311
17positive regulation of synapse assembly (GO:0051965)3.86702164
18negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.82351617
19regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.80379441
20regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.77370217
21positive regulation of protein homodimerization activity (GO:0090073)3.76935337
22positive regulation of uterine smooth muscle contraction (GO:0070474)3.76763576
23positive regulation of heat generation (GO:0031652)3.71772830
24neuron cell-cell adhesion (GO:0007158)3.65089302
25negative regulation of mast cell activation (GO:0033004)3.52213432
26kidney morphogenesis (GO:0060993)3.51661608
27neuron-neuron synaptic transmission (GO:0007270)3.48764642
28negative chemotaxis (GO:0050919)3.46404034
29synaptic vesicle docking involved in exocytosis (GO:0016081)3.43446055
30regulation of heat generation (GO:0031650)3.37670070
31gamma-aminobutyric acid signaling pathway (GO:0007214)3.33011660
32regulation of synaptic transmission, GABAergic (GO:0032228)3.29003516
33cerebral cortex radially oriented cell migration (GO:0021799)3.26769267
34synaptic vesicle exocytosis (GO:0016079)3.20718274
35glutamate receptor signaling pathway (GO:0007215)3.17816910
36positive regulation of synapse maturation (GO:0090129)3.16208003
37opioid receptor signaling pathway (GO:0038003)3.13945436
38regulation of glutamate receptor signaling pathway (GO:1900449)3.12797249
39membrane assembly (GO:0071709)3.11925895
40positive regulation of synaptic transmission, GABAergic (GO:0032230)3.11265793
41regulation of activation of Janus kinase activity (GO:0010533)3.07194344
42regulation of synapse assembly (GO:0051963)3.07145548
43mechanosensory behavior (GO:0007638)3.04726913
44detection of molecule of bacterial origin (GO:0032490)3.01381941
45regulation of uterine smooth muscle contraction (GO:0070472)3.00937801
46negative regulation of exocytosis (GO:0045920)3.00666596
47mannosylation (GO:0097502)3.00034992
48regulation of fever generation (GO:0031620)2.97620563
49regulation of synaptic transmission, glutamatergic (GO:0051966)2.97201971
50facial nerve structural organization (GO:0021612)2.93828708
51response to histamine (GO:0034776)2.93332387
52protein localization to synapse (GO:0035418)2.92953723
53prostate gland growth (GO:0060736)2.90321803
54positive regulation of amino acid transport (GO:0051957)2.90248403
55regulation of chemokine-mediated signaling pathway (GO:0070099)2.88430856
56regulation of synaptic vesicle exocytosis (GO:2000300)2.86738976
57urinary tract smooth muscle contraction (GO:0014848)2.86192543
58aggressive behavior (GO:0002118)2.85701864
59protein localization to cilium (GO:0061512)2.85340953
60regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.84502504
61regulation of synaptic vesicle transport (GO:1902803)2.83686963
62behavioral response to nicotine (GO:0035095)2.83314184
63positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.82875148
64response to pheromone (GO:0019236)2.80792437
65response to auditory stimulus (GO:0010996)2.80164793
66superoxide anion generation (GO:0042554)2.80042859
67cerebellar granule cell differentiation (GO:0021707)2.79753283
68behavioral response to ethanol (GO:0048149)2.78488731
69positive regulation of action potential (GO:0045760)2.77719280
70neuron recognition (GO:0008038)2.75680334
71serotonin receptor signaling pathway (GO:0007210)2.72858710
72glutamate secretion (GO:0014047)2.72437695
73gamma-aminobutyric acid transport (GO:0015812)2.72310471
74cranial nerve structural organization (GO:0021604)2.71052176
75proline transport (GO:0015824)2.69815401
76sympathetic nervous system development (GO:0048485)2.69624138
77aminoglycoside antibiotic metabolic process (GO:0030647)2.68908557
78positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.68497634
79regulation of timing of cell differentiation (GO:0048505)2.64100517
80transferrin transport (GO:0033572)2.63185446
81membrane hyperpolarization (GO:0060081)2.62803357
82serotonin metabolic process (GO:0042428)2.61520556
83tachykinin receptor signaling pathway (GO:0007217)2.61289135
84regulation of amino acid transport (GO:0051955)2.61036555
85cAMP catabolic process (GO:0006198)2.60948802
86histone H3-K36 demethylation (GO:0070544)2.59816668
87ganglion development (GO:0061548)2.58411555
88negative regulation of dendrite development (GO:2000171)2.58178018
89cardiac ventricle formation (GO:0003211)2.58089372
90regulation of excitatory postsynaptic membrane potential (GO:0060079)2.57903115
91synaptic vesicle endocytosis (GO:0048488)2.52962612
92trivalent inorganic cation transport (GO:0072512)2.52004168
93ferric iron transport (GO:0015682)2.52004168
94cardiac chamber formation (GO:0003207)2.51310455
95negative regulation of stem cell proliferation (GO:2000647)2.50961148
96regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.50299639
97regulation of postsynaptic membrane potential (GO:0060078)2.47724914
98negative regulation of protein oligomerization (GO:0032460)2.46688789
99regulation of synapse organization (GO:0050807)2.44877579
100cyclic nucleotide catabolic process (GO:0009214)2.44677517

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human5.03582383
2EZH2_22144423_ChIP-Seq_EOC_Human3.82365438
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.43091352
4BP1_19119308_ChIP-ChIP_Hs578T_Human2.89157432
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.85279785
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.76911964
7TAF15_26573619_Chip-Seq_HEK293_Human2.68441463
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.50102680
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.45621279
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.41899086
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.39258947
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.35836523
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.29430005
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.25962116
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.24441103
16P300_19829295_ChIP-Seq_ESCs_Human2.23148953
17BMI1_23680149_ChIP-Seq_NPCS_Mouse2.19012946
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.13605926
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.12305676
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.10247678
21CBX2_27304074_Chip-Seq_ESCs_Mouse2.08067124
22POU3F2_20337985_ChIP-ChIP_501MEL_Human2.02049750
23FUS_26573619_Chip-Seq_HEK293_Human1.99709040
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.99565314
25EZH2_18974828_ChIP-Seq_MESCs_Mouse1.97559528
26RNF2_18974828_ChIP-Seq_MESCs_Mouse1.97559528
27PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.91906112
28SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.79796077
29VDR_22108803_ChIP-Seq_LS180_Human1.78407302
30SMAD4_21799915_ChIP-Seq_A2780_Human1.78076065
31PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.74390643
32EZH2_27294783_Chip-Seq_ESCs_Mouse1.72945938
33PIAS1_25552417_ChIP-Seq_VCAP_Human1.72487026
34REST_21632747_ChIP-Seq_MESCs_Mouse1.72315440
35RNF2_27304074_Chip-Seq_NSC_Mouse1.68601846
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.66885278
37RNF2_27304074_Chip-Seq_ESCs_Mouse1.66119881
38NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.64679475
39VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.62160580
40SUZ12_27294783_Chip-Seq_ESCs_Mouse1.61520903
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.60067986
42SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.55648072
43MTF2_20144788_ChIP-Seq_MESCs_Mouse1.55240361
44POU5F1_16153702_ChIP-ChIP_HESCs_Human1.53686388
45HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.53476451
46CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.50583045
47ER_23166858_ChIP-Seq_MCF-7_Human1.50096431
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.49210254
49CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49165775
50NANOG_18555785_Chip-Seq_ESCs_Mouse1.49003124
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48667313
52AR_25329375_ChIP-Seq_VCAP_Human1.44728188
53FLI1_27457419_Chip-Seq_LIVER_Mouse1.43070285
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41998116
55TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.41926149
56EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.38427012
57TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.36886974
58CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.36613693
59EWS_26573619_Chip-Seq_HEK293_Human1.35351709
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33879404
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32284589
62P53_22387025_ChIP-Seq_ESCs_Mouse1.31709521
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31522271
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31156974
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30439954
66POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30439954
67E2F1_18555785_Chip-Seq_ESCs_Mouse1.30364684
68ARNT_22903824_ChIP-Seq_MCF-7_Human1.29795311
69SUZ12_18555785_Chip-Seq_ESCs_Mouse1.28860334
70TP53_18474530_ChIP-ChIP_U2OS_Human1.28112950
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27154342
72AR_21572438_ChIP-Seq_LNCaP_Human1.26728818
73TAL1_26923725_Chip-Seq_HPCs_Mouse1.25692767
74STAT3_18555785_Chip-Seq_ESCs_Mouse1.23290712
75CMYC_18555785_Chip-Seq_ESCs_Mouse1.17683065
76EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.16848451
77BCAT_22108803_ChIP-Seq_LS180_Human1.16339603
78NFE2_27457419_Chip-Seq_LIVER_Mouse1.15623250
79TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15530112
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15186091
81NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14786194
82BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.14180138
83TCF4_23295773_ChIP-Seq_U87_Human1.13705765
84SOX2_18555785_Chip-Seq_ESCs_Mouse1.13633397
85AHR_22903824_ChIP-Seq_MCF-7_Human1.12894528
86STAT3_23295773_ChIP-Seq_U87_Human1.12788133
87TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12521710
88CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.10868215
89SOX9_26525672_Chip-Seq_HEART_Mouse1.09367650
90EZH2_27294783_Chip-Seq_NPCs_Mouse1.09202784
91CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08656186
92P300_18555785_Chip-Seq_ESCs_Mouse1.08103089
93RUNX2_22187159_ChIP-Seq_PCA_Human1.07298732
94KDM2B_26808549_Chip-Seq_REH_Human1.06281244
95PRDM14_20953172_ChIP-Seq_ESCs_Human1.05262042
96RUNX1_27457419_Chip-Seq_LIVER_Mouse1.04478828
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03096193
98REST_18959480_ChIP-ChIP_MESCs_Mouse1.02613613
99NMYC_18555785_Chip-Seq_ESCs_Mouse1.01749522
100LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01112234

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation4.30047448
2MP0003880_abnormal_central_pattern3.90086477
3MP0006292_abnormal_olfactory_placode3.80562547
4MP0000566_synostosis3.66086430
5MP0001188_hyperpigmentation3.52315764
6MP0005646_abnormal_pituitary_gland3.12415054
7MP0002735_abnormal_chemical_nociception2.84806317
8MP0002736_abnormal_nociception_after2.66182969
9MP0009745_abnormal_behavioral_response2.65263220
10MP0009046_muscle_twitch2.38327732
11MP0004859_abnormal_synaptic_plasticity2.37606550
12MP0009697_abnormal_copulation2.36026646
13MP0002638_abnormal_pupillary_reflex2.35549242
14MP0005645_abnormal_hypothalamus_physiol2.35310326
15MP0001968_abnormal_touch/_nociception2.21880374
16MP0003635_abnormal_synaptic_transmissio2.19622309
17MP0002064_seizures2.16349894
18MP0002572_abnormal_emotion/affect_behav2.13723224
19MP0010386_abnormal_urinary_bladder2.10877437
20MP0002876_abnormal_thyroid_physiology2.08718377
21MP0002277_abnormal_respiratory_mucosa2.06928320
22MP0002063_abnormal_learning/memory/cond1.95016544
23MP0001529_abnormal_vocalization1.91039428
24MP0002822_catalepsy1.88298436
25MP0002272_abnormal_nervous_system1.81531429
26MP0005248_abnormal_Harderian_gland1.78287616
27MP0001486_abnormal_startle_reflex1.66388582
28MP0006276_abnormal_autonomic_nervous1.64867771
29MP0001501_abnormal_sleep_pattern1.55747766
30MP0001346_abnormal_lacrimal_gland1.53976046
31MP0002557_abnormal_social/conspecific_i1.49629471
32MP0002067_abnormal_sensory_capabilities1.48989082
33MP0003787_abnormal_imprinting1.47627051
34MP0000778_abnormal_nervous_system1.47212749
35MP0004134_abnormal_chest_morphology1.46313873
36MP0008004_abnormal_stomach_pH1.45972526
37MP0001440_abnormal_grooming_behavior1.45740560
38MP0004742_abnormal_vestibular_system1.44910786
39MP0000678_abnormal_parathyroid_gland1.42835713
40MP0002751_abnormal_autonomic_nervous1.39884805
41MP0001502_abnormal_circadian_rhythm1.39526536
42MP0002184_abnormal_innervation1.35014340
43MP0000026_abnormal_inner_ear1.34018002
44MP0000049_abnormal_middle_ear1.33501843
45MP0005386_behavior/neurological_phenoty1.32541487
46MP0004924_abnormal_behavior1.32541487
47MP0001986_abnormal_taste_sensitivity1.30872253
48MP0001970_abnormal_pain_threshold1.30266530
49MP0002734_abnormal_mechanical_nocicepti1.28819135
50MP0003183_abnormal_peptide_metabolism1.28390131
51MP0005377_hearing/vestibular/ear_phenot1.27240566
52MP0003878_abnormal_ear_physiology1.27240566
53MP0008789_abnormal_olfactory_epithelium1.25837415
54MP0002254_reproductive_system_inflammat1.25819362
55MP0000681_abnormal_thyroid_gland1.20349695
56MP0002938_white_spotting1.20067266
57MP0005394_taste/olfaction_phenotype1.19743247
58MP0005499_abnormal_olfactory_system1.19743247
59MP0003879_abnormal_hair_cell1.19479437
60MP0003938_abnormal_ear_development1.18430670
61MP0001664_abnormal_digestion1.15738695
62MP0008260_abnormal_autophagy1.13797272
63MP0001177_atelectasis1.10921276
64MP0004147_increased_porphyrin_level1.08688585
65MP0001963_abnormal_hearing_physiology1.08121845
66MP0000631_abnormal_neuroendocrine_gland1.07132457
67MP0004133_heterotaxia1.05532350
68MP0004782_abnormal_surfactant_physiolog1.00140081
69MP0002132_abnormal_respiratory_system0.99589086
70MP0002733_abnormal_thermal_nociception0.94905724
71MP0008569_lethality_at_weaning0.94540904
72MP0008995_early_reproductive_senescence0.93140000
73MP0002069_abnormal_eating/drinking_beha0.93079930
74MP0001270_distended_abdomen0.92246852
75MP0001984_abnormal_olfaction0.90806742
76MP0003122_maternal_imprinting0.90276675
77MP0005367_renal/urinary_system_phenotyp0.87871029
78MP0000516_abnormal_urinary_system0.87871029
79MP0004811_abnormal_neuron_physiology0.85387214
80MP0002163_abnormal_gland_morphology0.82423987
81MP0005551_abnormal_eye_electrophysiolog0.81181011
82MP0002066_abnormal_motor_capabilities/c0.79889446
83MP0004885_abnormal_endolymph0.78744474
84MP0004043_abnormal_pH_regulation0.78040609
85MP0002882_abnormal_neuron_morphology0.77995567
86MP0009780_abnormal_chondrocyte_physiolo0.75186527
87MP0001485_abnormal_pinna_reflex0.73741857
88MP0002752_abnormal_somatic_nervous0.69354078
89MP0003303_peritoneal_inflammation0.68565781
90MP0006082_CNS_inflammation0.68512514
91MP0000372_irregular_coat_pigmentation0.66836626
92MP0000955_abnormal_spinal_cord0.66400322
93MP0003385_abnormal_body_wall0.66374533
94MP0005379_endocrine/exocrine_gland_phen0.64373397
95MP0004858_abnormal_nervous_system0.63518940
96MP0000538_abnormal_urinary_bladder0.62855576
97MP0003646_muscle_fatigue0.61697617
98MP0010030_abnormal_orbit_morphology0.61041294
99MP0003633_abnormal_nervous_system0.60545397
100MP0002332_abnormal_exercise_endurance0.58218130

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.93574466
2Hyperventilation (HP:0002883)4.70088254
3Epileptic encephalopathy (HP:0200134)3.91986831
4Abnormal hair whorl (HP:0010721)3.70040975
5Febrile seizures (HP:0002373)3.66869794
6Medial flaring of the eyebrow (HP:0010747)3.40796757
7Nephrogenic diabetes insipidus (HP:0009806)3.35544106
8Occipital encephalocele (HP:0002085)3.25187978
9Tented upper lip vermilion (HP:0010804)3.24668396
10Optic nerve hypoplasia (HP:0000609)3.12640596
11Retinal dysplasia (HP:0007973)3.08015765
12Gait imbalance (HP:0002141)3.02397810
13Hypothermia (HP:0002045)3.01829959
14Congenital primary aphakia (HP:0007707)2.96231384
15Thyroid-stimulating hormone excess (HP:0002925)2.91674814
16Renal dysplasia (HP:0000110)2.89208787
17Hypoplasia of the fovea (HP:0007750)2.85710270
18Aplasia/Hypoplasia of the fovea (HP:0008060)2.85710270
19Protruding tongue (HP:0010808)2.83203770
20Stomach cancer (HP:0012126)2.78566650
21Chromosomal breakage induced by crosslinking agents (HP:0003221)2.77204629
22Inability to walk (HP:0002540)2.72732326
23Chronic hepatic failure (HP:0100626)2.68203065
24Absent eyebrow (HP:0002223)2.66081210
25Absent speech (HP:0001344)2.65687243
26Congenital sensorineural hearing impairment (HP:0008527)2.62333545
27Retinal atrophy (HP:0001105)2.57281492
28Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.56220745
29Pancreatic fibrosis (HP:0100732)2.53684498
30Optic neuritis (HP:0100653)2.51333127
31Retrobulbar optic neuritis (HP:0100654)2.51333127
32Atonic seizures (HP:0010819)2.44571146
33Acute necrotizing encephalopathy (HP:0006965)2.43487721
34Type 2 muscle fiber atrophy (HP:0003554)2.38834884
35True hermaphroditism (HP:0010459)2.36463145
36Easy fatigability (HP:0003388)2.34511248
37Abnormal mitochondria in muscle tissue (HP:0008316)2.32377063
38Absent eyelashes (HP:0000561)2.28319410
39Septo-optic dysplasia (HP:0100842)2.28302269
40White forelock (HP:0002211)2.27846296
41Broad-based gait (HP:0002136)2.27648678
42Neoplasm of the adrenal cortex (HP:0100641)2.19769039
43Poor suck (HP:0002033)2.18828163
443-Methylglutaconic aciduria (HP:0003535)2.15610533
45Scanning speech (HP:0002168)2.15306126
46Preaxial hand polydactyly (HP:0001177)2.13872744
47Hepatoblastoma (HP:0002884)2.13476953
48Duplicated collecting system (HP:0000081)2.12962672
49Thickened helices (HP:0000391)2.12798893
50Vaginal atresia (HP:0000148)2.12401864
51Poor coordination (HP:0002370)2.12161369
52Abnormality of the fovea (HP:0000493)2.11969972
53Genital tract atresia (HP:0001827)2.11384799
54Abnormality of the renal collecting system (HP:0004742)2.09976548
55Blue irides (HP:0000635)2.09763777
56Patchy hypopigmentation of hair (HP:0011365)2.09039492
57Pancreatic cysts (HP:0001737)2.08815165
58Progressive macrocephaly (HP:0004481)2.06448845
59Chromsome breakage (HP:0040012)2.05799965
60Parakeratosis (HP:0001036)2.01295440
61Recurrent corneal erosions (HP:0000495)2.00926763
62Lissencephaly (HP:0001339)2.00634647
63Submucous cleft hard palate (HP:0000176)1.97814871
64Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.97721650
65Aplasia/Hypoplasia of the lens (HP:0008063)1.95363896
66Onycholysis (HP:0001806)1.92535832
67Intestinal atresia (HP:0011100)1.92079417
68Osteomalacia (HP:0002749)1.91602164
69Intellectual disability, moderate (HP:0002342)1.90277340
70Absent hair (HP:0002298)1.89771855
71Type II lissencephaly (HP:0007260)1.89322356
72Orchitis (HP:0100796)1.88669384
73Cerebellar dysplasia (HP:0007033)1.84756582
74Narrow nasal bridge (HP:0000446)1.83170600
75Bulbar palsy (HP:0001283)1.80200271
76Limb dystonia (HP:0002451)1.79870895
77Focal seizures (HP:0007359)1.79533918
78Dialeptic seizures (HP:0011146)1.79249047
79Gaze-evoked nystagmus (HP:0000640)1.78574823
80Abnormality of the labia minora (HP:0012880)1.78459967
81Bile duct proliferation (HP:0001408)1.78441219
82Abnormal biliary tract physiology (HP:0012439)1.78441219
83Anterior segment dysgenesis (HP:0007700)1.77058885
84Alveolar cell carcinoma (HP:0006519)1.73924541
85Acute encephalopathy (HP:0006846)1.73694471
86Meningocele (HP:0002435)1.73587120
87Abnormality of incisor morphology (HP:0011063)1.72969930
88Specific learning disability (HP:0001328)1.72786940
89Conical tooth (HP:0000698)1.71405734
90Aplasia/Hypoplasia of the tibia (HP:0005772)1.71191671
91Nephronophthisis (HP:0000090)1.69592884
92Conjugated hyperbilirubinemia (HP:0002908)1.67373431
93Astigmatism (HP:0000483)1.65722447
94Epileptiform EEG discharges (HP:0011182)1.63383752
95Hyperphosphatemia (HP:0002905)1.61983665
96Hypogonadotrophic hypogonadism (HP:0000044)1.61796427
97Fetal akinesia sequence (HP:0001989)1.61355670
98Drooling (HP:0002307)1.59607953
99Excessive salivation (HP:0003781)1.59607953
100Erectile abnormalities (HP:0100639)1.59544399

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK6.79515044
2AKT33.44981666
3MAP2K72.98292135
4PRPF4B2.85258219
5SIK32.70398902
6ZAK2.49845526
7NTRK32.34091066
8MUSK2.26775518
9SGK22.22479789
10TXK2.15966628
11TNIK1.97366164
12MARK11.71504760
13BMPR1B1.70219326
14YES11.64677309
15TSSK61.63731928
16NME11.60835495
17SGK4941.60005399
18SGK2231.60005399
19PLK21.59249507
20EPHA41.59219963
21CCNB11.56678818
22ADRBK21.54593613
23NTRK21.51391425
24NUAK11.51138161
25DAPK21.48128118
26MAP3K41.45482295
27BRAF1.42230347
28TIE11.38916571
29MAPK131.38470366
30CDK31.33916501
31STK38L1.29048514
32SGK31.27664974
33IRAK31.26478247
34CDK81.23527278
35MAP3K121.23267997
36EPHB21.20598475
37ERBB41.17966875
38PRKCE1.08345209
39GRK71.07901040
40KSR11.06296719
41BCR1.05650428
42PRKCG0.98081084
43FES0.92425020
44BMPR20.90465242
45MAP3K140.89383865
46ERBB30.84661388
47PLK40.82733909
48INSRR0.81780373
49MKNK20.80468998
50FGFR20.75791392
51WNK30.75201686
52SRPK10.73339866
53FRK0.72798379
54MAPK70.71175865
55LMTK20.68902395
56CAMK2A0.68885391
57EIF2AK20.67639984
58NEK60.67271168
59MAP3K70.66054616
60ADRBK10.64658834
61CDK190.62286662
62CSNK1A1L0.61225562
63PKN10.59182054
64TAOK20.59071727
65CAMK10.58429957
66OXSR10.57018264
67PRKG10.55903195
68MYLK0.55263307
69CAMK40.52789168
70CAMK2G0.52547529
71SGK10.50977771
72EPHA30.50747351
73MAPK120.49579189
74MINK10.48663427
75CSNK1G20.47601585
76CAMK2B0.47228808
77CSNK1G30.46956483
78PRKACA0.46832494
79TNK20.45273020
80DYRK20.44518272
81EIF2AK30.44046600
82MKNK10.40709615
83EPHA20.40223053
84DAPK10.39995113
85GRK50.39211061
86CDK50.38289727
87MAP2K40.37808510
88OBSCN0.37446189
89RPS6KB10.36689067
90PBK0.36415016
91IRAK40.36356977
92CAMK2D0.35443312
93FER0.35205370
94PINK10.34829590
95CHEK20.32885725
96DYRK1A0.32206168
97CSNK1A10.31087896
98ARAF0.28456040
99PRKCA0.27895861
100RIPK40.26645635

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.74958482
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004304.02710548
3Synaptic vesicle cycle_Homo sapiens_hsa047213.26891766
4Collecting duct acid secretion_Homo sapiens_hsa049663.14291911
5Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.65565646
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.56488775
7Rheumatoid arthritis_Homo sapiens_hsa053232.42971706
8Taste transduction_Homo sapiens_hsa047422.42553545
9Type I diabetes mellitus_Homo sapiens_hsa049402.35799525
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.35382529
11Morphine addiction_Homo sapiens_hsa050322.30913535
12Graft-versus-host disease_Homo sapiens_hsa053322.15010399
13GABAergic synapse_Homo sapiens_hsa047272.14419020
14Vibrio cholerae infection_Homo sapiens_hsa051101.87893708
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.81417177
16Circadian entrainment_Homo sapiens_hsa047131.76730200
17Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.75585415
18Serotonergic synapse_Homo sapiens_hsa047261.69851776
19Glutamatergic synapse_Homo sapiens_hsa047241.65773266
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56957034
21Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.50828809
22Allograft rejection_Homo sapiens_hsa053301.42934638
23Oxidative phosphorylation_Homo sapiens_hsa001901.37911732
24Sulfur metabolism_Homo sapiens_hsa009201.37370624
25Calcium signaling pathway_Homo sapiens_hsa040201.33867557
26Insulin secretion_Homo sapiens_hsa049111.30199668
27Phagosome_Homo sapiens_hsa041451.29922846
28Olfactory transduction_Homo sapiens_hsa047401.29254274
29SNARE interactions in vesicular transport_Homo sapiens_hsa041301.27612503
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.24880217
31Cyanoamino acid metabolism_Homo sapiens_hsa004601.24362066
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.19991750
33Arachidonic acid metabolism_Homo sapiens_hsa005901.17381405
34Axon guidance_Homo sapiens_hsa043601.11155089
35Long-term depression_Homo sapiens_hsa047301.09718495
36Vitamin digestion and absorption_Homo sapiens_hsa049771.00531747
37Cocaine addiction_Homo sapiens_hsa050300.97136847
38Amphetamine addiction_Homo sapiens_hsa050310.96098218
39Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91286212
40Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91025905
41Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.90680264
42Salivary secretion_Homo sapiens_hsa049700.90423723
43Intestinal immune network for IgA production_Homo sapiens_hsa046720.89503793
44Phototransduction_Homo sapiens_hsa047440.86594646
45* Autoimmune thyroid disease_Homo sapiens_hsa053200.85421669
46Hematopoietic cell lineage_Homo sapiens_hsa046400.83725651
47Renin secretion_Homo sapiens_hsa049240.82355932
48African trypanosomiasis_Homo sapiens_hsa051430.81049695
49NOD-like receptor signaling pathway_Homo sapiens_hsa046210.80193657
50Circadian rhythm_Homo sapiens_hsa047100.78040650
51Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.77384070
52Melanoma_Homo sapiens_hsa052180.77338085
53* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.75422905
54Dilated cardiomyopathy_Homo sapiens_hsa054140.74335984
55Protein export_Homo sapiens_hsa030600.73999103
56Fatty acid biosynthesis_Homo sapiens_hsa000610.67518536
57NF-kappa B signaling pathway_Homo sapiens_hsa040640.65878185
58Steroid hormone biosynthesis_Homo sapiens_hsa001400.64485101
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64406253
60Dopaminergic synapse_Homo sapiens_hsa047280.62962611
61Cholinergic synapse_Homo sapiens_hsa047250.61631711
62Legionellosis_Homo sapiens_hsa051340.60883593
63Alzheimers disease_Homo sapiens_hsa050100.58600341
64Butanoate metabolism_Homo sapiens_hsa006500.57084252
65* Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55406383
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53797799
67* Toll-like receptor signaling pathway_Homo sapiens_hsa046200.51959433
68Fatty acid elongation_Homo sapiens_hsa000620.51720969
69Asthma_Homo sapiens_hsa053100.50594138
70* Tuberculosis_Homo sapiens_hsa051520.49707886
71Parkinsons disease_Homo sapiens_hsa050120.48867827
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48474487
73cAMP signaling pathway_Homo sapiens_hsa040240.48306384
74Ovarian steroidogenesis_Homo sapiens_hsa049130.48272749
75Long-term potentiation_Homo sapiens_hsa047200.46953441
76Vitamin B6 metabolism_Homo sapiens_hsa007500.46036932
77Sphingolipid metabolism_Homo sapiens_hsa006000.45831617
78Huntingtons disease_Homo sapiens_hsa050160.41674194
79Ras signaling pathway_Homo sapiens_hsa040140.40430095
80Ether lipid metabolism_Homo sapiens_hsa005650.40221123
81MAPK signaling pathway_Homo sapiens_hsa040100.39802344
82Wnt signaling pathway_Homo sapiens_hsa043100.37922926
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.37189228
84Basal cell carcinoma_Homo sapiens_hsa052170.36734661
85Maturity onset diabetes of the young_Homo sapiens_hsa049500.36471131
86Oxytocin signaling pathway_Homo sapiens_hsa049210.36115855
87Malaria_Homo sapiens_hsa051440.35246308
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32587976
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.32571795
90Fanconi anemia pathway_Homo sapiens_hsa034600.31926097
91Gastric acid secretion_Homo sapiens_hsa049710.31527571
92Cardiac muscle contraction_Homo sapiens_hsa042600.30086387
93Endometrial cancer_Homo sapiens_hsa052130.29802677
94Basal transcription factors_Homo sapiens_hsa030220.29689546
95Mineral absorption_Homo sapiens_hsa049780.29034200
96Pertussis_Homo sapiens_hsa051330.28213829
97ABC transporters_Homo sapiens_hsa020100.26806307
98Prion diseases_Homo sapiens_hsa050200.24453771
99Linoleic acid metabolism_Homo sapiens_hsa005910.22711606
100Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.22258807

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